Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Thomas Jansson

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OB/GYN RS GENERAL OPS
    Other Positions
    TitleDivision Head
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-OB/GYN RS GENERAL OPS


    Collapse Research 
    Collapse research activities and funding
    R03HD058032     (JANSSON, THOMAS)May 15, 2008 - Apr 30, 2012
    NIH/NICHD
    Development of a mouse model of obesity in pregnancy
    Role: Principal Investigator

    R01HD065007     (JANSSON, THOMAS)Dec 25, 2010 - May 31, 2023
    NIH/NICHD
    Placental adiponectin signaling and fetal programming in maternal obesity
    Role: Principal Investigator

    R01HD068370     (JANSSON, THOMAS)Jul 25, 2011 - Jun 30, 2016
    NIH/NICHD
    Molecular Mechanisms Regulating Placental Nutrient Transporters
    Role: Principal Investigator

    R21HD071306     (JANSSON, THOMAS)Apr 1, 2012 - Mar 31, 2014
    NIH/NICHD
    Molecular Mechanisms Linking Placental Nutrient Sensing and Fetal Programming
    Role: Principal Investigator

    R03HD078313     (JANSSON, THOMAS)Apr 1, 2014 - Mar 31, 2016
    NIH/NICHD
    IGFBP-1 hyperphosphorylation in IUGR: Role of mTOR and CK2
    Role: Principal Investigator

    R24OD016724     (JANSSON, THOMAS)Jun 1, 2014 - Mar 31, 2018
    NIH
    A Novel Mouse Model of Obesity in Pregnancy
    Role: Principal Investigator

    R01HD078376     (JANSSON, THOMAS)Jul 1, 2014 - Apr 30, 2019
    NIH/NICHD
    mTOR as a trophoblast folate sensor
    Role: Principal Investigator

    R13HD084096     (JANSSON, THOMAS)Mar 16, 2015 - Feb 28, 2020
    NIH/NICHD
    Placenta Association of the Americas Conference Grant
    Role: Principal Investigator

    R01HD089980     (JANSSON, THOMAS)Sep 1, 2017 - Jun 30, 2022
    NIH/NICHD
    Decidual nutrient sensing and IGFBP-1 phosphorylation in placental insufficiency
    Role: Principal Investigator

    R03HD093950     (JANSSON, THOMAS)Jul 1, 2018 - Jun 30, 2020
    NIH/NICHD
    Regulation of IGFBP-1 Phosphorylation in Fetal Development
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. James-Allan LB, Rosario FJ, Barner K, Lai A, Guanzon D, McIntyre HD, Lappas M, Powell TL, Salomon C, Jansson T. Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes. FASEB J. 2020 Mar 10. PMID: 32154621.
      View in: PubMed
    2. James-Allan LB, Teal S, Powell TL, Jansson T. Changes in Placental Nutrient Transporter Protein Expression and Activity Across Gestation in Normal and Obese Women. Reprod Sci. 2020 Feb 18. PMID: 32072607.
      View in: PubMed
    3. Jansson T, Castillo-Castrejon M, Gupta MB, Powell TL, Rosario FJ. Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction. Clin Sci (Lond). 2020 Jan 17; 134(1):53-70. PMID: 31825077.
      View in: PubMed
    4. Stremming J, Jansson T, Powell TL, Rozance PJ, Brown LD. Reduced Na+ K+ -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity. J Physiol. 2020 Jan 07. PMID: 31909825.
      View in: PubMed
    5. Vaughan OR, Thompson F, Lorca RA, Julian CG, Powell TL, Moore LG, Jansson T. Effect of high altitude on human placental amino acid transport. J Appl Physiol (1985). 2020 Jan 01; 128(1):127-133. PMID: 31804891.
      View in: PubMed
    6. Jessel RH, Rosario FJ, Chen YY, Erickson K, Teal SB, Kramer A, Cotton E, Ryan S, Jansson T, Powell TL. Decreased placental folate transporter expression and activity in first and second trimester in obese mothers. J Nutr Biochem. 2020 Mar; 77:108305. PMID: 31926453.
      View in: PubMed
    7. Vyas V, Guerra DD, Bok R, Powell T, Jansson T, Hurt KJ. Adiponectin links maternal metabolism to uterine contractility. FASEB J. 2019 Dec; 33(12):14588-14601. PMID: 31665924.
