 Ouabain
"Ouabain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.
| Descriptor ID |
D010042
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| MeSH Number(s) |
D04.210.500.155.580.130.750.600 D09.408.180.810.600
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| Concept/Terms |
Ouabain- Ouabain
- G-Strophanthin
- G Strophanthin
- Acocantherin
- Acolongifloroside K
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Below are MeSH descriptors whose meaning is more general than "Ouabain".
Below are MeSH descriptors whose meaning is more specific than "Ouabain".
This graph shows the total number of publications written about "Ouabain" by people in this website by year, and whether "Ouabain" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1998 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2016 | 0 | 2 | 2 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ouabain" by people in Profiles.
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Wu G, Li X, Seo H, McLendon BA, Kramer AC, Bazer FW, Johnson GA. Osteopontin (OPN)/Secreted Phosphoprotein 1 (SPP1) Binds Integrins to Activate Transport of Ions Across the Porcine Placenta. Front Biosci (Landmark Ed). 2022 04 01; 27(4):117.
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Yan Y, Shapiro AP, Mopidevi BR, Chaudhry MA, Maxwell K, Haller ST, Drummond CA, Kennedy DJ, Tian J, Malhotra D, Xie ZJ, Shapiro JI, Liu J. Protein Carbonylation of an Amino Acid Residue of the Na/K-ATPase a1 Subunit Determines Na/K-ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells. J Am Heart Assoc. 2016 09 09; 5(9).
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Ashbrook AW, Lentscher AJ, Zamora PF, Silva LA, May NA, Bauer JA, Morrison TE, Dermody TS. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. mBio. 2016 05 24; 7(3).
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Yan Y, Shapiro AP, Haller S, Katragadda V, Liu L, Tian J, Basrur V, Malhotra D, Xie ZJ, Abraham NG, Shapiro JI, Liu J. Involvement of reactive oxygen species in a feed-forward mechanism of Na/K-ATPase-mediated signaling transduction. J Biol Chem. 2013 Nov 22; 288(47):34249-34258.
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Song H, Thompson SM, Blaustein MP. Nanomolar ouabain augments Ca2+ signalling in rat hippocampal neurones and glia. J Physiol. 2013 Apr 01; 591(7):1671-89.
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Liu T, Brown DA, O'Rourke B. Role of mitochondrial dysfunction in cardiac glycoside toxicity. J Mol Cell Cardiol. 2010 Nov; 49(5):728-36.
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Dietz RM, Weiss JH, Shuttleworth CW. Zn2+ influx is critical for some forms of spreading depression in brain slices. J Neurosci. 2008 Aug 06; 28(32):8014-24.
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Dietz RM, Kiedrowski L, Shuttleworth CW. Contribution of Na(+)/Ca(2+) exchange to excessive Ca(2+) loading in dendrites and somata of CA1 neurons in acute slice. Hippocampus. 2007; 17(11):1049-59.
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Vad?sz I, Morty RE, Olschewski A, K?nigshoff M, Kohstall MG, Ghofrani HA, Grimminger F, Seeger W. Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):343-54.
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Johansson M, Jansson T, Powell TL. Na(+)-K(+)-ATPase is distributed to microvillous and basal membrane of the syncytiotrophoblast in human placenta. Am J Physiol Regul Integr Comp Physiol. 2000 Jul; 279(1):R287-94.
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