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Andrew Pratt Goodwin

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentChemical & Biological Engin
Phone303/492-3573

    Collapse Research 
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    R21CA267608     (GOODWIN, ANDREW P)Jun 15, 2022 - May 31, 2025
    NIH
    Macrophage-Mediated Delivery of Acoustically Propelled Nanoparticles for Sensitizing Immunologically Cold Tumors
    Role: Principal Investigator
    R21AR078506     (CHA, JENNIFER N ;GOODWIN, ANDREW P)Jan 13, 2021 - Dec 31, 2022
    NIH
    Controllable 2- and 3D Assembly of Mechanically Robust Skin Tissue Via Long Term Expression of DNA on Cell Membranes
    Role: Co-Principal Investigator
    R21GM135668     (GOODWIN, ANDREW P)Jan 1, 2020 - Dec 31, 2021
    NIH
    Affinity-Mediated Covalent Conjugation: A Method for Direct Modification of Specific Receptors on Cell Membranes
    Role: Principal Investigator
    R21EB027319     (GOODWIN, ANDREW P)Jan 1, 2019 - May 31, 2021
    NIH
    Nonlinear Photoacoustic Response from Functionalized Gold and Metal Oxide Nanostructures
    Role: Principal Investigator
    R21EB026006     (GOODWIN, ANDREW P)Apr 1, 2018 - Oct 31, 2020
    NIH
    Effect of Container Surface Structure on Cavitation-Induced Protein Particulate Formation
    Role: Principal Investigator
    R03EB021432     (GOODWIN, ANDREW P)May 7, 2016 - Feb 28, 2018
    NIH
    Hollow Silica-Polymer Nanocomposites for Stimulus-Responsive Ultrasound Contrast
    Role: Principal Investigator
    R21EB020911     (CHA, JENNIFER N)Jul 1, 2015 - Apr 30, 2018
    NIH
    Biomolecule-Directed Assembly for Enhancing Near IR Energy Transfer Processes in Theranostics
    Role: Co-Principal Investigator
    DP2EB020401     (GOODWIN, ANDREW P)Sep 30, 2014 - Jun 30, 2019
    NIH
    Rapid, Multiscale Sensing Using Acoustic Detection Mechanisms
    Role: Principal Investigator
    R21EB018034     (GOODWIN, ANDREW P)Sep 19, 2014 - Jun 30, 2016
    NIH
    Targeted Microbubbles for Noninvasive Measurement of Tumor VEGF Levels
    Role: Principal Investigator
    R00CA153935     (GOODWIN, ANDREW P)Sep 7, 2010 - Jul 31, 2016
    NIH
    Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents
    Role: Principal Investigator
    K99CA153935     (GOODWIN, ANDREW P.)Sep 7, 2010 - Jul 31, 2012
    NIH
    Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents for
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Saemundsson SA, Ganguly S, Curry SD, Goodwin AP, Cha JN. Controlling Cell Organization in 3D Coculture Spheroids Using DNA Interactions. ACS Biomater Sci Eng. 2023 06 12; 9(6):3185-3192. PMID: 37155244.
      View in: PubMed
    2. Mueller EN, Alina TB, Curry SD, Ganguly S, Cha JN, Goodwin AP. Silica-coated gold nanorods with hydrophobic modification show both enhanced two-photon fluorescence and ultrasound drug release. J Mater Chem B. 2022 12 07; 10(47):9789-9793. PMID: 36420680.
      View in: PubMed
    3. Roy S, Curry SD, Corbella Bagot C, Mueller EN, Mansouri AM, Park W, Cha JN, Goodwin AP. Enzyme Prodrug Therapy with Photo-Cross-Linkable Anti-EGFR Affibodies Conjugated to Upconverting Nanoparticles. ACS Nano. 2022 10 25; 16(10):15873-15883. PMID: 36129781.
