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Angelo D'Alessandro

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

    Collapse Biography 
    Collapse awards and honors
    2017Guest Editor - Special Issue: Red Cell storage and Integrated omics, Blood Transfusion
    2016Research Grant, Linda Crnic Institute for Down Syndrome
    2016Early Career Grant, National Blood Foundation
    2015Scott Murphy Lectureship, BEST 2015
    2013Guest Editor - Special Issue: Integrated Omics, Journal of Proteomics
    2013PhD Thesis publication, Italian National Blood Centre
    2008BEST - Top 50 Italian Academic Graduates, Alma Mater Studiorum Bologne - Presidency of the Italian Republic

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Barrett AS, Wither MJ, Hill RC, Dzieciatkowska M, D'Alessandro A, Reisz JA, Hansen KC. Hydroxylamine Chemical Digestion for Insoluble Extracellular Matrix Characterization. J Proteome Res. 2017 Oct 03. PMID: 28971683.
      View in: PubMed
    2. Clendenen N, Nunns GR, Moore EE, Reisz JA, Gonzalez E, Peltz E, Silliman CC, Fragoso M, Nemkov T, Wither MJ, Hansen K, Banerjee A, Moore HB, D'Alessandro A. Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine. J Trauma Acute Care Surg. 2017 Oct; 83(4):635-642. PMID: 28463938.
      View in: PubMed
    3. Zhang H, Wang D, Li M, Plecitá-Hlavatá L, D'Alessandro A, Tauber J, Riddle S, Kumar S, Flockton AR, McKeon BA, Frid MG, Reisz JA, Caruso P, El Kasmi KC, Ježek P, Morrell NW, Hu CJ, Stenmark KR. The Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension is Regulated through a MiR-124/PTBP1/PKM Axis. Circulation. 2017 Sep 26. PMID: 28972001.
      View in: PubMed
    4. Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos CC, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW. Identification of miR-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 and PKM2. Circulation. 2017 Sep 26. PMID: 28971999.
      View in: PubMed
    5. Gregory MA, Nemkov T, Reisz JA, Zaberezhnyy V, Hansen KC, D'Alessandro A, DeGregori J. Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol. 2017 Sep 22. PMID: 28947392.
      View in: PubMed
    6. Gehrke S, Reisz JA, Nemkov T, Hansen KC, D'Alessandro A. Characterization of rapid extraction protocols for high-throughput metabolomics. Rapid Commun Mass Spectrom. 2017 Sep 15; 31(17):1445-1452. PMID: 28586533.
      View in: PubMed
    7. Culp-Hill R, Reisz JA, Hansen KC, D'Alessandro A. Investigation of the effects of storage and freezing on mixes of heavy-labeled metabolite and amino acid standards. Rapid Commun Mass Spectrom. 2017 Sep 14. PMID: 28910859.
      View in: PubMed
    8. Thwe PM, Pelgrom L, Cooper R, Beauchamp S, Reisz JA, D'Alessandro A, Everts B, Amiel E. Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses. Cell Metab. 2017 Sep 05; 26(3):558-567.e5. PMID: 28877459.
      View in: PubMed
    9. D'Alessandro A, Moore HB, Moore EE, Reisz JA, Wither MJ, Ghasasbyan A, Chandler J, Silliman CC, Hansen KC, Banerjee A. Plasma succinate is a predictor of mortality in critically injured patients. J Trauma Acute Care Surg. 2017 Sep; 83(3):491-495. PMID: 28590356.
      View in: PubMed
    10. Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey AL, Danhorn T, Leach SM, Fingerlin TE, O'Connor BP, Reisz JA, D'Alessandro A, Bratton DL, Jakubzick CV, Janssen WJ. Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury. Am J Respir Cell Mol Biol. 2017 Sep; 57(3):294-306. PMID: 28421818.
      View in: PubMed
    11. D'Alessandro A, El Kasmi KC, Plecitá-Hlavatá L, Ježek P, Li M, Zhang H, Gupte SA, Stenmark KR. Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming. Antioxid Redox Signal. 2017 Aug 14. PMID: 28637353.
      View in: PubMed
    12. D'Alessandro A, Nozik-Grayck E, Stenmark KR. Identification of Infants at Risk for Chronic Lung Disease at Birth: Potential for a Personalized Approach to Disease Prevention. Am J Respir Crit Care Med. 2017 Jun 14. PMID: 28613077.
      View in: PubMed
    13. Nemkov T, Hansen KC, D'Alessandro A. A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways. Rapid Commun Mass Spectrom. 2017 Apr 30; 31(8):663-673. PMID: 28195377.
      View in: PubMed
    14. Sun K, D'alessandro A, Xia Y. Purinergic control of red blood cell metabolism: novel strategies to improve red cell storage quality. Blood Transfus. 2017 Apr 12; 1-8. PMID: 28488967.
