Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Yuki Fujiwara

TitleAsst Professor Adjoint
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-SRG

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yamada H, Yano H, Matsubara E, Zhao S, Shinchi Y, Pan C, Koga T, Fujino K, Fujiwara Y, Ikeda K, Komohara Y, Suzuki M. The expression of PD-1 ligands in the immune microenvironment was altered in TTF-1-negative lung adenocarcinoma. Hum Cell. 2025 Aug 18; 38(5):146. PMID: 40824335.
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    2. Hirao H, Yoshii D, Esumi S, Adawy A, Fujiwara Y, Honda M, Yokouchi Y, Hibi T, Komohara Y. SOX9 Is a Key Factor for the Postnatal Maturation of the Intrahepatic Bile Duct Network. Hepatol Res. 2025 Aug 16. PMID: 40818083.
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    3. Li L, Hirao H, Honda M, Adawy A, Pan C, Fujiwara Y, Yoshii D, Xue W, Tomita M, Su J, Hibi T, Komohara Y. Preventive role of CD163-positive macrophages in postoperative peritoneal adhesions. Inflamm Regen. 2025 Aug 15; 45(1):26. PMID: 40817081.
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    4. Sun Y, Fujiwara Y, Torphy RJ, Yee EJ, Guo Y, Sun Z, Hu J, Eck E, Terai T, Schulick RD, Zhu Y. CD93 blockade overcomes sunitinib resistance in pancreatic neuroendocrine tumors. Mol Ther. 2025 Oct 01; 33(10):5017-5027. PMID: 40739755.
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    5. Tagayasu Y, Yamada R, Kanemitsu K, Kondo Y, Fujiwara Y, Tanizaki T, Itoyama R, Kitano Y, Hayashi H, Komohara Y, Iwatsuki M. Increased Infiltration of Tissue-Resident Memory T Cells Predicts a Good Response to Anti-PD-L1 Immunotherapy in Extrahepatic Cholangiocarcinoma. Pathobiology. 2025 Jul 25; 1-11. PMID: 40716424.
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    6. Saisuwan K, Boonnate P, Goto H, Nakagawa R, Abe M, Hirabayashi K, Fujiwara Y, Kikuta K, Okada S. Establishment and characterization of TK-DDCS1: a novel IDH1 mutated dedifferentiated chondrosarcoma cell line. Hum Cell. 2025 Jun 03; 38(4):116. PMID: 40459681.
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    7. Saito Y, Fujiwara Y, Yamaguchi YL, Tanaka SS, Miura K, Hizukuri Y, Yamashiro K, Hayashi Y, Nakashima Y, Komohara Y. Rodent monocyte-derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians. Dev Dyn. 2025 May 12. PMID: 40355384.
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    8. Fukuda R, Fujiwara Y, Maeda H, Pan C, Minayoshi Y, Yano H, Mizuta Y, Takano M, Yamada R, Saito Y, Hirata K, Imoto S, Yamasaki K, Oniki K, Saruwatari J, Otagiri M, Watanabe H, Komohara Y, Maruyama T. Lymph node macrophage-targeted interferon alpha boosts anticancer immune responses by regulating CD169-positive phenotype of macrophages. Mol Cancer. 2025 May 03; 24(1):132. PMID: 40319320.
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    9. Yokoi M, Murakami K, Yaguchi T, Chamoto K, Ozasa H, Yoshida H, Shirakashi M, Ito K, Komohara Y, Fujiwara Y, Yano H, Ogimoto T, Hira D, Terada T, Hirai T, Tsukamoto H. ICOS+CD4+ T cells define a high susceptibility to anti-PD-1 therapy-induced lung pathogenesis. JCI Insight. 2025 May 22; 10(10). PMID: 40198121.
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    10. Matsuzaki H, Kai K, Komohara Y, Yano H, Pan C, Fujiwara Y, Yamada R, Iwauchi A, Fukasawa N, Tanaka T, Shimoda M, Watanabe H, Maruyama T, Takeo T, Mikami Y, Mukasa A. Abnormal Vessels Potentially Accelerate Glioblastoma Proliferation by Inducing the Protumor Activation of Macrophages. Cancer Sci. 2025 Apr; 116(4):897-909. PMID: 39921277.
