Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Xianzhong Meng

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-SRG
Phone303/724-6303

    Collapse Research 
    Collapse research activities and funding
    I01BX005163     (MENG, XIANZHONG)Jan 1, 2021 - Dec 31, 2024
    NIH
    Downregulation of Inflamm-aging for Protection Against Organ Damage in Sepsis
    Role: Principal Investigator

    R01GM129641     (MENG, XIANZHONG)Sep 1, 2018 - Aug 31, 2021
    NIH
    Mechanisms of cardiac dysfunction in sepsis
    Role: Principal Investigator

    R01HL121776     (MENG, XIANZHONG)Jul 1, 2015 - Jun 30, 2024
    NIH
    Suppression of AVIC inflammosteogenesis for prevention of CAVD progression
    Role: Principal Investigator

    R01AG039545     (MENG, XIANZHONG)Sep 15, 2011 - May 31, 2017
    NIH
    Inflammatory response of aging heart to surgical myocardial ischemia
    Role: Principal Investigator

    R01HL106582     (MENG, XIANZHONG)Dec 15, 2010 - Nov 30, 2021
    NIH
    Role of inflammatory response in aortic valve lesions
    Role: Principal Investigator

    R01HL079051     (MENG, XIANZHONG)Jun 1, 2005 - Apr 30, 2011
    NIH
    TLR4 and cardiac inflammatory response to I/R
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Luo Z, The E, Zhang P, Zhai Y, Yao Q, Ao L, Zeng Q, Fullerton DA, Meng X. Monocytes augment inflammatory responses in human aortic valve interstitial cells via ß2-integrin/ICAM-1-mediated signaling. Inflamm Res. 2022 Jun; 71(5-6):681-694. PMID: 35411432.
      View in: PubMed
    2. Zhang P, The E, Luo Z, Zhai Y, Yao Q, Ao L, Fullerton DA, Xu D, Meng X. Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity. Mol Med. 2022 01 21; 28(1):5. PMID: 35062861.
      View in: PubMed
    3. Gergen AK, Jarrett MJ, Li A, Meng X, Pratap A, Fullerton DA, Weyant MJ. Toll-like Receptor 4 Mediates Reflux-Induced Inflammation in a Murine Reflux Model. Semin Thorac Cardiovasc Surg. 2021 Sep 15. PMID: 34534678.
      View in: PubMed
    4. Zhao P, Yao Q, Zhang PJ, The E, Zhai Y, Ao L, Jarrett MJ, Dinarello CA, Fullerton DA, Meng X. Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery-on-a-chip. Sci Adv. 2021 08; 7(34). PMID: 34417174.
      View in: PubMed
    5. Gergen AK, Jarrett MJ, Li A, White AM, Meng X, Fullerton DA, Weyant MJ. Secretory Phospholipase A2 Inhibition Attenuates Adhesive Properties of Esophageal Barrett's Cells. J Surg Res. 2021 03; 259:562-568. PMID: 33261858.
      View in: PubMed
    6. Jarrett MJ, Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DA. Wnt Signaling Mediates Pro-Fibrogenic Activity in Human Aortic Valve Interstitial Cells. Ann Thorac Surg. 2021 08; 112(2):519-525. PMID: 33189669.
      View in: PubMed
    7. Zhang P, The E, Nedumaran B, Ao L, Jarrett MJ, Xu D, Fullerton DA, Meng X. Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level. Int J Biol Sci. 2020; 16(15):3062-3074. PMID: 33061818.
      View in: PubMed
    8. Gergen AK, Kohtz PD, Halpern AL, Li A, Meng X, Reece TB, Fullerton DA, Weyant MJ. Activation of Toll-Like Receptor 2 Promotes Proliferation of Human Lung Adenocarcinoma Cells. Anticancer Res. 2020 Oct; 40(10):5361-5369. PMID: 32988855.
