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Magdalena M Gorska

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    R01HL122995     (GORSKA, MAGDALENA MARIA)Jan 1, 2015 - Nov 30, 2024
    NIH
    Asthma susceptibility due to environmental programming of innate immunity in utero
    Role: Principal Investigator

    R01AI143837     (GORSKA, MAGDALENA MARIA)Jul 20, 2020 - Jun 30, 2024
    NIH
    Maternal programming of the stem cell-basophil axis for asthma
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Verma M, Michalec L, Sripada A, McKay J, Sirohi K, Verma D, Sheth D, Martin R, Dyjack N, Seibold MA, Knapp JR, Tu TH, O'Connor BP, Gorska MM, Alam R. The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma. J Exp Med. 2021 Jul 05; 218(7). PMID: 34076685.
      View in: PubMed
    2. Barone R, Caruso Bavisotto C, Rappa F, Gargano ML, Macaluso F, Paladino L, Vitale AM, Alfano S, Campanella C, Gorska M, Di Felice V, Cappello F, Venturella G, Marino Gammazza A. JNK pathway and heat shock response mediate the survival of C26 colon carcinoma bearing mice fed with the mushroom Pleurotus eryngii var. eryngii without affecting tumor growth or cachexia. Food Funct. 2021 Apr 07; 12(7):3083-3095. PMID: 33720221.
      View in: PubMed
    3. Sripada A, Sirohi K, Michalec L, Guo L, McKay JT, Yadav S, Verma M, Good J, Rollins D, Gorska MM, Alam R. Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases. PLoS Biol. 2021 03; 19(3):e3001063. PMID: 33684096.
      View in: PubMed
    4. Qian Q, Chowdhury BP, Sun Z, Lenberg J, Alam R, Vivier E, Gorska MM. Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B. J Clin Invest. 2020 08 03; 130(8):4133-4151. PMID: 32407293.
      View in: PubMed
    5. Caruso Bavisotto C, Alberti G, Vitale AM, Paladino L, Campanella C, Rappa F, Gorska M, Conway de Macario E, Cappello F, Macario AJL, Marino Gammazza A. Hsp60 Post-translational Modifications: Functional and Pathological Consequences. Front Mol Biosci. 2020; 7:95. PMID: 32582761.
      View in: PubMed
    6. Liu S, Sirohi K, Verma M, McKay J, Michalec L, Sripada A, Danhorn T, Rollins D, Good J, Gorska MM, Martin RJ, Alam R. Optimal identification of human conventional and nonconventional (CRTH2-IL7Ra-) ILC2s using additional surface markers. J Allergy Clin Immunol. 2020 08; 146(2):390-405. PMID: 32032632.
      View in: PubMed
    7. Gorska MM. Mouse Models of Asthma. Methods Mol Biol. 2018; 1809:351-362. PMID: 29987800.
      View in: PubMed
    8. Verma M, Liu S, Michalec L, Sripada A, Gorska MM, Alam R. Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9+ and IL-13+ type 2 innate lymphoid cell subpopulations. J Allergy Clin Immunol. 2018 09; 142(3):793-803.e8. PMID: 29132961.
      View in: PubMed
    9. Lenberg J, Qian Q, Sun Z, Alam R, Gorska MM. Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1ß and IL-17A. J Allergy Clin Immunol. 2018 03; 141(3):1118-1122.e3. PMID: 28943469.
      View in: PubMed
    10. Liu S, Verma M, Michalec L, Liu W, Sripada A, Rollins D, Good J, Ito Y, Chu H, Gorska MM, Martin RJ, Alam R. Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin. J Allergy Clin Immunol. 2018 01; 141(1):257-268.e6. PMID: 28433687.
      View in: PubMed
    11. Gorska MM. Natural killer cells in asthma. Curr Opin Allergy Clin Immunol. 2017 Feb; 17(1):50-54. PMID: 27841766.
      View in: PubMed
    12. Marino Gammazza A, Campanella C, Barone R, Caruso Bavisotto C, Gorska M, Wozniak M, Carini F, Cappello F, D'Anneo A, Lauricella M, Zummo G, Conway de Macario E, Macario AJ, Di Felice V. Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence. Cancer Lett. 2017 01 28; 385:75-86. PMID: 27836734.
