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Julie Anne Siegenthaler

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-3123

    Collapse Research 
    Collapse research activities and funding
    R01NS131823     (SIEGENTHALER, JULIE)Jun 1, 2024 - May 31, 2029
    NIH
    CNS Fibroblast Formation and Function
    Role: Principal Investigator
    R03NS127154     (SIEGENTHALER, JULIE)Mar 1, 2022 - Feb 29, 2024
    NIH
    Formation and Function of the Meninges
    Role: Principal Investigator
    R03NS104566     (SIEGENTHALER, JULIE)Sep 1, 2018 - Aug 31, 2020
    NIH
    Foxc1 control of meninges formation and function
    Role: Principal Investigator
    R01NS098273     (SIEGENTHALER, JULIE)Jun 1, 2016 - Mar 31, 2026
    NIH
    Development and function of the meninges arachnoid barrier
    Role: Principal Investigator
    R56NS098273     (SIEGENTHALER, JULIE)Jun 1, 2016 - May 31, 2022
    NIH
    Development and function the meninges arachnoid barrier
    Role: Principal Investigator
    R00NS070920     (SIEGENTHALER, JULIE)Sep 15, 2012 - Aug 31, 2015
    NIH
    Forebrain angiogenesis in Foxc1 mutant mice
    Role: Principal Investigator
    K99NS070920     (SIEGENTHALER, JULIE)Jun 1, 2010 - May 31, 2012
    NIH
    Forebrain angiogenesis in Foxc1 mutant mice
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. DeSisto J, Donson AM, Griesinger AM, Fu R, Riemondy K, Mulcahy Levy J, Siegenthaler JA, Foreman NK, Vibhakar R, Green AL. Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high-grade glioma. Neuro Oncol. 2024 03 04; 26(3):538-552. PMID: 37934854.
      View in: PubMed
    2. Jones HE, Robertson GL, Romero-Morales A, O'Rourke R, Siegenthaler JA, Gama V. Leptomeningeal Neural Organoid (LMNO) Fusions as Models to Study Meninges-Brain Signaling. Res Sq. 2023 Dec 14. PMID: 38168409.
      View in: PubMed
    3. Gerschenfeld G, Coulpier F, Gresset A, Pulh P, Job B, Topilko T, Siegenthaler J, Kastriti ME, Brunet I, Charnay P, Topilko P. Neural tube-associated boundary caps are a major source of mural cells in the skin. Elife. 2023 Dec 14; 12. PMID: 38095361.
      View in: PubMed
    4. Jones HE, Robertson GL, Romero-Morales A, O'Rourke R, Siegenthaler JA, Gama V. Leptomeningeal Neural Organoid (LMNO) Fusions as Models to Study Meninges-Brain Signaling. bioRxiv. 2023 Dec 02. PMID: 38077064.
      View in: PubMed
    5. Jones HE, Coelho-Santos V, Bonney SK, Abrams KA, Shih AY, Siegenthaler JA. Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature. Development. 2023 Oct 01; 150(19). PMID: 37756588.
      View in: PubMed
    6. Derk J, Como CN, Jones HE, Joyce LR, Kim S, Spencer BL, Bonney S, O'Rourke R, Pawlikowski B, Doran KS, Siegenthaler JA. Formation and function of the meningeal arachnoid barrier around the developing mouse brain. Dev Cell. 2023 04 24; 58(8):635-644.e4. PMID: 36996816.
      View in: PubMed
    7. Jones HE, Coelho-Santos V, Bonney SK, Abrams KA, Shih AY, Siegenthaler JA. Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature. bioRxiv. 2023 Mar 23. PMID: 36993587.
      View in: PubMed
    8. Como CN, Kim S, Siegenthaler J. Stuck on you: Meninges cellular crosstalk in development. Curr Opin Neurobiol. 2023 04; 79:102676. PMID: 36773497.
      View in: PubMed
    9. Como CN, Cervantes C, Pawlikowski B, Siegenthaler J. Retinoic acid signaling in mouse retina endothelial cells is required for early angiogenic growth. Differentiation. 2023 Mar-Apr; 130:16-27. PMID: 36528974.
      View in: PubMed
    10. Jones HE, Abrams KA, Siegenthaler JA. Techniques for visualizing fibroblast-vessel interactions in the developing and adult CNS. Neurophotonics. 2022 Apr; 9(2):021911. PMID: 35402637.
      View in: PubMed
    11. Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, Toland A, Calcuttawala K, Shin H, P?lovics R, Shin A, Wang EY, Luo J, Gate D, Schulz-Schaeffer WJ, Chu P, Siegenthaler JA, McNerney MW, Keller A, Wyss-Coray T. A human brain vascular atlas reveals diverse mediators of Alzheimer's risk. Nature. 2022 03; 603(7903):885-892. PMID: 35165441.