      View in: PubMed
    15. D'Alessandro A, Gray AD, Szczepiorkowski ZM, Hansen K, Herschel LH, Dumont LJ. Red blood cell metabolic responses to refrigerated storage, rejuvenation, and frozen storage. Transfusion. 2017 Apr; 57(4):1019-1030. PMID: 28295356.
      View in: PubMed
    16. D'alessandro A, Dzieciatkowska M, Nemkov T, Hansen KC. Red blood cell proteomics update: is there more to discover? Blood Transfus. 2017 Mar; 15(2):182-187. PMID: 28263177.
      View in: PubMed
    17. D'alessandro A, Nemkov T, Reisz J, Dzieciatkowska M, Wither MJ, Hansen KC. Omics markers of the red cell storage lesion and metabolic linkage. Blood Transfus. 2017 Mar; 15(2):137-144. PMID: 28263171.
      View in: PubMed
    18. D'alessandro A, Liumbruno GM. Red blood cell storage and clinical outcomes: new insights. Blood Transfus. 2017 Mar; 15(2):101-103. PMID: 28263164.
      View in: PubMed
    19. Yoshida T, Blair A, D'alessandro A, Nemkov T, Dioguardi M, Silliman CC, Dunham A. Enhancing uniformity and overall quality of red cell concentrate with anaerobic storage. Blood Transfus. 2017 Mar; 15(2):172-181. PMID: 28263176.
      View in: PubMed
    20. D'Alessandro A, Zolla L. Proteomic analysis of red blood cells and the potential for the clinic: what have we learned so far? Expert Rev Proteomics. 2017 Mar; 14(3):243-252. PMID: 28162022.
      View in: PubMed
    21. Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA. Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance. Proc Natl Acad Sci U S A. 2017 Feb 28; 114(9):2313-2318. PMID: 28193888.
      View in: PubMed
    22. Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017 Feb 07; 8:14108. PMID: 28169986.
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    23. Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget. 2017 Jan 24; 8(4):6742-6762. PMID: 28039486.
      View in: PubMed
    24. Reisz JA, Chessler KM, Dzieciatkowska M, D'Alessandro A, Hansen KC. Blood and Plasma Proteomics: Targeted Quantitation and Posttranslational Redox Modifications. Methods Mol Biol. 2017; 1619:353-371. PMID: 28674896.
      View in: PubMed
    25. D'Alessandro A, Nemkov T, Bogren LK, Martin SL, Hansen KC. Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel. J Proteome Res. 2017 Feb 03; 16(2):958-969. PMID: 27991798.
      View in: PubMed
    26. Goddard ET, Hill RC, Nemkov T, D'Alessandro A, Hansen KC, Maller O, Mongoue-Tchokote S, Mori M, Partridge AH, Borges VF, Schedin P. The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis. Cancer Discov. 2017 Feb; 7(2):177-187. PMID: 27974414.
      View in: PubMed
    27. Slaughter AL, D'Alessandro A, Moore EE, Banerjee A, Silliman CC, Hansen KC, Reisz JA, Fragoso M, Wither MJ, Bacon AW, Moore HB, Peltz ED. Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock. J Trauma Acute Care Surg. 2016 Dec; 81(6):1012-1019. PMID: 27602903.
      View in: PubMed
    28. D'Alessandro A, Nemkov T, Yoshida T, Bordbar A, Palsson BO, Hansen KC. Citrate metabolism in red blood cells stored in additive solution-3. Transfusion. 2017 Feb; 57(2):325-336. PMID: 27813142.
      View in: PubMed
    29. Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2016 Oct 25; 113(43):E6669-E6678. PMID: 27791036.
      View in: PubMed
    30. D'Alessandro A, Nemkov T, Sun K, Liu H, Song A, Monte AA, Subudhi AW, Lovering AT, Dvorkin D, Julian CG, Kevil CG, Kolluru GK, Shiva S, Gladwin MT, Xia Y, Hansen KC, Roach RC. AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia. J Proteome Res. 2016 Oct 07; 15(10):3883-3895. PMID: 27646145.
      View in: PubMed
    31. Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT. Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells. J Biol Chem. 2016 Oct 14; 291(42):21984-22000. PMID: 27573247.
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    32. Gamboni F, Anderson C, Mitra S, Reisz JA, Nemkov T, Dzieciatkowska M, Jones KL, Hansen KC, D'Alessandro A, Banerjee A. Hypertonic Saline Primes Activation of the p53-p21 Signaling Axis in Human Small Airway Epithelial Cells That Prevents Inflammation Induced by Pro-inflammatory Cytokines. J Proteome Res. 2016 Oct 07; 15(10):3813-3826. PMID: 27529569.
