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Robert Ira Scheinman

TitleAssoc Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-3383

    Collapse Research 
    Collapse research activities and funding
    R21AR048432     (SCHEINMAN, ROBERT IRA)Sep 28, 2001 - Jul 31, 2003
    NIH/NIAMS
    Selective Disruptive of TNFalpha Signaling in Murine CIA
    Role: Principal Investigator

    R21DK062820     (SCHEINMAN, ROBERT IRA)May 1, 2003 - Apr 30, 2006
    NIH/NIDDK
    Molecular Dissection of Immunoregulatory Function
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Banda NK, Acharya S, Scheinman RI, Mehta G, Coulombe M, Takahashi M, Sekine H, Thiel S, Fujita T, Holers VM. Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing. J Immunol. 2016 Nov 01; 197(9):3680-3694. PMID: 27707997.
      View in: PubMed
    2. Mehta G, Scheinman RI, Holers VM, Banda NK. A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA. J Immunol. 2015 Jun 01; 194(11):5446-54. PMID: 25917104.
      View in: PubMed
    3. Scheinman R. NF-?B and Rheumatoid Arthritis: Will Understanding Genetic Risk Lead to a Therapeutic Reward? For Immunopathol Dis Therap. 2013 Apr 01; 4(2):93-110. PMID: 24678426.
      View in: PubMed
    4. Kadam RS, Scheinman RI, Kompella UB. Pigmented-MDCK (P-MDCK) cell line with tunable melanin expression: an in vitro model for the outer blood-retinal barrier. Mol Pharm. 2012 Nov 05; 9(11):3228-35. PMID: 23003570.
      View in: PubMed
    5. Scheinman RI. Rheumatology mini focus. Future Med Chem. 2012 Apr; 4(6):697-9. PMID: 22530632.
      View in: PubMed
    6. Scheinman RI. Pleiotropic targets: the problem of shared signaling circuitry in rheumatoid arthritis disease progression and protection. Future Med Chem. 2012 Apr; 4(6):735-50. PMID: 22530638.
      View in: PubMed
    7. Scheinman RI, Trivedi R, Vermillion S, Kompella UB. Functionalized STAT1 siRNA nanoparticles regress rheumatoid arthritis in a mouse model. Nanomedicine (Lond). 2011 Dec; 6(10):1669-82. PMID: 22087799.
      View in: PubMed
    8. Thakur A, Scheinman RI, Rao VR, Kompella UB. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov; 82(3):346-50. PMID: 21945644.
      View in: PubMed
    9. Baid R, Scheinman RI, Shinohara T, Singh DP, Kompella UB. LEDGF(1-326) decreases P23H and wild type rhodopsin aggregates and P23H rhodopsin mediated cell damage in human retinal pigment epithelial cells. PLoS One. 2011; 6(9):e24616. PMID: 21915354.
      View in: PubMed
    10. Bai X, Chmura K, Ovrutsky AR, Bowler RP, Scheinman RI, Oberley-Deegan RE, Liu H, Shang S, Ordway D, Chan ED. Mycobacterium tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription. Tuberculosis (Edinb). 2011 Jan; 91(1):26-35. PMID: 21167783.
      View in: PubMed
    11. Weiser-Evans MC, Wang XQ, Amin J, Van Putten V, Choudhary R, Winn RA, Scheinman R, Simpson P, Geraci MW, Nemenoff RA. Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis. Cancer Res. 2009 Mar 01; 69(5):1733-8. PMID: 19208832.
      View in: PubMed
    12. Williams-Skipp C, Raman T, Valuck RJ, Watkins H, Palmer BE, Scheinman RI. Unmasking of a protective tumor necrosis factor receptor I-mediated signal in the collagen-induced arthritis model. Arthritis Rheum. 2009 Feb; 60(2):408-18. PMID: 19180511.
      View in: PubMed
    13. Crowell CK, Qin Q, Grampp GE, Radcliffe RA, Rogers GN, Scheinman RI. Sodium butyrate alters erythropoietin glycosylation via multiple mechanisms. Biotechnol Bioeng. 2008 Jan 01; 99(1):201-13. PMID: 17570711.
      View in: PubMed
    14. Crowell CK, Grampp GE, Rogers GN, Miller J, Scheinman RI. Amino acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system. Biotechnol Bioeng. 2007 Feb 15; 96(3):538-49. PMID: 16937399.
      View in: PubMed
    15. Kupfer R, Lang J, Williams-Skipp C, Nelson M, Bellgrau D, Scheinman RI. Loss of a gimap/ian gene leads to activation of NF-kappaB through a MAPK-dependent pathway. Mol Immunol. 2007 Jan; 44(4):479-87. PMID: 16584774.
      View in: PubMed
    16. Tao Y, Kupfer R, Stewart BJ, Williams-Skipp C, Crowell CK, Patel DD, Sain S, Scheinman RI. AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix. Mol Immunol. 2006 Feb; 43(4):335-45. PMID: 16310047.
      View in: PubMed
    17. Lang JA, Kominski D, Bellgrau D, Scheinman RI. Partial activation precedes apoptotic death in T cells harboring an IAN gene mutation. Eur J Immunol. 2004 Sep; 34(9):2396-406. PMID: 15307172.
