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Robert Ira Scheinman

TitleAssoc Professor-Clinical
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-3383

    Collapse Research 
    Collapse research activities and funding
    R21DA048350     (MONTE, ANDREW ALBERT)Sep 15, 2020 - Sep 14, 2022
    NIH
    A FUNCTIONAL CELL BASED ASSAY FOR SYNTHETIC CANNABINOIDS
    Role: Co-Principal Investigator

    R21DK062820     (SCHEINMAN, ROBERT IRA)May 1, 2003 - Apr 30, 2006
    NIH
    Molecular Dissection of Immunoregulatory Function
    Role: Principal Investigator

    R21AR048432     (SCHEINMAN, ROBERT IRA)Sep 28, 2001 - Jul 31, 2003
    NIH
    Selective Disruptive of TNFalpha Signaling in Murine CIA
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li Y, Jacques S, Gaikwad H, Wang G, Banda NK, Holers VM, Scheinman RI, Tomlinson S, Moghimi SM, Simberg D. Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins. Nat Nanotechnol. 2023 Oct 05. PMID: 37798566.
      View in: PubMed
    2. Scheinman RI, Banda NK. Does complement play a role in pathogenic ACPA? Arthritis Rheumatol. 2023 11; 75(11):2062-2063. PMID: 37134127.
      View in: PubMed
    3. Gaikwad H, Li Y, Wang G, Li R, Dai S, Rester C, Kedl R, Saba L, Banda NK, Scheinman RI, Patrick C, Mallela KMG, Moghimi SM, Simberg D. Antibody-Dependent Complement Responses toward SARS-CoV-2 Receptor-Binding Domain Immobilized on "Pseudovirus-like" Nanoparticles. ACS Nano. 2022 May 04. PMID: 35507641.
      View in: PubMed
    4. Gaikwad H, Li Y, Gifford G, Groman E, Banda NK, Saba L, Scheinman R, Wang G, Simberg D. Correction to "Complement Inhibitors Block Complement C3 Opsonization and Improve Targeting Selectivity of Nanoparticles in Blood". Bioconjug Chem. 2021 Sep 15; 32(9):2128. PMID: 34478264.
      View in: PubMed
    5. Li Y, Wang G, Griffin L, Banda NK, Saba LM, Groman EV, Scheinman R, Moghimi SM, Simberg D. Complement opsonization of nanoparticles: Differences between humans and preclinical species. J Control Release. 2021 10 10; 338:548-556. PMID: 34481928.
      View in: PubMed
    6. Banda NK, Tomlinson S, Scheinman RI, Ho N, Ramirez JR, Mehta G, Wang G, Vu VP, Simberg D, Kulik L, Holers VM. C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice. Front Immunol. 2020; 11:575154. PMID: 33178202.
      View in: PubMed
    7. Yang C, Chen F, Ren P, Lofchy L, Wan C, Shen J, Wang G, Gaikwad H, Ponder J, Jordan CT, Scheinman R, Simberg D. Delivery of a model lipophilic membrane cargo to bone marrow via cell-derived microparticles. J Control Release. 2020 10 10; 326:324-334. PMID: 32682903.
      View in: PubMed
    8. Gaikwad H, Li Y, Gifford G, Groman E, Banda NK, Saba L, Scheinman R, Wang G, Simberg D. Complement Inhibitors Block Complement C3 Opsonization and Improve Targeting Selectivity of Nanoparticles in Blood. Bioconjug Chem. 2020 07 15; 31(7):1844-1856. PMID: 32598839.
      View in: PubMed
    9. Holers VM, Borodovsky A, Scheinman RI, Ho N, Ramirez JR, Dob? J, G?l P, Lindenberger J, Hansen AG, Desai D, Pihl R, Thiel S, Banda NK. Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D. Front Immunol. 2020; 11:201. PMID: 32153567.
      View in: PubMed
    10. Wang G, Serkova NJ, Groman EV, Scheinman RI, Simberg D. Feraheme (Ferumoxytol) Is Recognized by Proinflammatory and Anti-inflammatory Macrophages via Scavenger Receptor Type AI/II. Mol Pharm. 2019 10 07; 16(10):4274-4281. PMID: 31556296.
