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Fernando Holguin

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
    Other Positions
    TitleDivision Head
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-MED
    DivisionPUL GENERAL OPERATIONS


    Collapse Research 
    Collapse research activities and funding
    R33HL157069     (HOLGUIN, FERNANDO)May 1, 2022 - Apr 30, 2027
    NIH
    LIMA: Lipid anti-Inflammatory Mediators in Asthma to reduce airway hyperresponsiveness in obese asthmatics
    Role: Principal Investigator
    HL157069-01A1     (Fernando Holguin)Jan 1, 2022 - Jan 1, 2027
    nIH
    LIMA: Lipid Anti-Inflammatory Mediators in Asthma to reduce airway hyperresponsiveness in obese asthmatics
    Role Description: This is a cross over, randomized clinical trial of obese asthmatics, treated with CLX-10 (nitrated FA) to improve FEV1, asthma control and reduce bronchial hyperresponsiveness.
    Role: PI
    R01AI152504     (CHU, HONG W)Sep 16, 2020 - Aug 31, 2025
    NIH
    Parkin in mitochondrial dysfunction and airway inflammation of obese asthma
    Role: Co-Principal Investigator
    R01HL146542     (HOLGUIN, FERNANDO)Jul 1, 2019 - Jun 30, 2025
    NIH
    SANDIA: Supplementing L-citrulline to overweight late Asthma oNset phenotypes to increase airway L-arginine/ADMA ratio and Improve Asthma control
    Role: Principal Investigator
    R01HL132550     (FREEMAN, BRUCE ALAN)Aug 5, 2016 - Jun 30, 2021
    NIH
    Anti-Inflammatory Lipid Mediators in Asthma
    Role: Co-Principal Investigator
    R01HL129198     (WISNIVESKY, JUAN P)May 1, 2016 - Apr 30, 2021
    NIH
    Obesity and Asthma: Unveiling Metabolic and Behavioral Pathways
    Role: Co-Principal Investigator
    R24MD008046     (WALLACE, JOHN M.)Jan 1, 2013 - Nov 30, 2016
    NIH
    Healthy Learning, Healthy Living Healthy Lives
    Role: Co-Principal Investigator
    R01HL114536     (PITT, BRUCE ROBERT)Aug 1, 2012 - Jul 31, 2018
    NIH
    Validating GIS-based methods to address spatial uncertainty in clinical trials
    Role: Co-Principal Investigator
    U10HL098177     (WENZEL, SALLY E)Sep 30, 2009 - Jun 30, 2018
    NIH
    AsthmaNet: Phenotypic Influences on Asthma Treatments
    Role: Co-Principal Investigator
    PR203496     (Fernando Holguin)
    Department of Defense U.S. Army Medical Research and Development Command Congressionally Directed Medical Research Programs
    Study to improve dEployment related Asthma by using L-citrulline Supplementation (SEALS)
    Role Description: Study is a RCT of L-citrulline supplementation for military personnel diagnosed with deployment related asthma.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rockette-Wagner B, Wisnivesky JP, Holguin F, Ankam J, Arora A, Federmann E, Smith V, Federman AD, Conroy MB. The relationships between Physical activity and asthma control and Body Mass Index (BMI) in patients with asthma. J Asthma. 2024 03; 61(3):194-202. PMID: 37847059.
      View in: PubMed
    2. Foer D, Forno E, Holguin F, Cahill KN. Weight Loss Interventions for Adults With Obesity-Related Asthma. J Allergy Clin Immunol Pract. 2024 Apr; 12(4):840-847. PMID: 38159807.
      View in: PubMed
    3. Colon Hidalgo D, Ramos KJ, Harlan EA, Holguin F, Forno E, Weiner DJ, Griffith MF. Historic Use of Race-Based Spirometry Values Lowered Transplant Priority for Black Patients. Chest. 2024 Feb; 165(2):381-388. PMID: 37832783.
      View in: PubMed
    4. Perez-Garcia J, Pino-Yanes M, Plender EG, Everman JL, Eng C, Jackson ND, Moore CM, Beckman KB, Medina V, Sharma S, Winnica DE, Holguin F, Rodr?guez-Santana J, Villar J, Ziv E, Seibold MA, Burchard EG. Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells. Clin Epigenetics. 2023 10 03; 15(1):156. PMID: 37784136.
      View in: PubMed
    5. Hudler AC, D?az IRR, Sharma S, Holguin F. Gaps and Future Directions in Clinical Research on Obesity-Related Asthma. Pulm Ther. 2023 Sep; 9(3):309-327. PMID: 37330948.
      View in: PubMed
    6. Agrawal N, Lin JL, Ankam J, Holguin F, Wisnivesky JP, Federman A. Assessing the interrelationship between asthma and obesity self-management behaviors. J Behav Med. 2024 02; 47(1):62-70. PMID: 37278861.
      View in: PubMed
    7. Althoff MD, Peterson R, McGrath M, Jin Y, Grasemann H, Sharma S, Federman A, Wisnivesky JP, Holguin F. Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism. BMJ Open Respir Res. 2023 06; 10(1). PMID: 37270184.
      View in: PubMed
    8. Dimasuay KG, Berg B, Schaunaman N, Holguin F, Winnica D, Chu HW. High-fat diet and palmitic acid amplify airway type 2 inflammation. Front Allergy. 2023; 4:1193480. PMID: 37287831.
      View in: PubMed
    9. Heinrich VA, Uvalle C, Manni ML, Li K, Mullett SJ, Donepudi SR, Clader J, Fitch A, Ellgass M, Cechova V, Qin S, Holguin F, Freeman BA, Meth? BA, Morris A, Gelhaus SL. Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma. Front Microbiomes. 2023; 2. PMID: 37293566.
      View in: PubMed
    10. Sapkota G, Delgado E, VanLeeuwen D, Holguin FO, Flores N, Yao S. Preservation of Phenols, Antioxidant Activity, and Cyclic Adenosine Monophosphate in Jujube (Ziziphus jujuba Mill.) Fruits with Different Drying Methods. Plants (Basel). 2023 Apr 28; 12(9). PMID: 37176863.