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    11. Sun Y, Yee E, Fujiwara Y, Dickinson K, Guo Y, Sun Z, Hu J, Davila E, Schulick RD, Zhu Y. CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors. J Immunother Cancer. 2025 Jan 13; 13(1). PMID: 39805660.
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    12. Yamashita Y, Hosoya K, Fujiwara Y, Saito Y, Yoshida M, Matsune S, Okubo K, Takei T. Injectable Chitosan Hydrogel Particles as Nasal Packing Materials After Endoscopic Sinus Surgery for Treatment of Chronic Sinusitis. Gels. 2025 Jan 11; 11(1). PMID: 39852031.
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    13. Ezaki A, Yano H, Pan C, Fujiwara Y, Anami T, Ibe Y, Ozaki Y, Nishizawa H, Motoshima T, Yatsuda J, Watanabe H, Maruyama T, Takeo T, Kamba T, Komohara Y. Immunohistochemical Analysis of a1-Acid Glycoprotein and Tumor Associated Macrophages in Clear Cell Renal Cell Carcinoma. Cancer Genomics Proteomics. 2025 Jan-Feb; 22(1):103-111. PMID: 39730181.
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    14. Wada T, Senokuchi T, Shi Y, Furusho T, Morita Y, Sarie M, Hanatani S, Fukuda K, Ishii N, Matsumura T, Fujiwara Y, Komohara Y, Araki E, Kubota N. Orally administrated acetate inhibits atherosclerosis progression through AMPK activation via GPR43 in plaque macrophages. Atherosclerosis. 2025 02; 401:119088. PMID: 39705906.
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    15. Nishitsuji K, Mito R, Ikezaki M, Yano H, Fujiwara Y, Matsubara E, Nishikawa T, Ihara Y, Uchimura K, Iwahashi N, Sakagami T, Suzuki M, Komohara Y. Impacts of cytoplasmic p53 aggregates on the prognosis and the transcriptome in lung squamous cell carcinoma. Cancer Sci. 2024 Sep; 115(9):2947-2960. PMID: 39031627.
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    16. Sungwan P, Panaampon J, Kariya R, Kamio S, Nakagawa R, Hirozane T, Ogura Y, Abe M, Hirabayashi K, Fujiwara Y, Kikuta K, Okada S. Establishment and characterization of TK-ALCL1: a novel NPM-ALK-positive anaplastic large-cell lymphoma cell line. Hum Cell. 2024 Jul; 37(4):1215-1225. PMID: 38755432.
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    17. Sonokawa T, Fujiwara Y, Pan C, Komohara Y, Usuda J. Enhanced systemic antitumor efficacy of PD-1/PD-L1 blockade with immunological response induced by photodynamic therapy. Thorac Cancer. 2024 06; 15(18):1429-1436. PMID: 38739102.
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    18. Kanemitsu K, Yamada R, Pan C, Tsukamoto H, Yano H, Shiota T, Fujiwara Y, Miyamoto Y, Mikami Y, Baba H, Komohara Y. Age-associated reduction of sinus macrophages in human mesenteric lymph nodes. J Clin Exp Hematop. 2024 Jun 27; 64(2):79-85. PMID: 38462485.
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    19. Makino K, Ishii T, Takeda H, Saito Y, Fujiwara Y, Fujimoto M, Ito T, Wakama S, Kumagai K, Munekage F, Horie H, Tomofuji K, Oshima Y, Uebayashi EY, Kawai T, Ogiso S, Fukumitsu K, Takai A, Seno H, Hatano E. Integrated analyses of the genetic and clinicopathological features of cholangiolocarcinoma: cholangiolocarcinoma may be characterized by mismatch-repair deficiency. J Pathol. 2024 05; 263(1):32-46. PMID: 38362598.