      View in: PubMed
    13. Liu W, Liu S, Verma M, Zafar I, Good JT, Rollins D, Groshong S, Gorska MM, Martin RJ, Alam R. Mechanism of TH2/TH17-predominant and neutrophilic TH2/TH17-low subtypes of asthma. J Allergy Clin Immunol. 2017 May; 139(5):1548-1558.e4. PMID: 27702673.
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    14. Kuban-Jankowska A, Sahu KK, Gorska M, Niedzialkowski P, Tuszynski JA, Ossowski T, Wozniak M. Aurintricarboxylic acid structure modifications lead to reduction of inhibitory properties against virulence factor YopH and higher cytotoxicity. World J Microbiol Biotechnol. 2016 Oct; 32(10):163. PMID: 27562597.
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    15. Gorska M, Wyszkowska RM, Kuban-Jankowska A, Wozniak M. Impact of Apparent Antagonism of Estrogen Receptor ß by Fulvestrant on Anticancer Activity of 2-Methoxyestradiol. Anticancer Res. 2016 May; 36(5):2217-26. PMID: 27127126.
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    16. Gorska M, Kuban-Jankowska A, Milczarek R, Wozniak M. Nitro-oxidative Stress Is Involved in Anticancer Activity of 17ß-Estradiol Derivative in Neuroblastoma Cells. Anticancer Res. 2016 Apr; 36(4):1693-8. PMID: 27069147.
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    17. Kuban-Jankowska A, Sahu KK, Gorska M, Tuszynski JA, Wozniak M. Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor. Oncotarget. 2016 Jan 19; 7(3):2229-38. PMID: 26735581.
      View in: PubMed
    18. Gorska M, Kuban-Jankowska A, Slawek J, Wozniak M. New Insight into 2-Methoxyestradiol- a Possible Physiological Link between Neurodegeneration and Cancer Cell Death. Curr Med Chem. 2016; 23(15):1513-27. PMID: 26980569.
      View in: PubMed
    19. Gorska M, Krzywiec PB, Kuban-Jankowska A, Zmijewski M, Wozniak M, Wierzbicka J, Piotrowska A, Siwicka K. Growth Inhibition of Osteosarcoma Cell Lines in 3D Cultures: Role of Nitrosative and Oxidative Stress. Anticancer Res. 2016 Jan; 36(1):221-9. PMID: 26722047.
      View in: PubMed
    20. Skora D, Gorska M. Heat shock proteins and their association with major pediatric malignancies. Front Biosci (Landmark Ed). 2016 Jan 01; 21:157-64. PMID: 26709766.
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    21. Wojtysiak D, Gorska M, Wojciechowska J. Muscle Fibre Characteristics and Physico-Chemical Parameters of m. semimembranosus from Pulawska, Polish Large White and Pietrain Pigs. Folia Biol (Krakow). 2016; 64(3):197-204. PMID: 29847080.
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    22. Kuban-Jankowska A, Gorska M, Jaremko L, Jaremko M, Tuszynski JA, Wozniak M. The physiological concentration of ferrous iron (II) alters the inhibitory effect of hydrogen peroxide on CD45, LAR and PTP1B phosphatases. Biometals. 2015 Dec; 28(6):975-86. PMID: 26407665.
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    23. Gorska M, Zmijewski MA, Kuban-Jankowska A, Wnuk M, Rzeszutek I, Wozniak M. Neuronal Nitric Oxide Synthase-Mediated Genotoxicity of 2-Methoxyestradiol in Hippocampal HT22 Cell Line. Mol Neurobiol. 2016 09; 53(7):5030-40. PMID: 26381428.
      View in: PubMed
    24. Kuban-Jankowska A, Sahu KK, Niedzialkowski P, Gorska M, Tuszynski JA, Ossowski T, Wozniak M. Redox process is crucial for inhibitory properties of aurintricarboxylic acid against activity of YopH: virulence factor of Yersinia pestis. Oncotarget. 2015 Jul 30; 6(21):18364-73. PMID: 26286963.
      View in: PubMed
    25. Gorska M, Kuban-Jankowska A, Zmijewski M, Marino Gammazza A, Cappello F, Wnuk M, Gorzynik M, Rzeszutek I, Daca A, Lewinska A, Wozniak M. DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol. Oncotarget. 2015 Jun 20; 6(17):15449-63. PMID: 25972363.
