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Joshua Cranston Black

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHARM General Operations

    Collapse Biography 
    Collapse education and training
    UCLA, Los Angeles CAPhD10/2008Molecular Biology
    MassachusettsGeneral Hospital, Bston MAPostdoctoral Fellow11/2015Cancer Epigenetics

    Collapse Research 
    Collapse research activities and funding
    R01AI155918     (BLACK, JOSHUA CRANSTON)Jan 4, 2021 - Dec 31, 2024
    NIH
    Defining the Role of DNA Rereplication of Chromosome 21 in the Development and Pathophysiology of Down Syndrome
    Role: Principal Investigator
    R35GM128720     (BLACK, JOSHUA CRANSTON)Aug 1, 2018 - Jul 31, 2023
    NIH
    Understanding Epigenetic Regulation of Copy Number Heterogeneity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Menzel J, Tatman P, Black JC. Isolation and analysis of rereplicated DNA by Rerep-Seq. Nucleic Acids Res. 2020 06 04; 48(10):e58. PMID: 32239215.
      View in: PubMed
    2. Menzel J, Black JC. Epigenetic Modulation of the Tumor Immune Microenvironment to Potentiate Immune Checkpoint Blockade Therapy. Cancer Discov. 2020 02; 10(2):179-181. PMID: 32024681.
      View in: PubMed
    3. Zhang Y, Bertulat B, Tencer AH, Ren X, Wright GM, Black J, Cardoso MC, Kutateladze TG. MORC3 Forms Nuclear Condensates through Phase Separation. iScience. 2019 Jul 26; 17:182-189. PMID: 31284181.
      View in: PubMed
    4. Zhang Y, Ahn J, Green KJ, Vann KR, Black J, Brooke CB, Kutateladze TG. MORC3 Is a Target of the Influenza A Viral Protein NS1. Structure. 2019 06 04; 27(6):1029-1033.e3. PMID: 31006586.
      View in: PubMed
    5. Zhang Y, Klein BJ, Cox KL, Bertulat B, Tencer AH, Holden MR, Wright GM, Black J, Cardoso MC, Poirier MG, Kutateladze TG. Mechanism for autoinhibition and activation of the MORC3 ATPase. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6111-6119. PMID: 30850548.
      View in: PubMed
    6. Mishra S, Van Rechem C, Pal S, Clarke TL, Chakraborty D, Mahan SD, Black JC, Murphy SE, Lawrence MS, Daniels DL, Whetstine JR. Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell. 2018 Nov 29; 175(6):1716. PMID: 30500540.
      View in: PubMed
    7. Wang M, Han J, Marcar L, Black J, Liu Q, Li X, Nagulapalli K, Sequist LV, Mak RH, Benes CH, Hong TS, Gurtner K, Krause M, Baumann M, Kang JX, Whetstine JR, Willers H. Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway. Cancer Res. 2017 04 15; 77(8):2018-2028. PMID: 28202526.
      View in: PubMed
    8. Black JC, Zhang H, Kim J, Getz G, Whetstine JR. Regulation of Transient Site-specific Copy Gain by MicroRNA. J Biol Chem. 2016 Mar 04; 291(10):4862-71. PMID: 26755726.
      View in: PubMed
    9. Black JC, Whetstine JR. RNF2 E3 or Not to E3: Dual Roles of RNF2 Overexpression in Melanoma. Cancer Discov. 2015 Dec; 5(12):1241-3. PMID: 26637658.
      View in: PubMed
    10. Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ram?rez CM, Li Y, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, Vrbanac V, Lu YC, Hla T, de Cabo R, Tsang JS, Schadt E, Sabeti PC, Kathiresan S, Cohen DE, Whetstine J, Chung RT, Fern?ndez-Hernando C, Kaplan LM, Bernards A, Gerszten RE, N??r AM. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. Nat Med. 2015 Nov; 21(11):1290-7. PMID: 26501192.
      View in: PubMed
    11. Tajima K, Yae T, Javaid S, Tam O, Comaills V, Morris R, Wittner BS, Liu M, Engstrom A, Takahashi F, Black JC, Ramaswamy S, Shioda T, Hammell M, Haber DA, Whetstine JR, Maheswaran S. SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes. Nat Commun. 2015 Sep 23; 6:8257. PMID: 26394836.
      View in: PubMed
    12. Black JC, Whetstine JR. Too little O2 Too much gain. Cell Cycle. 2015; 14(18):2869-70. PMID: 26221746.
      View in: PubMed