      View in: PubMed
    8. Castillo-Castrejon M, Jansson T, Powell TL. No evidence of attenuation of placental insulin-stimulated Akt phosphorylation and amino acid transport in maternal obesity and gestational diabetes mellitus. Am J Physiol Endocrinol Metab. 2019 12 01; 317(6):E1037-E1049. PMID: 31573844.
      View in: PubMed
    9. Ramzan AA, Bitler BG, Hicks D, Barner K, Qamar L, Behbakht K, Powell T, Jansson T, Wilson H. Adiponectin receptor agonist AdipoRon induces apoptotic cell death and suppresses proliferation in human ovarian cancer cells. Mol Cell Biochem. 2019 Nov; 461(1-2):37-46. PMID: 31292831.
      View in: PubMed
    10. James-Allan LB, Arbet J, Teal SB, Powell TL, Jansson T. Insulin stimulates GLUT4 trafficking to the syncytiotrophoblast basal plasma membrane in the human placenta. J Clin Endocrinol Metab. 2019 May 21. PMID: 31112275.
      View in: PubMed
    11. Vaughan OR, Rosario FJ, Powell TL, Jansson T. Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring. Int J Obes (Lond). 2020 Feb; 44(2):488-499. PMID: 31076636.
      View in: PubMed
    12. Gupta MB, Jansson T. Novel roles of mechanistic target of rapamycin signaling in regulating fetal growth†. Biol Reprod. 2019 04 01; 100(4):872-884. PMID: 30476008.
      View in: PubMed
    13. Michelsen TM, Holme AM, Holm MB, Roland MC, Haugen G, Powell TL, Jansson T, Henriksen T. Uteroplacental Glucose Uptake and Fetal Glucose Consumption: A Quantitative Study in Human Pregnancies. J Clin Endocrinol Metab. 2019 03 01; 104(3):873-882. PMID: 30339207.
      View in: PubMed
    14. Ferchaud-Roucher V, Barner K, Jansson T, Powell TL. Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti-inflammatory and insulin-sensitizing properties. FASEB J. 2019 May; 33(5):6643-6654. PMID: 30811959.
      View in: PubMed
    15. Gupta MB, Abu Shehab M, Nygard K, Biggar K, Singal SS, Santoro N, Powell TL, Jansson T. IUGR Is Associated With Marked Hyperphosphorylation of Decidual and Maternal Plasma IGFBP-1. J Clin Endocrinol Metab. 2019 02 01; 104(2):408-422. PMID: 30124960.
      View in: PubMed
    16. Chassen S, Jansson T. Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR. Biochim Biophys Acta Mol Basis Dis. 2020 Feb 01; 1866(2):165373. PMID: 30684642.
      View in: PubMed
    17. Rosario FJ, Gupta MB, Myatt L, Powell TL, Glenn JP, Cox L, Jansson T. Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis. Sci Rep. 2019 01 22; 9(1):246. PMID: 30670706.
      View in: PubMed
    18. Ferchaud-Roucher V, Kramer A, Silva E, Pantham P, Weintraub ST, Jansson T, Powell TL. A potential role for lysophosphatidylcholine in the delivery of long chain polyunsaturated fatty acids to the fetal circulation. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 03; 1864(3):394-402. PMID: 30572119.
      View in: PubMed
    19. Nair S, Jayabalan N, Guanzon D, Palma C, Scholz-Romero K, Elfeky O, Zuñiga F, Ormazabal V, Diaz E, Rice GE, Duncombe G, Jansson T, McIntyre HD, Lappas M, Salomon C. Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity. Clin Sci (Lond). 2018 11 30; 132(22):2451-2467. PMID: 30254065.
      View in: PubMed
    20. Paulsen ME, Rosario FJ, Wesolowski SR, Powell TL, Jansson T. Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring. FASEB J. 2019 02; 33(2):2899-2909. PMID: 30346829.
      View in: PubMed
    21. Michelsen TM, Henriksen T, Reinhold D, Powell TL, Jansson T. The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling. FASEB J. 2019 02; 33(2):2944-2956. PMID: 30335547.
