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Angelo D'Alessandro

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

    Collapse Biography 
    Collapse awards and honors
    2017Guest Editor - Special Issue: Red Cell storage and Integrated omics, Blood Transfusion
    2016Research Grant, Linda Crnic Institute for Down Syndrome
    2016Early Career Grant, National Blood Foundation
    2015Scott Murphy Lectureship, BEST 2015
    2013Guest Editor - Special Issue: Integrated Omics, Journal of Proteomics
    2013PhD Thesis publication, Italian National Blood Centre
    2008BEST - Top 50 Italian Academic Graduates, Alma Mater Studiorum Bologne - Presidency of the Italian Republic

    Collapse Research 
    Collapse research activities and funding
    R01DK136945     (TENNESSEN, JASON MICHAEL)Aug 1, 2023 - May 31, 2028
    NIH
    Investigating metabolic responses to high sugar diets and the onset of diabetic phenotypes
    Role: Co-Principal Investigator
    R01HL161004     (IRWIN, DAVID CHARLES)Feb 1, 2022 - Jan 31, 2026
    NIH
    The paradoxical response to iron in pulmonary hypertension of sickle cell disease
    Role: Co-Principal Investigator
    R01HL149714     (D'ALESSANDRO, ANGELO)Mar 15, 2020 - Feb 28, 2025
    NIH
    Interactions between the ADORA2b/Sphk1axis and the AE1-Hb switch in red blood cell aging in vivo and in vitro
    Role: Principal Investigator
    R21HL150032     (D'ALESSANDRO, ANGELO)Mar 5, 2020 - Feb 28, 2022
    NIH
    MIRAGES: Metabolic Investigation of Red blood cells as a function of Aging, Genetics, Environment, and Storage
    Role: Principal Investigator
    R01HL148151     (D'ALESSANDRO, ANGELO ;KARAFIN, MATTHEW S;SPITALNIK, STEVEN L ;ZIMRING, JAMES C.)Sep 25, 2019 - Aug 31, 2023
    NIH
    The Impact of Oxidative Stress on Erythocyte Biology
    Role: Co-Principal Investigator
    R01HL146442     (D'ALESSANDRO, ANGELO)Aug 1, 2019 - Apr 30, 2028
    NIH
    The role of ferroptosis in red cell aging in vivo and in vitro
    Role: Principal Investigator
    RM1GM131968     (SILLIMAN, CHRISTOPHER C.)May 20, 2019 - Apr 30, 2025
    NIH
    Resuscitation Strategies for Achieving Thrombo-inflammatory Homeostasis
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nemkov T, Stephenson D, Earley EJ, Keele GR, Hay A, Key A, Haiman Z, Erickson C, Dzieciatkowska M, Reisz JA, Moore A, Stone M, Deng X, Kleinman S, Spitalnik SL, Hod EA, Hudson KE, Hansen KC, Palsson BO, Churchill GA, Roubinian N, Norris PJ, Busch MP, Zimring JC, Page GP, D'Alessandro A. Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes. bioRxiv. 2024 Jun 11. PMID: 38260479.
      View in: PubMed
    2. Anastasiadi AT, Arvaniti VZ, Hudson KE, Kriebardis AG, Stathopoulos C, D'Alessandro A, Spitalnik SL, Tzounakas VL. Exploring unconventional attributes of red blood cells and their potential applications in biomedicine. Protein Cell. 2024 May 07; 15(5):315-330. PMID: 38270470.
      View in: PubMed
    3. He F, Laranjeira AB, Kong T, Lin S, Ashworth KJ, Liu A, Lasky NM, Fisher DA, Cox MJ, Fulbright MC, Antunes-Heck L, Yu L, Brakhane M, Gao B, Sykes SM, D'Alessandro A, Di Paola J, Oh ST. Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms. J Clin Invest. 2024 Feb 01; 134(3). PMID: 38060311.
      View in: PubMed
    4. Nemkov T, Stephenson D, Erickson C, Dzieciatkowska M, Key A, Moore A, Earley EJ, Page GP, Lacroix IS, Stone M, Deng X, Raife T, Kleinman S, Zimring JC, Roubinian N, Hansen KC, Busch MP, Norris PJ, D'Alessandro A. Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in?vitro and in?vivo. Blood. 2024 02 01; 143(5):456-472. PMID: 37976448.
      View in: PubMed
    5. Murray KO, Maurer GS, Gioscia-Ryan RA, Zigler MC, Ludwig KR, D'Alessandro A, Reisz JA, Rossman MJ, Seals DR, Clayton ZS. The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice. Geroscience. 2024 06; 46(3):3311-3324. PMID: 38265578.
      View in: PubMed
    6. Fleck SA, Biswas P, DeWitt ED, Knuteson RL, Eisman RC, Nemkov T, D'Alessandro A, Tennessen JM, Rideout E, Weaver LN. Auxin exposure disrupts feeding behavior and fatty acid metabolism in adult Drosophila. Elife. 2024 Jan 19; 12. PMID: 38240746.
      View in: PubMed
    7. Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. Publisher Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2024 Jan; 5(1):210. PMID: 38200246.
      View in: PubMed
    8. Heidarian Y, Tourigny JP, Fasteen TD, Mahmoudzadeh NH, Hurlburt AJ, Nemkov T, Reisz JA, D'Alessandro A, Tennessen JM. Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase. G3 (Bethesda). 2023 12 29; 14(1). PMID: 37792629.
      View in: PubMed
    9. D'Alessandro A, Earley EJ, Nemkov T, Stephenson D, Dzieciatkowska M, Hansen KC, Minetti G, Champigneulle B, Stauffer E, Pichon A, Furian M, Verges S, Kleinman S, Norris PJ, Busch MP, Page GP, Kaestner L. Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2,3-bisphosphoglycerate in humans at high altitude. Proc Natl Acad Sci U S A. 2024 Jan 02; 121(1):e2315930120. PMID: 38147558.
      View in: PubMed
    10. Swift LM, Roberts A, Pressman J, Guerrelli D, Allen S, Haq KT, Reisz JA, D'Alessandro A, Posnack NG. Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexyl phthalate. Toxicol Sci. 2023 12 21; 197(1):79-94. PMID: 37812252.
      View in: PubMed
    11. Santoro N, Kuhn K, Pretzel S, Schauer IE, Fought A, D'Alessandro A, Stephenson D, Bradford AP. A high-fat eucaloric diet induces reprometabolic syndrome of obesity in normal weight women. PNAS Nexus. 2024 Jan; 3(1):pgad440. PMID: 38178979.
      View in: PubMed
    12. Schaid TR, Mitra S, Stafford P, DeBot M, Thielen O, Hallas W, Cralley A, Gallagher L, Jeffrey D, Hansen KC, D'Alessandro A, Silliman CC, Dabertrand F, Cohen MJ. Endothelial Cell Calcium Influx Mediates Trauma-induced Endothelial Permeability. Ann Surg. 2023 Dec 11. PMID: 38073572.
      View in: PubMed
    13. Shea SM, Reisz JA, Mihalko EP, Rahn KC, Rassam RMG, Chitrakar A, Gamboni F, D'Alessandro A, Spinella PC, Thomas KA. Cold-stored platelet hemostatic capacity is maintained for three weeks of storage and associated with taurine metabolism. J Thromb Haemost. 2024 Apr; 22(4):1154-1166. PMID: 38072374.
      View in: PubMed
    14. Fleck SA, Biswas P, DeWitt ED, Knuteson RL, Eisman RC, Nemkov T, D'Alessandro A, Tennessen JM, Rideout EJ, Weaver LN. Auxin Exposure Disrupts Feeding Behavior and Fatty Acid Metabolism in Adult Drosophila. bioRxiv. 2023 Dec 04. PMID: 37645868.
      View in: PubMed
    15. Cui J, Christin JR, Reisz JA, Cendali FI, Sanawar R, Coutinho De Miranda M, D'Alessandro A, Guo W. Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance. Sci Adv. 2023 12; 9(48):eadh1891. PMID: 38039374.
      View in: PubMed
    16. D'Alessandro A, Nouraie SM, Zhang Y, Cendali F, Gamboni F, Reisz JA, Zhang X, Bartsch KW, Galbraith MD, Espinosa JM, Gordeuk VR, Gladwin MT. Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment. Haematologica. 2023 12 01; 108(12):3418-3432. PMID: 37439373.
      View in: PubMed
    17. Bassett S, Ding Y, Roy MK, Reisz JA, D'Alessandro A, Nagpal P, Chatterjee A. Light-Driven Metabolic Pathways in Non-Photosynthetic Biohybrid Bacteria. Chembiochem. 2024 01 15; 25(2):e202300572. PMID: 37861981.
      View in: PubMed
    18. Leone MA, Gelati M, Profico DC, Gobbi C, Pravat? E, Copetti M, Conti C, Abate L, Amoruso L, Apollo F, Balzano RF, Bicchi I, Carella M, Ciampini A, Colosimo C, Crociani P, D'Aloisio G, Di Viesti P, Ferrari D, Fogli D, Fontana A, Frondizi D, Grespi V, Kuhle J, Laborante A, Lombardi I, Muzi G, Paci F, Placentino G, Popolizio T, Ricciolini C, Sabatini S, Silveri G, Spera C, Stephenson D, Stipa G, Tinella E, Zarrelli M, Zecca C, Ventura Y, D'Alessandro A, Peruzzotti-Jametti L, Pluchino S, Vescovi AL. Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis. Cell Stem Cell. 2023 12 07; 30(12):1597-1609.e8. PMID: 38016468.
      View in: PubMed
    19. Key A, Haiman Z, Palsson BO, D'Alessandro A. Modeling Red Blood Cell Metabolism in the Omics Era. Metabolites. 2023 Nov 11; 13(11). PMID: 37999241.
      View in: PubMed
    20. Remigante A, Straface E, D'Alessandro A, Morabito R. Editorial: Erythrocytes as a target of oxidative stress in blood. Front Physiol. 2023; 14:1310053. PMID: 38028757.
      View in: PubMed
    21. Diaz AV, Stephenson D, Nemkov T, D'Alessandro A, Reis T. Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells. Genetics. 2023 11 01; 225(3). PMID: 37738330.
      View in: PubMed
    22. Kim CY, Larsen HJ, Spitalnik SL, Hod EA, Francis RO, Hudson KE, Gordy DE, Stone EF, Peltier S, Amireault P, D'Alessandro A, Zimring JC, Buehler PW, Fu X, Thomas T. Low-Dose Dietary Fish Oil Improves RBC Deformability without Improving Post-Transfusion Recovery in Mice. Nutrients. 2023 Oct 20; 15(20). PMID: 37892532.
      View in: PubMed
    23. Trujillo MN, Jennings EQ, Hoffman EA, Zhang H, Phoebe AM, Mastin GE, Kitamura N, Reisz JA, Megill E, Kantner D, Marcinkiewicz MM, Twardy SM, Lebario F, Chapman E, McCullough RL, D'Alessandro A, Snyder NW, Cusanovich DA, Galligan JJ. Lactoylglutathione promotes inflammatory signaling in macrophages. bioRxiv. 2023 Oct 10. PMID: 37873172.
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    24. Cantoni E, Merelli I, Stefanoni D, Tomelleri A, Campochiaro C, Giordano V, Panigada M, Baldissera EM, Merlo Pich L, Natoli V, Ziogas A, Dom?nguez-Andr?s J, De Luca G, Mazza D, Zambrano S, Gnani D, Ferrarini M, Ferrero E, Agresti A, Vergani B, Leone BE, Cenci S, Ravelli A, Matucci-Cerinic M, D'Alessandro A, Joosten LAB, Dagna L, Netea MG, Molteni R, Cavalli G. Myelomonocytic cells in giant cell arteritis activate trained immunity programs sustaining inflammation and cytokine production. Rheumatology (Oxford). 2023 10 03; 62(10):3469-3479. PMID: 36802235.
      View in: PubMed
    25. Thomas TA, Qiu A, Kim CY, Gordy DE, Miller A, Tredicine M, Dzieciatkowska M, Dei Zotti F, Hod EA, D'Alessandro A, Zimring JC, Spitalnik SL, Hudson KE. Reticulocytes in donor blood units enhance red blood cell alloimmunization. Haematologica. 2023 10 01; 108(10):2639-2651. PMID: 37078267.
      View in: PubMed
    26. Monte AA, Vest A, Reisz JA, Berninzoni D, Hart C, Dylla L, D'Alessandro A, Heard KJ, Wood C, Pattee J. Correction to: A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation. J Med Toxicol. 2023 Oct; 19(4):416. PMID: 37365428.
      View in: PubMed
    27. Correnti S, Preian? M, Fregola A, Gamboni F, Stephenson D, Savino R, D'Alessandro A, Terracciano R. Seminal plasma untargeted metabolomic and lipidomic profiling for the identification of a novel panel of biomarkers and therapeutic targets related to male infertility. Front Pharmacol. 2023; 14:1275832. PMID: 37829298.
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    28. Thielen O, Mitra S, Debot M, Schaid T, Hallas W, Gallagher LT, Erickson C, Cralley A, Stafford P, Silliman C, D'Alessandro A, Hansen K, Sauaia A, Moore E, Mosnier L, Griffin J, Cohen M. Mitigation of trauma-induced endotheliopathy by activated protein C: A potential therapeutic for postinjury thromboinflammation. J Trauma Acute Care Surg. 2024 01 01; 96(1):116-122. PMID: 37733304.
      View in: PubMed
    29. Monsorno K, Ginggen K, Ivanov A, Buckinx A, Lalive AL, Tchenio A, Benson S, Vendrell M, D'Alessandro A, Beule D, Pellerin L, Mameli M, Paolicelli RC. Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice. Nat Commun. 2023 09 16; 14(1):5749. PMID: 37717033.
      View in: PubMed
    30. Swift LM, Roberts A, Pressman J, Guerrelli D, Allen S, Haq KT, Reisz JA, D'Alessandro A, Posnack NG. Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexylphthalate (DEHP). bioRxiv. 2023 Sep 13. PMID: 37293060.
      View in: PubMed
    31. Craighead DH, Freeberg KA, Heinbockel TC, Rossman MJ, Jackman RA, McCarty NP, Jankowski LR, Nemkov T, Reisz JA, D'Alessandro A, Chonchol M, Bailey EF, Seals DR. Time-Efficient, High-Resistance Inspiratory Muscle Strength Training Increases Exercise Tolerance in Midlife and Older Adults. Med Sci Sports Exerc. 2024 Feb 01; 56(2):266-276. PMID: 37707508.
      View in: PubMed
    32. Cohen MJ, Erickson CB, Lacroix IS, Debot M, Dzieciatkowska M, Schaid TR, Hallas MW, Thielen ON, Cralley AL, Banerjee A, Moore EE, Silliman CC, D'Alessandro A, Hansen KC. Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patients. bioRxiv. 2023 Sep 09. PMID: 37645811.
      View in: PubMed
    33. Schaid TR, LaCroix I, Cohen MJ, Hansen KC, Moore EE, Sauaia A, Cralley AL, Thielen O, Hallas W, Erickson C, Mitra S, Dzieciatkowska M, Silliman CC, D'Alessandro A. METABOLOMIC AND PROTEOMIC CHANGES IN TRAUMA-INDUCED HYPOCALCEMIA. Shock. 2023 11 01; 60(5):652-663. PMID: 37695733.
      View in: PubMed
    34. Lee JY, Stevens RP, Pastukh VV, Pastukh VM, Kozhukhar N, Alexeyev MF, Reisz JA, Nerguizian D, D'Alessandro A, Koloteva A, Gwin MS, Roberts JT, Borchert GM, Wagener BM, Pittet JF, Graham BB, Stenmark KR, Stevens T. PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells. Am J Respir Cell Mol Biol. 2023 09; 69(3):340-354. PMID: 37201952.
      View in: PubMed
    35. O'Brien C, Ling T, Berman JM, Culp-Hill R, Reisz JA, Rondeau V, Jahangiri S, St-Germain J, Macwan V, Astori A, Zeng A, Hong JY, Li M, Yang M, Jana S, Gamboni F, Tsao E, Liu W, Dick JE, Lin H, Melnick A, Tikhonova A, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL. Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid ?-oxidation and inducing lipotoxicity. Haematologica. 2023 09 01; 108(9):2343-2357. PMID: 37021547.
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    36. Reisz JA, Dzieciatkowska M, Stephenson D, Gamboni F, Morton DH, D'Alessandro A. Red Blood Cells from Individuals with Lesch-Nyhan Syndrome: Multi-Omics Insights into a Novel S162N Mutation Causing Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency. Antioxidants (Basel). 2023 Aug 31; 12(9). PMID: 37760001.
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    37. Roy MK, Wilkerson RB, Alexander K, Nokoff NJ, Cree-Green M, D'Alessandro A. Longitudinal metabolic study of red blood cells from patients undergoing gender-affirming testosterone therapy. Blood Adv. 2023 08 22; 7(16):4269-4277. PMID: 36001490.
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    38. Lisk C, Cendali F, Setua S, Thangaraju K, Pak DI, Swindle D, Dzieciatkowska M, Gamboni F, Hassell K, Nuss R, George G, Davizon-Castillo P, Buehler PW, D'Alessandro A, Irwin DC. Metabolic and Proteomic Divergence Is Present in Circulating Monocytes and Tissue-Resident Macrophages from Berkeley Sickle Cell Anemia and ?-Thalassemia Mice. J Proteome Res. 2023 09 01; 22(9):2925-2935. PMID: 37606205.
      View in: PubMed
    39. Ohm AM, Affandi T, Reisz JA, Caino MC, D'Alessandro A, Reyland ME. Metabolic reprogramming contributes to radioprotection by protein kinase Cd. J Biol Chem. 2023 10; 299(10):105186. PMID: 37611829.
      View in: PubMed
    40. Gadwa J, Amann M, Bickett TE, Knitz MW, Darragh LB, Piper M, Van Court B, Bukkapatnam S, Pham TT, Wang XJ, Saviola AJ, Deak LC, Uma?a P, Klein C, D'Alessandro A, Karam SD. Selective targeting of IL2R?? combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC. Cell Rep Med. 2023 08 15; 4(8):101150. PMID: 37586327.
