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Christina Mary Coughlan

TitleAssistant Research Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-NEUR General Operations
Phone303/724-1348

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Haque PS, Goodman D, Kuusivuori-Robinson T, Coughlan C, Delgado-Deida Y, Onyiah JC, Zempleni J, Theiss AL. Obese Adipose Tissue Extracellular Vesicles Activate Mitochondrial Fatty Acid ?-oxidation to Drive Colonic Stemness. Cell Mol Gastroenterol Hepatol. 2025 Mar 22; 19(7):101504. PMID: 40122519.
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    2. Nguyen KN, Graner AN, Fringuello AR, Zizzo Z, Valenzuela L, Anyanwu K, Lillehei KO, Youssef AS, Guzman S, Coughlan C, Graner MW. Extracellular Vesicles from a Novel Chordoma Cell Line, ARF-8, Promote Tumorigenic Microenvironmental Changes When Incubated with the Parental Cells and with Human Osteoblasts. Int J Mol Sci. 2024 Nov 27; 25(23). PMID: 39684443.
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    3. Wang M, Graner AN, Knowles B, McRae C, Fringuello A, Paucek P, Gavrilovic M, Redwine M, Hanson C, Coughlan C, Grimaldo-Garcia S, Metzger B, Bolus V, Kopper TJ, Smith M, Zhou W, Lenz M, Abosch A, Ojemann S, Lillehei KO, Yu X, Graner MW. Differential Effects of Extracellular Vesicles from Two Different Glioblastomas on Normal Human Brain Cells. Neurol Int. 2024 Nov 06; 16(6):1355-1384. PMID: 39585062.
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    4. Aloy NM, Coughlan C, Graner MW, Witt SN. Possible regulation of the immune modulator tetraspanin CD81 by alpha-synuclein in melanoma. Biochem Biophys Res Commun. 2024 11 19; 734:150631. PMID: 39222576.
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    5. Burgy O, Mayr CH, Schenesse D, Fousekis Papakonstantinou E, Ballester B, Sengupta A, She Y, Hu Q, Melo-Narva?z MC, Jain E, Pestoni JC, Mozurak M, Estrada-Bernal A, Onwuka U, Coughlan C, Parimon T, Chen P, Heimerl T, Bange G, Schmeck BT, Lindner M, Hilgendorff A, Ruppert C, G?enther A, Mann M, Yildirim A?, Eickelberg O, Jung AL, Schiller HB, Lehmann M, Burgstaller G, K?nigshoff M. Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis. JCI Insight. 2024 Aug 15; 9(18). PMID: 39315549.
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    6. Bettcher BM, Lopez Paniagua D, Wang Y, McConnell BV, Coughlan C, Carlisle TC, Thaker AA, Lippitt W, Filley CM, Pelak VS, Shapiro ALB, Heffernan KS, Potter H, Solano A, Boyd J, Carlson NE. Synergistic effects of GFAP and A?42: Implications for white matter integrity and verbal memory across the cognitive spectrum. Brain Behav Immun Health. 2024 Oct; 40:100834. PMID: 39206431.
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    7. Niemeyer CS, Frietze S, Coughlan C, Lewis SWR, Bustos Lopez S, Saviola AJ, Hansen KC, Medina EM, Hassell JE, Kogut S, Traina-Dorge V, Nagel MA, Bruce KD, Restrepo D, Mahalingam R, Bubak AN. Suppression of the host antiviral response by non-infectious varicella zoster virus extracellular vesicles. J Virol. 2024 Aug 20; 98(8):e0084824. PMID: 39051773.
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    8. Sillau SH, Coughlan C, Ahmed MM, Nair K, Araya P, Galbraith MD, Bettcher BM, Espinosa JM, Chial HJ, Epperson N, Boyd TD, Potter H. Neuron loss in the brain starts in childhood, increases exponentially with age and is halted by GM-CSF treatment in Alzheimer's disease. medRxiv. 2024 Jul 15. PMID: 39072024.
