Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Douglas R Seals

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentIntegrative Physiology
Phone303/492-5305

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA. Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance. Proc Natl Acad Sci U S A. 2017 Feb 28; 114(9):2313-2318.
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    2. Tanaka H, Dinenno FA, Seals DR. Reductions in central arterial compliance with age are related to sympathetic vasoconstrictor nerve activity in healthy men. Hypertens Res. 2017 Jan 19.
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    3. Santos-Parker JR, Strahler TR, Bassett CJ, Bispham NZ, Chonchol MB, Seals DR. Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress. Aging (Albany NY). 2017 Jan 03; 9(1):187-208.
      View in: PubMed
    4. Martens CR, Seals DR. Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing. J Physiol. 2016 Dec 15; 594(24):7177-7195.
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    5. Gioscia-Ryan RA, Battson ML, Cuevas LM, Zigler MC, Sindler AL, Seals DR. Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice. Aging (Albany NY). 2016 Nov 22; 8(11):2897-2914.
      View in: PubMed
    6. Santos-Parker JR, Strahler TR, Vorwald VM, Pierce GL, Seals DR. Habitual aerobic exercise does not protect against micro- or macrovascular endothelial dysfunction in healthy estrogen-deficient postmenopausal women. J Appl Physiol (1985). 2017 Jan 01; 122(1):11-19.
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    7. LaRocca TJ, Martens CR, Seals DR. Nutrition and other lifestyle influences on arterial aging. Ageing Res Rev. 2016 Sep 28.
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    8. Lesniewski LA, Seals DR, Walker AE, Henson GD, Blimline MW, Trott DW, Bosshardt GC, LaRocca TJ, Lawson BR, Zigler MC, Donato AJ. Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways. Aging Cell. 2017 Feb; 16(1):17-26.
      View in: PubMed
    9. Jalal DI, Decker E, Perrenoud L, Nowak KL, Bispham N, Mehta T, Smits G, You Z, Seals D, Chonchol M, Johnson RJ. Vascular Function and Uric Acid-Lowering in Stage 3 CKD. J Am Soc Nephrol. 2017 Mar; 28(3):943-952.
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    10. LaRocca TJ, Justice JN, Seals DR, Martens CR. Adding value to a graduate physiology seminar by focusing on public communication skills. Adv Physiol Educ. 2016 Sep; 40(3):365-9.
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    11. Kaplon RE, Hill SD, Bispham NZ, Santos-Parker JR, Nowlan MJ, Snyder LL, Chonchol M, LaRocca TJ, McQueen MB, Seals DR. Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults. Aging (Albany NY). 2016 Jun; 8(6):1167-83.
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    12. de Picciotto NE, Gano LB, Johnson LC, Martens CR, Sindler AL, Mills KF, Imai S, Seals DR. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 2016 Jun; 15(3):522-30.
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    13. Pierce GL, Harris SA, Seals DR, Casey DP, Barlow PB, Stauss HM. Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of ageing and habitual endurance exercise. J Hum Hypertens. 2016 Sep; 30(9):513-20.
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    14. Jablonski KL, Donato AJ, Fleenor BS, Nowlan MJ, Walker AE, Kaplon RE, Ballak DB, Seals DR. Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor ? B signalling. J Hypertens. 2015 Dec; 33(12):2477-82.
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    15. DeVan AE, Johnson LC, Brooks FA, Evans TD, Justice JN, Cruickshank-Quinn C, Reisdorph N, Bryan NS, McQueen MB, Santos-Parker JR, Chonchol MB, Bassett CJ, Sindler AL, Giordano T, Seals DR. Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults. J Appl Physiol (1985). 2016 Feb 15; 120(4):416-25.
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    16. Justice JN, Johnson LC, DeVan AE, Cruickshank-Quinn C, Reisdorph N, Bassett CJ, Evans TD, Brooks FA, Bryan NS, Chonchol MB, Giordano T, McQueen MB, Seals DR. Improved motor and cognitive performance with sodium nitrite supplementation is related to small metabolite signatures: a pilot trial in middle-aged and older adults. Aging (Albany NY). 2015 Nov; 7(11):1004-21.
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    17. Justice JN, Cesari M, Seals DR, Shively CA, Carter CS. Comparative Approaches to Understanding the Relation Between Aging and Physical Function. J Gerontol A Biol Sci Med Sci. 2016 Oct; 71(10):1243-53.
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    18. Jablonski KL, Klawitter J, Chonchol M, Bassett CJ, Racine ML, Seals DR. Effect of dietary sodium restriction on human urinary metabolomic profiles. Clin J Am Soc Nephrol. 2015 Jul 07; 10(7):1227-34.
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    19. Seals DR, Justice JN, LaRocca TJ. Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. J Physiol. 2016 Apr 15; 594(8):2001-24.
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    20. Sindler AL, Cox-York K, Reese L, Bryan NS, Seals DR, Gentile CL. Oral nitrite therapy improves vascular function in diabetic mice. Diab Vasc Dis Res. 2015 May; 12(3):221-4.
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    21. Santos-Parker JR, LaRocca TJ, Seals DR. Aerobic exercise and other healthy lifestyle factors that influence vascular aging. Adv Physiol Educ. 2014 Dec; 38(4):296-307.
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    22. Walker AE, Kaplon RE, Pierce GL, Nowlan MJ, Seals DR. Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor ?B. Clin Sci (Lond). 2014 Dec; 127(11):645-54.
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    23. Justice JN, Gioscia-Ryan RA, Johnson LC, Battson ML, de Picciotto NE, Beck HJ, Jiang H, Sindler AL, Bryan NS, Enoka RM, Seals DR. Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice. J Appl Physiol (1985). 2015 Jan 15; 118(2):163-9.
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    24. Gano LB, Donato AJ, Pasha HM, Hearon CM, Sindler AL, Seals DR. The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice. Am J Physiol Heart Circ Physiol. 2014 Dec 15; 307(12):H1754-63.
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    25. Seals DR, Melov S. Translational geroscience: emphasizing function to achieve optimal longevity. Aging (Albany NY). 2014 Sep; 6(9):718-30.
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    26. Fontana L, Kennedy BK, Longo VD, Seals D, Melov S. Medical research: treat ageing. Nature. 2014 Jul 24; 511(7510):405-7.
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    27. LaRocca TJ, Hearon CM, Henson GD, Seals DR. Mitochondrial quality control and age-associated arterial stiffening. Exp Gerontol. 2014 Oct; 58:78-82.
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    28. Seals DR, Kaplon RE, Gioscia-Ryan RA, LaRocca TJ. You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology (Bethesda). 2014 Jul; 29(4):250-64.
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    29. Jablonski KL, Decker E, Perrenoud L, Kendrick J, Chonchol M, Seals DR, Jalal D. Assessment of vascular function in patients with chronic kidney disease. J Vis Exp. 2014 Jun 16; (88).
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    30. Seals DR. Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries. J Appl Physiol (1985). 2014 Sep 01; 117(5):425-39.
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    31. Justice JN, Carter CS, Beck HJ, Gioscia-Ryan RA, McQueen M, Enoka RM, Seals DR. Battery of behavioral tests in mice that models age-associated changes in human motor function. Age (Dordr). 2014 Apr; 36(2):583-92.
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    32. Gioscia-Ryan RA, LaRocca TJ, Sindler AL, Zigler MC, Murphy MP, Seals DR. Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice. J Physiol. 2014 Jun 15; 592(12):2549-61.
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    33. Fleenor BS, Eng JS, Sindler AL, Pham BT, Kloor JD, Seals DR. Superoxide signaling in perivascular adipose tissue promotes age-related artery stiffness. Aging Cell. 2014 Jun; 13(3):576-8.
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    34. Sindler AL, Devan AE, Fleenor BS, Seals DR. Inorganic nitrite supplementation for healthy arterial aging. J Appl Physiol (1985). 2014 Mar 01; 116(5):463-77.
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    35. Kaplon RE, Gano LB, Seals DR. Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults. J Appl Physiol (1985). 2014 Jan 15; 116(2):156-63.
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    36. Moreau KL, Stauffer BL, Kohrt WM, Seals DR. Essential role of estrogen for improvements in vascular endothelial function with endurance exercise in postmenopausal women. J Clin Endocrinol Metab. 2013 Nov; 98(11):4507-15.
