Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.
McKee AS, Munks MW, MacLeod MK, Fleenor CJ, Van Rooijen N, Kappler JW, Marrack P. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol. 2009 Oct 01; 183(7):4403-14.
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Adjuvants, Immunologic
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Alum Compounds
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Amino Acid Sequence
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Animals
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Biosensing Techniques
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Carrier Proteins
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Caspase 1
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Cell Movement
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Immunity, Cellular
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Immunity, Innate
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Inflammation Mediators
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Injections, Intraperitoneal
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Macrophages, Peritoneal
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Mast Cells
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Transgenic
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Molecular Sequence Data
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NLR Family, Pyrin Domain-Containing 3 Protein