 Colorectal Neoplasms, Hereditary Nonpolyposis
"Colorectal Neoplasms, Hereditary Nonpolyposis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
| Descriptor ID |
D003123
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| MeSH Number(s) |
C04.588.274.476.411.307.190 C04.700.250 C06.301.371.411.307.190 C06.405.249.411.307.190 C06.405.469.158.356.190 C06.405.469.491.307.190 C16.320.700.250 C18.452.284.255
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| Concept/Terms |
Hereditary Nonpolyposis Colorectal Cancer- Hereditary Nonpolyposis Colorectal Cancer
- Colorectal Cancer Hereditary Nonpolyposis
- Lynch Syndrome I
- Lynch Cancer Family Syndrome I
- Lynch Syndrome
- Syndrome, Lynch
- Colon Cancer, Familial Nonpolyposis
- Hereditary Nonpolyposis Colon Cancer
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Below are MeSH descriptors whose meaning is more general than "Colorectal Neoplasms, Hereditary Nonpolyposis".
- Diseases [C]
- Neoplasms [C04]
- Neoplasms by Site [C04.588]
- Digestive System Neoplasms [C04.588.274]
- Gastrointestinal Neoplasms [C04.588.274.476]
- Intestinal Neoplasms [C04.588.274.476.411]
- Colorectal Neoplasms [C04.588.274.476.411.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C04.588.274.476.411.307.190]
- Neoplastic Syndromes, Hereditary [C04.700]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C04.700.250]
- Digestive System Diseases [C06]
- Digestive System Neoplasms [C06.301]
- Gastrointestinal Neoplasms [C06.301.371]
- Intestinal Neoplasms [C06.301.371.411]
- Colorectal Neoplasms [C06.301.371.411.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.301.371.411.307.190]
- Gastrointestinal Diseases [C06.405]
- Gastrointestinal Neoplasms [C06.405.249]
- Intestinal Neoplasms [C06.405.249.411]
- Colorectal Neoplasms [C06.405.249.411.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.249.411.307.190]
- Intestinal Diseases [C06.405.469]
- Colonic Diseases [C06.405.469.158]
- Colorectal Neoplasms [C06.405.469.158.356]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.469.158.356.190]
- Intestinal Neoplasms [C06.405.469.491]
- Colorectal Neoplasms [C06.405.469.491.307]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.469.491.307.190]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
- Neoplastic Syndromes, Hereditary [C16.320.700]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C16.320.700.250]
- Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
- DNA Repair-Deficiency Disorders [C18.452.284]
- Colorectal Neoplasms, Hereditary Nonpolyposis [C18.452.284.255]
Below are MeSH descriptors whose meaning is more specific than "Colorectal Neoplasms, Hereditary Nonpolyposis".
This graph shows the total number of publications written about "Colorectal Neoplasms, Hereditary Nonpolyposis" by people in this website by year, and whether "Colorectal Neoplasms, Hereditary Nonpolyposis" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 2 | 0 | 2 | | 2018 | 3 | 1 | 4 | | 2020 | 1 | 0 | 1 | | 2021 | 5 | 0 | 5 | | 2022 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Colorectal Neoplasms, Hereditary Nonpolyposis" by people in Profiles.
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Schwartz ZP, Li AJ, Walsh CS, Rimel BJ, Alvarado MM, Lentz SE, Cass I. Patterns of care and outcomes of risk reducing surgery in women with pathogenic variants in non-BRCA and Lynch syndrome ovarian cancer susceptibility genes. Gynecol Oncol. 2023 06; 173:1-7.
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Colton MD, Tompkins K, O'Donnell E, Aisner D, Lieu CH, Konnick EQ, Fishbein L. Case of Metastatic Pheochromocytoma and Meningiomas in a Patient With Lynch Syndrome. JCO Precis Oncol. 2022 01; 6:e2100251.
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Leiman DA, Cardona DM, Kupfer SS, Rosenberg J, Bocsi GT, Hampel H. American Gastroenterological Association Institute and College of American Pathologists Quality Measure Development for Detection of Mismatch Repair Deficiency and Lynch Syndrome Management. Gastroenterology. 2022 02; 162(2):360-365.
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Karlitz JJ, Phillips A, Sorrells KS, Rao S. Genetic Analysis of Archived Tumor Specimens for Hereditary Colorectal Cancer Syndromes in the Cajuns of Louisiana, a US Founder Population. Clin Transl Gastroenterol. 2021 09 21; 12(9):e00392.
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Self C, Suttman A, Wolfe Schneider K, Hoffman L. Lynch syndrome: further defining the pediatric spectrum. Cancer Genet. 2021 11; 258-259:37-40.
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Mittendorf KF, Ukaegbu C, Gilmore MJ, Lindberg NM, Kauffman TL, Eubanks DJ, Shuster E, Allen J, McMullen C, Feigelson HS, Anderson KP, Leo MC, Hunter JE, Sasaki SO, Zepp JM, Syngal S, Wilfond BS, Goddard KAB. Adaptation and early implementation of the PREdiction model for gene mutations (PREMM5?) for lynch syndrome risk assessment in a diverse population. Fam Cancer. 2022 04; 21(2):167-180.
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Adviento B, Conner M, Sarkisian A, Walano N, Andersson H, Karlitz J. Feasibility of Utilizing PREMM Score for Lynch Syndrome Identification in an Urban, Minority Patient Population. J Prim Care Community Health. 2021 Jan-Dec; 12:21501327211020973.
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Mittal C, Dang D, Stoffel E, Menees S, Scott FI, Ahnen D, Patel SG. Underutilization of Lynch Syndrome Screening at Two Large Veterans Affairs Medical Centers. Dig Dis Sci. 2020 11; 65(11):3305-3315.
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Choi YH, Lakhal-Chaieb L, Kr?l A, Yu B, Buchanan D, Ahnen D, Le Marchand L, Newcomb PA, Win AK, Jenkins M, Lindor NM, Briollais L. Risks of Colorectal Cancer and Cancer-Related Mortality in Familial Colorectal Cancer Type X and Lynch Syndrome Families. J Natl Cancer Inst. 2019 07 01; 111(7):675-683.
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Pathak SJ, Mueller JL, Okamoto K, Das B, Hertecant J, Greenhalgh L, Cole T, Pinsk V, Yerushalmi B, Gurkan OE, Yourshaw M, Hernandez E, Oesterreicher S, Naik S, Sanderson IR, Axelsson I, Agardh D, Boland CR, Martin MG, Putnam CD, Sivagnanam M. EPCAM mutation update: Variants associated with congenital tufting enteropathy and Lynch syndrome. Hum Mutat. 2019 02; 40(2):142-161.
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