      View in: PubMed
    9. Halpern AL, Kohtz PD, White AM, Houk AK, Rehring JF, Hanson L, McCarter MD, Joshi M, Meng X, Fullerton DA, Weyant MJ. Secretory Phospholipase A2 IIa Mediates Expression of Growth Factor Receptors in Esophageal Adenocarcinoma. Dig Dis Sci. 2021 03; 66(3):784-795. PMID: 32277371.
      View in: PubMed
    10. Yao Q, The E, Ao L, Zhai Y, Osterholt MK, Fullerton DA, Meng X. TLR4 Stimulation Promotes Human AVIC Fibrogenic Activity through Upregulation of Neurotrophin 3 Production. Int J Mol Sci. 2020 Feb 14; 21(4). PMID: 32074942.
      View in: PubMed
    11. Song R, Zhai Y, Ao L, Fullerton DA, Meng X. MicroRNA-204 Deficiency in Human Aortic Valves Elevates Valvular Osteogenic Activity. Int J Mol Sci. 2019 Dec 20; 21(1). PMID: 31861929.
      View in: PubMed
    12. Jarrett MJ, Yao Q, Venardos N, Weyant MJ, Reece TB, Meng X, Fullerton DA. Simvastatin down-regulates osteogenic response in cultured human aortic valve interstitial cells. J Thorac Cardiovasc Surg. 2021 04; 161(4):e261-e271. PMID: 31924353.
      View in: PubMed
    13. Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Nix JC, Azam T, Zhang L, Zhao R, Kieft JS, The E, Meng X, Dinarello CA. Interleukin-37 monomer is the active form for reducing innate immunity. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5514-5522. PMID: 30819901.
      View in: PubMed
    14. Halpern AL, Kohtz PD, Rove JY, Ao L, Meng X, Fullerton DA, Weyant MJ. Inhibition of secretory phospholipase A2 IIa attenuates prostaglandin E2-induced invasiveness in lung adenocarcinoma. Mol Cell Biochem. 2019 Jun; 456(1-2):145-156. PMID: 30684134.
      View in: PubMed
    15. Lee DJ, Cavasin MA, Rocker AJ, Soranno DE, Meng X, Shandas R, Park D. An injectable sulfonated reversible thermal gel for therapeutic angiogenesis to protect cardiac function after a myocardial infarction. J Biol Eng. 2019; 13:6. PMID: 30675179.
      View in: PubMed
    16. Deng XS, Meng X, Li F, Venardos N, Fullerton D, Jaggers J. MMP-12-Induced Pro-osteogenic Responses in Human Aortic Valve Interstitial Cells. J Surg Res. 2019 03; 235:44-51. PMID: 30691826.
      View in: PubMed
    17. Kohtz PD, Halpern AL, Eldeiry MA, Hazel K, Kalatardi S, Ao L, Meng X, Reece TB, Fullerton DA, Weyant MJ. Toll-Like Receptor-4 Is a Mediator of Proliferation in Esophageal Adenocarcinoma. Ann Thorac Surg. 2019 01; 107(1):233-241. PMID: 30292843.
      View in: PubMed
    18. Yamanaka K, Eldeiry M, Aftab M, Ryan TJ, Mares J, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB. Synergistic Reduction of Apoptosis With Diazoxide and Erythropoietin in Spinal Cord Ischemic Injury. Ann Thorac Surg. 2018 12; 106(6):1751-1758. PMID: 30193997.
      View in: PubMed
    19. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 30100024.
      View in: PubMed
    20. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 32046115.
      View in: PubMed
    21. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 28362018.
      View in: PubMed
    22. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 28332126.
      View in: PubMed
    23. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 28546218.
      View in: PubMed
    24. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 28438736.
      View in: PubMed
    25. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33272595.
      View in: PubMed
    26. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 35493479.
      View in: PubMed
    27. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 35001242.
      View in: PubMed
    28. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33774002.
      View in: PubMed
    29. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33901456.
      View in: PubMed
    30. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18544357.
      View in: PubMed
    31. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19476795.
      View in: PubMed
    32. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22993297.
      View in: PubMed
    33. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22248682.
      View in: PubMed
    34. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 20478717.
      View in: PubMed
    35. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12225974.