      View in: PubMed
    22. Capobianco E, Gomez Ribot D, Fornes D, Powell TL, Levieux C, Jansson T, Jawerbaum A. Diet Enriched with Olive Oil Attenuates Placental Dysfunction in Rats with Gestational Diabetes Induced by Intrauterine Programming. Mol Nutr Food Res. 2018 10; 62(19):e1800263. PMID: 29939470.
      View in: PubMed
    23. Chen YY, Gupta MB, Grattton R, Powell TL, Jansson T. Down-regulation of placental folate transporters in intrauterine growth restriction. J Nutr Biochem. 2018 09; 59:136-141. PMID: 29986308.
      View in: PubMed
    24. Roberti SL, Higa R, White V, Powell TL, Jansson T, Jawerbaum A. Critical role of mTOR, PPAR? and PPARd signaling in regulating early pregnancy decidual function, embryo viability and feto-placental growth. Mol Hum Reprod. 2018 06 01; 24(6):327-340. PMID: 29538677.
      View in: PubMed
    25. Singal SS, Nygard K, Gratton R, Jansson T, Gupta MB. Increased Insulin-like Growth Factor Binding Protein-1 Phosphorylation in Decidualized Stromal Mesenchymal Cells in Human Intrauterine Growth Restriction Placentas. J Histochem Cytochem. 2018 09; 66(9):617-630. PMID: 29718759.
      View in: PubMed
    26. Chassen SS, Ferchaud-Roucher V, Gupta MB, Jansson T, Powell TL. Alterations in placental long chain polyunsaturated fatty acid metabolism in human intrauterine growth restriction. Clin Sci (Lond). 2018 03 15; 132(5):595-607. PMID: 29463583.
      View in: PubMed
    27. Capobianco E, Fornes D, Roberti SL, Powell TL, Jansson T, Jawerbaum A. Supplementation with polyunsaturated fatty acids in pregnant rats with mild diabetes normalizes placental PPAR? and mTOR signaling in female offspring developing gestational diabetes. J Nutr Biochem. 2018 03; 53:39-47. PMID: 29190548.
      View in: PubMed
    28. Dimasuay KG, Gong L, Rosario F, McBryde E, Spelman T, Glazier J, Rogerson SJ, Beeson JG, Jansson T, Devenish RJ, Boeuf P. Impaired placental autophagy in placental malaria. PLoS One. 2017; 12(11):e0187291. PMID: 29125872.
      View in: PubMed
    29. Singal SS, Nygard K, Dhruv MR, Biggar K, Shehab MA, Li SS, Jansson T, Gupta MB. Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2ß, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay. Am J Pathol. 2018 01; 188(1):111-124. PMID: 29037858.
      View in: PubMed
    30. Holm MB, Bastani NE, Holme AM, Zucknick M, Jansson T, Refsum H, Mørkrid L, Blomhoff R, Henriksen T, Michelsen TM. Uptake and release of amino acids in the fetal-placental unit in human pregnancies. PLoS One. 2017; 12(10):e0185760. PMID: 28982184.
      View in: PubMed
    31. Fornes R, Maliqueo M, Hu M, Hadi L, Jimenez-Andrade JM, Ebefors K, Nyström J, Labrie F, Jansson T, Benrick A, Stener-Victorin E. The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams. Sci Rep. 2017 08 14; 7(1):8066. PMID: 28808352.
      View in: PubMed
    32. Rosario FJ, Nathanielsz PW, Powell TL, Jansson T. Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice. Sci Rep. 2017 06 21; 7(1):3982. PMID: 28638048.
      View in: PubMed
    33. Silva E, Rosario FJ, Powell TL, Jansson T. Mechanistic Target of Rapamycin Is a Novel Molecular Mechanism Linking Folate Availability and Cell Function. J Nutr. 2017 07; 147(7):1237-1242. PMID: 28592519.
      View in: PubMed
    34. Ferchaud-Roucher V, Rudolph MC, Jansson T, Powell TL. Fatty acid and lipid profiles in primary human trophoblast over 90h in culture. Prostaglandins Leukot Essent Fatty Acids. 2017 Jun; 121:14-20. PMID: 28651693.
      View in: PubMed
    35. Rosario FJ, Powell TL, Jansson T. mTOR folate sensing links folate availability to trophoblast cell function. J Physiol. 2017 07 01; 595(13):4189-4206. PMID: 28374905.
