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Thomas Jansson

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OB/GYN BRS

    Collapse Research 
    Collapse research activities and funding
    R03HD058032     (JANSSON, THOMAS)May 15, 2008 - Apr 30, 2012
    NIH/NICHD
    Development of a mouse model of obesity in pregnancy
    Role: Principal Investigator

    R01HD065007     (JANSSON, THOMAS)Dec 25, 2010 - Nov 30, 2015
    NIH/NICHD
    Adiponectin, placental nutrient transport and fetal growth
    Role: Principal Investigator

    R01HD068370     (JANSSON, THOMAS)Jul 25, 2011 - Jun 30, 2016
    NIH/NICHD
    Molecular Mechanisms Regulating Placental Nutrient Transporters
    Role: Principal Investigator

    R21HD071306     (JANSSON, THOMAS)Apr 1, 2012 - Mar 31, 2014
    NIH/NICHD
    Molecular Mechanisms Linking Placental Nutrient Sensing and Fetal Programming
    Role: Principal Investigator

    R03HD078313     (JANSSON, THOMAS)Apr 1, 2014 - Mar 31, 2016
    NIH/NICHD
    IGFBP-1 hyperphosphorylation in IUGR: Role of mTOR and CK2
    Role: Principal Investigator

    R24OD016724     (JANSSON, THOMAS)Jun 1, 2014 - Mar 31, 2018
    NIH
    A Novel Mouse Model of Obesity in Pregnancy
    Role: Principal Investigator

    R01HD078376     (JANSSON, THOMAS)Jul 1, 2014 - Apr 30, 2019
    NIH/NICHD
    mTOR as a trophoblast folate sensor
    Role: Principal Investigator