      View in: PubMed
    18. Wheat W, Kupfer R, Gutches DG, Rayat GR, Beilke J, Scheinman RI, Wegmann DR. Increased NF-kappa B activity in B cells and bone marrow-derived dendritic cells from NOD mice. Eur J Immunol. 2004 May; 34(5):1395-404. PMID: 15114673.
      View in: PubMed
    19. Kupfer R, Scheinman RI. Measurement of IKK activity in primary rat T cells: rapid activation and inactivation. J Immunol Methods. 2002 Aug 01; 266(1-2):155-64. PMID: 12133632.
      View in: PubMed
    20. Luckey SW, Taylor M, Sampey BP, Scheinman RI, Petersen DR. 4-hydroxynonenal decreases interleukin-6 expression and protein production in primary rat Kupffer cells by inhibiting nuclear factor-kappaB activation. J Pharmacol Exp Ther. 2002 Jul; 302(1):296-303. PMID: 12065730.
      View in: PubMed
    21. Cota-Gomez A, Flores NC, Cruz C, Casullo A, Aw TY, Ichikawa H, Schaack J, Scheinman R, Flores SC. The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism. J Biol Chem. 2002 Apr 26; 277(17):14390-9. PMID: 11827962.
      View in: PubMed
    22. Spalding AC, Jotte RM, Scheinman RI, Geraci MW, Clarke P, Tyler KL, Johnson GL. TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene. 2002 Jan 10; 21(2):260-71. PMID: 11803469.
      View in: PubMed
    23. Moore JK, Scheinman RI, Bellgrau D. The identification of a novel T cell activation state controlled by a diabetogenic gene. J Immunol. 2001 Jan 01; 166(1):241-8. PMID: 11123298.
      View in: PubMed
    24. Tao Y, Williams-Skipp C, Scheinman RI. Mapping of glucocorticoid receptor DNA binding domain surfaces contributing to transrepression of NF-kappa B and induction of apoptosis. J Biol Chem. 2001 Jan 26; 276(4):2329-32. PMID: 11106637.
      View in: PubMed
    25. Pawlowski JE, Nesterov A, Scheinman RI, Johnson TR, Kraft AS. NF-kappa B does not modulate sensitivity of renal carcinoma cells to TNF alpha-related apoptosis-inducing ligand (TRAIL). Anticancer Res. 2000 Nov-Dec; 20(6B):4243-55. PMID: 11205254.
      View in: PubMed
    26. Lin B, Williams-Skipp C, Tao Y, Schleicher MS, Cano LL, Duke RC, Scheinman RI. NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type. Cell Death Differ. 1999 Jun; 6(6):570-82. PMID: 10381655.
      View in: PubMed
    27. McCarthy GM, Augustine JA, Baldwin AS, Christopherson PA, Cheung HS, Westfall PR, Scheinman RI. Molecular mechanism of basic calcium phosphate crystal-induced activation of human fibroblasts. Role of nuclear factor kappab, activator protein 1, and protein kinase c. J Biol Chem. 1998 Dec 25; 273(52):35161-9. PMID: 9857053.
      View in: PubMed
    28. Scheller A, Scheinman RI, Thompson E, Scarlett CO, Robins DM. Contextual dependence of steroid receptor function on an androgen-responsive enhancer. Mol Cell Endocrinol. 1996 Jul 23; 121(1):75-86. PMID: 8865168.
      View in: PubMed
    29. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science. 1995 Oct 13; 270(5234):283-6. PMID: 7569975.
      View in: PubMed
    30. Paine E, Scheinman RI, Baldwin AS, Raab-Traub N. Expression of LMP1 in epithelial cells leads to the activation of a select subset of NF-kappa B/Rel family proteins. J Virol. 1995 Jul; 69(7):4572-6. PMID: 7769726.
      View in: PubMed
    31. Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol Cell Biol. 1995 Feb; 15(2):943-53. PMID: 7823959.
      View in: PubMed
    32. Scheinman RI, Beg AA, Baldwin AS. NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule. Mol Cell Biol. 1993 Oct; 13(10):6089-101. PMID: 8413211.
      View in: PubMed
    33. Cogswell PC, Scheinman RI, Baldwin AS. Promoter of the human NF-kappa B p50/p105 gene. Regulation by NF-kappa B subunits and by c-REL. J Immunol. 1993 Apr 01; 150(7):2794-804. PMID: 8454856.
      View in: PubMed
    34. Beg AA, Ruben SM, Scheinman RI, Haskill S, Rosen CA, Baldwin AS. I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention. Genes Dev. 1992 Oct; 6(10):1899-913. PMID: 1340770.
      View in: PubMed
    35. Scheinman RI, Auld VJ, Goldin AL, Davidson N, Dunn RJ, Catterall WA. Developmental regulation of sodium channel expression in the rat forebrain. J Biol Chem. 1989 Jun 25; 264(18):10660-6. PMID: 2543677.
      View in: PubMed
    36. Wollner DA, Scheinman R, Catterall WA. Sodium channel expression and assembly during development of retinal ganglion cells. Neuron. 1988 Oct; 1(8):727-37. PMID: 2856102.
      View in: PubMed
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