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    33. Li M, Riddle S, Zhang H, D'Alessandro A, Flockton A, Serkova NJ, Hansen KC, Moldvan R, McKeon BA, Frid M, Kumar S, Li H, Liu H, Caánovas A, Medrano JF, Thomas MG, Iloska D, Plecitá-Hlavatá L, Ježek P, Pullamsetti S, Fini MA, El Kasmi KC, Zhang Q, Stenmark KR. Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1. Circulation. 2016 Oct 11; 134(15):1105-1121. PMID: 27562971.
      View in: PubMed
    34. Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y. Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia. Circulation. 2016 Aug 02; 134(5):405-21. PMID: 27482003.
      View in: PubMed
    35. D'Alessandro A, Moore HB, Moore EE, Wither MJ, Nemkov T, Morton AP, Gonzalez E, Chapman MP, Fragoso M, Slaughter A, Sauaia A, Silliman CC, Hansen KC, Banerjee A. Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock. Shock. 2016 Aug; 46(2):173-82. PMID: 26863033; PMCID: PMC4949141 [Available on 08/01/17].
    36. Sun K, Zhang Y, D'Alessandro A, Nemkov T, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV, Vila A, O'Brien J, Kellems RE, Dowhan W, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Safo M, Hansen KC, Roach RC, Xia Y. Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia. Nat Commun. 2016 Jul 15; 7:12086. PMID: 27417539; PMCID: PMC4947158.
    37. Reisz JA, Wither MJ, Dzieciatkowska M, Nemkov T, Issaian A, Yoshida T, Dunham AJ, Hill RC, Hansen KC, D'Alessandro A. Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells. Blood. 2016 Sep 22; 128(12):e32-42. PMID: 27405778.
      View in: PubMed
    38. Plecitá-Hlavatá L, Tauber J, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D'Alessandro A, El Kasmi KC, Ježek P, Stenmark KR. Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2016 Jul; 55(1):47-57. PMID: 26699943; PMCID: PMC4942204 [Available on 07/01/17].
    39. Tzounakas VL, Kriebardis AG, Georgatzakou HT, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri IS, D'Alessandro A, Antonelou MH. Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors. Data Brief. 2016 Sep; 8:618-27. PMID: 27437434; PMCID: PMC4939423.
    40. Champagne DP, Hatle KM, Fortner KA, D'Alessandro A, Thornton TM, Yang R, Torralba D, Tomás-Cortázar J, Jun YW, Ahn KH, Hansen KC, Haynes L, Anguita J, Rincon M. Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus. Immunity. 2016 Jun 21; 44(6):1299-311. PMID: 27234056; PMCID: PMC4917451 [Available on 06/21/17].
    41. D'alessandro A, Nemkov T, Moore HB, Moore EE, Wither M, Nydam T, Slaughter A, Silliman CC, Banerjee A, Hansen KC. Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph. Blood Transfus. 2016 05; 14(2):185-94. PMID: 27177401; PMCID: PMC4918547.
    42. Tzounakas VL, Kriebardis AG, Georgatzakou HT, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri IS, D'Alessandro A, Antonelou MH. Glucose 6-phosphate dehydrogenase deficient subjects may be better "storers" than donors of red blood cells. Free Radic Biol Med. 2016 Jul; 96:152-65. PMID: 27094493.
      View in: PubMed
    43. Newsom SA, Brozinick JT, Kiseljak-Vassiliades K, Strauss AN, Bacon SD, Kerege AA, Bui HH, Sanders P, Siddall P, Wei T, Thomas M, Kuo MS, Nemkov T, D'Alessandro A, Hansen KC, Perreault L, Bergman BC. Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans. J Appl Physiol (1985). 2016 Jun 01; 120(11):1355-63. PMID: 27032901; PMCID: PMC4891931 [Available on 06/01/17].
    44. Goodman SR, Pace BS, Hansen KC, D'alessandro A, Xia Y, Daescu O, Glatt SJ. Minireview: Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: Early steps to precision medicine. Exp Biol Med (Maywood). 2016 Apr; 241(7):772-81. PMID: 27022133.
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    45. D'Alessandro A, Dzieciatkowska M, Hill RC, Hansen KC. Supernatant protein biomarkers of red blood cell storage hemolysis as determined through an absolute quantification proteomics technology. Transfusion. 2016 Jun; 56(6):1329-39. PMID: 26813021.
      View in: PubMed
    46. D'alessandro A. Leucoreduction of blood components: clinical and molecular evidence. Blood Transfus. 2016 05; 14(2):212-3. PMID: 26710355; PMCID: PMC4918552.
    47. Nemkov T, Hansen KC, Dumont LJ, D'Alessandro A. Metabolomics in transfusion medicine. Transfusion. 2016 Apr; 56(4):980-93. PMID: 26662506.
      View in: PubMed
    48. D'alessandro A, Nemkov T, Hansen KC. Rapid detection of DEHP in packed red blood cells stored under European and US standard conditions. Blood Transfus. 2016 Mar; 14(2):140-4. PMID: 26674826; PMCID: PMC4781781.
