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Gregory P. Downey

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/398-1436

    Collapse Research 
    Collapse research activities and funding
    K08HL002039     (DOWNEY, GREGORY PAUL)Jul 1, 1987 - Jun 30, 1988
    NIH/NHLBI
    PROSTAGLANDINS AND NEUTROPHIL-MEDIATED LUNG INJURY
    Role: Principal Investigator

    R01HL090669     (DOWNEY, GREGORY PAUL)Jul 8, 2008 - Jun 30, 2013
    NIH/NHLBI
    Focal Adhesion Modulation of IL-1 Signaling: Importance in Pulmonary Fibrosis
    Role: Principal Investigator

    R21ES023932     (DOWNEY, GREGORY PAUL)May 5, 2014 - Apr 30, 2016
    NIH/NIEHS
    Targeting PTPalpha to Prevent Lung Fibrosis
    Role: Principal Investigator

    R01HL132950     (DOWNEY, GREGORY PAUL)Sep 23, 2016 - Jul 31, 2020
    NIH/NHLBI
    Checkpoint Function of PTPalpha in Pathological Fibrogenesis in the Lung
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Downey GP, Aschner Y. Taking It Off: New Insights into the Role of Tyrosine Phosphorylation-dependent Pathways in the Pathogenesis of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2017 Feb 15; 195(4):418-420. PMID: 28199155.
      View in: PubMed
    2. Downey GP, Aschner Y. Chasing the Lymph: New Clues for the Management of Idiopathic Plastic Bronchitis. Ann Am Thorac Soc. 2016 Oct; 13(10):1671-1673. PMID: 27726438.
      View in: PubMed
    3. McCormack FX, Gupta N, Finlay GR, Young LR, Taveira-DaSilva AM, Glasgow CG, Steagall WK, Johnson SR, Sahn SA, Ryu JH, Strange C, Seyama K, Sullivan EJ, Kotloff RM, Downey GP, Chapman JT, Han MK, D'Armiento JM, Inoue Y, Henske EP, Bissler JJ, Colby TV, Kinder BW, Wikenheiser-Brokamp KA, Brown KK, Cordier JF, Meyer C, Cottin V, Brozek JL, Smith K, Wilson KC, Moss J. Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management. Am J Respir Crit Care Med. 2016 Sep 15; 194(6):748-61. PMID: 27628078.
      View in: PubMed
    4. Aschner Y, Downey GP. Transforming Growth Factor-ß: Master Regulator of the Respiratory System in Health and Disease. Am J Respir Cell Mol Biol. 2016 May; 54(5):647-55. PMID: 26796672; PMCID: PMC4942197 [Available on 05/01/17].
    5. Schmidt EP, Kuebler WM, Lee WL, Downey GP. Adhesion Molecules: Master Controllers of the Circulatory System. Compr Physiol. 2016 Mar 15; 6(2):945-73. PMID: 27065171.
      View in: PubMed
    6. Wang Q, Wang Y, Downey GP, Plotnikov S, McCulloch CA. A ternary complex comprising FAK, PTPa and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts. Biochem J. 2016 Feb 15; 473(4):397-410. PMID: 26611753.
      View in: PubMed
    7. Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S1-2. PMID: 25830827; PMCID: PMC4430970.
    8. Baral P, Batra S, Zemans RL, Downey GP, Jeyaseelan S. Divergent functions of Toll-like receptors during bacterial lung infections. Am J Respir Crit Care Med. 2014 Oct 01; 190(7):722-32. PMID: 25033332; PMCID: PMC4299612.
    9. Aschner Y, Zemans RL, Yamashita CM, Downey GP. Matrix metalloproteinases and protein tyrosine kinases: potential novel targets in acute lung injury and ARDS. Chest. 2014 Oct; 146(4):1081-1091. PMID: 25287998; PMCID: PMC4188143.
    10. Leissinger M, Kulkarni R, Zemans RL, Downey GP, Jeyaseelan S. Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lung infection. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1461-8. PMID: 24707903; PMCID: PMC4226013.
    11. Yamashita CM, Radisky DC, Aschner Y, Downey GP. The importance of matrix metalloproteinase-3 in respiratory disorders. Expert Rev Respir Med. 2014 Aug; 8(4):411-21. PMID: 24869454.