      View in: PubMed
    11. Steiling K, Kathuria H, Echieh CP, Ost DE, Rivera MP, Begnaud A, Celed?n JC, Charlot M, Dietrick F, Duma N, Fong KM, Ford JG, Gould MK, Holguin F, P?rez-Stable EJ, Tanner NT, Thomson CC, Wiener RS, Wisnivesky J. Research Priorities for Interventions to Address Health Disparities in Lung Nodule Management: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2023 03 15; 207(6):e31-e46. PMID: 36920066.
      View in: PubMed
    12. Bush A, Holguin F, Porsbjerg C, Saglani S. Asthma: Closing in on the Biology of a Complex Life-course Disease. Am J Respir Crit Care Med. 2023 02 15; 207(4):375-376. PMID: 36598866.
      View in: PubMed
    13. Jaramillo AM, Harder AQ, Holguin F, Evans CM. Vagal Reflexes in Airway Hyperreactivity: Novel Pathways and a Note of Caution for Studies in Mice. Am J Respir Cell Mol Biol. 2023 02; 68(2):231-233. PMID: 36722775.
      View in: PubMed
    14. Luker HA, Salas KR, Esmaeili D, Holguin FO, Bendzus-Mendoza H, Hansen IA. Repellent efficacy of 20 essential oils on Aedes aegypti mosquitoes and Ixodes scapularis ticks in contact-repellency assays. Sci Rep. 2023 01 30; 13(1):1705. PMID: 36717735.
      View in: PubMed
    15. Althoff MD, Jimenez G, Peterson R, Jin Y, Grasemann H, Sharma S, Federman AD, Wisnivesky JP, Holguin F. Differences in L-arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apnea. Respir Res. 2022 Sep 05; 23(1):230. PMID: 36064404.
      View in: PubMed
    16. Hudler A, Holguin F, Sharma S. Type 2 or Non-Type 2 Asthma Exacerbations? That Is the Question. Am J Respir Crit Care Med. 2022 09 01; 206(5):521-522. PMID: 35584351.
      View in: PubMed
    17. Kozik AJ, Holguin F, Segal LN, Chatila TA, Dixon AE, Gern JE, Lozupone C, Lukacs N, Lumeng C, Molyneaux PL, Reisdorph N, Vujkovic-Cvijin I, Togias A, Huang YJ. Microbiome, Metabolism, and Immunoregulation of Asthma: An American Thoracic Society and National Institute of Allergy and Infectious Diseases Workshop Report. Am J Respir Cell Mol Biol. 2022 08; 67(2):155-163. PMID: 35914321.
      View in: PubMed
    18. Hudler A, Holguin F, Sharma S. Pathophysiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap. Immunol Allergy Clin North Am. 2022 08; 42(3):521-532. PMID: 35965042.
      View in: PubMed
    19. Forno E, Brandenburg DD, Castro-Rodriguez JA, Celis-Preciado CA, Holguin F, Licskai C, Lovinsky-Desir S, Pizzichini M, Teper A, Yang C, Celed?n JC. Asthma in the Americas: An Update: A Joint Perspective from the Brazilian Thoracic Society, Canadian Thoracic Society, Latin American Thoracic Society, and American Thoracic Society. Ann Am Thorac Soc. 2022 04; 19(4):525-535. PMID: 35030062.
      View in: PubMed
    20. Winnica DE, Monzon A, Ye S, Vladar EK, Saal M, Cooney R, Liu C, Sharma S, Holguin F. Airway epithelial Paraoxonase-2 in obese asthma. PLoS One. 2022; 17(3):e0261504. PMID: 35286330.
      View in: PubMed
    21. Hudler A, Holguin F, Althoff M, Fuhlbrigge A, Sharma S. Pathophysiology and clinical evaluation of the patient with unexplained persistent dyspnea. Expert Rev Respir Med. 2022 05; 16(5):511-518. PMID: 35034521.
      View in: PubMed
    22. Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Crotty Alexander L, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions. J Allergy Clin Immunol. 2022 02; 149(2):488-516.e9. PMID: 34848210.
      View in: PubMed
    23. Watchorn D, Holguin F. The use of biologics in personalized asthma care. Expert Rev Clin Immunol. 2021 12; 17(12):1301-1309. PMID: 34767743.
      View in: PubMed
    24. Windham S, Hirsch K, Peterson R, Douin D, Chauhan L, Heery L, Fling C, Vukovic N, Holguin F, Zimmer S, Erlandson K. The Predictive Potential of Elevated Serum Inflammatory Markers in Determining the Need for Intubation in CoVID-19 Patients. J Crit Care Med (Targu Mures). 2022 Jan; 8(1):14-22. PMID: 35274051.
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    25. Ortega VE, Daya M, Szefler SJ, Bleecker ER, Chinchilli VM, Phipatanakul W, Mauger D, Martinez FD, Herrera-Luis E, Pino-Yanes M, Hawkins GA, Ampleford EJ, Kunselman SJ, Cox C, Bacharier LB, Cabana MD, Cardet JC, Castro M, Denlinger LC, Eng C, Fitzpatrick AM, Holguin F, Hu D, Jackson DJ, Jarjour N, Kraft M, Krishnan JA, Lazarus SC, Lemanske RF, Lima JJ, Lugogo N, Mak A, Moore WC, Naureckas ET, Peters SP, Pongracic JA, Sajuthi SP, Seibold MA, Smith LJ, Solway J, Sorkness CA, Wenzel S, White SR, Burchard EG, Barnes K, Meyers DA, Israel E, Wechsler ME. Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma. Lancet Child Adolesc Health. 2021 12; 5(12):862-872. PMID: 34762840.