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    20. Hirao H, Adawy A, Li L, Yoshii D, Yano H, Fujiwara Y, Honda M, Harada M, Yamamoto M, Komohara Y, Hibi T. The expression analysis of SerpinB9 in hepatoblastoma microenvironment. Pediatr Surg Int. 2024 Feb 12; 40(1):55. PMID: 38347163.
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    21. Li L, Kanemitsu K, Ohnishi K, Yamada R, Yano H, Fujiwara Y, Miyamoto Y, Mikami Y, Hibi T, Baba H, Komohara Y. CXCL10 Expression in Human Colorectal Cancer Tissue and its Correlation With Serum Levels of CXCL10. Cancer Genomics Proteomics. 2024 Jan-Feb; 21(1):54-64. PMID: 38151286.
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    22. Takahashi N, Nakashima R, Nasu A, Hayashi M, Fujikawa H, Kawakami T, Eto Y, Kishimoto T, Fukuyama A, Ogasawara C, Kawano K, Fujiwara Y, Suico MA, Kai H, Shuto T. T3 Intratracheal Therapy Alleviates Pulmonary Pathology in an Elastase-Induced Emphysema-Dominant COPD Mouse Model. Antioxidants (Basel). 2023 Dec 22; 13(1). PMID: 38247455.
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    23. Anami T, Ibe Y, Li L, Komohara Y, Hirao H, Harada M, Yano H, Fujiwara Y, Motoshima T, Yatsuda J, Hibi T, Kamba T. Overexpression of SerpinB9 in non-seminomatous germ cell tumors. Med Mol Morphol. 2024 Mar; 57(1):68-75. PMID: 37991604.
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    24. Anami T, Pan C, Fujiwara Y, Komohara Y, Yano H, Saito Y, Sugimoto M, Wakita D, Motoshima T, Murakami Y, Yatsuda J, Takahashi N, Suzu S, Asano K, Tamada K, Kamba T. Dysfunction of sinus macrophages in tumor-bearing host induces resistance to immunotherapy. Cancer Sci. 2024 Jan; 115(1):59-69. PMID: 37923388.
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    25. Adawy A, Li L, Hirao H, Irie T, Yoshii D, Yano H, Fujiwara Y, Esumi S, Honda M, Suzu S, Komohara Y, Hibi T. Potential involvement of IL-32 in cell-to-cell communication between macrophages and hepatoblastoma. Pediatr Surg Int. 2023 Sep 26; 39(1):275. PMID: 37751001.
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    26. Matsubara E, Shinchi Y, Komohara Y, Yano H, Pan C, Fujiwara Y, Ikeda K, Suzuki M. PD-L2 overexpression on tumor-associated macrophages is one of the predictors for better prognosis in lung adenocarcinoma. Med Mol Morphol. 2023 Dec; 56(4):250-256. PMID: 37402054.
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    27. Uchikawa H, Kameno K, Kai K, Kajiwara S, Fujimori K, Uekawa K, Fujiwara Y, Mukasa A, Kim-Mitsuyama S, Hasegawa Y. Pretreatment with Clodronate Improved Neurological Function by Preventing Reduction of Posthemorrhagic Cerebral Blood Flow in Experimental Subarachnoid Hemorrhage. Neurocrit Care. 2023 08; 39(1):207-217. PMID: 37308726.
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    28. Miura Y, Motoshima T, Anami T, Yano H, Mito R, Pan C, Urakami S, Kinowaki K, Tsukamoto H, Kurahashi R, Murakami Y, Yatsuda J, Fujiwara Y, Kamba T, Komohara Y. Predictive value of CXCL10 for the occurrence of immune-related adverse events in patient with renal cell carcinoma. Microbiol Immunol. 2023 Jul; 67(7):345-354. PMID: 36975091.
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    29. Matsubara E, Yano H, Pan C, Komohara Y, Fujiwara Y, Zhao S, Shinchi Y, Kurotaki D, Suzuki M. The Significance of SPP1 in Lung Cancers and Its Impact as a Marker for Protumor Tumor-Associated Macrophages. Cancers (Basel). 2023 Apr 12; 15(8). PMID: 37190178.