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    41. Chen C, Xie T, Zhang Y, Wang Y, Yu F, Lin L, Zhang W, Brown BC, Zhang X, Kellems RE, D'Alessandro A, Xia Y. Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model. J Am Soc Nephrol. 2023 10 01; 34(10):1647-1671. PMID: 37725437.
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    42. D'Alessandro A, Hod EA. Red Blood Cell Storage: From Genome to Exposome Towards Personalized Transfusion Medicine. Transfus Med Rev. 2023 10; 37(4):150750. PMID: 37574398.
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    43. Cralley AL, Erickson C, Schaid TR, Hallas W, Thielen O, Mitra S, Stafford P, Hom P, Silliman C, Cohen MJ, Moore EE, D'Alessandro A, Hansen KC. The proteomic and metabolomic signatures of isolated and polytrauma traumatic brain injury. Am J Surg. 2023 12; 226(6):790-797. PMID: 37541795.
      View in: PubMed
    44. Isiksacan Z, D'Alessandro A, Wolf SM, McKenna DH, Tessier SN, Kucukal E, Gokaltun AA, William N, Sandlin RD, Bischof J, Mohandas N, Busch MP, Elbuken C, Gurkan UA, Toner M, Acker JP, Yarmush ML, Usta OB. Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine. Proc Natl Acad Sci U S A. 2023 08 08; 120(32):e2115616120. PMID: 37494421.
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    45. LaCroix IS, Cohen M, Moore EE, Dzieciatkowska M, Silliman CC, Hansen KC, D'Alessandro A. Omics markers of platelet transfusion in trauma patients. Transfusion. 2023 08; 63(8):1447-1462. PMID: 37466356.
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    46. Lisk C, Cendali F, Pak DI, Swindle D, Hassell K, Nuss R, George G, Davizon-Castillo P, Buehler PW, D'Alessandro A, Irwin DC. Moderate hypoxia induces metabolic divergence in circulating monocytes and tissue resident macrophages from Berkeley sickle cell anemia mice. Front Med (Lausanne). 2023; 10:1149005. PMID: 37502360.
      View in: PubMed
    47. Coleman JR, D'Alessandro A, LaCroix I, Dzieciatkowska M, Lutz P, Mitra S, Gamboni F, Ruf W, Silliman CC, Cohen MJ. A metabolomic and proteomic analysis of pathologic hypercoagulability in traumatic brain injury patients after dura violation. J Trauma Acute Care Surg. 2023 12 01; 95(6):925-934. PMID: 37405823.
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    48. D'Alessandro A, Anastasiadi AT, Tzounakas VL, Nemkov T, Reisz JA, Kriebardis AG, Zimring JC, Spitalnik SL, Busch MP. Red Blood Cell Metabolism In Vivo and In Vitro. Metabolites. 2023 Jun 27; 13(7). PMID: 37512500.
      View in: PubMed
    49. Walters K, Sajek MP, Murphy E, Issaian A, Baldwin A, Harrison E, Daniels M, Reisz JA, Hansen K, D'Alessandro A, Mukherjee N. Small-molecule Ro-08-2750 interacts with many RNA-binding proteins and elicits MUSASHI2-independent phenotypes. RNA. 2023 10; 29(10):1458-1470. PMID: 37369529.
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    50. Dziewulska KH, Reisz JA, Hay AM, D'Alessandro A, Zimring JC. Hemolysis and Metabolic Lesion of G6PD Deficient RBCs in Response to Dapsone Hydroxylamine in a Humanized Mouse Model. J Pharmacol Exp Ther. 2023 09; 386(3):323-330. PMID: 37348965.
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    51. Heidarian Y, Tourigny JP, Fasteen TD, Mahmoudzadeh NH, Hurlburt AJ, Nemkov T, Reisz JA, D'Alessandro A, Tennessen JM. Metabolomic analysis of Drosophila melanogaster larvae lacking Pyruvate kinase. bioRxiv. 2023 Jun 19. PMID: 37333180.
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    52. LaCroix IS, Cralley A, Moore EE, Cendali FI, Dzieciatkowska M, Hom P, Mitra S, Cohen M, Silliman C, Sauaia A, Hansen KC, D'Alessandro A. Omics Signatures of Tissue Injury and Hemorrhagic Shock in Swine. Ann Surg. 2023 12 01; 278(6):e1299-e1312. PMID: 37334680.
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    53. Kawakami H, Chen KQ, Zhang R, Pappas MP, Bailey A, Reisz JA, Corcoran D, Nishinakamura R, D'Alessandro A, Kawakami Y. Sall4 restricts glycolytic metabolism in limb buds through transcriptional regulation of glycolytic enzyme genes. Dev Biol. 2023 09; 501:28-38. PMID: 37301463.
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    54. Turner JA, Fredrickson MA, D'Antonio M, Katsnelson E, MacBeth M, Van Gulick R, Chimed TS, McCarter M, D'Alessandro A, Robinson WA, Couts KL, Pelanda R, Klarquist J, Tobin RP, Torres RM. Lysophosphatidic acid modulates CD8 T cell immunosurveillance and metabolism to impair anti-tumor immunity. Nat Commun. 2023 06 03; 14(1):3214. PMID: 37270644.
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    55. Skinner SC, Nemkov T, Diaw M, Mbaye MN, Diedhiou D, Sow D, Gueye F, Lopez P, Connes P, D'Alessandro A. Metabolic Profile of Individuals with and without Type 2 Diabetes from Sub-Saharan Africa. J Proteome Res. 2023 07 07; 22(7):2319-2326. PMID: 37264938.
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    56. Monte AA, Vest A, Reisz JA, Berninzoni D, Hart C, Dylla L, D'Alessandro A, Heard KJ, Wood C, Pattee J. A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation. J Med Toxicol. 2023 07; 19(3):255-261. PMID: 37231244.
      View in: PubMed
    57. D'Alessandro A, Bugert P. Omics and Machine Learning in Transfusion Medicine. Transfus Med Hemother. 2023 Jun; 50(3):161-162. PMID: 37408646.
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    58. Elias AD, Spoelstra NS, Staley AW, Sams S, Crump LS, Vidal GA, Borges VF, Kabos P, Diamond JR, Shagisultanova E, Afghahi A, Mayordomo J, McSpadden T, Crawford G, D'Alessandro A, Zolman KL, van Bokhoven A, Zhuang Y, Gallagher RI, Wulfkuhle JD, Petricoin Iii EF, Gao D, Richer JK. Phase II trial of fulvestrant plus enzalutamide in ER+/HER2- advanced breast cancer. NPJ Breast Cancer. 2023 May 20; 9(1):41. PMID: 37210417.
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    59. Bolf EL, Beadnell TC, Rose MM, D'Alessandro A, Nemkov T, Hansen KC, Schweppe RE. Dasatinib and Trametinib Promote Anti-Tumor Metabolic Activity. Cells. 2023 05 12; 12(10). PMID: 37408209.
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    60. D'Alessandro A, Lukens JR, Zimring JC. The role of PIMT in Alzheimer's disease pathogenesis: A novel hypothesis. Alzheimers Dement. 2023 11; 19(11):5296-5302. PMID: 37157118.
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    61. Nemkov T, Cendali F, Stefanoni D, Martinez JL, Hansen KC, San-Mill?n I, D'Alessandro A. Metabolic Signatures of Performance in Elite World Tour Professional Male Cyclists. Sports Med. 2023 08; 53(8):1651-1665. PMID: 37148487.
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    62. Guerrelli D, Desai M, Semaan Y, Essa Y, Zurakowski D, Cendali FI, Reisz JA, D'Alessandro A, Luban NC, Posnack NG. Prevalence and Clinical Implications of Heightened Plastic Chemical Exposure in Pediatric Patients Undergoing Cardiopulmonary Bypass. medRxiv. 2023 May 02. PMID: 37205364.
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    63. Piper M, Hoen M, Darragh LB, Knitz MW, Nguyen D, Gadwa J, Durini G, Karakoc I, Grier A, Neupert B, Van Court B, Abdelazeem KNM, Yu J, Olimpo NA, Corbo S, Ross RB, Pham TT, Joshi M, Kedl RM, Saviola AJ, Amann M, Uma?a P, Codarri Deak L, Klein C, D'Alessandro A, Karam SD. Simultaneous targeting of PD-1 and IL-2R?? with radiation therapy inhibits pancreatic cancer growth and metastasis. Cancer Cell. 2023 05 08; 41(5):950-969.e6. PMID: 37116489.
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    64. Hay A, Nemkov T, Gamboni F, Dzieciatkowska M, Key A, Galbraith M, Bartsch K, Sun K, Xia Y, Stone M, Busch MP, Norris PJ, Zimring JC, D'Alessandro A. Sphingosine 1-phosphate has a negative effect on RBC storage quality. Blood Adv. 2023 04 25; 7(8):1379-1393. PMID: 36469038.
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    65. Davis SM, Urban R, D'Alessandro A, Reisz JA, Chan CL, Kelsey M, Howell S, Tartaglia N, Zeitler P, Baker Ii P. Unique plasma metabolite signature for adolescents with Klinefelter syndrome reveals altered fatty acid metabolism. Endocr Connect. 2023 May 01; 12(5). PMID: 36884262.
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    66. D'Alessandro A, Nouraie SM, Zhang Y, Cendali F, Gamboni F, Reisz JA, Zhang X, Bartsch KW, Galbraith MD, Gordeuk VR, Gladwin MT. In vivo evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunction. Am J Hematol. 2023 07; 98(7):1017-1028. PMID: 36971592.
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    67. Custer B, Bloch EM, Bryant BJ, D'Alessandro A, Delaney M, Goel R, Hod EA, Josephson CD, Katz LM, Miller YM, Sayers MH, Seheult JN, Triulzi DJ, Berger J, Zou S, Hailu B, Glynn SA, Roubinian NH. Proceedings of the 2022 NHLBI and OASH state of the science in transfusion medicine symposium. Transfusion. 2023 05; 63(5):1074-1091. PMID: 37005871.
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    68. Esparza O, Hernandez G, Rojas-Sanchez G, Calzada-Martinez J, Nemkov T, Kelher M, Kelly K, Silliman CC, DomBourian M, Dumont LJ, D'Alessandro A, Davizon-Castillo P. Platelets from blood diversion pouches (DPs) are a suitable alternative for functional, bioenergetic, and metabolomic analyses. Blood Transfus. 2023 Mar 31. PMID: 37235734.
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    69. Unali G, Crivicich G, Pagani I, Abou-Alezz M, Folchini F, Valeri E, Matafora V, Reisz JA, Giordano AMS, Cuccovillo I, Butta GM, Donnici L, D'Alessandro A, De Francesco R, Manganaro L, Cittaro D, Merelli I, Petrillo C, Bachi A, Vicenzi E, Kajaste-Rudnitski A. Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity. EMBO J. 2023 05 15; 42(10):e112234. PMID: 36970857.
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    70. Culp-Hill R, Stevens BM, Jones CL, Pei S, Dzieciatkowska M, Minhajuddin M, Jordan CT, D'Alessandro A. Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2. Metabolites. 2023 Mar 24; 13(4). PMID: 37110126.
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    71. Kumar S, Vassallo JD, Nattamai KJ, Hassan A, Karns R, Vollmer A, Soller K, Sakk V, Sacma M, Nemkov T, D'Alessandro A, Geiger H. pH regulates hematopoietic stem cell potential via?polyamines. EMBO Rep. 2023 05 04; 24(5):e55373. PMID: 36943011.
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    72. Cendali FI, Nemkov T, Lisk C, Lacroix IS, Nouraie SM, Zhang Y, Gordeuk VR, Buehler PW, Irwin D, D'Alessandro A. Metabolic correlates to critical speed in murine models of sickle cell disease. Front Physiol. 2023; 14:1151268. PMID: 37007990.
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    73. D'Alessandro A. Red Blood Cell Omics and Machine Learning in Transfusion Medicine: Singularity Is Near. Transfus Med Hemother. 2023 Jun; 50(3):174-183. PMID: 37434999.
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    74. Mian SA, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D, Morales V, Finch AJ, D'Alessandro A, Bianchi K, Wang J, Gallipoli P, Kordasti S, Kubasch AS, Cross M, Platzbecker U, Wiseman DH, Bonnet D, Bernard DG, Gribben JG, Rouault-Pierre K. Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia. Sci Transl Med. 2023 03; 15(685):eabn5135. PMID: 36857430.
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    75. Zhang H, D'Alessandro A, Li M, Reisz JA, Riddle S, Muralidhar A, Bull T, Zhao L, Gerasimovskaya E, Stenmark KR. Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension. Vascul Pharmacol. 2023 04; 149:107157. PMID: 36849042.
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    76. Masci VL, Stefanoni D, D'Alessandro A, Zambelli M, Modesti L, Pollini D, Ovidi E, Tiezzi A. Induction of Drug-Resistance and Production of a Culture Medium Able to Induce Drug-Resistance in Vinblastine Untreated Murine Myeloma Cells. Molecules. 2023 Feb 22; 28(5). PMID: 36903299.
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    77. Diaz AV, Matheny T, Stephenson D, Nemkov T, D'Alessandro A, Reis T. Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells. bioRxiv. 2023 Feb 18. PMID: 36824729.
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    78. Nash MJ, Dobrinskikh E, Janssen RC, Lovell MA, Schady DA, Levek C, Jones KL, D'Alessandro A, Kievit P, Aagaard KM, McCurdy CE, Gannon M, Friedman JE, Wesolowski SR. Maternal Western diet is associated with distinct preclinical pediatric NAFLD phenotypes in juvenile nonhuman primate offspring. Hepatol Commun. 2023 02 01; 7(2):e0014. PMID: 36691970.
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    79. DeBot M, Erickson C, Kelher M, Schaid TR, Moore EE, Sauaia A, Cralley A, LaCroix I, D'Alessandro A, Hansen K, Cohen MJ, Silliman CC, Coleman J. Platelet and cryoprecipitate transfusions from female donors improve coagulopathy in vitro. J Trauma Acute Care Surg. 2023 04 01; 94(4):497-503. PMID: 36728345.
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    80. Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. Author Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2023 Jan; 4(1):148. PMID: 36577897.
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    81. Thangaraju K, Setua S, Lisk C, Swindle D, Stephenson D, Dzieciatkowska M, Lamb DR, Moitra P, Pak D, Hassell K, George G, Nuss R, Davizon-Castillo P, Stenmark KR, D'Alessandro A, Irwin DC, Buehler PW. Extracellular Vesicle Size Reveals Cargo Specific to Coagulation and Inflammation in Pediatric and Adult Sickle Cell Disease. Clin Appl Thromb Hemost. 2023 Jan-Dec; 29:10760296231186144. PMID: 37469147.
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    82. Hoffman MC, Hunter SJ, D'Alessandro A, Christians U, Law AJ, Freedman R. Maternal Plasma Choline during Gestation and Small for Gestational Age Infants. Am J Perinatol. 2024 05; 41(S 01):e939-e948. PMID: 36584689.
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    83. Setua S, Thangaraju K, Dzieciatkowska M, Wilkerson RB, Nemkov T, Lamb DR, Tagaya Y, Boyer T, Rowden T, Doctor A, D'Alessandro A, Buehler PW. Coagulation potential and the integrated omics of extracellular vesicles from COVID-19 positive patient plasma. Sci Rep. 2022 12 23; 12(1):22191. PMID: 36564503.
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    84. Recktenwald SM, Simionato G, Lopes MGM, Gamboni F, Dzieciatkowska M, Meybohm P, Zacharowski K, von Knethen A, Wagner C, Kaestner L, D'Alessandro A, Quint S. Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19. Elife. 2022 12 20; 11. PMID: 36537079.
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    85. Schaid TR, LaCroix I, Hansen KC, D'Alessandro A, Moore EE, Sauaia A, Dzieciatkowska M, DeBot M, Cralley AL, Thielen O, Hallas W, Erickson C, Mitra S, Banerjee A, Jones K, Silliman CC, Cohen MJ. A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player. J Trauma Acute Care Surg. 2023 03 01; 94(3):361-370. PMID: 36730076.
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    86. Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2022 11; 3(11):1300-1317. PMID: 36434392.
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    87. Schaid TR, Cohen MJ, D'Alessandro A, Silliman CC, Moore EE, Sauaia A, Dzieciatkowska M, Hallas W, Thielen O, DeBot M, Cralley A, LaCroix I, Erickson C, Mitra S, Banerjee A, Jones K, Hansen KC. TRAUMA INDUCES INTRAVASCULAR HEMOLYSIS, EXACERBATED BY RED BLOOD CELL TRANSFUSION AND ASSOCIATED WITH DISRUPTED ARGININE-NITRIC OXIDE METABOLISM. Shock. 2023 01 01; 59(1):12-19. PMID: 36378232.
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    88. Moore A, Busch MP, Dziewulska K, Francis RO, Hod EA, Zimring JC, D'Alessandro A, Page GP. Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors. J Biol Chem. 2022 12; 298(12):102706. PMID: 36395887.
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    89. Jacob C, Kitagawa A, Signoretti C, Dzieciatkowska M, D'Alessandro A, Gupte A, Hossain S, D'Addario CA, Gupte R, Gupte SA. Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension. J Biol Chem. 2022 12; 298(12):102691. PMID: 36372233.
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    90. LaCroix IS, Cohen M, Moore EE, Dzieciatkowska M, Nemkov T, Schaid TR, Debot M, Jones K, Silliman CC, Hansen KC, D'Alessandro A. Omics Markers of Red Blood Cell Transfusion in Trauma. Int J Mol Sci. 2022 Nov 10; 23(22). PMID: 36430297.
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    91. Liao Y, Luo Z, Lin Y, Chen H, Chen T, Xu L, Orgurek S, Berry K, Dzieciatkowska M, Reisz JA, D'Alessandro A, Zhou W, Lu QR. PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism. Cell Death Dis. 2022 11 09; 13(11):943. PMID: 36351894.
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    92. Roma A, Tcheng M, Ahmed N, Walker S, Jayanth P, Minden MD, Hope K, Nekkar Rao PP, Luc J, Doxey AC, Reisz JA, Culp-Hill R, D'Alessandro A, Spagnuolo PA. Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia. Mol Cancer Res. 2022 11 03; 20(11):1659-1673. PMID: 35994381.
