Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Sarah G Faubel

TitleProfessor-Clinical
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-4813

    Collapse Research 
    Collapse research activities and funding
    R01HL157973     (FAUBEL, SARAH G)May 10, 2021 - Apr 30, 2025
    NIH
    Cardiac dysfunction after ischemic AKI in mice
    Role: Principal Investigator
    R21DK114444     (FAUBEL, SARAH G)Aug 1, 2018 - Jul 31, 2021
    NIH
    Immunoparalysis in AKI after cardiac surgery
    Role: Principal Investigator
    R01HL130084     (FAUBEL, SARAH G)Jul 15, 2016 - Apr 30, 2021
    NIH
    The role of acute kidney in the pathogenesis of sepsis from pneumonia
    Role: Principal Investigator
    R56HL095363     (FAUBEL, SARAH G)Sep 1, 2015 - Jul 14, 2016
    NIH
    Mechanisms of susceptibility to sepsis after acute kidney injury
    Role: Principal Investigator
    I01BX001498     (FAUBEL, SARAH G)Jan 1, 2013 - Dec 31, 2016
    NIH
    The anti-inflammatory response after acute kidney injury
    Role: Principal Investigator
    R01HL095363     (FAUBEL, SARAH G)Aug 1, 2009 - May 31, 2015
    NIH
    Acute Renal Failure Mediated Lung Injury
    Role: Principal Investigator
    K08DK065022     (FAUBEL, SARAH)Aug 1, 2003 - Aug 31, 2009
    NIH
    The Role of IL-18 in Ischemic Acute Renal Failure
    Role: Principal Investigator
    F32DK062676     (FAUBEL, SARAH)Apr 30, 2003
    NIH
    Caspase-1 and IL-18 in Ischemic Acute Renal Failure
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Colbert JF, Griffin BR, Rolloff K, Erzen CL, Haeger SM, Altmann C, Okamura K, Campbell R, Teitelbaum I, Faubel S. Hepcidin Removal during Continuous Renal Replacement Therapy. Blood Purif. 2024; 53(1):23-29. PMID: 37926081.
      View in: PubMed
    2. Okamura K, Lu S, He Z, Altmann C, Montford JR, Li AS, Lucia MS, Orlicky DJ, Weiser-Evans M, Faubel S. IL-6 mediates the hepatic acute phase response after prerenal azotemia in a clinically defined murine model. Am J Physiol Renal Physiol. 2023 09 01; 325(3):F328-F344. PMID: 37471421.
      View in: PubMed
    3. Faubel S. Acute kidney injury causes and exacerbates cardiac dysfunction. Am J Physiol Renal Physiol. 2023 06 01; 324(6):F568-F570. PMID: 37167275.
      View in: PubMed
    4. Liberio BM, Seedorf G, Soranno DE, Montford JR, Faubel SG, Hernandez A, Abman SH, Gien J. Acute kidney injury decreases pulmonary vascular growth and alveolarization in neonatal rat pups. Pediatr Res. 2023 Oct; 94(4):1308-1316. PMID: 37138027.
      View in: PubMed
    5. Hukriede NA, Soranno DE, Sander V, Perreau T, Starr MC, Yuen PST, Siskind LJ, Hutchens MP, Davidson AJ, Burmeister DM, Faubel S, de Caestecker MP. Experimental models of acute kidney injury for translational research. Nat Rev Nephrol. 2022 05; 18(5):277-293. PMID: 35173348.
      View in: PubMed
    6. Soranno DE, Baker P, Kirkbride-Romeo L, Wennersten SA, Ding K, Keith B, Cavasin MA, Altmann C, Bagchi RA, Haefner KR, Montford J, Gist KM, Vergnes L, Reue K, He Z, Elajaili H, Okamura K, Nozik E, McKinsey TA, Faubel S. Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia-reperfusion acute kidney injury. Sci Rep. 2022 Jan 12; 12(1):643. PMID: 35022484.
      View in: PubMed
    7. Montford JR, Bauer C, Rahkola J, Reisz JA, Floyd D, Hopp K, Soranno DE, Klawitter J, Weiser-Evans MCM, Nemenoff R, Faubel S, Furgeson SB. 15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction. Am J Physiol Renal Physiol. 2022 01 01; 322(1):F105-F119. PMID: 34866403.