      View in: PubMed
    12. Dorrier CE, Jones HE, Pintaric L, Siegenthaler JA, Daneman R. Emerging roles for CNS fibroblasts in health, injury and disease. Nat Rev Neurosci. 2022 01; 23(1):23-34. PMID: 34671105.
      View in: PubMed
    13. Derk J, Jones HE, Como C, Pawlikowski B, Siegenthaler JA. Corrigendum: Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease. Front Cell Neurosci. 2021; 15:761506. PMID: 34690706.
      View in: PubMed
    14. Como CN, Jones HE, Siegenthaler JA. Not just a 'drain': venules sprout brain capillaries. Trends Neurosci. 2021 11; 44(11):849-851. PMID: 34452754.
      View in: PubMed
    15. Derk J, Jones HE, Como C, Pawlikowski B, Siegenthaler JA. Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease. Front Cell Neurosci. 2021; 15:703944. PMID: 34276313.
      View in: PubMed
    16. DeSisto J, O'Rourke R, Jones HE, Pawlikowski B, Malek AD, Bonney S, Guimiot F, Jones KL, Siegenthaler JA. Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function. Dev Cell. 2020 07 06; 54(1):43-59.e4. PMID: 32634398.
      View in: PubMed
    17. Bonney S, Seitz S, Ryan CA, Jones KL, Clarke P, Tyler KL, Siegenthaler JA. Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis. mBio. 2019 08 06; 10(4). PMID: 31387911.
      View in: PubMed
    18. Adane B, Ye H, Khan N, Pei S, Minhajuddin M, Stevens BM, Jones CL, D'Alessandro A, Reisz JA, Zaberezhnyy V, Gasparetto M, Ho TC, Kelly KK, Myers JR, Ashton JM, Siegenthaler J, Kume T, Campbell EL, Pollyea DA, Becker MW, Jordan CT. The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells. Cell Rep. 2019 04 02; 27(1):238-254.e6. PMID: 30943405.
      View in: PubMed
    19. Pawlikowski B, Wragge J, Siegenthaler JA. Retinoic acid signaling in vascular development. Genesis. 2019 07; 57(7-8):e23287. PMID: 30801891.
      View in: PubMed
    20. Bonney S, Dennison BJC, Wendlandt M, Siegenthaler JA. Retinoic Acid Regulates Endothelial ?-catenin Expression and Pericyte Numbers in the Developing Brain Vasculature. Front Cell Neurosci. 2018; 12:476. PMID: 30568578.
      View in: PubMed
    21. Mishra S, Kelly KK, Rumian NL, Siegenthaler JA. Retinoic Acid Is Required for Neural Stem and Progenitor Cell Proliferation in the Adult Hippocampus. Stem Cell Reports. 2018 06 05; 10(6):1705-1720. PMID: 29805108.
      View in: PubMed
    22. Cheng L, Ge M, Lan Z, Ma Z, Chi W, Kuang W, Sun K, Zhao X, Liu Y, Feng Y, Huang Y, Luo M, Li L, Zhang B, Hu X, Xu L, Liu X, Huo Y, Deng H, Yang J, Xi Q, Zhang Y, Siegenthaler JA, Chen L. Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan; 92(1):469-485. PMID: 28871336.
      View in: PubMed
    23. Bonney S, Siegenthaler JA. Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties. eNeuro. 2017 May-Jun; 4(3). PMID: 28560318.
      View in: PubMed
    24. Zhao X, Sun K, Lan Z, Song W, Cheng L, Chi W, Chen J, Huo Y, Xu L, Liu X, Deng H, Siegenthaler JA, Chen L. Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity. Sci Rep. 2017 04 11; 7:46344. PMID: 28397817.
      View in: PubMed
    25. Wilde JJ, Siegenthaler JA, Dent SY, Niswander LA. Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling. J Neurosci. 2017 03 08; 37(10):2565-2579. PMID: 28154153.
      View in: PubMed
    26. Mishra S, Choe Y, Pleasure SJ, Siegenthaler JA. Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges. Dev Biol. 2016 Dec 01; 420(1):148-165. PMID: 27671872.
      View in: PubMed
    27. Bonney S, Harrison-Uy S, Mishra S, MacPherson AM, Choe Y, Li D, Jaminet SC, Fruttiger M, Pleasure SJ, Siegenthaler JA. Diverse Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016 07 20; 36(29):7786-801. PMID: 27445154.
      View in: PubMed
    28. Kelly KK, MacPherson AM, Grewal H, Strnad F, Jones JW, Yu J, Pierzchalski K, Kane MA, Herson PS, Siegenthaler JA. Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke. BMC Neurosci. 2016 07 15; 17(1):49. PMID: 27422020.
      View in: PubMed
    29. Wang L, Siegenthaler JA, Dowell RD, Yi R. Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science. 2016 Feb 05; 351(6273):613-7. PMID: 26912704.
