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Xianzhong Meng

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-SRG
Phone303/724-6303

    Collapse Research 
    Collapse research activities and funding
    I01BX005163     (MENG, XIANZHONG)Jan 1, 2021 - Jun 30, 2025
    NIH
    Downregulation of Inflamm-aging for Protection Against Organ Damage in Sepsis
    Role: Principal Investigator
    R01GM129641     (MENG, XIANZHONG)Sep 1, 2018 - Aug 31, 2021
    NIH
    Mechanisms of cardiac dysfunction in sepsis
    Role: Principal Investigator
    R01HL121776     (MENG, XIANZHONG)Jul 1, 2015 - Jun 30, 2024
    NIH
    Suppression of AVIC inflammosteogenesis for prevention of CAVD progression
    Role: Principal Investigator
    R01AG039545     (MENG, XIANZHONG)Sep 15, 2011 - May 31, 2017
    NIH
    Inflammatory response of aging heart to surgical myocardial ischemia
    Role: Principal Investigator
    R01HL106582     (MENG, XIANZHONG)Dec 15, 2010 - Nov 30, 2021
    NIH
    Role of inflammatory response in aortic valve lesions
    Role: Principal Investigator
    R01HL079051     (MENG, XIANZHONG)Jun 1, 2005 - Apr 30, 2011
    NIH
    TLR4 and cardiac inflammatory response to I/R
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhai Y, Yao Q, The E, Ao L, Fullerton DA, Meng X. Aging exacerbates cardiac dysfunction and mortality in sepsis through enhancing TLR2 activity. Front Cardiovasc Med. 2023; 10:1293866. PMID: 38094127.
      View in: PubMed
    2. The E, Zhai Y, Yao Q, Ao L, Li S, Fullerton DA, Dinarello CA, Meng X. Recombinant IL-37 Exerts an Anti-inflammatory Effect on Human Aortic Valve Interstitial Cells through Extracellular and Intracellular Actions. Int J Biol Sci. 2023; 19(12):3908-3919. PMID: 37564205.
      View in: PubMed
    3. Deng XS, Meng X, Fullerton D, Stone M, Iguidbashian J, Jaggers J. Complement Cross Talks With H-K-ATPase to Upregulate Runx2 in Human Aortic Valve Interstitial Cells. J Surg Res. 2023 06; 286:118-126. PMID: 36822134.
      View in: PubMed
    4. The E, de Graaf DM, Zhai Y, Yao Q, Ao L, Fullerton DA, Dinarello CA, Meng X. Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2202577119. PMID: 36037361.
      View in: PubMed
    5. Zhai Y, Ao L, Yao Q, The E, Fullerton DA, Meng X. Elevated Expression of TLR2 in Aging Hearts Exacerbates Cardiac Inflammatory Response and Adverse Remodeling Following Ischemia and Reperfusion Injury. Front Immunol. 2022; 13:891570. PMID: 35493479.
      View in: PubMed
    6. Luo Z, The E, Zhang P, Zhai Y, Yao Q, Ao L, Zeng Q, Fullerton DA, Meng X. Monocytes augment inflammatory responses in human aortic valve interstitial cells via ?2-integrin/ICAM-1-mediated signaling. Inflamm Res. 2022 Jun; 71(5-6):681-694. PMID: 35411432.
      View in: PubMed
    7. Zhang P, The E, Luo Z, Zhai Y, Yao Q, Ao L, Fullerton DA, Xu D, Meng X. Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity. Mol Med. 2022 01 21; 28(1):5. PMID: 35062861.
      View in: PubMed
    8. Gergen AK, Madsen HJ, Li A, Cheng L, Meng X, Fullerton DA, Pratap A, Weyant MJ. Simvastatin Inhibits Histologic Changes Associated with Gastroduodenal Reflux in a Murine Model. Dig Dis Sci. 2022 Oct; 67(10):4732-4741. PMID: 35001242.
      View in: PubMed
    9. Gergen AK, Jarrett MJ, Li A, Meng X, Pratap A, Fullerton DA, Weyant MJ. Toll-like Receptor 4 Mediates Reflux-Induced Inflammation in a Murine Reflux Model. Semin Thorac Cardiovasc Surg. 2022; 34(4):1324-1335. PMID: 34534678.