      View in: PubMed
    12. Wang Q, Wang Y, Fritz D, Rajshankar D, Downey GP, McCulloch CA. Interactions of the protein-tyrosine phosphatase-a with the focal adhesion targeting domain of focal adhesion kinase are involved in interleukin-1 signaling in fibroblasts. J Biol Chem. 2014 Jun 27; 289(26):18427-41. PMID: 24821720; PMCID: PMC4140282.
    13. Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, Bratton DL, Riches DW. Tumor necrosis factor-a accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am J Respir Cell Mol Biol. 2014 Apr; 50(4):825-37. PMID: 24325577; PMCID: PMC4068926.
    14. Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Protein tyrosine phosphatase a mediates profibrotic signaling in lung fibroblasts through TGF-ß responsiveness. Am J Pathol. 2014 May; 184(5):1489-502. PMID: 24650563; PMCID: PMC4005983.
    15. Rajshankar D, Sima C, Wang Q, Goldberg SR, Kazembe M, Wang Y, Glogauer M, Downey GP, McCulloch CA. Role of PTPa in the destruction of periodontal connective tissues. PLoS One. 2013; 8(8):e70659. PMID: 23940616; PMCID: PMC3734242.
    16. Young L, Lee HS, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, Goldberg HJ, Downey GP, Swigris JJ, Taveira-DaSilva AM, Krischer JP, Trapnell BC, McCormack FX. Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial. Lancet Respir Med. 2013 Aug; 1(6):445-52. PMID: 24159565; PMCID: PMC3804556.
    17. Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP. Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):1-5. PMID: 23815257; PMCID: PMC3727882.
    18. Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP. The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J. 2014 Jan; 43(1):276-85. PMID: 23520315; PMCID: PMC4015132.
    19. Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP. Neutrophil Intercellular Communication in Acute Lung Injury: Emerging Roles of Microparticles and Gap Junctions. Am J Respir Cell Mol Biol. 2013 Mar 14. PMID: 23492190.
      View in: PubMed
    20. Wang Q, Siminovitch KA, Downey GP, McCulloch CA. Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLC? at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression. Biochem J. 2013 Feb 01; 449(3):771-82. PMID: 23145787.
      View in: PubMed
    21. Matute-Bello G, Downey GP. Reply: defining lung injury in animals. Am J Respir Cell Mol Biol. 2013 Feb; 48(2):267-8. PMID: 23487848.
      View in: PubMed
    22. Vij N, Downey GP. The yin and yang of cystic fibrosis transmembrane conductance regulator function: implications for chronic lung disease. Am J Respir Crit Care Med. 2013 Jan 15; 187(2):120-2. PMID: 23322792; PMCID: PMC3570650.
    23. Zemans RL, McClendon J, Aschner Y, Briones N, Young SK, Lau LF, Kahn M, Downey GP. Role of ß-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 15; 304(6):L415-27. PMID: 23316072; PMCID: PMC3602744.
    24. Rajshankar D, Downey GP, McCulloch CA. IL-1ß enhances cell adhesion to degraded fibronectin. FASEB J. 2012 Nov; 26(11):4429-44. PMID: 22829527; PMCID: PMC3475244.
    25. Stallings-Mann ML, Waldmann J, Zhang Y, Miller E, Gauthier ML, Visscher DW, Downey GP, Radisky ES, Fields AP, Radisky DC. Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Sci Transl Med. 2012 Jul 11; 4(142):142ra95. PMID: 22786680; PMCID: PMC3733503.
    26. Finigan JH, Downey GP, Kern JA. Human epidermal growth factor receptor signaling in acute lung injury. Am J Respir Cell Mol Biol. 2012 Oct; 47(4):395-404. PMID: 22652197; PMCID: PMC3488630.
    27. Flannagan RS, Jaumouillé V, Huynh KK, Plumb JD, Downey GP, Valvano MA, Grinstein S. Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42. Cell Microbiol. 2012 Feb; 14(2):239-54. PMID: 22023324.