      View in: PubMed
    26. Charokopos A, Braman SS, Brown SAW, Mhango G, de-Torres JP, Zulueta JJ, Sharma S, Holguin F, Sigel KM, Powell CA, Federman AD, Wisnivesky JP. Lung Cancer Risk among Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap. Ann Am Thorac Soc. 2021 11; 18(11):1894-1900. PMID: 34019783.
      View in: PubMed
    27. Holguin F. Metabolic Risk Factors and the Development of World Trade Center Lung Disease. Am J Respir Crit Care Med. 2021 11 01; 204(9):1008-1010. PMID: 34550869.
      View in: PubMed
    28. Althoff MD, Ghincea A, Wood LG, Holguin F, Sharma S. Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD. J Allergy Clin Immunol Pract. 2021 11; 9(11):3877-3884. PMID: 34506967.
      View in: PubMed
    29. Manni ML, Heinrich VA, Buchan GJ, O'Brien JP, Uvalle C, Cechova V, Koudelka A, Ukani D, Rawas-Qalaji M, Oury TD, Hart R, Ellgass M, Mullett SJ, Fajt ML, Wenzel SE, Holguin F, Freeman BA, Wendell SG. Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma. Sci Rep. 2021 09 07; 11(1):17788. PMID: 34493738.
      View in: PubMed
    30. Thakur N, Lovinsky-Desir S, Appell D, Bime C, Castro L, Celed?n JC, Ferreira J, George M, Mageto Y, Mainous III AG, Pakhale S, Riekert KA, Roman J, Ruvalcaba E, Sharma S, Shete P, Wisnivesky JP, Holguin F. Enhancing Recruitment and Retention of Minority Populations for Clinical Research in Pulmonary, Critical Care, and Sleep Medicine: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2021 08 01; 204(3):e26-e50. PMID: 34347574.
      View in: PubMed
    31. Grasemann H, Holguin F. An association of the arginase 1 gene with preschool wheezing phenotypes. Pediatr Pulmonol. 2021 07; 56(7):1821-1822. PMID: 33823086.
      View in: PubMed
    32. Scott JA, Maarsingh H, Holguin F, Grasemann H. Arginine Therapy for Lung Diseases. Front Pharmacol. 2021; 12:627503. PMID: 33833679.
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    33. Israel E, Denlinger LC, Bacharier LB, LaVange LM, Moore WC, Peters MC, Georas SN, Wright RJ, Mauger DT, Noel P, Akuthota P, Bach J, Bleecker ER, Cardet JC, Carr TF, Castro M, Cinelli A, Comhair SAA, Covar RA, Alexander LC, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Hoffman EA, Holguin F, Jackson DJ, Jain S, Jarjour NN, Ji Y, Kenyon NJ, Kosorok MR, Kraft M, Krishnan JA, Kumar R, Liu AH, Liu MC, Ly NP, Marquis MA, Martinez FD, Moy JN, O'Neal WK, Ortega VE, Peden DB, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Tulchinsky AF, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A. PrecISE: Precision Medicine in Severe Asthma: An adaptive platform trial with biomarker ascertainment. J Allergy Clin Immunol. 2021 05; 147(5):1594-1601. PMID: 33667479.
      View in: PubMed
    34. Clougherty JE, Kinnee EJ, Cardet JC, Mauger D, Bacharier L, Beigelman A, Blake KV, Cabana MD, Castro M, Chmiel JF, Covar R, Fitzpatrick A, Gaffin JM, Gentile D, Israel E, Jackson DJ, Kraft M, Krishnan JA, Kumar HV, Lang JE, Lazarus SC, Lemanske RF, Lima J, Martinez FD, Morgan W, Moy J, Myers R, Naureckas ET, Ortega VE, Peters SP, Phipatanakul W, Pongracic JA, Ross K, Sheehan WJ, Smith LJ, Solway J, Sorkness CA, Wechsler ME, Wenzel S, White SR, Holguin F. Geography, generalisability, and susceptibility in clinical trials. Lancet Respir Med. 2021 04; 9(4):330-332. PMID: 33539731.
      View in: PubMed
    35. Morgan LE, Jaramillo AM, Shenoy SK, Raclawska D, Emezienna NA, Richardson VL, Hara N, Harder AQ, NeeDell JC, Hennessy CE, El-Batal HM, Magin CM, Grove Villalon DE, Duncan G, Hanes JS, Suk JS, Thornton DJ, Holguin F, Janssen WJ, Thelin WR, Evans CM. Disulfide disruption reverses mucus dysfunction in allergic airway disease. Nat Commun. 2021 01 11; 12(1):249. PMID: 33431872.
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    36. Pollevick ME, Xu KY, Mhango G, Federmann EG, Vedanthan R, Busse P, Holguin F, Federman AD, Wisnivesky JP. The Relationship Between Asthma and Cardiovascular Disease: An Examination of the Framingham Offspring Study. Chest. 2021 04; 159(4):1338-1345. PMID: 33316236.
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    37. Althoff MD, Holguin F, Yang F, Grunwald GK, Moss M, Vandivier RW, Ho PM, Kiser TH, Burnham EL. Noninvasive Ventilation Use in Critically Ill Patients with Acute Asthma Exacerbations. Am J Respir Crit Care Med. 2020 12 01; 202(11):1520-1530. PMID: 32663410.
      View in: PubMed
    38. Broadhurst R, Peterson R, Wisnivesky JP, Federman A, Zimmer SM, Sharma S, Wechsler M, Holguin F. Asthma in COVID-19 Hospitalizations: An Overestimated Risk Factor? Ann Am Thorac Soc. 2020 12; 17(12):1645-1648. PMID: 32864985.
      View in: PubMed
    39. Sharma S, Khurana S, Federman AD, Wisnivesky J, Holguin F. Asthma-Chronic Obstructive Pulmonary Disease Overlap. Immunol Allergy Clin North Am. 2020 11; 40(4):565-573. PMID: 33012320.