      View in: PubMed
    8. Griffin BR, Ten Eyck P, Faubel S, Jalal D, Gallagher M, Bellomo R. Platelet Decreases following Continuous Renal Replacement Therapy Initiation as a Novel Risk Factor for Renal Nonrecovery. Blood Purif. 2022; 51(7):559-566. PMID: 34521084.
      View in: PubMed
    9. Park BD, Faubel S. Acute Kidney Injury and Acute Respiratory Distress Syndrome. Crit Care Clin. 2021 Oct; 37(4):835-849. PMID: 34548136.
      View in: PubMed
    10. Ambruso SL, Gil HW, Fox B, Park B, Altmann C, Bagchi RA, Baker PR, Reisz JA, Faubel S. Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion. Am J Physiol Lung Cell Mol Physiol. 2021 07 01; 321(1):L50-L64. PMID: 33949208.
      View in: PubMed
    11. Brown CN, Atwood D, Pokhrel D, Holditch SJ, Altmann C, Skrypnyk NI, Bourne J, Klawitter J, Blaine J, Faubel S, Thorburn A, Edelstein CL. Surgical procedures suppress autophagic flux in the kidney. Cell Death Dis. 2021 03 05; 12(3):248. PMID: 33674554.
      View in: PubMed
    12. Soranno DE, Kirkbride-Romeo L, Wennersten SA, Ding K, Cavasin MA, Baker P, Altmann C, Bagchi RA, Haefner KR, Steink?hler C, Montford JR, Keith B, Gist KM, McKinsey TA, Faubel S. Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition. JACC Basic Transl Sci. 2021 Feb; 6(2):119-133. PMID: 33665513.
      View in: PubMed
    13. Griffin BR, Wu C, O'Horo JC, Faubel S, Jalal D, Kashani K. The Association of Platelet Decrease Following Continuous Renal Replacement Therapy Initiation and Increased Rates of Secondary Infections. Crit Care Med. 2021 02 01; 49(2):e130-e139. PMID: 33372743.
      View in: PubMed
    14. Faubel S. SuPAR: a potential predictive biomarker for acute kidney?injury. Nat Rev Nephrol. 2020 07; 16(7):375-376. PMID: 32269303.
      View in: PubMed
    15. Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Faubel S, Aftab M. Creatinine elevations from baseline at the time of cardiac surgery are associated with postoperative complications. J Thorac Cardiovasc Surg. 2022 04; 163(4):1378-1387. PMID: 32739165.
      View in: PubMed
    16. Gist KM, Faubel S. Infection Post-AKI: Should We Worry? Nephron. 2020; 144(12):673-676. PMID: 32564024.
      View in: PubMed
    17. Faubel S. The author replies. Kidney Int. 2020 06; 97(6):1301-1302. PMID: 32444098.
      View in: PubMed
    18. Barhight MF, Brinton JT, Soranno DE, Faubel S, Mourani PM, Gist KM. Effects of hyperchloremia on renal recovery in critically ill children with acute kidney injury. Pediatr Nephrol. 2020 07; 35(7):1331-1339. PMID: 32152726.
      View in: PubMed
    19. Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Gist KM, Jovanovich A, Jalal D, Faubel S, Aftab M. Thrombocytopenia After Cardiopulmonary Bypass Is Associated With Increased Morbidity and Mortality. Ann Thorac Surg. 2020 07; 110(1):50-57. PMID: 31816284.
      View in: PubMed
    20. Skrypnyk NI, Gist KM, Okamura K, Montford JR, You Z, Yang H, Moldovan R, Bodoni E, Blaine JT, Edelstein CL, Soranno DE, Kirkbride-Romeo LA, Griffin BR, Altmann C, Faubel S. IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury. Kidney Int. 2020 05; 97(5):966-979. PMID: 32081304.
      View in: PubMed
    21. Griffin BR, Kohtz PD, Bronsert M, Reece TB, Cleveland JC, Fullerton DA, Faubel S, Aftab M. Postoperative Complications Are Not Elevated in Well-Compensated ESRD Patients Undergoing Cardiac Surgery: End-Stage Renal Disease Cardiac Surgery Outcomes. J Surg Res. 2020 03; 247:136-143. PMID: 31785887.
      View in: PubMed
    22. Griffin BR, Teixeira JP, Ambruso S, Bronsert M, Pal JD, Cleveland JC, Reece TB, Fullerton DA, Faubel S, Aftab M. Stage 1 acute kidney injury is independently associated with infection following cardiac surgery. J Thorac Cardiovasc Surg. 2021 04; 161(4):1346-1355.e3. PMID: 32007252.