    49. Dumont LJ, D'Alessandro A, Szczepiorkowski ZM, Yoshida T. CO2 -dependent metabolic modulation in red blood cells stored under anaerobic conditions. Transfusion. 2016 Feb; 56(2):392-403. PMID: 26477888; PMCID: PMC4752401 [Available on 02/01/17].
    50. Wither M, Dzieciatkowska M, Nemkov T, Strop P, D'Alessandro A, Hansen KC. Hemoglobin oxidation at functional amino acid residues during routine storage of red blood cells. Transfusion. 2016 Feb; 56(2):421-6. PMID: 26426339.
      View in: PubMed
    51. Moore HB, Moore EE, Chapman MP, Gonzalez E, Slaughter AL, Morton AP, D'Alessandro A, Hansen KC, Sauaia A, Banerjee A, Silliman CC. Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients. J Thromb Haemost. 2015 Oct; 13(10):1878-87. PMID: 26256459; PMCID: PMC4838414 [Available on 10/01/16].
    52. D'Amato NC, Rogers TJ, Gordon MA, Greene LI, Cochrane DR, Spoelstra NS, Nemkov TG, D'Alessandro A, Hansen KC, Richer JK. A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer. Cancer Res. 2015 Nov 01; 75(21):4651-64. PMID: 26363006; PMCID: PMC4631670.
    53. D'Alessandro A, Nemkov T, Hansen KC, Szczepiorkowski ZM, Dumont LJ. Red blood cell storage in additive solution-7 preserves energy and redox metabolism: a metabolomics approach. Transfusion. 2015 Dec; 55(12):2955-66. PMID: 26271632.
      View in: PubMed
    54. D'Alessandro A, Slaughter AL, Peltz ED, Moore EE, Silliman CC, Wither M, Nemkov T, Bacon AW, Fragoso M, Banerjee A, Hansen KC. Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics. J Transl Med. 2015 Aug 05; 13:253. PMID: 26242576; PMCID: PMC4523956.
    55. Mosher J, Zhang W, Blumhagen RZ, D'Alessandro A, Nemkov T, Hansen KC, Hesselberth JR, Reis T. Coordination between Drosophila Arc1 and a specific population of brain neurons regulates organismal fat. Dev Biol. 2015 Sep 15; 405(2):280-90. PMID: 26209258; PMCID: PMC4583068.
    56. Nemkov T, D'Alessandro A, Hansen KC. Three-minute method for amino acid analysis by UHPLC and high-resolution quadrupole orbitrap mass spectrometry. Amino Acids. 2015 Nov; 47(11):2345-57. PMID: 26058356; PMCID: PMC4624008 [Available on 11/01/16].
    57. Hill RC, Wither MJ, Nemkov T, Barrett A, D'Alessandro A, Dzieciatkowska M, Hansen KC. Preserved Proteins from Extinct Bison latifrons Identified by Tandem Mass Spectrometry; Hydroxylysine Glycosides are a Common Feature of Ancient Collagen. Mol Cell Proteomics. 2015 Jul; 14(7):1946-58. PMID: 25948757; PMCID: PMC4587324.
    58. D'Alessandro A, Moore HB, Moore EE, Wither M, Nemkov T, Gonzalez E, Slaughter A, Fragoso M, Hansen KC, Silliman CC, Banerjee A. Early hemorrhage triggers metabolic responses that build up during prolonged shock. Am J Physiol Regul Integr Comp Physiol. 2015 Jun 15; 308(12):R1034-44. PMID: 25876652; PMCID: PMC4469929.
    59. Taamalli M, D'Alessandro A, Marrocco C, Gevi F, Timperio AM, Zolla L. Proteomic and metabolic profiles of Cakile maritima Scop. Sea Rocket grown in the presence of cadmium. Mol Biosyst. 2015 Apr; 11(4):1096-109. PMID: 25639878.
      View in: PubMed
    60. Peltz ED, D'Alessandro A, Moore EE, Chin T, Silliman CC, Sauaia A, Hansen KC, Banerjee A. Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury. J Trauma Acute Care Surg. 2015 Apr; 78(4):742-51. PMID: 25807403; PMCID: PMC4375785.
    61. Hansen KC, D'Alessandro A, Clement CC, Santambrogio L. Lymph formation, composition and circulation: a proteomics perspective. Int Immunol. 2015 May; 27(5):219-27. PMID: 25788586.
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    62. Dzieciatkowska M, D'Alessandro A, Hill RC, Hansen KC. Plasma QconCATs reveal a gender-specific proteomic signature in apheresis platelet plasma supernatants. J Proteomics. 2015 Apr 29; 120:1-6. PMID: 25743772.
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    63. Wiener G, Moore HB, Moore EE, Gonzalez E, Diamond S, Zhu S, D'Alessandro A, Banerjee A. Shock releases bile acid inducing platelet inhibition and fibrinolysis. J Surg Res. 2015 May 15; 195(2):390-5. PMID: 25777826; PMCID: PMC4838575.