      View in: PubMed
    40. Ivanova A, Israel E, LaVange LM, Peters MC, Denlinger LC, Moore WC, Bacharier LB, Marquis MA, Gotman NM, Kosorok MR, Tomlinson C, Mauger DT, Georas SN, Wright RJ, Noel P, Rosner GL, Akuthota P, Billheimer D, Bleecker ER, Cardet JC, Castro M, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Holguin F, Jain S, Kenyon NJ, Krishnan JA, Kraft M, Kumar R, Liu MC, Ly NP, Moy JN, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Wechsler ME, Wenzel SE, White SR. The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations. J Biopharm Stat. 2020 11 01; 30(6):1026-1037. PMID: 32941098.
      View in: PubMed
    41. Kinnee EJ, Tripathy S, Schinasi L, Shmool JLC, Sheffield PE, Holguin F, Clougherty JE. Geocoding Error, Spatial Uncertainty, and Implications for Exposure Assessment and Environmental Epidemiology. Int J Environ Res Public Health. 2020 08 12; 17(16). PMID: 32806682.
      View in: PubMed
    42. Reihman AE, Holguin F, Sharma S. Management of Severe Asthma Beyond the Guidelines. Curr Allergy Asthma Rep. 2020 06 16; 20(9):47. PMID: 32548649.
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    43. Dimasuay KG, Schaunaman N, Martin RJ, Pavelka N, Kolakowski C, Gottlieb RA, Holguin F, Chu HW. Parkin, an E3 ubiquitin ligase, enhances airway mitochondrial DNA release and inflammation. Thorax. 2020 09; 75(9):717-724. PMID: 32499407.
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    44. Khurana S, Bush A, Holguin F. Management of severe asthma: summary of the European Respiratory Society/American Thoracic Society task force report. Breathe (Sheff). 2020 Jun; 16(2):200058. PMID: 33304407.
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    45. Grasemann H, Holguin F. Oxidative stress and obesity-related asthma. Paediatr Respir Rev. 2021 Mar; 37:18-21. PMID: 32660723.
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    46. Fitzpatrick AM, Bacharier LB, Jackson DJ, Szefler SJ, Beigelman A, Cabana M, Covar R, Guilbert T, Holguin F, Lemanske RF, Martinez FD, Morgan W, Phipatanakul W, Pongracic JA, Raissy HH, Zeiger RS, Mauger DT. Heterogeneity of Mild to Moderate Persistent Asthma in Children: Confirmation by Latent Class Analysis and Association with 1-Year Outcomes. J Allergy Clin Immunol Pract. 2020 09; 8(8):2617-2627.e4. PMID: 32156610.
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    47. Fitzpatrick AM, Chipps BE, Holguin F, Woodruff PG. T2-"Low" Asthma: Overview and Management Strategies. J Allergy Clin Immunol Pract. 2020 02; 8(2):452-463. PMID: 32037109.
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    48. Holguin F. Sex Hormones and Asthma. Am J Respir Crit Care Med. 2020 01 15; 201(2):127-128. PMID: 31661291.
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    49. Holguin F, Cardet JC, Chung KF, Diver S, Ferreira DS, Fitzpatrick A, Gaga M, Kellermeyer L, Khurana S, Knight S, McDonald VM, Morgan RL, Ortega VE, Rigau D, Subbarao P, Tonia T, Adcock IM, Bleecker ER, Brightling C, Boulet LP, Cabana M, Castro M, Chanez P, Custovic A, Djukanovic R, Frey U, Frankem?lle B, Gibson P, Hamerlijnck D, Jarjour N, Konno S, Shen H, Vitary C, Bush A. Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2020 01; 55(1). PMID: 31558662.
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    50. Althoff M, Holguin F. Contemporary management techniques of asthma in obese patients. Expert Rev Respir Med. 2020 03; 14(3):249-257. PMID: 31852311.
      View in: PubMed
    51. Holguin F, Grasemann H, Sharma S, Winnica D, Wasil K, Smith V, Cruse MH, Perez N, Coleman E, Scialla TJ, Que LG. L-Citrulline increases nitric oxide and improves control in obese asthmatics. JCI Insight. 2019 12 19; 4(24). PMID: 31714895.
      View in: PubMed
    52. Thalanayar Muthukrishnan P, Nouraie M, Parikh A, Holguin F. Zileuton use and phenotypic features in asthma. Pulm Pharmacol Ther. 2020 02; 60:101872. PMID: 31841698.
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    53. Wechsler ME, Szefler SJ, Ortega VE, Pongracic JA, Chinchilli V, Lima JJ, Krishnan JA, Kunselman SJ, Mauger D, Bleecker ER, Bacharier LB, Beigelman A, Benson M, Blake KV, Cabana MD, Cardet JC, Castro M, Chmiel JF, Covar R, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Grossman N, Holguin F, Jackson DJ, Kumar H, Kraft M, LaForce CF, Lang J, Lazarus SC, Lemanske RF, Long D, Lugogo N, Martinez F, Meyers DA, Moore WC, Moy J, Naureckas E, Olin JT, Peters SP, Phipatanakul W, Que L, Raissy H, Robison RG, Ross K, Sheehan W, Smith LJ, Solway J, Sorkness CA, Sullivan-Vedder L, Wenzel S, White S, Israel E. Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma. N Engl J Med. 2019 09 26; 381(13):1227-1239. PMID: 31553835.
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    54. Grossman NL, Ortega VE, King TS, Bleecker ER, Ampleford EA, Bacharier LB, Cabana MD, Cardet JC, Carr TF, Castro M, Denlinger LC, Denson JL, Fandino N, Fitzpatrick AM, Hawkins GA, Holguin F, Krishnan JA, Lazarus SC, Nyenhuis SM, Phipatanakul W, Ramratnam SK, Wenzel S, Peters SP, Meyers DA, Wechsler ME, Israel E. Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials. J Allergy Clin Immunol. 2019 12; 144(6):1524-1533. PMID: 31520679.
