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Julie Anne Siegenthaler

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
    Collapse research activities and funding
    K99NS070920     (SIEGENTHALER, JULIE)Jun 1, 2010 - May 31, 2012
    Forebrain angiogenesis in Foxc1 mutant mice
    Role: Principal Investigator

    R00NS070920     (SIEGENTHALER, JULIE)Sep 15, 2012 - Aug 31, 2015
    Forebrain angiogenesis in Foxc1 mutant mice
    Role: Principal Investigator

    R01NS098273     (SIEGENTHALER, JULIE)Jun 1, 2016 - May 31, 2021
    Retinoic Acid in Development of CNS Vasculature
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cheng L, Ge M, Lan Z, Ma Z, Chi W, Kuang W, Sun K, Zhao X, Liu Y, Feng Y, Huang Y, Luo M, Li L, Zhang B, Hu X, Xu L, Liu X, Huo Y, Deng H, Yang J, Xi Q, Zhang Y, Siegenthaler JA, Chen L. Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan; 92(1):469-485. PMID: 28871336.
      View in: PubMed
    2. Bonney S, Siegenthaler JA. Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties. eNeuro. 2017 May-Jun; 4(3). PMID: 28560318.
      View in: PubMed
    3. Zhao X, Sun K, Lan Z, Song W, Cheng L, Chi W, Chen J, Huo Y, Xu L, Liu X, Deng H, Siegenthaler JA, Chen L. Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity. Sci Rep. 2017 Apr 11; 7:46344. PMID: 28397817.
      View in: PubMed
    4. Wilde JJ, Siegenthaler JA, Dent SY, Niswander LA. Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling. J Neurosci. 2017 Mar 08; 37(10):2565-2579. PMID: 28154153.
      View in: PubMed
    5. Mishra S, Choe Y, Pleasure SJ, Siegenthaler JA. Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges. Dev Biol. 2016 Dec 01; 420(1):148-165. PMID: 27671872.
      View in: PubMed
    6. Bonney S, Harrison-Uy S, Mishra S, MacPherson AM, Choe Y, Li D, Jaminet SC, Fruttiger M, Pleasure SJ, Siegenthaler JA. Diverse Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016 07 20; 36(29):7786-801. PMID: 27445154; PMCID: PMC4951581 [Available on 01/20/17].
    7. Kelly KK, MacPherson AM, Grewal H, Strnad F, Jones JW, Yu J, Pierzchalski K, Kane MA, Herson PS, Siegenthaler JA. Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke. BMC Neurosci. 2016 07 15; 17(1):49. PMID: 27422020; PMCID: PMC4947279.
    8. Wang L, Siegenthaler JA, Dowell RD, Yi R. Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science. 2016 Feb 05; 351(6273):613-7. PMID: 26912704; PMCID: PMC4828140.
    9. Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF. Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking aVß8-TGFß signaling in the brain. Development. 2014 Dec; 141(23):4489-99. PMID: 25406396; PMCID: PMC4302931.
    10. Keeney JG, Davis JM, Siegenthaler J, Post MD, Nielsen BS, Hopkins WD, Sikela JM. DUF1220 protein domains drive proliferation in human neural stem cells and are associated with increased cortical volume in anthropoid primates. Brain Struct Funct. 2015 Sep; 220(5):3053-60. PMID: 24957859; PMCID: PMC4722867.
    11. Siegenthaler JA, Sohet F, Daneman R. 'Sealing off the CNS': cellular and molecular regulation of blood-brain barriergenesis. Curr Opin Neurobiol. 2013 Dec; 23(6):1057-64. PMID: 23867075; PMCID: PMC4061913.
    12. Siegenthaler JA, Choe Y, Patterson KP, Hsieh I, Li D, Jaminet SC, Daneman R, Kume T, Huang EJ, Pleasure SJ. Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open. 2013 Jul 15; 2(7):647-59. PMID: 23862012; PMCID: PMC3711032.