    64. D'Alessandro A, Nemkov T, Kelher M, West FB, Schwindt RK, Banerjee A, Moore EE, Silliman CC, Hansen KC. Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome. Transfusion. 2015 Jun; 55(6):1155-68. PMID: 25556331; PMCID: PMC4469527.
    65. Cilli D, Mirasole C, Pennisi R, Pallotta V, D'Alessandro A, Antoccia A, Zolla L, Ascenzi P, di Masi A. Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation. PLoS One. 2014; 9(12):e114651. PMID: 25485873; PMCID: PMC4259352.
    66. D'Alessandro A, Dzieciatkowska M, Peltz ED, Moore EE, Jordan JR, Silliman CC, Banerjee A, Hansen KC. Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry. Shock. 2014 Dec; 42(6):509-17. PMID: 25243424; PMCID: PMC4236249.
    67. Lana A, Longo V, Dalmasso A, D'Alessandro A, Bottero MT, Zolla L. Omics integrating physical techniques: aged Piedmontese meat analysis. Food Chem. 2015 Apr 01; 172:731-41. PMID: 25442615.
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    68. D'Alessandro A, Amelio I, Berkers CR, Antonov A, Vousden KH, Melino G, Zolla L. Metabolic effect of TAp63a: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense. Oncotarget. 2014 Sep 15; 5(17):7722-33. PMID: 25229745; PMCID: PMC4202156.
    69. Zolla L, D'alessandro A, Rinalducci S, D'amici GM, Pupella S, Vaglio S, Grazzini G. Classic and alternative red blood cell storage strategies: seven years of "-omics" investigations. Blood Transfus. 2015 Jan; 13(1):21-31. PMID: 25369599; PMCID: PMC4317086.
    70. D'Alessandro A, Hansen KC, Silliman CC, Moore EE, Kelher M, Banerjee A. Metabolomics of AS-5 RBC supernatants following routine storage. Vox Sang. 2015 Feb; 108(2):131-40. PMID: 25200932; PMCID: PMC4393710.
    71. Dzieciatkowska M, D'Alessandro A, Burke TA, Kelher MR, Moore EE, Banerjee A, Silliman CC, West BF, Hansen KC. Proteomics of apheresis platelet supernatants during routine storage: Gender-related differences. J Proteomics. 2015 Jan 01; 112:190-209. PMID: 25201077.
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    72. D'Alessandro A, Kriebardis AG, Rinalducci S, Antonelou MH, Hansen KC, Papassideri IS, Zolla L. An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies. Transfusion. 2015 Jan; 55(1):205-19. PMID: 25130459.
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    73. Pallotta V, Gevi F, D'alessandro A, Zolla L. Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview. Blood Transfus. 2014 Jul; 12(3):376-87. PMID: 25074788; PMCID: PMC4111820.
    74. Pallotta V, Naro F, Gevi F, D'Alessandro A, Zolla L. Supplementation of anti-oxidants in leucofiltered erythrocyte concentrates: assessment of morphological changes through scanning electron microscopy. Blood Transfus. 2014 Jul; 12(3):421-4. PMID: 25074789; PMCID: PMC4111826.
    75. Cialfi S, Palermo R, Manca S, De Blasio C, Vargas Romero P, Checquolo S, Bellavia D, Uccelletti D, Saliola M, D'Alessandro A, Zolla L, Gulino A, Screpanti I, Talora C. Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis. Cell Cycle. 2014; 13(13):2046-55. PMID: 24801890; PMCID: PMC4111696.
    76. Prudent M, D'Alessandro A, Cazenave JP, Devine DV, Gachet C, Greinacher A, Lion N, Schubert P, Steil L, Thiele T, Tissot JD, Völker U, Zolla L. Proteome changes in platelets after pathogen inactivation--an interlaboratory consensus. Transfus Med Rev. 2014 Apr; 28(2):72-83. PMID: 24685438.
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    77. D'Alessandro A, Cervia D, Catalani E, Gevi F, Zolla L, Casini G. Protective effects of the neuropeptides PACAP, substance P and the somatostatin analogue octreotide in retinal ischemia: a metabolomic analysis. Mol Biosyst. 2014 Jun; 10(6):1290-304. PMID: 24514073.
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    78. Olivieri O, Cecconi D, Castagna A, Chiecchi L, Guarini P, Gunasekaran M, Morandini F, Brazzarola P, Zolla L, D'Alessandro A, Veglio F, Mulatero P, Pizzolo F. Urinary protease inhibitor Serpin B3 is higher in women and is further increased in female patients affected by aldosterone producing adenoma. Mol Biosyst. 2014 Jun; 10(6):1281-9. PMID: 24503858.