    R13HD084096     (JANSSON, THOMAS)Mar 16, 2015 - Feb 28, 2020
    NIH/NICHD
    Placenta Association of the Americas Conference Grant
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rosario FJ, Nathanielsz PW, Powell TL, Jansson T. Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice. Sci Rep. 2017 Jun 21; 7(1):3982. PMID: 28638048.
      View in: PubMed
    2. Ferchaud-Roucher V, Rudolph MC, Jansson T, Powell TL. Fatty acid and lipid profiles in primary human trophoblast over 90h in culture. Prostaglandins Leukot Essent Fatty Acids. 2017 Jun; 121:14-20. PMID: 28651693.
      View in: PubMed
    3. Rosario FJ, Powell TL, Jansson T. mTOR folate sensing links folate availability to trophoblast cell function. J Physiol. 2017 Jul 01; 595(13):4189-4206. PMID: 28374905.
      View in: PubMed
    4. Shehab MA, Biggar K, Singal SS, Nygard K, Shun-Cheng Li S, Jansson T, Gupta MB. Exposure of decidualized HIESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity. Mol Cell Endocrinol. 2017 Sep 05; 452:1-14. PMID: 28435049.
      View in: PubMed
    5. Vaughan OR, Rosario FJ, Powell TL, Jansson T. Regulation of Placental Amino Acid Transport and Fetal Growth. Prog Mol Biol Transl Sci. 2017; 145:217-251. PMID: 28110752.
      View in: PubMed
    6. Dimasuay KG, Aitken EH, Rosario F, Njie M, Glazier J, Rogerson SJ, Fowkes FJ, Beeson JG, Powell T, Jansson T, Boeuf P. Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight. BMC Med. 2017 Jan 03; 15(1):1. PMID: 28049467.
      View in: PubMed
    7. Chen YY, Powell TL, Jansson T. 1,25-Dihydroxy vitamin D3 stimulates system A amino acid transport in primary human trophoblast cells. Mol Cell Endocrinol. 2017 Feb 15; 442:90-97. PMID: 27956114.
      View in: PubMed
    8. Jansson T. Placenta plays a critical role in maternal-fetal resource allocation. Proc Natl Acad Sci U S A. 2016 Oct 04; 113(40):11066-11068. PMID: 27660237.
      View in: PubMed
    9. Pantham P, Rosario FJ, Weintraub ST, Nathanielsz PW, Powell TL, Li C, Jansson T. Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons. Biol Reprod. 2016 Nov; 95(5):98. PMID: 27605346.
      View in: PubMed
    10. Rosario FJ, Powell TL, Jansson T. Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-a and the RFC. Sci Rep. 2016 Aug 26; 6:31705. PMID: 27562465; PMCID: PMC4999868.
    11. Fornes R, Hu M, Maliqueo M, Kokosar M, Benrick A, Carr D, Billig H, Jansson T, Manni L, Stener-Victorin E. Maternal testosterone and placental function: Effect of electroacupuncture on placental expression of angiogenic markers and fetal growth. Mol Cell Endocrinol. 2016 Sep 15; 433:1-11. PMID: 27208621.
      View in: PubMed
    12. Lager S, Ramirez VI, Gaccioli F, Jang B, Jansson T, Powell TL. Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight/obese women. Placenta. 2016 Apr; 40:60-6. PMID: 27016784; PMCID: PMC4809740 [Available on 04/01/17].
    13. Dimasuay KG, Boeuf P, Powell TL, Jansson T. Placental Responses to Changes in the Maternal Environment Determine Fetal Growth. Front Physiol. 2016; 7:12. PMID: 26858656; PMCID: PMC4731498.
    14. Aye IL, Rosario FJ, Powell TL, Jansson T. Reply to Carbillon: Fetal/placental weight ratio and placental function. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):E261. PMID: 26755612; PMCID: PMC4725469.
    15. Capobianco E, Fornes D, Linenberg I, Powell TL, Jansson T, Jawerbaum A. A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth. Mol Cell Endocrinol. 2016 Feb 15; 422:221-32. PMID: 26747729.
      View in: PubMed
    16. Damerill I, Biggar KK, Abu Shehab M, Li SS, Jansson T, Gupta MB. Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition. Mol Endocrinol. 2016 Feb; 30(2):201-16. PMID: 26714229; PMCID: PMC4792228 [Available on 02/01/17].
    17. Malkani N, Biggar K, Shehab MA, Li SS, Jansson T, Gupta MB. Increased IGFBP-1 phosphorylation in response to leucine deprivation is mediated by CK2 and PKC. Mol Cell Endocrinol. 2016 Apr 15; 425:48-60. PMID: 26733150; PMCID: PMC4811673 [Available on 04/15/17].