      View in: PubMed
    23. Griffin BR, Thomson A, Yoder M, Francis I, Ambruso S, Bregman A, Feller M, Johnson-Bortolotto S, King C, Bonnes D, Dufficy L, Wu C, Bansal A, Tad-Y D, Faubel S, Jalal D. Continuous Renal Replacement Therapy Dosing in Critically Ill Patients: A Quality Improvement Initiative. Am J Kidney Dis. 2019 12; 74(6):727-735. PMID: 31540789.
      View in: PubMed
    24. Griffin BR, You Z, Holmen J, SooHoo M, Gist KM, Colbert JF, Chonchol M, Faubel S, Jovanovich A. Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis. PLoS One. 2019; 14(6):e0217935. PMID: 31233518.
      View in: PubMed
    25. Soranno DE, Gil HW, Kirkbride-Romeo L, Altmann C, Montford JR, Yang H, Levine A, Buchanan J, Faubel S. Matching Human Unilateral AKI, a Reverse Translational Approach to Investigate Kidney Recovery after Ischemia. J Am Soc Nephrol. 2019 06; 30(6):990-1005. PMID: 31072827.
      View in: PubMed
    26. Griffin BR, Faubel S, Edelstein CL. Biomarkers of Drug-Induced Kidney Toxicity. Ther Drug Monit. 2019 04; 41(2):213-226. PMID: 30883514.
      View in: PubMed
    27. Griffin BR, Jovanovich A, You Z, Palevsky P, Faubel S, Jalal D. Effects of Baseline Thrombocytopenia and Platelet Decrease Following Renal Replacement Therapy Initiation in Patients With Severe Acute Kidney Injury. Crit Care Med. 2019 04; 47(4):e325-e331. PMID: 30585829.
      View in: PubMed
    28. Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney Int. 2019 03; 95(3):590-610. PMID: 30709662.
      View in: PubMed
    29. Griffin BR, Gist KM, Faubel S. Current Status of Novel Biomarkers for the Diagnosis of Acute Kidney Injury: A Historical Perspective. J Intensive Care Med. 2020 May; 35(5):415-424. PMID: 30654681.
      View in: PubMed
    30. Teixeira JP, Ambruso S, Griffin BR, Faubel S. Pulmonary Consequences of Acute Kidney Injury. Semin Nephrol. 2019 01; 39(1):3-16. PMID: 30606405.
      View in: PubMed
    31. Barhight MF, Soranno D, Faubel S, Gist KM. Fluid Management With Peritoneal Dialysis After Pediatric Cardiac Surgery. World J Pediatr Congenit Heart Surg. 2018 11; 9(6):696-704. PMID: 30322362.
      View in: PubMed
    32. Barhight MF, Brinton J, Stidham T, Soranno DE, Faubel S, Griffin BR, Goebel J, Mourani PM, Gist KM. Increase in chloride from baseline is independently associated with mortality in critically ill children. Intensive Care Med. 2018 Dec; 44(12):2183-2191. PMID: 30382307.
      View in: PubMed
    33. SooHoo MM, Patel SS, Jaggers J, Faubel S, Gist KM. Acute Kidney Injury Defined by Fluid Corrected Creatinine in Neonates After the Norwood Procedure. World J Pediatr Congenit Heart Surg. 2018 09; 9(5):513-521. PMID: 30157730.
      View in: PubMed
    34. Gist KM, Cooper DS, Wrona J, Faubel S, Altmann C, Gao Z, Marino BS, Alten J, Hock KM, Mizuno T, Vinks AA, Joy MS, Wempe MF, Bennett MR, Goldstein SL. Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. Ther Drug Monit. 2018 04; 40(2):186-194. PMID: 29529007.
      View in: PubMed
    35. SooHoo M, Griffin B, Jovanovich A, Soranno DE, Mack E, Patel SS, Faubel S, Gist KM. Acute kidney injury is associated with subsequent?infection in neonates after the Norwood procedure: a retrospective chart review. Pediatr Nephrol. 2018 07; 33(7):1235-1242. PMID: 29508077.
