Lissencephaly
"Lissencephaly" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.
| Descriptor ID |
D054082
|
| MeSH Number(s) |
C10.500.507.450.499 C16.131.666.507.450.499
|
| Concept/Terms |
Pachygyria- Pachygyria
- Pachygyrias
- Broad Gyri of Cerebrum
- Large Gyri of Cerebrum
- Macrogyria
- Macrogyrias
|
Below are MeSH descriptors whose meaning is more general than "Lissencephaly".
Below are MeSH descriptors whose meaning is more specific than "Lissencephaly".
This graph shows the total number of publications written about "Lissencephaly" by people in this website by year, and whether "Lissencephaly" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lissencephaly" by people in Profiles.
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Hoff KJ, Aiken JE, Gutierrez MA, Franco SJ, Moore JK. TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics. Elife. 2022 05 05; 11.
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Aiken J, Moore JK, Bates EA. TUBA1A mutations identified in lissencephaly patients dominantly disrupt neuronal migration and impair dynein activity. Hum Mol Genet. 2019 04 15; 28(8):1227-1243.