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    37. Lesniewski LA, Zigler ML, Durrant JR, Nowlan MJ, Folian BJ, Donato AJ, Seals DR. Aging compounds western diet-associated large artery endothelial dysfunction in mice: prevention by voluntary aerobic exercise. Exp Gerontol. 2013 Nov; 48(11):1218-25.
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    38. Jablonski KL, Fedorova OV, Racine ML, Geolfos CJ, Gates PE, Chonchol M, Fleenor BS, Lakatta EG, Bagrov AY, Seals DR. Dietary sodium restriction and association with urinary marinobufagenin, blood pressure, and aortic stiffness. Clin J Am Soc Nephrol. 2013 Nov; 8(11):1952-9.
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    39. Kaplon RE, Chung E, Reese L, Cox-York K, Seals DR, Gentile CL. Activation of the unfolded protein response in vascular endothelial cells of nondiabetic obese adults. J Clin Endocrinol Metab. 2013 Sep; 98(9):E1505-9.
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    40. Donato AJ, Walker AE, Magerko KA, Bramwell RC, Black AD, Henson GD, Lawson BR, Lesniewski LA, Seals DR. Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice. Aging Cell. 2013 Oct; 12(5):772-83.
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    41. Seals DR. Translational physiology: from molecules to public health. J Physiol. 2013 Jul 15; 591(14):3457-69.
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    42. Walker AE, Kaplon RE, Lucking SM, Russell-Nowlan MJ, Seals DR. Response to effect of fenofibrate on vascular endothelial function: statistical appraisal and its validity. Hypertension. 2013 Jun; 61(6):e56.
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    43. Pierce GL, Casey DP, Fiedorowicz JG, Seals DR, Curry TB, Barnes JN, Wilson DR, Stauss HM. Aortic pulse wave velocity and reflecting distance estimation from peripheral waveforms in humans: detection of age- and exercise training-related differences. Am J Physiol Heart Circ Physiol. 2013 Jul 01; 305(1):H135-42.
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    44. LaRocca TJ, Gioscia-Ryan RA, Hearon CM, Seals DR. The autophagy enhancer spermidine reverses arterial aging. Mech Ageing Dev. 2013 Jul-Aug; 134(7-8):314-20.
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    45. DeVan AE, Pierce GL, Brooks FA, Seals DR. The dependence of FMD% on baseline diameter: a problem solved by allometric scaling - no problem in this case. Clin Sci (Lond). 2013 Mar 13; 125(1):55-6.
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    46. DeVan AE, Eskurza I, Pierce GL, Walker AE, Jablonski KL, Kaplon RE, Seals DR. Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging. Clin Sci (Lond). 2013 Mar; 124(5):325-31.
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    47. Jablonski KL, Racine ML, Geolfos CJ, Gates PE, Chonchol M, McQueen MB, Seals DR. Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure. J Am Coll Cardiol. 2013 Jan 22; 61(3):335-43.
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    48. Fleenor BS, Sindler AL, Marvi NK, Howell KL, Zigler ML, Yoshizawa M, Seals DR. Curcumin ameliorates arterial dysfunction and oxidative stress with aging. Exp Gerontol. 2013 Feb; 48(2):269-76.
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    49. Walker AE, Kaplon RE, Lucking SM, Russell-Nowlan MJ, Eckel RH, Seals DR. Fenofibrate improves vascular endothelial function by reducing oxidative stress while increasing endothelial nitric oxide synthase in healthy normolipidemic older adults. Hypertension. 2012 Dec; 60(6):1517-23.
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    50. Gavin KM, Jankowski C, Kohrt WM, Stauffer BL, Seals DR, Moreau KL. Hysterectomy is associated with large artery stiffening in estrogen-deficient postmenopausal women. Menopause. 2012 Sep; 19(9):1000-7.
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    51. Christou DD, Pierce GL, Walker AE, Hwang MH, Yoo JK, Luttrell M, Meade TH, English M, Seals DR. Vascular smooth muscle responsiveness to nitric oxide is reduced in healthy adults with increased adiposity. Am J Physiol Heart Circ Physiol. 2012 Sep 15; 303(6):H743-50.
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    52. Pierce GL, Jablonski KL, Walker AE, Seibert SM, DeVan AE, Black SM, Sharma S, Seals DR. Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study. Am J Hypertens. 2012 Oct; 25(10):1050-4.
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    53. Fleenor BS, Sindler AL, Eng JS, Nair DP, Dodson RB, Seals DR. Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products. Exp Gerontol. 2012 Aug; 47(8):588-94.
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    54. LaRocca TJ, Henson GD, Thorburn A, Sindler AL, Pierce GL, Seals DR. Translational evidence that impaired autophagy contributes to arterial ageing. J Physiol. 2012 Jul 15; 590(14):3305-16.
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    55. Lesniewski LA, Zigler MC, Durrant JR, Donato AJ, Seals DR. Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism. Mech Ageing Dev. 2012 May; 133(5):368-71.
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    56. DeVan AE, Seals DR. Vascular health in the ageing athlete. Exp Physiol. 2012 Mar; 97(3):305-10.
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    57. Fleenor BS, Seals DR, Zigler ML, Sindler AL. Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice. Aging Cell. 2012 Apr; 11(2):269-76.
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    58. Jalal DI, Jablonski KL, McFann K, Chonchol MB, Seals DR. Vascular endothelial function is not related to serum uric acid in healthy adults. Am J Hypertens. 2012 Apr; 25(4):407-13.
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    59. Pierce GL, Donato AJ, LaRocca TJ, Eskurza I, Silver AE, Seals DR. Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress. Aging Cell. 2011 Dec; 10(6):1032-7.
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    60. Rippe C, Blimline M, Magerko KA, Lawson BR, LaRocca TJ, Donato AJ, Seals DR. MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation. Exp Gerontol. 2012 Jan; 47(1):45-51.
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    61. Fleenor BS, Marshall KD, Rippe C, Seals DR. Replicative aging induces endothelial to mesenchymal transition in human aortic endothelial cells: potential role of inflammation. J Vasc Res. 2012; 49(1):59-64.
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    62. Kaplon RE, Walker AE, Seals DR. Plasma norepinephrine is an independent predictor of vascular endothelial function with aging in healthy women. J Appl Physiol (1985). 2011 Nov; 111(5):1416-21.
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    63. Donato AJ, Magerko KA, Lawson BR, Durrant JR, Lesniewski LA, Seals DR. SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans. J Physiol. 2011 Sep 15; 589(Pt 18):4545-54.
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    64. Lesniewski LA, Durrant JR, Connell ML, Henson GD, Black AD, Donato AJ, Seals DR. Aerobic exercise reverses arterial inflammation with aging in mice. Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H1025-32.
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    65. Gano LB, Donato AJ, Pierce GL, Pasha HM, Magerko KA, Roeca C, Seals DR. Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise. Physiol Genomics. 2011 Jul 27; 43(14):895-902.
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    66. Seals DR, Jablonski KL, Donato AJ. Aging and vascular endothelial function in humans. Clin Sci (Lond). 2011 May; 120(9):357-75.
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    67. Calvert JW, Condit ME, Aragón JP, Nicholson CK, Moody BF, Hood RL, Sindler AL, Gundewar S, Seals DR, Barouch LA, Lefer DJ. Exercise protects against myocardial ischemia-reperfusion injury via stimulation of ß(3)-adrenergic receptors and increased nitric oxide signaling: role of nitrite and nitrosothiols. Circ Res. 2011 Jun 10; 108(12):1448-58.
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    68. Sindler AL, Fleenor BS, Calvert JW, Marshall KD, Zigler ML, Lefer DJ, Seals DR. Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging. Aging Cell. 2011 Jun; 10(3):429-37.
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    69. Lesniewski LA, Durrant JR, Connell ML, Folian BJ, Donato AJ, Seals DR. Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor kappaB and forkhead Box O phosphorylation. J Gerontol A Biol Sci Med Sci. 2011 Apr; 66(4):409-18.
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    70. Appel LJ, Frohlich ED, Hall JE, Pearson TA, Sacco RL, Seals DR, Sacks FM, Smith SC, Vafiadis DK, Van Horn LV. The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association. Circulation. 2011 Mar 15; 123(10):1138-43.
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    71. Pierce GL, Eskurza I, Walker AE, Fay TN, Seals DR. Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults. Clin Sci (Lond). 2011 Jan; 120(1):13-23.
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    72. Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension. 2011 Jan; 57(1):63-9.