      View in: PubMed
    36. Barhight MF, Lusk J, Brinton J, Stidham T, Soranno DE, Faubel S, Goebel J, Mourani PM, Gist KM. Hyperchloremia is independently associated with mortality in critically ill children who ultimately require continuous renal replacement therapy. Pediatr Nephrol. 2018 06; 33(6):1079-1085. PMID: 29404689.
      View in: PubMed
    37. Askenazi DJ, Faubel S. The Nephrologist Has Great Potential to Have an Important Role in the Intensive Care Unit: Reply to the Letter to the Editor of David J.R. Morgan. Blood Purif. 2017; 44(4):269-270. PMID: 29020677.
      View in: PubMed
    38. Colbert JF, Ford JA, Haeger SM, Yang Y, Dailey KL, Allison KC, Neudecker V, Evans CM, Richardson VL, Brodsky KS, Faubel S, Eltzschig HK, Schmidt EP, Ginde AA. A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F553-F559. PMID: 28515178.
      View in: PubMed
    39. Gist KM, Goldstein SL, Wrona J, Alten JA, Basu RK, Cooper DS, Soranno DE, Duplantis J, Altmann C, Gao Z, Faubel S. Kinetics of the cell cycle arrest biomarkers (TIMP-2*IGFBP-7) for prediction of acute kidney injury in infants after cardiac surgery. Pediatr Nephrol. 2017 09; 32(9):1611-1619. PMID: 28382566.
      View in: PubMed
    40. Altmann C, Ahuja N, Kiekhaefer CM, Andres Hernando A, Okamura K, Bhargava R, Duplantis J, Kirkbride-Romeo LA, Huckles J, Fox BM, Kahn K, Soranno D, Gil HW, Teitelbaum I, Faubel S. Early peritoneal dialysis reduces lung inflammation in mice with ischemic acute kidney injury. Kidney Int. 2017 08; 92(2):365-376. PMID: 28318621.
      View in: PubMed
    41. Andres-Hernando A, Okamura K, Bhargava R, Kiekhaefer CM, Soranno D, Kirkbride-Romeo LA, Gil HW, Altmann C, Faubel S. Circulating IL-6 upregulates IL-10 production in splenic CD4+ T cells and limits acute kidney injury-induced lung inflammation. Kidney Int. 2017 05; 91(5):1057-1069. PMID: 28214022.
      View in: PubMed
    42. Colbert JF, Schmidt EP, Faubel S, Ginde AA. Severe Sepsis Outcomes Among Hospitalizations With Inflammatory Bowel Disease. Shock. 2017 02; 47(2):128-131. PMID: 27617672.
      View in: PubMed
    43. Askenazi DJ, Heung M, Connor MJ, Basu RK, Cerd? J, Doi K, Koyner JL, Bihorac A, Golestaneh L, Vijayan A, Okusa MD, Faubel S. Optimal Role of the Nephrologist in the Intensive Care Unit. Blood Purif. 2017; 43(1-3):68-77. PMID: 27923227.
      View in: PubMed
    44. Faubel S, Shah PB. Immediate Consequences of Acute Kidney Injury: The Impact of Traditional and Nontraditional Complications on Mortality in Acute Kidney Injury. Adv Chronic Kidney Dis. 2016 05; 23(3):179-85. PMID: 27113694.
      View in: PubMed
    45. Gist KM, Kaufman J, da Cruz EM, Friesen RH, Crumback SL, Linders M, Edelstein C, Altmann C, Palmer C, Jalal D, Faubel S. A Decline in Intraoperative Renal Near-Infrared Spectroscopy Is Associated With Adverse Outcomes in Children Following Cardiac Surgery. Pediatr Crit Care Med. 2016 Apr; 17(4):342-9. PMID: 26914625.
      View in: PubMed
    46. Skrypnyk NI, Siskind LJ, Faubel S, de Caestecker MP. Bridging translation for acute kidney injury with better preclinical modeling of human disease. Am J Physiol Renal Physiol. 2016 05 15; 310(10):F972-84. PMID: 26962107.
      View in: PubMed
    47. Soranno DE, Rodell CB, Altmann C, Duplantis J, Andres-Hernando A, Burdick JA, Faubel S. Delivery of interleukin-10 via injectable hydrogels improves renal outcomes and reduces systemic inflammation following ischemic acute kidney injury in mice. Am J Physiol Renal Physiol. 2016 08 01; 311(2):F362-72. PMID: 26962109.