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    55. Cardet JC, Jiang X, Lu Q, Gerard N, McIntire K, Boushey HA, Castro M, Chinchilli VM, Codispoti CD, Dyer AM, Holguin F, Kraft M, Lazarus S, Lemanske RF, Lugogo N, Mauger D, Moore WC, Moy J, Ortega VE, Peters SP, Smith LJ, Solway J, Sorkness CA, Sumino K, Wechsler ME, Wenzel S, Israel E. Reply. J Allergy Clin Immunol. 2019 09; 144(3):873-874. PMID: 31300279.
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    56. Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, Cabana MD, Cardet JC, Castro M, Chmiel J, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Hastie A, Holguin F, Israel E, Jackson D, Kraft M, LaForce C, Lemanske RF, Martinez FD, Moore W, Morgan WJ, Moy JN, Myers R, Peters SP, Phipatanakul W, Pongracic JA, Que L, Ross K, Smith L, Szefler SJ, Wechsler ME, Sorkness CA. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. N Engl J Med. 2019 05 23; 380(21):2009-2019. PMID: 31112384.
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    57. Forno E, Zhang P, Nouraie M, Courcoulas A, Mitchell JE, Wolfe BM, Strain G, Khandelwal S, Holguin F. The impact of bariatric surgery on asthma control differs among obese individuals with reported prior or current asthma, with or without metabolic syndrome. PLoS One. 2019; 14(4):e0214730. PMID: 30964910.
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    58. Khalid F, Holguin F. Idiopathic Hypereosinophilic Syndrome in an Elderly Female: A Case Report. Am J Case Rep. 2019 Mar 23; 20:381-384. PMID: 30902963.
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    59. Laje K, Seger M, Dungan B, Cooke P, Polle J, Holguin FO. Phytoene Accumulation in the Novel Microalga Chlorococcum sp. Using the Pigment Synthesis Inhibitor Fluridone. Mar Drugs. 2019 Mar 22; 17(3). PMID: 30909380.
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    60. Cardet JC, Jiang X, Lu Q, Gerard N, McIntire K, Boushey HA, Castro M, Chinchilli VM, Codispoti CD, Dyer AM, Holguin F, Kraft M, Lazarus S, Lemanske RF, Lugogo N, Mauger D, Moore WC, Moy J, Ortega VE, Peters SP, Smith LJ, Solway J, Sorkness CA, Sumino K, Wechsler ME, Wenzel S, Israel E. Loss of bronchoprotection with ICS plus LABA treatment, ?-receptor dynamics, and the effect of alendronate. J Allergy Clin Immunol. 2019 08; 144(2):416-425.e7. PMID: 30872116.
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    66. Dixon AE, Holguin F. Diet and Metabolism in the Evolution of Asthma and Obesity. Clin Chest Med. 2019 03; 40(1):97-106. PMID: 30691720.
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    67. Gill SS, Willette S, Dungan B, Jarvis JM, Schaub T, VanLeeuwen DM, St Hilaire R, Holguin FO. Suboptimal Temperature Acclimation Affects Kennedy Pathway Gene Expression, Lipidome and Metabolite Profile of Nannochloropsis salina during PUFA Enriched TAG Synthesis. Mar Drugs. 2018 Nov 01; 16(11). PMID: 30388843.
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    68. Roman J, Viegi G, Schenker M, Ojeda VD, P?rez-Stable EJ, Nemery B, Annesi-Maesano I, Patel SR, La Grutta S, Holguin F, Moughrabieh A, Bime C, Lindberg A, Migliori GB, de Vries G, Ram?rez J, Aliberti S, Feldman C, Celed?n JC. Research Needs on Respiratory Health in Migrant and Refugee Populations. An Official American Thoracic Society and European Respiratory Society Workshop Report. Ann Am Thorac Soc. 2018 11; 15(11):1247-1255. PMID: 30382778.
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    69. Holguin F. Triple CFTR Modulator Therapy for Cystic Fibrosis. N Engl J Med. 2018 10 25; 379(17):1671-1672. PMID: 30334694.
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    71. Fitzpatrick AM, Bacharier LB, Guilbert TW, Jackson DJ, Szefler SJ, Beigelman A, Cabana MD, Covar R, Holguin F, Lemanske RF, Martinez FD, Morgan W, Phipatanakul W, Pongracic JA, Zeiger RS, Mauger DT. Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation. J Allergy Clin Immunol Pract. 2019 03; 7(3):915-924.e7. PMID: 30267890.
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    72. Holguin F. Biological Treatments for Eosinophilic Asthma Enter the Airways. Am J Respir Crit Care Med. 2018 09 01; 198(5):551-552. PMID: 29993268.
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    76. Khalid F, Holguin F. A review of obesity and asthma across the life span. J Asthma. 2018 12; 55(12):1286-1300. PMID: 29420086.
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    78. Dabass A, Talbott EO, Rager JR, Marsh GM, Venkat A, Holguin F, Sharma RK. Systemic inflammatory markers associated with cardiovascular disease and acute and chronic exposure to fine particulate matter air pollution (PM2.5) among US NHANES adults with metabolic syndrome. Environ Res. 2018 02; 161:485-491. PMID: 29223110.
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    81. Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2):545-554.e4. PMID: 28866107.
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    82. Raysoni AU, Stock TH, Sarnat JA, Chavez MC, Sarnat SE, Montoya T, Holguin F, Li WW. Evaluation of VOC concentrations in indoor and outdoor microenvironments at near-road schools. Environ Pollut. 2017 Dec; 231(Pt 1):681-693. PMID: 28850936.
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    83. Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. Am J Respir Crit Care Med. 2017 06 01; 195(11):1439-1448. PMID: 27967215.
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    84. Suratt BT, Ubags NDJ, Rastogi D, Tantisira KG, Marsland BJ, Petrache I, Allen JB, Bates JHT, Holguin F, McCormack MC, Michelakis ED, Black SM, Jain M, Mora AL, Natarajan V, Miller YI, Fessler MB, Birukov KG, Summer RS, Shore SA, Dixon AE. An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc. 2017 Jun; 14(6):1050-1059. PMID: 28570148.