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    26. Kuban-Jankowska A, Gorska M, Tuszynski JA, Churchill CD, Winter P, Klobukowski M, Wozniak M. Inactivation of Protein Tyrosine Phosphatases by Peracids Correlates with the Hydrocarbon Chain Length. Cell Physiol Biochem. 2015; 36(3):1069-83. PMID: 26112900.
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    27. Zabul P, Wozniak M, Slominski AT, Preis K, Gorska M, Korozan M, Wieruszewski J, Zmijewski MA, Zabul E, Tuckey R, Kuban-Jankowska A, Mickiewicz W, Knap N. A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia. Int J Mol Sci. 2015 Jun 09; 16(6):13043-64. PMID: 26068234.
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    28. Christianson CA, Goplen NP, Zafar I, Irvin C, Good JT, Rollins DR, Gorentla B, Liu W, Gorska MM, Chu H, Martin RJ, Alam R. Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33. J Allergy Clin Immunol. 2015 Jul; 136(1):59-68.e14. PMID: 25617223.
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    29. Kuban-Jankowska A, Gorska M, Knap N, Cappello F, Wozniak M. Protein tyrosine phosphatases in pathological process. Front Biosci (Landmark Ed). 2015 Jan 01; 20:377-88. PMID: 25553456.
      View in: PubMed
    30. Gorska M, Kuban-Jankowska A, Zmijewski MA, Gorzynik M, Szkatula M, Wozniak M. Neuronal nitric oxide synthase induction in the antitumorigenic and neurotoxic effects of 2-methoxyestradiol. Molecules. 2014 Aug 28; 19(9):13267-81. PMID: 25170949.
      View in: PubMed
    31. Irvin C, Zafar I, Good J, Rollins D, Christianson C, Gorska MM, Martin RJ, Alam R. Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma. J Allergy Clin Immunol. 2014 Nov; 134(5):1175-1186.e7. PMID: 25042748.
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    32. Manners S, Alam R, Schwartz DA, Gorska MM. A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust. J Allergy Clin Immunol. 2014 Jul; 134(1):63-72. PMID: 24365139.
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    33. Gorska M, Marino Gammazza A, Zmijewski MA, Campanella C, Cappello F, Wasiewicz T, Kuban-Jankowska A, Daca A, Sielicka A, Popowska U, Knap N, Antoniewicz J, Wakabayashi T, Wozniak M. Geldanamycin-induced osteosarcoma cell death is associated with hyperacetylation and loss of mitochondrial pool of heat shock protein 60 (hsp60). PLoS One. 2013; 8(8):e71135. PMID: 24015183.
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    34. Kuban-Jankowska A, Tuszynski JA, Winter P, Gorska M, Knap N, Wozniak M. Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45. PLoS One. 2012; 7(12):e52495. PMID: 23300686.
      View in: PubMed
    35. Guo L, Chen C, Liang Q, Karim MZ, Gorska MM, Alam R. Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor. J Immunol. 2013 Jan 01; 190(1):159-67. PMID: 23225884.
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    36. Gorska MM, Alam R. Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia. Curr Allergy Asthma Rep. 2012 Oct; 12(5):396-401. PMID: 22729960.
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    37. Gorska M, Popowska U, Sielicka-Dudzin A, Kuban-Jankowska A, Sawczuk W, Knap N, Cicero G, Wozniak F. Geldanamycin and its derivatives as Hsp90 inhibitors. Front Biosci (Landmark Ed). 2012 Jun 01; 17:2269-77. PMID: 22652777.
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    38. Goplen N, Karim Z, Guo L, Zhuang Y, Huang H, Gorska MM, Gelfand E, Pagés G, Pouysségur J, Alam R. ERK1 is important for Th2 differentiation and development of experimental asthma. FASEB J. 2012 May; 26(5):1934-45. PMID: 22262639.
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    39. Gorska MM, Alam R. A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia. Blood. 2012 Feb 09; 119(6):1399-406. PMID: 22184408.
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    40. Rasulev B, Turabekova M, Gorska M, Kulig K, Bielejewska A, Lipkowski J, Leszczynski J. Use of quantitative structure-enantioselective retention relationship for the liquid chromatography chiral separation prediction of the series of pyrrolidin-2-one compounds. Chirality. 2012 Jan; 24(1):72-7. PMID: 22121071.
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    41. Kuban-Jankowska A, Knap N, Gorska M, Popowska U, Wozniak M. Protein tyrosine phosphatase CD45 as a molecular biosensor of hydrogen peroxide generation in cell culture media. Biochem Biophys Res Commun. 2011 Nov 18; 415(2):270-3. PMID: 22037457.