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    30. Yamashita Y, Ohzuno Y, Saito Y, Fujiwara Y, Yoshida M, Takei T. Autoclaving-Triggered Hydrogelation of Chitosan-Gluconic acid Conjugate Aqueous Solution for Wound Healing. Gels. 2023 Mar 29; 9(4). PMID: 37102892.
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    31. Mito R, Iriki T, Fujiwara Y, Pan C, Ikeda T, Nohara T, Suzuki M, Sakagami T, Komohara Y. Onionin A inhibits small-cell lung cancer proliferation through suppressing STAT3 activation induced by macrophages-derived IL-6 and cell-cell interaction with tumor-associated macrophage. Hum Cell. 2023 May; 36(3):1068-1080. PMID: 36961655.
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    32. Komohara Y, Kurotaki D, Tsukamoto H, Miyasato Y, Yano H, Pan C, Yamamoto Y, Fujiwara Y. Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes. Cancer Sci. 2023 Jun; 114(6):2220-2229. PMID: 36748310.
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    33. Saito Y, Fujiwara Y, Miyamoto Y, Ohnishi K, Nakashima Y, Tabata Y, Baba H, Komohara Y. CD169+ sinus macrophages in regional lymph nodes do not predict mismatch-repair status of patients with colorectal cancer. Cancer Med. 2023 05; 12(9):10199-10211. PMID: 36846928.
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    34. Ohno Y, Toshino M, Mohammed AFA, Fujiwara Y, Komohara Y, Onodera R, Higashi T, Motoyama K. Mannose-methyl-ß-cyclodextrin suppresses tumor growth by targeting both colon cancer cells and tumor-associated macrophages. Carbohydr Polym. 2023 Apr 01; 305:120551. PMID: 36737200.
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    35. Osa S, Enoki Y, Miyajima T, Akiyama M, Fujiwara Y, Taguchi K, Kim YG, Matsumoto K. SCIATIC DENERVATION-INDUCED SKELETAL MUSCLE ATROPHY IS ASSOCIATED WITH PERSISTENT INFLAMMATION AND INCREASED MORTALITY DURING SEPSIS. Shock. 2023 03 01; 59(3):417-425. PMID: 36427072.
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    36. Matsubara E, Komohara Y, Esumi S, Shinchi Y, Ishizuka S, Mito R, Pan C, Yano H, Kobayashi D, Fujiwara Y, Ikeda K, Sakagami T, Suzuki M. SPP1 Derived from Macrophages Is Associated with a Worse Clinical Course and Chemo-Resistance in Lung Adenocarcinoma. Cancers (Basel). 2022 Sep 08; 14(18). PMID: 36139536.
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    37. Iwahashi N, Ikezaki M, Komohara Y, Fujiwara Y, Noguchi T, Nishioka K, Sakai K, Nishio K, Ueda M, Ihara Y, Uchimura K, Ino K, Nishitsuji K. Cytoplasmic p53 aggregates accumulated in p53-mutated cancer correlate with poor prognosis. PNAS Nexus. 2022 Jul; 1(3):pgac128. PMID: 36741442.
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    38. Yonemitsu K, Pan C, Fujiwara Y, Miyasato Y, Shiota T, Yano H, Hosaka S, Tamada K, Yamamoto Y, Komohara Y. GM-CSF derived from the inflammatory microenvironment potentially enhanced PD-L1 expression on tumor-associated macrophages in human breast cancer. Sci Rep. 2022 07 14; 12(1):12007. PMID: 35835809.
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    39. Tsukamoto H, Komohara Y, Tomita Y, Miura Y, Motoshima T, Imamura K, Kimura T, Ikeda T, Fujiwara Y, Yano H, Kamba T, Sakagami T, Oshiumi H. Aging-associated and CD4 T-cell-dependent ectopic CXCL13 activation predisposes to anti-PD-1 therapy-induced adverse events. Proc Natl Acad Sci U S A. 2022 07 19; 119(29):e2205378119. PMID: 35858347.