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    93. Hadley JB, Kelher MR, D'Alessandro A, Gamboni F, Hansen K, Coleman J, Jones K, Cohen M, Moore EE, Banerjee A, Silliman CC. A pilot study of the metabolic profiles of apheresis platelets modified by donor age and sex and in vitro short-term incubation with sex hormones. Transfusion. 2022 12; 62(12):2596-2608. PMID: 36309927.
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    94. Guntur VP, Nemkov T, de Boer E, Mohning MP, Baraghoshi D, Cendali FI, San-Mill?n I, Petrache I, D'Alessandro A. Signatures of Mitochondrial Dysfunction and Impaired Fatty Acid Metabolism in Plasma of Patients with Post-Acute Sequelae of COVID-19 (PASC). Metabolites. 2022 Oct 26; 12(11). PMID: 36355108.
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    95. Hay A, Dziewulska K, Gamboni F, Nerguizian D, Dzieciatkowska M, Zimring JC, D'Alessandro A. Hypoxic storage of murine red blood cells improves energy metabolism and post-transfusion recoveries. Blood Transfus. 2023 01; 21(1):50-61. PMID: 36346885.
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    96. Lima G, Shurlock J, Wang G, Karanikolou A, Sutehall S, Pitsiladis YP, D'Alessandro A. Metabolomic Profiling of Recombinant Erythropoietin (rHuEpo) in Trained Caucasian Athletes. Clin J Sport Med. 2023 09 01; 33(5):e123-e134. PMID: 36731031.
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    97. Nikulina M, Nemkov T, D'Alessandro A, Gaccione P, Yoshida T. A deep 96-well plate RBC storage platform for high-throughput screening of novel storage solutions. Front Physiol. 2022; 13:1004936. PMID: 36277188.
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    98. Rabcuka J, Blonski S, Meli A, Sowemimo-Coker S, Zaremba D, Stephenson D, Dzieciatkowska M, Nerguizian D, Cardigan R, Korczyk PM, Smethurst PA, D'Alessandro A, Swietach P. Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells. Blood Adv. 2022 09 27; 6(18):5415-5428. PMID: 35736672.
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    99. D'Alessandro A. Editorial: Rising stars in red blood cell physiology: 2022. Front Physiol. 2022; 13:1020144. PMID: 36160846.
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    100. Traxler L, Herdy JR, Stefanoni D, Eichhorner S, Pelucchi S, Sz?cs A, Santagostino A, Kim Y, Agarwal RK, Schlachetzki JCM, Glass CK, Lagerwall J, Galasko D, Gage FH, D'Alessandro A, Mertens J. Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. Cell Metab. 2022 09 06; 34(9):1248-1263.e6. PMID: 35987203.
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    101. Himbert S, D'Alessandro A, Qadri SM, Majcher MJ, Hoare T, Sheffield WP, Nagao M, Nagle JF, Rheinst?dter MC. The bending rigidity of the red blood cell cytoplasmic membrane. PLoS One. 2022; 17(8):e0269619. PMID: 35913930.
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    102. Miglio A, Maslanka M, Di Tommaso M, Rocconi F, Nemkov T, Buehler PW, Antognoni MT, Spitalnik SL, D'Alessandro A. ZOOMICS : comparative metabolomics of red blood cells from dogs, cows, horses and donkeys during refrigerated storage for up to 42 days. Blood Transfus. 2023 07; 21(4):314-326. PMID: 35969134.
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    103. Lee E, Redzic JS, Nemkov T, Saviola AJ, Dzieciatkowska M, Hansen KC, D'Alessandro A, Dinarello C, Eisenmesser EZ. Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions. Molecules. 2022 Jul 14; 27(14). PMID: 35889366.
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    104. Nemkov T, Skinner S, Diaw M, Diop S, Samb A, Connes P, D'Alessandro A. Plasma Levels of Acyl-Carnitines and Carboxylic Acids Correlate With Cardiovascular and Kidney Function in Subjects With Sickle Cell Trait. Front Physiol. 2022; 13:916197. PMID: 35910560.
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    105. de Bruin S, Peters AL, Wijnberge M, van Baarle FEHP, AbdelRahman AHA, Vermeulen C, Beuger BM, Reisz JA, D'Alessandro A, Vlaar APJ, de Korte D, van Bruggen R. Storage of red blood cells in alkaline PAGGGM improves metabolism but has no effect on recovery after transfusion. Blood Adv. 2022 07 12; 6(13):3899-3910. PMID: 35477178.
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    106. McClary WD, Catala A, Zhang W, Gamboni F, Dzieciatkowska M, Sidhu SS, D'Alessandro A, Catalano CE. A Designer Nanoparticle Platform for Controlled Intracellular Delivery of Bioactive Macromolecules: Inhibition of Ubiquitin-Specific Protease 7 in Breast Cancer Cells. ACS Chem Biol. 2022 07 15; 17(7):1853-1865. PMID: 35796308.
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    107. Arnold CG, Dylla L, Monte AA, Heard K, Heard S, D'Alessandro A, Reynolds K, Dart R, Rumack B, Sonn B. Metabolomic Evaluation of N-Acetyl-p-Benzoquinone Imine Protein Adduct Formation with Therapeutic Acetaminophen Administration: Sex-based Physiologic Differences. J Med Toxicol. 2022 10; 18(4):297-310. PMID: 35751009.
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    108. Guard SE, Chapnick DA, Poss ZC, Ebmeier CC, Jacobsen J, Nemkov T, Ball KA, Webb KJ, Simpson HL, Coleman S, Bunker E, Ramirez A, Reisz JA, Sievers R, Stowell MHB, D'Alessandro A, Liu X, Old WM. Multiomic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines. Mol Cell Proteomics. 2022 10; 21(10):100262. PMID: 35753663.
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    109. Antonelou MH, D'Alessandro A, Kriebardis AG. In Sickness and in Health: Erythrocyte Responses to Stress and Aging. Int J Mol Sci. 2022 Jun 23; 23(13). PMID: 35805962.
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    110. Tayachew B, Vanden Brink H, Garcia-Reyes Y, Rahat H, D'Alessandro A, Frank DN, Robertson CE, Silveira L, Kelsey M, Pyle L, Cree-Green M. Combined Oral Contraceptive Treatment Does Not Alter the Gut Microbiome but Affects Amino Acid Metabolism in Sera of Obese Girls With Polycystic Ovary Syndrome. Front Physiol. 2022; 13:887077. PMID: 35800349.
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    111. Cralley AL, Moore EE, Fox CJ, Kissau D, DeBot M, Schaid TR, Mitra S, Hom P, Fragoso M, Ghasabyan A, Erickson C, D'Alessandro A, Hansen KC, Cohen MJ, Silliman CC, Sauaia A. Zone 1 REBOA in a combat DCBI swine model does not worsen brain?injury. Surgery. 2022 08; 172(2):751-758. PMID: 35690490.
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    112. Patel SB, Nemkov T, D'Alessandro A, Welner RS. Deciphering Metabolic Adaptability of Leukemic Stem Cells. Front Oncol. 2022; 12:846149. PMID: 35756656.
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    113. Anastasiadi AT, Tzounakas VL, Dzieciatkowska M, Arvaniti VZ, Papageorgiou EG, Papassideri IS, Stamoulis K, D'Alessandro A, Kriebardis AG, Antonelou MH. Innate Variability in Physiological and Omics Aspects of the Beta Thalassemia Trait-Specific Donor Variation Effects. Front Physiol. 2022; 13:907444. PMID: 35755442.
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    114. Moriconi C, Dzieciatkowska M, Roy M, D'Alessandro A, Roingeard P, Lee JY, Gibb DR, Tredicine M, McGill MA, Qiu A, La Carpia F, Francis RO, Hod EA, Thomas T, Picard M, Akpan IJ, Luckey CJ, Zimring JC, Spitalnik SL, Hudson KE. Retention of functional mitochondria in mature red blood cells from patients with sickle cell disease. Br J Haematol. 2022 08; 198(3):574-586. PMID: 35670632.
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    115. Mandala A, Dobrinskikh E, Janssen RC, Fiehn O, D'Alessandro A, Friedman JE, Jonscher KR. Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD. Int J Mol Sci. 2022 May 27; 23(11). PMID: 35682720.
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    116. Schaid TR, Hansen KC, Sauaia A, Moore EE, DeBot M, Cralley AL, Erickson C, Silliman CC, Banerjee A, Ghasabyan A, Jones K, Lacroix I, Mitra S, D'Alessandro A, Cohen MJ. Postinjury complement C4 activation is associated with adverse outcomes and is potentially influenced by plasma resuscitation. J Trauma Acute Care Surg. 2022 11 01; 93(5):588-596. PMID: 35610738.
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    117. Nemkov T, Kingsley PD, Dzieciatkowska M, Malik J, McGrath KE, Hansen KC, D'Alessandro A, Palis J. Circulating primitive murine erythroblasts undergo complex proteomic and metabolomic changes during terminal maturation. Blood Adv. 2022 05 24; 6(10):3072-3089. PMID: 35139174.
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    118. Vigers T, Vinovskis C, Li LP, Prasad P, Heerspink H, D'Alessandro A, Reisz JA, Piani F, Cherney DZ, van Raalte DH, Nadeau KJ, Pavkov ME, Nelson RG, Pyle L, Bjornstad P. Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes. Pediatr Nephrol. 2023 01; 38(1):193-202. PMID: 35507146.
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    119. Song A, Wen AQ, Wen YE, Dzieciatkowska M, Kellems RE, Juneja HS, D'Alessandro A, Xia Y. p97 dysfunction underlies a loss of quality control of damaged membrane proteins and promotes oxidative stress and sickling in sickle cell disease. FASEB J. 2022 05; 36(5):e22246. PMID: 35405035.
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    120. Kim CY, Johnson H, Peltier S, Spitalnik SL, Hod EA, Francis RO, Hudson KE, Stone EF, Gordy DE, Fu X, Zimring JC, Amireault P, Buehler PW, Wilson RB, D'Alessandro A, Shchepinov MS, Thomas T. Deuterated Linoleic Acid Attenuates the RBC Storage Lesion in a Mouse Model of Poor RBC Storage. Front Physiol. 2022; 13:868578. PMID: 35557972.
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    121. Turner JA, Paton EL, Van Gulick R, Stefanoni D, Cendali F, Reisz J, Tobin RP, McCarter M, D'Alessandro A, Torres RM, Robinson WA, Couts KL, Schlaepfer IR. BRAF Modulates Lipid Use and Accumulation. Cancers (Basel). 2022 Apr 23; 14(9). PMID: 35565240.
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    122. Ferrero E, Villa A, Stefanoni D, Nemkov T, D'Alessandro A, Tengesdal I, Belloni D, Molteni R, Vergani B, De Luca G, Grassini G, Cangi MG, Dagna L, Doglioni C, Cavalli G, Ferrarini M. Immunometabolic activation of macrophages leads to cytokine production in the pathogenesis of KRAS-mutated histiocytosis. Rheumatology (Oxford). 2022 04 11; 61(4):e93-e96. PMID: 34919661.
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    123. Bertolone L, Shin HKH, Baek JH, Gao Y, Spitalnik SL, Buehler PW, D'Alessandro A. ZOOMICS: Comparative Metabolomics of Red Blood Cells From Guinea Pigs, Humans, and Non-human Primates During Refrigerated Storage for Up to 42 Days. Front Physiol. 2022; 13:845347. PMID: 35388289.
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    124. Galbraith MD, Kinning KT, Sullivan KD, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, Guo K, Wilson CC, Santiago ML, Monte AA, Bennett TD, Hansen KC, Hsieh EWY, D'Alessandro A, Espinosa JM. Specialized interferon action in COVID-19. Proc Natl Acad Sci U S A. 2022 03 15; 119(11). PMID: 35217532.
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    125. Nemkov T, Yoshida T, Nikulina M, D'Alessandro A. High-Throughput Metabolomics Platform for the Rapid Data-Driven Development of Novel Additive Solutions for Blood Storage. Front Physiol. 2022; 13:833242. PMID: 35360223.
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    126. Catala A, Stone M, Busch MP, D'Alessandro A. Reprogramming of red blood cell metabolism in Zika virus-infected donors. Transfusion. 2022 05; 62(5):1045-1064. PMID: 35285520.
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    127. Giordano AMS, Luciani M, Gatto F, Abou Alezz M, Begh? C, Della Volpe L, Migliara A, Valsoni S, Genua M, Dzieciatkowska M, Frati G, Tahraoui-Bories J, Giliani SC, Orcesi S, Fazzi E, Ostuni R, D'Alessandro A, Di Micco R, Merelli I, Lombardo A, Reijns MAM, Gromak N, Gritti A, Kajaste-Rudnitski A. DNA damage contributes to neurotoxic inflammation in Aicardi-Gouti?res syndrome astrocytes. J Exp Med. 2022 04 04; 219(4). PMID: 35262626.
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    128. Butera A, Roy M, Zampieri C, Mammarella E, Panatta E, Melino G, D'Alessandro A, Amelio I. p53-driven lipidome influences non-cell-autonomous lysophospholipids in pancreatic cancer. Biol Direct. 2022 03 08; 17(1):6. PMID: 35255936.
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    129. Anastasiadi AT, Arvaniti VZ, Paronis EC, Kostomitsopoulos NG, Stamoulis K, Papassideri IS, D'Alessandro A, Kriebardis AG, Tzounakas VL, Antonelou MH. Corpuscular Fragility and Metabolic Aspects of Freshly Drawn Beta-Thalassemia Minor RBCs Impact Their Physiology and Performance Post Transfusion: A Triangular Correlation Analysis In Vitro and In Vivo. Biomedicines. 2022 Feb 23; 10(3). PMID: 35327331.
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    130. Stephenson D, Nemkov T, Qadri SM, Sheffield WP, D'Alessandro A. Inductively-Coupled Plasma Mass Spectrometry-Novel Insights From an Old Technology Into Stressed Red Blood Cell Physiology. Front Physiol. 2022; 13:828087. PMID: 35197866.
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    131. Xu P, Chen C, Zhang Y, Dzieciatkowska M, Brown BC, Zhang W, Xie T, Abdulmalik O, Song A, Tong C, Qi H, Roach R, Kellems RE, D'Alessandro A, Xia Y. Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis. Cell Metab. 2022 02 01; 34(2):299-316.e6. PMID: 35108516.
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    132. Stotts MJ, Risbano MG, Gorham JD, D'Alessandro A. Red blood transfusion as a potential source for false-positive phosphatidylethanol levels. Transfusion. 2022 02; 62(2):506-508. PMID: 35146766.
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    194. Knight WE, Cao Y, Lin YH, Chi C, Bai B, Sparagna GC, Zhao Y, Du Y, Londono P, Reisz JA, Brown BC, Taylor MRG, Ambardekar AV, Cleveland JC, McKinsey TA, Jeong MY, Walker LA, Woulfe KC, D'Alessandro A, Chatfield KC, Xu H, Bristow MR, Buttrick PM, Song K. Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy. Stem Cell Reports. 2021 03 09; 16(3):519-533. PMID: 33636116.
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    196. Oatman N, Dasgupta N, Arora P, Choi K, Gawali MV, Gupta N, Parameswaran S, Salomone J, Reisz JA, Lawler S, Furnari F, Brennan C, Wu J, Sallans L, Gudelsky G, Desai P, Gebelein B, Weirauch MT, D'Alessandro A, Komurov K, Dasgupta B. Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Sci Adv. 2021 02; 7(7). PMID: 33568479.
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    197. Nemkov T, Stefanoni D, Bordbar A, Issaian A, Palsson BO, Dumont LJ, Hay A, Song A, Xia Y, Redzic JS, Eisenmesser EZ, Zimring JC, Kleinman S, Hansen KC, Busch MP, D'Alessandro A. Blood donor exposome and impact of common drugs on red blood cell metabolism. JCI Insight. 2021 02 08; 6(3). PMID: 33351786.
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    198. Hunter SK, Hoffman MC, D'Alessandro A, Wyrwa A, Noonan K, Zeisel SH, Law AJ, Freedman R. Prenatal choline, cannabis, and infection, and their association with offspring development of attention and social problems through 4 years of age. Psychol Med. 2022 10; 52(14):3019-3028. PMID: 33491615.
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    199. Nemkov T, Skinner SC, Nader E, Stefanoni D, Robert M, Cendali F, Stauffer E, Cibiel A, Boisson C, Connes P, D'Alessandro A. Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling. Int J Mol Sci. 2021 Jan 18; 22(2). PMID: 33477427.
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    200. Dong S, Wang Q, Kao YR, Diaz A, Tasset I, Kaushik S, Thiruthuvanathan V, Zintiridou A, Nieves E, Dzieciatkowska M, Reisz JA, Gavathiotis E, D'Alessandro A, Will B, Cuervo AM. Chaperone-mediated autophagy sustains haematopoietic stem-cell function. Nature. 2021 03; 591(7848):117-123. PMID: 33442062.
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    201. Dhagia V, Kitagawa A, Jacob C, Zheng C, D'Alessandro A, Edwards JG, Rocic P, Gupte R, Gupte SA. G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases. Am J Physiol Heart Circ Physiol. 2021 03 01; 320(3):H999-H1016. PMID: 33416454.
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    202. McKinney C, Ellison M, Briones NJ, Baroffio A, Murphy J, Tran AD, Reisz JA, D'Alessandro A, Ambruso DR. Metabolic abnormalities in G6PC3-deficient human neutrophils result in severe functional defects. Blood Adv. 2020 12 08; 4(23):5888-5901. PMID: 33259599.
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    203. Rice SA, Ten Have GAM, Reisz JA, Gehrke S, Stefanoni D, Frare C, Barati Z, Coker RH, D'Alessandro A, Deutz NEP, Drew KL. Nitrogen recycling buffers against ammonia toxicity from skeletal muscle breakdown in hibernating arctic ground squirrels. Nat Metab. 2020 12; 2(12):1459-1471. PMID: 33288952.
