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Anthony Joseph Saviola

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD. Altered metabolism and DAM-signatures in female brains and microglia with aging. Brain Res. 2024 Apr 15; 1829:148772. PMID: 38244754.
      View in: PubMed
    2. Chalivendra S, Shi S, Li X, Kuang Z, Giovinazzo J, Zhang L, Rossi J, Saviola AJ, Wang J, Welty R, Liu S, Vaeth K, Zhou ZH, Hansen KC, Taliaferro JM, Zhao R. Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast. bioRxiv. 2023 Dec 15. PMID: 38168357.
      View in: PubMed
    3. Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD. Altered Metabolism and DAM-signatures in Female Brains and Microglia with Aging. bioRxiv. 2023 Nov 30. PMID: 38076915.
      View in: PubMed
    4. Stincone P, Naimi A, Saviola AJ, Reher R, Petras D. Decoding the molecular interplay in the central dogma: An overview of mass spectrometry-based methods to investigate protein-metabolite interactions. Proteomics. 2023 Nov 06; e2200533. PMID: 37929699.
      View in: PubMed
    5. McCabe MC, Okamura DM, Erickson CB, Perry BW, Brewer CM, Nguyen ED, Saviola AJ, Majesky MW, Hansen KC. ECM-Focused Proteomic Analysis of Ear Punch Regeneration in Acomys Cahirinus. bioRxiv. 2023 Oct 17. PMID: 37873317.
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    6. Bowers SLK, Meng Q, Kuwabara Y, Huo J, Minerath R, York AJ, Sargent MA, Prasad V, Saviola AJ, Galindo DC, Hansen KC, Vagnozzi RJ, Yutzey KE, Molkentin JD. Col1a2-Deleted Mice Have Defective Type I Collagen and Secondary Reactive Cardiac Fibrosis with Altered Hypertrophic Dynamics. Cells. 2023 08 30; 12(17). PMID: 37681905.
      View in: PubMed
    7. McCabe MC, Gejji V, Barnebey A, Siuzdak G, Hoang LT, Pham T, Larson KY, Saviola AJ, Yannone SM, Hansen KC. From volcanoes to the bench: Advantages of novel hyperthermoacidic archaeal proteases for proteomics workflows. J Proteomics. 2023 10 30; 289:104992. PMID: 37634627.
      View in: PubMed
    8. Gadwa J, Amann M, Bickett TE, Knitz MW, Darragh LB, Piper M, Van Court B, Bukkapatnam S, Pham TT, Wang XJ, Saviola AJ, Deak LC, Uma?a P, Klein C, D'Alessandro A, Karam SD. Selective targeting of IL2R?? combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC. Cell Rep Med. 2023 08 15; 4(8):101150. PMID: 37586327.
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    9. Duran P, Boscolo Sesillo F, Cook M, Burnett L, Menefee SA, Do E, French S, Zazueta-Damian G, Dzieciatkowska M, Saviola AJ, Shah MM, Sanvictores C, Osborn KG, Hansen KC, Shtrahman M, Christman KL, Alperin M. Proregenerative extracellular matrix hydrogel mitigates pathological alterations of pelvic skeletal muscles after birth injury. Sci Transl Med. 2023 08 02; 15(707):eabj3138. PMID: 37531414.
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    10. Plewes MR, Talbott HA, Saviola AJ, Woods NT, Schott MB, Davis JS. Luteal Lipid Droplets: A Novel Platform for Steroid Synthesis. Endocrinology. 2023 08 01; 164(9). PMID: 37586092.
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    11. Yates J, Gomes F, Durbin K, Schauer K, Nwachukwu J, Russo R, Njeri J, Saviola A, McClatchy D, Diedrich J, Garrett P, Papa A, Ciolacu I, Kelleher N, Nettles K. Native top-down proteomics reveals EGFR-ERa signaling crosstalk in breast cancer cells dissociates NUTF2 dimers to modulate ERa signaling and cell growth. Res Sq. 2023 Jul 24. PMID: 37546719.