    13. Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein JL, Pleasure SJ. CoupTFI interacts with retinoic acid signaling during cortical development. PLoS One. 2013; 8(3):e58219. PMID: 23472160; PMCID: PMC3589372.
    14. Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM. Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Mol Pharm. 2013 Feb 04; 10(2):650-63. PMID: 23268600; PMCID: PMC4032224.
    15. Choe Y, Siegenthaler JA, Pleasure SJ. A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation. Neuron. 2012 Feb 23; 73(4):698-712. PMID: 22365545; PMCID: PMC3292762.
    16. Zarbalis K, Choe Y, Siegenthaler JA, Orosco LA, Pleasure SJ. Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice. Neural Dev. 2012 Jan 17; 7:2. PMID: 22248045; PMCID: PMC3287125.
    17. Munji RN, Choe Y, Li G, Siegenthaler JA, Pleasure SJ. Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors. J Neurosci. 2011 Feb 02; 31(5):1676-87. PMID: 21289176; PMCID: PMC3040956.
    18. Siegenthaler JA, Pleasure SJ. We have got you 'covered': how the meninges control brain development. Curr Opin Genet Dev. 2011 Jun; 21(3):249-55. PMID: 21251809; PMCID: PMC3105186.
    19. Hecht JH, Siegenthaler JA, Patterson KP, Pleasure SJ. Primary cellular meningeal defects cause neocortical dysplasia and dyslamination. Ann Neurol. 2010 Oct; 68(4):454-64. PMID: 20976766; PMCID: PMC2966036.
    20. Siegenthaler JA, Pleasure SJ. There's no place like home for a neural stem cell. Cell Stem Cell. 2010 Aug 06; 7(2):141-3. PMID: 20682440.
      View in: PubMed
    21. Siegenthaler JA, Ashique AM, Zarbalis K, Patterson KP, Hecht JH, Kane MA, Folias AE, Choe Y, May SR, Kume T, Napoli JL, Peterson AS, Pleasure SJ. Retinoic acid from the meninges regulates cortical neuron generation. Cell. 2009 Oct 30; 139(3):597-609. PMID: 19879845; PMCID: PMC2772834.
    22. Siegenthaler JA, Tremper-Wells BA, Miller MW. Foxg1 haploinsufficiency reduces the population of cortical intermediate progenitor cells: effect of increased p21 expression. Cereb Cortex. 2008 Aug; 18(8):1865-75. PMID: 18065723; PMCID: PMC2790389.
    23. Siegenthaler JA, Miller MW. Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways. Dev Biol. 2008 Jan 01; 313(1):35-46. PMID: 18005957; PMCID: PMC2278013.
    24. Zarbalis K, Siegenthaler JA, Choe Y, May SR, Peterson AS, Pleasure SJ. Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14002-7. PMID: 17715063; PMCID: PMC1955817.
    25. Siegenthaler JA, Miller MW. Ethanol disrupts cell cycle regulation in developing rat cortex interaction with transforming growth factor beta1. J Neurochem. 2005 Nov; 95(3):902-12. PMID: 16190877.
      View in: PubMed
    26. Siegenthaler JA, Miller MW. Transforming growth factor beta 1 promotes cell cycle exit through the cyclin-dependent kinase inhibitor p21 in the developing cerebral cortex. J Neurosci. 2005 Sep 21; 25(38):8627-36. PMID: 16177030.
      View in: PubMed
    27. Mooney SM, Siegenthaler JA, Miller MW. Ethanol induces heterotopias in organotypic cultures of rat cerebral cortex. Cereb Cortex. 2004 Oct; 14(10):1071-80. PMID: 15166098.
      View in: PubMed
    28. Siegenthaler JA, Miller MW. Transforming growth factor beta1 modulates cell migration in rat cortex: effects of ethanol. Cereb Cortex. 2004 Jul; 14(7):791-802. PMID: 15084492.
      View in: PubMed
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