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    204. Galbraith MD, Kinning KT, Sullivan KD, Baxter R, Araya P, Jordan KR, Russell S, Smith KP, Granrath RE, Shaw J, Dzieciatkowska M, Ghosh T, Monte AA, D'Alessandro A, Hansen KC, Bennett TD, Hsieh EWY, Espinosa JM. Seroconversion stages COVID19 into distinct pathophysiological states. medRxiv. 2020 Dec 07. PMID: 33330890.
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    205. Anderson CC, Marentette JO, Rauniyar AK, Prutton KM, Khatri M, Matheson C, Reisz JA, Reigan P, D'Alessandro A, Roede JR. Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinson's disease. Free Radic Biol Med. 2021 01; 162:65-76. PMID: 33279619.
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    206. Henriksen HH, McGarrity S, Sigur?ard?ttir RS, Nemkov T, D'Alessandro A, Palsson BO, Stensballe J, Wade CE, Rolfsson ?, Johansson PI. Metabolic Systems Analysis of Shock-Induced Endotheliopathy (SHINE) in Trauma: A New Research Paradigm. Ann Surg. 2020 12; 272(6):1140-1148. PMID: 31274658.
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    207. Lonnemann N, Hosseini S, Marchetti C, Skouras DB, Stefanoni D, D'Alessandro A, Dinarello CA, Korte M. The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2020 12 15; 117(50):32145-32154. PMID: 33257576.
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    208. Tzounakas VL, Dzieciatkowska M, Anastasiadi AT, Karadimas DG, Vergaki A, Siourounis P, Stamoulis K, Papassideri IS, Kriebardis AG, D'Alessandro A, Antonelou MH. Red cell proteasome modulation by storage, redox metabolism and transfusion. Blood Transfus. 2022 01; 20(1):27-39. PMID: 33263521.
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    209. D'Alessandro A. Benford's law and metabolomics: A tale of numbers and blood. Transfus Apher Sci. 2020 Dec; 59(6):103019. PMID: 33246837.
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    210. Joshi M, Kim J, D'Alessandro A, Monk E, Bruce K, Elajaili H, Nozik-Grayck E, Goodspeed A, Costello JC, Schlaepfer IR. CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer. Cancers (Basel). 2020 Nov 18; 12(11). PMID: 33218188.
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    211. Nunns GR, Vigneshwar N, Kelher MR, Stettler GR, Gera L, Reisz JA, D'Alessandro A, Ryon J, Hansen KC, Gamboni F, Moore EE, Peltz ED, Cohen MJ, Jones KL, Sauaia A, Liang X, Banerjee A, Ghasabyan A, Chandler JG, Rodawig S, Jones C, Eitel A, Hom P, Silliman CC. Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-mediated ARDS. Ann Surg. 2022 12 01; 276(6):e944-e954. PMID: 33214479.
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    212. Hazegh K, Fang F, Bravo MD, Tran JQ, Muench MO, Jackman RP, Roubinian N, Bertolone L, D'Alessandro A, Dumont L, Page GP, Kanias T. Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress. Transfusion. 2021 02; 61(2):435-448. PMID: 33146433.
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    213. Morgell A, Reisz JA, Ateeb Z, Davanian H, Reinsbach SE, Halimi A, Gaiser R, Valente R, Arnelo U, Chiaro MD, S?llberg Chen M, D'Alessandro A. Metabolic characterization of plasma and cyst fluid from cystic precursors to pancreatic cancer patients reveal metabolic signatures of bacterial infection. medRxiv. 2020 Nov 04. PMID: 33173899.
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    214. Culp-Hill R, D'Alessandro A, Pietras EM. Extinguishing the Embers: Targeting AML Metabolism. Trends Mol Med. 2021 04; 27(4):332-344. PMID: 33121874.
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    215. Thomas T, Stefanoni D, Dzieciatkowska M, Issaian A, Nemkov T, Hill RC, Francis RO, Hudson KE, Buehler PW, Zimring JC, Hod EA, Hansen KC, Spitalnik SL, D'Alessandro A. Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients. J Proteome Res. 2020 11 06; 19(11):4455-4469. PMID: 33103907.
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    216. Stevens BM, Jones CL, Pollyea DA, Culp-Hill R, D'Alessandro A, Winters A, Krug A, Abbott D, Goosman M, Pei S, Ye H, Gillen AE, Becker MW, Savona MR, Smith C, Jordan CT. Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells. Nat Cancer. 2020 12; 1(12):1176-1187. PMID: 33884374.
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    217. Bertolone L, Shin HK, Stefanoni D, Baek JH, Gao Y, Morrison EJ, Nemkov T, Thomas T, Francis RO, Hod EA, Zimring JC, Yoshida T, Karafin M, Schwartz J, Hudson KE, Spitalnik SL, Buehler PW, D'Alessandro A. ZOOMICS: Comparative Metabolomics of Red Blood Cells From Old World Monkeys and Humans. Front Physiol. 2020; 11:593841. PMID: 33192610.
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    218. Montgomery TL, K?nstner A, Kennedy JJ, Fang Q, Asarian L, Culp-Hill R, D'Alessandro A, Teuscher C, Busch H, Krementsov DN. Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27516-27527. PMID: 33077601.
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    219. Alexander K, Hazegh K, Fang F, Sinchar D, Kiss JE, Page GP, D'Alessandro A, Kanias T. Testosterone replacement therapy in blood donors modulates erythrocyte metabolism and susceptibility to hemolysis in cold storage. Transfusion. 2021 01; 61(1):108-123. PMID: 33073382.
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    220. D'Alessandro A, Stefanoni D, Slichter SJ, Fu X, Zimring JC. The impact of donor sex and age on stored platelet metabolism and post-transfusion recovery. Blood Transfus. 2021 05; 19(3):216-223. PMID: 33085601.
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    221. Ye H, Minhajuddin M, Krug A, Pei S, Chou CH, Culp-Hill R, Ponder J, De Bloois E, Schniedewind B, Amaya ML, Inguva A, Stevens BM, Pollyea DA, Christians U, Grimes HL, D'Alessandro A, Jordan CT. The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG. Cancer Discov. 2021 02; 11(2):500-519. PMID: 33028621.
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    222. Burchill MA, Finlon JM, Goldberg AR, Gillen AE, Dahms PA, McMahan RH, Tye A, Winter AB, Reisz JA, Bohrnsen E, Schafer JB, D'Alessandro A, Orlicky DJ, Kriss MS, Rosen HR, McCullough RL, Jir?n Tamburini BA. Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System. Cell Mol Gastroenterol Hepatol. 2021; 11(2):573-595. PMID: 32961356.
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    223. Clayton ZS, Brunt VE, Hutton DA, VanDongen NS, D'Alessandro A, Reisz JA, Ziemba BP, Seals DR. Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment. JACC CardioOncol. 2020 Sep; 2(3):475-488. PMID: 33073250.
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    224. Ding Y, Ball KA, Webb KJ, Gao Y, D'Alessandro A, Old WM, Stowell MHB, Ding X. On-Chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability. Small. 2020 10; 16(41):e2003506. PMID: 32893496.
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    225. Rozance PJ, Jones AK, Bourque SL, D'Alessandro A, Hay WW, Brown LD, Wesolowski SR. Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver. Am J Physiol Endocrinol Metab. 2020 10 01; 319(4):E721-E733. PMID: 32830555.
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    226. Jones CL, Stevens BM, Pollyea DA, Culp-Hill R, Reisz JA, Nemkov T, Gehrke S, Gamboni F, Krug A, Winters A, Pei S, Gustafson A, Ye H, Inguva A, Amaya M, Minhajuddin M, Abbott D, Becker MW, DeGregori J, Smith CA, D'Alessandro A, Jordan CT. Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells. Cell Stem Cell. 2020 11 05; 27(5):748-764.e4. PMID: 32822582.
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    227. Mykhailova O, Olafson C, Turner TR, D'Alessandro A, Acker JP. Donor-dependent aging of young and old red blood cell subpopulations: Metabolic and functional heterogeneity. Transfusion. 2020 11; 60(11):2633-2646. PMID: 32812244.
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    228. D'Alessandro A, Thomas T, Dzieciatkowska M, Hill RC, Francis RO, Hudson KE, Zimring JC, Hod EA, Spitalnik SL, Hansen KC. Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level. J Proteome Res. 2020 11 06; 19(11):4417-4427. PMID: 32786691.
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    229. Thomas T, Stefanoni D, Reisz JA, Nemkov T, Bertolone L, Francis RO, Hudson KE, Zimring JC, Hansen KC, Hod EA, Spitalnik SL, D'Alessandro A. COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status. JCI Insight. 2020 07 23; 5(14). PMID: 32559180.
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    230. Thomas T, Stefanoni D, Dzieciatkowska M, Issaian A, Nemkov T, Hill RC, Francis RO, Hudson KE, Buehler PW, Zimring JC, Hod EA, Hansen KC, Spitalnik SL, D'Alessandro A. Evidence for structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients. medRxiv. 2020 Jun 30. PMID: 32637980.
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    231. Kitagawa A, Kizub I, Jacob C, Michael K, D'Alessandro A, Reisz JA, Grzybowski M, Geurts AM, Rocic P, Gupte R, Miano JM, Gupte SA. CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean G6PD Variant. Hypertension. 2020 08; 76(2):523-532. PMID: 32507041.
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    232. San-Mill?n I, Stefanoni D, Martinez JL, Hansen KC, D'Alessandro A, Nemkov T. Metabolomics of Endurance Capacity in World Tour Professional Cyclists. Front Physiol. 2020; 11:578. PMID: 32581847.
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    233. Freedman R, Hunter SK, Law AJ, D'Alessandro A, Noonan K, Wyrwa A, Camille Hoffman M. Maternal choline and respiratory coronavirus effects on fetal brain development. J Psychiatr Res. 2020 09; 128:1-4. PMID: 32474140.
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    234. Sayama S, Song A, Brown BC, Couturier J, Cai X, Xu P, Chen C, Zheng Y, Iriyama T, Sibai B, Longo M, Kellems RE, D'Alessandro A, Xia Y. Maternal erythrocyte ENT1-mediated AMPK activation counteracts placental hypoxia and supports fetal growth. JCI Insight. 2020 05 21; 5(10). PMID: 32434995.
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    235. Thomas T, Stefanoni D, Reisz JA, Nemkov T, Bertolone L, Francis RO, Hudson KE, Zimring JC, Hansen KC, Hod EA, Spitalnik SL, D'Alessandro A. COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status. medRxiv. 2020 May 16. PMID: 32511571.
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    236. D'Alessandro A, Fu X, Reisz JA, Kanias T, Page GP, Stone M, Kleinman S, Zimring JC, Busch M. Stored RBC metabolism as a function of caffeine levels. Transfusion. 2020 06; 60(6):1197-1211. PMID: 32394461.
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    237. Stefanoni D, Fu X, Reisz JA, Kanias T, Nemkov T, Page GP, Dumont L, Roubinian N, Stone M, Kleinman S, Busch M, Zimring JC, D'Alessandro A. Nicotine exposure increases markers of oxidant stress in stored red blood cells from healthy donor volunteers. Transfusion. 2020 06; 60(6):1160-1174. PMID: 32385854.
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    238. D'Alessandro A, Fu X, Reisz JA, Stone M, Kleinman S, Zimring JC, Busch M. Ethyl glucuronide, a marker of alcohol consumption, correlates with metabolic markers of oxidant stress but not with hemolysis in stored red blood cells from healthy blood donors. Transfusion. 2020 06; 60(6):1183-1196. PMID: 32385922.
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    239. D'Alessandro A, Xia Y. Erythrocyte adaptive metabolic reprogramming under physiological and pathological hypoxia. Curr Opin Hematol. 2020 05; 27(3):155-162. PMID: 32141895.
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    240. Francis RO, D'Alessandro A, Eisenberger A, Soffing M, Yeh R, Coronel E, Sheikh A, Rapido F, La Carpia F, Reisz JA, Gehrke S, Nemkov T, Thomas T, Schwartz J, Divgi C, Kessler D, Shaz BH, Ginzburg Y, Zimring JC, Spitalnik SL, Hod EA. Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion. J Clin Invest. 2020 05 01; 130(5):2270-2285. PMID: 31961822.
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    241. Catala A, Youssef LA, Reisz JA, Dzieciatkowska M, Powers NE, Marchetti C, Karafin M, Zimring JC, Hudson KE, Hansen KC, Spitalnik SL, D'Alessandro A. Metabolic Reprogramming of Mouse Bone Marrow Derived Macrophages Following Erythrophagocytosis. Front Physiol. 2020; 11:396. PMID: 32425810.
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    242. Zhou H, Blevins MA, Hsu JY, Kong D, Galbraith MD, Goodspeed A, Culp-Hill R, Oliphant MUJ, Ramirez D, Zhang L, Trinidad-Pineiro J, Mathews Griner L, King R, Barnaeva E, Hu X, Southall NT, Ferrer M, Gustafson DL, Regan DP, D'Alessandro A, Costello JC, Patnaik S, Marugan J, Zhao R, Ford HL. Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis. Cancer Res. 2020 06 15; 80(12):2689-2702. PMID: 32341035.
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    243. Bertolone L, Roy MK, Hay AM, Morrison EJ, Stefanoni D, Fu X, Kanias T, Kleinman S, Dumont LJ, Stone M, Nemkov T, Busch MP, Zimring JC, D'Alessandro A. Impact of taurine on red blood cell metabolism and implications for blood storage. Transfusion. 2020 06; 60(6):1212-1226. PMID: 32339326.
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    244. Xie T, Chen C, Peng Z, Brown BC, Reisz JA, Xu P, Zhou Z, Song A, Zhang Y, Bogdanov MV, Kellems RE, D'Alessandro A, Zhang W, Xia Y. Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies. Circ Res. 2020 07 17; 127(3):360-375. PMID: 32284030.
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    245. Joshi SR, Kitagawa A, Jacob C, Hashimoto R, Dhagia V, Ramesh A, Zheng C, Zhang H, Jordan A, Waddell I, Leopold J, Hu CJ, McMurtry IF, D'Alessandro A, Stenmark KR, Gupte SA. Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation. Am J Physiol Lung Cell Mol Physiol. 2020 04 01; 318(4):L773-L786. PMID: 32159369.
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    246. Williams AT, Jani VP, Nemkov T, Lucas A, Yoshida T, Dunham A, D'Alessandro A, Cabrales P. Transfusion of Anaerobically or Conventionally Stored Blood After Hemorrhagic Shock. Shock. 2020 03; 53(3):352-362. PMID: 31478989.
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    247. Nemkov T, Qadri SM, Sheffield WP, D'Alessandro A. Decoding the metabolic landscape of pathophysiological stress-induced cell death in anucleate red blood cells. Blood Transfus. 2020 03; 18(2):130-142. PMID: 32203008.
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    248. D'Alessandro A, Yoshida T, Nestheide S, Nemkov T, Stocker S, Stefanoni D, Mohmoud F, Rugg N, Dunham A, Cancelas JA. Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery. Transfusion. 2020 04; 60(4):786-798. PMID: 32104927.
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    249. Gillette CM, Hazegh KE, Nemkov T, Stefanoni D, D'Alessandro A, Taliaferro JM, Reis T. Gene-Diet Interactions: Dietary Rescue of Metabolic Effects in spen-Depleted Drosophila melanogaster. Genetics. 2020 04; 214(4):961-975. PMID: 32107279.
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    250. Janssen WJ, Danhorn T, Harris C, Mould KJ, Lee FF, Hedin BR, D'Alessandro A, Leach SM, Alper S. Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages. G3 (Bethesda). 2020 02 06; 10(2):555-567. PMID: 31810980.
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    251. Pei S, Pollyea DA, Gustafson A, Stevens BM, Minhajuddin M, Fu R, Riemondy KA, Gillen AE, Sheridan RM, Kim J, Costello JC, Amaya ML, Inguva A, Winters A, Ye H, Krug A, Jones CL, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers JR, Ashton JM, Nemkov T, D'Alessandro A, Gutman JA, Ramsey HE, Savona MR, Smith CA, Jordan CT. Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia. Cancer Discov. 2020 04; 10(4):536-551. PMID: 31974170.
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    252. D'Alessandro A, Thomas KA, Stefanoni D, Gamboni F, Shea SM, Reisz JA, Spinella PC. Metabolic phenotypes of standard and cold-stored platelets. Transfusion. 2020 06; 60 Suppl 3:S96-S106. PMID: 31880330.
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    253. Hunter SK, Hoffman MC, D'Alessandro A, Noonan K, Wyrwa A, Freedman R, Law AJ. Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development. Psychol Med. 2021 02; 51(3):450-459. PMID: 31787129.
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    254. Yan D, Franzini A, Pomicter AD, Halverson BJ, Antelope O, Mason CC, Ahmann JM, Senina AV, Vellore NA, Jones CL, Zabriskie MS, Than H, Xiao MJ, van Scoyk A, Patel AB, Clair PM, Heaton WL, Owen SC, Andersen JL, Egbert CM, Reisz JA, D'Alessandro A, Cox JE, Gantz KC, Redwine HM, Iyer SM, Khorashad JS, Rajabi N, Olsen CA, O'Hare T, Deininger MW. SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA. Blood Cancer Discov. 2021 05; 2(3):266-287. PMID: 34027418.
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    255. Ballak DB, Brunt VE, Sapinsley ZJ, Ziemba BP, Richey JJ, Zigler MC, Johnson LC, Gioscia-Ryan RA, Culp-Hill R, Eisenmesser EZ, D'Alessandro A, Dinarello CA, Seals DR. Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice. Aging Cell. 2020 01; 19(1):e13074. PMID: 31755162.
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    256. Abraham AD, Esquer H, Zhou Q, Tomlinson N, Hamill BD, Abbott JM, Li L, Pike LA, Rinaldetti S, Ramirez DA, Lunghofer PJ, Gomez JD, Schaack J, Nemkov T, D'Alessandro A, Hansen KC, Gustafson DL, Messersmith WA, LaBarbera DV. Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer. J Med Chem. 2019 11 27; 62(22):10182-10203. PMID: 31675229.
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    257. Johnson LC, Parker K, Aguirre BF, Nemkov TG, D'Alessandro A, Johnson SA, Seals DR, Martens CR. The plasma metabolome as a predictor of biological aging in humans. Geroscience. 2019 12; 41(6):895-906. PMID: 31707594.