      View in: PubMed
    48. Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, Nolin TD, Bihorac A. Clinical Use of the Urine Biomarker [TIMP-2]?? [IGFBP7] for?Acute Kidney Injury Risk Assessment. Am J Kidney Dis. 2016 07; 68(1):19-28. PMID: 26948834.
      View in: PubMed
    49. de Caestecker M, Humphreys BD, Liu KD, Fissell WH, Cerda J, Nolin TD, Askenazi D, Mour G, Harrell FE, Pullen N, Okusa MD, Faubel S. Bridging Translation by Improving Preclinical Study Design in AKI. J Am Soc Nephrol. 2015 Dec; 26(12):2905-16. PMID: 26538634.
      View in: PubMed
    50. Faubel S, Edelstein CL. Mechanisms and mediators of lung injury after acute kidney injury. Nat Rev Nephrol. 2016 Jan; 12(1):48-60. PMID: 26434402.
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    51. Dobrinskikh E, Lewis L, Brian Doctor R, Okamura K, Lee MG, Altmann C, Faubel S, Kopp JB, Blaine J. Shank2 Regulates Renal Albumin Endocytosis. Physiol Rep. 2015 Sep; 3(9). PMID: 26333830.
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    52. Heung M, Faubel S, Watnick S, Cruz DN, Koyner JL, Mour G, Liu KD, Cerda J, Okusa MD, Lukaszewski M, Vijayan A. Outpatient Dialysis for Patients with AKI: A Policy Approach to Improving Care. Clin J Am Soc Nephrol. 2015 Oct 07; 10(10):1868-74. PMID: 26220818.
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    53. Cerd? J, Liu KD, Cruz DN, Jaber BL, Koyner JL, Heung M, Okusa MD, Faubel S. Promoting Kidney Function Recovery in Patients with AKI Requiring RRT. Clin J Am Soc Nephrol. 2015 Oct 07; 10(10):1859-67. PMID: 26138260.
      View in: PubMed
    54. Rodell CB, Rai R, Faubel S, Burdick JA, Soranno DE. Local immunotherapy via delivery of interleukin-10 and transforming growth factor ? antagonist for treatment of chronic kidney disease. J Control Release. 2015 May 28; 206:131-9. PMID: 25804871.
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    55. Faubel S, Franch H, Vijayan A, Barron MA, Heung M, Liu KD, Koyner JL, Conner MJ. Preparing for renal replacement therapy in patients with the Ebola virus disease. Blood Purif. 2014; 38(3-4):276-85. PMID: 25675963.
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    56. Lee DW, Faubel S, Edelstein CL. A pan caspase inhibitor decreases caspase-1, IL-1a and IL-1?, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules. Ren Fail. 2015 Feb; 37(1):144-50. PMID: 25310769.
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    57. Hung KW, Blaine J, Faubel S. Dual therapy difficulties in angiotensin blockade for proteinuria: a teachable moment. JAMA Intern Med. 2014 Sep; 174(9):1429-30. PMID: 25089763.
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    58. Andres-Hernando A, Altmann C, Bhargava R, Okamura K, Bacalja J, Hunter B, Ahuja N, Soranno D, Faubel S. Prolonged acute kidney injury exacerbates lung inflammation at 7 days post-acute kidney injury. Physiol Rep. 2014 Jul 01; 2(7). PMID: 25052489.
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    59. Koyner JL, Cerd? J, Goldstein SL, Jaber BL, Liu KD, Shea JA, Faubel S. The daily burden of acute kidney injury: a survey of U.S. nephrologists on World Kidney Day. Am J Kidney Dis. 2014 Sep; 64(3):394-401. PMID: 24815216.
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    60. Faubel S. Renal relevant radiology: introduction. Clin J Am Soc Nephrol. 2014 Feb; 9(2):371-2. PMID: 24510108.
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    61. Faubel S. Have we reached the limit of mortality benefit with our approach to renal replacement therapy in acute kidney injury? Am J Kidney Dis. 2013 Dec; 62(6):1030-3. PMID: 24267387.
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    62. Faubel S, Patel NU, Lockhart ME, Cadnapaphornchai MA. Renal relevant radiology: use of ultrasonography in patients with AKI. Clin J Am Soc Nephrol. 2014 Feb; 9(2):382-94. PMID: 24235286.