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    85. Cardet JC, Louisias M, King TS, Castro M, Codispoti CD, Dunn R, Engle L, Giles BL, Holguin F, Lima JJ, Long D, Lugogo N, Nyenhuis S, Ortega VE, Ramratnam S, Wechsler ME, Israel E, Phipatanakul W. Income is an independent risk factor for worse asthma outcomes. J Allergy Clin Immunol. 2018 02; 141(2):754-760.e3. PMID: 28535964.
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    86. Celed?n JC, Burchard EG, Schraufnagel D, Castillo-Salgado C, Schenker M, Balmes J, Neptune E, Cummings KJ, Holguin F, Riekert KA, Wisnivesky JP, Garcia JGN, Roman J, Kittles R, Ortega VE, Redline S, Mathias R, Thomas A, Samet J, Ford JG. An American Thoracic Society/National Heart, Lung, and Blood Institute Workshop Report: Addressing Respiratory Health Equality in the United States. Ann Am Thorac Soc. 2017 May; 14(5):814-826. PMID: 28459618.
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    87. Dandamudi KPR, Muppaneni T, Sudasinghe N, Schaub T, Holguin FO, Lammers PJ, Deng S. Co-liquefaction of mixed culture microalgal strains under sub-critical water conditions. Bioresour Technol. 2017 Jul; 236:129-137. PMID: 28399416.
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    88. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 02 01; 195(3):302-313. PMID: 27556234.
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    90. Nyenhuis SM, Krishnan JA, Berry A, Calhoun WJ, Chinchilli VM, Engle L, Grossman N, Holguin F, Israel E, Kittles RA, Kraft M, Lazarus SC, Lehman EB, Mauger DT, Moy JN, Peters SP, Phipatanakul W, Smith LJ, Sumino K, Szefler SJ, Wechsler ME, Wenzel S, White SR, Ackerman SJ. Race is associated with differences in airway inflammation in patients with asthma. J Allergy Clin Immunol. 2017 Jul; 140(1):257-265.e11. PMID: 28069248.
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    94. Winnica D, Que LG, Baffi C, Grasemann H, Fiedler K, Yang Z, Etling E, Wasil K, Wenzel SE, Freeman B, Holguin F. l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells. Clin Exp Allergy. 2017 Feb; 47(2):190-199. PMID: 27562295.
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    95. Ye J, Nouraie M, Holguin F, Gillespie AI. The Ability of Patient-Symptom Questionnaires to Differentiate PVFMD From Asthma. J Voice. 2017 May; 31(3):382.e1-382.e8. PMID: 27697409.
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    97. Barton JH, Ireland A, Fitzpatrick M, Kessinger C, Camp D, Weinman R, McMahon D, Leader JK, Holguin F, Wenzel SE, Morris A, Gingo MR. Adiposity influences airway wall thickness and the asthma phenotype of HIV-associated obstructive lung disease: a cross-sectional study. BMC Pulm Med. 2016 Aug 04; 16(1):111. PMID: 27488495.
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    99. Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med. 2016 07; 4(7):574-584. PMID: 27283230.
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    101. Nankar AN, Dungan B, Paz N, Sudasinghe N, Schaub T, Holguin FO, Pratt RC. Quantitative and qualitative evaluation of kernel anthocyanins from southwestern United States blue corn. J Sci Food Agric. 2016 Oct; 96(13):4542-52. PMID: 26879128.
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    105. Dabass A, Talbott EO, Venkat A, Rager J, Marsh GM, Sharma RK, Holguin F. Association of exposure to particulate matter (PM2.5) air pollution and biomarkers of cardiovascular disease risk in adult NHANES participants (2001-2008). Int J Hyg Environ Health. 2016 May; 219(3):301-10. PMID: 26725170.
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    109. Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CD, Cabana M, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF, Ly N, Meade K, Morgan W, Moy J, Olin T, Peters SP, Phipatanakul W, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Szefler SJ, Teague WG, Thyne S, Martinez FD. Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial. JAMA. 2015 Nov 17; 314(19):2034-2044. PMID: 26575060.
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    112. Mirabelli MC, Golan R, Greenwald R, Raysoni AU, Holguin F, Kewada P, Winquist A, Flanders WD, Sarnat JA. Modification of Traffic-related Respiratory Response by Asthma Control in a Population of Car Commuters. Epidemiology. 2015 Jul; 26(4):546-55. PMID: 25901844.
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    115. Thalanayar PM, Holguin F. Rash, disseminated intravascular coagulation and legionella: Episode 10 and a rewind into the past. Respir Med Case Rep. 2015; 15:95-100. PMID: 26236615.
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    116. Wendell SG, Golin-Bisello F, Wenzel S, Sobol RW, Holguin F, Freeman BA. 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ?-3 fatty acids. J Biol Chem. 2015 Feb 27; 290(9):5868-80. PMID: 25586183.
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    117. Juergens MT, Deshpande RR, Lucker BF, Park JJ, Wang H, Gargouri M, Holguin FO, Disbrow B, Schaub T, Skepper JN, Kramer DM, Gang DR, Hicks LM, Shachar-Hill Y. The regulation of photosynthetic structure and function during nitrogen deprivation in Chlamydomonas reinhardtii. Plant Physiol. 2015 Feb; 167(2):558-73. PMID: 25489023.
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    118. Xie M, Mustovich AT, Jiang Y, Trudeau JB, Ray A, Ray P, Hu H, Holguin F, Freeman B, Wenzel SE. IL-27 and type 2 immunity in asthmatic patients: association with severity, CXCL9, and signal transducer and activator of transcription signaling. J Allergy Clin Immunol. 2015 Feb; 135(2):386-94. PMID: 25312760.
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    119. Thalanayar PM, Holguin F. Follicular bronchiolitis in primary ciliary dyskinesia. Australas Med J. 2014; 7(7):294-7. PMID: 25157269.