      View in: PubMed
    28. Schmidt EP, Lee WL, Zemans RL, Yamashita C, Downey GP. On, around, and through: neutrophil-endothelial interactions in innate immunity. Physiology (Bethesda). 2011 Oct; 26(5):334-47. PMID: 22013192; PMCID: PMC3684246.
    29. Downey GP. Resolving the scar of pulmonary fibrosis. N Engl J Med. 2011 Sep 22; 365(12):1140-1. PMID: 21992127.
      View in: PubMed
    30. Zemans RL, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, De Langhe S, Reynolds SD, Mason RJ, Kahn M, Henson PM, Colgan SP, Downey GP. Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15990-5. PMID: 21880956; PMCID: PMC3179042.
    31. Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol. 2011 Oct; 179(4):1733-45. PMID: 21871427; PMCID: PMC3181358.
    32. Redente EF, Jacobsen KM, Solomon JJ, Lara AR, Faubel S, Keith RC, Henson PM, Downey GP, Riches DW. Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L510-8. PMID: 21743030; PMCID: PMC3191751.
    33. Wang Q, Downey GP, McCulloch CA. Focal adhesions and Ras are functionally and spatially integrated to mediate IL-1 activation of ERK. FASEB J. 2011 Oct; 25(10):3448-64. PMID: 21719512; PMCID: PMC3177576.
    34. Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM. An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol. 2011 May; 44(5):725-38. PMID: 21531958.
      View in: PubMed
    35. McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med. 2011 Apr 28; 364(17):1595-606. PMID: 21410393; PMCID: PMC3118601.
    36. Huynh KK, Plumb JD, Downey GP, Valvano MA, Grinstein S. Inactivation of macrophage Rab7 by Burkholderia cenocepacia. J Innate Immun. 2010; 2(6):522-33. PMID: 20829607; PMCID: PMC2982851.
    37. Wang Q, Rajshankar D, Laschinger C, Talior-Volodarsky I, Wang Y, Downey GP, McCulloch CA. Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expression. J Biol Chem. 2010 Jul 16; 285(29):22308-17. PMID: 20472558; PMCID: PMC2903391.
    38. Henson PM, Downey GP, Irvin CG. It's much more than just pretty pictures. Am J Respir Cell Mol Biol. 2010 May; 42(5):515-6. PMID: 20393072.
      View in: PubMed
    39. Juvet SC, Hwang D, Downey GP. Rare lung diseases III: pulmonary Langerhans' cell histiocytosis. Can Respir J. 2010 May-Jun; 17(3):e55-62. PMID: 20617216; PMCID: PMC2900147.
    40. Shimizu M, Saxena P, Konstantinov IE, Cherepanov V, Cheung MM, Wearden P, Zhangdong H, Schmidt M, Downey GP, Redington AN. Remote ischemic preconditioning decreases adhesion and selectively modifies functional responses of human neutrophils. J Surg Res. 2010 Jan; 158(1):155-61. PMID: 19540519.
      View in: PubMed
    41. Vandivier RW, Richens TR, Horstmann SA, deCathelineau AM, Ghosh M, Reynolds SD, Xiao YQ, Riches DW, Plumb J, Vachon E, Downey GP, Henson PM. Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L677-86. PMID: 19633071; PMCID: PMC2770781.
    42. Wang Q, Rajshankar D, Branch DR, Siminovitch KA, Herrera Abreu MT, Downey GP, McCulloch CA. Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling. J Biol Chem. 2009 Jul 31; 284(31):20763-72. PMID: 19497848; PMCID: PMC2742840.
    43. Fischer A, Swigris JJ, du Bois RM, Lynch DA, Downey GP, Cosgrove GP, Frankel SK, Fernandez-Perez ER, Gillis JZ, Brown KK. Anti-synthetase syndrome in ANA and anti-Jo-1 negative patients presenting with idiopathic interstitial pneumonia. Respir Med. 2009 Nov; 103(11):1719-24. PMID: 19497723; PMCID: PMC2857337.
    44. Voglis S, Quinn K, Tullis E, Liu M, Henriques M, Zubrinich C, Peñuelas O, Chan H, Silverman F, Cherepanov V, Orzech N, Khine AA, Cantin A, Slutsky AS, Downey GP, Zhang H. Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs. Am J Respir Crit Care Med. 2009 Jul 15; 180(2):159-66. PMID: 19406984; PMCID: PMC2714819.