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    79. D'Alessandro A, Taamalli M, Gevi F, Timperio AM, Zolla L, Ghnaya T. Cadmium stress responses in Brassica juncea: hints from proteomics and metabolomics. J Proteome Res. 2013 Nov 01; 12(11):4979-97. PMID: 24074147.
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    80. D'Alessandro A, Zolla L. Proteomics and metabolomics in cancer drug development. Expert Rev Proteomics. 2013 Oct; 10(5):473-88. PMID: 24117204.
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    81. D'Alessandro A, Marrocco C, Rinalducci S, Peschiaroli A, Timperio AM, Bongiorno-Borbone L, Finazzi Agrò A, Melino G, Zolla L. Analysis of TAp73-dependent signaling via omics technologies. J Proteome Res. 2013 Sep 06; 12(9):4207-20. PMID: 23919926.
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    82. Pallotta V, D'Alessandro A, Rinalducci S, Zolla L. Native protein complexes in the cytoplasm of red blood cells. J Proteome Res. 2013 Jul 05; 12(7):3529-46. PMID: 23781972.
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    83. Longo V, D'alessandro A, Zolla L. Deoxygenation of leucofiltered erythrocyte concentrates preserves proteome stability during storage in the blood bank. Blood Transfus. 2014 Oct; 12(4):599-604. PMID: 24960654; PMCID: PMC4212041.
    84. Zolla L, D'Alessandro A, Parguiña AF, García Á. In reply to: "Further comments on platelet proteomics in Transfusion Medicine". Blood Transfus. 2014 Jan; 12 Suppl 1:s246. PMID: 23867174; PMCID: PMC3934259.
    85. D'Alessandro A, Mirasole C, Zolla L. Haemoglobin glycation (Hb1Ac) increases during red blood cell storage: a MALDI-TOF mass-spectrometry-based investigation. Vox Sang. 2013 Aug; 105(2):177-80. PMID: 23521396.
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    86. Zolla L, D'Alessandro A. An efficient apparatus for rapid deoxygenation of erythrocyte concentrates for alternative banking strategies. J Blood Transfus. 2013; 2013:896537. PMID: 24066261; PMCID: PMC3771128.
    87. D'Alessandro A, Gevi F, Zolla L. Red blood cell metabolism under prolonged anaerobic storage. Mol Biosyst. 2013 Jun; 9(6):1196-209. PMID: 23426130.
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    88. Marrocco C, D'Alessandro A, Girelli G, Zolla L. Proteomic analysis of platelets treated with gamma irradiation versus a commercial photochemical pathogen reduction technology. Transfusion. 2013 Aug; 53(8):1808-20. PMID: 23305084.
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    89. Zolla L, D'alessandro A. Response to "Platelets proteomics in transfusion medicine: a reality with challenging but promising future". Blood Transfus. 2013 Apr; 11(2):316. PMID: 23245716; PMCID: PMC3626488.
    90. D'Alessandro A, Zolla L. Meat science: From proteomics to integrated omics towards system biology. J Proteomics. 2013 Jan 14; 78:558-77. PMID: 23137709.
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    91. Zolla L, D'Alessandro A. Preface to the Special Issue: Integrated omics. J Proteomics. 2012 Dec 05; 76 Spec No.:3-9. PMID: 23079073.
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    92. Polati R, Castagna A, Bossi AM, Alberio T, De Domenico I, Kaplan J, Timperio AM, Zolla L, Gevi F, D'Alessandro A, Brunch R, Olivieri O, Girelli D. Murine macrophages response to iron. J Proteomics. 2012 Dec 05; 76 Spec No.:10-27. PMID: 22835775.
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    93. D'Alessandro A, Blasi B, D'Amici GM, Marrocco C, Zolla L. Red blood cell subpopulations in freshly drawn blood: application of proteomics and metabolomics to a decades-long biological issue. Blood Transfus. 2013 Jan; 11(1):75-87. PMID: 22871816; PMCID: PMC3557492.
    94. Zolla L, D'Alessandro A. Shaking hands with the future through omics application in transfusion medicine and clinical biochemistry. Blood Transfus. 2012 May; 10 Suppl 2:s1-3. PMID: 22890259; PMCID: PMC3418614.
    95. D'Alessandro A, Giardina B, Gevi F, Timperio AM, Zolla L. Clinical metabolomics: the next stage of clinical biochemistry. Blood Transfus. 2012 May; 10 Suppl 2:s19-24. PMID: 22890264; PMCID: PMC3418628.
    96. D'Amici GM, Mirasole C, D'Alessandro A, Yoshida T, Dumont LJ, Zolla L. Red blood cell storage in SAGM and AS3: a comparison through the membrane two-dimensional electrophoresis proteome. Blood Transfus. 2012 May; 10 Suppl 2:s46-54. PMID: 22890268; PMCID: PMC3418620.