      View in: PubMed
    42. Liang Q, Guo L, Gogate S, Karim Z, Hanifi A, Leung DY, Gorska MM, Alam R. IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. J Immunol. 2010 Nov 15; 185(10):5704-13. PMID: 20926789.
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    43. Gorska MM, Goplen N, Liang Q, Alam R. Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma. J Immunol. 2010 Apr 15; 184(8):4488-96. PMID: 20220094.
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    44. Liu W, Tundwal K, Liang Q, Goplen N, Rozario S, Quayum N, Gorska M, Wenzel S, Balzar S, Alam R. Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function. Mol Cell Biol. 2010 Apr; 30(7):1783-99. PMID: 20123980.
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    45. Karim Z, Vepachedu R, Gorska M, Alam R. UNC119 inhibits dynamin and dynamin-dependent endocytic processes. Cell Signal. 2010 Jan; 22(1):128-37. PMID: 19781630.
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    46. Gorska MM, Liang Q, Karim Z, Alam R. Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation. J Immunol. 2009 Aug 01; 183(3):1675-84. PMID: 19592652.
      View in: PubMed
    47. Goplen N, Karim MZ, Liang Q, Gorska MM, Rozario S, Guo L, Alam R. Combined sensitization of mice to extracts of dust mite, ragweed, and Aspergillus species breaks through tolerance and establishes chronic features of asthma. J Allergy Clin Immunol. 2009 Apr; 123(4):925-32.e11. PMID: 19348928.
      View in: PubMed
    48. Liu W, Liang Q, Balzar S, Wenzel S, Gorska M, Alam R. Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways. J Allergy Clin Immunol. 2008 Apr; 121(4):893-902.e2. PMID: 18395552.
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    49. Goplen N, Gorska MM, Stafford SJ, Rozario S, Guo L, Liang Q, Alam R. A phosphosite screen identifies autocrine TGF-beta-driven activation of protein kinase R as a survival-limiting factor for eosinophils. J Immunol. 2008 Mar 15; 180(6):4256-64. PMID: 18322238.
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    50. Vepachedu R, Gorska MM, Singhania N, Cosgrove GP, Brown KK, Alam R. Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway. J Immunol. 2007 Jul 01; 179(1):682-90. PMID: 17579091.
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    51. Gorska MM, Liang Q, Stafford SJ, Goplen N, Dharajiya N, Guo L, Sur S, Gaestel M, Alam R. MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation. J Exp Med. 2007 Jul 09; 204(7):1637-52. PMID: 17576778.
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    52. Gorska-Ciebiada M, Ciebiada M, Gorska MM, Gorski P, Grzelewska-Rzymowska I. Intercellular adhesion molecule 1 and tumor necrosis factor alpha in asthma and persistent allergic rhinitis: relationship with disease severity. Ann Allergy Asthma Immunol. 2006 Jul; 97(1):66-72. PMID: 16892784.
      View in: PubMed
    53. Gorska MM, Cen O, Liang Q, Stafford SJ, Alam R. Differential regulation of interleukin 5-stimulated signaling pathways by dynamin. J Biol Chem. 2006 May 19; 281(20):14429-39. PMID: 16556602.
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    54. Gorska MM, Alam R. The signaling mechanism of eosinophil activation. Expert Rev Clin Immunol. 2005 Jul; 1(2):247-56. PMID: 20476938.
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    55. Gorska MM, Stafford SJ, Cen O, Sur S, Alam R. Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. J Exp Med. 2004 Feb 02; 199(3):369-79. PMID: 14757743.
      View in: PubMed
    56. Gorska MM, Alam R. Signaling molecules as therapeutic targets in allergic diseases. J Allergy Clin Immunol. 2003 Aug; 112(2):241-50; quiz 251. PMID: 12897726.
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    57. Alam R, Gorska M. 3. Lymphocytes. J Allergy Clin Immunol. 2003 Feb; 111(2 Suppl):S476-85. PMID: 12592294.
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    58. Cen O, Gorska MM, Stafford SJ, Sur S, Alam R. Identification of UNC119 as a novel activator of SRC-type tyrosine kinases. J Biol Chem. 2003 Mar 07; 278(10):8837-45. PMID: 12496276.
      View in: PubMed
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