      View in: PubMed
    10. Zhao P, Yao Q, Zhang PJ, The E, Zhai Y, Ao L, Jarrett MJ, Dinarello CA, Fullerton DA, Meng X. Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery-on-a-chip. Sci Adv. 2021 08; 7(34). PMID: 34417174.
      View in: PubMed
    11. Venardos N, Gergen AK, Jarrett M, Weyant MJ, Reece TB, Meng X, Fullerton DA. Warfarin Induces Calcification of the Aortic Valve Through Extracellular Signal-regulated Kinase 1/2 and ?-catenin Signaling. Ann Thorac Surg. 2022 03; 113(3):824-835. PMID: 33901456.
      View in: PubMed
    12. Gergen AK, Jarrett MJ, Li A, Cheng L, Tilva KR, Madsen HJ, Meng X, Fullerton DA, Weyant MJ. Expression of Adhesion Molecules in a Gastroduodenal Reflux Murine Model. Ann Thorac Surg. 2022 03; 113(3):926-933. PMID: 33774002.
      View in: PubMed
    13. Gergen AK, Kohtz PD, Halpern AL, White AM, Meng X, Fullerton DA, Weyant MJ. Statins Inhibit Toll-Like Receptor 4-Mediated Growth of Human Esophageal Adenocarcinoma Cells. J Surg Res. 2021 04; 260:436-447. PMID: 33272595.
      View in: PubMed
    14. Gergen AK, Jarrett MJ, Li A, White AM, Meng X, Fullerton DA, Weyant MJ. Secretory Phospholipase A2 Inhibition Attenuates Adhesive Properties of Esophageal Barrett's Cells. J Surg Res. 2021 03; 259:562-568. PMID: 33261858.
      View in: PubMed
    15. Jarrett MJ, Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DA. Wnt Signaling Mediates Pro-Fibrogenic Activity in Human Aortic Valve Interstitial?Cells. Ann Thorac Surg. 2021 08; 112(2):519-525. PMID: 33189669.
      View in: PubMed
    16. Zhang P, The E, Nedumaran B, Ao L, Jarrett MJ, Xu D, Fullerton DA, Meng X. Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level. Int J Biol Sci. 2020; 16(15):3062-3074. PMID: 33061818.
      View in: PubMed
    17. Gergen AK, Kohtz PD, Halpern AL, Li A, Meng X, Reece TB, Fullerton DA, Weyant MJ. Activation of Toll-Like Receptor 2 Promotes Proliferation of Human Lung Adenocarcinoma Cells. Anticancer Res. 2020 Oct; 40(10):5361-5369. PMID: 32988855.
      View in: PubMed
    18. Halpern AL, Kohtz PD, White AM, Houk AK, Rehring JF, Hanson L, McCarter MD, Joshi M, Meng X, Fullerton DA, Weyant MJ. Secretory Phospholipase A2 IIa Mediates Expression of Growth Factor Receptors in Esophageal Adenocarcinoma. Dig Dis Sci. 2021 03; 66(3):784-795. PMID: 32277371.
      View in: PubMed
    19. Yao Q, The E, Ao L, Zhai Y, Osterholt MK, Fullerton DA, Meng X. TLR4 Stimulation Promotes Human AVIC Fibrogenic Activity through Upregulation of Neurotrophin 3 Production. Int J Mol Sci. 2020 Feb 14; 21(4). PMID: 32074942.
      View in: PubMed
    20. The E, Yao Q, Zhang P, Zhai Y, Ao L, Fullerton DA, Meng X. Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells. Cells. 2020 02 07; 9(2). PMID: 32046115.
      View in: PubMed
    21. Song R, Zhai Y, Ao L, Fullerton DA, Meng X. MicroRNA-204 Deficiency in Human Aortic Valves Elevates Valvular Osteogenic Activity. Int J Mol Sci. 2019 Dec 20; 21(1). PMID: 31861929.
      View in: PubMed
    22. Jarrett MJ, Yao Q, Venardos N, Weyant MJ, Reece TB, Meng X, Fullerton DA. Simvastatin down-regulates osteogenic response in cultured human aortic valve interstitial cells. J Thorac Cardiovasc Surg. 2021 04; 161(4):e261-e271. PMID: 31924353.
      View in: PubMed
    23. Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Nix JC, Azam T, Zhang L, Zhao R, Kieft JS, The E, Meng X, Dinarello CA. Interleukin-37 monomer is the active form for reducing innate immunity. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5514-5522. PMID: 30819901.