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    9. Shapiro ALB, Coughlan C, Bettcher BM, Pauley ME, Kim J, Bjornstad P, Rajic B, Truong J, Bell C, Choi YJ, Walker KA, Potter H, Liese AD, Dabelea D, Whitlow CT. Biomarkers of Neurodegeneration and Alzheimer's Disease Neuropathology in Adolescents and Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: A Proof-of-Concept Study. Endocrines. 2024 Jun; 5(2):197-213. PMID: 38764894.
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    10. Wang M, Graner AN, Knowles B, McRae C, Fringuello A, Paucek P, Gavrilovic M, Redwine M, Hanson C, Coughlan C, Metzger B, Bolus V, Kopper T, Smith M, Zhou W, Lenz M, Abosch A, Ojemann S, Lillehei KO, Yu X, Graner MW. A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells. bioRxiv. 2024 Apr 12. PMID: 38645117.
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    11. Coughlan C, Lindenberger J, Jacot JG, Johnson NR, Anton P, Bevers S, Welty R, Graner MW, Potter H. Specific Binding of Alzheimer's A? Peptides to Extracellular Vesicles. Int J Mol Sci. 2024 Mar 26; 25(7). PMID: 38612514.
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    12. Fridman V, Sillau S, Ritchie A, Bockhorst J, Coughlan C, Araya P, Espinosa JM, Smith K, Lange EM, Lange LA, Ghormli LE, Drews KL, Zeitler P, Reusch JEB. Plasma neurofilament light chain concentrations are elevated in youth-onset type 2 diabetes and associated with neuropathy. J Peripher Nerv Syst. 2023 09; 28(3):460-470. PMID: 37341347.
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    13. Thaker AA, McConnell BV, Rogers DM, Carlson NE, Coughlan C, Jensen AM, Lopez-Paniagua D, Holden SK, Pressman PS, Pelak VS, Filley CM, Potter H, Solano DA, Heffernan KS, Bettcher BM. Astrogliosis, neuritic microstructure, and sex effects: GFAP is an indicator of neuritic orientation in women. Brain Behav Immun. 2023 10; 113:124-135. PMID: 37394144.
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    14. Bubak AN, Coughlan C, Posey J, Saviola AJ, Niemeyer CS, Lewis SWR, Lopez SB, Solano A, Tyring SK, Delaney C, Neeves KB, Mahalingam R, Hansen KC, Nagel MA. Zoster-Associated Prothrombotic Plasma Exosomes and Increased Stroke Risk. J Infect Dis. 2023 04 18; 227(8):993-1001. PMID: 36200236.
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    15. Colvett I, Saternos H, Coughlan C, Vielle A, Ledreux A. Extracellular vesicles from the CNS play pivotal roles in neuroprotection and neurodegeneration: lessons from in vitro experiments. Extracell Vesicles Circ Nucl Acids. 2023 Mar; 4(1):72-89. PMID: 37859665.
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    16. Kowalski RG, Ledreux A, Violette JE, Neumann RT, Ornelas D, Yu X, Griffiths SG, Lewis S, Nash P, Monte AA, Coughlan CM, Deighan C, Grotta JC, Jones WJ, Graner MW. Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit. Stroke. 2023 03; 54(3):e52-e57. PMID: 36727508.
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    17. Araya P, Kinning KT, Coughlan C, Smith KP, Granrath RE, Enriquez-Estrada BA, Worek K, Sullivan KD, Rachubinski AL, Wolter-Warmerdam K, Hickey F, Galbraith MD, Potter H, Espinosa JM. IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome. Cell Rep. 2022 12 27; 41(13):111883. PMID: 36577365.
