 PAX5 Transcription Factor
"PAX5 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A paired box transcription factor that is essential for CELL DIFFERENTIATION of B-LYMPHOCYTES. It functions both as a transcriptional activator and repressor to mediate B-cell commitment.
| Descriptor ID |
D051757
|
| MeSH Number(s) |
D12.776.260.645.500 D12.776.930.700.500
|
| Concept/Terms |
PAX5 Transcription Factor- PAX5 Transcription Factor
- Transcription Factor, PAX5
- B-Cell-Specific Activator Protein
- B Cell Specific Activator Protein
- Transcription Factor PAX5
- PAX5, Transcription Factor
- Paired Box 5 Protein
- B Cell-Specific Transcription Factor
- B Cell Specific Transcription Factor
- Early B Cell-Specific Binding Protein-1
- Early B Cell Specific Binding Protein 1
|
Below are MeSH descriptors whose meaning is more general than "PAX5 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "PAX5 Transcription Factor".
This graph shows the total number of publications written about "PAX5 Transcription Factor" by people in this website by year, and whether "PAX5 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 0 | 1 | 1 | | 2009 | 2 | 0 | 2 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "PAX5 Transcription Factor" by people in Profiles.
-
Somasundaram R, Jensen CT, Tingvall-Gustafsson J, ?hsberg J, Okuyama K, Prasad M, Hagman JR, Wang X, Soneji S, Strid T, Ungerb?ck J, Sigvardsson M. EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene. Blood. 2021 06 03; 137(22):3037-3049.
-
Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mr?zek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 02; 51(2):296-307.
-
Hart MR, Anderson DJ, Porter CC, Neff T, Levin M, Horwitz MS. Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations. PLoS Genet. 2018 09; 14(9):e1007642.
-
Fry TJ, Aplan PD. A robust in vivo model for B cell precursor acute lymphoblastic leukemia. J Clin Invest. 2015 Sep; 125(9):3427-9.
-
Prasad MA, Ungerb?ck J, ?hsberg J, Somasundaram R, Strid T, Larsson M, M?nsson R, De Paepe A, Lilljebj?rn H, Fioretos T, Hagman J, Sigvardsson M. Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency. Blood. 2015 Jun 25; 125(26):4052-9.
-
Liu GJ, Cimmino L, Jude JG, Hu Y, Witkowski MT, McKenzie MD, Kartal-Kaess M, Best SA, Tuohey L, Liao Y, Shi W, Mullighan CG, Farrar MA, Nutt SL, Smyth GK, Zuber J, Dickins RA. Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia. Genes Dev. 2014 Jun 15; 28(12):1337-50.
-
An N, Lin YW, Mahajan S, Kellner JN, Wang Y, Li Z, Kraft AS, Kang Y. Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells. Stem Cells. 2013 Jun; 31(6):1202-12.
-
Dege C, Hagman J. Activation of Aicda gene transcription by Pax5 in plasmacytoma cells. Immunol Res. 2013 Mar; 55(1-3):155-61.
-
Ram?rez J, Dege C, Kutateladze TG, Hagman J. MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexes. Mol Cell Biol. 2012 Dec; 32(24):5078-88.
-
Lukin K, Fields S, Guerrettaz L, Straign D, Rodriguez V, Zandi S, M?nsson R, Cambier JC, Sigvardsson M, Hagman J. A dose-dependent role for EBF1 in repressing non-B-cell-specific genes. Eur J Immunol. 2011 Jun; 41(6):1787-93.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|