      View in: PubMed
    24. Halpern AL, Kohtz PD, Rove JY, Ao L, Meng X, Fullerton DA, Weyant MJ. Inhibition of secretory phospholipase A2 IIa attenuates prostaglandin E2-induced invasiveness in lung adenocarcinoma. Mol Cell Biochem. 2019 Jun; 456(1-2):145-156. PMID: 30684134.
      View in: PubMed
    25. Lee DJ, Cavasin MA, Rocker AJ, Soranno DE, Meng X, Shandas R, Park D. An injectable sulfonated reversible thermal gel for therapeutic angiogenesis to protect cardiac function after a myocardial infarction. J Biol Eng. 2019; 13:6. PMID: 30675179.
      View in: PubMed
    26. Deng XS, Meng X, Li F, Venardos N, Fullerton D, Jaggers J. MMP-12-Induced Pro-osteogenic Responses in Human Aortic Valve Interstitial Cells. J Surg Res. 2019 03; 235:44-51. PMID: 30691826.
      View in: PubMed
    27. Kohtz PD, Halpern AL, Eldeiry MA, Hazel K, Kalatardi S, Ao L, Meng X, Reece TB, Fullerton DA, Weyant MJ. Toll-Like Receptor-4 Is a Mediator of Proliferation in Esophageal Adenocarcinoma. Ann Thorac Surg. 2019 01; 107(1):233-241. PMID: 30292843.
      View in: PubMed
    28. Yamanaka K, Eldeiry M, Aftab M, Ryan TJ, Mares J, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB. Synergistic Reduction of Apoptosis With Diazoxide and Erythropoietin in Spinal Cord Ischemic Injury. Ann Thorac Surg. 2018 12; 106(6):1751-1758. PMID: 30193997.
      View in: PubMed
    29. Venardos N, Deng XS, Yao Q, Weyant MJ, Reece TB, Meng X, Fullerton DA. Simvastatin reduces the TLR4-induced inflammatory response in human aortic valve interstitial cells. J Surg Res. 2018 10; 230:101-109. PMID: 30100024.
      View in: PubMed
    30. Yamanaka K, Eldeiry M, Aftab M, Mares J, Ryan TJ, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB. Optimized induction of beta common receptor enhances the neuroprotective function of erythropoietin in spinal cord ischemic injury. J Thorac Cardiovasc Surg. 2018 06; 155(6):2505-2516. PMID: 29523405.
      View in: PubMed
    31. Li F, Song R, Ao L, Reece TB, Cleveland JC, Dong N, Fullerton DA, Meng X. ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells. Arterioscler Thromb Vasc Biol. 2017 07; 37(7):1339-1351. PMID: 28546218.
      View in: PubMed
    32. Song R, Fullerton DA, Ao L, Zhao KS, Reece TB, Cleveland JC, Meng X. Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves. J Am Heart Assoc. 2017 Apr 24; 6(4). PMID: 28438736.
      View in: PubMed
    33. Song R, Fullerton DA, Ao L, Zhao KS, Meng X. An epigenetic regulatory loop controls pro-osteogenic activation by TGF-?1 or bone morphogenetic protein 2 in human aortic valve interstitial cells. J Biol Chem. 2017 05 26; 292(21):8657-8666. PMID: 28377507.
      View in: PubMed
    34. Yao Q, Song R, Ao L, Cleveland JC, Fullerton DA, Meng X. Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis. Am J Physiol Cell Physiol. 2017 Jun 01; 312(6):C697-C706. PMID: 28356268.
      View in: PubMed
    35. Zhan Q, Zeng Q, Song R, Zhai Y, Xu D, Fullerton DA, Dinarello CA, Meng X. IL-37 suppresses MyD88-mediated inflammatory responses in human aortic valve interstitial cells. Mol Med. 2017 05; 23:83-91. PMID: 28362018.
      View in: PubMed
    36. Li F, Yao Q, Ao L, Cleveland JC, Dong N, Fullerton DA, Meng X. Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9. J Mol Med (Berl). 2017 07; 95(7):739-751. PMID: 28332126.
      View in: PubMed
    37. Cheng H, Yao Q, Song R, Zhai Y, Wang W, Fullerton DA, Meng X. Lysophosphatidylcholine activates the Akt pathway to upregulate extracellular matrix protein production in human aortic valve cells. J Surg Res. 2017 06 01; 213:243-250. PMID: 28601321.