      View in: PubMed
    36. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12121864.
      View in: PubMed
    37. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 23079010.
      View in: PubMed
    38. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15514106.
      View in: PubMed
    39. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 17689698.
      View in: PubMed
    40. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 23640488.
      View in: PubMed
    41. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22982459.
      View in: PubMed
    42. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 23026565.
      View in: PubMed
    43. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21396625.
      View in: PubMed
    44. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21658725.
      View in: PubMed
    45. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11981446.
      View in: PubMed
    46. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12022752.
      View in: PubMed
    47. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 23735716.
      View in: PubMed
    48. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 24746950.
      View in: PubMed
    49. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 24918749.
      View in: PubMed
    50. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25439778.
      View in: PubMed
    51. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25454921.
      View in: PubMed
    52. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25823011.
      View in: PubMed
    53. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25655994.
      View in: PubMed
    54. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25990696.
      View in: PubMed
    55. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 28137840.
      View in: PubMed
    56. Yamanaka K, Eldeiry M, Aftab M, Mares J, Ryan TJ, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB. Optimized induction of beta common receptor enhances the neuroprotective function of erythropoietin in spinal cord ischemic injury. J Thorac Cardiovasc Surg. 2018 06; 155(6):2505-2516. PMID: 29523405.
      View in: PubMed
    57. Song R, Fullerton DA, Ao L, Zhao KS, Meng X. An epigenetic regulatory loop controls pro-osteogenic activation by TGF-ß1 or bone morphogenetic protein 2 in human aortic valve interstitial cells. J Biol Chem. 2017 05 26; 292(21):8657-8666. PMID: 28377507.
      View in: PubMed
    58. Yao Q, Song R, Ao L, Cleveland JC, Fullerton DA, Meng X. Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis. Am J Physiol Cell Physiol. 2017 Jun 01; 312(6):C697-C706. PMID: 28356268.
      View in: PubMed
    59. Hui H, Zhai Y, Ao L, Cleveland JC, Liu H, Fullerton DA, Meng X. Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget. 2017 Feb 28; 8(9):15663-15676. PMID: 28152512.
      View in: PubMed
    60. Cheng H, Yao Q, Song R, Zhai Y, Wang W, Fullerton DA, Meng X. Lysophosphatidylcholine activates the Akt pathway to upregulate extracellular matrix protein production in human aortic valve cells. J Surg Res. 2017 06 01; 213:243-250. PMID: 28601321.
      View in: PubMed
    61. Li J, Zhai Y, Ao L, Hui H, Fullerton DA, Dinarello CA, Meng X. Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice. Cytokine. 2017 07; 95:55-63. PMID: 28237874.
      View in: PubMed
    62. Zhan Q, Song R, Li F, Ao L, Zeng Q, Xu D, Fullerton DA, Meng X. Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-?B pathway. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C407-C417. PMID: 28052863.
      View in: PubMed
    63. Ao L, Zhai Y, Jin C, Cleveland JC, Fullerton DA, Meng X. Attenuated recovery of contractile function in aging hearts following global ischemia/reperfusion: Role of extracellular HSP27 and TLR4. Mol Med. 2017 Jan; 23:863-872. PMID: 28079228.
      View in: PubMed
    64. Lee DJ, Fontaine A, Meng X, Park D. Biomimetic Nerve Guidance Conduit Containing Intraluminal Microchannels with Aligned Nanofibers Markedly Facilitates in Nerve Regeneration. ACS Biomater Sci Eng. 2016 Aug 08; 2(8):1403-1410. PMID: 33434994.
      View in: PubMed
    65. Li J, Ao L, Zhai Y, Cleveland JC, Fullerton DA, Meng X. Gender disparity in the role of TLR2 in post-ischemic myocardial inflammation and injury. Int J Clin Exp Med. 2015; 8(7):10537-47. PMID: 26379843.
      View in: PubMed
    66. Yao Q, Song R, Ao L, Zhan Q, Cleveland JC, Yu X, Fullerton DA, Meng X. Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway. Biochim Biophys Acta. 2015 Sep; 1852(9):1940-9. PMID: 26122822.