    18. Rosario FJ, Dimasuay KG, Kanai Y, Powell TL, Jansson T. Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2. Clin Sci (Lond). 2016 Apr 01; 130(7):499-512. PMID: 26608079.
      View in: PubMed
    19. Díaz P, Harris J, Rosario FJ, Powell TL, Jansson T. Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15; 309(12):R1569-77. PMID: 26491104; PMCID: PMC4698418 [Available on 12/15/16].
    20. Rosario FJ, Powell TL, Jansson T. Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 01; 310(1):R87-93. PMID: 26491103; PMCID: PMC4796632 [Available on 01/01/17].
    21. Aye IL, Jansson T, Powell TL. TNF-a stimulates System A amino acid transport in primary human trophoblast cells mediated by p38 MAPK signaling. Physiol Rep. 2015 Oct; 3(10). PMID: 26508738; PMCID: PMC4632960.
    22. Aye IL, Rosario FJ, Powell TL, Jansson T. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12858-63. PMID: 26417088; PMCID: PMC4611638.
    23. Chen YY, Rosario FJ, Shehab MA, Powell TL, Gupta MB, Jansson T. Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR. Clin Sci (Lond). 2015 Dec; 129(12):1131-41. PMID: 26374858; PMCID: PMC4614027.
    24. Pantham P, Rosario FJ, Nijland M, Cheung A, Nathanielsz PW, Powell TL, Galan HL, Li C, Jansson T. Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon. Am J Physiol Regul Integr Comp Physiol. 2015 Oct; 309(7):R740-6. PMID: 26246504; PMCID: PMC4666932 [Available on 10/01/16].
    25. Rosario FJ, Kanai Y, Powell TL, Jansson T. Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth. Obesity (Silver Spring). 2015 Aug; 23(8):1663-70. PMID: 26193061; PMCID: PMC4509489.
    26. Gaccioli F, Aye IL, Roos S, Lager S, Ramirez VI, Kanai Y, Powell TL, Jansson T. Expression and functional characterisation of System L amino acid transporters in the human term placenta. Reprod Biol Endocrinol. 2015 Jun 09; 13:57. PMID: 26050671; PMCID: PMC4462079.
    27. Malkani N, Jansson T, Gupta MB. IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway. Mol Cell Endocrinol. 2015 Sep 05; 412:182-95. PMID: 25957086.
      View in: PubMed
    28. Lager S, Jansson T, Powell TL. Reply to "Letter to the editor: 'fatty acids and placental transport: insight or in vitro artifact?'". Am J Physiol Cell Physiol. 2014 Dec 01; 307(11):C1069. PMID: 25452383; PMCID: PMC4315443.
    29. Lager S, Jansson T, Powell TL. Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids. Am J Physiol Cell Physiol. 2014 Oct 15; 307(8):C738-44. PMID: 25143349; PMCID: PMC4199999.
    30. Acosta O, Ramirez VI, Lager S, Gaccioli F, Dudley DJ, Powell TL, Jansson T. Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers. Am J Obstet Gynecol. 2015 Feb; 212(2):227.e1-7. PMID: 25132463.
      View in: PubMed
    31. Díaz P, Powell TL, Jansson T. The role of placental nutrient sensing in maternal-fetal resource allocation. Biol Reprod. 2014 Oct; 91(4):82. PMID: 25122064; PMCID: PMC4435028.
    32. Aye IL, Lager S, Ramirez VI, Gaccioli F, Dudley DJ, Jansson T, Powell TL. Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways. Biol Reprod. 2014 Jun; 90(6):129. PMID: 24759787; PMCID: PMC4094003.
    33. Aye IL, Gao X, Weintraub ST, Jansson T, Powell TL. Adiponectin inhibits insulin function in primary trophoblasts by PPARa-mediated ceramide synthesis. Mol Endocrinol. 2014 Apr; 28(4):512-24. PMID: 24606127; PMCID: PMC3968401.
    34. Lager S, Samulesson AM, Taylor PD, Poston L, Powell TL, Jansson T. Diet-induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling. Physiol Rep. 2014 Feb 01; 2(2):e00242. PMID: 24744907; PMCID: PMC3966251.
    35. Abu Shehab M, Damerill I, Shen T, Rosario FJ, Nijland M, Nathanielsz PW, Kamat A, Jansson T, Gupta MB. Liver mTOR controls IGF-I bioavailability by regulation of protein kinase CK2 and IGFBP-1 phosphorylation in fetal growth restriction. Endocrinology. 2014 Apr; 155(4):1327-39. PMID: 24437487; PMCID: PMC3959599.