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    40. Saito Y, Fujiwara Y, Shinchi Y, Mito R, Miura Y, Yamaguchi T, Ikeda K, Urakami S, Nakashima Y, Sakagami T, Suzuki M, Tabata Y, Komohara Y. Classification of PD-L1 expression in various cancers and macrophages based on immunohistocytological analysis. Cancer Sci. 2022 Sep; 113(9):3255-3266. PMID: 35633190.
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    41. Li L, Irie T, Yoshii D, Komohara Y, Fujiwara Y, Esumi S, Kadohisa M, Honda M, Suzu S, Matsuura T, Kohashi K, Oda Y, Hibi T. M-CSFR expression in the embryonal component of hepatoblastoma and cell-to-cell interaction between macrophages and hepatoblastoma. Med Mol Morphol. 2022 Sep; 55(3):236-247. PMID: 35597882.
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    42. Yano H, Fujiwara Y, Horlad H, Pan C, Kai K, Niino D, Ohsawa K, Higashi M, Nosaka K, Okuno Y, Tamaru JI, Mukasa A, Matsuoka M, Komohara Y. Blocking cholesterol efflux mechanism is a potential target for antilymphoma therapy. Cancer Sci. 2022 Jun; 113(6):2129-2143. PMID: 35343027.
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    43. Shinchi Y, Ishizuka S, Komohara Y, Matsubara E, Mito R, Pan C, Yoshii D, Yonemitsu K, Fujiwara Y, Ikeda K, Tamada K, Sakagami T, Suzuki M. The expression of PD-1 ligand 1 on macrophages and its clinical impacts and mechanisms in lung adenocarcinoma. Cancer Immunol Immunother. 2022 Nov; 71(11):2645-2661. PMID: 35352168.
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    44. Tsutsuki H, Zhang T, Yahiro K, Ono K, Fujiwara Y, Iyoda S, Wei FY, Monde K, Seto K, Ohnishi M, Oshiumi H, Akaike T, Sawa T. Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection. iScience. 2022 Apr 15; 25(4):104050. PMID: 35345462.
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    45. Kawaguchi S, Kawahara K, Fujiwara Y, Ohnishi K, Pan C, Yano H, Hirosue A, Nagata M, Hirayama M, Sakata J, Nakashima H, Arita H, Yamana K, Gohara S, Nagao Y, Maeshiro M, Iwamoto A, Hirayama M, Yoshida R, Komohara Y, Nakayama H. Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration. Cancer Immunol Immunother. 2022 Sep; 71(9):2127-2139. PMID: 35044489.
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    46. Torphy RJ, Sun Y, Lin R, Caffrey-Carr A, Fujiwara Y, Ho F, Miller EN, McCarter MD, Lyons TR, Schulick RD, Kedl RM, Zhu Y. GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models. Nat Commun. 2022 01 10; 13(1):97. PMID: 35013216.
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    47. Pan C, Fujiwara Y, Horlad H, Iriki T, Shiraishi D, Komohara Y. Cyclic sulfur compounds targeting macrophage polarization into M2/protumor phenotype and their anti-tumor effects. Cancer Immunol Immunother. 2022 Jun; 71(6):1331-1343. PMID: 34655303.
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    48. Fujiwara Y, Torphy RJ, Sun Y, Miller EN, Ho F, Borcherding N, Wu T, Torres RM, Zhang W, Schulick RD, Zhu Y. The GPR171 pathway suppresses T cell activation and limits antitumor immunity. Nat Commun. 2021 10 06; 12(1):5857. PMID: 34615877.
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    49. Kosaka A, Ishibashi K, Nagato T, Kitamura H, Fujiwara Y, Yasuda S, Nagata M, Harabuchi S, Hayashi R, Yajima Y, Ohara K, Kumai T, Aoki N, Komohara Y, Oikawa K, Harabuchi Y, Kitada M, Kobayashi H, Ohkuri T. CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes. J Exp Med. 2021 11 01; 218(11). PMID: 34559187.