      View in: PubMed
    67. Foley LS, Fullerton DA, Bennett DT, Freeman KA, Mares J, Bell MT, Cleveland JC, Weyant MJ, Meng X, Puskas F, Reece TB. Spinal Cord Ischemia-Reperfusion Injury Induces Erythropoietin Receptor Expression. Ann Thorac Surg. 2015 Jul; 100(1):41-6; discussion 46. PMID: 25865765.
      View in: PubMed
    68. Zhan Q, Song R, Zeng Q, Yao Q, Ao L, Xu D, Fullerton DA, Meng X. Activation of TLR3 induces osteogenic responses in human aortic valve interstitial cells through the NF-?B and ERK1/2 pathways. Int J Biol Sci. 2015; 11(4):482-93. PMID: 25798067.
      View in: PubMed
    69. Song R, Fullerton DA, Ao L, Zheng D, Zhao KS, Meng X. BMP-2 and TGF-ß1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells. J Mol Med (Berl). 2015 Apr; 93(4):403-12. PMID: 25412776.
      View in: PubMed
    70. Deng XS, Meng X, Zeng Q, Fullerton D, Mitchell M, Jaggers J. Adult aortic valve interstitial cells have greater responses to toll-like receptor 4 stimulation. Ann Thorac Surg. 2015 Jan; 99(1):62-71. PMID: 25442996.
      View in: PubMed
    71. Wang D, Zeng Q, Song R, Ao L, Fullerton DA, Meng X. Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-?B pathway in BMP-2 expression. Biochim Biophys Acta. 2014 Nov; 1843(11):2744-53. PMID: 25101972.
      View in: PubMed
    72. Bennett DT, Deng XS, Yu JA, Bell MT, Mauchley DC, Meng X, Reece TB, Fullerton DA, Weyant MJ. Cancer stem cell phenotype is supported by secretory phospholipase A2 in human lung cancer cells. Ann Thorac Surg. 2014 Aug; 98(2):439-45; discussion 445-6. PMID: 24928671.
      View in: PubMed
    73. Song R, Ao L, Zhao KS, Zheng D, Venardos N, Fullerton DA, Meng X. Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway. Inflamm Res. 2014 Sep; 63(9):703-10. PMID: 24875140.
      View in: PubMed
    74. Zeng Q, Song R, Ao L, Xu D, Venardos N, Fullerton DA, Meng X. Augmented osteogenic responses in human aortic valve cells exposed to oxLDL and TLR4 agonist: a mechanistic role of Notch1 and NF-?B interaction. PLoS One. 2014; 9(5):e95400. PMID: 24810405.
      View in: PubMed
    75. Bell MT, Puskas F, Agoston VA, Cleveland JC, Freeman KA, Gamboni F, Herson PS, Meng X, Smith PD, Weyant MJ, Fullerton DA, Reece TB. Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury. Circulation. 2013 Sep 10; 128(11 Suppl 1):S152-6. PMID: 24030400.
      View in: PubMed
    76. Nadlonek NA, Lee JH, Weyant MJ, Meng X, Fullerton DA. ox-LDL induces PiT-1 expression in human aortic valve interstitial cells. J Surg Res. 2013 Sep; 184(1):6-9. PMID: 23849774.
      View in: PubMed
    77. Smith PD, Bell MT, Puskas F, Meng X, Cleveland JC, Weyant MJ, Fullerton DA, Reece TB. Preservation of motor function after spinal cord ischemia and reperfusion injury through microglial inhibition. Ann Thorac Surg. 2013 May; 95(5):1647-53. PMID: 23541432.
      View in: PubMed
    78. Yu JA, Li H, Meng X, Fullerton DA, Nemenoff RA, Mitchell JD, Weyant MJ. Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells. J Thorac Cardiovasc Surg. 2012 Dec; 144(6):1479-85. PMID: 23026567.