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    123. Holguin F. The atopic march: IgE is not the only road. Lancet Respir Med. 2014 Feb; 2(2):88-90. PMID: 24503261.
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    125. Goldberg HJ, Holguin F. Carbon monoxide in small doses--a good thing? Am J Respir Crit Care Med. 2013 Nov 15; 188(10):1187-8. PMID: 24236586.
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    126. Yonas MA, Marsland AL, Emeremni CA, Moore CG, Holguin F, Wenzel S. Depressive symptomatology, quality of life and disease control among individuals with well-characterized severe asthma. J Asthma. 2013 Oct; 50(8):884-90. PMID: 23725317.
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    127. Holguin F. Arginine and nitric oxide pathways in obesity-associated asthma. J Allergy (Cairo). 2013; 2013:714595. PMID: 23710196.
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    129. Shields KN, Cavallari JM, Hunt MJ, Lazo M, Molina M, Molina L, Holguin F. Traffic-related air pollution exposures and changes in heart rate variability in Mexico City: a panel study. Environ Health. 2013 Jan 18; 12:7. PMID: 23327098.
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    130. Zora JE, Sarnat SE, Raysoni AU, Johnson BA, Li WW, Greenwald R, Holguin F, Stock TH, Sarnat JA. Associations between urban air pollution and pediatric asthma control in El Paso, Texas. Sci Total Environ. 2013 Mar 15; 448:56-65. PMID: 23312496.
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    131. Holguin F, Comhair SA, Hazen SL, Powers RW, Khatri SS, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Chung KF, Erzurum SC, Wenzel SE. An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. Am J Respir Crit Care Med. 2013 Jan 15; 187(2):153-9. PMID: 23204252.
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    132. Tunno BJ, Shields KN, Lioy P, Chu N, Kadane JB, Parmanto B, Pramana G, Zora J, Davidson C, Holguin F, Clougherty JE. Understanding intra-neighborhood patterns in PM2.5 and PM10 using mobile monitoring in Braddock, PA. Environ Health. 2012 Oct 10; 11:76. PMID: 23051204.
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    133. Coleman JM, Naik C, Holguin F, Ray A, Ray P, Trudeau JB, Wenzel SE. Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset. Thorax. 2012 Dec; 67(12):1061-6. PMID: 23015684.
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    134. Holguin F. The metabolic syndrome as a risk factor for lung function decline. Am J Respir Crit Care Med. 2012 Feb 15; 185(4):352-3. PMID: 22336675.
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    135. Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP, Sorkness RL, Teague WG, Wenzel SE, Busse WW. Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med. 2012 Feb 15; 185(4):356-62. PMID: 22095547.
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    136. Sarnat SE, Raysoni AU, Li WW, Holguin F, Johnson BA, Flores Luevano S, Garcia JH, Sarnat JA. Air pollution and acute respiratory response in a panel of asthmatic children along the U.S.-Mexico border. Environ Health Perspect. 2012 Mar; 120(3):437-44. PMID: 21896396.
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    137. Raysoni AU, Sarnat JA, Sarnat SE, Garcia JH, Holguin F, Lu?vano SF, Li WW. Binational school-based monitoring of traffic-related air pollutants in El Paso, Texas (USA) and Ciudad Ju?rez, Chihuahua (M?xico). Environ Pollut. 2011 Oct; 159(10):2476-86. PMID: 21778001.
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    138. Holguin F, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Moore WC, Peters SP, Yonas M, Teague WG, Wenzel SE. Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol. 2011 Jun; 127(6):1486-93.e2. PMID: 21624618.
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    139. Aujla SJ, Ross KR, Chmiel JF, Holguin F. Airway molecular phenotypes in pediatric asthma. Curr Opin Allergy Clin Immunol. 2011 Apr; 11(2):122-6. PMID: 21358402.
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    140. Holguin F, Rojas M, Brown LA, Fitzpatrick AM. Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls. J Asthma. 2011 Apr; 48(3):217-23. PMID: 21332421.
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    141. Gamble C, Talbott E, Youk A, Holguin F, Pitt B, Silveira L, Bleecker E, Busse W, Calhoun W, Castro M, Chung KF, Erzurum S, Israel E, Wenzel S. Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program. J Allergy Clin Immunol. 2010 Dec; 126(6):1149-56.e1. PMID: 21051082.
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    142. Dixon AE, Holguin F, Sood A, Salome CM, Pratley RE, Beuther DA, Celed?n JC, Shore SA. An official American Thoracic Society Workshop report: obesity and asthma. Proc Am Thorac Soc. 2010 Sep; 7(5):325-35. PMID: 20844291.
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    143. Fitzpatrick AM, Higgins M, Holguin F, Brown LA, Teague WG. The molecular phenotype of severe asthma in children. J Allergy Clin Immunol. 2010 Apr; 125(4):851-857.e18. PMID: 20371397.
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    144. Ryan PH, Holguin F. Traffic pollution as a risk factor for developing asthma: Are the issues resolved? Am J Respir Crit Care Med. 2010 Mar 15; 181(6):530-1. PMID: 20235346.
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    145. Holguin F, Cribbs S, Fitzpatrick AM, Ingram RH, Jackson AC. A deep breath bronchoconstricts obese asthmatics. J Asthma. 2010 Feb; 47(1):55-60. PMID: 20100022.
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    146. Holguin F, Fitzpatrick A. Obesity, asthma, and oxidative stress. J Appl Physiol (1985). 2010 Mar; 108(3):754-9. PMID: 19926826.
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    147. Fitzpatrick AM, Brown LA, Holguin F, Teague WG. Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma. J Allergy Clin Immunol. 2009 Nov; 124(5):990-6.e1-9. PMID: 19895987.
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    148. Crocker D, Brown C, Moolenaar R, Moorman J, Bailey C, Mannino D, Holguin F. Racial and ethnic disparities in asthma medication usage and health-care utilization: data from the National Asthma Survey. Chest. 2009 Oct; 136(4):1063-1071. PMID: 19567492.