    45. Suzuki T, Yamashita C, Zemans RL, Briones N, Van Linden A, Downey GP. Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway. Am J Respir Cell Mol Biol. 2009 Dec; 41(6):742-55. PMID: 19307610; PMCID: PMC2784410.
    46. Moraes TJ, Rafii B, Niessen F, Suzuki T, Martin R, Vachon E, Vogel W, Ruf W, O'Brodovich H, Downey GP. Protease-activated receptor (Par)1 alters bioelectric properties of distal lung epithelia without compromising barrier function. Exp Lung Res. 2009 Mar; 35(2):136-54. PMID: 19263282.
      View in: PubMed
    47. Kwok V, Vachon E, Downey GP. Use of fluorescent probes to detect lipid signaling intermediates in macrophages. Methods Mol Biol. 2009; 531:301-28. PMID: 19347325.
      View in: PubMed
    48. Zemans RL, Briones N, Young SK, Malcolm KC, Refaeli Y, Downey GP, Worthen GS. A novel method for long term bone marrow culture and genetic modification of murine neutrophils via retroviral transduction. J Immunol Methods. 2009 Jan 30; 340(2):102-15. PMID: 19010330; PMCID: PMC2633587.
    49. Zemans RL, Colgan SP, Downey GP. Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol. 2009 May; 40(5):519-35. PMID: 18978300; PMCID: PMC2677434.
    50. Juvet SC, Hwang D, Waddell TK, Downey GP. Rare lung disease II: pulmonary alveolar proteinosis. Can Respir J. 2008 May-Jun; 15(4):203-10. PMID: 18551202; PMCID: PMC2677953.
    51. Herrera Abreu MT, Penton PC, Kwok V, Vachon E, Shalloway D, Vidali L, Lee W, McCulloch CA, Downey GP. Tyrosine phosphatase PTPalpha regulates focal adhesion remodeling through Rac1 activation. Am J Physiol Cell Physiol. 2008 Apr; 294(4):C931-44. PMID: 18216165; PMCID: PMC4380481.
    52. Suzuki T, Chow CW, Downey GP. Role of innate immune cells and their products in lung immunopathology. Int J Biochem Cell Biol. 2008; 40(6-7):1348-61. PMID: 18272422.
      View in: PubMed
    53. Shalev I, Liu H, Koscik C, Bartczak A, Javadi M, Wong KM, Maknojia A, He W, Liu MF, Diao J, Winter E, Manuel J, McCarthy D, Cattral M, Gommerman J, Clark DA, Phillips MJ, Gorczynski RR, Zhang L, Downey G, Grant D, Cybulsky MI, Levy G. Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis. J Immunol. 2008 Jan 01; 180(1):249-60. PMID: 18097026.
      View in: PubMed
    54. Moraes TJ, Martin R, Plumb JD, Vachon E, Cameron CM, Danesh A, Kelvin DJ, Ruf W, Downey GP. Role of PAR2 in murine pulmonary pseudomonal infection. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L368-77. PMID: 18083764.
      View in: PubMed
    55. Zemans R, Downey GP. Role of caveolin-1 in regulation of inflammation: different strokes for different folks. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L175-7. PMID: 18055840.
      View in: PubMed
    56. Vachon E, Martin R, Kwok V, Cherepanov V, Chow CW, Doerschuk CM, Plumb J, Grinstein S, Downey GP. CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages. Blood. 2007 Dec 15; 110(13):4492-502. PMID: 17827392; PMCID: PMC2234794.
    57. Ding Z, Jia SH, Marshall JC, Downey GP, Waddell TK. Up-regulation of functional CXCR4 expression on human lymphocytes in sepsis. Crit Care Med. 2006 Dec; 34(12):3011-7. PMID: 17075377.
      View in: PubMed
    58. Juvet SC, McCormack FX, Kwiatkowski DJ, Downey GP. Molecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):398-408. PMID: 17099139; PMCID: PMC2176113.