      View in: PubMed
    38. Hui H, Zhai Y, Ao L, Cleveland JC, Liu H, Fullerton DA, Meng X. Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget. 2017 Feb 28; 8(9):15663-15676. PMID: 28152512.
      View in: PubMed
    39. Li J, Zhai Y, Ao L, Hui H, Fullerton DA, Dinarello CA, Meng X. Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice. Cytokine. 2017 07; 95:55-63. PMID: 28237874.
      View in: PubMed
    40. Zeng Q, Song R, Fullerton DA, Ao L, Zhai Y, Li S, Ballak DB, Cleveland JC, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng X. Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1631-1636. PMID: 28137840.
      View in: PubMed
    41. Zhan Q, Song R, Li F, Ao L, Zeng Q, Xu D, Fullerton DA, Meng X. Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-?B pathway. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C407-C417. PMID: 28052863.
      View in: PubMed
    42. Ao L, Zhai Y, Jin C, Cleveland JC, Fullerton DA, Meng X. Attenuated recovery of contractile function in aging hearts following global ischemia/reperfusion: Role of extracellular HSP27 and TLR4. Mol Med. 2017 Jan; 23:863-872. PMID: 28079228.
      View in: PubMed
    43. Lee DJ, Fontaine A, Meng X, Park D. Biomimetic Nerve Guidance Conduit Containing Intraluminal Microchannels with Aligned Nanofibers Markedly Facilitates in Nerve Regeneration. ACS Biomater Sci Eng. 2016 Aug 08; 2(8):1403-1410. PMID: 33434994.
      View in: PubMed
    44. Li J, Ao L, Zhai Y, Cleveland JC, Fullerton DA, Meng X. Gender disparity in the role of TLR2 in post-ischemic myocardial inflammation and injury. Int J Clin Exp Med. 2015; 8(7):10537-47. PMID: 26379843.
      View in: PubMed
    45. Yao Q, Song R, Ao L, Zhan Q, Cleveland JC, Yu X, Fullerton DA, Meng X. Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway. Biochim Biophys Acta. 2015 Sep; 1852(9):1940-9. PMID: 26122822.
      View in: PubMed
    46. Venardos N, Bennett D, Weyant MJ, Reece TB, Meng X, Fullerton DA. Matrix Gla protein regulates calcification of the aortic valve. J Surg Res. 2015 Nov; 199(1):1-6. PMID: 25990696.
      View in: PubMed
    47. Foley LS, Fullerton DA, Bennett DT, Freeman KA, Mares J, Bell MT, Cleveland JC, Weyant MJ, Meng X, Puskas F, Reece TB. Spinal Cord Ischemia-Reperfusion Injury Induces Erythropoietin Receptor Expression. Ann Thorac Surg. 2015 Jul; 100(1):41-6; discussion 46. PMID: 25865765.
      View in: PubMed
    48. Zhai Y, Ao L, Cleveland JC, Zeng Q, Reece TB, Fullerton DA, Meng X. Toll-like receptor 4 mediates the inflammatory responses and matrix protein remodeling in remote non-ischemic myocardium in a mouse model of myocardial ischemia and reperfusion. PLoS One. 2015; 10(3):e0121853. PMID: 25823011.
      View in: PubMed
    49. Zhan Q, Song R, Zeng Q, Yao Q, Ao L, Xu D, Fullerton DA, Meng X. Activation of TLR3 induces osteogenic responses in human aortic valve interstitial cells through the NF-?B and ERK1/2 pathways. Int J Biol Sci. 2015; 11(4):482-93. PMID: 25798067.
      View in: PubMed
    50. Freeman KA, Puskas F, Bell MT, Mares JM, Foley LS, Weyant MJ, Cleveland JC, Fullerton DA, Meng X, Herson PS, Reece TB. Alpha-2 agonist attenuates ischemic injury in spinal cord neurons. J Surg Res. 2015 May 01; 195(1):21-8. PMID: 25655994.
      View in: PubMed
    51. Song R, Fullerton DA, Ao L, Zheng D, Zhao KS, Meng X. BMP-2 and TGF-?1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells. J Mol Med (Berl). 2015 Apr; 93(4):403-12. PMID: 25412776.
      View in: PubMed
    52. Deng XS, Meng X, Zeng Q, Fullerton D, Mitchell M, Jaggers J. Adult aortic valve interstitial cells have greater responses to toll-like receptor 4 stimulation. Ann Thorac Surg. 2015 Jan; 99(1):62-71. PMID: 25442996.