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    258. Stefanoni D, Shin HKH, Baek JH, Champagne DP, Nemkov T, Thomas T, Francis RO, Zimring JC, Yoshida T, Reisz JA, Spitalnik SL, Buehler PW, D'Alessandro A. Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage. Haematologica. 2020 08; 105(8):2174-2186. PMID: 31699790.
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    259. Powers RK, Culp-Hill R, Ludwig MP, Smith KP, Waugh KA, Minter R, Tuttle KD, Lewis HC, Rachubinski AL, Granrath RE, Carmona-Iragui M, Wilkerson RB, Kahn DE, Joshi M, Lle? A, Blesa R, Fortea J, D'Alessandro A, Costello JC, Sullivan KD, Espinosa JM. Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors. Nat Commun. 2019 10 18; 10(1):4766. PMID: 31628327.
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    260. Sonn BJ, Saben JL, McWilliams G, Shelton SK, Flaten HK, D'Alessandro A, Monte AA. Predicting response to lisinopril in treating hypertension: a pilot study. Metabolomics. 2019 10 03; 15(10):133. PMID: 31583478.
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    261. La Carpia F, Wojczyk BS, Annavajhala MK, Rebbaa A, Culp-Hill R, D'Alessandro A, Freedberg DE, Uhlemann AC, Hod EA. Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron. NPJ Biofilms Microbiomes. 2019; 5(1):26. PMID: 31583109.
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    262. Chang EI, Wesolowski SR, Gilje EA, Baker PR, Reisz JA, D'Alessandro A, Hay WW, Rozance PJ, Brown LD. Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb. Am J Physiol Regul Integr Comp Physiol. 2019 11 01; 317(5):R615-R629. PMID: 31483682.
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    263. Nohara K, Nemkov T, D'Alessandro A, Yoo SH, Chen Z. Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice. Int J Mol Sci. 2019 Sep 01; 20(17). PMID: 31480535.
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    264. Nohara K, Mallampalli V, Nemkov T, Wirianto M, Yang J, Ye Y, Sun Y, Han L, Esser KA, Mileykovskaya E, D'Alessandro A, Green CB, Takahashi JS, Dowhan W, Yoo SH, Chen Z. Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge. Nat Commun. 2019 08 28; 10(1):3923. PMID: 31462679.
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    265. Moore HB, Culp-Hill R, Reisz JA, Lawson PJ, Sauaia A, Schulick RD, Del Chiaro M, Nydam TL, Moore EE, Hansen KC, D'Alessandro A. The metabolic time line of pancreatic cancer: Opportunities to improve early detection of adenocarcinoma. Am J Surg. 2019 12; 218(6):1206-1212. PMID: 31514959.
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    266. Howie HL, Hay AM, de Wolski K, Waterman H, Lebedev J, Fu X, Culp-Hill R, D'Alessandro A, Gorham JD, Ranson MS, Roback JD, Thomson PC, Zimring JC. Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice. Blood Adv. 2019 08 13; 3(15):2272-2285. PMID: 31350307.
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    267. Gehrke S, Shah N, Gamboni F, Kamyszek R, Srinivasan AJ, Gray A, Landrigan M, Welsby I, D'Alessandro A. Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients. Transfusion. 2019 10; 59(10):3102-3112. PMID: 31385330.
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    268. Hoffman MC, Hunter SK, D'Alessandro A, Noonan K, Wyrwa A, Freedman R. Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring. Psychol Med. 2020 07; 50(10):1716-1726. PMID: 31364525.
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    269. Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J. TNF-a-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood. 2019 08 29; 134(9):727-740. PMID: 31311815.
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    270. Thwe PM, Pelgrom LR, Cooper R, Beauchamp S, Reisz JA, D'Alessandro A, Everts B, Amiel E. Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses. Cell Metab. 2019 Jul 02; 30(1):225. PMID: 31269426.
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    271. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs NF, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. Author Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2019 Jul 01; 10(1):2965. PMID: 31263097.
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    272. D'Alessandro A, Liumbruno G. Personalised Transfusion Medicine. Blood Transfus. 2019 07; 17(4):255-257. PMID: 31385798.
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    273. Morrison EJ, Champagne DP, Dzieciatkowska M, Nemkov T, Zimring JC, Hansen KC, Guan F, Huffman DM, Santambrogio L, D'Alessandro A. Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells. Nutrients. 2019 Jun 14; 11(6). PMID: 31207887.
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    274. D'Alessandro A, Hansen KC, Eisenmesser EZ, Zimring JC. Protect, repair, destroy or sacrifice: a role of oxidative stress biology in inter-donor variability of blood storage? Blood Transfus. 2019 07; 17(4):281-288. PMID: 31184577.
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    275. Jones CL, Stevens BM, D'Alessandro A, Culp-Hill R, Reisz JA, Pei S, Gustafson A, Khan N, DeGregori J, Pollyea DA, Jordan CT. Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II. Blood. 2019 07 25; 134(4):389-394. PMID: 31101624.
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    276. Gaikwad H, Wang G, Smith WJ, Alexander KL, D'Alessandro A, Zhang W, Purev E, Simberg D. Clickable Methyltetrazine-Indocarbocyanine Lipids: A Multicolor Tool Kit for Efficient Modifications of Cell Membranes. Bioconjug Chem. 2019 08 21; 30(8):2106-2114. PMID: 31050882.
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    277. Nechiporuk T, Kurtz SE, Nikolova O, Liu T, Jones CL, D'Alessandro A, Culp-Hill R, d'Almeida A, Joshi SK, Rosenberg M, Tognon CE, Danilov AV, Druker BJ, Chang BH, McWeeney SK, Tyner JW. The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells. Cancer Discov. 2019 07; 9(7):910-925. PMID: 31048320.
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    278. Schmitt LR, Henderson R, Barrett A, Darula Z, Issaian A, D'Alessandro A, Clendenen N, Hansen KC. Mass spectrometry-based molecular mapping of native FXIIIa cross-links in insoluble fibrin clots. J Biol Chem. 2019 05 31; 294(22):8773-8778. PMID: 31028172.
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    279. Francis RO, Mahajan S, Rapido F, La Carpia F, Soffing M, Divgi C, Yeh R, Mintz A, Leslie L, Agrest I, Karafin MS, Ginzburg Y, Shaz BH, Spitalnik SL, Schwartz J, Thomas T, Fu X, Amireault P, Buffet P, Zimring JC, D'Alessandro A, Hod EA. Reexamination of the chromium-51-labeled posttransfusion red blood cell recovery method. Transfusion. 2019 07; 59(7):2264-2275. PMID: 31002399.
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    280. Adane B, Ye H, Khan N, Pei S, Minhajuddin M, Stevens BM, Jones CL, D'Alessandro A, Reisz JA, Zaberezhnyy V, Gasparetto M, Ho TC, Kelly KK, Myers JR, Ashton JM, Siegenthaler J, Kume T, Campbell EL, Pollyea DA, Becker MW, Jordan CT. The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells. Cell Rep. 2019 04 02; 27(1):238-254.e6. PMID: 30943405.
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    281. Gregory MA, Nemkov T, Park HJ, Zaberezhnyy V, Gehrke S, Adane B, Jordan CT, Hansen KC, D'Alessandro A, DeGregori J. Targeting Glutamine Metabolism and Redox State for Leukemia Therapy. Clin Cancer Res. 2019 07 01; 25(13):4079-4090. PMID: 30940653.
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    282. D'Alessandro A, Reisz JA, Zhang Y, Gehrke S, Alexander K, Kanias T, Triulzi DJ, Donadee C, Barge S, Badlam J, Jain S, Risbano MG, Gladwin MT. Effects of aged stored autologous red blood cells on human plasma metabolome. Blood Adv. 2019 03 26; 3(6):884-896. PMID: 30890545.
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    283. Freedman R, Hunter SK, Law AJ, Wagner BD, D'Alessandro A, Christians U, Noonan K, Wyrwa A, Hoffman MC. Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development. J Pediatr. 2019 05; 208:198-206.e2. PMID: 30879727.
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    284. D'Alessandro A, Zimring JC, Busch M. Chronological storage age and metabolic age of stored red blood cells: are they the same? Transfusion. 2019 05; 59(5):1620-1623. PMID: 30865302.
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    285. Hoffman MC, Olincy A, D'Alessandro A, Reisz JA, Hansen KC, Hunter SK, Freedman R, Ross RG. Effects of phosphatidylcholine and betaine supplements on women's serum choline. J Nutr Intermed Metab. 2019 Jun; 16. PMID: 36330042.
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    286. Gehrke S, Rice S, Stefanoni D, Wilkerson RB, Nemkov T, Reisz JA, Hansen KC, Lucas A, Cabrales P, Drew K, D'Alessandro A. Red Blood Cell Metabolic Responses to Torpor and Arousal in the Hibernator Arctic Ground Squirrel. J Proteome Res. 2019 04 05; 18(4):1827-1841. PMID: 30793910.
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    287. Pham-Danis C, Gehrke S, Danis E, Rozhok AI, Daniels MW, Gao D, Collins C, Paola JTD, D'Alessandro A, DeGregori J. Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC. Mol Cancer Res. 2019 06; 17(6):1351-1364. PMID: 30808730.
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    288. Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT. Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells. Cancer Cell. 2019 Feb 11; 35(2):333-335. PMID: 30753831.
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    289. Moore HB, D'Alessandro A, Moore EE, Wither M, Lawson PJ, Huebner BR, Hansen K, Choudhury R, Nydam TL. Increase in post-reperfusion sensitivity to tissue plasminogen activator-mediated fibrinolysis during liver transplantation is associated with abnormal metabolic changes and increased blood product utilisation. Blood Transfus. 2019 07; 17(4):312-320. PMID: 30747704.
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    290. Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney Int. 2019 03; 95(3):590-610. PMID: 30709662.
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    291. D'Alessandro A. From omics technologies to personalized transfusion medicine. Expert Rev Proteomics. 2019 03; 16(3):215-225. PMID: 30654673.
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    292. Lana A, Alexander K, Castagna A, D'Alessandro A, Morandini F, Pizzolo F, Zorzi F, Mulatero P, Zolla L, Olivieri O. Urinary Metabolic Signature of Primary Aldosteronism: Gender and Subtype-Specific Alterations. Proteomics Clin Appl. 2019 07; 13(4):e1800049. PMID: 30580498.
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    293. Yoshida T, Prudent M, D'alessandro A. Red blood cell storage lesion: causes and potential clinical consequences. Blood Transfus. 2019 01; 17(1):27-52. PMID: 30653459.
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    294. Nemkov T, Reisz JA, Gehrke S, Hansen KC, D'Alessandro A. High-Throughput Metabolomics: Isocratic and Gradient Mass Spectrometry-Based Methods. Methods Mol Biol. 2019; 1978:13-26. PMID: 31119654.
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    295. Reisz JA, Zheng C, D'Alessandro A, Nemkov T. Untargeted and Semi-targeted Lipid Analysis of Biological Samples Using Mass Spectrometry-Based Metabolomics. Methods Mol Biol. 2019; 1978:121-135. PMID: 31119660.
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    296. Rogers SC, Dosier LB, McMahon TJ, Zhu H, Timm D, Zhang H, Herbert J, Atallah J, Palmer GM, Cook A, Ernst M, Prakash J, Terng M, Towfighi P, Doctor R, Said A, Joens MS, Fitzpatrick JAJ, Hanna G, Lin X, Reisz JA, Nemkov T, D'Alessandro A, Doctor A. Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes. PLoS One. 2018; 13(12):e0209201. PMID: 30576340.
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    297. Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D'Alessandro A, Lowe SW, Prives C. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 2019 01 24; 176(3):564-580.e19. PMID: 30580964.
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    298. Clendenen N, Nunns GR, Moore EE, Gonzalez E, Chapman M, Reisz JA, Peltz E, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Silliman CC, Hansen K, Banerjee A, D'Alessandro A, Moore HB. Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements. Blood Transfus. 2019 09; 17(5):347-356. PMID: 30747701.
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    299. Sheridan RM, Fong N, D'Alessandro A, Bentley DL. Widespread Backtracking by RNA Pol II Is a Major Effector of Gene Activation, 5' Pause Release, Termination, and Transcription Elongation Rate. Mol Cell. 2019 01 03; 73(1):107-118.e4. PMID: 30503775.
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    300. Pollyea DA, Stevens BM, Jones CL, Winters A, Pei S, Minhajuddin M, D'Alessandro A, Culp-Hill R, Riemondy KA, Gillen AE, Hesselberth JR, Abbott D, Schatz D, Gutman JA, Purev E, Smith C, Jordan CT. Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia. Nat Med. 2018 12; 24(12):1859-1866. PMID: 30420752.
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    301. Jones CL, Stevens BM, D'Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Adane B, Ye H, Krug A, Reinhold D, Smith C, DeGregori J, Pollyea DA, Jordan CT. Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells. Cancer Cell. 2018 11 12; 34(5):724-740.e4. PMID: 30423294.
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    302. Karafin MS, Fu X, D'Alessandro A, Thomas T, Hod EA, Zimring JC, Field JJ, Francis RO. The clinical impact of glucose-6-phosphate dehydrogenase deficiency in patients with sickle cell disease. Curr Opin Hematol. 2018 11; 25(6):494-499. PMID: 30239377.
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    303. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs N, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 10 26; 9(1):4462. PMID: 30367045.
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    304. D'Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo Y, Page G, Gladwin MT, Kleinman S, Lanteri M, Stone M, Busch M, Zimring JC. Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics. Transfusion. 2019 01; 59(1):89-100. PMID: 30353560.
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    305. Nemkov T, Reisz JA, Xia Y, Zimring JC, D'Alessandro A. Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport. Expert Rev Proteomics. 2018 11; 15(11):855-864. PMID: 30278801.
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    306. Reisz JA, Nemkov T, Dzieciatkowska M, Culp-Hill R, Stefanoni D, Hill RC, Yoshida T, Dunham A, Kanias T, Dumont LJ, Busch M, Eisenmesser EZ, Zimring JC, Hansen KC, D'Alessandro A. Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. Transfusion. 2018 12; 58(12):2978-2991. PMID: 30312994.
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    307. Nemkov T, D'Alessandro A, Reisz JA. Metabolic underpinnings of leukemia pathology and treatment. Cancer Rep (Hoboken). 2019 04; 2(2):e1139. PMID: 32721091.
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    308. Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM. Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2018 10; 59(4):479-489. PMID: 29851508.
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    309. Wesolowski SR, Mulligan CM, Janssen RC, Baker PR, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 12; 18:25-41. PMID: 30337225.
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    310. Culp-Hill R, Srinivasan AJ, Gehrke S, Kamyszek R, Ansari A, Shah N, Welsby I, D'Alessandro A. Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism. Transfusion. 2018 12; 58(12):2797-2806. PMID: 30265764.
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    311. Rogers TJ, Christenson JL, Greene LI, O'Neill KI, Williams MM, Gordon MA, Nemkov T, D'Alessandro A, Degala GD, Shin J, Tan AC, Cittelly DM, Lambert JR, Richer JK. Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression. Mol Cancer Res. 2019 01; 17(1):30-41. PMID: 30213797.
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    312. Stevens BM, Khan N, D'Alessandro A, Nemkov T, Winters A, Jones CL, Zhang W, Pollyea DA, Jordan CT. Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes. Nat Commun. 2018 09 12; 9(1):3694. PMID: 30209285.
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    313. Klarquist J, Chitrakar A, Pennock ND, Kilgore AM, Blain T, Zheng C, Danhorn T, Walton K, Jiang L, Sun J, Hunter CA, D'Alessandro A, Kedl RM. Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis. Sci Immunol. 2018 09 07; 3(27). PMID: 30194241.
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    314. Greene LI, Bruno TC, Christenson JL, D'Alessandro A, Culp-Hill R, Torkko K, Borges VF, Slansky JE, Richer JK. A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma. Mol Cancer Res. 2019 01; 17(1):131-139. PMID: 30143553.
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    315. Catala A, Culp-Hill R, Nemkov T, D'Alessandro A. Quantitative metabolomics comparison of traditional blood draws and TAP capillary blood collection. Metabolomics. 2018 07 12; 14(7):100. PMID: 30830393.
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    316. Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS. Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity. Sci Signal. 2018 07 10; 11(538). PMID: 29991649.
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    317. Zhang C, D'Alessandro A, Wellendorf AM, Mohmoud F, Serrano-Lopez J, Perentesis JP, Komurov K, Alexe G, Stegmaier K, Whitsett JA, Grimes HL, Cancelas JA. KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia. Oncotarget. 2018 Jul 03; 9(51):29665-29679. PMID: 30038712.
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    318. Paukovich N, Xue M, Elder JR, Redzic JS, Blue A, Pike H, Miller BG, Pitts TM, Pollock DD, Hansen K, D'Alessandro A, Eisenmesser EZ. Biliverdin Reductase B Dynamics Are Coupled to Coenzyme Binding. J Mol Biol. 2018 09 14; 430(18 Pt B):3234-3250. PMID: 29932944.
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    319. Haines NR, Manoharan N, Olson JL, D'Alessandro A, Reisz JA. Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal Detachment. J Proteome Res. 2018 07 06; 17(7):2421-2427. PMID: 29877085.
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    320. Banerjee A, Silliman CC, Moore EE, Dzieciatkowska M, Kelher M, Sauaia A, Jones K, Chapman MP, Gonzalez E, Moore HB, D'Alessandro A, Peltz E, Huebner BE, Einerson P, Chandler J, Ghasabayan A, Hansen K. Systemic hyperfibrinolysis after trauma: a pilot study of targeted proteomic analysis of superposed mechanisms in patient plasma. J Trauma Acute Care Surg. 2018 06; 84(6):929-938. PMID: 29554044.
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    321. Faulds KJ, Egelston JN, Sedivy LJ, Mitchell MK, Garimella S, Kozlowski H, D'Alessandro A, Hansen KC, Balsbaugh JL, Phiel CJ. Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells. J Biol Chem. 2018 07 06; 293(27):10731-10743. PMID: 29777057.