      View in: PubMed
    30. Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF. Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking aV?8-TGF? signaling in the brain. Development. 2014 Dec; 141(23):4489-99. PMID: 25406396.
      View in: PubMed
    31. Keeney JG, Davis JM, Siegenthaler J, Post MD, Nielsen BS, Hopkins WD, Sikela JM. DUF1220 protein domains drive proliferation in human neural stem cells and are associated with increased cortical volume in anthropoid primates. Brain Struct Funct. 2015 Sep; 220(5):3053-60. PMID: 24957859.
      View in: PubMed
    32. Siegenthaler JA, Sohet F, Daneman R. 'Sealing off the CNS': cellular and molecular regulation of blood-brain barriergenesis. Curr Opin Neurobiol. 2013 Dec; 23(6):1057-64. PMID: 23867075.
      View in: PubMed
    33. Siegenthaler JA, Choe Y, Patterson KP, Hsieh I, Li D, Jaminet SC, Daneman R, Kume T, Huang EJ, Pleasure SJ. Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open. 2013 Jul 15; 2(7):647-59. PMID: 23862012.
      View in: PubMed
    34. Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein JL, Pleasure SJ. CoupTFI interacts with retinoic acid signaling during cortical development. PLoS One. 2013; 8(3):e58219. PMID: 23472160.
      View in: PubMed
    35. Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM. Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Mol Pharm. 2013 Feb 04; 10(2):650-63. PMID: 23268600.
      View in: PubMed
    36. Choe Y, Siegenthaler JA, Pleasure SJ. A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation. Neuron. 2012 Feb 23; 73(4):698-712. PMID: 22365545.
      View in: PubMed
    37. Zarbalis K, Choe Y, Siegenthaler JA, Orosco LA, Pleasure SJ. Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice. Neural Dev. 2012 Jan 17; 7:2. PMID: 22248045.
      View in: PubMed
    38. Munji RN, Choe Y, Li G, Siegenthaler JA, Pleasure SJ. Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors. J Neurosci. 2011 Feb 02; 31(5):1676-87. PMID: 21289176.
      View in: PubMed
    39. Siegenthaler JA, Pleasure SJ. We have got you 'covered': how the meninges control brain development. Curr Opin Genet Dev. 2011 Jun; 21(3):249-55. PMID: 21251809.
      View in: PubMed
    40. Hecht JH, Siegenthaler JA, Patterson KP, Pleasure SJ. Primary cellular meningeal defects cause neocortical dysplasia and dyslamination. Ann Neurol. 2010 Oct; 68(4):454-64. PMID: 20976766.
      View in: PubMed
    41. Siegenthaler JA, Pleasure SJ. There's no place like home for a neural stem cell. Cell Stem Cell. 2010 Aug 06; 7(2):141-3. PMID: 20682440.
      View in: PubMed
    42. Siegenthaler JA, Ashique AM, Zarbalis K, Patterson KP, Hecht JH, Kane MA, Folias AE, Choe Y, May SR, Kume T, Napoli JL, Peterson AS, Pleasure SJ. Retinoic acid from the meninges regulates cortical neuron generation. Cell. 2009 Oct 30; 139(3):597-609. PMID: 19879845.
      View in: PubMed
    43. Siegenthaler JA, Tremper-Wells BA, Miller MW. Foxg1 haploinsufficiency reduces the population of cortical intermediate progenitor cells: effect of increased p21 expression. Cereb Cortex. 2008 Aug; 18(8):1865-75. PMID: 18065723.
      View in: PubMed
    44. Siegenthaler JA, Miller MW. Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways. Dev Biol. 2008 Jan 01; 313(1):35-46. PMID: 18005957.
      View in: PubMed
    45. Zarbalis K, Siegenthaler JA, Choe Y, May SR, Peterson AS, Pleasure SJ. Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14002-7. PMID: 17715063.
      View in: PubMed
    46. Siegenthaler JA, Miller MW. Ethanol disrupts cell cycle regulation in developing rat cortex interaction with transforming growth factor beta1. J Neurochem. 2005 Nov; 95(3):902-12. PMID: 16190877.
      View in: PubMed
    47. Siegenthaler JA, Miller MW. Transforming growth factor beta 1 promotes cell cycle exit through the cyclin-dependent kinase inhibitor p21 in the developing cerebral cortex. J Neurosci. 2005 Sep 21; 25(38):8627-36. PMID: 16177030.
      View in: PubMed
    48. Mooney SM, Siegenthaler JA, Miller MW. Ethanol induces heterotopias in organotypic cultures of rat cerebral cortex. Cereb Cortex. 2004 Oct; 14(10):1071-80. PMID: 15166098.
      View in: PubMed
    49. Siegenthaler JA, Miller MW. Transforming growth factor beta1 modulates cell migration in rat cortex: effects of ethanol. Cereb Cortex. 2004 Jul; 14(7):791-802. PMID: 15084492.
      View in: PubMed
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