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Clyde J Wright

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    K08HL098562     (WRIGHT, CLYDE JASON)Apr 1, 2010 - Mar 31, 2015
    NIH/NHLBI
    The unique role of IkBa in modulating NF-kB activity in the newborn lung.
    Role: Principal Investigator

    R01HL132941     (WRIGHT, CLYDE JASON)Jan 1, 2017 - Nov 30, 2021
    NIH/NHLBI
    Role of hepatic IkBb-mediated sustained NFkB activation in neonatal lung injury and abnormal development
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ. Macrophage-derived IL-1ß/NF-?B signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018 Apr 11; 9(1):1393. PMID: 29643332.
      View in: PubMed
    2. Sherlock LG, Trumpie A, Hernandez-Lagunas L, McKenna S, Fisher S, Bowler R, Wright CJ, Delaney C, Nozik-Grayck E. Redistribution of Extracellular Superoxide Dismutase Causes Neonatal Pulmonary Vascular Remodeling and PH but Protects Against Experimental Bronchopulmonary Dysplasia. Antioxidants (Basel). 2018 Mar 14; 7(3). PMID: 29538340.
      View in: PubMed
    3. Wright CJ, Sherlock LG, Sahni R, Polin RA. Preventing Continuous Positive Airway Pressure Failure: Evidence-Based and Physiologically Sound Practices from Delivery Room to the Neonatal Intensive Care Unit. Clin Perinatol. 2018 Jun; 45(2):257-271. PMID: 29747887.
      View in: PubMed
    4. Dietz RM, Wright CJ. Oxidative stress diseases unique to the perinatal period: A window into the developing innate immune response. Am J Reprod Immunol. 2018 May; 79(5):e12787. PMID: 29194835.
      View in: PubMed
    5. Rozance PJ, Wright CJ. Preparing for the first breath: in the developing lung, maternal overnutrition takes centre stage. J Physiol. 2017 Nov 01; 595(21):6595-6596. PMID: 28925540.
      View in: PubMed
    6. McKenna S, Butler B, Jatana L, Ghosh S, Wright CJ. Inhibition of I?Bß/NF?B signaling prevents LPS-induced IL1ß expression without increasing apoptosis in the developing mouse lung. Pediatr Res. 2017 Dec; 82(6):1064-1072. PMID: 28753596.
      View in: PubMed
    7. Sherlock LG, Wright CJ. Preventing extubation failure in preterm infants: nasal CPAP remains the standard of care. Acta Paediatr. 2017 Aug; 106(8):1364. PMID: 28370320.
      View in: PubMed
    8. Wright CJ, Norman M, Kirpalani H, Johansson S. EBNEO commentaries in Acta Paediatrica: a new collaboration to advance evidence-based neonatology. Acta Paediatr. 2017 Mar; 106(3):358. PMID: 28186374.
      View in: PubMed
    9. Wright CJ, Polin RA. Noninvasive Support: Does It Really Decrease Bronchopulmonary Dysplasia? Clin Perinatol. 2016 Dec; 43(4):783-798. PMID: 27837759.
      View in: PubMed
    10. Wright CJ, Kirpalani H. When should we start continuous positive airway pressure in the delivery room and how high should we go? Acta Paediatr. 2016 Aug; 105(8):868-70. PMID: 27383516.
      View in: PubMed
    11. McKenna S, Eckman M, Parker A, Bok R, Hurt KJ, Wright CJ. Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NF?B-Dependent Mechanism. J Innate Immun. 2016; 8(4):386-99. PMID: 27160391.
      View in: PubMed
    12. Wright CJ, Polin RA, Kirpalani H. Continuous Positive Airway Pressure to Prevent Neonatal Lung Injury: How Did We Get Here, and How Do We Improve? J Pediatr. 2016 Jun; 173:17-24.e2. PMID: 27025910.
      View in: PubMed
    13. McKenna S, Gossling M, Bugarini A, Hill E, Anderson AL, Rancourt RC, Balasubramaniyan N, El Kasmi KC, Wright CJ. Endotoxemia Induces I?Bß/NF-?B-Dependent Endothelin-1 Expression in Hepatic Macrophages. J Immunol. 2015 Oct 15; 195(8):3866-79. PMID: 26342031; PMCID: PMC4730915 [Available on 10/15/16].
    14. McKenna S, Wright CJ. Inhibiting I?Bß-NF?B signaling attenuates the expression of select pro-inflammatory genes. J Cell Sci. 2015 Jun 01; 128(11):2143-55. PMID: 25908863; PMCID: PMC4457027.
    15. Wright CJ, Permar SR. Preventing postnatal cytomegalovirus infection in the preterm infant: should it be done, can it be done, and at what cost? J Pediatr. 2015 Apr; 166(4):795-8. PMID: 25662832.
      View in: PubMed
    16. McKenna S, Michaelis KA, Agboke F, Liu T, Han K, Yang G, Dennery PA, Wright CJ. Sustained hyperoxia-induced NF-?B activation improves survival and preserves lung development in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15; 306(12):L1078-89. PMID: 24748603; PMCID: PMC4060010.
    17. Michaelis KA, Agboke F, Liu T, Han K, Muthu M, Galambos C, Yang G, Dennery PA, Wright CJ. I?Bß-mediated NF-?B activation confers protection against hyperoxic lung injury. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):429-38. PMID: 24066808; PMCID: PMC3930955.
    18. Stewart MS, Dietz RM, Landman MP, Moulton SL, Wright CJ. Abdominal radiograph with intravesical air and possible small bowel atresia. J Pediatr. 2014 May; 164(5):1238-1238.e1. PMID: 24472230.
      View in: PubMed
    19. Wright CJ, Saugstad OD. OHRP and SUPPORT: lessons in balancing safety and improving the way we care for patients. J Pediatr. 2013 Nov; 163(5):1495-7. PMID: 24050739.
      View in: PubMed
    20. Benjamin J, Wright CJ. Thin catheter surfactant administration during spontaneous breathing in very low birth weight infants is associated with reduced need for mechanical ventilation. J Pediatr. 2013 Sep; 163(3):923-4. PMID: 23973239.
      View in: PubMed
    21. Tang JR, Michaelis KA, Nozik-Grayck E, Seedorf GJ, Hartman-Filson M, Abman SH, Wright CJ. The NF-?B inhibitory proteins I?Ba and I?Bß mediate disparate responses to inflammation in fetal pulmonary endothelial cells. J Immunol. 2013 Mar 15; 190(6):2913-23. PMID: 23418625; PMCID: PMC3594141.
    22. Wright CJ. 50 Years ago in The Journal of Pediatrics: Some aspects of respiratory problems in the newborn: Cook CD. J Pediatric 1962;61:105-10. J Pediatr. 2012 Jul; 161(1):25. PMID: 22726322.
      View in: PubMed
    23. Wright CJ, Agboke F, Muthu M, Michaelis KA, Mundy MA, La P, Yang G, Dennery PA. Nuclear factor-?B (NF-?B) inhibitory protein I?Bß determines apoptotic cell death following exposure to oxidative stress. J Biol Chem. 2012 Feb 24; 287(9):6230-9. PMID: 22223647; PMCID: PMC3307281.
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