      View in: PubMed
    53. Freeman KA, Fullerton DA, Foley LS, Bell MT, Cleveland JC, Weyant MJ, Mares J, Meng X, Puskas F, Reece TB. Spinal cord protection via alpha-2 agonist-mediated increase in glial cell-line-derived neurotrophic factor. J Thorac Cardiovasc Surg. 2015 Feb; 149(2):578-84; discussion 584-6. PMID: 25454921.
      View in: PubMed
    54. Bennett DT, Reece TB, Foley LS, Sjoberg A, Meng X, Fullerton DA, Weyant MJ. C-terminal tensin-like protein mediates invasion of human lung cancer cells and is regulated by signal transducer and activator of?transcription 3. J Thorac Cardiovasc Surg. 2015 Jan; 149(1):369-75. PMID: 25439778.
      View in: PubMed
    55. Wang D, Zeng Q, Song R, Ao L, Fullerton DA, Meng X. Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-?B pathway in BMP-2 expression. Biochim Biophys Acta. 2014 Nov; 1843(11):2744-53. PMID: 25101972.
      View in: PubMed
    56. Bennett DT, Deng XS, Yu JA, Bell MT, Mauchley DC, Meng X, Reece TB, Fullerton DA, Weyant MJ. Cancer stem cell phenotype is supported by secretory phospholipase A2 in human lung cancer cells. Ann Thorac Surg. 2014 Aug; 98(2):439-45; discussion 445-6. PMID: 24928671.
      View in: PubMed
    57. Jin C, Cleveland JC, Ao L, Li J, Zeng Q, Fullerton DA, Meng X. Human myocardium releases heat shock protein 27 (HSP27) after global ischemia: the proinflammatory effect of extracellular HSP27 through toll-like receptor (TLR)-2 and TLR4. Mol Med. 2014 Jun 09; 20:280-9. PMID: 24918749.
      View in: PubMed
    58. Song R, Ao L, Zhao KS, Zheng D, Venardos N, Fullerton DA, Meng X. Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway. Inflamm Res. 2014 Sep; 63(9):703-10. PMID: 24875140.
      View in: PubMed
    59. Zeng Q, Song R, Ao L, Xu D, Venardos N, Fullerton DA, Meng X. Augmented osteogenic responses in human aortic valve cells exposed to oxLDL and TLR4 agonist: a mechanistic role of Notch1 and NF-?B interaction. PLoS One. 2014; 9(5):e95400. PMID: 24810405.
      View in: PubMed
    60. Venardos N, Nadlonek NA, Zhan Q, Weyant MJ, Reece TB, Meng X, Fullerton DA. Aortic valve calcification is mediated by a differential response of aortic valve interstitial cells to inflammation. J Surg Res. 2014 Jul; 190(1):1-8. PMID: 24746950.
      View in: PubMed
    61. Bell MT, Puskas F, Agoston VA, Cleveland JC, Freeman KA, Gamboni F, Herson PS, Meng X, Smith PD, Weyant MJ, Fullerton DA, Reece TB. Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury. Circulation. 2013 Sep 10; 128(11 Suppl 1):S152-6. PMID: 24030400.
      View in: PubMed
    62. Nadlonek N, Lee JH, Reece TB, Weyant MJ, Cleveland JC, Meng X, Fullerton DA. Interleukin-1 Beta induces an inflammatory phenotype in human aortic valve interstitial cells through nuclear factor kappa Beta. Ann Thorac Surg. 2013 Jul; 96(1):155-62. PMID: 23735716.
      View in: PubMed
    63. Nadlonek NA, Lee JH, Weyant MJ, Meng X, Fullerton DA. ox-LDL induces PiT-1 expression in human aortic valve interstitial cells. J Surg Res. 2013 Sep; 184(1):6-9. PMID: 23849774.
      View in: PubMed
    64. Zeng Q, Song R, Ao L, Weyant MJ, Lee J, Xu D, Fullerton DA, Meng X. Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and nuclear factor-?B activation. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1580-90. PMID: 23640488.
      View in: PubMed
    65. Smith PD, Bell MT, Puskas F, Meng X, Cleveland JC, Weyant MJ, Fullerton DA, Reece TB. Preservation of motor function after spinal cord ischemia and reperfusion injury through microglial inhibition. Ann Thorac Surg. 2013 May; 95(5):1647-53. PMID: 23541432.