      View in: PubMed
    36. Díaz P, Dimasuay KG, Koele-Schmidt L, Jang B, Barbour LA, Jansson T, Powell TL. Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight. Placenta. 2017 Sep; 57:52-59. PMID: 28864019.
      View in: PubMed
    37. Shehab MA, Biggar K, Singal SS, Nygard K, Shun-Cheng Li S, Jansson T, Gupta MB. Exposure of decidualized HIESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity. Mol Cell Endocrinol. 2017 09 05; 452:1-14. PMID: 28435049.
      View in: PubMed
    38. Vaughan OR, Rosario FJ, Powell TL, Jansson T. Regulation of Placental Amino Acid Transport and Fetal Growth. Prog Mol Biol Transl Sci. 2017; 145:217-251. PMID: 28110752.
      View in: PubMed
    39. Dimasuay KG, Aitken EH, Rosario F, Njie M, Glazier J, Rogerson SJ, Fowkes FJ, Beeson JG, Powell T, Jansson T, Boeuf P. Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight. BMC Med. 2017 Jan 03; 15(1):1. PMID: 28049467.
      View in: PubMed
    40. Chen YY, Powell TL, Jansson T. 1,25-Dihydroxy vitamin D3 stimulates system A amino acid transport in primary human trophoblast cells. Mol Cell Endocrinol. 2017 02 15; 442:90-97. PMID: 27956114.
      View in: PubMed
    41. Jansson T. Placenta plays a critical role in maternal-fetal resource allocation. Proc Natl Acad Sci U S A. 2016 10 04; 113(40):11066-11068. PMID: 27660237.
      View in: PubMed
    42. Pantham P, Rosario FJ, Weintraub ST, Nathanielsz PW, Powell TL, Li C, Jansson T. Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons. Biol Reprod. 2016 11; 95(5):98. PMID: 27605346.
      View in: PubMed
    43. Rosario FJ, Powell TL, Jansson T. Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-a and the RFC. Sci Rep. 2016 08 26; 6:31705. PMID: 27562465.
      View in: PubMed
    44. Fornes R, Hu M, Maliqueo M, Kokosar M, Benrick A, Carr D, Billig H, Jansson T, Manni L, Stener-Victorin E. Maternal testosterone and placental function: Effect of electroacupuncture on placental expression of angiogenic markers and fetal growth. Mol Cell Endocrinol. 2016 09 15; 433:1-11. PMID: 27208621.
      View in: PubMed
    45. Lager S, Ramirez VI, Gaccioli F, Jang B, Jansson T, Powell TL. Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight/obese women. Placenta. 2016 Apr; 40:60-6. PMID: 27016784.
      View in: PubMed
    46. Dimasuay KG, Boeuf P, Powell TL, Jansson T. Placental Responses to Changes in the Maternal Environment Determine Fetal Growth. Front Physiol. 2016; 7:12. PMID: 26858656.
      View in: PubMed
    47. Aye IL, Rosario FJ, Powell TL, Jansson T. Reply to Carbillon: Fetal/placental weight ratio and placental function. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):E261. PMID: 26755612.
      View in: PubMed
    48. Capobianco E, Fornes D, Linenberg I, Powell TL, Jansson T, Jawerbaum A. A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth. Mol Cell Endocrinol. 2016 Feb 15; 422:221-232. PMID: 26747729.
      View in: PubMed
    49. Damerill I, Biggar KK, Abu Shehab M, Li SS, Jansson T, Gupta MB. Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition. Mol Endocrinol. 2016 Feb; 30(2):201-16. PMID: 26714229.
      View in: PubMed
    50. Malkani N, Biggar K, Shehab MA, Li SS, Jansson T, Gupta MB. Increased IGFBP-1 phosphorylation in response to leucine deprivation is mediated by CK2 and PKC. Mol Cell Endocrinol. 2016 Apr 15; 425:48-60. PMID: 26733150.
      View in: PubMed
    51. Rosario FJ, Dimasuay KG, Kanai Y, Powell TL, Jansson T. Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2. Clin Sci (Lond). 2016 Apr 01; 130(7):499-512. PMID: 26608079.