    36. Kavitha JV, Rosario FJ, Nijland MJ, McDonald TJ, Wu G, Kanai Y, Powell TL, Nathanielsz PW, Jansson T. Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon. FASEB J. 2014 Mar; 28(3):1294-305. PMID: 24334703; PMCID: PMC3929672.
    37. Gaccioli F, White V, Capobianco E, Powell TL, Jawerbaum A, Jansson T. Maternal overweight induced by a diet with high content of saturated fat activates placental mTOR and eIF2alpha signaling and increases fetal growth in rats. Biol Reprod. 2013 Oct; 89(4):96. PMID: 24006279.
      View in: PubMed
    38. Cox LA, Li C, Glenn JP, Lange K, Spradling KD, Nathanielsz PW, Jansson T. Expression of the placental transcriptome in maternal nutrient reduction in baboons is dependent on fetal sex. J Nutr. 2013 Nov; 143(11):1698-708. PMID: 24047701; PMCID: PMC3796342.
    39. Jansson T, Powell TL. Role of placental nutrient sensing in developmental programming. Clin Obstet Gynecol. 2013 Sep; 56(3):591-601. PMID: 23703224; PMCID: PMC3732521.
    40. Aye IL, Jansson T, Powell TL. Interleukin-1ß inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts. Mol Cell Endocrinol. 2013 Dec 05; 381(1-2):46-55. PMID: 23891856; PMCID: PMC3795822.
    41. Li C, Shu ZJ, Lee S, Gupta MB, Jansson T, Nathanielsz PW, Kamat A. Effects of maternal nutrient restriction, intrauterine growth restriction, and glucocorticoid exposure on phosphoenolpyruvate carboxykinase-1 expression in fetal baboon hepatocytes in vitro. J Med Primatol. 2013 Aug; 42(4):211-9. PMID: 23600855; PMCID: PMC3979338.
    42. Lager S, Gaccioli F, Ramirez VI, Jones HN, Jansson T, Powell TL. Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4. J Lipid Res. 2013 Mar; 54(3):725-33. PMID: 23275648; PMCID: PMC3617946.
    43. Rosario FJ, Kanai Y, Powell TL, Jansson T. Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells. J Physiol. 2013 Feb 01; 591(3):609-25. PMID: 23165769; PMCID: PMC3577540.
    44. Jansson N, Rosario FJ, Gaccioli F, Lager S, Jones HN, Roos S, Jansson T, Powell TL. Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies. J Clin Endocrinol Metab. 2013 Jan; 98(1):105-13. PMID: 23150676; PMCID: PMC3537112.
    45. McDonald TJ, Wu G, Nijland MJ, Jenkins SL, Nathanielsz PW, Jansson T. Effect of 30% nutrient restriction in the first half of gestation on maternal and fetal baboon serum amino acid concentrations. Br J Nutr. 2013 Apr 28; 109(8):1382-8. PMID: 23046718; PMCID: PMC4018804.
    46. Sun M, Maliqueo M, Benrick A, Johansson J, Shao R, Hou L, Jansson T, Wu X, Stener-Victorin E. Maternal androgen excess reduces placental and fetal weights, increases placental steroidogenesis, and leads to long-term health effects in their female offspring. Am J Physiol Endocrinol Metab. 2012 Dec 01; 303(11):E1373-85. PMID: 23047983.
      View in: PubMed
    47. Rosario FJ, Schumacher MA, Jiang J, Kanai Y, Powell TL, Jansson T. Chronic maternal infusion of full-length adiponectin in pregnant mice down-regulates placental amino acid transporter activity and expression and decreases fetal growth. J Physiol. 2012 Mar 15; 590(6):1495-509. PMID: 22289908; PMCID: PMC3382336.
    48. Carter MF, Powell TL, Li C, Myatt L, Dudley D, Nathanielsz P, Jansson T. Fetal serum folate concentrations and placental folate transport in obese women. Am J Obstet Gynecol. 2011 Jul; 205(1):83.e17-25. PMID: 21514551; PMCID: PMC3145010.
    49. Rosario FJ, Jansson N, Kanai Y, Prasad PD, Powell TL, Jansson T. Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters. Endocrinology. 2011 Mar; 152(3):1119-29. PMID: 21285325; PMCID: PMC3858644.
    50. Jones HN, Jansson T, Powell TL. Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells. Diabetes. 2010 May; 59(5):1161-70. PMID: 20150288; PMCID: PMC2857896.