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    322. Slaughter AL, Nunns GR, D'Alessandro A, Banerjee A, Hansen KC, Moore EE, Silliman CC, Nemkov T, Moore HB, Fragoso M, Leasia K, Peltz ED. The Metabolopathy of Tissue Injury, Hemorrhagic Shock, and Resuscitation in a Rat Model. Shock. 2018 05; 49(5):580-590. PMID: 28727610.
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    323. Gehrke S, Srinivasan AJ, Culp-Hill R, Reisz JA, Ansari A, Gray A, Landrigan M, Welsby I, D'Alessandro A. Metabolomics evaluation of early-storage red blood cell rejuvenation at 4?C and 37?C. Transfusion. 2018 08; 58(8):1980-1991. PMID: 29687892.
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    324. El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ. Macrophage-derived IL-1?/NF-?B signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018 04 11; 9(1):1393. PMID: 29643332.
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    325. D'Alessandro A, Reisz JA, Culp-Hill R, Korsten H, van Bruggen R, de Korte D. Metabolic effect of alkaline additives and guanosine/gluconate in storage solutions for red blood cells. Transfusion. 2018 08; 58(8):1992-2002. PMID: 29624679.
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    326. Reisz JA, Barrett AS, Nemkov T, Hansen KC, D'Alessandro A. When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies. Expert Rev Proteomics. 2018 04; 15(4):293-309. PMID: 29540077.
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    327. Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D'Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC. Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics. J Biol Chem. 2018 05 04; 293(18):6659-6671. PMID: 29540485.
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    328. Hazegh KE, Nemkov T, D'Alessandro A, Diller JD, Monks J, McManaman JL, Jones KL, Hansen KC, Reis T. Correction: An autonomous metabolic role for Spen. PLoS Genet. 2018 03; 14(3):e1007266. PMID: 29509756.
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    329. Reisz JA, Wither MJ, Moore EE, Slaughter AL, Moore HB, Ghasabyan A, Chandler J, Schaub LJ, Fragoso M, Nunns G, Silliman CC, Hansen KC, Banerjee A, Sheppard FR, D'Alessandro A. All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients. J Trauma Acute Care Surg. 2018 03; 84(3):537-541. PMID: 29112093.
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    330. Perreault L, Newsom SA, Strauss A, Kerege A, Kahn DE, Harrison KA, Snell-Bergeon JK, Nemkov T, D'Alessandro A, Jackman MR, MacLean PS, Bergman BC. Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle. JCI Insight. 2018 02 08; 3(3). PMID: 29415895.
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    331. Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA. OLT1177, a ?-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1530-E1539. PMID: 29378952.
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    332. Friedman JE, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen RC, Soderborg TK, Anderson AL, Reisz JA, D'Alessandro A, Frank DN, Robertson CE, de la Houssaye BA, Johnson LK, Orlicky DJ, Wang XX, Levi M, Potma EO, El Kasmi KC, Jonscher KR. Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice. Hepatol Commun. 2018 03; 2(3):313-328. PMID: 29507905.
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    333. Reisz JA, Tzounakas VL, Nemkov T, Voulgaridou AI, Papassideri IS, Kriebardis AG, D'Alessandro A, Antonelou MH. Metabolic Linkage and Correlations to Storage Capacity in Erythrocytes from Glucose 6-Phosphate Dehydrogenase-Deficient Donors. Front Med (Lausanne). 2017; 4:248. PMID: 29376053.
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    334. Clendenen N, D'Alessandro A. High Throughput Metabolomics in Clinical Studies: Review and New Applications to Remote Ischemic Preconditioning. Curr Top Med Chem. 2018; 18(25):2143-2153. PMID: 30698107.
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    335. Culp-Hill R, Zheng C, Reisz JA, Smith K, Rachubinski A, Nemkov T, Butcher E, Granrath R, Hansen KC, Espinosa JM, D'Alessandro A. Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging. Blood Adv. 2017 Dec 26; 1(27):2776-2780. PMID: 29296929.
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    336. Mitra S, Schiller D, Anderson C, Gamboni F, D'Alessandro A, Kelher M, Silliman CC, Banerjee A, Jones KL. Hypertonic saline attenuates the cytokine-induced pro-inflammatory signature in primary human lung epithelia. PLoS One. 2017; 12(12):e0189536. PMID: 29253007.
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    337. Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 01; 58(1):255-266. PMID: 29243830.
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    338. Culp-Hill R, Reisz JA, Hansen KC, D'Alessandro A. Investigation of the effects of storage and freezing on mixes of heavy-labeled metabolite and amino acid standards. Rapid Commun Mass Spectrom. 2017 Dec 15; 31(23):2030-2034. PMID: 28910859.
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    339. Sun K, D'Alessandro A, Ahmed MH, Zhang Y, Song A, Ko TP, Nemkov T, Reisz JA, Wu H, Adebiyi M, Peng Z, Gong J, Liu H, Huang A, Wen YE, Wen AQ, Berka V, Bogdanov MV, Abdulmalik O, Han L, Tsai AL, Idowu M, Juneja HS, Kellems RE, Dowhan W, Hansen KC, Safo MK, Xia Y. Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease. Sci Rep. 2017 11 10; 7(1):15281. PMID: 29127281.
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    340. Barrett AS, Wither MJ, Hill RC, Dzieciatkowska M, D'Alessandro A, Reisz JA, Hansen KC. Hydroxylamine Chemical Digestion for Insoluble Extracellular Matrix Characterization. J Proteome Res. 2017 11 03; 16(11):4177-4184. PMID: 28971683.
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    341. Nemkov T, Sun K, Reisz JA, Song A, Yoshida T, Dunham A, Wither MJ, Francis RO, Roach RC, Dzieciatkowska M, Rogers SC, Doctor A, Kriebardis A, Antonelou M, Papassideri I, Young CT, Thomas TA, Hansen KC, Spitalnik SL, Xia Y, Zimring JC, Hod EA, D'Alessandro A. Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage. Haematologica. 2018 02; 103(2):361-372. PMID: 29079593.
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    342. Nemkov T, Sun K, Reisz JA, Yoshida T, Dunham A, Wen EY, Wen AQ, Roach RC, Hansen KC, Xia Y, D'Alessandro A. Metabolism of Citrate and Other Carboxylic Acids in Erythrocytes As a Function of Oxygen Saturation and Refrigerated Storage. Front Med (Lausanne). 2017; 4:175. PMID: 29090212.
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    343. D'Alessandro A, Nozik-Grayck E, Stenmark KR. Identification of Infants at Risk for Chronic Lung Disease at Birth. Potential for a Personalized Approach to Disease Prevention. Am J Respir Crit Care Med. 2017 10 15; 196(8):951-952. PMID: 28613077.
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    344. Clendenen N, Nunns GR, Moore EE, Reisz JA, Gonzalez E, Peltz E, Silliman CC, Fragoso M, Nemkov T, Wither MJ, Hansen K, Banerjee A, Moore HB, D'Alessandro A. Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine. J Trauma Acute Care Surg. 2017 10; 83(4):635-642. PMID: 28463938.
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    345. Zhang H, Wang D, Li M, Plecit?-Hlavat? L, D'Alessandro A, Tauber J, Riddle S, Kumar S, Flockton A, McKeon BA, Frid MG, Reisz JA, Caruso P, El Kasmi KC, Je?ek P, Morrell NW, Hu CJ, Stenmark KR. Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis. Circulation. 2017 Dec 19; 136(25):2468-2485. PMID: 28972001.
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    346. Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW. Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2. Circulation. 2017 Dec 19; 136(25):2451-2467. PMID: 28971999.
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    347. Gregory MA, Nemkov T, Reisz JA, Zaberezhnyy V, Hansen KC, D'Alessandro A, DeGregori J. Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol. 2018 02; 58:52-58. PMID: 28947392.
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    348. Gehrke S, Reisz JA, Nemkov T, Hansen KC, D'Alessandro A. Characterization of rapid extraction protocols for high-throughput metabolomics. Rapid Commun Mass Spectrom. 2017 Sep 15; 31(17):1445-1452. PMID: 28586533.
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    349. Henry CJ, Nemkov T, Cas?s-Selves M, Bilousova G, Zaberezhnyy V, Higa KC, Serkova NJ, Hansen KC, D'Alessandro A, DeGregori J. Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis. Haematologica. 2017 12; 102(12):1985-1994. PMID: 28883079.
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    350. Thwe PM, Pelgrom LR, Cooper R, Beauchamp S, Reisz JA, D'Alessandro A, Everts B, Amiel E. Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses. Cell Metab. 2017 Sep 05; 26(3):558-567.e5. PMID: 28877459.
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    351. D'Alessandro A, Moore HB, Moore EE, Reisz JA, Wither MJ, Ghasasbyan A, Chandler J, Silliman CC, Hansen KC, Banerjee A. Plasma succinate is a predictor of mortality in critically injured patients. J Trauma Acute Care Surg. 2017 09; 83(3):491-495. PMID: 28590356.
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    352. Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey AL, Danhorn T, Leach SM, Fingerlin TE, O'Connor BP, Reisz JA, D'Alessandro A, Bratton DL, Jakubzick CV, Janssen WJ. Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury. Am J Respir Cell Mol Biol. 2017 09; 57(3):294-306. PMID: 28421818.
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    353. Reisz JA, D'Alessandro A. Measurement of metabolic fluxes using stable isotope tracers in whole animals and human patients. Curr Opin Clin Nutr Metab Care. 2017 Sep; 20(5):366-374. PMID: 28768294.
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    354. D'Alessandro A, El Kasmi KC, Plecit?-Hlavat? L, Je?ek P, Li M, Zhang H, Gupte SA, Stenmark KR. Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming. Antioxid Redox Signal. 2018 Jan 20; 28(3):230-250. PMID: 28637353.
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    355. Reisz JA, Slaughter AL, Culp-Hill R, Moore EE, Silliman CC, Fragoso M, Peltz ED, Hansen KC, Banerjee A, D'Alessandro A. Red blood cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination in rats. Blood Adv. 2017 Jul 25; 1(17):1296-1305. PMID: 29296771.
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    356. Hazegh KE, Nemkov T, D'Alessandro A, Diller JD, Monks J, McManaman JL, Jones KL, Hansen KC, Reis T. An autonomous metabolic role for Spen. PLoS Genet. 2017 Jun; 13(6):e1006859. PMID: 28640815.
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    357. Sun K, Liu H, Song A, Manalo JM, D'Alessandro A, Hansen KC, Kellems RE, Eltzschig HK, Blackburn MR, Roach RC, Xia Y. Erythrocyte purinergic signaling components underlie hypoxia adaptation. J Appl Physiol (1985). 2017 Oct 01; 123(4):951-956. PMID: 28572494.
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    358. Nemkov T, Hansen KC, D'Alessandro A. A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways. Rapid Commun Mass Spectrom. 2017 Apr 30; 31(8):663-673. PMID: 28195377.
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    359. Sun K, D'alessandro A, Xia Y. Purinergic control of red blood cell metabolism: novel strategies to improve red cell storage quality. Blood Transfus. 2017 Oct; 15(6):535-542. PMID: 28488967.
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    360. D'Alessandro A, Gray AD, Szczepiorkowski ZM, Hansen K, Herschel LH, Dumont LJ. Red blood cell metabolic responses to refrigerated storage, rejuvenation, and frozen storage. Transfusion. 2017 04; 57(4):1019-1030. PMID: 28295356.
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    361. D'Alessandro A, Seghatchian J. Hitchhiker's guide to the red cell storage galaxy: Omics technologies and the quality issue. Transfus Apher Sci. 2017 Apr; 56(2):248-253. PMID: 28343934.
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    362. Clendenen N, Tollefson A, Dzieciatkowska M, Cambiaghi A, Ferrario M, Kroehl M, Banerjee A, D'Alessandro A, Hansen KC, Weitzel N. Correlation of pre-operative plasma protein concentrations in cardiac surgery patients with bleeding outcomes using a targeted quantitative proteomics approach. Proteomics Clin Appl. 2017 07; 11(7-8). PMID: 28176468.
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    363. D'Alessandro A, Dzieciatkowska M, Nemkov T, Hansen KC. Red blood cell proteomics update: is there more to discover? Blood Transfus. 2017 03; 15(2):182-187. PMID: 28263177.
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    364. D'alessandro A, Nemkov T, Reisz J, Dzieciatkowska M, Wither MJ, Hansen KC. Omics markers of the red cell storage lesion and metabolic linkage. Blood Transfus. 2017 Mar; 15(2):137-144. PMID: 28263171.
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    365. D'alessandro A, Liumbruno GM. Red blood cell storage and clinical outcomes: new insights. Blood Transfus. 2017 03; 15(2):101-103. PMID: 28263164.
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    366. Yoshida T, Blair A, D'alessandro A, Nemkov T, Dioguardi M, Silliman CC, Dunham A. Enhancing uniformity and overall quality of red cell concentrate with anaerobic storage. Blood Transfus. 2017 Mar; 15(2):172-181. PMID: 28263176.
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    367. D'Alessandro A, Zolla L. Proteomic analysis of red blood cells and the potential for the clinic: what have we learned so far? Expert Rev Proteomics. 2017 03; 14(3):243-252. PMID: 28162022.
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    368. Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA. Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2313-2318. PMID: 28193888.
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    369. Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017 02 07; 8:14108. PMID: 28169986.
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    370. Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget. 2017 Jan 24; 8(4):6742-6762. PMID: 28039486.
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    371. Reisz JA, Chessler KM, Dzieciatkowska M, D'Alessandro A, Hansen KC. Blood and Plasma Proteomics: Targeted Quantitation and Posttranslational Redox Modifications. Methods Mol Biol. 2017; 1619:353-371. PMID: 28674896.
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    372. Plecit?-Hlavat? L, D'alessandro A, El Kasmi K, Li M, Zhang H, Je?ek P, Stenmark KR. Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension. Adv Exp Med Biol. 2017; 967:241-260. PMID: 29047090.
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    373. D'Alessandro A, Nemkov T, Bogren LK, Martin SL, Hansen KC. Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel. J Proteome Res. 2017 02 03; 16(2):958-969. PMID: 27991798.
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    374. Goddard ET, Hill RC, Nemkov T, D'Alessandro A, Hansen KC, Maller O, Mongoue-Tchokote S, Mori M, Partridge AH, Borges VF, Schedin P. The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis. Cancer Discov. 2017 02; 7(2):177-187. PMID: 27974414.
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    375. Slaughter AL, D'Alessandro A, Moore EE, Banerjee A, Silliman CC, Hansen KC, Reisz JA, Fragoso M, Wither MJ, Bacon AW, Moore HB, Peltz ED. Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock. J Trauma Acute Care Surg. 2016 12; 81(6):1012-1019. PMID: 27602903.
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    376. D'Alessandro A, Nemkov T, Yoshida T, Bordbar A, Palsson BO, Hansen KC. Citrate metabolism in red blood cells stored in additive solution-3. Transfusion. 2017 02; 57(2):325-336. PMID: 27813142.
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    377. Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):E6669-E6678. PMID: 27791036.
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    378. D'Alessandro A, Nemkov T, Sun K, Liu H, Song A, Monte AA, Subudhi AW, Lovering AT, Dvorkin D, Julian CG, Kevil CG, Kolluru GK, Shiva S, Gladwin MT, Xia Y, Hansen KC, Roach RC. AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia. J Proteome Res. 2016 10 07; 15(10):3883-3895. PMID: 27646145.
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    379. Gamboni F, Anderson C, Mitra S, Reisz JA, Nemkov T, Dzieciatkowska M, Jones KL, Hansen KC, D'Alessandro A, Banerjee A. Hypertonic Saline Primes Activation of the p53-p21 Signaling Axis in Human Small Airway Epithelial Cells That Prevents Inflammation Induced by Pro-inflammatory Cytokines. J Proteome Res. 2016 10 07; 15(10):3813-3826. PMID: 27529569.
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    380. Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT. Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells. J Biol Chem. 2016 Oct 14; 291(42):21984-22000. PMID: 27573247.
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    381. Li M, Riddle S, Zhang H, D'Alessandro A, Flockton A, Serkova NJ, Hansen KC, Moldovan R, McKeon BA, Frid M, Kumar S, Li H, Liu H, Ca?novas A, Medrano JF, Thomas MG, Iloska D, Plecit?-Hlavat? L, Je?ek P, Pullamsetti S, Fini MA, El Kasmi KC, Zhang Q, Stenmark KR. Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1. Circulation. 2016 10 11; 134(15):1105-1121. PMID: 27562971.
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    382. Scalea JR, Redfield RR, Arpali E, Leverson GE, Bennett RJ, Anderson ME, Kaufman DB, Fernandez LA, D'Alessandro AM, Foley DP, Mezrich JD. Does DCD Donor Time-to-Death Affect Recipient Outcomes? Implications of Time-to-Death at a High-Volume Center in the United States. Am J Transplant. 2017 01; 17(1):191-200. PMID: 27375072.
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    383. Paglia G, D'Alessandro A, Rolfsson ?, Sigurj?nsson ?E, Bordbar A, Palsson S, Nemkov T, Hansen KC, Gudmundsson S, Palsson BO. Biomarkers defining the metabolic age of red blood cells during cold storage. Blood. 2016 09 29; 128(13):e43-50. PMID: 27554084.
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    384. Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y. Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia. Circulation. 2016 Aug 02; 134(5):405-21. PMID: 27482003.
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    385. D'Alessandro A, Moore HB, Moore EE, Wither MJ, Nemkov T, Morton AP, Gonzalez E, Chapman MP, Fragoso M, Slaughter A, Sauaia A, Silliman CC, Hansen KC, Banerjee A. Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock. Shock. 2016 08; 46(2):173-82. PMID: 26863033.
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    386. Sun K, Zhang Y, D'Alessandro A, Nemkov T, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV, Vila A, O'Brien J, Kellems RE, Dowhan W, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Safo M, Hansen KC, Roach RC, Xia Y. Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia. Nat Commun. 2016 07 15; 7:12086. PMID: 27417539.
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    387. Reisz JA, Wither MJ, Dzieciatkowska M, Nemkov T, Issaian A, Yoshida T, Dunham AJ, Hill RC, Hansen KC, D'Alessandro A. Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells. Blood. 2016 09 22; 128(12):e32-42. PMID: 27405778.
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    388. Plecit?-Hlavat? L, Tauber J, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D'Alessandro A, El Kasmi KC, Je?ek P, Stenmark KR. Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2016 07; 55(1):47-57. PMID: 26699943.