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    63. Bhargava R, Altmann CJ, Andres-Hernando A, Webb RG, Okamura K, Yang Y, Falk S, Schmidt EP, Faubel S. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-a antibodies. PLoS One. 2013; 8(11):e79037. PMID: 24265742.
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    64. Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. Heparanase mediates renal dysfunction during early sepsis in mice. Physiol Rep. 2013 Nov; 1(6):e00153. PMID: 24400155.
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    65. Bhargava R, Janssen W, Altmann C, Andr?s-Hernando A, Okamura K, Vandivier RW, Ahuja N, Faubel S. Intratracheal IL-6 protects against lung inflammation in direct, but not indirect, causes of acute lung injury in mice. PLoS One. 2013; 8(5):e61405. PMID: 23667439.
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    66. Wang H, Capell W, Yoon JH, Faubel S, Eckel RH. Obesity development in caspase-1-deficient mice. Int J Obes (Lond). 2014 Jan; 38(1):152-5. PMID: 23689355.
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    67. Goldstein SL, Jaber BL, Faubel S, Chawla LS. AKI transition of care: a potential opportunity to detect and prevent CKD. Clin J Am Soc Nephrol. 2013 Mar; 8(3):476-83. PMID: 23471414.
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    68. Okamura K, Dummer P, Kopp J, Qiu L, Levi M, Faubel S, Blaine J. Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death. PLoS One. 2013; 8(1):e54817. PMID: 23382978.
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    69. Sirota JC, Walcher A, Faubel S, Jani A, McFann K, Devarajan P, Davis CL, Edelstein CL. Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation. BMC Nephrol. 2013 Jan 17; 14:17. PMID: 23327592.
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    70. Ahuja N, Andres-Hernando A, Altmann C, Bhargava R, Bacalja J, Webb RG, He Z, Edelstein CL, Faubel S. Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice. Am J Physiol Renal Physiol. 2012 Sep 15; 303(6):F864-72. PMID: 22791336.
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    71. Andres-Hernando A, Dursun B, Altmann C, Ahuja N, He Z, Bhargava R, Edelstein CE, Jani A, Hoke TS, Klein C, Faubel S. Cytokine production increases and cytokine clearance decreases in mice with bilateral nephrectomy. Nephrol Dial Transplant. 2012 Dec; 27(12):4339-47. PMID: 22778179.
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    72. Amura CR, Renner B, Lyubchenko T, Faubel S, Simonian PL, Thurman JM. Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion. Mol Immunol. 2012 Oct; 52(3-4):249-57. PMID: 22750071.
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    73. Molitoris BA, Okusa MD, Palevsky PM, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene TH, Faubel SG, Kellum JA, Wald R, Chertow GM, Levin A, Waikar SS, Murray PT, Parikh CR, Shaw AD, Go AS, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Mehta RL, Stokes JB, Thompson AM, Thompson BT, Westenfelder CS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA. Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings. Clin J Am Soc Nephrol. 2012 May; 7(5):856-60. PMID: 22442184.
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    74. Palevsky PM, Molitoris BA, Okusa MD, Levin A, Waikar SS, Wald R, Chertow GM, Murray PT, Parikh CR, Shaw AD, Go AS, Faubel SG, Kellum JA, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene T, Mehta RL, Stokes JB, Thompson AM, Thompson BT, Westenfelder CS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA. Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology. Clin J Am Soc Nephrol. 2012 May; 7(5):844-50. PMID: 22442182.
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    75. Okusa MD, Molitoris BA, Palevsky PM, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Faubel S, Kellum JA, Wald R, Chertow GM, Levin A, Waikar SS, Murray PT, Parikh CR, Shaw AD, Go AS, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene TH, Mehta RL, Stokes JB, Thompson AM, Thompson BT, Westenfelder CS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA. Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials. Clin J Am Soc Nephrol. 2012 May; 7(5):851-5. PMID: 22442188.
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    76. Faubel S, Chawla LS, Chertow GM, Goldstein SL, Jaber BL, Liu KD. Ongoing clinical trials in AKI. Clin J Am Soc Nephrol. 2012 May; 7(5):861-73. PMID: 22442183.
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    77. Lu L, Faubel S, He Z, Andres Hernando A, Jani A, Kedl R, Edelstein CL. Depletion of macrophages and dendritic cells in ischemic acute kidney injury. Am J Nephrol. 2012; 35(2):181-90. PMID: 22286667.
