 alpha-Crystallin A Chain
"alpha-Crystallin A Chain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the subunits of alpha-crystallins. Unlike ALPHA-CRYSTALLIN B CHAIN the expression of ALPHA-CRYSTALLIN A CHAIN is limited primarily to the lens (LENS, CRYSTALLINE).
| Descriptor ID |
D038202
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| MeSH Number(s) |
D12.776.306.366.100.149 D12.776.580.157.149
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| Concept/Terms |
alpha-Crystallin A Chain- alpha-Crystallin A Chain
- alpha Crystallin A Chain
- alpha-Crystallin, A Subunit
- alpha Crystallin, A Subunit
- alpha A-Crystallin
- alpha A Crystallin
- Crystallins, alpha A Chain
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Below are MeSH descriptors whose meaning is more general than "alpha-Crystallin A Chain".
Below are MeSH descriptors whose meaning is more specific than "alpha-Crystallin A Chain".
This graph shows the total number of publications written about "alpha-Crystallin A Chain" by people in this website by year, and whether "alpha-Crystallin A Chain" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 | | 2008 | 2 | 0 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "alpha-Crystallin A Chain" by people in Profiles.
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Nandi SK, Nahomi RB, Rankenberg J, Glomb MA, Nagaraj RH. Glycation-mediated inter-protein cross-linking is promoted by chaperone-client complexes of a-crystallin: Implications for lens aging and presbyopia. J Biol Chem. 2020 04 24; 295(17):5701-5716.
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Mueller NH, Fogueri U, Pedler MG, Montana K, Petrash JM, Ammar DA. Impact of Subunit Composition on the Uptake of a-Crystallin by Lens and Retina. PLoS One. 2015; 10(9):e0137659.
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Sreekumar PG, Chothe P, Sharma KK, Baid R, Kompella U, Spee C, Kannan N, Manh C, Ryan SJ, Ganapathy V, Kannan R, Hinton DR. Antiapoptotic properties of a-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells. Invest Ophthalmol Vis Sci. 2013 Apr 17; 54(4):2787-98.
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Nahomi RB, Wang B, Raghavan CT, Voss O, Doseff AI, Santhoshkumar P, Nagaraj RH. Chaperone peptides of a-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts. J Biol Chem. 2013 May 03; 288(18):13022-35.
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Nahomi RB, Oya-Ito T, Nagaraj RH. The combined effect of acetylation and glycation on the chaperone and anti-apoptotic functions of human a-crystallin. Biochim Biophys Acta. 2013 Jan; 1832(1):195-203.
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Nagaraj RH, Nahomi RB, Shanthakumar S, Linetsky M, Padmanabha S, Pasupuleti N, Wang B, Santhoshkumar P, Panda AK, Biswas A. Acetylation of aA-crystallin in the human lens: effects on structure and chaperone function. Biochim Biophys Acta. 2012 Feb; 1822(2):120-9.
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Validandi V, Reddy VS, Srinivas PN, Mueller NH, Bhagyalaxmi SG, Padma T, Petrash JM, Reddy GB. Temperature-dependent structural and functional properties of a mutant (F71L) aA-crystallin: molecular basis for early onset of age-related cataract. FEBS Lett. 2011 Dec 15; 585(24):3884-9.
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Srinivas P, Narahari A, Petrash JM, Swamy MJ, Reddy GB. Importance of eye lens a-crystallin heteropolymer with 3:1 aA to aB ratio: stability, aggregation, and modifications. IUBMB Life. 2010 Sep; 62(9):693-702.
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Bhagyalaxmi SG, Srinivas P, Barton KA, Kumar KR, Vidyavathi M, Petrash JM, Bhanuprakash Reddy G, Padma T. A novel mutation (F71L) in alphaA-crystallin with defective chaperone-like function associated with age-related cataract. Biochim Biophys Acta. 2009 Oct; 1792(10):974-81.
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Kanade SR, Pasupuleti N, Nagaraj RH. Role of cysteine residues in the enhancement of chaperone function in methylglyoxal-modified human alpha A-crystallin. Mol Cell Biochem. 2009 Feb; 322(1-2):185-91.
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