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    389. Tzounakas VL, Kriebardis AG, Georgatzakou HT, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri IS, D'Alessandro A, Antonelou MH. Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors. Data Brief. 2016 Sep; 8:618-27. PMID: 27437434.
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    390. Champagne DP, Hatle KM, Fortner KA, D'Alessandro A, Thornton TM, Yang R, Torralba D, Tom?s-Cort?zar J, Jun YW, Ahn KH, Hansen KC, Haynes L, Anguita J, Rincon M. Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus. Immunity. 2016 06 21; 44(6):1299-311. PMID: 27234056.
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    391. D'alessandro A, Nemkov T, Moore HB, Moore EE, Wither M, Nydam T, Slaughter A, Silliman CC, Banerjee A, Hansen KC. Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph. Blood Transfus. 2016 05; 14(2):185-94. PMID: 27177401.
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    392. Tzounakas VL, Kriebardis AG, Georgatzakou HT, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri IS, D'Alessandro A, Antonelou MH. Glucose 6-phosphate dehydrogenase deficient subjects may be better "storers" than donors of red blood cells. Free Radic Biol Med. 2016 07; 96:152-65. PMID: 27094493.
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    393. Newsom SA, Brozinick JT, Kiseljak-Vassiliades K, Strauss AN, Bacon SD, Kerege AA, Bui HH, Sanders P, Siddall P, Wei T, Thomas M, Kuo MS, Nemkov T, D'Alessandro A, Hansen KC, Perreault L, Bergman BC. Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans. J Appl Physiol (1985). 2016 Jun 01; 120(11):1355-63. PMID: 27032901.
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    394. Goodman SR, Pace BS, Hansen KC, D'alessandro A, Xia Y, Daescu O, Glatt SJ. Minireview: Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: Early steps to precision medicine. Exp Biol Med (Maywood). 2016 Apr; 241(7):772-81. PMID: 27022133.
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    395. D'Alessandro A, Dzieciatkowska M, Hill RC, Hansen KC. Supernatant protein biomarkers of red blood cell storage hemolysis as determined through an absolute quantification proteomics technology. Transfusion. 2016 06; 56(6):1329-39. PMID: 26813021.
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    396. D'alessandro A. Leucoreduction of blood components: clinical and molecular evidence. Blood Transfus. 2016 05; 14(2):212-3. PMID: 26710355.
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    397. Nemkov T, Hansen KC, Dumont LJ, D'Alessandro A. Metabolomics in transfusion medicine. Transfusion. 2016 Apr; 56(4):980-93. PMID: 26662506.
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    398. D'alessandro A, Nemkov T, Hansen KC. Rapid detection of DEHP in packed red blood cells stored under European and US standard conditions. Blood Transfus. 2016 Mar; 14(2):140-4. PMID: 26674826.
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    399. Dumont LJ, D'Alessandro A, Szczepiorkowski ZM, Yoshida T. CO2 -dependent metabolic modulation in red blood cells stored under anaerobic conditions. Transfusion. 2016 Feb; 56(2):392-403. PMID: 26477888.
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    400. Wither M, Dzieciatkowska M, Nemkov T, Strop P, D'Alessandro A, Hansen KC. Hemoglobin oxidation at functional amino acid residues during routine storage of red blood cells. Transfusion. 2016 Feb; 56(2):421-6. PMID: 26426339.
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    401. Moore HB, Moore EE, Chapman MP, Gonzalez E, Slaughter AL, Morton AP, D'Alessandro A, Hansen KC, Sauaia A, Banerjee A, Silliman CC. Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients. J Thromb Haemost. 2015 Oct; 13(10):1878-87. PMID: 26256459.
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    402. D'Amato NC, Rogers TJ, Gordon MA, Greene LI, Cochrane DR, Spoelstra NS, Nemkov TG, D'Alessandro A, Hansen KC, Richer JK. A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer. Cancer Res. 2015 Nov 01; 75(21):4651-64. PMID: 26363006.
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    403. D'Alessandro A, Nemkov T, Hansen KC, Szczepiorkowski ZM, Dumont LJ. Red blood cell storage in additive solution-7 preserves energy and redox metabolism: a metabolomics approach. Transfusion. 2015 Dec; 55(12):2955-66. PMID: 26271632.
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    404. D'Alessandro A, Slaughter AL, Peltz ED, Moore EE, Silliman CC, Wither M, Nemkov T, Bacon AW, Fragoso M, Banerjee A, Hansen KC. Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics. J Transl Med. 2015 Aug 05; 13:253. PMID: 26242576.
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    405. Mosher J, Zhang W, Blumhagen RZ, D'Alessandro A, Nemkov T, Hansen KC, Hesselberth JR, Reis T. Coordination between Drosophila Arc1 and a specific population of brain neurons regulates organismal fat. Dev Biol. 2015 Sep 15; 405(2):280-90. PMID: 26209258.
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    406. Nemkov T, D'Alessandro A, Hansen KC. Three-minute method for amino acid analysis by UHPLC and high-resolution quadrupole orbitrap mass spectrometry. Amino Acids. 2015 Nov; 47(11):2345-57. PMID: 26058356.
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    407. Hill RC, Wither MJ, Nemkov T, Barrett A, D'Alessandro A, Dzieciatkowska M, Hansen KC. Preserved Proteins from Extinct Bison latifrons Identified by Tandem Mass Spectrometry; Hydroxylysine Glycosides are a Common Feature of Ancient Collagen. Mol Cell Proteomics. 2015 Jul; 14(7):1946-58. PMID: 25948757.
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    408. D'Alessandro A, Moore HB, Moore EE, Wither M, Nemkov T, Gonzalez E, Slaughter A, Fragoso M, Hansen KC, Silliman CC, Banerjee A. Early hemorrhage triggers metabolic responses that build up during prolonged shock. Am J Physiol Regul Integr Comp Physiol. 2015 Jun 15; 308(12):R1034-44. PMID: 25876652.
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    409. Taamalli M, D'Alessandro A, Marrocco C, Gevi F, Timperio AM, Zolla L. Proteomic and metabolic profiles of Cakile maritima Scop. Sea Rocket grown in the presence of cadmium. Mol Biosyst. 2015 Apr; 11(4):1096-109. PMID: 25639878.
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    410. Peltz ED, D'Alessandro A, Moore EE, Chin T, Silliman CC, Sauaia A, Hansen KC, Banerjee A. Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury. J Trauma Acute Care Surg. 2015 Apr; 78(4):742-51. PMID: 25807403.
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    411. Hansen KC, D'Alessandro A, Clement CC, Santambrogio L. Lymph formation, composition and circulation: a proteomics perspective. Int Immunol. 2015 May; 27(5):219-27. PMID: 25788586.
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    412. Dzieciatkowska M, D'Alessandro A, Hill RC, Hansen KC. Plasma QconCATs reveal a gender-specific proteomic signature in apheresis platelet plasma supernatants. J Proteomics. 2015 Apr 29; 120:1-6. PMID: 25743772.
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    413. Wiener G, Moore HB, Moore EE, Gonzalez E, Diamond S, Zhu S, D'Alessandro A, Banerjee A. Shock releases bile acid inducing platelet inhibition and fibrinolysis. J Surg Res. 2015 May 15; 195(2):390-5. PMID: 25777826.
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    414. D'Alessandro A, Nemkov T, Kelher M, West FB, Schwindt RK, Banerjee A, Moore EE, Silliman CC, Hansen KC. Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome. Transfusion. 2015 Jun; 55(6):1155-68. PMID: 25556331.
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    415. Cilli D, Mirasole C, Pennisi R, Pallotta V, D'Alessandro A, Antoccia A, Zolla L, Ascenzi P, di Masi A. Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation. PLoS One. 2014; 9(12):e114651. PMID: 25485873.
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    416. D'Alessandro A, Dzieciatkowska M, Peltz ED, Moore EE, Jordan JR, Silliman CC, Banerjee A, Hansen KC. Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry. Shock. 2014 Dec; 42(6):509-17. PMID: 25243424.
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    417. Dzieciatkowska M, D'Alessandro A, Moore EE, Wohlauer M, Banerjee A, Silliman CC, Hansen KC. Lymph is not a plasma ultrafiltrate: a proteomic analysis of injured patients. Shock. 2014 Dec; 42(6):485-498. PMID: 25243428.
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    418. Lana A, Longo V, Dalmasso A, D'Alessandro A, Bottero MT, Zolla L. Omics integrating physical techniques: aged Piedmontese meat analysis. Food Chem. 2015 Apr 01; 172:731-41. PMID: 25442615.
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    419. D'Alessandro A, Amelio I, Berkers CR, Antonov A, Vousden KH, Melino G, Zolla L. Metabolic effect of TAp63a: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense. Oncotarget. 2014 Sep 15; 5(17):7722-33. PMID: 25229745.
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    420. Zolla L, D'alessandro A, Rinalducci S, D'amici GM, Pupella S, Vaglio S, Grazzini G. Classic and alternative red blood cell storage strategies: seven years of "-omics" investigations. Blood Transfus. 2015 Jan; 13(1):21-31. PMID: 25369599.
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    421. D'Alessandro A, Hansen KC, Silliman CC, Moore EE, Kelher M, Banerjee A. Metabolomics of AS-5 RBC supernatants following routine storage. Vox Sang. 2015 Feb; 108(2):131-40. PMID: 25200932.
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    422. Dzieciatkowska M, D'Alessandro A, Burke TA, Kelher MR, Moore EE, Banerjee A, Silliman CC, West BF, Hansen KC. Proteomics of apheresis platelet supernatants during routine storage: Gender-related differences. J Proteomics. 2015 Jan 01; 112:190-209. PMID: 25201077.
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    423. D'Alessandro A, Kriebardis AG, Rinalducci S, Antonelou MH, Hansen KC, Papassideri IS, Zolla L. An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies. Transfusion. 2015 Jan; 55(1):205-19. PMID: 25130459.
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    424. Pallotta V, Gevi F, D'alessandro A, Zolla L. Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview. Blood Transfus. 2014 Jul; 12(3):376-87. PMID: 25074788.
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    425. Pallotta V, Naro F, Gevi F, D'Alessandro A, Zolla L. Supplementation of anti-oxidants in leucofiltered erythrocyte concentrates: assessment of morphological changes through scanning electron microscopy. Blood Transfus. 2014 Jul; 12(3):421-4. PMID: 25074789.
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    426. Cialfi S, Palermo R, Manca S, De Blasio C, Vargas Romero P, Checquolo S, Bellavia D, Uccelletti D, Saliola M, D'Alessandro A, Zolla L, Gulino A, Screpanti I, Talora C. Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis. Cell Cycle. 2014; 13(13):2046-55. PMID: 24801890.
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    427. Prudent M, D'Alessandro A, Cazenave JP, Devine DV, Gachet C, Greinacher A, Lion N, Schubert P, Steil L, Thiele T, Tissot JD, V?lker U, Zolla L. Proteome changes in platelets after pathogen inactivation--an interlaboratory consensus. Transfus Med Rev. 2014 Apr; 28(2):72-83. PMID: 24685438.
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    428. D'Alessandro A, Cervia D, Catalani E, Gevi F, Zolla L, Casini G. Protective effects of the neuropeptides PACAP, substance P and the somatostatin analogue octreotide in retinal ischemia: a metabolomic analysis. Mol Biosyst. 2014 Jun; 10(6):1290-304. PMID: 24514073.
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    429. Olivieri O, Cecconi D, Castagna A, Chiecchi L, Guarini P, Gunasekaran M, Morandini F, Brazzarola P, Zolla L, D'Alessandro A, Veglio F, Mulatero P, Pizzolo F. Urinary protease inhibitor Serpin B3 is higher in women and is further increased in female patients affected by aldosterone producing adenoma. Mol Biosyst. 2014 Jun; 10(6):1281-9. PMID: 24503858.
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    430. D'Alessandro A, Taamalli M, Gevi F, Timperio AM, Zolla L, Ghnaya T. Cadmium stress responses in Brassica juncea: hints from proteomics and metabolomics. J Proteome Res. 2013 Nov 01; 12(11):4979-97. PMID: 24074147.
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    431. D'Alessandro A, Zolla L. Proteomics and metabolomics in cancer drug development. Expert Rev Proteomics. 2013 Oct; 10(5):473-88. PMID: 24117204.
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    432. D'Alessandro A, Marrocco C, Rinalducci S, Peschiaroli A, Timperio AM, Bongiorno-Borbone L, Finazzi Agr? A, Melino G, Zolla L. Analysis of TAp73-dependent signaling via omics technologies. J Proteome Res. 2013 Sep 06; 12(9):4207-20. PMID: 23919926.
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    433. Pallotta V, D'Alessandro A, Rinalducci S, Zolla L. Native protein complexes in the cytoplasm of red blood cells. J Proteome Res. 2013 Jul 05; 12(7):3529-46. PMID: 23781972.
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    434. Longo V, D'alessandro A, Zolla L. Deoxygenation of leucofiltered erythrocyte concentrates preserves proteome stability during storage in the blood bank. Blood Transfus. 2014 Oct; 12(4):599-604. PMID: 24960654.
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    435. Zolla L, D'Alessandro A, Pargui?a AF, Garc?a ?. In reply to: "Further comments on platelet proteomics in Transfusion Medicine". Blood Transfus. 2014 Jan; 12 Suppl 1:s246. PMID: 23867174.
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    436. D'Alessandro A, Mirasole C, Zolla L. Haemoglobin glycation (Hb1Ac) increases during red blood cell storage: a MALDI-TOF mass-spectrometry-based investigation. Vox Sang. 2013 Aug; 105(2):177-80. PMID: 23521396.
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    437. Zolla L, D'Alessandro A. An efficient apparatus for rapid deoxygenation of erythrocyte concentrates for alternative banking strategies. J Blood Transfus. 2013; 2013:896537. PMID: 24066261.
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    438. D'Alessandro A, Gevi F, Zolla L. Red blood cell metabolism under prolonged anaerobic storage. Mol Biosyst. 2013 Jun; 9(6):1196-209. PMID: 23426130.
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    439. Marrocco C, D'Alessandro A, Girelli G, Zolla L. Proteomic analysis of platelets treated with gamma irradiation versus a commercial photochemical pathogen reduction technology. Transfusion. 2013 Aug; 53(8):1808-20. PMID: 23305084.
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    440. Zolla L, D'alessandro A. Response to "Platelets proteomics in transfusion medicine: a reality with challenging but promising future". Blood Transfus. 2013 Apr; 11(2):316. PMID: 23245716.
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    441. D'Alessandro A, Zolla L. Meat science: From proteomics to integrated omics towards system biology. J Proteomics. 2013 Jan 14; 78:558-77. PMID: 23137709.
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    442. Zolla L, D'Alessandro A. Preface to the Special Issue: Integrated omics. J Proteomics. 2012 Dec 05; 76 Spec No.:3-9. PMID: 23079073.
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    443. Polati R, Castagna A, Bossi AM, Alberio T, De Domenico I, Kaplan J, Timperio AM, Zolla L, Gevi F, D'Alessandro A, Brunch R, Olivieri O, Girelli D. Murine macrophages response to iron. J Proteomics. 2012 Dec 05; 76 Spec No.:10-27. PMID: 22835775.
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    444. D'Alessandro A, Blasi B, D'Amici GM, Marrocco C, Zolla L. Red blood cell subpopulations in freshly drawn blood: application of proteomics and metabolomics to a decades-long biological issue. Blood Transfus. 2013 Jan; 11(1):75-87. PMID: 22871816.
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    445. Zolla L, D'Alessandro A. Shaking hands with the future through omics application in transfusion medicine and clinical biochemistry. Blood Transfus. 2012 May; 10 Suppl 2:s1-3. PMID: 22890259.
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    446. D'Alessandro A, Giardina B, Gevi F, Timperio AM, Zolla L. Clinical metabolomics: the next stage of clinical biochemistry. Blood Transfus. 2012 May; 10 Suppl 2:s19-24. PMID: 22890264.
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    447. D'Amici GM, Mirasole C, D'Alessandro A, Yoshida T, Dumont LJ, Zolla L. Red blood cell storage in SAGM and AS3: a comparison through the membrane two-dimensional electrophoresis proteome. Blood Transfus. 2012 May; 10 Suppl 2:s46-54. PMID: 22890268.
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    448. Marrocco C, Pallotta V, D'alessandro A, Alves G, Zolla L. Red blood cell populations and membrane levels of peroxiredoxin 2 as candidate biomarkers to reveal blood doping. Blood Transfus. 2012 May; 10 Suppl 2:s71-7. PMID: 22890272.
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    449. D'Alessandro A, Marrocco C, Rinalducci S, Mirasole C, Failla S, Zolla L. Chianina beef tenderness investigated through integrated Omics. J Proteomics. 2012 Jul 19; 75(14):4381-98. PMID: 22510581.
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    450. Blasi B, D'Amici GM, D'Alessandro A, Zolla L. Native analysis of plasma-derived clotting factor VIII concentrates: "sponge effect" and contaminants. Electrophoresis. 2012 Apr; 33(8):1292-8. PMID: 22589109.
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    451. Gevi F, D'Alessandro A, Rinalducci S, Zolla L. Alterations of red blood cell metabolome during cold liquid storage of erythrocyte concentrates in CPD-SAGM. J Proteomics. 2012 Dec 05; 76 Spec No.:168-80. PMID: 22465715.
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    452. Pallotta V, D'Amici GM, D'Alessandro A, Rossetti R, Zolla L. Red blood cell processing for cryopreservation: from fresh blood to deglycerolization. Blood Cells Mol Dis. 2012 Apr 15; 48(4):226-32. PMID: 22424604.
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    453. Blasi B, D'Alessandro A, Ramundo N, Zolla L. Red blood cell storage and cell morphology. Transfus Med. 2012 Apr; 22(2):90-6. PMID: 22394111.
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    454. D'Alessandro A, Rinalducci S, Marrocco C, Zolla V, Napolitano F, Zolla L. Love me tender: an Omics window on the bovine meat tenderness network. J Proteomics. 2012 Jul 19; 75(14):4360-80. PMID: 22361340.
