Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Curtis J. Henry

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-3231

    Collapse Research 
    Collapse research activities and funding
    K01CA160798     (HENRY, CURTIS JAMES)Sep 7, 2012 - Aug 31, 2018
    NIH
    Dissecting the relationship between declining lymphoid progenitor fitness and agi
    Role: Principal Investigator
    F31AI073245     (HENRY, CURTIS JAMES)Jul 1, 2007 - Jun 30, 2010
    NIH
    Dissecting the Role of IL-12 in Naive CD8+ T cell Activation by Dendritic Cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Henry CJ, DeGregori J. Modelling the ageing dependence of cancer evolutionary trajectories. Nat Rev Cancer. 2025 Oct; 25(10):757-780. PMID: 40640377.
      View in: PubMed
    2. Huelse JM, Bhasin SS, Jacobsen KM, Yim J, Thomas BE, Branella GM, Bakhtiari M, Chimenti ML, Baxter TA, Raikar SS, Wang X, Frye SV, Henry CJ, Earp HS, Bhasin M, DeRyckere D, Graham DK. MERTK inhibition selectively activates a DC - T-cell axis to provide anti-leukemia immunity. Leukemia. 2024 Dec; 38(12):2685-2698. PMID: 39322710.
      View in: PubMed
    3. Zhu Y, Banerjee A, Xie P, Ivanov AA, Uddin A, Jiao Q, Chi JJ, Zeng L, Lee JY, Xue Y, Lu X, Cristofanilli M, Gradishar WJ, Henry CJ, Gillespie TW, Bhave MA, Kalinsky K, Fu H, Bahar I, Zhang B, Wan Y. Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers. J Clin Invest. 2024 Mar 26; 134(10). PMID: 38530357.
      View in: PubMed
    4. Kellner AV, Hunter R, Do P, Eggert J, Jaffe M, Geitgey DK, Lee M, Hamilton JAG, Ross AJ, Ank RS, Bender RL, Ma R, Porter CC, Dreaden EC, Au-Yeung BB, Haynes KA, Henry CJ, Salaita K. The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces. bioRxiv. 2024 Feb 02. PMID: 38352441.
      View in: PubMed
    5. Townsel A, Jaffe M, Wu Y, Henry CJ, Haynes KA. The Epigenetic Landscape of Breast Cancer, Metabolism, and Obesity. Adv Exp Med Biol. 2024; 1465:37-53. PMID: 39586992.
      View in: PubMed
    6. Shim J, Park S, Venkateswaran S, Kumar D, Prince C, Parihar V, Maples L, Waller EK, Kugathasan S, Briones M, Lee M, Henry CJ, Prahalad S, Chandrakasan S. Early B-cell development and B-cell maturation are impaired in patients with active hemophagocytic lymphohistiocytosis. Blood. 2023 12 07; 142(23):1972-1984. PMID: 37624902.
      View in: PubMed
    7. Pillsbury CE, Dougan J, Rabe JL, Fonseca JA, Zhou C, Evans AN, Abukharma H, Ichoku O, Gonzalez-Flamenco G, Park SI, Aljudi A, DeRyckere D, Castellino SM, Rafiq S, Langermann S, Liu LN, Henry CJ, Porter CC. Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia. Cancer Res Commun. 2023 07; 3(7):1248-1259. PMID: 37465593.
      View in: PubMed
    8. Townsel A, Henry CJ. Sex, aging, immunity and adrenal cancer. Nat Aging. 2023 07; 3(7):764-765. PMID: 37291221.
      View in: PubMed
    9. Cash T, Jonus HC, Tsvetkova M, Beumer JH, Sadanand A, Lee JY, Henry CJ, Aguilera D, Harvey RD, Goldsmith KC. A phase 1 study of simvastatin in combination with topotecan and cyclophosphamide in pediatric patients with relapsed and/or refractory solid and CNS tumors. Pediatr Blood Cancer. 2023 08; 70(8):e30405. PMID: 37158620.
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    10. Birnbaum LA, Sullivan EC, Do P, Uricoli B, Raikar SS, Porter CC, Henry CJ, Dreaden EC. Multicolor Light-Induced Immune Activation via Polymer Photocaged Cytokines. Biomacromolecules. 2023 03 13; 24(3):1164-1172. PMID: 36745712.
      View in: PubMed
    11. Lee M, Geitgey DK, Hamilton JAG, Boss JM, Scharer CD, Spangle JM, Haynes KA, Henry CJ. Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs. Front Cell Dev Biol. 2022; 10:909557. PMID: 36060800.
      View in: PubMed
    12. Hunter R, Imbach KJ, Zhou C, Dougan J, Hamilton JAG, Chen KZ, Do P, Townsel A, Gibson G, Dreaden EC, Waller EK, Haynes KA, Henry CJ, Porter CC. B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12. Sci Rep. 2022 07 13; 12(1):11870. PMID: 35831470.
      View in: PubMed
    13. Zhou C, Uluisik R, Rowley JW, David C, Jones CL, Scharer CD, Noetzli L, Fisher MH, Kirkpatrick GD, Bark K, Boss JM, Henry CJ, Pietras EM, Di Paola J, Porter CC. Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors. Exp Hematol. 2022 Aug-Sep; 112-113:24-34. PMID: 35803545.
      View in: PubMed
    14. Lee M, Hamilton JAG, Talekar GR, Ross AJ, Michael L, Rupji M, Dwivedi B, Raikar SS, Boss J, Scharer CD, Graham DK, DeRyckere D, Porter CC, Henry CJ. Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia. Nat Commun. 2022 03 03; 13(1):1157. PMID: 35241678.
