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Tamir Kanias

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Pathology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cloutier M, Cognasse F, Yokoyama APH, Hazegh K, Mykhailova O, Brandon-Coatham M, Hamzeh-Cognasse H, Kutner JM, Acker JP, Kanias T. Quality assessment of red blood cell concentrates from blood donors at the extremes of the age spectrum: The BEST collaborative study. Transfusion. 2023 08; 63(8):1506-1518. PMID: 37387566.
      View in: PubMed
    2. Donnenberg AD, Kim-Shapiro DB, Kanias T, Moore LR, Kiss JE, Lee JS, Xiong Z, Wang L, Triulzi DJ, Gladwin MT. Optimizing interpretation of survival studies of fresh and aged transfused biotin-labeled RBCs. Transfusion. 2023 01; 63(1):35-46. PMID: 36494878.
      View in: PubMed
    3. Hazegh K, Fang F, Kelly K, Sinchar D, Wang L, Zuchelkowski BE, Ufelle AC, Esparza O, Davizon-Castillo P, Page GP, Kanias T. Erythrocyte mitogen-activated protein kinases mediate hemolytic events under osmotic and oxidative stress and in hemolytic diseases. Cell Signal. 2022 11; 99:110450. PMID: 36029940.
      View in: PubMed
    4. Fang F, Hazegh K, Mast AE, Triulzi DJ, Spencer BR, Gladwin MT, Busch MP, Kanias T, Page GP. Sex-specific genetic modifiers identified susceptibility of cold stored red blood cells to osmotic hemolysis. BMC Genomics. 2022 Mar 23; 23(1):227. PMID: 35321643.
      View in: PubMed
    5. Roubinian NH, Reese SE, Qiao H, Plimier C, Fang F, Page GP, Cable RG, Custer B, Gladwin MT, Goel R, Harris B, Hendrickson JE, Kanias T, Kleinman S, Mast AE, Sloan SR, Spencer BR, Spitalnik SL, Busch MP, Hod EA. Donor genetic and nongenetic factors affecting red blood cell transfusion effectiveness. JCI Insight. 2022 01 11; 7(1). PMID: 34793330.
      View in: PubMed
    6. Hazegh K, Anawalt BD, Dumont LJ, Kanias T. Toxic masculinity in red blood cell units? Testosterone therapy in blood donors revisited. Transfusion. 2021 11; 61(11):3174-3180. PMID: 34519056.
      View in: PubMed
    7. Page GP, Kanias T, Guo YJ, Lanteri MC, Zhang X, Mast AE, Cable RG, Spencer BR, Kiss JE, Fang F, Endres-Dighe SM, Brambilla D, Nouraie M, Gordeuk VR, Kleinman S, Busch MP, Gladwin MT. Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage. J Clin Invest. 2021 07 01; 131(13). PMID: 34014839.
      View in: PubMed
    8. D'Alessandro A, Fu X, Kanias T, Reisz JA, Culp-Hill R, Guo Y, Gladwin MT, Page G, Kleinman S, Lanteri M, Stone M, Busch MP, Zimring JC. Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity. Haematologica. 2021 05 01; 106(5):1290-1302. PMID: 32241843.
      View in: PubMed
    9. Hazegh K, Fang F, Bravo MD, Tran JQ, Muench MO, Jackman RP, Roubinian N, Bertolone L, D'Alessandro A, Dumont L, Page GP, Kanias T. Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress. Transfusion. 2021 02; 61(2):435-448. PMID: 33146433.
      View in: PubMed
    10. Alexander K, Hazegh K, Fang F, Sinchar D, Kiss JE, Page GP, D'Alessandro A, Kanias T. Testosterone replacement therapy in blood donors modulates erythrocyte metabolism and susceptibility to hemolysis in cold storage. Transfusion. 2021 01; 61(1):108-123. PMID: 33073382.
      View in: PubMed
    11. Blessinger SA, Tran JQ, Jackman RP, Gilfanova R, Rittenhouse J, Gutierrez AG, Heitman JW, Hazegh K, Kanias T, Muench MO. Immunodeficient mice are better for modeling the transfusion of human blood components than wild-type mice. PLoS One. 2020; 15(7):e0237106. PMID: 32735605.
      View in: PubMed
    12. D'Alessandro A, Fu X, Reisz JA, Kanias T, Page GP, Stone M, Kleinman S, Zimring JC, Busch M. Stored RBC metabolism as a function of caffeine levels. Transfusion. 2020 06; 60(6):1197-1211. PMID: 32394461.
