Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Last Name

Contact Us
If you have any questions or feedback please contact us.

Kristofer S Fritz

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
    Collapse research activities and funding
    R01AA022146     (HIRSCHEY, MATTHEW D)Aug 5, 2013 - Jun 30, 2018
    Ethanol-induced Protein Acylation Regulates Metabolism
    Role: Co-Principal Investigator

    R01DK109964     (ROSS, DAVID)Apr 1, 2017 - Mar 31, 2022
    Regulation of insulin signaling and sensitivity by the xenobiotic metabolizing enzyme NQO1
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Tyagi A, Nguyen CU, Chong T, Michel CR, Fritz KS, Reisdorph N, Knaub L, Reusch JEB, Pugazhenthi S. SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. Sci Rep. 2018 Dec 03; 8(1):17547. PMID: 30510203.
      View in: PubMed
    2. Gomez JD, Ridgeway ME, Park MA, Fritz KS. Utilizing Ion Mobility to Identify Isobaric Post-Translational Modifications: Resolving Acrolein and Propionyl Lysine Adducts by TIMS Mass Spectrometry. Int J Ion Mobil Spectrom. 2018 Sep; 21(3):65-69. PMID: 30369833.
      View in: PubMed
    3. Gano LB, Liang LP, Ryan K, Michel CR, Gomez J, Vassilopoulos A, Reisdorph N, Fritz KS, Patel M. Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy. Free Radic Biol Med. 2018 Aug 01; 123:116-124. PMID: 29778462.
      View in: PubMed
    4. Reisdorph NA, Michel C, Fritz K, Reisdorph R. Application of Proteomics in Lung Research. Methods Mol Biol. 2018; 1809:237-262. PMID: 29987793.
      View in: PubMed
    5. Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS. Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. Alcohol Clin Exp Res. 2017 Oct; 41(10):1705-1714. PMID: 28804911.
      View in: PubMed
    6. Raghavendra AJ, Fritz K, Fu S, Brown JM, Podila R, Shannahan JH. Variations in biocorona formation related to defects in the structure of single walled carbon nanotubes and the hyperlipidemic disease state. Sci Rep. 2017 Aug 16; 7(1):8382. PMID: 28814800.
      View in: PubMed
    7. Harris PS, Gomez JD, Backos DS, Fritz KS. Characterizing Sirtuin 3 Deacetylase Affinity for Aldehyde Dehydrogenase 2. Chem Res Toxicol. 2017 03 20; 30(3):785-793. PMID: 28248093.
      View in: PubMed
    8. Galligan JJ, Kingsley PJ, Wauchope OR, Mitchener MM, Camarillo JM, Wepy JA, Harris PS, Fritz KS, Marnett LJ. Quantitative Analysis and Discovery of Lysine and Arginine Modifications. Anal Chem. 2017 01 17; 89(2):1299-1306. PMID: 27982582.
      View in: PubMed
    9. Heit C, Marshall S, Singh S, Yu X, Charkoftaki G, Zhao H, Orlicky DJ, Fritz KS, Thompson DC, Vasiliou V. Catalase deletion promotes prediabetic phenotype in mice. Free Radic Biol Med. 2017 02; 103:48-56. PMID: 27939935.
      View in: PubMed
    10. Heit C, Eriksson P, Thompson DC, Charkoftaki G, Fritz KS, Vasiliou V. Quantification of Neural Ethanol and Acetaldehyde Using Headspace GC-MS. Alcohol Clin Exp Res. 2016 09; 40(9):1825-31. PMID: 27501276.
      View in: PubMed
    11. Shannahan JH, Fritz KS, Raghavendra AJ, Podila R, Persaud I, Brown JM. From the Cover: Disease-Induced Disparities in Formation of the Nanoparticle-Biocorona and the Toxicological Consequences. Toxicol Sci. 2016 08; 152(2):406-16. PMID: 27255384.
      View in: PubMed
    12. Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR. Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice. Redox Biol. 2016 Apr; 7:68-77. PMID: 26654979; PMCID: PMC4683459.
    13. Coughlan C, Walker DI, Lohr KM, Richardson JR, Saba LM, Caudle WM, Fritz KS, Roede JR. Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice. Parkinsons Dis. 2015; 2015:812532. PMID: 26345149; PMCID: PMC4546751.
    14. Harris PS, Roy SR, Coughlan C, Orlicky DJ, Liang Y, Shearn CT, Roede JR, Fritz KS. Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney. Redox Biol. 2015 Dec; 6:33-40. PMID: 26177469; PMCID: PMC4511634.
    15. Blakeslee WW, Wysoczynski CL, Fritz KS, Nyborg JK, Churchill ME, McKinsey TA. Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism. Cell Signal. 2014 Dec; 26(12):2912-20. PMID: 25220405; PMCID: PMC4252807.
    16. Galligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DR. Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function. Free Radic Biol Med. 2014 Aug; 73:411-20. PMID: 24924946.
      View in: PubMed
    17. Poerschke RL, Fritz KS, Franklin CC. Methods to detect protein glutathionylation. Curr Protoc Toxicol. 2013 Sep 23; 57:Unit 6.17.. PMID: 24510510.
      View in: PubMed
    18. Fritz KS, Green MF, Petersen DR, Hirschey MD. Ethanol metabolism modifies hepatic protein acylation in mice. PLoS One. 2013; 8(9):e75868. PMID: 24073283; PMCID: PMC3779192.
    19. Backos DS, Fritz KS, McArthur DG, Kepa JK, Donson AM, Petersen DR, Foreman NK, Franklin CC, Reigan P. Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma. Neurochem Res. 2013 Sep; 38(9):1838-49. PMID: 23743623.