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    73. Fleenor BS, Marshall KD, Durrant JR, Lesniewski LA, Seals DR. Arterial stiffening with ageing is associated with transforming growth factor-ß1-related changes in adventitial collagen: reversal by aerobic exercise. J Physiol. 2010 Oct 15; 588(Pt 20):3971-82.
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    74. Edwards AG, Donato AJ, Lesniewski LA, Gioscia RA, Seals DR, Moore RL. Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK. Mech Ageing Dev. 2010 Nov-Dec; 131(11-12):739-42.
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    75. Rippe C, Lesniewski L, Connell M, LaRocca T, Donato A, Seals D. Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress. Aging Cell. 2010 Jun; 9(3):304-12.
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    76. LaRocca TJ, Seals DR, Pierce GL. Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity. Mech Ageing Dev. 2010 Feb; 131(2):165-7.
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    77. Walker AE, Seibert SM, Donato AJ, Pierce GL, Seals DR. Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults. Hypertension. 2010 Feb; 55(2):363-9.
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    78. Seals DR, Walker AE, Pierce GL, Lesniewski LA. Habitual exercise and vascular ageing. J Physiol. 2009 Dec 01; 587(Pt 23):5541-9.
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    79. Jablonski KL, Gates PE, Pierce GL, Seals DR. Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure. Ther Adv Cardiovasc Dis. 2009 Oct; 3(5):347-56.
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    80. Donato AJ, Pierce GL, Lesniewski LA, Seals DR. Role of NFkappaB in age-related vascular endothelial dysfunction in humans. Aging (Albany NY). 2009 Aug 10; 1(8):678-80.
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    81. Silver AE, Christou DD, Donato AJ, Beske SD, Moreau KL, Magerko KA, Seals DR. Protein expression in vascular endothelial cells obtained from human peripheral arteries and veins. J Vasc Res. 2010; 47(1):1-8.
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    82. Gavin KM, Seals DR, Silver AE, Moreau KL. Vascular endothelial estrogen receptor alpha is modulated by estrogen status and related to endothelial function and endothelial nitric oxide synthase in healthy women. J Clin Endocrinol Metab. 2009 Sep; 94(9):3513-20.
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    83. Donato AJ, Gano LB, Eskurza I, Silver AE, Gates PE, Jablonski K, Seals DR. Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H425-32.
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    84. Durrant JR, Seals DR, Connell ML, Russell MJ, Lawson BR, Folian BJ, Donato AJ, Lesniewski LA. Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase. J Physiol. 2009 Jul 01; 587(Pt 13):3271-85.
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    85. Pierce GL, Lesniewski LA, Lawson BR, Beske SD, Seals DR. Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation. 2009 Mar 10; 119(9):1284-92.
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    86. Lesniewski LA, Connell ML, Durrant JR, Folian BJ, Anderson MC, Donato AJ, Seals DR. B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging. J Gerontol A Biol Sci Med Sci. 2009 Jan; 64(1):9-20.
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    87. Walker AE, Eskurza I, Pierce GL, Gates PE, Seals DR. Modulation of vascular endothelial function by low-density lipoprotein cholesterol with aging: influence of habitual exercise. Am J Hypertens. 2009 Mar; 22(3):250-6.
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    88. Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR. Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell. 2008 Dec; 7(6):805-12.
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    89. Donato AJ, Eskurza I, Jablonski KL, Gano LB, Pierce GL, Seals DR. Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans. J Appl Physiol (1985). 2008 Oct; 105(4):1359-63.
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    90. Seals DR, Desouza CA, Donato AJ, Tanaka H. Habitual exercise and arterial aging. J Appl Physiol (1985). 2008 Oct; 105(4):1323-32.
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    91. Pierce GL, Beske SD, Lawson BR, Southall KL, Benay FJ, Donato AJ, Seals DR. Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults. Hypertension. 2008 Jul; 52(1):72-9.
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    92. Christou DD, Seals DR. Decreased maximal heart rate with aging is related to reduced {beta}-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate. J Appl Physiol (1985). 2008 Jul; 105(1):24-9.
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    93. Jablonski KL, Seals DR, Eskurza I, Monahan KD, Donato AJ. High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men. J Appl Physiol (1985). 2007 Nov; 103(5):1715-21.
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    94. Tanaka H, Seals DR. Endurance exercise performance in Masters athletes: age-associated changes and underlying physiological mechanisms. J Physiol. 2008 Jan 01; 586(1):55-63.
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    95. Stob NR, Seals DR, Jørgen J, van Baak MA, Steig AJ, Lindstrom RC, Bikman BT, Bell C. Increased thermogenic responsiveness to intravenous beta-adrenergic stimulation in habitually exercising humans is not related to skeletal muscle beta2-adrenergic receptor density. Exp Physiol. 2007 Sep; 92(5):823-30.
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    96. Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ Res. 2007 Jun 08; 100(11):1659-66.
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    97. Stob NR, Bell C, van Baak MA, Seals DR. Thermic effect of food and beta-adrenergic thermogenic responsiveness in habitually exercising and sedentary healthy adult humans. J Appl Physiol (1985). 2007 Aug; 103(2):616-22.
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    98. Seals DR, Donato AJ, Pierce GL, Walker AE. Commentary on Viewpoint "Human experimentation: no accurate, quantitative data?". J Appl Physiol (1985). 2007 Mar; 102(3):1294.
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    99. Silver AE, Beske SD, Christou DD, Donato AJ, Moreau KL, Eskurza I, Gates PE, Seals DR. Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress. Circulation. 2007 Feb 06; 115(5):627-37.
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    100. Bryan A, Hutchison KE, Seals DR, Allen DL. A transdisciplinary model integrating genetic, physiological, and psychological correlates of voluntary exercise. Health Psychol. 2007 Jan; 26(1):30-9.
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    101. Moreau KL, DePaulis AR, Gavin KM, Seals DR. Oxidative stress contributes to chronic leg vasoconstriction in estrogen-deficient postmenopausal women. J Appl Physiol (1985). 2007 Mar; 102(3):890-5.
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    102. Moreau KL, Gavin KM, Plum AE, Seals DR. Oxidative stress explains differences in large elastic artery compliance between sedentary and habitually exercising postmenopausal women. Menopause. 2006 Nov-Dec; 13(6):951-8.
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    103. Moreau KL, Silver AE, Dinenno FA, Seals DR. Habitual aerobic exercise is associated with smaller femoral artery intima-media thickness with age in healthy men and women. Eur J Cardiovasc Prev Rehabil. 2006 Oct; 13(5):805-11.
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    104. Gates PE, Seals DR. Decline in large elastic artery compliance with age: a therapeutic target for habitual exercise. Br J Sports Med. 2006 Nov; 40(11):897-9.
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    105. Gates PE, Boucher ML, Silver AE, Monahan KD, Seals DR. Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression. J Appl Physiol (1985). 2007 Jan; 102(1):63-71.
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    106. Seals DR, Moreau KL, Gates PE, Eskurza I. Modulatory influences on ageing of the vasculature in healthy humans. Exp Gerontol. 2006 May; 41(5):501-7.
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    107. Eskurza I, Kahn ZD, Seals DR. Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing. J Physiol. 2006 Mar 15; 571(Pt 3):661-8.
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    108. Kukielka M, Seals DR, Billman GE. Cardiac vagal modulation of heart rate during prolonged submaximal exercise in animals with healed myocardial infarctions: effects of training. Am J Physiol Heart Circ Physiol. 2006 Apr; 290(4):H1680-5.
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    109. Bell C, Stob NR, Seals DR. Thermogenic responsiveness to beta-adrenergic stimulation is augmented in exercising versus sedentary adults: role of oxidative stress. J Physiol. 2006 Feb 01; 570(Pt 3):629-35.
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    110. Bell C, Stob NR, Seals DR. Thermogenic responsiveness to nonspecific beta-adrenergic stimulation is not related to genetic variation in codon 16 of the beta2-adrenergic receptor. Am J Physiol Endocrinol Metab. 2006 Apr; 290(4):E703-7.
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    111. Eskurza I, Myerburgh LA, Kahn ZD, Seals DR. Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J Physiol. 2005 Nov 01; 568(Pt 3):1057-65.
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    112. Mazzaro L, Almasi SJ, Shandas R, Seals DR, Gates PE. Aortic input impedance increases with age in healthy men and women. Hypertension. 2005 Jun; 45(6):1101-6.
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    113. Moreau KL, Gavin KM, Plum AE, Seals DR. Ascorbic acid selectively improves large elastic artery compliance in postmenopausal women. Hypertension. 2005 Jun; 45(6):1107-12.
