 RNA, Spliced Leader
"RNA, Spliced Leader" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The small RNAs which provide spliced leader sequences, SL1, SL2, SL3, SL4 and SL5 (short sequences which are joined to the 5' ends of pre-mRNAs by TRANS-SPLICING). They are found primarily in primitive eukaryotes (protozoans and nematodes).
| Descriptor ID |
D020038
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| MeSH Number(s) |
D13.444.735.790.552.968
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| Concept/Terms |
Trans-Spliced Leader Sequences- Trans-Spliced Leader Sequences
- Leader Sequences, Trans-Spliced
- Sequences, Trans-Spliced Leader
- Trans Spliced Leader Sequences
- Spliced Leader Sequences
- Leader Sequences, Spliced
- Sequences, Spliced Leader
- Spliced Leader
- Leader, Spliced
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Below are MeSH descriptors whose meaning is more general than "RNA, Spliced Leader".
Below are MeSH descriptors whose meaning is more specific than "RNA, Spliced Leader".
This graph shows the total number of publications written about "RNA, Spliced Leader" by people in this website by year, and whether "RNA, Spliced Leader" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2010 | 2 | 2 | 4 | | 2011 | 1 | 2 | 3 |
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Below are the most recent publications written about "RNA, Spliced Leader" by people in Profiles.
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Liu W, Jankowska-Anyszka M, Piecyk K, Dickson L, Wallace A, Niedzwiecka A, Stepinski J, Stolarski R, Darzynkiewicz E, Kieft J, Zhao R, Jones DN, Davis RE. Structural basis for nematode eIF4E binding an m(2,2,7)G-Cap and its implications for translation initiation. Nucleic Acids Res. 2011 Nov 01; 39(20):8820-32.
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Lasda EL, Kuersten S, Blumenthal T. SL trans-splicing in a Caenorhabditis elegans in vitro extract. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5574.
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Lasda EL, Blumenthal T. Trans-splicing. Wiley Interdiscip Rev RNA. 2011 May-Jun; 2(3):417-34.
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Allen MA, Hillier LW, Waterston RH, Blumenthal T. A global analysis of C. elegans trans-splicing. Genome Res. 2011 Feb; 21(2):255-64.
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Morton JJ, Blumenthal T. Identification of transcription start sites of trans-spliced genes: uncovering unusual operon arrangements. RNA. 2011 Feb; 17(2):327-37.
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Lee JH, Cai G, Panigrahi AK, Dunham-Ems S, Nguyen TN, Radolf JD, Asturias FJ, G?nzl A. A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes. Mol Cell Biol. 2010 Dec; 30(23):5502-13.
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Lasda EL, Allen MA, Blumenthal T. Polycistronic pre-mRNA processing in vitro: snRNP and pre-mRNA role reversal in trans-splicing. Genes Dev. 2010 Aug 01; 24(15):1645-58.
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Cheng G, Cohen L, Mikhli C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE. In vivo translation and stability of trans-spliced mRNAs in nematode embryos. Mol Biochem Parasitol. 2007 Jun; 153(2):95-106.
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MacMorris M, Kumar M, Lasda E, Larsen A, Kraemer B, Blumenthal T. A novel family of C. elegans snRNPs contains proteins associated with trans-splicing. RNA. 2007 Apr; 13(4):511-20.
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Cheng G, Cohen L, Ndegwa D, Davis RE. The flatworm spliced leader 3'-terminal AUG as a translation initiator methionine. J Biol Chem. 2006 Jan 13; 281(2):733-43.
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