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    12. Smith CF, Nikolakis ZL, Perry BW, Schield DR, Meik JM, Saviola AJ, Castoe TA, Parker J, Mackessy SP. The best of both worlds? Rattlesnake hybrid zones generate complex combinations of divergent venom phenotypes that retain high toxicity. Biochimie. 2023 Oct; 213:176-189. PMID: 37451532.
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    13. Smith CF, Nikolakis ZL, Ivey K, Perry BW, Schield DR, Balchan NR, Parker J, Hansen KC, Saviola AJ, Castoe TA, Mackessy SP. Snakes on a plain: biotic and abiotic factors determine venom compositional variation in a wide-ranging generalist rattlesnake. BMC Biol. 2023 06 06; 21(1):136. PMID: 37280596.
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    14. Westfall AK, Gopalan SS, Perry BW, Adams RH, Saviola AJ, Mackessy SP, Castoe TA. Single-Cell Heterogeneity in Snake Venom Expression Is Hardwired by Co-Option of Regulators from Progressively Activated Pathways. Genome Biol Evol. 2023 Jun 01; 15(6). PMID: 37311204.
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    15. Calvete JJ, Lomonte B, Saviola AJ, Calder?n Celis F, Ruiz Encinar J. Quantification of snake venom proteomes by mass spectrometry-considerations and perspectives. Mass Spectrom Rev. 2023 May 08. PMID: 37155340.
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    16. Piper M, Hoen M, Darragh LB, Knitz MW, Nguyen D, Gadwa J, Durini G, Karakoc I, Grier A, Neupert B, Van Court B, Abdelazeem KNM, Yu J, Olimpo NA, Corbo S, Ross RB, Pham TT, Joshi M, Kedl RM, Saviola AJ, Amann M, Uma?a P, Codarri Deak L, Klein C, D'Alessandro A, Karam SD. Simultaneous targeting of PD-1 and IL-2R?? with radiation therapy inhibits pancreatic cancer growth and metastasis. Cancer Cell. 2023 05 08; 41(5):950-969.e6. PMID: 37116489.
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    17. Bubak AN, Coughlan C, Posey J, Saviola AJ, Niemeyer CS, Lewis SWR, Lopez SB, Solano A, Tyring SK, Delaney C, Neeves KB, Mahalingam R, Hansen KC, Nagel MA. Zoster-Associated Prothrombotic Plasma Exosomes and Increased Stroke Risk. J Infect Dis. 2023 04 18; 227(8):993-1001. PMID: 36200236.
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    18. Lee E, Redzic JS, Saviola AJ, Li X, Ebmeier CC, Kutateladze T, Hansen KC, Zhao R, Ahn N, Sluchanko NN, Eisenmesser E. Molecular insight into the specific interactions of the SARS-Coronavirus-2 nucleocapsid with RNA and host protein. Protein Sci. 2023 04; 32(4):e4603. PMID: 36807437.
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    19. McCabe MC, Saviola AJ, Hansen KC. Mass Spectrometry-Based Atlas of Extracellular Matrix Proteins across 25 Mouse Organs. J Proteome Res. 2023 03 03; 22(3):790-801. PMID: 36763087.
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    20. Grabowsky ER, Saviola AJ, Alvarado-D?az J, Mascare?as AQ, Hansen KC, Yates JR, Mackessy SP. Montane Rattlesnakes in M?xico: Venoms of Crotalus tancitarensis and Related Species within the Crotalus intermedius Group. Toxins (Basel). 2023 01 13; 15(1). PMID: 36668891.
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    21. Lee E, Redzic JS, Nemkov T, Saviola AJ, Dzieciatkowska M, Hansen KC, D'Alessandro A, Dinarello C, Eisenmesser EZ. Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions. Molecules. 2022 Jul 14; 27(14). PMID: 35889366.