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    114. Christou DD, Gentile CL, DeSouza CA, Seals DR, Gates PE. Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men. Circulation. 2005 Apr 19; 111(15):1904-14.
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    115. Christou DD, Jones PP, Jordan J, Diedrich A, Robertson D, Seals DR. Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men. Circulation. 2005 Feb 01; 111(4):494-8.
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    116. Seals DR, Gates PE. Stiffening our resolve against adult weight gain. Hypertension. 2005 Feb; 45(2):175-7.
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    117. Seals DR, Dinenno FA. Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1895-905.
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    118. Bell C, Carson JM, Motte NW, Seals DR. Ascorbic acid does not affect the age-associated reduction in maximal cardiac output and oxygen consumption in healthy adults. J Appl Physiol (1985). 2005 Mar; 98(3):845-9.
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    119. Jones PP, Van Pelt RE, Johnson DG, Seals DR. Role of sympathetic neural activation in age- and habitual exercise-related differences in the thermic effect of food. J Clin Endocrinol Metab. 2004 Oct; 89(10):5138-44.
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    120. Bell C, Day DS, Jones PP, Christou DD, Petitt DS, Osterberg K, Melby CL, Seals DR. High energy flux mediates the tonically augmented beta-adrenergic support of resting metabolic rate in habitually exercising older adults. J Clin Endocrinol Metab. 2004 Jul; 89(7):3573-8.
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    121. Christou DD, Jones PP, Pimentel AE, Seals DR. Increased abdominal-to-peripheral fat distribution contributes to altered autonomic-circulatory control with human aging. Am J Physiol Heart Circ Physiol. 2004 Oct; 287(4):H1530-7.
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    122. Gates PE, Tanaka H, Hiatt WR, Seals DR. Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension. Hypertension. 2004 Jul; 44(1):35-41.
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    123. Eskurza I, Monahan KD, Robinson JA, Seals DR. Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men. Am J Physiol Heart Circ Physiol. 2004 Apr; 286(4):H1528-34.
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    124. Monahan KD, Eskurza I, Seals DR. Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2113-7.
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    125. Seals DR, Bell C. Chronic sympathetic activation: consequence and cause of age-associated obesity? Diabetes. 2004 Feb; 53(2):276-84.
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    126. Eskurza I, Monahan KD, Robinson JA, Seals DR. Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing. J Physiol. 2004 Apr 01; 556(Pt 1):315-24.
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    127. Gates PE, Tanaka H, Graves J, Seals DR. Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness. Eur Heart J. 2003 Dec; 24(24):2213-20.
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    128. Tanaka H, Seals DR. Invited Review: Dynamic exercise performance in Masters athletes: insight into the effects of primary human aging on physiological functional capacity. J Appl Physiol (1985). 2003 Nov; 95(5):2152-62.
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    129. Bell C, Petitt DS, Jones PP, Seals DR. Influence of adiposity on tonic sympathetic support of resting metabolism in healthy adults. Int J Obes Relat Metab Disord. 2003 Nov; 27(11):1315-8.
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    130. Gates PE, Gentile CL, Seals DR, Christou DD. Adiposity contributes to differences in left ventricular structure and diastolic function with age in healthy men. J Clin Endocrinol Metab. 2003 Oct; 88(10):4884-90.
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    131. Bell C, Jones PP, Seals DR. Oxidative stress does not modulate metabolic rate or skeletal muscle sympathetic activity with primary aging in adult humans. J Clin Endocrinol Metab. 2003 Oct; 88(10):4950-4.
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    132. Christou DD, Jones PP, Seals DR. Baroreflex buffering in sedentary and endurance exercise-trained healthy men. Hypertension. 2003 Jun; 41(6):1219-22.
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    133. Seals DR. Habitual exercise and the age-associated decline in large artery compliance. Exerc Sport Sci Rev. 2003 Apr; 31(2):68-72.
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    134. Jones PP, Christou DD, Jordan J, Seals DR. Baroreflex buffering is reduced with age in healthy men. Circulation. 2003 Apr 08; 107(13):1770-4.
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    135. Moreau KL, Donato AJ, Seals DR, DeSouza CA, Tanaka H. Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovasc Res. 2003 Mar; 57(3):861-8.
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    136. Pimentel AE, Gentile CL, Tanaka H, Seals DR, Gates PE. Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men. J Appl Physiol (1985). 2003 Jun; 94(6):2406-13.
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    137. Bell C, Monahan KD, Donato AJ, Hunt BE, Seals DR, Beck KC. Use of acetylene breathing to determine cardiac output in young and older adults. Med Sci Sports Exerc. 2003 Jan; 35(1):58-64.
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    138. Moreau KL, Donato AJ, Tanaka H, Jones PP, Gates PE, Seals DR. Basal leg blood flow in healthy women is related to age and hormone replacement therapy status. J Physiol. 2003 Feb 15; 547(Pt 1):309-16.
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    139. Donato AJ, Tench K, Glueck DH, Seals DR, Eskurza I, Tanaka H. Declines in physiological functional capacity with age: a longitudinal study in peak swimming performance. J Appl Physiol (1985). 2003 Feb; 94(2):764-9.
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    140. Clevenger CM, Parker Jones P, Tanaka H, Seals DR, DeSouza CA. Decline in insulin action with age in endurance-trained humans. J Appl Physiol (1985). 2002 Dec; 93(6):2105-11.
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    141. Moreau KL, Donato AJ, Seals DR, Dinenno FA, Blackett SD, Hoetzer GL, Desouza CA, Tanaka H. Arterial intima-media thickness: site-specific associations with HRT and habitual exercise. Am J Physiol Heart Circ Physiol. 2002 Oct; 283(4):H1409-17.
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    142. Eskurza I, Donato AJ, Moreau KL, Seals DR, Tanaka H. Changes in maximal aerobic capacity with age in endurance-trained women: 7-yr follow-up. J Appl Physiol (1985). 2002 Jun; 92(6):2303-8.
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    143. Jones PP, Shapiro LF, Keisling GA, Quaife RA, Seals DR. Is autonomic support of arterial blood pressure related to habitual exercise status in healthy men? J Physiol. 2002 Apr 15; 540(Pt 2):701-6.
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    144. Tanaka H, Seals DR, Monahan KD, Clevenger CM, DeSouza CA, Dinenno FA. Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men. J Appl Physiol (1985). 2002 Apr; 92(4):1458-64.
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    145. Esler M, Hastings J, Lambert G, Kaye D, Jennings G, Seals DR. The influence of aging on the human sympathetic nervous system and brain norepinephrine turnover. Am J Physiol Regul Integr Comp Physiol. 2002 Mar; 282(3):R909-16.
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    146. Esler M, Lambert G, Kaye D, Rumantir M, Hastings J, Seals DR. Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress. Biogerontology. 2002; 3(1-2):45-9.
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    147. Seals DR, Monahan KD, Bell C, Tanaka H, Jones PP. The aging cardiovascular system: changes in autonomic function at rest and in response to exercise. Int J Sport Nutr Exerc Metab. 2001 Dec; 11 Suppl:S189-95.
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    148. Seals DR. Robin Hood for the lungs? A respiratory metaboreflex that "steals" blood flow from locomotor muscles. J Physiol. 2001 Nov 15; 537(Pt 1):2.
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    149. Jones PP, Shapiro LF, Keisling GA, Jordan J, Shannon JR, Quaife RA, Seals DR. Altered autonomic support of arterial blood pressure with age in healthy men. Circulation. 2001 Nov 13; 104(20):2424-9.
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    150. Eskurza I, Seals DR, DeSouza CA, Tanaka H. Pharmacologic versus flow-mediated assessments of peripheral vascular endothelial vasodilatory function in humans. Am J Cardiol. 2001 Nov 01; 88(9):1067-9.
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    151. Dinenno FA, Tanaka H, Stauffer BL, Seals DR. Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction. J Physiol. 2001 Nov 01; 536(Pt 3):977-83.
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    152. Monahan KD, Tanaka H, Dinenno FA, Seals DR. Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity. Circulation. 2001 Oct 02; 104(14):1627-32.
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    153. Bell C, Seals DR, Monroe MB, Day DS, Shapiro LF, Johnson DG, Jones PP. Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults. J Clin Endocrinol Metab. 2001 Sep; 86(9):4440-4.