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    78. Altmann C, Andres-Hernando A, McMahan RH, Ahuja N, He Z, Rivard CJ, Edelstein CL, Barthel L, Janssen WJ, Faubel S. Macrophages mediate lung inflammation in a mouse model of ischemic acute kidney injury. Am J Physiol Renal Physiol. 2012 Feb 15; 302(4):F421-32. PMID: 22114207.
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    79. Faubel S, Edelstein CL. Acute kidney injury: Severity of illness scoring systems in acute kidney injury. Nat Rev Nephrol. 2011 Nov 01; 8(1):8-10. PMID: 22045237.
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    80. Akcay A, Nguyen Q, He Z, Turkmen K, Won Lee D, Hernando AA, Altmann C, Toker A, Pacic A, Ljubanovic DG, Jani A, Faubel S, Edelstein CL. IL-33 exacerbates acute kidney injury. J Am Soc Nephrol. 2011 Nov; 22(11):2057-67. PMID: 21949094.
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    81. Walcher A, Faubel S, Keniston A, Dennen P. In critically ill patients requiring CRRT, AKI is associated with increased respiratory failure and death versus ESRD. Ren Fail. 2011; 33(10):935-42. PMID: 21910664.
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    82. Lee DW, Faubel S, Edelstein CL. Cytokines in acute kidney injury (AKI). Clin Nephrol. 2011 Sep; 76(3):165-73. PMID: 21888852.
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    83. Redente EF, Jacobsen KM, Solomon JJ, Lara AR, Faubel S, Keith RC, Henson PM, Downey GP, Riches DW. Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L510-8. PMID: 21743030.
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    84. Andr?s-Hernando A, Altmann C, Ahuja N, Lanaspa MA, Nemenoff R, He Z, Ishimoto T, Simpson PA, Weiser-Evans MC, Bacalja J, Faubel S. Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice. Am J Physiol Renal Physiol. 2011 Oct; 301(4):F907-16. PMID: 21677145.
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    85. Turkmen K, Martin J, Akcay A, Nguyen Q, Ravichandran K, Faubel S, Pacic A, Ljubanovic D, Edelstein CL, Jani A. Apoptosis and autophagy in cold preservation ischemia. Transplantation. 2011 Jun 15; 91(11):1192-7. PMID: 21577181.
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    86. Dennen P, Altmann C, Kaufman J, Klein CL, Andres-Hernando A, Ahuja NH, Edelstein CL, Cadnapaphornchai MA, Keniston A, Faubel S. Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery. Crit Care. 2010; 14(5):R181. PMID: 20942931.
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    87. Faubel S. Acute kidney injury and multiple organ dysfunction syndrome. Minerva Urol Nefrol. 2009 Sep; 61(3):171-88. PMID: 19773721.
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    88. Liu KD, Altmann C, Smits G, Krawczeski CD, Edelstein CL, Devarajan P, Faubel S. Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Crit Care. 2009; 13(4):R104. PMID: 19570208.
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    89. He Z, Dursun B, Oh DJ, Lu L, Faubel S, Edelstein CL. Macrophages are not the source of injurious interleukin-18 in ischemic acute kidney injury in mice. Am J Physiol Renal Physiol. 2009 Mar; 296(3):F535-42. PMID: 19129255.
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    90. He Z, Lu L, Altmann C, Hoke TS, Ljubanovic D, Jani A, Dinarello CA, Faubel S, Edelstein CL. Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury. Am J Physiol Renal Physiol. 2008 Nov; 295(5):F1414-21. PMID: 18753296.
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    91. Zhou Z, Gengaro P, Wang W, Wang XQ, Li C, Faubel S, Rivard C, Schrier RW. Role of NF-kappaB and PI 3-kinase/Akt in TNF-alpha-induced cytotoxicity in microvascular endothelial cells. Am J Physiol Renal Physiol. 2008 Oct; 295(4):F932-41. PMID: 18632801.
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    92. Klein CL, Hoke TS, Fang WF, Altmann CJ, Douglas IS, Faubel S. Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy. Kidney Int. 2008 Oct; 74(7):901-9. PMID: 18596724.
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    93. Faubel S, Edelstein CL. Exciting times in research regarding the definition, diagnosis, complications, and outcomes of acute kidney injury. Adv Chronic Kidney Dis. 2008 Jul; 15(3):211-2. PMID: 18565472.