    59. De Albuquerque N, Baig E, Ma X, Zhang J, He W, Rowe A, Habal M, Liu M, Shalev I, Downey GP, Gorczynski R, Butany J, Leibowitz J, Weiss SR, McGilvray ID, Phillips MJ, Fish EN, Levy GA. Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. J Virol. 2006 Nov; 80(21):10382-94. PMID: 17041219; PMCID: PMC1641767.
    60. Fialkow L, Wang Y, Downey GP. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med. 2007 Jan 15; 42(2):153-64. PMID: 17189821.
      View in: PubMed
    61. Pollock-BarZiv S, Cohen MM, Downey GP, Johnson SR, Sullivan E, McCormack FX. Air travel in women with lymphangioleiomyomatosis. Thorax. 2007 Feb; 62(2):176-80. PMID: 17040934; PMCID: PMC2111263.
    62. McCulloch CA, Downey GP, El-Gabalawy H. Signalling platforms that modulate the inflammatory response: new targets for drug development. Nat Rev Drug Discov. 2006 Oct; 5(10):864-76. PMID: 17016427.
      View in: PubMed
    63. Juvet SC, Hwang D, Downey GP. Rare lung diseases I--Lymphangioleiomyomatosis. Can Respir J. 2006 Oct; 13(7):375-80. PMID: 17036091; PMCID: PMC2683291.
    64. Greenwood HL, Singer PA, Downey GP, Martin DK, Thorsteinsdóttir H, Daar AS. Regenerative medicine and the developing world. PLoS Med. 2006 Sep; 3(9):e381. PMID: 16968130; PMCID: PMC1564180.
    65. Wang Q, Herrera Abreu MT, Siminovitch K, Downey GP, McCulloch CA. Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signaling. J Biol Chem. 2006 Oct 13; 281(41):31093-105. PMID: 16905534.
      View in: PubMed
    66. Guilbault C, Saeed Z, Downey GP, Radzioch D. Cystic fibrosis mouse models. Am J Respir Cell Mol Biol. 2007 Jan; 36(1):1-7. PMID: 16888286.
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    67. Maimon N, Paul N, Downey GP. Progressive dyspnea associated with a crazy-paving appearance on a chest computed tomography scan. Can Respir J. 2006 Jul-Aug; 13(5):269-71. PMID: 16896429; PMCID: PMC2683306.
    68. Moraes TJ, Downey GP. Death of the septic monocyte: is more better? Crit Care. 2006; 10(3):146. PMID: 16762041; PMCID: PMC1550960.
    69. Herrera Abreu MT, Wang Q, Vachon E, Suzuki T, Chow CW, Wang Y, Hong O, Villar J, McCulloch CA, Downey GP. Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions. J Cell Physiol. 2006 Apr; 207(1):132-43. PMID: 16250012.
      View in: PubMed
    70. Vachon E, Martin R, Plumb J, Kwok V, Vandivier RW, Glogauer M, Kapus A, Wang X, Chow CW, Grinstein S, Downey GP. CD44 is a phagocytic receptor. Blood. 2006 May 15; 107(10):4149-58. PMID: 16455948.
      View in: PubMed
    71. Moraes TJ, Zurawska JH, Downey GP. Neutrophil granule contents in the pathogenesis of lung injury. Curr Opin Hematol. 2006 Jan; 13(1):21-7. PMID: 16319683.
      View in: PubMed
    72. Fialkow L, Fochesatto Filho L, Bozzetti MC, Milani AR, Rodrigues Filho EM, Ladniuk RM, Pierozan P, de Moura RM, Prolla JC, Vachon E, Downey GP. Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome. Crit Care. 2006; 10(6):R155. PMID: 17092345; PMCID: PMC1794458.
    73. Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med. 2005 Dec 05; 202(11):1587-97. PMID: 16330817; PMCID: PMC2213338.
    74. Khine AA, Del Sorbo L, Vaschetto R, Voglis S, Tullis E, Slutsky AS, Downey GP, Zhang H. Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway. Blood. 2006 Apr 01; 107(7):2936-42. PMID: 16322472.
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    75. Aoki CR, Liu H, Downey GP, Mitchell J, Horner RL. Cyclic nucleotides modulate genioglossus and hypoglossal responses to excitatory inputs in rats. Am J Respir Crit Care Med. 2006 Mar 01; 173(5):555-65. PMID: 16322643.
