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Clyde J Wright

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    K08HL098562     (WRIGHT, CLYDE JASON)Apr 1, 2010 - Mar 31, 2016
    NIH
    The unique role of IkBa in modulating NF-kB activity in the newborn lung.
    Role: Principal Investigator

    R01HL132941     (WRIGHT, CLYDE JASON)Jan 1, 2017 - Nov 30, 2021
    NIH
    Role of hepatic IkBb-mediated sustained NFkB activation in neonatal lung injury and abnormal development
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wright CJ, McKenna S, De Dios R, Boehmer BH, Nguyen L, Ghosh S, Sandoval J, Rozance PJ. Lower threshold to NF?B activity sensitizes murine ß-cells to streptozotocin. J Endocrinol. 2021 05 06; 249(3):163-175. PMID: 33764312.
      View in: PubMed
    2. Dobrinskikh E, Sherlock LG, Orlicky DJ, Zheng L, De Dios R, Balasubramaniyan D, Sizemore T, Butler B, Wright CJ. The developing murine lung is susceptible to acetaminophen toxicity. Am J Physiol Lung Cell Mol Physiol. 2021 05 01; 320(5):L969-L978. PMID: 33759579.
      View in: PubMed
    3. Wright CJ. Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences? J Pediatr. 2021 Aug; 235:264-276.e1. PMID: 33617854.
      View in: PubMed
    4. Shay R, Wright CJ. Can a predictive model for extubation readiness in preterm infants improve rates of successful extubation? Acta Paediatr. 2021 02; 110(2):722-723. PMID: 33118635.
      View in: PubMed
    5. Zarate MA, Nguyen LM, De Dios RK, Zheng L, Wright CJ. Maturation of the Acute Hepatic TLR4/NF-?B Mediated Innate Immune Response Is p65 Dependent in Mice. Front Immunol. 2020; 11:1892. PMID: 32973783.
      View in: PubMed
    6. Wright CJ, Cari EL, Sandoval J, Bales E, Sam PK, Zarate MA, Polotsky AJ, Kallen AN, Johnson J. Control of Murine Primordial Follicle Growth Activation by I?B/NF?B Signaling. Reprod Sci. 2020 11; 27(11):2063-2074. PMID: 32542534.
      View in: PubMed
    7. Zarate MA, Wesolowski SR, Nguyen LM, De Dios RK, Wilkening RB, Rozance PJ, Wright CJ. In utero inflammatory challenge induces an early activation of the hepatic innate immune response in late gestation fetal sheep. Innate Immun. 2020 10; 26(7):549-564. PMID: 32538259.
      View in: PubMed
    8. De Dios R, Nguyen L, Ghosh S, McKenna S, Wright CJ. CpG-ODN-mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NF?B inhibitory protein I?Bß to drive IL1a and IL1ß expression. Immunology. 2020 05; 160(1):64-77. PMID: 32064589.
      View in: PubMed
    9. Butler B, Wright CJ. Does hydrocortisone reduce death and BPD in preterm infants who remain intubated beyond a week of life? Acta Paediatr. 2020 07; 109(7):1495-1496. PMID: 32167184.
      View in: PubMed
    10. Sherlock LG, Wright CJ, Kinsella JP, Delaney C. Inhaled nitric oxide use in neonates: Balancing what is evidence-based and what is physiologically sound. Nitric Oxide. 2020 02 01; 95:12-16. PMID: 31866361.
      View in: PubMed
    11. Sandoval J, Orlicky DJ, Allawzi A, Butler B, Ju C, Phan CT, Toston R, De Dios R, Nguyen L, McKenna S, Nozik-Grayck E, Wright CJ. Toxic Acetaminophen Exposure Induces Distal Lung ER Stress, Proinflammatory Signaling, and Emphysematous Changes in the Adult Murine Lung. Oxid Med Cell Longev. 2019; 2019:7595126. PMID: 31885815.
      View in: PubMed
    12. Bourque SL, Roberts RS, Wright CJ, Kirpalani H, Lemyre B, Millar D, Bamat NA. Nasal Intermittent Positive Pressure Ventilation Versus Nasal Continuous Positive Airway Pressure to Prevent Primary Noninvasive Ventilation Failure in Extremely Low Birthweight Infants. J Pediatr. 2020 01; 216:218-221.e1. PMID: 31604630.