      View in: PubMed
    4. Ganguly S, Roy S, Goodwin AP, Cha JN. Generation of 3D cellular spheroids using DNA modified cell receptors and programmable DNA interactions. Biomater Sci. 2021 Nov 23; 9(23):7911-7920. PMID: 34694305.
      View in: PubMed
    5. Mueller EN, Kuriakose M, Ganguly S, Ma K, Inzunza-Ibarra MA, Murray TW, Cha JN, Goodwin AP. Hydrophobically Modified Silica-Coated Gold Nanorods for Generating Nonlinear Photoacoustic Signals. ACS Appl Nano Mater. 2021 Nov 26; 4(11):12073-12082. PMID: 38031593.
      View in: PubMed
    6. Roy S, Curry SD, Bibbey MG, Chapnick DA, Liu X, Goodwin AP, Cha JN. Effect of covalent photoconjugation of affibodies to epidermal growth factor receptor (EGFR) on cellular quiescence. Biotechnol Bioeng. 2022 01; 119(1):187-198. PMID: 34676884.
      View in: PubMed
    7. Movafaghi S, Daniels AL, Kelly MD, Witeof AE, Calderon CP, Randolph TW, Goodwin AP. Hydrogel Coatings on Container Surfaces Reduce Protein Aggregation Caused by Mechanical Stress and Cavitation. ACS Appl Bio Mater. 2021 09 20; 4(9):6946-6953. PMID: 35006994.
      View in: PubMed
    8. Wu H, Movafaghi S, Francino Urd?niz IM, Rowe TM, Goodwin A, Randolph TW. Insulin Fibril Formation Caused by Mechanical Shock and Cavitation. J Phys Chem B. 2021 07 29; 125(29):8021-8027. PMID: 34260251.
      View in: PubMed
    9. Parameswar AV, Dikshit KV, Movafaghi S, Bruns CJ, Goodwin AP. Mechanochemistry Activated Covalent Conjugation Reactions in Soft Hydrogels Induced by Interfacial Failure. ACS Appl Mater Interfaces. 2021 Jan 13; 13(1):1486-1492. PMID: 33370089.
      View in: PubMed
    10. Harris AW, Roy S, Ganguly S, Parameswar AV, Lucas FWS, Holewinski A, Goodwin AP, Cha JN. Investigating the use of conducting oligomers and redox molecules in CdS-MoFeP biohybrids. Nanoscale Adv. 2021 Mar 09; 3(5):1392-1396. PMID: 36132854.
      View in: PubMed
    11. Roy S, Cha JN, Goodwin AP. Nongenetic Bioconjugation Strategies for Modifying Cell Membranes and Membrane Proteins: A Review. Bioconjug Chem. 2020 11 18; 31(11):2465-2475. PMID: 33146010.
      View in: PubMed
    12. Movafaghi S, Wu H, Francino Urd?niz IM, Bull DS, Kelly MD, Randolph TW, Goodwin AP. The Effect of Container Surface Passivation on Aggregation of Intravenous Immunoglobulin Induced by Mechanical Shock. Biotechnol J. 2020 Sep; 15(9):e2000096. PMID: 32437086.
      View in: PubMed
    13. Harris AW, Harguindey A, Patalano RE, Roy S, Yehezkeli O, Goodwin AP, Cha JN. Investigating Protein-Nanocrystal Interactions for Photodriven Activity. ACS Appl Bio Mater. 2020 Feb 17; 3(2):1026-1035. PMID: 35019304.
      View in: PubMed
    14. Roy S, Brasino M, Beirne JM, Harguindey A, Chapnick DA, Liu X, Cha JN, Goodwin AP. Enzymes Photo-Cross-Linked to Live Cell Receptors Retain Activity and EGFR Inhibition after Both Internalization and Recycling. Bioconjug Chem. 2020 01 15; 31(1):104-112. PMID: 31840981.