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    154. van Pelt RE, Dinneno FA, Seals DR, Jones PP. Age-related decline in RMR in physically active men: relation to exercise volume and energy intake. Am J Physiol Endocrinol Metab. 2001 Sep; 281(3):E633-9.
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    155. Schiller BC, Casas YG, Desouza CA, Seals DR. Maximal aerobic capacity across age in healthy Hispanic and Caucasian women. J Appl Physiol (1985). 2001 Sep; 91(3):1048-54.
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    156. Monahan KD, Dinenno FA, Seals DR, Halliwill JR. Smaller age-associated reductions in leg venous compliance in endurance exercise-trained men. Am J Physiol Heart Circ Physiol. 2001 Sep; 281(3):H1267-73.
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    157. Seals DR, Tanaka H, Clevenger CM, Monahan KD, Reiling MJ, Hiatt WR, Davy KP, DeSouza CA. Blood pressure reductions with exercise and sodium restriction in postmenopausal women with elevated systolic pressure: role of arterial stiffness. J Am Coll Cardiol. 2001 Aug; 38(2):506-13.
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    158. Monahan KD, Dinenno FA, Seals DR, Clevenger CM, Desouza CA, Tanaka H. Age-associated changes in cardiovagal baroreflex sensitivity are related to central arterial compliance. Am J Physiol Heart Circ Physiol. 2001 Jul; 281(1):H284-9.
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    159. Dinenno FA, Tanaka H, Monahan KD, Clevenger CM, Eskurza I, DeSouza CA, Seals DR. Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. J Physiol. 2001 Jul 01; 534(Pt 1):287-95.
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    160. Monroe MB, Seals DR, Shapiro LF, Bell C, Johnson D, Parker Jones P. Direct evidence for tonic sympathetic support of resting metabolic rate in healthy adult humans. Am J Physiol Endocrinol Metab. 2001 May; 280(5):E740-4.
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    161. Dinenno FA, Seals DR, DeSouza CA, Tanaka H. Age-related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects. J Physiol. 2001 Mar 01; 531(Pt 2):573-9.
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    162. Tanaka H, Dinenno FA, Monahan KD, DeSouza CA, Seals DR. Carotid artery wall hypertrophy with age is related to local systolic blood pressure in healthy men. Arterioscler Thromb Vasc Biol. 2001 Jan; 21(1):82-7.
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    163. Tanaka H, Monahan KD, Seals DR. Age-predicted maximal heart rate revisited. J Am Coll Cardiol. 2001 Jan; 37(1):153-6.
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    164. Casas YG, Schiller BC, DeSouza CA, Seals DR. Total and regional body composition across age in healthy Hispanic and white women of similar socioeconomic status. Am J Clin Nutr. 2001 Jan; 73(1):13-8.
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    165. Schiller BC, Casas YG, Tracy BL, DeSouza CA, Seals DR. Age-related declines in knee extensor strength and physical performance in healthy Hispanic and Caucasian women. J Gerontol A Biol Sci Med Sci. 2000 Dec; 55(12):B563-9.
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    166. Monahan KD, Dinenno FA, Tanaka H, Clevenger CM, DeSouza CA, Seals DR. Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men. J Physiol. 2000 Nov 15; 529 Pt 1:263-71.
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    167. Seals DR, Esler MD. Human ageing and the sympathoadrenal system. J Physiol. 2000 Nov 01; 528(Pt 3):407-17.
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    168. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H, Seals DR. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation. 2000 Sep 19; 102(12):1351-7.
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    169. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR. Aging, habitual exercise, and dynamic arterial compliance. Circulation. 2000 Sep 12; 102(11):1270-5.
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    170. Tanaka H, Dinenno FA, Seals DR. Age-related increase in femoral intima-media thickness in healthy humans. Arterioscler Thromb Vasc Biol. 2000 Sep; 20(9):2172.
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    171. Monroe MB, Van Pelt RE, Schiller BC, Seals DR, Jones PP. Relation of leptin and insulin to adiposity-associated elevations in sympathetic activity with age in humans. Int J Obes Relat Metab Disord. 2000 Sep; 24(9):1183-7.
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    172. Rumantir MS, Jennings GL, Lambert GW, Kaye DM, Seals DR, Esler MD. The 'adrenaline hypothesis' of hypertension revisited: evidence for adrenaline release from the heart of patients with essential hypertension. J Hypertens. 2000 Jun; 18(6):717-23.
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    173. Seals DR, Tanaka H. Manuscript peer review: a helpful checklist for students and novice referees. Adv Physiol Educ. 2000 Jun; 23(1):52-8.
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    174. Dinenno FA, Jones PP, Seals DR, Tanaka H. Age-associated arterial wall thickening is related to elevations in sympathetic activity in healthy humans. Am J Physiol Heart Circ Physiol. 2000 Apr; 278(4):H1205-10.
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    175. Seals DR, Stevenson ET, Jones PP, DeSouza CA, Tanaka H. Lack of age-associated elevations in 24-h systolic and pulse pressures in women who exercise regularly. Am J Physiol. 1999 Sep; 277(3 Pt 2):H947-55.
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    176. Rumantir MS, Vaz M, Jennings GL, Collier G, Kaye DM, Seals DR, Wiesner GH, Brunner-La Rocca HP, Esler MD. Neural mechanisms in human obesity-related hypertension. J Hypertens. 1999 Aug; 17(8):1125-33.
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    177. Dinenno FA, Jones PP, Seals DR, Tanaka H. Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand. Circulation. 1999 Jul 13; 100(2):164-70.
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    178. Wiesner G, Vaz M, Collier G, Seals D, Kaye D, Jennings G, Lambert G, Wilkinson D, Esler M. Leptin is released from the human brain: influence of adiposity and gender. J Clin Endocrinol Metab. 1999 Jul; 84(7):2270-4.
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    179. Jones PP, Davy KP, Seals DR. Influence of gender on the sympathetic neural adjustments to alterations in systemic oxygen levels in humans. Clin Physiol. 1999 Mar; 19(2):153-60.
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    180. Tanaka H, Davy KP, Seals DR. Cardiopulmonary baroreflex inhibition of sympathetic nerve activity is preserved with age in healthy humans. J Physiol. 1999 Feb 15; 515 ( Pt 1):249-54.
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    181. Tanaka H, Dinenno FA, Hunt BE, Jones PP, DeSouza CA, Seals DR. Hemodynamic sequelae of age-related increases in arterial stiffness in healthy women. Am J Cardiol. 1998 Nov 01; 82(9):1152-5, A10.
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    182. Davy KP, Tanaka H, Andros EA, Gerber JG, Seals DR. Influence of age on arterial baroreflex inhibition of sympathetic nerve activity in healthy adult humans. Am J Physiol. 1998 Nov; 275(5 Pt 2):H1768-72.
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    183. Hunt BE, Davy KP, Jones PP, DeSouza CA, Van Pelt RE, Tanaka H, Seals DR. Role of central circulatory factors in the fat-free mass-maximal aerobic capacity relation across age. Am J Physiol. 1998 Oct; 275(4 Pt 2):H1178-82.
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    184. Van Pelt RE, Davy KP, Stevenson ET, Wilson TM, Jones PP, Desouza CA, Seals DR. Smaller differences in total and regional adiposity with age in women who regularly perform endurance exercise. Am J Physiol. 1998 Oct; 275(4 Pt 1):E626-34.
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    185. Tanaka H, DeSouza CA, Seals DR. Arterial stiffness and hormone replacement use in healthy postmenopausal women. J Gerontol A Biol Sci Med Sci. 1998 Sep; 53(5):M344-6.
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    186. Tanaka H, Clevenger CM, Jones PP, Seals DR, DeSouza CA. Influence of body fatness on the coronary risk profile of physically active postmenopausal women. Metabolism. 1998 Sep; 47(9):1112-20.
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    187. Davy KP, Seals DR, Tanaka H. Augmented cardiopulmonary and integrative sympathetic baroreflexes but attenuated peripheral vasoconstriction with age. Hypertension. 1998 Aug; 32(2):298-304.
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    188. Davy KP, DeSouza CA, Jones PP, Seals DR. Elevated heart rate variability in physically active young and older adult women. Clin Sci (Lond). 1998 Jun; 94(6):579-84.
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    189. Taylor JA, Williams TD, Seals DR, Davy KP. Low-frequency arterial pressure fluctuations do not reflect sympathetic outflow: gender and age differences. Am J Physiol. 1998 Apr; 274(4 Pt 2):H1194-201.