      View in: PubMed
    76. Moraes TJ, Plumb J, Martin R, Vachon E, Cherepanov V, Koh A, Loeve C, Jongstra-Bilen J, Zurawska JH, Kus JV, Burrows LL, Grinstein S, Downey GP. Abnormalities in the pulmonary innate immune system in cystic fibrosis. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):364-74. PMID: 16293782; PMCID: PMC2644201.
    77. Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay MA, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP. Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol. 2005 Sep; 33(3):231-47. PMID: 15891109; PMCID: PMC2715314.
    78. Wang Q, Downey GP, Bajenova E, Abreu M, Kapus A, McCulloch CA. Mitochondrial function is a critical determinant of IL-1-induced ERK activation. FASEB J. 2005 May; 19(7):837-9. PMID: 15728661.
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    79. Peterson MD, Vlasova E, Di Ciano-Oliveira C, Downey GP, Cybulsky MI, Kapus A, Waddell TK. Monocyte-induced endothelial calcium signaling mediates early xenogeneic endothelial activation. Am J Transplant. 2005 Feb; 5(2):237-47. PMID: 15643983.
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    80. Pollock-BarZiv SM, Cohen MM, Maclean H, Downey GP. Patients' perceptions versus medical testing of function in women with lymphangioleiomyomatosis (LAM). Respir Med. 2005 Jul; 99(7):901-9. PMID: 15939253.
      View in: PubMed
    81. Wang Q, Downey GP, Herrera-Abreu MT, Kapus A, McCulloch CA. SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1. J Biol Chem. 2005 Mar 04; 280(9):8397-406. PMID: 15563458.
      View in: PubMed
    82. Rubin BB, Downey GP, Koh A, Degousee N, Ghomashchi F, Nallan L, Stefanski E, Harkin DW, Sun C, Smart BP, Lindsay TF, Cherepanov V, Vachon E, Kelvin D, Sadilek M, Brown GE, Yaffe MB, Plumb J, Grinstein S, Glogauer M, Gelb MH. Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. J Biol Chem. 2005 Mar 04; 280(9):7519-29. PMID: 15475363; PMCID: PMC2409062.
    83. Koehler DR, Downey GP, Sweezey NB, Tanswell AK, Hu J. Lung inflammation as a therapeutic target in cystic fibrosis. Am J Respir Cell Mol Biol. 2004 Oct; 31(4):377-81. PMID: 15381503.
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    84. Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, Downey GP, Mustelin T. Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol. 2004 Sep; 6(9):831-9. PMID: 15322554.
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    85. Sun CX, Downey GP, Zhu F, Koh AL, Thang H, Glogauer M. Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass. Blood. 2004 Dec 01; 104(12):3758-65. PMID: 15308574.
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    86. Konstantinov IE, Arab S, Kharbanda RK, Li J, Cheung MM, Cherepanov V, Downey GP, Liu PP, Cukerman E, Coles JG, Redington AN. The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics. 2004 Sep 16; 19(1):143-50. PMID: 15304621.
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    87. Ginzberg HH, Shannon PT, Suzuki T, Hong O, Vachon E, Moraes T, Abreu MT, Cherepanov V, Wang X, Chow CW, Downey GP. Leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and Akt. Am J Physiol Gastrointest Liver Physiol. 2004 Jul; 287(1):G286-98. PMID: 15194561.
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    88. Chow CW, Downey GP, Grinstein S. Measurements of phagocytosis and phagosomal maturation. Curr Protoc Cell Biol. 2004 May; Chapter 15:Unit 15.7. PMID: 18228442.
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    89. Cicutto L, Braidy C, Moloney S, Hutcheon M, Holness DL, Downey GP. Factors affecting attainment of paid employment after lung transplantation. J Heart Lung Transplant. 2004 Apr; 23(4):481-6. PMID: 15063409.
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    90. Cicutto LC, Downey GP. Biological markers in diagnosing, monitoring, and treating asthma: a focus on noninvasive measurements. AACN Clin Issues. 2004 Jan-Mar; 15(1):97-111. PMID: 14767368.