      View in: PubMed
    11. Lofchy LA, Vu VP, Banda NK, Ramirez JR, Smith WJ, Gifford G, Gaikwad H, Scheinman RI, Simberg D. Evaluation of Targeting Efficiency of Joints with Anticollagen II Antibodies. Mol Pharm. 2019 06 03; 16(6):2445-2451. PMID: 31091104.
      View in: PubMed
    12. Gifford G, Vu VP, Banda NK, Holers VM, Wang G, Groman EV, Backos D, Scheinman R, Moghimi SM, Simberg D. Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55. J Control Release. 2019 05 28; 302:181-189. PMID: 30974134.
      View in: PubMed
    13. Vu VP, Gifford GB, Chen F, Benasutti H, Wang G, Groman EV, Scheinman R, Saba L, Moghimi SM, Simberg D. Publisher Correction: Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles. Nat Nanotechnol. 2019 Mar; 14(3):298. PMID: 30670872.
      View in: PubMed
    14. Vu VP, Gifford GB, Chen F, Benasutti H, Wang G, Groman EV, Scheinman R, Saba L, Moghimi SM, Simberg D. Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles. Nat Nanotechnol. 2019 03; 14(3):260-268. PMID: 30643271.
      View in: PubMed
    15. Banda NK, Desai D, Scheinman RI, Pihl R, Sekine H, Fujita T, Sharma V, Hansen AG, Garred P, Thiel S, Borodovsky A, Holers VM. Targeting of Liver Mannan-Binding Lectin-Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis. Immunohorizons. 2018 Sep; 2(8):274-295. PMID: 30417171.
      View in: PubMed
    16. Benasutti H, Wang G, Vu VP, Scheinman R, Groman E, Saba L, Simberg D. Variability of Complement Response toward Preclinical and Clinical Nanocarriers in the General Population. Bioconjug Chem. 2017 11 15; 28(11):2747-2755. PMID: 29090582.
      View in: PubMed
    17. Griffin JI, Wang G, Smith WJ, Vu VP, Scheinman R, Stitch D, Moldovan R, Moghimi SM, Simberg D. Revealing Dynamics of Accumulation of Systemically Injected Liposomes in the Skin by Intravital Microscopy. ACS Nano. 2017 11 28; 11(11):11584-11593. PMID: 29045127.
      View in: PubMed
    18. Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Endo Y, Zhou W, Farrar CA, Sacks SH, Fujita T, Sekine H, Holers VM. Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2. J Immunol. 2017 09 01; 199(5):1835-1845. PMID: 28739878.
      View in: PubMed
    19. Banda NK, Acharya S, Scheinman RI, Mehta G, Coulombe M, Takahashi M, Sekine H, Thiel S, Fujita T, Holers VM. Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing. J Immunol. 2016 11 01; 197(9):3680-3694. PMID: 27707997.
      View in: PubMed
    20. Mehta G, Scheinman RI, Holers VM, Banda NK. A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA. J Immunol. 2015 Jun 01; 194(11):5446-54. PMID: 25917104.
      View in: PubMed
    21. Scheinman R. NF-?B and Rheumatoid Arthritis: Will Understanding Genetic Risk Lead to a Therapeutic Reward? For Immunopathol Dis Therap. 2013 Apr 01; 4(2):93-110. PMID: 24678426.
      View in: PubMed
    22. Kadam RS, Scheinman RI, Kompella UB. Pigmented-MDCK (P-MDCK) cell line with tunable melanin expression: an in vitro model for the outer blood-retinal barrier. Mol Pharm. 2012 Nov 05; 9(11):3228-35. PMID: 23003570.
      View in: PubMed
    23. Scheinman RI. Rheumatology mini focus. Future Med Chem. 2012 Apr; 4(6):697-9. PMID: 22530632.
      View in: PubMed
    24. Scheinman RI. Pleiotropic targets: the problem of shared signaling circuitry in rheumatoid arthritis disease progression and protection. Future Med Chem. 2012 Apr; 4(6):735-50. PMID: 22530638.