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    22. Hunter JD, Hancko A, Shakya P, Hill R, Saviola AJ, Hansen KC, Davis ME, Christman KL. Characterization of decellularized left and right ventricular myocardial matrix hydrogels and their effects on cardiac progenitor cells. J Mol Cell Cardiol. 2022 Oct; 171:45-55. PMID: 35780862.
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    23. Modahl CM, Saviola AJ, Mackessy SP. Integration of transcriptomic and proteomic approaches for snake venom profiling. Expert Rev Proteomics. 2021 10; 18(10):827-834. PMID: 34663159.
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    24. Kalita B, Saviola AJ, Samuel SP, Mukherjee AK. State-of-the-art review - A review on snake venom-derived antithrombotics: Potential therapeutics for COVID-19-associated thrombosis? Int J Biol Macromol. 2021 Dec 01; 192:1040-1057. PMID: 34656540.
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    25. Das B, Saviola AJ, Mukherjee AK. Biochemical and Proteomic Characterization, and Pharmacological Insights of Indian Red Scorpion Venom Toxins. Front Pharmacol. 2021; 12:710680. PMID: 34650430.
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    26. Robinson KE, Holding ML, Whitford MD, Saviola AJ, Yates JR, Clark RW. Phenotypic and functional variation in venom and venom resistance of two sympatric rattlesnakes and their prey. J Evol Biol. 2021 09; 34(9):1447-1465. PMID: 34322920.
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    27. Calvete JJ, Lomonte B, Saviola AJ, Bonilla F, Sasa M, Williams DJ, Undheim EAB, Sunagar K, Jackson TNW. Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance. Toxicon X. 2021 Jul; 9-10:100070. PMID: 34195606.
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    28. Kalita B, Saviola AJ, Mukherjee AK. From venom to drugs: a review and critical analysis of Indian snake venom toxins envisaged as anticancer drug prototypes. Drug Discov Today. 2021 04; 26(4):993-1005. PMID: 33486112.
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    29. Fern?ndez-Costa C, Mart?nez-Bartolom? S, McClatchy DB, Saviola AJ, Yu NK, Yates JR. Impact of the Identification Strategy on the Reproducibility of the DDA and DIA Results. J Proteome Res. 2020 08 07; 19(8):3153-3161. PMID: 32510229.
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    30. Saviola AJ, Negr?o F, Yates JR. Proteomics of Select Neglected Tropical Diseases. Annu Rev Anal Chem (Palo Alto Calif). 2020 06 12; 13(1):315-336. PMID: 32109150.
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    31. Gomes FP, Diedrich JK, Saviola AJ, Memili E, Moura AA, Yates JR. EThcD and 213 nm UVPD for Top-Down Analysis of Bovine Seminal Plasma Proteoforms on Electrophoretic and Chromatographic Time Frames. Anal Chem. 2020 02 18; 92(4):2979-2987. PMID: 31962043.
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    32. Ul-Hasan S, Rodr?guez-Rom?n E, Reitzel AM, Adams RMM, Herzig V, Nobile CJ, Saviola AJ, Trim SA, Stiers EE, Moschos SA, Keiser CN, Petras D, Moran Y, Colston TJ. The emerging field of venom-microbiomics for exploring venom as a microenvironment, and the corresponding Initiative for Venom Associated Microbes and Parasites (iVAMP). Toxicon X. 2019 Oct; 4:100016. PMID: 32550573.
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    33. Saviola AJ, Zimmermann C, Mariani MP, Signorelli SA, Gerrard DL, Boyd JR, Wight DJ, Morissette G, Gravel A, Dubuc I, Flamand L, Kaufer BB, Frietze S. Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A. Front Microbiol. 2019; 10:1408. PMID: 31293546.