      View in: PubMed
    15. Blum NT, Gyorkos CM, Narowetz SJ, Mueller EN, Goodwin AP. Phospholipid-Coated Hydrophobic Mesoporous Silica Nanoparticles Enhance Thrombectomy by High-Intensity Focused Ultrasound with Low Production of Embolism-Inducing Clot Debris. ACS Appl Mater Interfaces. 2019 Oct 09; 11(40):36324-36332. PMID: 31556582.
      View in: PubMed
    16. Hafenstine GR, Patalano RE, Harris AW, Jiang G, Ma K, Goodwin AP, Cha JN. Solar Photocatalytic Phenol Polymerization and Hydrogen Generation for Flocculation of Wastewater Impurities. ACS Appl Polym Mater. 2019 Jun 14; 1(6):1451-1457. PMID: 37206614.
      View in: PubMed
    17. Bull DS, Kienle DF, Chaparro Sosa AF, Nelson N, Roy S, Cha JN, Schwartz DK, Kaar JL, Goodwin AP. Surface-Templated Nanobubbles Protect Proteins from Surface-Mediated Denaturation. J Phys Chem Lett. 2019 Jun 06; 10(11):2641-2647. PMID: 31067058.
      View in: PubMed
    18. Blum NT, Yildirim A, Gyorkos C, Shi D, Cai A, Chattaraj R, Goodwin AP. Temperature-Responsive Hydrophobic Silica Nanoparticle Ultrasound Contrast Agents Directed by Phospholipid Phase Behavior. ACS Appl Mater Interfaces. 2019 May 01; 11(17):15233-15240. PMID: 31012297.
      View in: PubMed
    19. Yildirim A, Blum NT, Goodwin AP. Colloids, nanoparticles, and materials for imaging, delivery, ablation, and theranostics by focused ultrasound (FUS). Theranostics. 2019; 9(9):2572-2594. PMID: 31131054.
      View in: PubMed
    20. Harguindey A, Roy S, Harris AW, Fairbanks BD, Goodwin AP, Bowman CN, Cha JN. Click Nucleic Acid Mediated Loading of Prodrug Activating Enzymes in PEG-PLGA Nanoparticles for Combination Chemotherapy. Biomacromolecules. 2019 04 08; 20(4):1683-1690. PMID: 30884222.
      View in: PubMed
    21. Chattaraj R, Blum NT, Goodwin AP. Design and Application of Stimulus-Responsive Droplets and Bubbles Stabilized by Phospholipid Monolayers. Curr Opin Colloid Interface Sci. 2019 Apr; 40:14-24. PMID: 31086500.
      View in: PubMed
    22. Yildirim A, Shi D, Roy S, Blum NT, Chattaraj R, Cha JN, Goodwin AP. Nanoparticle-Mediated Acoustic Cavitation Enables High Intensity Focused Ultrasound Ablation Without Tissue Heating. ACS Appl Mater Interfaces. 2018 Oct 31; 10(43):36786-36795. PMID: 30339360.
      View in: PubMed
    23. Brasino M, Roy S, Erbse AH, He L, Mao C, Park W, Cha JN, Goodwin AP. Anti-EGFR Affibodies with Site-Specific Photo-Cross-Linker Incorporation Show Both Directed Target-Specific Photoconjugation and Increased Retention in Tumors. J Am Chem Soc. 2018 09 19; 140(37):11820-11828. PMID: 30203972.
      View in: PubMed
    24. He L, Mao C, Brasino M, Harguindey A, Park W, Goodwin AP, Cha JN. TiO2-Capped Gold Nanorods for Plasmon-Enhanced Production of Reactive Oxygen Species and Photothermal Delivery of Chemotherapeutic Agents. ACS Appl Mater Interfaces. 2018 Aug 22; 10(33):27965-27971. PMID: 30044085.
      View in: PubMed
    25. Parameswar AV, Fitch KR, Bull DS, Duke VR, Goodwin AP. Polyacrylamide Hydrogels Produce Hydrogen Peroxide from Osmotic Swelling in Aqueous Media. Biomacromolecules. 2018 08 13; 19(8):3421-3426. PMID: 30052430.