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    455. D'Alessandro A, Gevi F, Zolla L. Targeted mass spectrometry-based metabolomic profiling through multiple reaction monitoring of liver and other biological matrices. Methods Mol Biol. 2012; 909:279-94. PMID: 22903722.
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    456. D'Alessandro A, Federica G, Palini S, Bulletti C, Zolla L. A mass spectrometry-based targeted metabolomics strategy of human blastocoele fluid: a promising tool in fertility research. Mol Biosyst. 2012 Apr; 8(4):953-8. PMID: 22020776.
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    457. D'Alessandro A, Zolla L. We are what we eat: food safety and proteomics. J Proteome Res. 2012 Jan 01; 11(1):26-36. PMID: 21992580.
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    458. D'Amici GM, Blasi B, D'Alessandro A, Vaglio S, Zolla L. Plasma-derived clotting factor VIII: heterogeneity evaluation in the quest for potential inhibitory-antibody stimulating factors. Electrophoresis. 2011 Nov; 32(21):2941-50. PMID: 21997645.
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    459. D'Alessandro A, D'Amici GM, Vaglio S, Zolla L. Time-course investigation of SAGM-stored leukocyte-filtered red bood cell concentrates: from metabolism to proteomics. Haematologica. 2012 Jan; 97(1):107-15. PMID: 21993682.
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    460. D'Alessandro A, Zolla L. Metabolomics and cancer drug discovery: let the cells do the talking. Drug Discov Today. 2012 Jan; 17(1-2):3-9. PMID: 22001601.
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    461. D'Alessandro A, Marrocco C, Zolla V, D'Andrea M, Zolla L. Meat quality of the longissimus lumborum muscle of Casertana and Large White pigs: metabolomics and proteomics intertwined. J Proteomics. 2011 Dec 21; 75(2):610-27. PMID: 21920477.
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    462. Timperio AM, D'Alessandro A, Fagioni M, Magro P, Zolla L. Production of the phytoalexins trans-resveratrol and delta-viniferin in two economy-relevant grape cultivars upon infection with Botrytis cinerea in field conditions. Plant Physiol Biochem. 2012 Jan; 50(1):65-71. PMID: 21821423.
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    463. D'Alessandro A, D'Amici GM, Timperio AM, Merendino N, Zolla L. Docosohaexanoic acid-supplemented PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomic, metabolomic and interactomic overview. J Proteomics. 2011 Sep 06; 74(10):2138-58. PMID: 21723426.
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    464. D'Alessandro A, Zolla L. The SODyssey: superoxide dismutases from biochemistry, through proteomics, to oxidative stress, aging and nutraceuticals. Expert Rev Proteomics. 2011 Jun; 8(3):405-21. PMID: 21679120.
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    465. Basco D, Nicchia GP, D'Alessandro A, Zolla L, Svelto M, Frigeri A. Absence of aquaporin-4 in skeletal muscle alters proteins involved in bioenergetic pathways and calcium handling. PLoS One. 2011 Apr 28; 6(4):e19225. PMID: 21552523.
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    466. Musat AI, Agni RM, Wai PY, Pirsch JD, Lorentzen DF, Powell A, Leverson GE, Bellingham JM, Fernandez LA, Foley DP, Mezrich JD, D'Alessandro AM, Lucey MR. The significance of donor-specific HLA antibodies in rejection and ductopenia development in ABO compatible liver transplantation. Am J Transplant. 2011 Mar; 11(3):500-10. PMID: 21342448.
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    467. D'Alessandro A, Gevi F, Zolla L. A robust high resolution reversed-phase HPLC strategy to investigate various metabolic species in different biological models. Mol Biosyst. 2011 Apr; 7(4):1024-32. PMID: 21258747.
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    468. D'Alessandro A, Rinalducci S, Zolla L. Redox proteomics and drug development. J Proteomics. 2011 Nov 18; 74(12):2575-95. PMID: 21241836.
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    469. D'Alessandro A, Grazzini G, Giardina B, Zolla L. In silico analyses of proteomic data suggest a role for heat shock proteins in umbilical cord blood hematopoietic stem cells. Stem Cell Rev Rep. 2010 Dec; 6(4):532-47. PMID: 20697978.
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    470. Murgiano L, D'Alessandro A, Egidi MG, Cris? A, Prosperini G, Timperio AM, Valentini A, Zolla L. Proteomics and transcriptomics investigation on longissimus muscles in Large White and Casertana pig breeds. J Proteome Res. 2010 Dec 03; 9(12):6450-66. PMID: 20968299.
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    471. D'Alessandro A, Zolla L. Pharmacoproteomics: a chess game on a protein field. Drug Discov Today. 2010 Dec; 15(23-24):1015-23. PMID: 20969973.
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    472. D'Alessandro A, Zolla L, Scaloni A. The bovine milk proteome: cherishing, nourishing and fostering molecular complexity. An interactomics and functional overview. Mol Biosyst. 2011 Mar; 7(3):579-97. PMID: 20877905.
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    473. D'Alessandro A, Scaloni A, Zolla L. Human milk proteins: an interactomics and updated functional overview. J Proteome Res. 2010 Jul 02; 9(7):3339-73. PMID: 20443637.
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    474. Egidi MG, D'Alessandro A, Mandarello G, Zolla L. Troubleshooting in platelet storage temperature and new perspectives through proteomics. Blood Transfus. 2010 Jun; 8 Suppl 3:s73-81. PMID: 20606754.
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    475. D'Alessandro A, Zolla L. Proteomics for quality-control processes in transfusion medicine. Anal Bioanal Chem. 2010 Sep; 398(1):111-24. PMID: 20496175.
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    476. D'Alessandro A, Liumbruno G, Grazzini G, Zolla L. Red blood cell storage: the story so far. Blood Transfus. 2010 Apr; 8(2):82-8. PMID: 20383300.
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    477. Liumbruno G, D'Alessandro A, Grazzini G, Zolla L. How has proteomics informed transfusion biology so far? Crit Rev Oncol Hematol. 2010 Dec; 76(3):153-72. PMID: 20117018.
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    478. D'Alessandro A, Righetti PG, Fasoli E, Zolla L. The egg white and yolk interactomes as gleaned from extensive proteomic data. J Proteomics. 2010 Mar 10; 73(5):1028-42. PMID: 20080220.
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    479. D'Alessandro A, Righetti PG, Zolla L. The red blood cell proteome and interactome: an update. J Proteome Res. 2010 Jan; 9(1):144-63. PMID: 19886704.
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    480. Liumbruno GM, D'Alessandro A, Rea F, Piccinini V, Catalano L, Calizzani G, Pupella S, Grazzini G. The role of antenatal immunoprophylaxis in the prevention of maternal-foetal anti-Rh(D) alloimmunisation. Blood Transfus. 2010 Jan; 8(1):8-16. PMID: 20104273.
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    481. Bellingham JM, Anderson ME, D'Alessandro AM. Successful kidney transplantation from a donation after cardiac death donor with an ileal conduit. Transplant Proc. 2009 Dec; 41(10):4420-1. PMID: 20005413.
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    482. Timperio AM, D'Alessandro A, Pariset L, D'Amici GM, Valentini A, Zolla L. Comparative proteomics and transcriptomics analyses of livers from two different Bos taurus breeds: "Chianina and Holstein Friesian". J Proteomics. 2009 Dec 01; 73(2):309-22. PMID: 19782776.
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    483. Liumbruno G, D'Alessandro A, Grazzini G, Zolla L. Blood-related proteomics. J Proteomics. 2010 Jan 03; 73(3):483-507. PMID: 19567275.
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    484. D'Alessandro A, Liumbruno G, Grazzini G, Pupella S, Lombardini L, Zolla L. Umbilical cord blood stem cells: towards a proteomic approach. J Proteomics. 2010 Jan 03; 73(3):468-82. PMID: 19559108.
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    485. Yagci G, Fernandez LA, Knechtle SJ, D'Alessandro AM, Chin LT, Musat AI, Lucey MR, Said A, Pirsch JD, Leverson G, Kalayoglu M. The impact of donor variables on the outcome of orthotopic liver transplantation for hepatitis C. Transplant Proc. 2008 Jan-Feb; 40(1):219-23. PMID: 18261591.
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    486. Bernat JL, D'Alessandro AM, Port FK, Bleck TP, Heard SO, Medina J, Rosenbaum SH, Devita MA, Gaston RS, Merion RM, Barr ML, Marks WH, Nathan H, O'connor K, Rudow DL, Leichtman AB, Schwab P, Ascher NL, Metzger RA, Mc Bride V, Graham W, Wagner D, Warren J, Delmonico FL. Report of a National Conference on Donation after cardiac death. Am J Transplant. 2006 Feb; 6(2):281-91. PMID: 16426312.
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    487. Boccellino M, Giuberti G, Quagliuolo L, Marra M, D'Alessandro AM, Fujita H, Giovane A, Abbruzzese A, Caraglia M. Apoptosis induced by interferon-alpha and antagonized by EGF is regulated by caspase-3-mediated cleavage of gelsolin in human epidermoid cancer cells. J Cell Physiol. 2004 Oct; 201(1):71-83. PMID: 15281090.
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    488. Caraglia M, Marra M, Giuberti G, D'Alessandro AM, Baldi A, Tassone P, Venuta S, Tagliaferri P, Abbruzzese A. The eukaryotic initiation factor 5A is involved in the regulation of proliferation and apoptosis induced by interferon-alpha and EGF in human cancer cells. J Biochem. 2003 Jun; 133(6):757-65. PMID: 12869532.
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    489. Del Prete S, Caraglia M, Russo D, Vitale G, Giuberti G, Marra M, D'Alessandro AM, Lupoli G, Addeo R, Facchini G, Rossiello R, Abbruzzese A, Capasso E. Percutaneous ethanol injection efficacy in the treatment of large symptomatic thyroid cystic nodules: ten-year follow-up of a large series. Thyroid. 2002 Sep; 12(9):815-21. PMID: 12481948.
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    490. Cho CS, Knechtle SJ, Heisey DM, Hermina M, Armbrust M, D'Alessandro AM, Musat AI, Kalayoglu M. Analysis of tumor characteristics and survival in liver transplant recipients with incidentally diagnosed hepatocellular carcinoma. J Gastrointest Surg. 2001 Nov-Dec; 5(6):594-601; discussion 601-2. PMID: 12086897.
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    491. Shames BD, D'Alessandro AM, Pirsch JD, Knechtle SJ, Odorico JS, Becker YT, Kalayoglu M, Chin LT, Sollinger HW. Living-unrelated renal transplantation at the University of Wisconsin. Clin Transpl. 2001; 149-56. PMID: 12211777.
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    492. D'alessandro AM, Hoffmann RM, Knechtle SJ, Odorico JS, Becker YT, Musat A, Pirsch JD, Sollinger HW, Kalayoglu M. Liver transplantation from controlled non-heart-beating donors. Surgery. 2000 Oct; 128(4):579-88. PMID: 11015091.
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    493. Rayhill SC, D'Alessandro AM, Odorico JS, Knechtle SJ, Pirsch JD, Heisey DM, Kirk AD, Van der Werf W, Sollinger HW. Simultaneous pancreas-kidney transplantation and living related donor renal transplantation in patients with diabetes: is there a difference in survival? Ann Surg. 2000 Mar; 231(3):417-23. PMID: 10714635.
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    494. Van der Werf WJ, Odorico J, D'Alessandro AM, Knechtle S, Becker Y, Collins B, Pirsch J, Hoffman R, Sollinger HW. Utilization of pediatric donors for pancreas transplantation. Transplant Proc. 1999 Feb-Mar; 31(1-2):610-1. PMID: 10083258.
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    495. Sollinger HW, Odorico JS, Knechtle SJ, D'Alessandro AM, Kalayoglu M, Pirsch JD. Experience with 500 simultaneous pancreas-kidney transplants. Ann Surg. 1998 Sep; 228(3):284-96. PMID: 9742912.
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    496. Van der Werf WJ, D'Alessandro AM, Hoffmann RM, Knechtle SJ. Procurement, preservation, and transport of cadaver kidneys. Surg Clin North Am. 1998 Feb; 78(1):41-54. PMID: 9531934.
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    497. Sher LS, Cosenza CA, Michel J, Makowka L, Miller CM, Schwartz ME, Busuttil R, McDiarmid S, Burdick JF, Klein AS, Esquivel C, Klintmalm G, Levy M, Roberts JP, Lake JR, Kalayoglu M, D'Alessandro AM, Gordon RD, Stieber AC, Shaw BW, Thistlethwaite JR, Whittington P, Wiesner RH, Porayko M, Cosimi AB, et al. Efficacy of tacrolimus as rescue therapy for chronic rejection in orthotopic liver transplantation: a report of the U.S. Multicenter Liver Study Group. Transplantation. 1997 Jul 27; 64(2):258-63. PMID: 9256184.
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    498. Knechtle SJ, Kalayoglu M, D'Alessandro AM, Rikkers LF. Proceed with caution: liver transplantation for metastatic neuroendocrine tumors. Ann Surg. 1997 Apr; 225(4):345-6. PMID: 9114791.
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    499. Ametani MS, D'Alessandro AM, Southard JH. The effect of calcium in the UW solution on preservation of the rat liver. Ann Transplant. 1997; 2(1):34-8. PMID: 9869839.
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    500. Lochhead KM, Pirsch JD, D'Alessandro AM, Knechtle SJ, Kalayoglu M, Sollinger HW, Belzer FO. Risk factors for renal allograft loss in patients with systemic lupus erythematosus. Kidney Int. 1996 Feb; 49(2):512-7. PMID: 8821838.
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    501. Knechtle SJ, D'Alessandro AM, Harms BA, Pirsch JD, Belzer FO, Kalayoglu M. Relationships between sclerosing cholangitis, inflammatory bowel disease, and cancer in patients undergoing liver transplantation. Surgery. 1995 Oct; 118(4):615-9; discussion 619-20. PMID: 7570313.
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    502. D'Alessandro AM, Sollinger HW, Knechtle SJ, Kalayoglu M, Kisken WA, Uehling DT, Moon TD, Messing EM, Bruskewitz RC, Pirsch JD, et al. Living related and unrelated donors for kidney transplantation. A 28-year experience. Ann Surg. 1995 Sep; 222(3):353-62; discussion 362-4. PMID: 7677464.
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    503. Knechtle SJ, Kalayoglu M, D'Alessandro AM, Pirsch JD, Armbrust MJ, Sproat IA, Wojtowycz MM, McDermott JC, Crummy AB, Belzer FO. Portal hypertension: surgical management in the 1990s. Surgery. 1994 Oct; 116(4):687-93; discussion 693-5. PMID: 7940167.
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    504. D'Alessandro AM, Southard JH, Love RB, Belzer FO. Organ preservation. Surg Clin North Am. 1994 Oct; 74(5):1083-95. PMID: 7940062.
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    505. Ploeg RJ, D'Alessandro AM, Hoffmann RM, Eckhoff D, Isaacs R, Knechtle SJ, Pirsch JD, Stegall MD, Kalayoglu M, Belzer FO. Impact of donor factors and preservation on function and survival after liver transplantation. Transplant Proc. 1993 Dec; 25(6):3031-3. PMID: 8266441.
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    506. Sollinger HW, Messing EM, Eckhoff DE, Pirsch JD, D'Alessandro AM, Kalayoglu M, Knechtle SJ, Hickey D, Belzer FO. Urological complications in 210 consecutive simultaneous pancreas-kidney transplants with bladder drainage. Ann Surg. 1993 Oct; 218(4):561-8; discussion 568-70. PMID: 8215647.
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    507. Knechtle SJ, Fleming MF, Barry KL, Steen D, Pirsch JD, D'Alessandro AM, Kalayoglu M, Belzer FO. Liver transplantation in alcoholics: assessment of psychological health and work activity. Transplant Proc. 1993 Apr; 25(2):1916-8. PMID: 8470225.
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    508. Belzer FO, D'Alessandro AM, Hoffmann RM, Knechtle SJ, Reed A, Pirsch JD, Kalayoglu M, Sollinger HW. The use of UW solution in clinical transplantation. A 4-year experience. Ann Surg. 1992 Jun; 215(6):579-83; discussion 584-5. PMID: 1632679.
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    509. Sollinger HW, Knechtle SJ, Reed A, D'Alessandro AM, Kalayoglu M, Belzer FO, Pirsch J. Experience with 100 consecutive simultaneous kidney-pancreas transplants with bladder drainage. Ann Surg. 1991 Dec; 214(6):703-11. PMID: 1741650.
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    510. Perilli V, Sollazzi L, Valenti M, D'Alessandro AM, Lo Monaco M, Pelosi G. [Use of atracurium in patients with muscular diseases. 2 cases of distal and mitochondrial myopathy]. Minerva Anestesiol. 1991 Jul-Aug; 57(7-8):441-4. PMID: 1944970.
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    511. Oratore A, D'Andrea G, D'Alessandro AM, Moreton K, Williams J. Binding and iron delivering of monoferric ovotransferrins to chick-embryo red blood cells (CERBC). Biochem Int. 1990 Oct; 22(1):111-8. PMID: 2282073.
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    512. Pirsch JD, Stratta RJ, Armbrust MJ, D'Alessandro AM, Sollinger HW, Kalayoglu M, Belzer FO. Cadaveric renal transplantation with cyclosporine in patients more than 60 years of age. Transplantation. 1989 Feb; 47(2):259-61. PMID: 2645709.
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    513. Sollinger HW, Stratta RJ, D'Alessandro AM, Kalayoglu M, Pirsch JD, Belzer FO. Experience with simultaneous pancreas-kidney transplantation. Ann Surg. 1988 Oct; 208(4):475-83. PMID: 3052327.
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    514. Kalayoglu M, Sollinger HW, Stratta RJ, D'Alessandro AM, Hoffmann RM, Pirsch JD, Belzer FO. Extended preservation of the liver for clinical transplantation. Lancet. 1988 Mar 19; 1(8586):617-9. PMID: 2894550.
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    515. Salustri A, D'Alessandro AM. [Influence of follicular cells on energy metabolism of oocytes in growing mice]. Boll Soc Ital Biol Sper. 1982 Jul 30; 58(14):900-6. PMID: 7126363.
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