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    50. Yonemitsu K, Miyasato Y, Shiota T, Shinchi Y, Fujiwara Y, Hosaka S, Yamamoto Y, Komohara Y. Soluble Factors Involved in Cancer Cell-Macrophage Interaction Promote Breast Cancer Growth. Anticancer Res. 2021 Sep; 41(9):4249-4258. PMID: 34475044.
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    51. Sun Y, Chen W, Torphy RJ, Yao S, Zhu G, Lin R, Lugano R, Miller EN, Fujiwara Y, Bian L, Zheng L, Anand S, Gao F, Zhang W, Ferrara SE, Goodspeed AE, Dimberg A, Wang XJ, Edil BH, Barnett CC, Schulick RD, Chen L, Zhu Y. Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Sci Transl Med. 2021 07 28; 13(604). PMID: 34321321.
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    52. Matsusaka K, Fujiwara Y, Pan C, Esumi S, Saito Y, Bi J, Nakamura Y, Mukunoki A, Takeo T, Nakagata N, Yoshii D, Fukuda R, Nagasaki T, Tanaka R, Komori H, Maeda H, Watanabe H, Tamada K, Komohara Y, Maruyama T. a1-Acid Glycoprotein Enhances the Immunosuppressive and Protumor Functions of Tumor-Associated Macrophages. Cancer Res. 2021 09 01; 81(17):4545-4559. PMID: 34210751.
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    53. Maeshiro M, Shinriki S, Liu R, Nakachi Y, Komohara Y, Fujiwara Y, Ohtsubo K, Yoshida R, Iwamoto K, Nakayama H, Matsui H. Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress. Sci Rep. 2021 03 17; 11(1):6150. PMID: 33731803.
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    54. Aoyagi S, Fujiwara Y, Takano A, Vorng JL, Gilmore IS, Wang YC, Tallarek E, Hagenhoff B, Iida SI, Luch A, Jungnickel H, Lang Y, Shon HK, Lee TG, Li Z, Matsuda K, Mihara I, Miisho A, Murayama Y, Nagatomi T, Ikeda R, Okamoto M, Saiga K, Tsuchiya T, Uemura S. Evaluation of Time-of-Flight Secondary Ion Mass Spectrometry Spectra of Peptides by Random Forest with Amino Acid Labels: Results from a Versailles Project on Advanced Materials and Standards Interlaboratory Study. Anal Chem. 2021 03 09; 93(9):4191-4197. PMID: 33635050.
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    55. Xiao Y, Xu W, Komohara Y, Fujiwara Y, Hirose H, Futaki S, Niidome T. Effect of Surface Modifications on Cellular Uptake of Gold Nanorods in Human Primary Cells and Established Cell Lines. ACS Omega. 2020 Dec 22; 5(50):32744-32752. PMID: 33376912.
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    56. Halpern AL, Fitz JG, Fujiwara Y, Yi J, Anderson AL, Zhu Y, Schulick RD, El Kasmi KC, Barnett CC. Hepatic thermal injury promotes colorectal cancer engraftment in C57/black 6 mice. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C142-C151. PMID: 33175574.
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    57. Fujiwara Y, Ohnishi K, Horlad H, Saito Y, Shiraishi D, Takeya H, Yoshii D, Kaieda S, Hoshino T, Komohara Y. CD163 deficiency facilitates lipopolysaccharide-induced inflammatory responses and endotoxin shock in mice. Clin Transl Immunology. 2020; 9(9):e1162. PMID: 33005412.
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    58. Ishiuchi K, Amber Syed A, Kosuge Y, Fujiwara Y, Makino T, Hirose D. Decaturenol A and known oxalicine related meroterpenoids isolated from Penicillium decaturense RO050, and their new biological activities. Bioorg Med Chem Lett. 2020 08 15; 30(16):127307. PMID: 32631527.
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    59. Suzuki R, Fujiwara Y, Saito M, Arakawa S, Shirakawa JI, Yamanaka M, Komohara Y, Marumo K, Nagai R. Intracellular Accumulation of Advanced Glycation End Products Induces Osteoblast Apoptosis Via Endoplasmic Reticulum Stress. J Bone Miner Res. 2020 10; 35(10):1992-2003. PMID: 32427355.