      View in: PubMed
    13. Stefanoni D, Fu X, Reisz JA, Kanias T, Nemkov T, Page GP, Dumont L, Roubinian N, Stone M, Kleinman S, Busch M, Zimring JC, D'Alessandro A. Nicotine exposure increases markers of oxidant stress in stored red blood cells from healthy donor volunteers. Transfusion. 2020 06; 60(6):1160-1174. PMID: 32385854.
      View in: PubMed
    14. DeSimone RA, Plimier C, Lee C, Kanias T, Cushing MM, Sachais BS, Kleinman S, Busch MP, Roubinian NH. Additive effects of blood donor smoking and gamma irradiation on outcome measures of red blood cell transfusion. Transfusion. 2020 06; 60(6):1175-1182. PMID: 32358816.
      View in: PubMed
    15. Bertolone L, Roy MK, Hay AM, Morrison EJ, Stefanoni D, Fu X, Kanias T, Kleinman S, Dumont LJ, Stone M, Nemkov T, Busch MP, Zimring JC, D'Alessandro A. Impact of taurine on red blood cell metabolism and implications for blood storage. Transfusion. 2020 06; 60(6):1212-1226. PMID: 32339326.
      View in: PubMed
    16. Hazegh K, Bravo MD, Kamel H, Dumont L, Kanias T. The prevalence and demographic determinants of blood donors receiving testosterone replacement therapy at a large USA blood service organization. Transfusion. 2020 05; 60(5):947-954. PMID: 32176332.
      View in: PubMed
    17. Roubinian NH, Kanias T. Blood donor component-recipient linkages: is there fire where there is smoke? Transfusion. 2019 08; 59(8):2485-2488. PMID: 31374151.
      View in: PubMed
    18. Fang F, Hazegh K, Sinchar D, Guo Y, Page GP, Mast AE, Kleinman S, Busch MP, Kanias T. Sex hormone intake in female blood donors: impact on haemolysis during cold storage and regulation of erythrocyte calcium influx by progesterone. Blood Transfus. 2019 07; 17(4):263-273. PMID: 31385799.
      View in: PubMed
    19. Donnenberg AD, Kanias T, Triulzi DJ, Dennis CJ, Meyer EM, Gladwin M. Improved quantitative detection of biotin-labeled red blood cells by flow cytometry. Transfusion. 2019 08; 59(8):2691-2698. PMID: 31172532.
      View in: PubMed
    20. Kanias T, Busch MP. Diversity in a blood bag: application of omics technologies to inform precision Transfusion Medicine. Blood Transfus. 2019 07; 17(4):258-262. PMID: 31184580.
      View in: PubMed
    21. Donnenberg AD, Kanias T, Triulzi DJ, Dennis CJ, Moore LR, Meyer EM, Sinchar D, Kiss JE, Normolle DP, Gladwin MT. Current good manufacturing practices-compliant manufacture and measurement of biotin-labeled red blood cells. Cytotherapy. 2019 07; 21(7):793-800. PMID: 31097327.
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    22. D'Alessandro A, Reisz JA, Zhang Y, Gehrke S, Alexander K, Kanias T, Triulzi DJ, Donadee C, Barge S, Badlam J, Jain S, Risbano MG, Gladwin MT. Effects of aged stored autologous red blood cells on human plasma metabolome. Blood Adv. 2019 03 26; 3(6):884-896. PMID: 30890545.
      View in: PubMed
    23. Stone M, Keating SM, Kanias T, Lanteri MC, Lebedeva M, Sinchar D, Hampton D, Jakub A, Rychka V, Brewer G, Bakkour S, Gefter N, Murcia K, Page GP, Endres-Dighe S, Bialkowski W, Fu X, Zimring J, Raife TJ, Kleinman S, Gladwin MT, Busch MP. Piloting and implementation of quality assessment and quality control procedures in RBC-Omics: a large multi-center study of red blood cell hemolysis during storage. Transfusion. 2019 01; 59(1):57-66. PMID: 30566231.
      View in: PubMed
    24. Kanias T, Stone M, Page GP, Guo Y, Endres-Dighe SM, Lanteri MC, Spencer BR, Cable RG, Triulzi DJ, Kiss JE, Murphy EL, Kleinman S, Gladwin MT, Busch MP, Mast AE. Frequent blood donations alter susceptibility of red blood cells to storage- and stress-induced hemolysis. Transfusion. 2019 01; 59(1):67-78. PMID: 30474858.
      View in: PubMed
    25. Guo Y, Busch MP, Seielstad M, Endres-Dighe S, Westhoff CM, Keating B, Hoppe C, Bordbar A, Custer B, Butterworth AS, Kanias T, Mast AE, Kleinman S, Lu Y, Page GP. Development and evaluation of a transfusion medicine genome wide genotyping array. Transfusion. 2019 01; 59(1):101-111. PMID: 30456907.