      View in: PubMed
    25. Scheinman RI, Trivedi R, Vermillion S, Kompella UB. Functionalized STAT1 siRNA nanoparticles regress rheumatoid arthritis in a mouse model. Nanomedicine (Lond). 2011 Dec; 6(10):1669-82. PMID: 22087799.
      View in: PubMed
    26. Thakur A, Scheinman RI, Rao VR, Kompella UB. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov; 82(3):346-50. PMID: 21945644.
      View in: PubMed
    27. Baid R, Scheinman RI, Shinohara T, Singh DP, Kompella UB. LEDGF(1-326) decreases P23H and wild type rhodopsin aggregates and P23H rhodopsin mediated cell damage in human retinal pigment epithelial cells. PLoS One. 2011; 6(9):e24616. PMID: 21915354.
      View in: PubMed
    28. Bai X, Chmura K, Ovrutsky AR, Bowler RP, Scheinman RI, Oberley-Deegan RE, Liu H, Shang S, Ordway D, Chan ED. Mycobacterium tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription. Tuberculosis (Edinb). 2011 Jan; 91(1):26-35. PMID: 21167783.
      View in: PubMed
    29. Weiser-Evans MC, Wang XQ, Amin J, Van Putten V, Choudhary R, Winn RA, Scheinman R, Simpson P, Geraci MW, Nemenoff RA. Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis. Cancer Res. 2009 Mar 01; 69(5):1733-8. PMID: 19208832.
      View in: PubMed
    30. Williams-Skipp C, Raman T, Valuck RJ, Watkins H, Palmer BE, Scheinman RI. Unmasking of a protective tumor necrosis factor receptor I-mediated signal in the collagen-induced arthritis model. Arthritis Rheum. 2009 Feb; 60(2):408-18. PMID: 19180511.
      View in: PubMed
    31. Crowell CK, Qin Q, Grampp GE, Radcliffe RA, Rogers GN, Scheinman RI. Sodium butyrate alters erythropoietin glycosylation via multiple mechanisms. Biotechnol Bioeng. 2008 Jan 01; 99(1):201-13. PMID: 17570711.
      View in: PubMed
    32. Crowell CK, Grampp GE, Rogers GN, Miller J, Scheinman RI. Amino acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system. Biotechnol Bioeng. 2007 Feb 15; 96(3):538-49. PMID: 16937399.
      View in: PubMed
    33. Kupfer R, Lang J, Williams-Skipp C, Nelson M, Bellgrau D, Scheinman RI. Loss of a gimap/ian gene leads to activation of NF-kappaB through a MAPK-dependent pathway. Mol Immunol. 2007 Jan; 44(4):479-87. PMID: 16584774.
      View in: PubMed
    34. Tao Y, Kupfer R, Stewart BJ, Williams-Skipp C, Crowell CK, Patel DD, Sain S, Scheinman RI. AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix. Mol Immunol. 2006 Feb; 43(4):335-45. PMID: 16310047.
      View in: PubMed
    35. Lang JA, Kominski D, Bellgrau D, Scheinman RI. Partial activation precedes apoptotic death in T cells harboring an IAN gene mutation. Eur J Immunol. 2004 Sep; 34(9):2396-406. PMID: 15307172.
      View in: PubMed
    36. Wheat W, Kupfer R, Gutches DG, Rayat GR, Beilke J, Scheinman RI, Wegmann DR. Increased NF-kappa B activity in B cells and bone marrow-derived dendritic cells from NOD mice. Eur J Immunol. 2004 May; 34(5):1395-404. PMID: 15114673.
      View in: PubMed
    37. Kupfer R, Scheinman RI. Measurement of IKK activity in primary rat T cells: rapid activation and inactivation. J Immunol Methods. 2002 Aug 01; 266(1-2):155-64. PMID: 12133632.
      View in: PubMed
    38. Spalding AC, Jotte RM, Scheinman RI, Geraci MW, Clarke P, Tyler KL, Johnson GL. TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene. 2002 Jan 10; 21(2):260-71. PMID: 11803469.
      View in: PubMed
    39. Moore JK, Scheinman RI, Bellgrau D. The identification of a novel T cell activation state controlled by a diabetogenic gene. J Immunol. 2001 Jan 01; 166(1):241-8. PMID: 11123298.