    97. Marrocco C, Pallotta V, D'alessandro A, Alves G, Zolla L. Red blood cell populations and membrane levels of peroxiredoxin 2 as candidate biomarkers to reveal blood doping. Blood Transfus. 2012 May; 10 Suppl 2:s71-7. PMID: 22890272; PMCID: PMC3418622.
    98. D'Alessandro A, Marrocco C, Rinalducci S, Mirasole C, Failla S, Zolla L. Chianina beef tenderness investigated through integrated Omics. J Proteomics. 2012 Jul 19; 75(14):4381-98. PMID: 22510581.
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    99. Blasi B, D'Amici GM, D'Alessandro A, Zolla L. Native analysis of plasma-derived clotting factor VIII concentrates: "sponge effect" and contaminants. Electrophoresis. 2012 Apr; 33(8):1292-8. PMID: 22589109.
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    100. Gevi F, D'Alessandro A, Rinalducci S, Zolla L. Alterations of red blood cell metabolome during cold liquid storage of erythrocyte concentrates in CPD-SAGM. J Proteomics. 2012 Dec 05; 76 Spec No.:168-80. PMID: 22465715.
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    101. Pallotta V, D'Amici GM, D'Alessandro A, Rossetti R, Zolla L. Red blood cell processing for cryopreservation: from fresh blood to deglycerolization. Blood Cells Mol Dis. 2012 Apr 15; 48(4):226-32. PMID: 22424604.
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    102. Blasi B, D'Alessandro A, Ramundo N, Zolla L. Red blood cell storage and cell morphology. Transfus Med. 2012 Apr; 22(2):90-6. PMID: 22394111.
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    103. D'Alessandro A, Rinalducci S, Marrocco C, Zolla V, Napolitano F, Zolla L. Love me tender: an Omics window on the bovine meat tenderness network. J Proteomics. 2012 Jul 19; 75(14):4360-80. PMID: 22361340.
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    104. D'Alessandro A, Gevi F, Zolla L. Targeted mass spectrometry-based metabolomic profiling through multiple reaction monitoring of liver and other biological matrices. Methods Mol Biol. 2012; 909:279-94. PMID: 22903722.
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    105. D'Alessandro A, Federica G, Palini S, Bulletti C, Zolla L. A mass spectrometry-based targeted metabolomics strategy of human blastocoele fluid: a promising tool in fertility research. Mol Biosyst. 2012 Apr; 8(4):953-8. PMID: 22020776.
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    106. D'Alessandro A, Zolla L. We are what we eat: food safety and proteomics. J Proteome Res. 2012 Jan 01; 11(1):26-36. PMID: 21992580.
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    107. D'Amici GM, Blasi B, D'Alessandro A, Vaglio S, Zolla L. Plasma-derived clotting factor VIII: heterogeneity evaluation in the quest for potential inhibitory-antibody stimulating factors. Electrophoresis. 2011 Nov; 32(21):2941-50. PMID: 21997645.
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    108. D'Alessandro A, D'Amici GM, Vaglio S, Zolla L. Time-course investigation of SAGM-stored leukocyte-filtered red bood cell concentrates: from metabolism to proteomics. Haematologica. 2012 Jan; 97(1):107-15. PMID: 21993682; PMCID: PMC3248938.
    109. D'Alessandro A, Zolla L. Metabolomics and cancer drug discovery: let the cells do the talking. Drug Discov Today. 2012 Jan; 17(1-2):3-9. PMID: 22001601.
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    110. D'Alessandro A, Marrocco C, Zolla V, D'Andrea M, Zolla L. Meat quality of the longissimus lumborum muscle of Casertana and Large White pigs: metabolomics and proteomics intertwined. J Proteomics. 2011 Dec 21; 75(2):610-27. PMID: 21920477.
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    111. Timperio AM, D'Alessandro A, Fagioni M, Magro P, Zolla L. Production of the phytoalexins trans-resveratrol and delta-viniferin in two economy-relevant grape cultivars upon infection with Botrytis cinerea in field conditions. Plant Physiol Biochem. 2012 Jan; 50(1):65-71. PMID: 21821423.
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    112. D'Alessandro A, D'Amici GM, Timperio AM, Merendino N, Zolla L. Docosohaexanoic acid-supplemented PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomic, metabolomic and interactomic overview. J Proteomics. 2011 Sep 06; 74(10):2138-58. PMID: 21723426.
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    113. D'Alessandro A, Zolla L. The SODyssey: superoxide dismutases from biochemistry, through proteomics, to oxidative stress, aging and nutraceuticals. Expert Rev Proteomics. 2011 Jun; 8(3):405-21. PMID: 21679120.
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    114. Basco D, Nicchia GP, D'Alessandro A, Zolla L, Svelto M, Frigeri A. Absence of aquaporin-4 in skeletal muscle alters proteins involved in bioenergetic pathways and calcium handling. PLoS One. 2011 Apr 28; 6(4):e19225. PMID: 21552523; PMCID: PMC3084271.