      View in: PubMed
    66. Yu JA, Mauchley D, Li H, Meng X, Nemenoff RA, Fullerton DA, Weyant MJ. Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo. J Thorac Cardiovasc Surg. 2012 Nov; 144(5):1185-91. PMID: 23079010.
      View in: PubMed
    67. Yu JA, Li H, Meng X, Fullerton DA, Nemenoff RA, Mitchell JD, Weyant MJ. Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells. J Thorac Cardiovasc Surg. 2012 Dec; 144(6):1479-85. PMID: 23026567.
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    68. Nadlonek NA, Weyant MJ, Yu JA, Cleveland JC, Reece TB, Meng X, Fullerton DA. Radiation induces osteogenesis in human aortic valve interstitial cells. J Thorac Cardiovasc Surg. 2012 Dec; 144(6):1466-70. PMID: 23026565.
      View in: PubMed
    69. Song R, Zeng Q, Ao L, Yu JA, Cleveland JC, Zhao KS, Fullerton DA, Meng X. Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like receptor-2. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2711-20. PMID: 22982459.
      View in: PubMed
    70. Zeng Q, Jin C, Ao L, Cleveland JC, Song R, Xu D, Fullerton DA, Meng X. Cross-talk between the Toll-like receptor 4 and Notch1 pathways augments the inflammatory response in the interstitial cells of stenotic human aortic valves. Circulation. 2012 Sep 11; 126(11 Suppl 1):S222-30. PMID: 22965987.
      View in: PubMed
    71. Yu JA, Kalatardi S, Dohse J, Sadaria MR, Meng X, Fullerton DA, Weyant MJ. Group IIa sPLA2 inhibition attenuates NF-?B activity and promotes apoptosis of lung cancer cells. Anticancer Res. 2012 Sep; 32(9):3601-7. PMID: 22993297.
      View in: PubMed
    72. Bell MT, Puskas F, Smith PD, Agoston VA, Fullerton DA, Meng X, Weyant MJ, Reece TB. Attenuation of spinal cord ischemia-reperfusion injury by specific a-2a receptor activation with dexmedetomidine. J Vasc Surg. 2012 Nov; 56(5):1398-402. PMID: 22832266.
      View in: PubMed
    73. Eun JC, Moore EE, Mauchley DC, Johnson CA, Meng X, Banerjee A, Wohlauer MV, Zarini S, Gij?n MA, Murphy RC. The 5-lipoxygenase pathway is required for acute lung injury following hemorrhagic shock. Shock. 2012 Jun; 37(6):599-604. PMID: 22392149.
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    74. Yu JA, Sadaria MR, Meng X, Mitra S, Ao L, Fullerton DA, Weyant MJ. Lung cancer cell invasion and expression of intercellular adhesion molecule-1 (ICAM-1) are attenuated by secretory phospholipase A2 inhibition. J Thorac Cardiovasc Surg. 2012 Feb; 143(2):405-11. PMID: 22248682.
      View in: PubMed
    75. Sadaria MR, Reppert AE, Yu JA, Meng X, Fullerton DA, Reece TB, Weyant MJ. Statin therapy attenuates growth and malignant potential of human esophageal adenocarcinoma cells. J Thorac Cardiovasc Surg. 2011 Nov; 142(5):1152-60. PMID: 22014341.
      View in: PubMed
    76. Abohashem-Aly AA, Meng X, Li J, Sadaria MR, Ao L, Wennergren J, Fullerton DA, Raeburn CD. DITPA, a thyroid hormone analog, reduces infarct size and attenuates the inflammatory response following myocardial ischemia. J Surg Res. 2011 Dec; 171(2):379-85. PMID: 21658725.
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    77. Smith PD, Puskas F, Meng X, Cho D, Cleveland JC, Weyant MJ, Watkins MT, Fullerton DA, Reece TB. Ischemic dose-response in the spinal cord: both immediate and delayed paraplegia. J Surg Res. 2012 May 15; 174(2):238-44. PMID: 21543089.
      View in: PubMed
    78. Sadaria MR, Meng X, Fullerton DA, Reece TB, Shah RR, Grover FL, Weyant MJ. Secretory phospholipase A2 inhibition attenuates intercellular adhesion molecule-1 expression in human esophageal adenocarcinoma cells. Ann Thorac Surg. 2011 May; 91(5):1539-45. PMID: 21396625.