    51. Jansson T, Myatt L, Powell TL. The role of trophoblast nutrient and ion transporters in the development of pregnancy complications and adult disease. Curr Vasc Pharmacol. 2009 Oct; 7(4):521-33. PMID: 19485888.
      View in: PubMed
    52. Jansson T. Novel mechanism causing restricted fetal growth: does maternal homocysteine impair placental amino acid transport? J Physiol. 2009 Sep 01; 587(Pt 17):4123. PMID: 19720845; PMCID: PMC2754343.
    53. Roos S, Powell TL, Jansson T. Placental mTOR links maternal nutrient availability to fetal growth. Biochem Soc Trans. 2009 Feb; 37(Pt 1):295-8. PMID: 19143650.
      View in: PubMed
    54. Jones HN, Woollett LA, Barbour N, Prasad PD, Powell TL, Jansson T. High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J. 2009 Jan; 23(1):271-8. PMID: 18827021; PMCID: PMC2626621.
    55. Jansson N, Nilsfelt A, Gellerstedt M, Wennergren M, Rossander-Hulthén L, Powell TL, Jansson T. Maternal hormones linking maternal body mass index and dietary intake to birth weight. Am J Clin Nutr. 2008 Jun; 87(6):1743-9. PMID: 18541564.
      View in: PubMed
    56. Jansson T, Powell TL. Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin Sci (Lond). 2007 Jul; 113(1):1-13. PMID: 17536998.
      View in: PubMed
    57. Roos S, Jansson N, Palmberg I, Säljö K, Powell TL, Jansson T. Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. J Physiol. 2007 Jul 01; 582(Pt 1):449-59. PMID: 17463046; PMCID: PMC2075295.
    58. Ericsson A, Säljö K, Sjöstrand E, Jansson N, Prasad PD, Powell TL, Jansson T. Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport. J Physiol. 2007 Jun 15; 581(Pt 3):1323-32. PMID: 17430988; PMCID: PMC2170823.
    59. Magnusson-Olsson AL, Lager S, Jacobsson B, Jansson T, Powell TL. Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E24-30. PMID: 17299085.
      View in: PubMed
    60. Hultman K, Alexanderson C, Mannerås L, Sandberg M, Holmäng A, Jansson T. Maternal taurine supplementation in the late pregnant rat stimulates postnatal growth and induces obesity and insulin resistance in adult offspring. J Physiol. 2007 Mar 15; 579(Pt 3):823-33. PMID: 17204495; PMCID: PMC2151367.
    61. Jansson N, Pettersson J, Haafiz A, Ericsson A, Palmberg I, Tranberg M, Ganapathy V, Powell TL, Jansson T. Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet. J Physiol. 2006 Nov 01; 576(Pt 3):935-46. PMID: 16916910; PMCID: PMC1892642.
    62. Dahlgren J, Samuelsson AM, Jansson T, Holmäng A. Interleukin-6 in the maternal circulation reaches the rat fetus in mid-gestation. Pediatr Res. 2006 Aug; 60(2):147-51. PMID: 16864694.
      View in: PubMed
    63. Settle P, Sibley CP, Doughty IM, Johnston T, Glazier JD, Powell TL, Jansson T, D'Souza SW. Placental lactate transporter activity and expression in intrauterine growth restriction. J Soc Gynecol Investig. 2006 Jul; 13(5):357-63. PMID: 16814165.
      View in: PubMed
    64. Sibley CP, Turner MA, Cetin I, Ayuk P, Boyd CA, D'Souza SW, Glazier JD, Greenwood SL, Jansson T, Powell T. Placental phenotypes of intrauterine growth. Pediatr Res. 2005 Nov; 58(5):827-32. PMID: 16183820.
      View in: PubMed
    65. Ericsson A, Hamark B, Jansson N, Johansson BR, Powell TL, Jansson T. Hormonal regulation of glucose and system A amino acid transport in first trimester placental villous fragments. Am J Physiol Regul Integr Comp Physiol. 2005 Mar; 288(3):R656-62. PMID: 15539610.
      View in: PubMed
    66. Jansson T, Wennergren M, Powell T. [Pregnancy complications can impair placental transport systems. Aberrant fetal growth, for example in diabetes, is only now beginning to be understood]. Lakartidningen. 2003 Aug 07; 100(32-33):2508-11. PMID: 12959009.
      View in: PubMed
    67. Jansson T, Ekstrand Y, Björn C, Wennergren M, Powell TL. Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetes. Diabetes. 2002 Jul; 51(7):2214-9. PMID: 12086952.
      View in: PubMed
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