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    34. Jones BK, Saviola AJ, Reilly SB, Stubbs AL, Arida E, Iskandar DT, McGuire JA, Yates JR, Mackessy SP. Venom Composition in a Phenotypically Variable Pit Viper ( Trimeresurus insularis) across the Lesser Sunda Archipelago. J Proteome Res. 2019 05 03; 18(5):2206-2220. PMID: 30958009.
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    35. Mackessy SP, Leroy J, Moci?o-Deloya E, Setser K, Bryson RW, Saviola AJ. Venom Ontogeny in the Mexican Lance-Headed Rattlesnake (Crotalus polystictus). Toxins (Basel). 2018 07 03; 10(7). PMID: 29970805.
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    36. Mukherjee AK, Saviola AJ, Mackessy SP. Cellular mechanism of resistance of human colorectal adenocarcinoma cells against apoptosis-induction by Russell's Viper venom l-amino acid oxidase (Rusvinoxidase). Biochimie. 2018 Jul; 150:8-15. PMID: 29702182.
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    37. Pla D, Petras D, Saviola AJ, Modahl CM, Sanz L, P?rez A, Ju?rez E, Frietze S, Dorrestein PC, Mackessy SP, Calvete JJ. Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam. J Proteomics. 2018 03 01; 174:71-84. PMID: 29292096.
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    38. Saviola AJ, Gandara AJ, Bryson RW, Mackessy SP. Venom phenotypes of the Rock Rattlesnake (Crotalus lepidus) and the Ridge-nosed Rattlesnake (Crotalus willardi) from M?xico and the United States. Toxicon. 2017 Nov; 138:119-129. PMID: 28827138.
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    39. Mackessy SP, Saviola AJ. Understanding Biological Roles of Venoms Among the Caenophidia: The Importance of Rear-Fanged Snakes. Integr Comp Biol. 2016 11; 56(5):1004-1021. PMID: 27639275.
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    40. Ramos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G, Sboner A, Zhang T, Xiang J, Merghoub T, Levin LR, Buck J, Zippin JH. The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein. Oncotarget. 2016 Jul 19; 7(29):45597-45607. PMID: 27323809.
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    41. Saviola AJ, Burns PD, Mukherjee AK, Mackessy SP. The disintegrin tzabcanin inhibits adhesion and migration in melanoma and lung cancer cells. Int J Biol Macromol. 2016 Jul; 88:457-64. PMID: 27060015.
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    42. Mukherjee AK, Saviola AJ, Burns PD, Mackessy SP. Apoptosis induction in human breast cancer (MCF-7) cells by a novel venom L-amino acid oxidase (Rusvinoxidase) is independent of its enzymatic activity and is accompanied by caspase-7 activation and reactive oxygen species production. Apoptosis. 2015 Oct; 20(10):1358-72. PMID: 26319994.
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    43. Saviola AJ, Modahl CM, Mackessy SP. Disintegrins of Crotalus simus tzabcan venom: Isolation, characterization and evaluation of the cytotoxic and anti-adhesion activities of tzabcanin, a new RGD disintegrin. Biochimie. 2015 Sep; 116:92-102. PMID: 26163300.
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    44. Saviola AJ, Pla D, Sanz L, Castoe TA, Calvete JJ, Mackessy SP. Comparative venomics of the Prairie Rattlesnake (Crotalus viridis viridis) from Colorado: Identification of a novel pattern of ontogenetic changes in venom composition and assessment of the immunoreactivity of the commercial antivenom CroFab?. J Proteomics. 2015 May 21; 121:28-43. PMID: 25819372.
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    45. Bradshaw MJ, Saviola AJ, Fesler E, Mackessy SP. Evaluation of cytotoxic activities of snake venoms toward breast (MCF-7) and skin cancer (A-375) cell lines. Cytotechnology. 2016 Aug; 68(4):687-700. PMID: 25407733.
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    46. Saviola AJ, Chiszar D, Busch C, Mackessy SP. Molecular basis for prey relocation in viperid snakes. BMC Biol. 2013 Mar 01; 11:20. PMID: 23452837.
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