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    190. Tanaka H, Reiling MJ, Seals DR. Regular walking increases peak limb vasodilatory capacity of older hypertensive humans: implications for arterial structure. J Hypertens. 1998 Apr; 16(4):423-8.
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    191. Esler M, Vaz M, Collier G, Nestel P, Jennings G, Kaye D, Seals D, Lambert G. Leptin in human plasma is derived in part from the brain, and cleared by the kidneys. Lancet. 1998 Mar 21; 351(9106):879.
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    192. DeSouza CA, Jones PP, Seals DR. Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women. Arterioscler Thromb Vasc Biol. 1998 Mar; 18(3):362-8.
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    193. Tanaka H, DeSouza CA, Seals DR. Absence of age-related increase in central arterial stiffness in physically active women. Arterioscler Thromb Vasc Biol. 1998 Jan; 18(1):127-32.
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    194. Tanaka H, Desouza CA, Jones PP, Stevenson ET, Davy KP, Seals DR. Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women. J Appl Physiol (1985). 1997 Dec; 83(6):1947-53.
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    195. DeSouza CA, Dengel DR, Macko RF, Cox K, Seals DR. Elevated levels of circulating cell adhesion molecules in uncomplicated essential hypertension. Am J Hypertens. 1997 Dec; 10(12 Pt 1):1335-41.
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    196. Stevenson ET, DeSouza CA, Jones PP, Van Pelt RE, Seals DR. Physically active women demonstrate less adverse age-related changes in plasma lipids and lipoproteins. Am J Cardiol. 1997 Nov 15; 80(10):1360-4.
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    197. Jones PP, Davy KP, Seals DR. Relations of total and abdominal adiposity to muscle sympathetic nerve activity in healthy older males. Int J Obes Relat Metab Disord. 1997 Nov; 21(11):1053-7.
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    198. Hunt BE, Davy KP, Seals DR. Reproducibility of a semiautomated acetylene rebreathing technique for measuring cardiac output in humans at rest. Clin Physiol. 1997 Nov; 17(6):599-607.
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    199. Van Pelt RE, Jones PP, Davy KP, Desouza CA, Tanaka H, Davy BM, Seals DR. Regular exercise and the age-related decline in resting metabolic rate in women. J Clin Endocrinol Metab. 1997 Oct; 82(10):3208-12.
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    200. DeSouza CA, Stevenson ET, Davy KP, Jones PP, Seals DR. Plasma fibrinogen levels in healthy postmenopausal women: physical activity and hormone replacement status. J Gerontol A Biol Sci Med Sci. 1997 Sep; 52(5):M294-8.
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    201. Davy KP, Jones PP, Seals DR. Influence of age on the sympathetic neural adjustments to alterations in systemic oxygen levels in humans. Am J Physiol. 1997 Aug; 273(2 Pt 2):R690-5.
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    202. Hunt BE, Davy KP, Jones PP, DeSouza CA, Van Pelt RE, Tanaka H, Seals DR. Systemic hemodynamic determinants of blood pressure in women: age, physical activity, and hormone replacement. Am J Physiol. 1997 Aug; 273(2 Pt 2):H777-85.
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    203. Fitzgerald MD, Tanaka H, Tran ZV, Seals DR. Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary women: a meta-analysis. J Appl Physiol (1985). 1997 Jul; 83(1):160-5.
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    204. Seals DR, Silverman HG, Reiling MJ, Davy KP. Effect of regular aerobic exercise on elevated blood pressure in postmenopausal women. Am J Cardiol. 1997 Jul 01; 80(1):49-55.
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    205. Jones PP, Davy KP, DeSouza CA, van Pelt RE, Seals DR. Absence of age-related decline in total blood volume in physically active females. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2534-40.
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    206. Jones PP, Davy KP, Alexander S, Seals DR. Age-related increase in muscle sympathetic nerve activity is associated with abdominal adiposity. Am J Physiol. 1997 Jun; 272(6 Pt 1):E976-80.
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    207. Tanaka H, Seals DR. Age and gender interactions in physiological functional capacity: insight from swimming performance. J Appl Physiol (1985). 1997 Mar; 82(3):846-51.
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    208. Stevenson ET, Davy KP, Jones PP, Desouza CA, Seals DR. Blood pressure risks factors in healthy postmenopausal women: physical activity and hormone replacement. J Appl Physiol (1985). 1997 Feb; 82(2):652-60.
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    209. Davy KP, Willis WL, Seals DR. Influence of exercise training on heart rate variability in post-menopausal women with elevated arterial blood pressure. Clin Physiol. 1997 Jan; 17(1):31-40.
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    210. Davy KP, Miniclier NL, Taylor JA, Stevenson ET, Seals DR. Elevated heart rate variability in physically active postmenopausal women: a cardioprotective effect? Am J Physiol. 1996 Aug; 271(2 Pt 2):H455-60.
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    211. Davy KP, Evans SL, Stevenson ET, Seals DR. Adiposity and regional body fat distribution in physically active young and middle-aged women. Int J Obes Relat Metab Disord. 1996 Aug; 20(8):777-83.
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    212. Jones PP, Spraul M, Matt KS, Seals DR, Skinner JS, Ravussin E. Gender does not influence sympathetic neural reactivity to stress in healthy humans. Am J Physiol. 1996 Jan; 270(1 Pt 2):H350-7.
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    213. Taylor JA, Hayano J, Seals DR. Lesser vagal withdrawal during isometric exercise with age. J Appl Physiol (1985). 1995 Sep; 79(3):805-11.
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    214. Evans SL, Davy KP, Stevenson ET, Seals DR. Physiological determinants of 10-km performance in highly trained female runners of different ages. J Appl Physiol (1985). 1995 May; 78(5):1931-41.
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    215. Stevenson ET, Davy KP, Seals DR. Hemostatic, metabolic, and androgenic risk factors for coronary heart disease in physically active and less active postmenopausal women. Arterioscler Thromb Vasc Biol. 1995 May; 15(5):669-77.
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    216. Davy KP, Johnson DG, Seals DR. Cardiovascular, plasma norepinephrine, and thermal adjustments to prolonged exercise in young and older healthy humans. Clin Physiol. 1995 Mar; 15(2):169-81.
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    217. Ng AV, Johnson DG, Callister R, Seals DR. Muscle sympathetic nerve activity during postural change in healthy young and older adults. Clin Auton Res. 1995 Feb; 5(1):57-60.
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    218. Esler M, Kaye D, Thompson J, Jennings G, Cox H, Turner A, Lambert G, Seals D. Effects of aging on epinephrine secretion and regional release of epinephrine from the human heart. J Clin Endocrinol Metab. 1995 Feb; 80(2):435-42.
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    219. Esler MD, Thompson JM, Kaye DM, Turner AG, Jennings GL, Cox HS, Lambert GW, Seals DR. Effects of aging on the responsiveness of the human cardiac sympathetic nerves to stressors. Circulation. 1995 Jan 15; 91(2):351-8.
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    220. Esler MD, Turner AG, Kaye DM, Thompson JM, Kingwell BA, Morris M, Lambert GW, Jennings GL, Cox HS, Seals DR. Aging effects on human sympathetic neuronal function. Am J Physiol. 1995 Jan; 268(1 Pt 2):R278-85.
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    221. Stevenson ET, Davy KP, Seals DR. Maximal aerobic capacity and total blood volume in highly trained middle-aged and older female endurance athletes. J Appl Physiol (1985). 1994 Oct; 77(4):1691-6.
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    222. Callister R, Ng AV, Seals DR. Arm muscle sympathetic nerve activity during preparation for and initiation of leg-cycling exercise in humans. J Appl Physiol (1985). 1994 Sep; 77(3):1403-10.
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    223. Ng AV, Callister R, Johnson DG, Seals DR. Endurance exercise training is associated with elevated basal sympathetic nerve activity in healthy older humans. J Appl Physiol (1985). 1994 Sep; 77(3):1366-74.
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    224. Ng AV, Callister R, Johnson DG, Seals DR. Sympathetic neural reactivity to stress does not increase with age in healthy humans. Am J Physiol. 1994 Jul; 267(1 Pt 2):H344-53.
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    225. Seals DR, Taylor JA, Ng AV, Esler MD. Exercise and aging: autonomic control of the circulation. Med Sci Sports Exerc. 1994 May; 26(5):568-76.
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    226. Davy KP, Seals DR. Total blood volume in healthy young and older men. J Appl Physiol (1985). 1994 May; 76(5):2059-62.