      View in: PubMed
    52. Díaz P, Harris J, Rosario FJ, Powell TL, Jansson T. Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15; 309(12):R1569-77. PMID: 26491104.
      View in: PubMed
    53. Rosario FJ, Powell TL, Jansson T. Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 01; 310(1):R87-93. PMID: 26491103.
      View in: PubMed
    54. Aye IL, Jansson T, Powell TL. TNF-a stimulates System A amino acid transport in primary human trophoblast cells mediated by p38 MAPK signaling. Physiol Rep. 2015 Oct; 3(10). PMID: 26508738.
      View in: PubMed
    55. Aye IL, Rosario FJ, Powell TL, Jansson T. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12858-63. PMID: 26417088.
      View in: PubMed
    56. Chen YY, Rosario FJ, Shehab MA, Powell TL, Gupta MB, Jansson T. Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR. Clin Sci (Lond). 2015 Dec; 129(12):1131-41. PMID: 26374858.
      View in: PubMed
    57. Pantham P, Rosario FJ, Nijland M, Cheung A, Nathanielsz PW, Powell TL, Galan HL, Li C, Jansson T. Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon. Am J Physiol Regul Integr Comp Physiol. 2015 Oct; 309(7):R740-6. PMID: 26246504.
      View in: PubMed
    58. Rosario FJ, Kanai Y, Powell TL, Jansson T. Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth. Obesity (Silver Spring). 2015 Aug; 23(8):1663-70. PMID: 26193061.
      View in: PubMed
    59. Gaccioli F, Aye IL, Roos S, Lager S, Ramirez VI, Kanai Y, Powell TL, Jansson T. Expression and functional characterisation of System L amino acid transporters in the human term placenta. Reprod Biol Endocrinol. 2015 Jun 09; 13:57. PMID: 26050671.
      View in: PubMed
    60. Malkani N, Jansson T, Gupta MB. IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway. Mol Cell Endocrinol. 2015 Sep 05; 412:182-95. PMID: 25957086.
      View in: PubMed
    61. Lager S, Jansson T, Powell TL. Reply to "Letter to the editor: 'fatty acids and placental transport: insight or in vitro artifact?'". Am J Physiol Cell Physiol. 2014 Dec 01; 307(11):C1069. PMID: 25452383.
      View in: PubMed
    62. Lager S, Jansson T, Powell TL. Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids. Am J Physiol Cell Physiol. 2014 Oct 15; 307(8):C738-44. PMID: 25143349.
      View in: PubMed
    63. Acosta O, Ramirez VI, Lager S, Gaccioli F, Dudley DJ, Powell TL, Jansson T. Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers. Am J Obstet Gynecol. 2015 Feb; 212(2):227.e1-7. PMID: 25132463.
      View in: PubMed
    64. Díaz P, Powell TL, Jansson T. The role of placental nutrient sensing in maternal-fetal resource allocation. Biol Reprod. 2014 Oct; 91(4):82. PMID: 25122064.
      View in: PubMed
    65. Aye IL, Lager S, Ramirez VI, Gaccioli F, Dudley DJ, Jansson T, Powell TL. Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways. Biol Reprod. 2014 Jun; 90(6):129. PMID: 24759787.
      View in: PubMed
    66. Aye IL, Gao X, Weintraub ST, Jansson T, Powell TL. Adiponectin inhibits insulin function in primary trophoblasts by PPARa-mediated ceramide synthesis. Mol Endocrinol. 2014 Apr; 28(4):512-24. PMID: 24606127.
      View in: PubMed
    67. Lager S, Samulesson AM, Taylor PD, Poston L, Powell TL, Jansson T. Diet-induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling. Physiol Rep. 2014 Feb 01; 2(2):e00242. PMID: 24744907.
      View in: PubMed
    68. Abu Shehab M, Damerill I, Shen T, Rosario FJ, Nijland M, Nathanielsz PW, Kamat A, Jansson T, Gupta MB. Liver mTOR controls IGF-I bioavailability by regulation of protein kinase CK2 and IGFBP-1 phosphorylation in fetal growth restriction. Endocrinology. 2014 Apr; 155(4):1327-39. PMID: 24437487.