      View in: PubMed
    79. Zeng Q, Jin C, Ao L, Cleveland JC, Song R, Xu D, Fullerton DA, Meng X. Cross-talk between the Toll-like receptor 4 and Notch1 pathways augments the inflammatory response in the interstitial cells of stenotic human aortic valves. Circulation. 2012 Sep 11; 126(11 Suppl 1):S222-30. PMID: 22965987.
      View in: PubMed
    80. Bell MT, Puskas F, Smith PD, Agoston VA, Fullerton DA, Meng X, Weyant MJ, Reece TB. Attenuation of spinal cord ischemia-reperfusion injury by specific a-2a receptor activation with dexmedetomidine. J Vasc Surg. 2012 Nov; 56(5):1398-402. PMID: 22832266.
      View in: PubMed
    81. Eun JC, Moore EE, Mauchley DC, Johnson CA, Meng X, Banerjee A, Wohlauer MV, Zarini S, Gijón MA, Murphy RC. The 5-lipoxygenase pathway is required for acute lung injury following hemorrhagic shock. Shock. 2012 Jun; 37(6):599-604. PMID: 22392149.
      View in: PubMed
    82. Sadaria MR, Reppert AE, Yu JA, Meng X, Fullerton DA, Reece TB, Weyant MJ. Statin therapy attenuates growth and malignant potential of human esophageal adenocarcinoma cells. J Thorac Cardiovasc Surg. 2011 Nov; 142(5):1152-60. PMID: 22014341.
      View in: PubMed
    83. Smith PD, Puskas F, Meng X, Cho D, Cleveland JC, Weyant MJ, Watkins MT, Fullerton DA, Reece TB. Ischemic dose-response in the spinal cord: both immediate and delayed paraplegia. J Surg Res. 2012 May 15; 174(2):238-44. PMID: 21543089.
      View in: PubMed
    84. Su X, Ao L, Shi Y, Johnson TR, Fullerton DA, Meng X. Oxidized low density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via Toll-like receptors 2 and 4. J Biol Chem. 2011 Apr 08; 286(14):12213-20. PMID: 21325271.
      View in: PubMed
    85. Smith PD, Puskas F, Fullerton DA, Meng X, Cho D, Cleveland JC, Weyant MJ, Reece TB. Attenuation of spinal cord ischemia and reperfusion injury by erythropoietin. J Thorac Cardiovasc Surg. 2011 Jan; 141(1):256-60. PMID: 21168028.
      View in: PubMed
    86. Li J, Jin C, Cleveland JC, Ao L, Xu D, Fullerton DA, Meng X. Enhanced inflammatory responses to toll-like receptor 2/4 stimulation in type 1 diabetic coronary artery endothelial cells: the effect of insulin. Cardiovasc Diabetol. 2010 Dec 16; 9:90. PMID: 21162749.
      View in: PubMed
    87. Mauchley D, Meng X, Johnson T, Teitelbaum J, Babu A, Fullerton DA, Weyant MJ. Heat shock protein 27: induction by gastroduodenal reflux in vivo and augmentation of human esophageal mucosal cell growth in vitro. J Thorac Cardiovasc Surg. 2010 Apr; 139(4):1019-25. PMID: 20304146.
      View in: PubMed
    88. Mauchley D, Meng X, Johnson T, Fullerton DA, Weyant MJ. Modulation of growth in human esophageal adenocarcinoma cells by group IIa secretory phospholipase A(2). J Thorac Cardiovasc Surg. 2010 Mar; 139(3):591-9; discussion 599. PMID: 20176206.
      View in: PubMed
    89. Mauchley D, Meng X, Babu A, Gamboni-Robertson F, Yang X, Banerjee A, Fullerton DA, Weyant MJ. Gastroduodenal reflux induces group IIa secretory phospholipase A(2) expression and activity in murine esophagus. Dis Esophagus. 2010 Jul; 23(5):430-6. PMID: 20095996.
      View in: PubMed
    90. Babu A, Mauchley D, Meng X, Banerjee AM, Gamboni-Robertson F, Fullerton DA, Weyant MJ. The secretory phospholipase A2 gene is required for gastroesophageal reflux-related changes in murine esophagus. J Gastrointest Surg. 2009 Dec; 13(12):2212-8. PMID: 19672667.