    13. Black JC, Atabakhsh E, Kim J, Biette KM, Van Rechem C, Ladd B, Burrowes PD, Donado C, Mattoo H, Kleinstiver BP, Song B, Andriani G, Joung JK, Iliopoulos O, Montagna C, Pillai S, Getz G, Whetstine JR. Hypoxia drives transient site-specific copy gain and drug-resistant gene expression. Genes Dev. 2015 May 15; 29(10):1018-31. PMID: 25995187.
      View in: PubMed
    14. Van Rechem C, Black JC, Greninger P, Zhao Y, Donado C, Burrowes PD, Ladd B, Christiani DC, Benes CH, Whetstine JR. A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR inhibitors. Cancer Discov. 2015 Mar; 5(3):245-54. PMID: 25564517.
      View in: PubMed
    15. Van Rechem C, Black JC, Boukhali M, Aryee MJ, Gr?slund S, Haas W, Benes CH, Whetstine JR. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015 Mar; 5(3):255-63. PMID: 25564516.
      View in: PubMed
    16. Javaid S, Zhang J, Anderssen E, Black JC, Wittner BS, Tajima K, Ting DT, Smolen GA, Zubrowski M, Desai R, Maheswaran S, Ramaswamy S, Whetstine JR, Haber DA. Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1. Cell Rep. 2013 Dec 26; 5(6):1679-89. PMID: 24360956.
      View in: PubMed
    17. Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, N??r AM. Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR. Sci Transl Med. 2013 Nov 20; 5(212):212ra162. PMID: 24259050.
      View in: PubMed
    18. Black JC, Manning AL, Van Rechem C, Kim J, Ladd B, Cho J, Pineda CM, Murphy N, Daniels DL, Montagna C, Lewis PW, Glass K, Allis CD, Dyson NJ, Getz G, Whetstine JR. KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell. 2013 Aug 01; 154(3):541-55. PMID: 23871696.
      View in: PubMed
    19. Black JC, Whetstine JR. Tipping the lysine methylation balance in disease. Biopolymers. 2013 Feb; 99(2):127-35. PMID: 23175387.
      View in: PubMed
    20. Black JC, Van Rechem C, Whetstine JR. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol Cell. 2012 Nov 30; 48(4):491-507. PMID: 23200123.
      View in: PubMed
    21. Black JC, Whetstine JR. LOX out, histones: a new enzyme is nipping at your tails. Mol Cell. 2012 May 11; 46(3):243-4. PMID: 22578539.
      View in: PubMed
    22. Van Rechem C, Black JC, Abbas T, Allen A, Rinehart CA, Yuan GC, Dutta A, Whetstine JR. The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. J Biol Chem. 2011 Sep 02; 286(35):30462-30470. PMID: 21757720.
      View in: PubMed
    23. Black JC, Whetstine JR. Chromatin landscape: methylation beyond transcription. Epigenetics. 2011 Jan; 6(1):9-15. PMID: 20855937.
      View in: PubMed
    24. Black JC, Allen A, Van Rechem C, Forbes E, Longworth M, Tsch?p K, Rinehart C, Quiton J, Walsh R, Smallwood A, Dyson NJ, Whetstine JR. Conserved antagonism between JMJD2A/KDM4A and HP1? during cell cycle progression. Mol Cell. 2010 Dec 10; 40(5):736-48. PMID: 21145482.
      View in: PubMed
    25. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, N??r AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 01; 24(13):1403-17. PMID: 20595232.
      View in: PubMed
    26. Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale ST. A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 2009 Jul 10; 138(1):114-28. PMID: 19596239.
      View in: PubMed
    27. Black JC, Mosley A, Kitada T, Washburn M, Carey M. The SIRT2 deacetylase regulates autoacetylation of p300. Mol Cell. 2008 Nov 07; 32(3):449-55. PMID: 18995842.
      View in: PubMed
    28. Smallwood A, Black JC, Tanese N, Pradhan S, Carey M. HP1-mediated silencing targets Pol II coactivator complexes. Nat Struct Mol Biol. 2008 Mar; 15(3):318-20. PMID: 18264112.
      View in: PubMed
    29. Black JC, Choi JE, Lombardo SR, Carey M. A mechanism for coordinating chromatin modification and preinitiation complex assembly. Mol Cell. 2006 Sep 15; 23(6):809-18. PMID: 16973433.
      View in: PubMed
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