      View in: PubMed
    26. Bull DS, Nelson N, Konetski D, Bowman CN, Schwartz DK, Goodwin AP. Contact Line Pinning Is Not Required for Nanobubble Stability on Copolymer Brushes. J Phys Chem Lett. 2018 Aug 02; 9(15):4239-4244. PMID: 30010342.
      View in: PubMed
    27. Hafenstine GR, Harris AW, Ma K, Cha JN, Goodwin AP. Conversion of Ethanol to 2-Ethylhexenal at Ambient Conditions Using Tandem, Biphasic Catalysis. ACS Sustain Chem Eng. 2017; 5(11):10483-10489. PMID: 33224638.
      View in: PubMed
    28. Harris AW, Yehezkeli O, Hafenstine GR, Goodwin AP, Cha JN. Light-Driven Catalytic Upgrading of Butanol in a Biohybrid Photoelectrochemical System. ACS Sustain Chem Eng. 2017; 5(9):8199-8204. PMID: 33133786.
      View in: PubMed
    29. Yildirim A, Chattaraj R, Blum NT, Shi D, Kumar K, Goodwin AP. Phospholipid Capped Mesoporous Nanoparticles for Targeted High Intensity Focused Ultrasound Ablation. Adv Healthc Mater. 2017 Sep; 6(18). PMID: 28699308.
      View in: PubMed
    30. He L, Brasino M, Mao C, Cho S, Park W, Goodwin AP, Cha JN. DNA-Assembled Core-Satellite Upconverting-Metal-Organic Framework Nanoparticle Superstructures for Efficient Photodynamic Therapy. Small. 2017 06; 13(24). PMID: 28481463.
      View in: PubMed
    31. Blum NT, Yildirim A, Chattaraj R, Goodwin AP. Nanoparticles Formed by Acoustic Destruction of Microbubbles and Their Utilization for Imaging and Effects on Therapy by High Intensity Focused Ultrasound. Theranostics. 2017; 7(3):694-702. PMID: 28255360.
      View in: PubMed
    32. Hafenstine GR, Ma K, Harris AW, Yehezkeli O, Park E, Domaille DW, Cha JN, Goodwin AP. Multicatalytic, Light-Driven Upgrading of Butanol to 2-Ethylhexenal and Hydrogen under Mild Aqueous Conditions. ACS Catal. 2017; 7(1):568-572. PMID: 33133753.
      View in: PubMed
    33. Chattaraj R, Goldscheitter GM, Yildirim A, Goodwin AP. Phase Behavior of Mixed Lipid Monolayers on Perfluorocarbon Nanoemulsions and its Effect on Acoustic Contrast. RSC Adv. 2016 Dec 04; 6(112):111318-111325. PMID: 28603605.
      View in: PubMed
    34. Yildirim A, Chattaraj R, Blum NT, Goodwin AP. Understanding Acoustic Cavitation Initiation by Porous Nanoparticles: Toward Nanoscale Agents for Ultrasound Imaging and Therapy. Chem Mater. 2016 08 23; 28(16):5962-5972. PMID: 28484307.
      View in: PubMed
    35. He L, Dragavon J, Cho S, Mao C, Yildirim A, Ma K, Chattaraj R, Goodwin AP, Park W, Cha JN. Self-assembled gold nanostar-NaYF4:Yb/Er clusters for multimodal imaging, photothermal and photodynamic therapy. J Mater Chem B. 2016 Jul 07; 4(25):4455-4461. PMID: 32263428.
      View in: PubMed
    36. Kumar K, Casta?o EJ, Weidner AR, Yildirim A, Goodwin AP. Depolymerizable Poly(O-vinyl carbamate-alt-sulfones) as Customizable Macromolecular Scaffolds for Mucosal Drug Delivery. ACS Macro Lett. 2016 May 17; 5(5):636-640. PMID: 28480130.