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    94. Faubel S. Pulmonary complications after acute kidney injury. Adv Chronic Kidney Dis. 2008 Jul; 15(3):284-96. PMID: 18565479.
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    95. Wang W, Zolty E, Falk S, Summer S, Zhou Z, Gengaro P, Faubel S, Alp N, Channon K, Schrier R. Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1. Am J Physiol Renal Physiol. 2008 Mar; 294(3):F571-6. PMID: 18171994.
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    96. Oh DJ, Dursun B, He Z, Lu L, Hoke TS, Ljubanovic D, Faubel S, Edelstein CL. Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Am J Physiol Renal Physiol. 2008 Jan; 294(1):F264-71. PMID: 18003857.
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    97. Lu LH, Oh DJ, Dursun B, He Z, Hoke TS, Faubel S, Edelstein CL. Increased macrophage infiltration and fractalkine expression in cisplatin-induced acute renal failure in mice. J Pharmacol Exp Ther. 2008 Jan; 324(1):111-7. PMID: 17932247.
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    98. Tao Y, Kim J, Yin Y, Zafar I, Falk S, He Z, Faubel S, Schrier RW, Edelstein CL. VEGF receptor inhibition slows the progression of polycystic kidney disease. Kidney Int. 2007 Dec; 72(11):1358-66. PMID: 17882148.
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    99. Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, Oh DJ, Lu L, Klein CL, Dinarello CA, Edelstein CL. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther. 2007 Jul; 322(1):8-15. PMID: 17400889.
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    100. Edelstein CL, Hoke TS, Somerset H, Fang W, Klein CL, Dinarello CA, Faubel S. Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury. Nephrol Dial Transplant. 2007 Apr; 22(4):1052-61. PMID: 17255124.
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    101. Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S. Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007 Jan; 18(1):155-64. PMID: 17167117.
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    102. Dursun B, He Z, Somerset H, Oh DJ, Faubel S, Edelstein CL. Caspases and calpain are independent mediators of cisplatin-induced endothelial cell necrosis. Am J Physiol Renal Physiol. 2006 Sep; 291(3):F578-87. PMID: 16622172.
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    103. Jani A, Wang W, Faubel S, Falk S, Ljubanovic D, Dursun B, Edelstein CL. Ischemic acute renal failure following nephrectomy impairs long-term renal function. Transplantation. 2006 Mar 15; 81(5):800-3. PMID: 16534486.
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    104. Faubel S, Ljubanovic D, Poole B, Dursun B, He Z, Cushing S, Somerset H, Gill RG, Edelstein CL. Peripheral CD4 T-cell depletion is not sufficient to prevent ischemic acute renal failure. Transplantation. 2005 Sep 15; 80(5):643-9. PMID: 16177639.
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    105. Faubel S, Edelstein CL. Caspases as drug targets in ischemic organ injury. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Sep; 5(3):269-87. PMID: 16178788.
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    106. Tao Y, Kim J, Faubel S, Wu JC, Falk SA, Schrier RW, Edelstein CL. Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6954-9. PMID: 15863619.
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    107. Tao Y, Kim J, Stanley M, He Z, Faubel S, Schrier RW, Edelstein CL. Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD). Kidney Int. 2005 Mar; 67(3):909-19. PMID: 15698430.
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    108. Wang W, Faubel S, Ljubanovic D, Mitra A, Falk SA, Kim J, Tao Y, Soloviev A, Reznikov LL, Dinarello CA, Schrier RW, Edelstein CL. Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice. Am J Physiol Renal Physiol. 2005 May; 288(5):F997-1004. PMID: 15644489.
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    109. Faubel S, Ljubanovic D, Reznikov L, Somerset H, Dinarello CA, Edelstein CL. Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis. Kidney Int. 2004 Dec; 66(6):2202-13. PMID: 15569309.
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    110. Jani A, Ljubanovic D, Faubel S, Kim J, Mischak R, Edelstein CL. Caspase inhibition prevents the increase in caspase-3, -2, -8 and -9 activity and apoptosis in the cold ischemic mouse kidney. Am J Transplant. 2004 Aug; 4(8):1246-54. PMID: 15268725.
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    111. Parikh CR, Jani A, Melnikov VY, Faubel S, Edelstein CL. Urinary interleukin-18 is a marker of human acute tubular necrosis. Am J Kidney Dis. 2004 Mar; 43(3):405-14. PMID: 14981598.
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