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    91. Moraes TJ, Downey GP. Neutrophil cell signaling in infection: role of phosphatidylinositide 3-kinase. Microbes Infect. 2003 Nov; 5(14):1293-8. PMID: 14613772.
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    92. Gilljam M, Moltyaner Y, Downey GP, Devlin R, Durie P, Cantin AM, Zielenski J, Tullis DE. Airway inflammation and infection in congenital bilateral absence of the vas deferens. Am J Respir Crit Care Med. 2004 Jan 15; 169(2):174-9. PMID: 14551163.
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    93. Chow CW, Herrera Abreu MT, Suzuki T, Downey GP. Oxidative stress and acute lung injury. Am J Respir Cell Mol Biol. 2003 Oct; 29(4):427-31. PMID: 14500253.
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    94. Wang Q, Downey GP, Choi C, Kapus A, McCulloch CA. IL-1 induced release of Ca2+ from internal stores is dependent on cell-matrix interactions and regulates ERK activation. FASEB J. 2003 Oct; 17(13):1898-900. PMID: 14519666.
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    95. Glogauer M, Marchal CC, Zhu F, Worku A, Clausen BE, Foerster I, Marks P, Downey GP, Dinauer M, Kwiatkowski DJ. Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol. 2003 Jun 01; 170(11):5652-7. PMID: 12759446.
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    96. MacGillivray M, Herrera-Abreu MT, Chow CW, Shek C, Wang Q, Vachon E, Feng GS, Siminovitch KA, McCulloch CA, Downey GP. The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts. J Biol Chem. 2003 Jul 18; 278(29):27190-8. PMID: 12721296.
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    97. Moraes TJ, Chow CW, Downey GP. Proteases and lung injury. Crit Care Med. 2003 Apr; 31(4 Suppl):S189-94. PMID: 12682439.
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    98. Tabata T, de Perrot M, Keshavjee S, Liu M, Downey GP, Waddell TK. Accommodation after lung xenografting from hamster to rat. Transplantation. 2003 Mar 15; 75(5):607-12. PMID: 12640297.
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    99. Ding Z, Issekutz TB, Downey GP, Waddell TK. L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration. Blood. 2003 Jun 01; 101(11):4245-52. PMID: 12609846.
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    100. Luo X, Belcastro R, Cabacungan J, Hannam V, Negus A, Wen Y, Plumb J, Hu J, Steer B, Koehler DR, Downey GP, Tanswell AK. Transfection of lung cells in vitro and in vivo: effect of antioxidants and intraliposomal bFGF. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L817-25. PMID: 12513969.
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    101. Zhang H, Downey GP, Suter PM, Slutsky AS, Ranieri VM. Conventional mechanical ventilation is associated with bronchoalveolar lavage-induced activation of polymorphonuclear leukocytes: a possible mechanism to explain the systemic consequences of ventilator-induced lung injury in patients with ARDS. Anesthesiology. 2002 Dec; 97(6):1426-33. PMID: 12459668.
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    102. Pollock-BarZiv SM, Cohen MM, Maclean H, Downey GP. Canadian respirologists' experience with lymphangioleiomyomatosis. Can Respir J. 2002 Nov-Dec; 9(6):413-6. PMID: 12522487.
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    103. Mahmudi-Azer S, Downey GP, Moqbel R. Translocation of the tetraspanin CD63 in association with human eosinophil mediator release. Blood. 2002 Jun 01; 99(11):4039-47. PMID: 12010805.
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    104. Lee WL, Downey GP. ICU Cornerstone: changing our view of blood transfusions. Crit Care. 2002 Aug; 6(4):291-2. PMID: 12225600; PMCID: PMC137307.
    105. de Perrot M, Keshavjee S, Tabata T, Liu M, Downey GP, Waddell TK. A simplified model for en bloc double lung xenotransplantation from hamster to rat. J Heart Lung Transplant. 2002 Feb; 21(2):286-9. PMID: 11834358.
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    106. Kruger JM, Fukushima T, Cherepanov V, Borregaard N, Loeve C, Shek C, Sharma K, Tanswell AK, Chow CW, Downey GP. Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides. J Biol Chem. 2002 Jan 25; 277(4):2620-8. PMID: 11711529.
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