      View in: PubMed
    37. Yildirim A, Chattaraj R, Blum NT, Goldscheitter GM, Goodwin AP. Stable Encapsulation of Air in Mesoporous Silica Nanoparticles: Fluorocarbon-Free Nanoscale Ultrasound Contrast Agents. Adv Healthc Mater. 2016 06; 5(11):1290-8. PMID: 26990167.
      View in: PubMed
    38. Domaille DW, Hafenstine GR, Greer MA, Goodwin AP, Cha JN. Catalytic Upgrading in Bacteria-Compatible Conditions via a Biocompatible Aldol Condensation. ACS Sustain Chem Eng. 2016 Mar 07; 4(3):671-675. PMID: 28480149.
      View in: PubMed
    39. Chattaraj R, Mohan P, Livingston CM, Besmer JD, Kumar K, Goodwin AP. Mutually-Reactive, Fluorogenic Hydrocyanine/Quinone Reporter Pairs for In-Solution Biosensing via Nanodroplet Association. ACS Appl Mater Interfaces. 2016 Jan 13; 8(1):802-8. PMID: 26710239.
      View in: PubMed
    40. Kumar K, Goodwin AP. Alternating Sulfone Copolymers Depolymerize in Response to Both Chemical and Mechanical Stimuli. ACS Macro Lett. 2015 Sep 15; 4(9):907-911. PMID: 28480129.
      View in: PubMed
    41. Chattaraj R, Mohan P, Besmer JD, Goodwin AP. Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive, Acoustic Biosensing. Adv Healthc Mater. 2015 Aug 26; 4(12):1790-5. PMID: 26084414.
      View in: PubMed
    42. Mohan P, Noonan PS, Nakatsuka MA, Goodwin AP. On-demand droplet fusion: a strategy for stimulus-responsive biosensing in solution. Langmuir. 2014 Oct 21; 30(41):12321-7. PMID: 25263344.
      View in: PubMed
    43. Goodwin AP, Nakatsuka MA, Mattrey RF. Stimulus-responsive ultrasound contrast agents for clinical imaging: motivations, demonstrations, and future directions. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Jan-Feb; 7(1):111-23. PMID: 25195785.
      View in: PubMed
    44. Noonan PS, Mohan P, Goodwin AP, Schwartz DK. DNA Hybridization-Mediated Liposome Fusion at the Aqueous Liquid Crystal Interface. Adv Funct Mater. 2014 Jun 04; 24(21):3206-3212. PMID: 25506314.
      View in: PubMed
    45. Nakatsuka MA, Barback CV, Fitch KR, Farwell AR, Esener SC, Mattrey RF, Cha JN, Goodwin AP. In vivo ultrasound visualization of non-occlusive blood clots with thrombin-sensitive contrast agents. Biomaterials. 2013 Dec; 34(37):9559-65. PMID: 24034499.
      View in: PubMed
    46. Xu PF, Noh H, Lee JH, Domaille DW, Nakatsuka MA, Goodwin AP, Cha JN. Imparting the unique properties of DNA into complex material architectures and functions. Mater Today (Kidlington). 2013 Jul; 16(7-8):290-296. PMID: 25525408.
      View in: PubMed
    47. Nakatsuka MA, Mattrey RF, Esener SC, Cha JN, Goodwin AP. Aptamer-crosslinked microbubbles: smart contrast agents for thrombin-activated ultrasound imaging. Adv Mater. 2012 Nov 27; 24(45):6010-6. PMID: 22941789.
      View in: PubMed
    48. Nakatsuka MA, Hsu MJ, Esener SC, Cha JN, Goodwin AP. DNA-coated microbubbles with biochemically tunable ultrasound contrast activity. Adv Mater. 2011 Nov 09; 23(42):4908-12. PMID: 21956383.
      View in: PubMed
    49. Hsu MJ, Eghtedari M, Goodwin AP, Hall DJ, Mattrey RF, Esener SC. Characterization of individual ultrasound microbubble dynamics with a light-scattering system. J Biomed Opt. 2011 Jun; 16(6):067002. PMID: 21721823.