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    18. Zhou W, Lovasz D, Zizzo Z, He Q, Coughlan C, Kowalski RG, Kennedy PGE, Graner AN, Lillehei KO, Ormond DR, Youssef AS, Graner MW, Yu X. Phenotype and Neuronal Cytotoxic Function of Glioblastoma Extracellular Vesicles. Biomedicines. 2022 10 27; 10(11). PMID: 36359238.
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    19. Johnson NR, Wang AC, Coughlan C, Sillau S, Lucero E, Viltz L, Markham N, Allen C, Dhanasekaran AR, Chial HJ, Potter H. Imipramine and olanzapine block apoE4-catalyzed polymerization of A? and show evidence of improving Alzheimer's disease cognition. Alzheimers Res Ther. 2022 06 29; 14(1):88. PMID: 35768831.
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    20. Ng TKS, Heyn PC, Tagawa A, Coughlan C, Carollo JJ. Associations of Circulating Insulin-Growth Factor-1 With Cognitive Functions and Quality of Life Domains in Ambulatory Young Adults With Cerebral Palsy: A Pilot Study. Front Neurol. 2022; 13:748015. PMID: 35832183.
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    21. Ahmed MM, Wang AC, Elos M, Chial HJ, Sillau S, Solano DA, Coughlan C, Aghili L, Anton P, Markham N, Adame V, Gardiner KJ, Boyd TD, Potter H. The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice. Neurobiol Dis. 2022 06 15; 168:105694. PMID: 35307513.
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    22. Galvin J, Curran E, Arteaga F, Goossens A, Aubuchon-Endsley N, McMurray MA, Moore J, Hansen KC, Chial HJ, Potter H, Brodsky JL, Coughlan CM. Proteasome activity modulates amyloid toxicity. FEMS Yeast Res. 2022 03 09; 22(1). PMID: 35150241.
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    23. Rudy MJ, Coughlan C, Hixon AM, Clarke P, Tyler KL. Density Analysis of Enterovirus D68 Shows Viral Particles Can Associate with Exosomes. Microbiol Spectr. 2022 02 23; 10(1):e0245221. PMID: 35170992.
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    24. Flores-Bellver M, Mighty J, Aparicio-Domingo S, Li KV, Shi C, Zhou J, Cobb H, McGrath P, Michelis G, Lenhart P, Bilousova G, Heissel S, Rudy MJ, Coughlan C, Goodspeed AE, Becerra SP, Redenti S, Canto-Soler MV. Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors. J Extracell Vesicles. 2021 11; 10(13):e12165. PMID: 34750957.
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    25. Ng TKS, Coughlan C, Heyn PC, Tagawa A, Carollo JJ, Kua EH, Mahendran R. Increased plasma brain-derived neurotrophic factor (BDNF) as a potential biomarker for and compensatory mechanism in mild cognitive impairment: a case-control study. Aging (Albany NY). 2021 10 15; 13(19):22666-22689. PMID: 34607976.
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    26. Ahmed MM, Johnson NR, Boyd TD, Coughlan C, Chial HJ, Potter H. Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners? Front Aging Neurosci. 2021; 13:718426. PMID: 34603007.
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    27. Bubak AN, Beseler C, Como CN, Coughlan CM, Johnson NR, Hassell JE, Burnet AM, Mescher T, Schmid DS, Coleman C, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Shilleh AH, Russ HA, Nagel MA. Amylin, A?42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells. J Infect Dis. 2021 04 08; 223(7):1284-1294. PMID: 32809013.
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    28. Potter H, Woodcock JH, Boyd TD, Coughlan CM, O'Shaughnessy JR, Borges MT, Thaker AA, Raj BA, Adamszuk K, Scott D, Adame V, Anton P, Chial HJ, Gray H, Daniels J, Stocker ME, Sillau SH. Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease. Alzheimers Dement (N Y). 2021; 7(1):e12158. PMID: 33778150.
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    29. Bettcher BM, Olson KE, Carlson NE, McConnell BV, Boyd T, Adame V, Solano DA, Anton P, Markham N, Thaker AA, Jensen AM, Dallmann EN, Potter H, Coughlan C. Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease. Neurobiol Aging. 2021 07; 103:68-77. PMID: 33845398.