      View in: PubMed
    91. Yang X, Meng X, Su X, Mauchley DC, Ao L, Cleveland JC, Fullerton DA. Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2. J Thorac Cardiovasc Surg. 2009 Oct; 138(4):1008-15. PMID: 19664780.
      View in: PubMed
    92. Ao L, Zou N, Cleveland JC, Fullerton DA, Meng X. Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H21-8. PMID: 19448144.
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    93. Song Y, Fullerton DA, Mauchley D, Su X, Ao L, Yang X, Cleveland JC, Meng X. Microfilaments facilitate TLR4-mediated ICAM-1 expression in human aortic valve interstitial cells. J Surg Res. 2011 Mar; 166(1):52-8. PMID: 19691982.
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    94. Yang X, Fullerton DA, Su X, Ao L, Cleveland JC, Meng X. Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2. J Am Coll Cardiol. 2009 Feb 10; 53(6):491-500. PMID: 19195606.
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    95. Babu AN, Meng X, Zou N, Yang X, Wang M, Song Y, Cleveland JC, Weyant M, Banerjee A, Fullerton DA. Lipopolysaccharide stimulation of human aortic valve interstitial cells activates inflammation and osteogenesis. Ann Thorac Surg. 2008 Jul; 86(1):71-6. PMID: 18573401.
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    96. Cha J, Wang Z, Ao L, Zou N, Dinarello CA, Banerjee A, Fullerton DA, Meng X. Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia. Ann Thorac Surg. 2008 May; 85(5):1678-85. PMID: 18442564.
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    97. Zou N, Ao L, Cleveland JC, Yang X, Su X, Cai GY, Banerjee A, Fullerton DA, Meng X. Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2008 Jun; 294(6):H2805-13. PMID: 18441202.
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    98. Meng X, Ao L, Song Y, Babu A, Yang X, Wang M, Weyant MJ, Dinarello CA, Cleveland JC, Fullerton DA. Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C29-35. PMID: 17942642.
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    99. Ao L, Song Y, Fullerton DA, Dinarello CA, Meng X. The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction: role of TNF-alpha in TLR4-mediated ICAM-1 expression. Cytokine. 2007 Jun; 38(3):124-9. PMID: 17683945.
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    100. Netea MG, Azam T, Lewis EC, Joosten LA, Wang M, Langenberg D, Meng X, Chan ED, Yoon DY, Ottenhoff T, Kim SH, Dinarello CA. Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism. PLoS Med. 2006 Aug; 3(8):e277. PMID: 16903774.
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    101. Singleton KD, Serkova N, Banerjee A, Meng X, Gamboni-Robertson F, Wischmeyer PE. Glutamine attenuates endotoxin-induced lung metabolic dysfunction: potential role of enhanced heat shock protein 70. Nutrition. 2005 Feb; 21(2):214-23. PMID: 15723751.
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    102. Raeburn CD, Calkins CM, Zimmerman MA, Song Y, Ao L, Banerjee A, Harken AH, Meng X. ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation. Am J Physiol Regul Integr Comp Physiol. 2002 Aug; 283(2):R477-86. PMID: 12121861.
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    103. Raeburn CD, Dinarello CA, Zimmerman MA, Calkins CM, Pomerantz BJ, McIntyre RC, Harken AH, Meng X. Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H650-7. PMID: 12124212.
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    104. Calkins CM, Barsness K, Bensard DD, Vasquez-Torres A, Raeburn CD, Meng X, McIntyre RC. Toll-like receptor-4 signaling mediates pulmonary neutrophil sequestration in response to gram-positive bacterial enterotoxin. J Surg Res. 2002 May 15; 104(2):124-30. PMID: 12020131.
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    105. Shames BD, Barton HH, Reznikov LL, Cairns CB, Banerjee A, Harken AH, Meng X. Ischemia alone is sufficient to induce TNF-alpha mRNA and peptide in the myocardium. Shock. 2002 Feb; 17(2):114-9. PMID: 11837786.
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