      View in: PubMed
    69. Kavitha JV, Rosario FJ, Nijland MJ, McDonald TJ, Wu G, Kanai Y, Powell TL, Nathanielsz PW, Jansson T. Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon. FASEB J. 2014 Mar; 28(3):1294-305. PMID: 24334703.
      View in: PubMed
    70. Gaccioli F, White V, Capobianco E, Powell TL, Jawerbaum A, Jansson T. Maternal overweight induced by a diet with high content of saturated fat activates placental mTOR and eIF2alpha signaling and increases fetal growth in rats. Biol Reprod. 2013 Oct; 89(4):96. PMID: 24006279.
      View in: PubMed
    71. Cox LA, Li C, Glenn JP, Lange K, Spradling KD, Nathanielsz PW, Jansson T. Expression of the placental transcriptome in maternal nutrient reduction in baboons is dependent on fetal sex. J Nutr. 2013 Nov; 143(11):1698-708. PMID: 24047701.
      View in: PubMed
    72. Jansson T, Powell TL. Role of placental nutrient sensing in developmental programming. Clin Obstet Gynecol. 2013 Sep; 56(3):591-601. PMID: 23703224.
      View in: PubMed
    73. Aye IL, Jansson T, Powell TL. Interleukin-1ß inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts. Mol Cell Endocrinol. 2013 Dec 05; 381(1-2):46-55. PMID: 23891856.
      View in: PubMed
    74. Li C, Shu ZJ, Lee S, Gupta MB, Jansson T, Nathanielsz PW, Kamat A. Effects of maternal nutrient restriction, intrauterine growth restriction, and glucocorticoid exposure on phosphoenolpyruvate carboxykinase-1 expression in fetal baboon hepatocytes in vitro. J Med Primatol. 2013 Aug; 42(4):211-9. PMID: 23600855.
      View in: PubMed
    75. Lager S, Gaccioli F, Ramirez VI, Jones HN, Jansson T, Powell TL. Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4. J Lipid Res. 2013 Mar; 54(3):725-33. PMID: 23275648.
      View in: PubMed
    76. Rosario FJ, Kanai Y, Powell TL, Jansson T. Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells. J Physiol. 2013 Feb 01; 591(3):609-25. PMID: 23165769.
      View in: PubMed
    77. Jansson N, Rosario FJ, Gaccioli F, Lager S, Jones HN, Roos S, Jansson T, Powell TL. Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies. J Clin Endocrinol Metab. 2013 Jan; 98(1):105-13. PMID: 23150676.
      View in: PubMed
    78. McDonald TJ, Wu G, Nijland MJ, Jenkins SL, Nathanielsz PW, Jansson T. Effect of 30% nutrient restriction in the first half of gestation on maternal and fetal baboon serum amino acid concentrations. Br J Nutr. 2013 Apr 28; 109(8):1382-8. PMID: 23046718.
      View in: PubMed
    79. Sun M, Maliqueo M, Benrick A, Johansson J, Shao R, Hou L, Jansson T, Wu X, Stener-Victorin E. Maternal androgen excess reduces placental and fetal weights, increases placental steroidogenesis, and leads to long-term health effects in their female offspring. Am J Physiol Endocrinol Metab. 2012 Dec 01; 303(11):E1373-85. PMID: 23047983.
      View in: PubMed
    80. Rosario FJ, Schumacher MA, Jiang J, Kanai Y, Powell TL, Jansson T. Chronic maternal infusion of full-length adiponectin in pregnant mice down-regulates placental amino acid transporter activity and expression and decreases fetal growth. J Physiol. 2012 Mar 15; 590(6):1495-509. PMID: 22289908.
      View in: PubMed
    81. Carter MF, Powell TL, Li C, Myatt L, Dudley D, Nathanielsz P, Jansson T. Fetal serum folate concentrations and placental folate transport in obese women. Am J Obstet Gynecol. 2011 Jul; 205(1):83.e17-25. PMID: 21514551.
      View in: PubMed
    82. Rosario FJ, Jansson N, Kanai Y, Prasad PD, Powell TL, Jansson T. Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters. Endocrinology. 2011 Mar; 152(3):1119-29. PMID: 21285325.
      View in: PubMed
    83. Jones HN, Jansson T, Powell TL. Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells. Diabetes. 2010 May; 59(5):1161-70. PMID: 20150288.