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    30. Coughlan C, Bruce KD, Burgy O, Boyd TD, Michel CR, Garcia-Perez JE, Adame V, Anton P, Bettcher BM, Chial HJ, K?nigshoff M, Hsieh EWY, Graner M, Potter H. Exosome Isolation by Ultracentrifugation and Precipitation and Techniques for Downstream Analyses. Curr Protoc Cell Biol. 2020 09; 88(1):e110. PMID: 32633898.
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    31. Bubak AN, Como CN, Coughlan CM, Johnson NR, Hassell JE, Mescher T, Niemeyer CS, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Russ HA, Nagel MA. Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-?, and an Amyloidogenic Extracellular Environment. J Infect Dis. 2020 03 16; 221(7):1088-1097. PMID: 31665341.
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    32. Martin-Medina A, Lehmann M, Burgy O, Hermann S, Baarsma HA, Wagner DE, De Santis MM, Ciolek F, Hofer TP, Frankenberger M, Aichler M, Lindner M, Gesierich W, Guenther A, Walch A, Coughlan C, Wolters P, Lee JS, Behr J, K?nigshoff M. Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2018 12 15; 198(12):1527-1538. PMID: 30044642.
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    33. Caneus J, Granic A, Rademakers R, Dickson DW, Coughlan CM, Chial HJ, Potter H. Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations. Mol Biol Cell. 2018 03 01; 29(5):575-586. PMID: 29282277.
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    34. Boersma I, Jones J, Coughlan C, Carter J, Bekelman D, Miyasaki J, Kutner J, Kluger B. Palliative Care and Parkinson's Disease: Caregiver Perspectives. J Palliat Med. 2017 09; 20(9):930-938. PMID: 28520498.
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    35. Aivazidis S, Coughlan CM, Rauniyar AK, Jiang H, Liggett LA, Maclean KN, Roede JR. The burden of trisomy 21 disrupts the proteostasis network in Down syndrome. PLoS One. 2017; 12(4):e0176307. PMID: 28430800.
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    36. Coughlan C, Walker DI, Lohr KM, Richardson JR, Saba LM, Caudle WM, Fritz KS, Roede JR. Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice. Parkinsons Dis. 2015; 2015:812532. PMID: 26345149.
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    37. Harris PS, Roy SR, Coughlan C, Orlicky DJ, Liang Y, Shearn CT, Roede JR, Fritz KS. Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney. Redox Biol. 2015 Dec; 6:33-40. PMID: 26177469.
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    38. Finlay-Schultz J, Canastar A, Short M, El Gazzar M, Coughlan C, Leonard S. Transcriptional repression of the a7 nicotinic acetylcholine receptor subunit gene (CHRNA7) by activating protein-2a (AP-2a). J Biol Chem. 2011 Dec 09; 286(49):42123-42132. PMID: 21979958.
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    39. Falcone D, Henderson MP, Nieuwland H, Coughlan CM, Brodsky JL, Andrews DW. Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence. Biochem J. 2011 Jun 01; 436(2):291-303. PMID: 21355855.
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    40. Sparvero LJ, Patz S, Brodsky JL, Coughlan CM. Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast. Anal Biochem. 2007 Nov 15; 370(2):162-70. PMID: 17869211.
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    41. Coughlan CM, Brodsky JL. Use of yeast as a model system to investigate protein conformational diseases. Mol Biotechnol. 2005 Jun; 30(2):171-80. PMID: 15920289.
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    42. Coughlan CM, Walker JL, Cochran JC, Wittrup KD, Brodsky JL. Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control. J Biol Chem. 2004 Apr 09; 279(15):15289-97. PMID: 14744871.
