 Multiple Endocrine Neoplasia Type 2b
"Multiple Endocrine Neoplasia Type 2b" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
| Descriptor ID |
D018814
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| MeSH Number(s) |
C04.588.322.400.510 C04.651.600.510 C04.700.630.510 C16.320.700.630.510 C19.344.400.510
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| Concept/Terms |
Multiple Endocrine Neoplasia Type 2b- Multiple Endocrine Neoplasia Type 2b
- MEN2b
- Multiple Endocrine Neoplasms Type 2b
- Neoplasia, Multiple Endocrine Type 2b
- Neoplasms, Multiple Endocrine Type 2b
- Neuromata, Mucosal, With Endocrine Tumors
- Wagenmann-Froboese Syndrome
- Syndrome, Wagenmann-Froboese
- Wagenmann Froboese Syndrome
- Multiple Endocrine Neoplasia, Type IIb
- MEA 2b
- MEA IIb
- MEN 2b
- MEN 3
- MEN IIb
- MEN III
- Mucosal Neuroma Syndrome
- Mucosal Neuroma Syndromes
- Neuroma Syndrome, Mucosal
- Multiple Endocrine Neoplasia, Type 2b
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Below are MeSH descriptors whose meaning is more general than "Multiple Endocrine Neoplasia Type 2b".
Below are MeSH descriptors whose meaning is more specific than "Multiple Endocrine Neoplasia Type 2b".
This graph shows the total number of publications written about "Multiple Endocrine Neoplasia Type 2b" by people in this website by year, and whether "Multiple Endocrine Neoplasia Type 2b" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Multiple Endocrine Neoplasia Type 2b" by people in Profiles.
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Jellins T, Hill M, Prager JD, Francom CR, Chan CM, Schneider KW, Sharma A, Herrmann BW. Pediatric head and neck manifestations associated with multiple endocrine neoplasia syndromes. Int J Pediatr Otorhinolaryngol. 2023 Oct; 173:111703.
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Matthews MA, Adler BH, Arnold MA, Kumar S, Carvalho R, Besner GE. Diffuse intestinal ganglioneuromatosis in a child. J Pediatr Surg. 2013 May; 48(5):1129-33.
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Guinto ER, Closmann JJ. Dental rehabilitation of the patient with multiple endocrine neoplasia Type 2b. Gen Dent. 2007 Sep-Oct; 55(5):429-35.
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Jhiang SM, Fithian L, Weghorst CM, Clark OH, Falko JM, O'Dorisio TM, Mazzaferri EL. RET mutation screening in MEN2 patients and discovery of a novel mutation in a sporadic medullary thyroid carcinoma. Thyroid. 1996 Apr; 6(2):115-21.
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