      View in: PubMed
    79. Su X, Ao L, Shi Y, Johnson TR, Fullerton DA, Meng X. Oxidized low density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via Toll-like receptors 2 and 4. J Biol Chem. 2011 Apr 08; 286(14):12213-20. PMID: 21325271.
      View in: PubMed
    80. Smith PD, Puskas F, Fullerton DA, Meng X, Cho D, Cleveland JC, Weyant MJ, Reece TB. Attenuation of spinal cord ischemia and reperfusion injury by erythropoietin. J Thorac Cardiovasc Surg. 2011 Jan; 141(1):256-60. PMID: 21168028.
      View in: PubMed
    81. Li J, Jin C, Cleveland JC, Ao L, Xu D, Fullerton DA, Meng X. Enhanced inflammatory responses to toll-like receptor 2/4 stimulation in type 1 diabetic coronary artery endothelial cells: the effect of insulin. Cardiovasc Diabetol. 2010 Dec 16; 9:90. PMID: 21162749.
      View in: PubMed
    82. Su X, Sykes JB, Ao L, Raeburn CD, Fullerton DA, Meng X. Extracellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin: differential effect on TNF-alpha and ICAM-1 levels in heart tissue. Cytokine. 2010 Jul; 51(1):60-6. PMID: 20478717.
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    83. Mauchley D, Meng X, Johnson T, Teitelbaum J, Babu A, Fullerton DA, Weyant MJ. Heat shock protein 27: induction by gastroduodenal reflux in vivo and augmentation of human esophageal mucosal cell growth in vitro. J Thorac Cardiovasc Surg. 2010 Apr; 139(4):1019-25. PMID: 20304146.
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    84. Mauchley D, Meng X, Johnson T, Fullerton DA, Weyant MJ. Modulation of growth in human esophageal adenocarcinoma cells by group IIa secretory phospholipase A(2). J Thorac Cardiovasc Surg. 2010 Mar; 139(3):591-9; discussion 599. PMID: 20176206.
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    85. Mauchley D, Meng X, Babu A, Gamboni-Robertson F, Yang X, Banerjee A, Fullerton DA, Weyant MJ. Gastroduodenal reflux induces group IIa secretory phospholipase A(2) expression and activity in murine esophagus. Dis Esophagus. 2010 Jul; 23(5):430-6. PMID: 20095996.
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    86. Babu A, Mauchley D, Meng X, Banerjee AM, Gamboni-Robertson F, Fullerton DA, Weyant MJ. The secretory phospholipase A2 gene is required for gastroesophageal reflux-related changes in murine esophagus. J Gastrointest Surg. 2009 Dec; 13(12):2212-8. PMID: 19672667.
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    87. Yang X, Meng X, Su X, Mauchley DC, Ao L, Cleveland JC, Fullerton DA. Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2. J Thorac Cardiovasc Surg. 2009 Oct; 138(4):1008-15. PMID: 19664780.
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    88. Ao L, Zou N, Cleveland JC, Fullerton DA, Meng X. Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H21-8. PMID: 19448144.
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    89. Song Y, Fullerton DA, Mauchley D, Su X, Ao L, Yang X, Cleveland JC, Meng X. Microfilaments facilitate TLR4-mediated ICAM-1 expression in human aortic valve interstitial cells. J Surg Res. 2011 Mar; 166(1):52-8. PMID: 19691982.
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    90. Damle SS, Moore EE, Babu AN, Meng X, Fullerton DA, Banerjee A. Hemoglobin-based oxygen carrier induces heme oxygenase-1 in the heart and lung but not brain. J Am Coll Surg. 2009 Apr; 208(4):592-8. PMID: 19476795.
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    91. Yang X, Fullerton DA, Su X, Ao L, Cleveland JC, Meng X. Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2. J Am Coll Cardiol. 2009 Feb 10; 53(6):491-500. PMID: 19195606.
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    92. Babu AN, Meng X, Zou N, Yang X, Wang M, Song Y, Cleveland JC, Weyant M, Banerjee A, Fullerton DA. Lipopolysaccharide stimulation of human aortic valve interstitial cells activates inflammation and osteogenesis. Ann Thorac Surg. 2008 Jul; 86(1):71-6. PMID: 18573401.