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    26. Lanteri MC, Kanias T, Keating S, Stone M, Guo Y, Page GP, Brambilla DJ, Endres-Dighe SM, Mast AE, Bialkowski W, D'Andrea P, Cable RG, Spencer BR, Triulzi DJ, Murphy EL, Kleinman S, Gladwin MT, Busch MP. Intradonor reproducibility and changes in hemolytic variables during red blood cell storage: results of recall phase of the REDS-III RBC-Omics study. Transfusion. 2019 01; 59(1):79-88. PMID: 30408207.
      View in: PubMed
    27. D'Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo Y, Page G, Gladwin MT, Kleinman S, Lanteri M, Stone M, Busch M, Zimring JC. Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics. Transfusion. 2019 01; 59(1):89-100. PMID: 30353560.
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    28. Raslan R, Shah BN, Zhang X, Kanias T, Han J, Machado RF, Gladwin MT, Gordeuk VR, Saraf SL. Hemolysis and hemolysis-related complications in females vs. males with sickle cell disease. Am J Hematol. 2018 11; 93(11):E376-E380. PMID: 30117177.
      View in: PubMed
    29. Reisz JA, Nemkov T, Dzieciatkowska M, Culp-Hill R, Stefanoni D, Hill RC, Yoshida T, Dunham A, Kanias T, Dumont LJ, Busch M, Eisenmesser EZ, Zimring JC, Hansen KC, D'Alessandro A. Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. Transfusion. 2018 12; 58(12):2978-2991. PMID: 30312994.
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    30. Endres-Dighe SM, Guo Y, Kanias T, Lanteri M, Stone M, Spencer B, Cable RG, Kiss JE, Kleinman S, Gladwin MT, Brambilla DJ, D'Andrea P, Triulzi DJ, Mast AE, Page GP, Busch MP. Blood, sweat, and tears: Red Blood Cell-Omics study objectives, design, and recruitment activities. Transfusion. 2019 01; 59(1):46-56. PMID: 30267427.
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    31. Kanias T, Lanteri MC, Page GP, Guo Y, Endres SM, Stone M, Keating S, Mast AE, Cable RG, Triulzi DJ, Kiss JE, Murphy EL, Kleinman S, Busch MP, Gladwin MT. Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study. Blood Adv. 2017 Jun 27; 1(15):1132-1141. PMID: 29034365.
      View in: PubMed
    32. Kanias T, Sinchar D, Osei-Hwedieh D, Baust JJ, Jordan A, Zimring JC, Waterman HR, de Wolski KS, Acker JP, Gladwin MT. Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease. Transfusion. 2016 Oct; 56(10):2571-2583. PMID: 27507802.
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    33. Osei-Hwedieh DO, Kanias T, Croix CS, Jessup M, Xiong Z, Sinchar D, Franks J, Xu Q, M Novelli E, Sertorio JT, Potoka K, Binder RJ, Basu S, Belanger AM, Kim-Shapiro DB, Triulzi D, Lee JS, Gladwin MT. Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice. EBioMedicine. 2016 Sep; 11:239-248. PMID: 27523807.
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    34. Jordan A, Chen D, Yi QL, Kanias T, Gladwin MT, Acker JP. Assessing the influence of component processing and donor characteristics on quality of red cell concentrates using quality control data. Vox Sang. 2016 Jul; 111(1):8-15. PMID: 26991891.
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    35. Risbano MG, Kanias T, Triulzi D, Donadee C, Barge S, Badlam J, Jain S, Belanger AM, Kim-Shapiro DB, Gladwin MT. Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function. Am J Respir Crit Care Med. 2015 Nov 15; 192(10):1223-33. PMID: 26222884.
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    36. Cort?s-Puch I, Remy KE, Solomon SB, Sun J, Wang D, Al-Hamad M, Kelly SM, Sinchar D, Bellavia L, Kanias T, Popovsky MA, Kim-Shapiro DB, Klein HG, Natanson C. In a canine pneumonia model of exchange transfusion, altering the age but not the volume of older red blood cells markedly alters outcome. Transfusion. 2015 Nov; 55(11):2564-75. PMID: 26469998.
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    37. Saraf SL, Zhang X, Shah B, Kanias T, Gudehithlu KP, Kittles R, Machado RF, Arruda JA, Gladwin MT, Singh AK, Gordeuk VR. Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy. Haematologica. 2015 Oct; 100(10):1275-84. PMID: 26206798.