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    227. Jasperse JL, Seals DR, Callister R. Active forearm blood flow adjustments to handgrip exercise in young and older healthy men. J Physiol. 1994 Jan 15; 474(2):353-60.
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    228. Seals DR, Hagberg JM, Spina RJ, Rogers MA, Schechtman KB, Ehsani AA. Enhanced left ventricular performance in endurance trained older men. Circulation. 1994 Jan; 89(1):198-205.
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    229. Kenney MJ, Seals DR. Postexercise hypotension. Key features, mechanisms, and clinical significance. Hypertension. 1993 Nov; 22(5):653-64.
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    230. Seals DR. Influence of active muscle size on sympathetic nerve discharge during isometric contractions in humans. J Appl Physiol (1985). 1993 Sep; 75(3):1426-31.
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    231. Fregosi RF, Seals DR. Hypoxic potentiation of the ventilatory response to dynamic forearm exercise. J Appl Physiol (1985). 1993 May; 74(5):2365-72.
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    232. Ng AV, Callister R, Johnson DG, Seals DR. Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension. 1993 Apr; 21(4):498-503.
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    233. Kregel KC, Johnson DG, Seals DR. Tissue-specific noradrenergic activity during acute heat stress in rats. J Appl Physiol (1985). 1993 Apr; 74(4):1988-93.
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    234. Seals DR. Influence of force on muscle and skin sympathetic nerve activity during sustained isometric contractions in humans. J Physiol. 1993 Mar; 462:147-59.
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    235. Seals DR, Suwarno NO, Joyner MJ, Iber C, Copeland JG, Dempsey JA. Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans. Circ Res. 1993 Feb; 72(2):440-54.
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    236. Taylor JA, Hand GA, Johnson DG, Seals DR. Augmented forearm vasoconstriction during dynamic exercise in healthy older men. Circulation. 1992 Dec; 86(6):1789-99.
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    237. Taylor JA, Hand GA, Johnson DG, Seals DR. Sympathoadrenal-circulatory regulation of arterial pressure during orthostatic stress in young and older men. Am J Physiol. 1992 Nov; 263(5 Pt 2):R1147-55.
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    238. Kregel KC, Seals DR, Callister R. Sympathetic nervous system activity during skin cooling in humans: relationship to stimulus intensity and pain sensation. J Physiol. 1992 Aug; 454:359-71.
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    239. Callister R, Suwarno NO, Seals DR. Sympathetic activity is influenced by task difficulty and stress perception during mental challenge in humans. J Physiol. 1992 Aug; 454:373-87.
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    240. Seals DR, Reiling MJ. Effect of regular exercise on 24-hour arterial pressure in older hypertensive humans. Hypertension. 1991 Nov; 18(5):583-92.
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    241. Taylor JA, Hand GA, Johnson DG, Seals DR. Sympathoadrenal-circulatory regulation during sustained isometric exercise in young and older men. Am J Physiol. 1991 Nov; 261(5 Pt 2):R1061-9.
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    242. Seals DR, Johnson DG, Fregosi RF. Hypoxia potentiates exercise-induced sympathetic neural activation in humans. J Appl Physiol (1985). 1991 Sep; 71(3):1032-40.
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    243. Kregel KC, Overton JM, Johnson DG, Tipton CM, Seals DR. Mechanism for pressor response to nonexertional heating in the conscious rat. J Appl Physiol (1985). 1991 Jul; 71(1):192-6.
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    244. Seals DR, Johnson DG, Fregosi RF. Hyperoxia lowers sympathetic activity at rest but not during exercise in humans. Am J Physiol. 1991 May; 260(5 Pt 2):R873-8.
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    245. Overton JM, Kregel KC, Davis-Gorman G, Seals DR, Tipton CM, Fisher LA. Effects of exercise training on responses to central injection of CRF and noise stress. Physiol Behav. 1991 Jan; 49(1):93-8.
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    246. Seals DR. Sympathetic neural adjustments to stress in physically trained and untrained humans. Hypertension. 1991 Jan; 17(1):36-43.
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    247. Seals DR, Victor RG. Regulation of muscle sympathetic nerve activity during exercise in humans. Exerc Sport Sci Rev. 1991; 19:313-49.
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    248. Kregel KC, Johnson DG, Tipton CM, Seals DR. Cardiovascular-sympathetic adjustments to nonexertional heat stress in mature and senescent Fischer 344 rats. J Appl Physiol (1985). 1990 Dec; 69(6):2043-9.
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    249. Rowell LB, Seals DR. Sympathetic activity during graded central hypovolemia in hypoxemic humans. Am J Physiol. 1990 Oct; 259(4 Pt 2):H1197-206.
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    250. Thorén P, Floras JS, Hoffmann P, Seals DR. Endorphins and exercise: physiological mechanisms and clinical implications. Med Sci Sports Exerc. 1990 Aug; 22(4):417-28.
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    251. Seals DR, Suwarno NO, Dempsey JA. Influence of lung volume on sympathetic nerve discharge in normal humans. Circ Res. 1990 Jul; 67(1):130-41.
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    252. Kregel KC, Johnson DG, Tipton CM, Seals DR. Arterial baroreceptor reflex modulation of sympathetic-cardiovascular adjustments to heat stress. Hypertension. 1990 May; 15(5):497-504.
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    253. Kregel KC, Tipton CM, Seals DR. Thermal adjustments to nonexertional heat stress in mature and senescent Fischer 344 rats. J Appl Physiol (1985). 1990 Apr; 68(4):1337-42.
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    254. Joyner MJ, Shepherd JT, Seals DR. Sustained increases in sympathetic outflow during prolonged lower body negative pressure in humans. J Appl Physiol (1985). 1990 Mar; 68(3):1004-9.
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    255. Seals DR. Sympathetic activation during the cold pressor test: influence of stimulus area. Clin Physiol. 1990 Mar; 10(2):123-9.
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    256. Kregel KC, Overton JM, Seals DR, Tipton CM, Fisher LA. Cardiovascular responses to exercise in the rat: role of corticotropin-releasing factor. J Appl Physiol (1985). 1990 Feb; 68(2):561-7.
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    257. Victor RG, Seals DR. Reflex stimulation of sympathetic outflow during rhythmic exercise in humans. Am J Physiol. 1989 Dec; 257(6 Pt 2):H2017-24.
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    258. Seals DR. Influence of muscle mass on sympathetic neural activation during isometric exercise. J Appl Physiol (1985). 1989 Nov; 67(5):1801-6.
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    259. Taylor JA, Joyner MJ, Chase PB, Seals DR. Differential control of forearm and calf vascular resistance during one-leg exercise. J Appl Physiol (1985). 1989 Nov; 67(5):1791-800.
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    260. Floras JS, Sinkey CA, Aylward PE, Seals DR, Thoren PN, Mark AL. Postexercise hypotension and sympathoinhibition in borderline hypertensive men. Hypertension. 1989 Jul; 14(1):28-35.
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    261. Joyner MJ, Chase PB, Allen HD, Seals DR. Response of upper limb blood flow to handgrip exercise after Blalock-Taussig operation (for tetralogy of Fallot) or subclavian flap operation (for aortic isthmic coarctation). Am J Cardiol. 1989 Jun 01; 63(18):1379-84.
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    262. Seals DR. Sympathetic neural discharge and vascular resistance during exercise in humans. J Appl Physiol (1985). 1989 May; 66(5):2472-8.
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    263. Rowell LB, Johnson DG, Chase PB, Comess KA, Seals DR. Hypoxemia raises muscle sympathetic activity but not norepinephrine in resting humans. J Appl Physiol (1985). 1989 Apr; 66(4):1736-43.
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    264. Seals DR, Chase PB. Influence of physical training on heart rate variability and baroreflex circulatory control. J Appl Physiol (1985). 1989 Apr; 66(4):1886-95.
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    265. Seals DR, Enoka RM. Sympathetic activation is associated with increases in EMG during fatiguing exercise. J Appl Physiol (1985). 1989 Jan; 66(1):88-95.
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    266. Nagle FJ, Seals DR, Hanson P. Time to fatigue during isometric exercise using different muscle masses. Int J Sports Med. 1988 Oct; 9(5):313-5.
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    267. Reiling MJ, Seals DR. Respiratory sinus arrhythmia and carotid baroreflex control of heart rate in endurance athletes and untrained controls. Clin Physiol. 1988 Oct; 8(5):511-9.