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    60. Torphy RJ, Fujiwara Y, Schulick RD. Pancreatic cancer treatment: better, but a long way to go. Surg Today. 2020 Oct; 50(10):1117-1125. PMID: 32474642.
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    61. Fujimura R, Watanabe H, Nishida K, Fujiwara Y, Koga T, Bi J, Imafuku T, Kobayashi K, Komori H, Miyahisa M, Maeda H, Tanaka M, Matsushita K, Wada T, Fukagawa M, Maruyama T. a1-Acid Glycoprotein Attenuates Adriamycin-Induced Nephropathy via CD163 Expressing Macrophage Induction. Kidney360. 2020 05 28; 1(5):343-353. PMID: 35369369.
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    62. Pan C, Fujiwara Y, Horlad H, Shiraishi D, Iriki T, Tsuboki J, Ikeda T, Komohara Y. Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment. Front Pharmacol. 2020; 11:262. PMID: 32256354.
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    63. Kinoshita S, Mera K, Ichikawa H, Shimasaki S, Nagai M, Taga Y, Iijima K, Hattori S, Fujiwara Y, Shirakawa JI, Nagai R. N? -(Carboxymethyl)arginine Is One of the Dominant Advanced Glycation End Products in Glycated Collagens and Mouse Tissues. Oxid Med Cell Longev. 2019; 2019:9073451. PMID: 31583049.
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    64. Tanaka R, Saito Y, Fujiwara Y, Jo JI, Tabata Y. Preparation of fibrin hydrogels to promote the recruitment of anti-inflammatory macrophages. Acta Biomater. 2019 04 15; 89:152-165. PMID: 30862554.
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    65. Tian Y, Sun Y, Gao F, Koenig MR, Sunderland A, Fujiwara Y, Torphy RJ, Chen L, Edil BH, Schulick RD, Zhu Y. CD28H expression identifies resident memory CD8?+?T cells with less cytotoxicity in human peripheral tissues and cancers. Oncoimmunology. 2019; 8(2):e1538440. PMID: 30713797.
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    66. Minayoshi Y, Maeda H, Yanagisawa H, Hamasaki K, Mizuta Y, Nishida K, Kinoshita R, Enoki Y, Imafuku T, Chuang VTG, Koga T, Fujiwara Y, Takeya M, Sonoda K, Wakayama T, Taguchi K, Ishima Y, Ishida T, Iwakiri Y, Tanaka M, Sasaki Y, Watanabe H, Otagiri M, Maruyama T. Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions. Drug Deliv. 2018 Nov; 25(1):1067-1077. PMID: 29688069.
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    67. Fujiwara Y, Sun Y, Torphy RJ, He J, Yanaga K, Edil BH, Schulick RD, Zhu Y. Pomalidomide Inhibits PD-L1 Induction to Promote Antitumor Immunity. Cancer Res. 2018 12 01; 78(23):6655-6665. PMID: 30315115.
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    68. Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y. CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma. Cancer Res. 2018 06 15; 78(12):3255-3266. PMID: 29610117.
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    69. Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami-Nishida S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E. Inhibition of Local Macrophage Growth Ameliorates Focal Inflammation and Suppresses Atherosclerosis. Arterioscler Thromb Vasc Biol. 2018 05; 38(5):994-1006. PMID: 29496659.
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    70. Fujiwara Y, Saito Y, Shiota T, Cheng P, Ikeda T, Ohnishi K, Takeya M, Komohara Y. Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation. J Clin Exp Hematop. 2018; 58(1):17-23. PMID: 29553092.
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    71. Fukuda N, Noi K, Weng L, Kobashigawa Y, Miyazaki H, Wakeyama Y, Takaki M, Nakahara Y, Tatsuno Y, Uchida-Kamekura M, Suwa Y, Sato T, Ichikawa-Tomikawa N, Nomizu M, Fujiwara Y, Ohsaka F, Saitoh T, Maenaka K, Kumeta H, Shinya S, Kojima C, Ogura T, Morioka H. Production of Single-Chain Fv Antibodies Specific for GA-Pyridine, an Advanced Glycation End-Product (AGE), with Reduced Inter-Domain Motion. Molecules. 2017 Oct 10; 22(10). PMID: 28994732.