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    149. Hern?ndez-Cadena L, Holguin F, Barraza-Villarreal A, Del R?o-Navarro BE, Sienra-Monge JJ, Romieu I. Increased levels of outdoor air pollutants are associated with reduced bronchodilation in children with asthma. Chest. 2009 Dec; 136(6):1529-1536. PMID: 19318670.
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    150. Kelley CF, Checkley W, Mannino DM, Franco-Paredes C, Del Rio C, Holguin F. Trends in hospitalizations for AIDS-associated Pneumocystis jirovecii Pneumonia in the United States (1986 to 2005). Chest. 2009 Jul; 136(1):190-197. PMID: 19255292.
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    151. Fitzpatrick AM, Teague WG, Holguin F, Yeh M, Brown LA. Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress. J Allergy Clin Immunol. 2009 Jan; 123(1):146-152.e8. PMID: 19130935.
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    152. Van Sickle D, Wenck MA, Belflower A, Drociuk D, Ferdinands J, Holguin F, Svendsen E, Bretous L, Jankelevich S, Gibson JJ, Garbe P, Moolenaar RL. Acute health effects after exposure to chlorine gas released after a train derailment. Am J Emerg Med. 2009 Jan; 27(1):1-7. PMID: 19041527.
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    153. Holguin F, Ramadan B, Gal AA, Roman J. Prognostic factors for hospital mortality and ICU admission in patients with ANCA-related pulmonary vasculitis. Am J Med Sci. 2008 Oct; 336(4):321-6. PMID: 18854674.
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    154. Holguin F. Traffic, outdoor air pollution, and asthma. Immunol Allergy Clin North Am. 2008 Aug; 28(3):577-88, viii-ix. PMID: 18572108.
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    155. Barraza-Villarreal A, Sunyer J, Hernandez-Cadena L, Escamilla-Nu?ez MC, Sienra-Monge JJ, Ram?rez-Aguilar M, Cortez-Lugo M, Holguin F, Diaz-S?nchez D, Olin AC, Romieu I. Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren. Environ Health Perspect. 2008 Jun; 116(6):832-8. PMID: 18560490.
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    156. Fitzpatrick AM, Holguin F, Teague WG, Brown LA. Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma. J Allergy Clin Immunol. 2008 Jun; 121(6):1372-8, 1378.e1-3. PMID: 18417198.
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    157. Onufrak SJ, Abramson JL, Austin HD, Holguin F, McClellan WM, Vaccarino LV. Relation of adult-onset asthma to coronary heart disease and stroke. Am J Cardiol. 2008 May 01; 101(9):1247-52. PMID: 18435952.
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    158. Holguin F, Rojas M, Hart CM. The peroxisome proliferator activated receptor gamma (PPARgamma) ligand rosiglitazone modulates bronchoalveolar lavage levels of leptin, adiponectin, and inflammatory cytokines in lean and obese mice. Lung. 2007 Dec; 185(6):367-72. PMID: 17909895.
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    159. Holguin F. Traffic related exposures and lung function in adults. Thorax. 2007 Oct; 62(10):837-8. PMID: 17909186.
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    160. Holguin F, Flores S, Ross Z, Cortez M, Molina M, Molina L, Rincon C, Jerrett M, Berhane K, Granados A, Romieu I. Traffic-related exposures, airway function, inflammation, and respiratory symptoms in children. Am J Respir Crit Care Med. 2007 Dec 15; 176(12):1236-42. PMID: 17641154.
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    161. Boulet LP, Hamid Q, Bacon SL, Bergeron C, Boulet LP, Chen Y, Dixon AE, Ernst P, Hamid Q, Holguin F, Irvin CG, Kimoff RJ, Komakula S, Laprise C, Lavoie KL, Shore SA, Teodorescu M, Vohl MC. Symposium on obesity and asthma - November 2, 2006. Can Respir J. 2007 May-Jun; 14(4):201-8. PMID: 17551594.
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    162. Komakula S, Khatri S, Mermis J, Savill S, Haque S, Rojas M, Brown L, Teague GW, Holguin F. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Respir Res. 2007 Apr 16; 8:32. PMID: 17437645.
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    163. Sarnat JA, Holguin F. Asthma and air quality. Curr Opin Pulm Med. 2007 Jan; 13(1):63-6. PMID: 17133127.
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    164. Nurmagambetov T, Atherly A, Williams S, Holguin F, Mannino DM, Redd SC. What is the cost to employers of direct medical care for chronic obstructive pulmonary disease? COPD. 2006 Dec; 3(4):203-9. PMID: 17361501.
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    165. Romieu I, T?llez-Rojo MM, Lazo M, Manzano-Pati?o A, Cortez-Lugo M, Julien P, B?langer MC, Hernandez-Avila M, Holguin F. Omega-3 fatty acid prevents heart rate variability reductions associated with particulate matter. Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1534-40. PMID: 16210665.
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    166. Holguin F, Folch E, Redd SC, Mannino DM. Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001. Chest. 2005 Oct; 128(4):2005-11. PMID: 16236848.
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    167. Holguin F, T?llez-Rojo MM, Lazo M, Mannino D, Schwartz J, Hern?ndez M, Romieu I. Cardiac autonomic changes associated with fish oil vs soy oil supplementation in the elderly. Chest. 2005 Apr; 127(4):1102-7. PMID: 15821181.
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    168. Kelley CF, Mannino DM, Homa DM, Savage-Brown A, Holguin F. Asthma phenotypes, risk factors, and measures of severity in a national sample of US children. Pediatrics. 2005 Mar; 115(3):726-31. PMID: 15741378.
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    169. Holguin F, Mannino DM, Ant? J, Mott J, Ford ES, Teague WG, Redd SC, Romieu I. Country of birth as a risk factor for asthma among Mexican Americans. Am J Respir Crit Care Med. 2005 Jan 15; 171(2):103-8. PMID: 15516539.
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