Lipoproteins, HDL
"Lipoproteins, HDL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.
| Descriptor ID |
D008075
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| MeSH Number(s) |
D10.532.432 D12.776.521.479
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| Concept/Terms |
Lipoproteins, HDL- Lipoproteins, HDL
- HDL Lipoproteins
- Heavy Lipoproteins
- Lipoproteins, Heavy
- High-Density Lipoproteins
- High Density Lipoproteins
- Lipoproteins, High-Density
- alpha-Lipoproteins
- alpha Lipoproteins
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Below are MeSH descriptors whose meaning is more general than "Lipoproteins, HDL".
Below are MeSH descriptors whose meaning is more specific than "Lipoproteins, HDL".
This graph shows the total number of publications written about "Lipoproteins, HDL" by people in this website by year, and whether "Lipoproteins, HDL" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2003 | 0 | 3 | 3 | | 2004 | 1 | 1 | 2 | | 2005 | 2 | 1 | 3 | | 2007 | 0 | 1 | 1 | | 2008 | 2 | 2 | 4 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 | | 2014 | 1 | 4 | 5 | | 2015 | 7 | 4 | 11 | | 2016 | 2 | 2 | 4 | | 2017 | 6 | 2 | 8 | | 2018 | 1 | 1 | 2 | | 2019 | 4 | 1 | 5 | | 2021 | 2 | 2 | 4 | | 2022 | 0 | 2 | 2 | | 2023 | 0 | 1 | 1 | | 2024 | 2 | 2 | 4 | | 2025 | 2 | 0 | 2 | | 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lipoproteins, HDL" by people in Profiles.
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Sun Z, Torphy RJ, Miller EN, Darehshouri A, Vigil I, Terai T, Eck E, Sun Y, Guo Y, Fykstra DP, Yee EJ, Hu J, Kedl RM, Lasda EL, Hesselberth JR, Siegenthaler JA, MacLean PS, Bruce KD, Randolph GJ, Schulick RD, Zhu Y. GPR182 is a lipoprotein receptor for dietary fat absorption. J Clin Invest. 2026 06 15; 136(12).
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Geh EN, Swertfeger DK, Roscoe I, Street SE, Bursey A, Sexmith H, Woollett LA, Davidson WS, Shah AS. Exchangeable APOA1 on HDL inhibits LDL binding to proteoglycans. J Lipid Res. 2025 Sep; 66(9):100885.
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Coleman B, Bedi S, Hill JH, Morris J, Manthei KA, Hart RC, He Y, Shah AS, Jerome WG, Vaisar T, Bornfeldt KE, Song H, Segrest JP, Heinecke JW, Aller SG, Tesmer JJG, Davidson WS. Lecithin:cholesterol acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL. J Lipid Res. 2025 05; 66(5):100786.
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Sarkar S, Morris J, You Y, Sexmith H, Street SE, Thibert SM, Attah IK, Hutchinson Bunch CM, Novikova IV, Evans JE, Shah AS, Gordon SM, Segrest JP, Bornfeldt KE, Vaisar T, Heinecke JW, Davidson WS, Melchior JT. APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1. J Lipid Res. 2024 12; 65(12):100686.
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Kothari V, Ho TWW, Cabodevilla AG, He Y, Kramer F, Shimizu-Albergine M, Kanter JE, Snell-Bergeon J, Fisher EA, Shao B, Heinecke JW, Wobbrock JO, Lee WL, Goldberg IJ, Vaisar T, Bornfeldt KE. Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis. Circ Res. 2024 Jul 05; 135(2):335-349.
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Gibson CM, Duffy D, Korjian S, Bahit MC, Chi G, Alexander JH, Lincoff AM, Heise M, Tricoci P, Deckelbaum LI, Mears SJ, Nicolau JC, Lopes RD, Merkely B, Lewis BS, Cornel JH, Trebacz J, Parkhomenko A, Libby P, Sacks FM, Povsic TJ, Bonaca M, Goodman SG, Bhatt DL, Tendera M, Steg PG, Ridker PM, Aylward P, Kastelein JJP, Bode C, Mahaffey KW, Nicholls SJ, Pocock SJ, Mehran R, Harrington RA. Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction. N Engl J Med. 2024 05 02; 390(17):1560-1571.
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Povsic TJ, Korjian S, Bahit MC, Chi G, Duffy D, Alexander JH, Vinereanu D, Tricoci P, Mears SJ, Deckelbaum LI, Bonaca M, Ridker PM, Goodman SG, Cornel JH, Lewis BS, Parkhomenko A, Lopes RD, Aylward P, Lincoff AM, Heise M, Sacks F, Nicolau JC, Merkely B, Trebacz J, Libby P, Nicholls SJ, Pocock S, Bhatt DL, Kastelein J, Bode C, Mahaffey KW, Steg PG, Tendera M, Bainey KR, Harrington RA, Mehran R, Duerschmied D, Kingwell BA, Gibson CM. Effect of Reconstituted Human Apolipoprotein A-I on Recurrent Ischemic Events in Survivors of Acute MI. J Am Coll Cardiol. 2024 Jun 04; 83(22):2163-2174.
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Merrill NJ, Davidson WS, He Y, Díaz Ludovico I, Sarkar S, Berger MR, McDermott JE, Van Eldik LJ, Wilcock DM, Monroe ME, Kyle JE, Bruce KD, Heinecke JW, Vaisar T, Raber J, Quinn JF, Melchior JT. Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health. Sci Adv. 2023 09; 9(35):eadi5571.
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Bonaca MP, Morrow DA, Bergmark BA, Berg DD, Lima JAC, Hoffmann U, Kato Y, Lu MT, Kuder J, Murphy SA, Spinar J, Oude Ophuis T, Kiss RG, Lopez-Sendon J, Averkov O, Wheatcroft SB, Kubica J, Carlos Nicolau J, Furtado RHM, Abuhatzira L, Hirshberg B, Omar SA, Vavere AL, Chang YT, George RT, Sabatine MS. Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment-Elevation Myocardial Infarction: Results of REAL-TIMI 63B. Circulation. 2022 09 20; 146(12):907-916.
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Bonaca MP, George RT, Morrow DA, Bergmark BA, Park JG, Abuhatzira L, Vavere AL, Karathanasis SK, Jin C, She D, Hirshberg B, Hsia J, Sabatine MS. Recombinant human lecithin-cholesterol acyltransferase in patients with atherosclerosis: phase 2a primary results and phase 2b design. Eur Heart J Cardiovasc Pharmacother. 2022 05 05; 8(3):243-252.
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