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    72. Ma C, Horlad H, Pan C, Yano H, Ohnishi K, Fujiwara Y, Matsuoka M, Lee A, Niidome T, Yamanaka R, Takeya M, Komohara Y. Stat3 inhibitor abrogates the expression of PD-1 ligands on lymphoma cell lines. J Clin Exp Hematop. 2017 Jul 05; 57(1):21-25. PMID: 28496056.
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    73. Iriki T, Ohnishi K, Fujiwara Y, Horlad H, Saito Y, Pan C, Ikeda K, Mori T, Suzuki M, Ichiyasu H, Kohrogi H, Takeya M, Komohara Y. The cell-cell interaction between tumor-associated macrophages and small cell lung cancer cells is involved in tumor progression via STAT3 activation. Lung Cancer. 2017 04; 106:22-32. PMID: 28285690.
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    74. Fujiwara Y, Hizukuri Y, Yamashiro K, Makita N, Ohnishi K, Takeya M, Komohara Y, Hayashi Y. Guanylate-binding protein 5 is a marker of interferon-?-induced classically activated macrophages. Clin Transl Immunology. 2016 Nov; 5(11):e111. PMID: 27990286.
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    75. Tsuboki J, Fujiwara Y, Horlad H, Shiraishi D, Nohara T, Tayama S, Motohara T, Saito Y, Ikeda T, Takaishi K, Tashiro H, Yonemoto Y, Katabuchi H, Takeya M, Komohara Y. Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages. Sci Rep. 2016 07 12; 6:29588. PMID: 27404320.
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    76. Ishiuchi K, Jiang WP, Fujiwara Y, Wu JB, Kitanaka S. Serralongamines B-D, three new Lycopodium alkaloids from Lycopodium serratum var. longipetiolatum, and their inhibitory effects on foam cell formation in macrophages. Bioorg Med Chem Lett. 2016 06 01; 26(11):2636-40. PMID: 27086123.
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    77. Yamanaka M, Matsumura T, Ohno R, Fujiwara Y, Shinagawa M, Sugawa H, Hatano K, Shirakawa J, Kinoshita H, Ito K, Sakata N, Araki E, Nagai R. Non-invasive measurement of skin autofluorescence to evaluate diabetic complications. J Clin Biochem Nutr. 2016 Mar; 58(2):135-40. PMID: 27013780.
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    78. Enoki Y, Ishima Y, Tanaka R, Sato K, Kimachi K, Shirai T, Watanabe H, Chuang VT, Fujiwara Y, Takeya M, Otagiri M, Maruyama T. Pleiotropic Effects of Levofloxacin, Fluoroquinolone Antibiotics, against Influenza Virus-Induced Lung Injury. PLoS One. 2015; 10(6):e0130248. PMID: 26086073.
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    79. Nagai R, Shirakawa J, Fujiwara Y, Ohno R, Moroishi N, Sakata N, Nagai M. Detection of AGEs as markers for carbohydrate metabolism and protein denaturation. J Clin Biochem Nutr. 2014 Jul; 55(1):1-6. PMID: 25120273.
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    80. Khan S, Rahman HN, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed KA, Rahaman MM, Oyama K, Takeya M, Ida T, Kawamura Y, Fujii S, Akaike T. Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses. Sci Rep. 2014 Apr 15; 4:4680. PMID: 24732347.
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    81. Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Horlad H, Ikeda T, Nohara T, Takeya M, Nagai R. Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase (ACAT). J Agric Food Chem. 2012 Mar 14; 60(10):2472-9. PMID: 22224814.
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    82. Ohnishi K, Komohara Y, Fujiwara Y, Takemura K, Lei X, Nakagawa T, Sakashita N, Takeya M. Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204). Biochem Biophys Res Commun. 2011 Aug 05; 411(3):516-22. PMID: 21756882.
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