      View in: PubMed
    15. Hamilton JAG, Lee MY, Hunter R, Ank RS, Story JY, Talekar G, Sisroe T, Ballak DB, Fedanov A, Porter CC, Eisenmesser EZ, Dinarello CA, Raikar SS, DeGregori J, Henry CJ. Interleukin-37 improves T-cell-mediated immunity and chimeric antigen receptor T-cell therapy in aged backgrounds. Aging Cell. 2021 02; 20(2):e13309. PMID: 33480151.
      View in: PubMed
    16. Pulous FE, Carnevale JC, Al-Yafeai Z, Pearson BH, Hamilton JAG, Henry CJ, Orr AW, Petrich BG. Talin-dependent integrin activation is required for endothelial proliferation and postnatal angiogenesis. Angiogenesis. 2021 02; 24(1):177-190. PMID: 33113074.
      View in: PubMed
    17. Hamilton JAG, Henry CJ. Aging and immunotherapies: New horizons for the golden ages. Aging Cancer. 2020 Dec; 1(1-4):30-44. PMID: 35874875.
      View in: PubMed
    18. Do P, Perdue LA, Chyong A, Hunter R, Dougan J, Henry CJ, Porter CC, Dreaden EC. Rapid Assembly and Screening of Multivalent Immune Cell-Redirecting Therapies for Leukemia. ACS Comb Sci. 2020 10 12; 22(10):533-541. PMID: 32786324.
      View in: PubMed
    19. Sylvetsky AC, Sen S, Merkel P, Dore F, Stern DB, Henry CJ, Cai H, Walter PJ, Crandall KA, Rother KI, Hubal MJ. Consumption of Diet Soda Sweetened with Sucralose and Acesulfame-Potassium Alters Inflammatory Transcriptome Pathways in Females with Overweight and Obesity. Mol Nutr Food Res. 2020 06; 64(11):e1901166. PMID: 32281732.
      View in: PubMed
    20. Rabe JL, Gardner L, Hunter R, Fonseca JA, Dougan J, Gearheart CM, Leibowitz MS, Lee-Miller C, Baturin D, Fosmire SP, Zelasko SE, Jones CL, Slansky JE, Rupji M, Dwivedi B, Henry CJ, Porter CC. IL12 Abrogates Calcineurin-Dependent Immune Evasion during Leukemia Progression. Cancer Res. 2019 07 15; 79(14):3702-3713. PMID: 31142509.
      View in: PubMed
    21. Lee-Sherick AB, Jacobsen KM, Henry CJ, Huey MG, Parker RE, Page LS, Hill AA, Wang X, Frye SV, Earp HS, Jordan CT, DeRyckere D, Graham DK. MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity. JCI Insight. 2018 11 02; 3(21). PMID: 30385715.
      View in: PubMed
    22. Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA. OLT1177, a ?-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1530-E1539. PMID: 29378952.
      View in: PubMed
    23. Henry CJ, Nemkov T, Cas?s-Selves M, Bilousova G, Zaberezhnyy V, Higa KC, Serkova NJ, Hansen KC, D'Alessandro A, DeGregori J. Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis. Haematologica. 2017 12; 102(12):1985-1994. PMID: 28883079.
      View in: PubMed
    24. Henry CJ, Cas?s-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J. Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest. 2015 Dec; 125(12):4666-80. PMID: 26551682.
      View in: PubMed
    25. Henry CJ, Sedjo RL, Rozhok A, Salstrom J, Ahnen D, Levin TR, D'Agostino R, Haffner S, DeGregori J, Byers T. Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma. BMC Cancer. 2015 Mar 14; 15:123. PMID: 25884547.
      View in: PubMed
    26. Bahmed K, Henry C, Holliday M, Redzic J, Ciobanu M, Zhang F, Weekes C, Sclafani R, Degregori J, Eisenmesser E. Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B. Cancer Cell Int. 2012 Jul 04; 12(1):19. PMID: 22631225.
      View in: PubMed
    27. Henry CJ, Marusyk A, DeGregori J. Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection? Aging (Albany NY). 2011 Jun; 3(6):643-56. PMID: 21765201.
      View in: PubMed
    28. Henry CJ, Marusyk A, Zaberezhnyy V, Adane B, DeGregori J. Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21713-8. PMID: 21098275.
      View in: PubMed
    29. Henry CJ, Grayson JM, Brzoza-Lewis KL, Mitchell LM, Westcott MM, Cook AS, Hiltbold EM. The roles of IL-12 and IL-23 in CD8+ T cell-mediated immunity against Listeria monocytogenes: Insights from a DC vaccination model. Cell Immunol. 2010; 264(1):23-31. PMID: 20483409.
      View in: PubMed
    30. Westcott MM, Henry CJ, Amis JE, Hiltbold EM. Dendritic cells inhibit the progression of Listeria monocytogenes intracellular infection by retaining bacteria in major histocompatibility complex class II-rich phagosomes and by limiting cytosolic growth. Infect Immun. 2010 Jul; 78(7):2956-65. PMID: 20404078.
      View in: PubMed
    31. Marusyk A, Cas?s-Selves M, Henry CJ, Zaberezhnyy V, Klawitter J, Christians U, DeGregori J. Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Res. 2009 Sep 15; 69(18):7262-9. PMID: 19738065.
      View in: PubMed
    32. Henry CJ, Ornelles DA, Mitchell LM, Brzoza-Lewis KL, Hiltbold EM. IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. J Immunol. 2008 Dec 15; 181(12):8576-84. PMID: 19050277.
      View in: PubMed
    33. Westcott MM, Henry CJ, Cook AS, Grant KW, Hiltbold EM. Differential susceptibility of bone marrow-derived dendritic cells and macrophages to productive infection with Listeria monocytogenes. Cell Microbiol. 2007 Jun; 9(6):1397-411. PMID: 17250592.
      View in: PubMed
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