      View in: PubMed
    50. Nakatsuka MA, Lee JH, Nakayama E, Hung AM, Hsu MJ, Mattrey RF, Esener SC, Cha JN, Goodwin AP. Facile One-Pot Synthesis of Polymer-Phospholipid Composite Microbubbles with Enhanced Drug Loading Capacity for Ultrasound-Triggered Therapy. Soft Matter. 2011; 2011(7):1656-1659. PMID: 21799701.
      View in: PubMed
    51. Lee JH, Sherlock SP, Terashima M, Kosuge H, Suzuki Y, Goodwin A, Robinson J, Seo WS, Liu Z, Luong R, McConnell MV, Nishimura DG, Dai H. High-contrast in vivo visualization of microvessels using novel FeCo/GC magnetic nanocrystals. Magn Reson Med. 2009 Dec; 62(6):1497-509. PMID: 19859938.
      View in: PubMed
    52. Prencipe G, Tabakman SM, Welsher K, Liu Z, Goodwin AP, Zhang L, Henry J, Dai H. PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation. J Am Chem Soc. 2009 Apr 08; 131(13):4783-7. PMID: 19173646.
      View in: PubMed
    53. Goodwin AP, Tabakman SM, Welsher K, Sherlock SP, Prencipe G, Dai H. Phospholipid-dextran with a single coupling point: a useful amphiphile for functionalization of nanomaterials. J Am Chem Soc. 2009 Jan 14; 131(1):289-96. PMID: 19061329.
      View in: PubMed
    54. Liu Z, Fan AC, Rakhra K, Sherlock S, Goodwin A, Chen X, Yang Q, Felsher DW, Dai H. Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy. Angew Chem Int Ed Engl. 2009; 48(41):7668-72. PMID: 19760685.
      View in: PubMed
    55. Chen Z, Tabakman SM, Goodwin AP, Kattah MG, Daranciang D, Wang X, Zhang G, Li X, Liu Z, Utz PJ, Jiang K, Fan S, Dai H. Protein microarrays with carbon nanotubes as multicolor Raman labels. Nat Biotechnol. 2008 Nov; 26(11):1285-92. PMID: 18953353.
      View in: PubMed
    56. Sun X, Liu Z, Welsher K, Robinson JT, Goodwin A, Zaric S, Dai H. Nano-Graphene Oxide for Cellular Imaging and Drug Delivery. Nano Res. 2008; 1(3):203-212. PMID: 20216934.
      View in: PubMed
    57. Mynar JL, Goodwin AP, Cohen JA, Ma Y, Fleming GR, Fr?chet JM. Two-photon degradable supramolecular assemblies of linear-dendritic copolymers. Chem Commun (Camb). 2007 May 28; (20):2081-2. PMID: 17713085.
      View in: PubMed
    58. Goodwin AP, Lam SS, Fr?chet JM. Rapid, efficient synthesis of heterobifunctional biodegradable dendrimers. J Am Chem Soc. 2007 Jun 06; 129(22):6994-5. PMID: 17489595.
      View in: PubMed
    59. Goodwin AP, Mynar JL, Ma Y, Fleming GR, Fr?chet JM. Synthetic micelle sensitive to IR light via a two-photon process. J Am Chem Soc. 2005 Jul 20; 127(28):9952-3. PMID: 16011330.
      View in: PubMed
    60. Kwon YJ, Standley SM, Goodwin AP, Gillies ER, Fr?chet JM. Directed antigen presentation using polymeric microparticulate carriers degradable at lysosomal pH for controlled immune responses. Mol Pharm. 2005 Jan-Feb; 2(1):83-91. PMID: 15804181.
      View in: PubMed
    61. Gillies ER, Goodwin AP, Fr?chet JM. Acetals as pH-sensitive linkages for drug delivery. Bioconjug Chem. 2004 Nov-Dec; 15(6):1254-63. PMID: 15546191.
      View in: PubMed
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