      View in: PubMed
    40. Tao Y, Williams-Skipp C, Scheinman RI. Mapping of glucocorticoid receptor DNA binding domain surfaces contributing to transrepression of NF-kappa B and induction of apoptosis. J Biol Chem. 2001 Jan 26; 276(4):2329-32. PMID: 11106637.
      View in: PubMed
    41. Lin B, Williams-Skipp C, Tao Y, Schleicher MS, Cano LL, Duke RC, Scheinman RI. NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type. Cell Death Differ. 1999 Jun; 6(6):570-82. PMID: 10381655.
      View in: PubMed
    42. McCarthy GM, Augustine JA, Baldwin AS, Christopherson PA, Cheung HS, Westfall PR, Scheinman RI. Molecular mechanism of basic calcium phosphate crystal-induced activation of human fibroblasts. Role of nuclear factor kappab, activator protein 1, and protein kinase c. J Biol Chem. 1998 Dec 25; 273(52):35161-9. PMID: 9857053.
      View in: PubMed
    43. Scheller A, Scheinman RI, Thompson E, Scarlett CO, Robins DM. Contextual dependence of steroid receptor function on an androgen-responsive enhancer. Mol Cell Endocrinol. 1996 Jul 23; 121(1):75-86. PMID: 8865168.
      View in: PubMed
    44. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science. 1995 Oct 13; 270(5234):283-6. PMID: 7569975.
      View in: PubMed
    45. Paine E, Scheinman RI, Baldwin AS, Raab-Traub N. Expression of LMP1 in epithelial cells leads to the activation of a select subset of NF-kappa B/Rel family proteins. J Virol. 1995 Jul; 69(7):4572-6. PMID: 7769726.
      View in: PubMed
    46. Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol Cell Biol. 1995 Feb; 15(2):943-53. PMID: 7823959.
      View in: PubMed
    47. Scheinman RI, Beg AA, Baldwin AS. NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule. Mol Cell Biol. 1993 Oct; 13(10):6089-101. PMID: 8413211.
      View in: PubMed
    48. Cogswell PC, Scheinman RI, Baldwin AS. Promoter of the human NF-kappa B p50/p105 gene. Regulation by NF-kappa B subunits and by c-REL. J Immunol. 1993 Apr 01; 150(7):2794-804. PMID: 8454856.
      View in: PubMed
    49. Beg AA, Ruben SM, Scheinman RI, Haskill S, Rosen CA, Baldwin AS. I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention. Genes Dev. 1992 Oct; 6(10):1899-913. PMID: 1340770.
      View in: PubMed
    50. Scheinman RI, Auld VJ, Goldin AL, Davidson N, Dunn RJ, Catterall WA. Developmental regulation of sodium channel expression in the rat forebrain. J Biol Chem. 1989 Jun 25; 264(18):10660-6. PMID: 2543677.
      View in: PubMed
    51. Wollner DA, Scheinman R, Catterall WA. Sodium channel expression and assembly during development of retinal ganglion cells. Neuron. 1988 Oct; 1(8):727-37. PMID: 2856102.
      View in: PubMed
    52. Olson MV, Dutchik JE, Graham MY, Brodeur GM, Helms C, Frank M, MacCollin M, Scheinman R, Frank T. Random-clone strategy for genomic restriction mapping in yeast. Proc Natl Acad Sci U S A. 1986 Oct; 83(20):7826-30. PMID: 3463999.
      View in: PubMed
    53. Levy RJ, Gundberg C, Scheinman R. The identification of the vitamin K-dependent bone protein osteocalcin as one of the gamma-carboxyglutamic acid containing proteins present in calcified atherosclerotic plaque and mineralized heart valves. Atherosclerosis. 1983 Jan; 46(1):49-56. PMID: 6601488.
      View in: PubMed
    54. Pluznik DH, Rotter V, Scheinman R. Kinetics of proliferation of splenic macrophage precursor cells during the early primary immune response. J Reticuloendothel Soc. 1972 Feb; 11(2):154-66. PMID: 4555127.
      View in: PubMed
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