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    93. Babu A, Meng X, Banerjee AM, Gamboni-Robertson F, Cleveland JC, Damle S, Fullerton DA, Weyant MJ. Secretory phospholipase A2 is required to produce histologic changes associated with gastroduodenal reflux in a murine model. J Thorac Cardiovasc Surg. 2008 Jun; 135(6):1220-7. PMID: 18544357.
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    94. Cha J, Wang Z, Ao L, Zou N, Dinarello CA, Banerjee A, Fullerton DA, Meng X. Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia. Ann Thorac Surg. 2008 May; 85(5):1678-85. PMID: 18442564.
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    95. Zou N, Ao L, Cleveland JC, Yang X, Su X, Cai GY, Banerjee A, Fullerton DA, Meng X. Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2008 Jun; 294(6):H2805-13. PMID: 18441202.
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    96. Meng X, Ao L, Song Y, Babu A, Yang X, Wang M, Weyant MJ, Dinarello CA, Cleveland JC, Fullerton DA. Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C29-35. PMID: 17942642.
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    97. Babu AN, Damle SS, Moore EE, Ao L, Song Y, Johnson JL, Weyant M, Banerjee A, Meng X, Fullerton DA. Hemoglobin-based oxygen carrier induces hepatic heme oxygenase 1 expression in Kupffer cells. Surgery. 2007 Aug; 142(2):289-94. PMID: 17689698.
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    98. Ao L, Song Y, Fullerton DA, Dinarello CA, Meng X. The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction: role of TNF-alpha in TLR4-mediated ICAM-1 expression. Cytokine. 2007 Jun; 38(3):124-9. PMID: 17683945.
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    99. Netea MG, Azam T, Lewis EC, Joosten LA, Wang M, Langenberg D, Meng X, Chan ED, Yoon DY, Ottenhoff T, Kim SH, Dinarello CA. Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism. PLoS Med. 2006 Aug; 3(8):e277. PMID: 16903774.
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    100. Singleton KD, Serkova N, Banerjee A, Meng X, Gamboni-Robertson F, Wischmeyer PE. Glutamine attenuates endotoxin-induced lung metabolic dysfunction: potential role of enhanced heat shock protein 70. Nutrition. 2005 Feb; 21(2):214-23. PMID: 15723751.
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    101. Meng X, Ao L, Song Y, Raeburn CD, Fullerton DA, Harken AH. Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor. Am J Physiol Regul Integr Comp Physiol. 2005 Mar; 288(3):R600-6. PMID: 15514106.
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    102. Silliman CC, Moore EE, Zallen G, Gonzalez R, Johnson JL, Elzi DJ, Meng X, Hanasaki K, Ishizaki J, Arita H, Ao L, England KM, Banerjee A. Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion. Am J Physiol Cell Physiol. 2002 Oct; 283(4):C1102-13. PMID: 12225974.
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    103. Raeburn CD, Calkins CM, Zimmerman MA, Song Y, Ao L, Banerjee A, Harken AH, Meng X. ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation. Am J Physiol Regul Integr Comp Physiol. 2002 Aug; 283(2):R477-86. PMID: 12121861.
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    104. Zimmerman MA, Selzman CH, Reznikov LL, Miller SA, Raeburn CD, Emmick J, Meng X, Harken AH. Lack of TNF-alpha attenuates intimal hyperplasia after mouse carotid artery injury. Am J Physiol Regul Integr Comp Physiol. 2002 Aug; 283(2):R505-12. PMID: 12121864.
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    105. Raeburn CD, Dinarello CA, Zimmerman MA, Calkins CM, Pomerantz BJ, McIntyre RC, Harken AH, Meng X. Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H650-7. PMID: 12124212.
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    106. Calkins CM, Barsness K, Bensard DD, Vasquez-Torres A, Raeburn CD, Meng X, McIntyre RC. Toll-like receptor-4 signaling mediates pulmonary neutrophil sequestration in response to gram-positive bacterial enterotoxin. J Surg Res. 2002 May 15; 104(2):124-30. PMID: 12020131.
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    107. Meng X, Harken AH. The interaction between Hsp70 and TNF-alpha expression: a novel mechanism for protection of the myocardium against post-injury depression. Shock. 2002 May; 17(5):345-53. PMID: 12022752.
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    108. Calkins CM, Bensard DD, Shames BD, Pulido EJ, Abraham E, Fernandez N, Meng X, Dinarello CA, McIntyre RC. IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia. J Endotoxin Res. 2002; 8(1):59-67. PMID: 11981446.
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