 Multiple Endocrine Neoplasia Type 1
"Multiple Endocrine Neoplasia Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
| Descriptor ID |
D018761
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| MeSH Number(s) |
C04.588.322.400.500 C04.651.600.500 C04.700.630.500 C16.320.700.630.500 C19.344.400.500
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| Concept/Terms |
Multiple Endocrine Neoplasia Type 1- Multiple Endocrine Neoplasia Type 1
- Multiple Endocrine Neoplasia Type I
- Neoplasms, Multiple Endocrine Type I
- Multiple Endocrine Neoplasms Type 1
- Neoplasia, Multiple Endocrine Type 1
- Neoplasms, Multiple Endocrine Type 1
- Wermer Syndrome
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Below are MeSH descriptors whose meaning is more general than "Multiple Endocrine Neoplasia Type 1".
Below are MeSH descriptors whose meaning is more specific than "Multiple Endocrine Neoplasia Type 1".
This graph shows the total number of publications written about "Multiple Endocrine Neoplasia Type 1" by people in this website by year, and whether "Multiple Endocrine Neoplasia Type 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Multiple Endocrine Neoplasia Type 1" by people in Profiles.
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de Wilde RF, Heaphy CM, Maitra A, Meeker AK, Edil BH, Wolfgang CL, Ellison TA, Schulick RD, Molenaar IQ, Valk GD, Vriens MR, Borel Rinkes IH, Offerhaus GJ, Hruban RH, Matsukuma KE. Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. Mod Pathol. 2012 Jul; 25(7):1033-9.
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Shen HC, Rosen JE, Yang LM, Savage SA, Burns AL, Mateo CM, Agarwal SK, Chandrasekharappa SC, Spiegel AM, Collins FS, Marx SJ, Libutti SK. Parathyroid tumor development involves deregulation of homeobox genes. Endocr Relat Cancer. 2008 Mar; 15(1):267-75.
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