    115. D'Alessandro A, Gevi F, Zolla L. A robust high resolution reversed-phase HPLC strategy to investigate various metabolic species in different biological models. Mol Biosyst. 2011 Apr; 7(4):1024-32. PMID: 21258747.
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    116. D'Alessandro A, Rinalducci S, Zolla L. Redox proteomics and drug development. J Proteomics. 2011 Nov 18; 74(12):2575-95. PMID: 21241836.
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    117. D'Alessandro A, Grazzini G, Giardina B, Zolla L. In silico analyses of proteomic data suggest a role for heat shock proteins in umbilical cord blood hematopoietic stem cells. Stem Cell Rev. 2010 Dec; 6(4):532-47. PMID: 20697978.
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    118. Murgiano L, D'Alessandro A, Egidi MG, Crisà A, Prosperini G, Timperio AM, Valentini A, Zolla L. Proteomics and transcriptomics investigation on longissimus muscles in Large White and Casertana pig breeds. J Proteome Res. 2010 Dec 03; 9(12):6450-66. PMID: 20968299.
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    119. D'Alessandro A, Zolla L. Pharmacoproteomics: a chess game on a protein field. Drug Discov Today. 2010 Dec; 15(23-24):1015-23. PMID: 20969973.
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    120. D'Alessandro A, Zolla L, Scaloni A. The bovine milk proteome: cherishing, nourishing and fostering molecular complexity. An interactomics and functional overview. Mol Biosyst. 2011 Mar; 7(3):579-97. PMID: 20877905.
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    121. D'Alessandro A, Scaloni A, Zolla L. Human milk proteins: an interactomics and updated functional overview. J Proteome Res. 2010 Jul 02; 9(7):3339-73. PMID: 20443637.
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    122. Egidi MG, D'Alessandro A, Mandarello G, Zolla L. Troubleshooting in platelet storage temperature and new perspectives through proteomics. Blood Transfus. 2010 Jun; 8 Suppl 3:s73-81. PMID: 20606754; PMCID: PMC2897204.
    123. D'Alessandro A, Zolla L. Proteomics for quality-control processes in transfusion medicine. Anal Bioanal Chem. 2010 Sep; 398(1):111-24. PMID: 20496175.
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    124. D'Alessandro A, Liumbruno G, Grazzini G, Zolla L. Red blood cell storage: the story so far. Blood Transfus. 2010 Apr; 8(2):82-8. PMID: 20383300; PMCID: PMC2851210.
    125. Liumbruno G, D'Alessandro A, Grazzini G, Zolla L. How has proteomics informed transfusion biology so far? Crit Rev Oncol Hematol. 2010 Dec; 76(3):153-72. PMID: 20117018.
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    126. D'Alessandro A, Righetti PG, Fasoli E, Zolla L. The egg white and yolk interactomes as gleaned from extensive proteomic data. J Proteomics. 2010 Mar 10; 73(5):1028-42. PMID: 20080220.
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    127. D'Alessandro A, Righetti PG, Zolla L. The red blood cell proteome and interactome: an update. J Proteome Res. 2010 Jan; 9(1):144-63. PMID: 19886704.
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    128. Liumbruno GM, D'Alessandro A, Rea F, Piccinini V, Catalano L, Calizzani G, Pupella S, Grazzini G. The role of antenatal immunoprophylaxis in the prevention of maternal-foetal anti-Rh(D) alloimmunisation. Blood Transfus. 2010 Jan; 8(1):8-16. PMID: 20104273; PMCID: PMC2809506.
    129. Timperio AM, D'Alessandro A, Pariset L, D'Amici GM, Valentini A, Zolla L. Comparative proteomics and transcriptomics analyses of livers from two different Bos taurus breeds: "Chianina and Holstein Friesian". J Proteomics. 2009 Dec 01; 73(2):309-22. PMID: 19782776.
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    130. Liumbruno G, D'Alessandro A, Grazzini G, Zolla L. Blood-related proteomics. J Proteomics. 2010 Jan 03; 73(3):483-507. PMID: 19567275.
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    131. D'Alessandro A, Liumbruno G, Grazzini G, Pupella S, Lombardini L, Zolla L. Umbilical cord blood stem cells: towards a proteomic approach. J Proteomics. 2010 Jan 03; 73(3):468-82. PMID: 19559108.
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    132. D'Alessandro AM, Southard JH, Love RB, Belzer FO. Organ preservation. Surg Clin North Am. 1994 Oct; 74(5):1083-95. PMID: 7940062.
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    133. Ploeg RJ, D'Alessandro AM, Hoffmann RM, Eckhoff D, Isaacs R, Knechtle SJ, Pirsch JD, Stegall MD, Kalayoglu M, Belzer FO. Impact of donor factors and preservation on function and survival after liver transplantation. Transplant Proc. 1993 Dec; 25(6):3031-3. PMID: 8266441.
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