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    43. Chalasani SH, Baribaud F, Coughlan CM, Sunshine MJ, Lee VM, Doms RW, Littman DR, Raper JA. The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells. J Neurosci. 2003 Jun 01; 23(11):4601-12. PMID: 12805300.
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    44. Coughlan CM, Brodsky JL. Yeast as a model system to investigate protein conformational diseases. Methods Mol Biol. 2003; 232:77-90. PMID: 12840541.
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    45. Puffer BA, Sharron M, Coughlan CM, Baribaud F, McManus CM, Lee B, David J, Price K, Horuk R, Tsang M, Doms RW. Expression and coreceptor function of APJ for primate immunodeficiency viruses. Virology. 2000 Oct 25; 276(2):435-44. PMID: 11040134.
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    46. Coughlan CM, Breen KC. Factors influencing the processing and function of the amyloid beta precursor protein--a potential therapeutic target in Alzheimer's disease? Pharmacol Ther. 2000 May; 86(2):111-45. PMID: 10799711.
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    47. Coughlan CM, McManus CM, Sharron M, Gao Z, Murphy D, Jaffer S, Choe W, Chen W, Hesselgesser J, Gaylord H, Kalyuzhny A, Lee VM, Wolf B, Doms RW, Kolson DL. Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons. Neuroscience. 2000; 97(3):591-600. PMID: 10828541.
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    48. Budas G, Coughlan CM, Seckl JR, Breen KC. The effect of corticosteroids on amyloid beta precursor protein/amyloid precursor-like protein expression and processing in vivo. Neurosci Lett. 1999 Nov 26; 276(1):61-4. PMID: 10586975.
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    49. McFarlane I, Georgopoulou N, Coughlan CM, Gillian AM, Breen KC. The role of the protein glycosylation state in the control of cellular transport of the amyloid beta precursor protein. Neuroscience. 1999 Apr; 90(1):15-25. PMID: 10188930.
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    50. Breen KC, Coughlan CM, Hayes FD. The role of glycoproteins in neural development function, and disease. Mol Neurobiol. 1998 Apr; 16(2):163-220. PMID: 9588627.
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    51. Coughlan CM, Breen KC. Glucocorticoid induction of the alpha2,6 sialyltransferase enzyme in a mouse neural cell line. J Neurosci Res. 1998 Mar 01; 51(5):619-26. PMID: 9512006.
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    52. Maguire TM, Coughlan CM, Seckl JR, Breen KC. The effect of corticosteroids on serum sialyltransferase enzyme activities in the rat. Biochim Biophys Acta. 1998 Jan 08; 1379(1):23-8. PMID: 9468328.
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    53. Coughlan CM, Burger PG, Berger EG, Breen KC. The biochemical consequences of alpha2,6(N) sialyltransferase induction by dexamethasone on sialoglycoprotein expression in the rat H411e hepatoma cell line. FEBS Lett. 1997 Aug 18; 413(2):389-93. PMID: 9280318.
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    54. Coughlan CM, Seckl JR, Breen KC. The expression of neural cell sialoglycoproteins following glucocorticoid regulation of sialyltransferase activity in vivo. Cell Mol Neurobiol. 1996 Jun; 16(3):433-8. PMID: 8818410.
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    55. Coughlan CM, Seckl JR, Fox DJ, Unsworth R, Breen KC. Tissue-specific regulation of sialyltransferase activities in the rat by corticosteroids in vivo. Glycobiology. 1996 Jan; 6(1):15-22. PMID: 8991504.
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    56. Coughlan CM, Breen KC. The control of sialyltransferase activity in tumor-cell lines derived from different tissues in multifactorial. FEBS Lett. 1995 Aug 07; 369(2-3):260-2. PMID: 7649268.
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    57. Maguire TM, Gillian AM, O'Mahony D, Coughlan CM, Dennihan A, Breen KC. A decrease in serum sialyltransferase levels in Alzheimer's disease. Neurobiol Aging. 1994 Jan-Feb; 15(1):99-102. PMID: 8159268.
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