      View in: PubMed
    84. Jansson T, Myatt L, Powell TL. The role of trophoblast nutrient and ion transporters in the development of pregnancy complications and adult disease. Curr Vasc Pharmacol. 2009 Oct; 7(4):521-33. PMID: 19485888.
      View in: PubMed
    85. Jansson T. Novel mechanism causing restricted fetal growth: does maternal homocysteine impair placental amino acid transport? J Physiol. 2009 Sep 01; 587(Pt 17):4123. PMID: 19720845.
      View in: PubMed
    86. Roos S, Powell TL, Jansson T. Placental mTOR links maternal nutrient availability to fetal growth. Biochem Soc Trans. 2009 Feb; 37(Pt 1):295-8. PMID: 19143650.
      View in: PubMed
    87. Jones HN, Woollett LA, Barbour N, Prasad PD, Powell TL, Jansson T. High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J. 2009 Jan; 23(1):271-8. PMID: 18827021.
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    88. Jansson N, Nilsfelt A, Gellerstedt M, Wennergren M, Rossander-Hulthén L, Powell TL, Jansson T. Maternal hormones linking maternal body mass index and dietary intake to birth weight. Am J Clin Nutr. 2008 Jun; 87(6):1743-9. PMID: 18541564.
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    89. Jansson T, Powell TL. Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin Sci (Lond). 2007 Jul; 113(1):1-13. PMID: 17536998.
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    90. Roos S, Jansson N, Palmberg I, Säljö K, Powell TL, Jansson T. Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. J Physiol. 2007 Jul 01; 582(Pt 1):449-59. PMID: 17463046.
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    91. Ericsson A, Säljö K, Sjöstrand E, Jansson N, Prasad PD, Powell TL, Jansson T. Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport. J Physiol. 2007 Jun 15; 581(Pt 3):1323-32. PMID: 17430988.
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    92. Magnusson-Olsson AL, Lager S, Jacobsson B, Jansson T, Powell TL. Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E24-30. PMID: 17299085.
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    93. Hultman K, Alexanderson C, Mannerås L, Sandberg M, Holmäng A, Jansson T. Maternal taurine supplementation in the late pregnant rat stimulates postnatal growth and induces obesity and insulin resistance in adult offspring. J Physiol. 2007 Mar 15; 579(Pt 3):823-33. PMID: 17204495.
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    94. Jansson N, Pettersson J, Haafiz A, Ericsson A, Palmberg I, Tranberg M, Ganapathy V, Powell TL, Jansson T. Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet. J Physiol. 2006 Nov 01; 576(Pt 3):935-46. PMID: 16916910.
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    95. Dahlgren J, Samuelsson AM, Jansson T, Holmäng A. Interleukin-6 in the maternal circulation reaches the rat fetus in mid-gestation. Pediatr Res. 2006 Aug; 60(2):147-51. PMID: 16864694.
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    96. Settle P, Sibley CP, Doughty IM, Johnston T, Glazier JD, Powell TL, Jansson T, D'Souza SW. Placental lactate transporter activity and expression in intrauterine growth restriction. J Soc Gynecol Investig. 2006 Jul; 13(5):357-63. PMID: 16814165.
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    97. Sibley CP, Turner MA, Cetin I, Ayuk P, Boyd CA, D'Souza SW, Glazier JD, Greenwood SL, Jansson T, Powell T. Placental phenotypes of intrauterine growth. Pediatr Res. 2005 Nov; 58(5):827-32. PMID: 16183820.
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    98. Ericsson A, Hamark B, Jansson N, Johansson BR, Powell TL, Jansson T. Hormonal regulation of glucose and system A amino acid transport in first trimester placental villous fragments. Am J Physiol Regul Integr Comp Physiol. 2005 Mar; 288(3):R656-62. PMID: 15539610.
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    99. Jansson T, Wennergren M, Powell T. [Pregnancy complications can impair placental transport systems. Aberrant fetal growth, for example in diabetes, is only now beginning to be understood]. Lakartidningen. 2003 Aug 07; 100(32-33):2508-11. PMID: 12959009.
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    100. Jansson T, Ekstrand Y, Björn C, Wennergren M, Powell TL. Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetes. Diabetes. 2002 Jul; 51(7):2214-9. PMID: 12086952.
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