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    268. Hagberg JM, Seals DR, Yerg JE, Gavin J, Gingerich R, Premachandra B, Holloszy JO. Metabolic responses to exercise in young and older athletes and sedentary men. J Appl Physiol (1985). 1988 Aug; 65(2):900-8.
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    269. Seals DR, Victor RG, Mark AL. Plasma norepinephrine and muscle sympathetic discharge during rhythmic exercise in humans. J Appl Physiol (1985). 1988 Aug; 65(2):940-4.
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    270. Hagberg JM, Yerg JE, Seals DR. Pulmonary function in young and older athletes and untrained men. J Appl Physiol (1985). 1988 Jul; 65(1):101-5.
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    271. Seals DR. Cardiopulmonary baroreflexes do not modulate exercise-induced sympathoexcitation. J Appl Physiol (1985). 1988 May; 64(5):2197-203.
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    272. Seals DR, Chase PB, Taylor JA. Autonomic mediation of the pressor responses to isometric exercise in humans. J Appl Physiol (1985). 1988 May; 64(5):2190-6.
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    273. Seals DR, Rogers MA, Hagberg JM, Yamamoto C, Cryer PE, Ehsani AA. Left ventricular dysfunction after prolonged strenuous exercise in healthy subjects. Am J Cardiol. 1988 Apr 15; 61(11):875-9.
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    274. Hurley BF, Hagberg JM, Goldberg AP, Seals DR, Ehsani AA, Brennan RE, Holloszy JO. Resistive training can reduce coronary risk factors without altering VO2max or percent body fat. Med Sci Sports Exerc. 1988 Apr; 20(2):150-4.
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    275. Taylor JA, Chase PB, Enoka RM, Seals DR. Cardiovascular adjustments to rhythmic handgrip exercise: relationship to electromyographic activity and post-exercise hyperemia. Eur J Appl Physiol Occup Physiol. 1988; 58(1-2):32-8.
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    276. Valdes R, Hagberg JM, Vaughan TE, Lau BW, Seals DR, Ehsani AA. Endogenous digoxin-like immunoreactivity in blood is increased during prolonged strenuous exercise. Life Sci. 1988; 42(1):103-10.
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    277. Victor RG, Leimbach WN, Seals DR, Wallin BG, Mark AL. Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension. 1987 May; 9(5):429-36.
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    278. Victor RG, Seals DR, Mark AL. Differential control of heart rate and sympathetic nerve activity during dynamic exercise. Insight from intraneural recordings in humans. J Clin Invest. 1987 Feb; 79(2):508-16.
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    279. Hurley BF, Hagberg JM, Seals DR, Ehsani AA, Goldberg AP, Holloszy JO. Glucose tolerance and lipid-lipoprotein levels in middle-aged powerlifters. Clin Physiol. 1987 Feb; 7(1):11-9.
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    280. Mark AL, Wallin BG, Seals DR, Victor RG. Mechanism of contrasting pressor responses to static and dynamic exercise: new insights from direct intraneural recordings of sympathetic nerve activity in humans. Trans Am Clin Climatol Assoc. 1987; 98:98-104.
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    281. Yerg JE, Seals DR, Hagberg JM, Ehsani AA. Syncope secondary to ventricular asystole in an endurance athlete. Clin Cardiol. 1986 May; 9(5):220-2.
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    282. Hagberg JM, Seals DR. Exercise training and hypertension. Acta Med Scand Suppl. 1986; 711:131-6.
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    283. Seals DR, Hanson PG, Washburn RA, Painter PL, Ward A, Nagle FJ. Cardiovascular response to static contraction in borderline hypertension. Clin Cardiol. 1985 Jun; 8(6):348-52.
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    284. Hagberg JM, Allen WK, Seals DR, Hurley BF, Ehsani AA, Holloszy JO. A hemodynamic comparison of young and older endurance athletes during exercise. J Appl Physiol (1985). 1985 Jun; 58(6):2041-6.
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    285. Allen WK, Seals DR, Hurley BF, Ehsani AA, Hagberg JM. Lactate threshold and distance-running performance in young and older endurance athletes. J Appl Physiol (1985). 1985 Apr; 58(4):1281-4.
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    286. Seals DR, Hurley BF, Hagberg JM, Schultz J, Linder BJ, Natter L, Ehsani AA. Effects of training on systolic time intervals at rest and during isometric exercise in men and women 61 to 64 years old. Am J Cardiol. 1985 Mar 01; 55(6):797-800.
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    287. Yerg JE, Seals DR, Hagberg JM, Holloszy JO. Effect of endurance exercise training on ventilatory function in older individuals. J Appl Physiol (1985). 1985 Mar; 58(3):791-4.
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    288. Seals DR, Hagberg JM, Hurley BF, Ehsani AA, Holloszy JO. Endurance training in older men and women. I. Cardiovascular responses to exercise. J Appl Physiol Respir Environ Exerc Physiol. 1984 Oct; 57(4):1024-9.
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    289. Seals DR, Hurley BF, Schultz J, Hagberg JM. Endurance training in older men and women II. Blood lactate response to submaximal exercise. J Appl Physiol Respir Environ Exerc Physiol. 1984 Oct; 57(4):1030-3.
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    290. Hurley BF, Seals DR, Ehsani AA, Cartier LJ, Dalsky GP, Hagberg JM, Holloszy JO. Effects of high-intensity strength training on cardiovascular function. Med Sci Sports Exerc. 1984 Oct; 16(5):483-8.
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    291. Ehsani AA, Biello D, Seals DR, Austin MB, Schultz J. The effect of left ventricular systolic function on maximal aerobic exercise capacity in asymptomatic patients with coronary artery disease. Circulation. 1984 Oct; 70(4):552-60.
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    292. Seals DR, Hagberg JM, Hurley BF, Ehsani AA, Holloszy JO. Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women. JAMA. 1984 Aug 03; 252(5):645-9.
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    293. Seals DR, Allen WK, Hurley BF, Dalsky GP, Ehsani AA, Hagberg JM. Elevated high-density lipoprotein cholesterol levels in older endurance athletes. Am J Cardiol. 1984 Aug 01; 54(3):390-3.
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    294. Hurley BF, Seals DR, Hagberg JM, Goldberg AC, Ostrove SM, Holloszy JO, Wiest WG, Goldberg AP. High-density-lipoprotein cholesterol in bodybuilders v powerlifters. Negative effects of androgen use. JAMA. 1984 Jul 27; 252(4):507-13.
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    295. Seals DR, Hagberg JM. The effect of exercise training on human hypertension: a review. Med Sci Sports Exerc. 1984 Jun; 16(3):207-15.
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    296. Seals DR, Hagberg JM, Allen WK, Hurley BF, Dalsky GP, Ehsani AA, Holloszy JO. Glucose tolerance in young and older athletes and sedentary men. J Appl Physiol Respir Environ Exerc Physiol. 1984 Jun; 56(6):1521-5.
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    297. Hurley BF, Hagberg JM, Allen WK, Seals DR, Young JC, Cuddihee RW, Holloszy JO. Effect of training on blood lactate levels during submaximal exercise. J Appl Physiol Respir Environ Exerc Physiol. 1984 May; 56(5):1260-4.
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    298. Washburn RA, Seals DR. Peak oxygen uptake during arm cranking for men and women. J Appl Physiol Respir Environ Exerc Physiol. 1984 Apr; 56(4):954-7.
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    299. Seals DR, Sinacore DR, Hurley BF, Nemeth PM, Hagberg JM. Failure of endurance training to alter the cardiovascular response to static contraction. Clin Physiol. 1983 Jun; 3(3):219-26.
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    300. Seals DR, Washburn RA, Hanson PG, Painter PL, Nagle FJ. Similarity of cardiovascular response to upper and lower body static contraction in endurance-trained and untrained males. Int J Sports Med. 1983 May; 4(2):94-6.
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    301. Seals DR, Washburn RA, Hanson PG, Painter PL, Nagle FJ. Increased cardiovascular response to static contraction of larger muscle groups. J Appl Physiol Respir Environ Exerc Physiol. 1983 Feb; 54(2):434-7.
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    302. Washburn RA, Seals DR. Comparison of peak oxygen uptake in arm cranking. Eur J Appl Physiol Occup Physiol. 1983; 51(1):3-6.
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    303. Seals DR, Mullin JP. VO2 max in variable type exercise among well-trained upper body athletes. Res Q Exerc Sport. 1982 Mar; 53(1):58-63.
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