      View in: PubMed
    13. Butler B, De Dios R, Nguyen L, McKenna S, Ghosh S, Wright CJ. Developmentally Regulated Innate Immune NF?B Signaling Mediates IL-1a Expression in the Perinatal Murine Lung. Front Immunol. 2019; 10:1555. PMID: 31354715.
      View in: PubMed
    14. Nguyen L, Castro O, De Dios R, Sandoval J, McKenna S, Wright CJ. Sex-differences in LPS-induced neonatal lung injury. Sci Rep. 2019 06 11; 9(1):8514. PMID: 31186497.
      View in: PubMed
    15. Marrs LK, Zenge JP, Barry JS, Wright CJ. Achieving Procedural Competency during Neonatal Fellowship Training: Can Trainees Teach Us How to Teach? Neonatology. 2019; 116(1):17-19. PMID: 30889581.
      View in: PubMed
    16. Nguyen L, Sandoval J, De Dios R, Yihdego E, Zarate M, Castro O, McKenna S, Wright CJ. The hepatic innate immune response is lobe-specific in a murine model endotoxemia. Innate Immun. 2019 02; 25(2):144-154. PMID: 30774009.
      View in: PubMed
    17. McKenna S, Burey T, Sandoval J, Nguyen L, Castro O, Gudipati S, Gonzalez J, El Kasmi KC, Wright CJ. Immunotolerant p50/NF?B Signaling and Attenuated Hepatic IFNß Expression Increases Neonatal Sensitivity to Endotoxemia. Front Immunol. 2018; 9:2210. PMID: 30319651.
      View in: PubMed
    18. Hwang SS, Burris HH, Collins JW, Kirpalani H, Wright CJ. Moving beyond race and ethnicity to understand the effect of inhaled nitric oxide on bronchopulmonary dysplasia prevention. J Pediatr. 2018 10; 201:298-300. PMID: 30029858.
      View in: PubMed
    19. El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ. Macrophage-derived IL-1ß/NF-?B signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018 04 11; 9(1):1393. PMID: 29643332.
      View in: PubMed
    20. Sherlock LG, Trumpie A, Hernandez-Lagunas L, McKenna S, Fisher S, Bowler R, Wright CJ, Delaney C, Nozik-Grayck E. Redistribution of Extracellular Superoxide Dismutase Causes Neonatal Pulmonary Vascular Remodeling and PH but Protects Against Experimental Bronchopulmonary Dysplasia. Antioxidants (Basel). 2018 Mar 14; 7(3). PMID: 29538340.
      View in: PubMed
    21. Wright CJ, Sherlock LG, Sahni R, Polin RA. Preventing Continuous Positive Airway Pressure Failure: Evidence-Based and Physiologically Sound Practices from Delivery Room to the Neonatal Intensive Care Unit. Clin Perinatol. 2018 06; 45(2):257-271. PMID: 29747887.
      View in: PubMed
    22. Dietz RM, Wright CJ. Oxidative stress diseases unique to the perinatal period: A window into the developing innate immune response. Am J Reprod Immunol. 2018 05; 79(5):e12787. PMID: 29194835.
      View in: PubMed
    23. Rozance PJ, Wright CJ. Preparing for the first breath: in the developing lung, maternal overnutrition takes centre stage. J Physiol. 2017 11 01; 595(21):6595-6596. PMID: 28925540.
      View in: PubMed
    24. McKenna S, Butler B, Jatana L, Ghosh S, Wright CJ. Inhibition of I?Bß/NF?B signaling prevents LPS-induced IL1ß expression without increasing apoptosis in the developing mouse lung. Pediatr Res. 2017 Dec; 82(6):1064-1072. PMID: 28753596.
      View in: PubMed
    25. Sherlock LG, Wright CJ. Preventing extubation failure in preterm infants: nasal CPAP remains the standard of care. Acta Paediatr. 2017 08; 106(8):1364. PMID: 28370320.
      View in: PubMed
    26. Wright CJ, Norman M, Kirpalani H, Johansson S. EBNEO commentaries in Acta Paediatrica: a new collaboration to advance evidence-based neonatology. Acta Paediatr. 2017 Mar; 106(3):358. PMID: 28186374.