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    38. Belanger AM, Keggi C, Kanias T, Gladwin MT, Kim-Shapiro DB. Effects of nitric oxide and its congeners on sickle red blood cell deformability. Transfusion. 2015 Oct; 55(10):2464-72. PMID: 25912054.
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    39. Huang S, Hou HW, Kanias T, Sertorio JT, Chen H, Sinchar D, Gladwin MT, Han J. Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage. Lab Chip. 2015 Jan 21; 15(2):448-58. PMID: 25406942.
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    40. Wang D, Cort?s-Puch I, Sun J, Solomon SB, Kanias T, Remy KE, Feng J, Alimchandani M, Quezado M, Helms C, Perlegas A, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia. Transfusion. 2014 Jul; 54(7):1712-24. PMID: 24588210.
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    41. Cort?s-Puch I, Wang D, Sun J, Solomon SB, Remy KE, Fernandez M, Feng J, Kanias T, Bellavia L, Sinchar D, Perlegas A, Solomon MA, Kelley WE, Popovsky MA, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia. Blood. 2014 Feb 27; 123(9):1403-11. PMID: 24366359.
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    42. Saraf SL, Zhang X, Kanias T, Lash JP, Molokie RE, Oza B, Lai C, Rowe JH, Gowhari M, Hassan J, Desimone J, Machado RF, Gladwin MT, Little JA, Gordeuk VR. Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia. Br J Haematol. 2014 Mar; 164(5):729-39. PMID: 24329963.
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    43. Wang D, Piknova B, Solomon SB, Cortes-Puch I, Kern SJ, Sun J, Kanias T, Gladwin MT, Helms C, Kim-Shapiro DB, Schechter AN, Natanson C. In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines. Transfusion. 2013 Dec; 53(12):3149-63. PMID: 23488474.
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    44. Solomon SB, Wang D, Sun J, Kanias T, Feng J, Helms CC, Solomon MA, Alimchandani M, Quezado M, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C. Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood. 2013 Feb 28; 121(9):1663-72. PMID: 23255558.
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    45. Nouraie M, Lee JS, Zhang Y, Kanias T, Zhao X, Xiong Z, Oriss TB, Zeng Q, Kato GJ, Gibbs JS, Hildesheim ME, Sachdev V, Barst RJ, Machado RF, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Goldsmith JC, Gordeuk VR, Gladwin MT. The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica. 2013 Mar; 98(3):464-72. PMID: 22983573.
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    46. Kanias T, Wang L, Lippert A, Kim-Shapiro DB, Gladwin MT. Red blood cell endothelial nitric oxide synthase does not modulate red blood cell storage hemolysis. Transfusion. 2013 May; 53(5):981-9. PMID: 22897637.
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    47. Kanias T, Gladwin MT. Nitric oxide, hemolysis, and the red blood cell storage lesion: interactions between transfusion, donor, and recipient. Transfusion. 2012 Jul; 52(7):1388-92. PMID: 22780890.
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    48. Gladwin MT, Kanias T, Kim-Shapiro DB. Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease. J Clin Invest. 2012 Apr; 122(4):1205-8. PMID: 22446184.
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    49. Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, Zhao X, Liu C, Reynolds H, Azarov I, Frizzell S, Meyer EM, Donnenberg AD, Qu L, Triulzi D, Kim-Shapiro DB, Gladwin MT. Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation. 2011 Jul 26; 124(4):465-76. PMID: 21747051.
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    50. Kanias T, Acker JP. Mechanism of hemoglobin-induced cellular injury in desiccated red blood cells. Free Radic Biol Med. 2010 Aug 15; 49(4):539-47. PMID: 20433918.
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    51. Kanias T, Acker JP. Biopreservation of red blood cells--the struggle with hemoglobin oxidation. FEBS J. 2010 Jan; 277(2):343-56. PMID: 19968714.
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    52. Kanias T, Acker JP. G.B. Quan et al., Inhibition of high glucose-induced erythrocyte phosphatidylserine exposure by leupeptin and disaccharides, Cryobiology 56 (1) (2008) 53-61. Cryobiology. 2009 Apr; 58(2):240. PMID: 19168046.
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    53. Kanias T, Acker JP. Trehalose loading into red blood cells is accompanied with hemoglobin oxidation and membrane lipid peroxidation. Cryobiology. 2009 Apr; 58(2):232-9. PMID: 19135990.
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    54. Levavi-Sivan B, Hedvat R, Kanias T, Francis G, Becker K, Kerem Z. Exposure of tilapia pituitary cells to saponins: insight into their mechanism of action. Comp Biochem Physiol C Toxicol Pharmacol. 2005 Jan; 140(1):79-86. PMID: 15792626.
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