      View in: PubMed
    20. Smathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DR. Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver. J Lipid Res. 2013 May; 54(5):1335-45. PMID: 23359610; PMCID: PMC3622328.
    21. Fritz KS. Chemical acetylation and deacetylation. Methods Mol Biol. 2013; 1077:191-201. PMID: 24014408.
      View in: PubMed
    22. Galligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DR. Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease. J Toxicol. 2012; 2012:207594. PMID: 22829816; PMCID: PMC3399426.
    23. Fritz KS, Petersen DR. An overview of the chemistry and biology of reactive aldehydes. Free Radic Biol Med. 2013 Jun; 59:85-91. PMID: 22750507; PMCID: PMC3540155.
    24. Smathers RL, Fritz KS, Galligan JJ, Shearn CT, Reigan P, Marks MJ, Petersen DR. Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. PLoS One. 2012; 7(6):e38459. PMID: 22701647; PMCID: PMC3368874.
    25. Galligan JJ, Smathers RL, Fritz KS, Epperson LE, Hunter LE, Petersen DR. Protein carbonylation in a murine model for early alcoholic liver disease. Chem Res Toxicol. 2012 May 21; 25(5):1012-21. PMID: 22502949; PMCID: PMC3423195.
    26. Fritz KS, Kellersberger KA, Gomez JD, Petersen DR. 4-HNE adduct stability characterized by collision-induced dissociation and electron transfer dissociation mass spectrometry. Chem Res Toxicol. 2012 Apr 16; 25(4):965-70. PMID: 22404378; PMCID: PMC3328623.
    27. Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR. Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res. 2012 Mar 02; 11(3):1633-43. PMID: 22309199; PMCID: PMC3324946.
    28. Fritz KS, Petersen DR. Exploring the biology of lipid peroxidation-derived protein carbonylation. Chem Res Toxicol. 2011 Sep 19; 24(9):1411-9. PMID: 21812433; PMCID: PMC3178011.
    29. Vassilopoulos A, Fritz KS, Petersen DR, Gius D. The human sirtuin family: evolutionary divergences and functions. Hum Genomics. 2011 Jul; 5(5):485-96. PMID: 21807603; PMCID: PMC3230576.
    30. Shearn CT, Fritz KS, Thompson JA. Protein damage from electrophiles and oxidants in lungs of mice chronically exposed to the tumor promoter butylated hydroxytoluene. Chem Biol Interact. 2011 Jul 15; 192(3):278-86. PMID: 21536018.
      View in: PubMed
    31. Shearn CT, Fritz KS, Reigan P, Petersen DR. Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells. Biochemistry. 2011 May 17; 50(19):3984-96. PMID: 21438592.
      View in: PubMed
    32. Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR. 4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. Chem Res Toxicol. 2011 May 16; 24(5):651-62. PMID: 21449565; PMCID: PMC3113719.
    33. Shearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N, Petersen DR. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes. Mol Pharmacol. 2011 Jun; 79(6):941-52. PMID: 21415306; PMCID: PMC3102545.
    34. Galligan JJ, Fritz KS, Tipney H, Smathers RL, Roede JR, Shearn CT, Hunter LE, Petersen DR. Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion. J Proteome Res. 2011 Apr 01; 10(4):1837-47. PMID: 21319786; PMCID: PMC3501204.
    35. Backos DS, Fritz KS, Roede JR, Petersen DR, Franklin CC. Posttranslational modification and regulation of glutamate-cysteine ligase by the a,ß-unsaturated aldehyde 4-hydroxy-2-nonenal. Free Radic Biol Med. 2011 Jan 01; 50(1):14-26. PMID: 20970495; PMCID: PMC3014730.
    36. Shearn CT, Fritz KS, Meier BW, Kirichenko OV, Thompson JA. Carbonyl reductase inactivation may contribute to mouse lung tumor promotion by electrophilic metabolites of butylated hydroxytoluene: protein alkylation in vivo and in vitro. Chem Res Toxicol. 2008 Aug; 21(8):1631-41. PMID: 18597497.
      View in: PubMed
    37. Fritz KS, McKean AJ, Nelson JC, Wilcox RB. Analog-based free testosterone test results linked to total testosterone concentrations, not free testosterone concentrations. Clin Chem. 2008 Mar; 54(3):512-6. PMID: 18171714.
      View in: PubMed
    38. Fritz KS, Weiss RM, Nelson JC, Wilcox RB. Unequal concentrations of free T3 and free T4 after ultrafiltration. Clin Chem. 2007 Jul; 53(7):1384-5. PMID: 17582152.
      View in: PubMed
    39. Fritz KS, Wilcox RB, Nelson JC. Quantifying spurious free T4 results attributable to thyroxine-binding proteins in serum dialysates and ultrafiltrates. Clin Chem. 2007 May; 53(5):985-8. PMID: 17395710.
      View in: PubMed
    40. Fritz KS, Wilcox RB, Nelson JC. A direct free thyroxine (T4) immunoassay with the characteristics of a total T4 immunoassay. Clin Chem. 2007 May; 53(5):911-5. PMID: 17363415.
      View in: PubMed
    Fritz's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    Co-Authors Expand Description
    Similar People Expand Description
    Same Department Expand Description
    Physical Neighbors Expand Description

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)