      View in: PubMed
    27. Wright CJ, Polin RA. Noninvasive Support: Does It Really Decrease Bronchopulmonary Dysplasia? Clin Perinatol. 2016 12; 43(4):783-798. PMID: 27837759.
      View in: PubMed
    28. Wright CJ, Kirpalani H. When should we start continuous positive airway pressure in the delivery room and how high should we go? Acta Paediatr. 2016 Aug; 105(8):868-70. PMID: 27383516.
      View in: PubMed
    29. McKenna S, Eckman M, Parker A, Bok R, Hurt KJ, Wright CJ. Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NF?B-Dependent Mechanism. J Innate Immun. 2016; 8(4):386-99. PMID: 27160391.
      View in: PubMed
    30. Wright CJ, Polin RA, Kirpalani H. Continuous Positive Airway Pressure to Prevent Neonatal Lung Injury: How Did We Get Here, and How Do We Improve? J Pediatr. 2016 06; 173:17-24.e2. PMID: 27025910.
      View in: PubMed
    31. McKenna S, Gossling M, Bugarini A, Hill E, Anderson AL, Rancourt RC, Balasubramaniyan N, El Kasmi KC, Wright CJ. Endotoxemia Induces I?Bß/NF-?B-Dependent Endothelin-1 Expression in Hepatic Macrophages. J Immunol. 2015 Oct 15; 195(8):3866-79. PMID: 26342031.
      View in: PubMed
    32. McKenna S, Wright CJ. Inhibiting I?Bß-NF?B signaling attenuates the expression of select pro-inflammatory genes. J Cell Sci. 2015 Jun 01; 128(11):2143-55. PMID: 25908863.
      View in: PubMed
    33. Wright CJ, Permar SR. Preventing postnatal cytomegalovirus infection in the preterm infant: should it be done, can it be done, and at what cost? J Pediatr. 2015 Apr; 166(4):795-8. PMID: 25662832.
      View in: PubMed
    34. McKenna S, Michaelis KA, Agboke F, Liu T, Han K, Yang G, Dennery PA, Wright CJ. Sustained hyperoxia-induced NF-?B activation improves survival and preserves lung development in neonatal mice. . 2014 Jun 15; 306(12):L1078-89. PMID: 24748603.
      View in: PubMed
    35. Michaelis KA, Agboke F, Liu T, Han K, Muthu M, Galambos C, Yang G, Dennery PA, Wright CJ. I?Bß-mediated NF-?B activation confers protection against hyperoxic lung injury. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):429-38. PMID: 24066808.
      View in: PubMed
    36. Stewart MS, Dietz RM, Landman MP, Moulton SL, Wright CJ. Abdominal radiograph with intravesical air and possible small bowel atresia. J Pediatr. 2014 May; 164(5):1238-1238.e1. PMID: 24472230.
      View in: PubMed
    37. Wright CJ, Saugstad OD. OHRP and SUPPORT: lessons in balancing safety and improving the way we care for patients. J Pediatr. 2013 Nov; 163(5):1495-7. PMID: 24050739.
      View in: PubMed
    38. Benjamin J, Wright CJ. Thin catheter surfactant administration during spontaneous breathing in very low birth weight infants is associated with reduced need for mechanical ventilation. J Pediatr. 2013 Sep; 163(3):923-4. PMID: 23973239.
      View in: PubMed
    39. Tang JR, Michaelis KA, Nozik-Grayck E, Seedorf GJ, Hartman-Filson M, Abman SH, Wright CJ. The NF-?B inhibitory proteins I?Ba and I?Bß mediate disparate responses to inflammation in fetal pulmonary endothelial cells. J Immunol. 2013 Mar 15; 190(6):2913-23. PMID: 23418625.
      View in: PubMed
    40. Wright CJ. 50 Years ago in The Journal of Pediatrics: Some aspects of respiratory problems in the newborn: Cook CD. J Pediatric 1962;61:105-10. J Pediatr. 2012 Jul; 161(1):25. PMID: 22726322.
      View in: PubMed
    41. Wright CJ, Agboke F, Muthu M, Michaelis KA, Mundy MA, La P, Yang G, Dennery PA. Nuclear factor-?B (NF-?B) inhibitory protein I?Bß determines apoptotic cell death following exposure to oxidative stress. J Biol Chem. 2012 Feb 24; 287(9):6230-9. PMID: 22223647.
      View in: PubMed
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