Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Christina Mary Coughlan

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-NEUR General Operations
Phone303/724-1348

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bubak AN, Coughlan C, Posey J, Saviola AJ, Niemeyer CS, Lewis SWR, Lopez SB, Solano A, Tyring SK, Delaney C, Neeves KB, Mahalingam R, Hansen KC, Nagel MA. Zoster-Associated Prothrombotic Plasma Exosomes and Increased Stroke Risk. J Infect Dis. 2023 Apr 18; 227(8):993-1001. PMID: 36200236.
      View in: PubMed
    2. Kowalski RG, Ledreux A, Violette JE, Neumann RT, Ornelas D, Yu X, Griffiths SG, Lewis S, Nash P, Monte AA, Coughlan CM, Deighan C, Grotta JC, Jones WJ, Graner MW. Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit. Stroke. 2023 03; 54(3):e52-e57. PMID: 36727508.
      View in: PubMed
    3. Araya P, Kinning KT, Coughlan C, Smith KP, Granrath RE, Enriquez-Estrada BA, Worek K, Sullivan KD, Rachubinski AL, Wolter-Warmerdam K, Hickey F, Galbraith MD, Potter H, Espinosa JM. IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome. Cell Rep. 2022 Dec 27; 41(13):111883. PMID: 36577365.
      View in: PubMed
    4. Zhou W, Lovasz D, Zizzo Z, He Q, Coughlan C, Kowalski RG, KennedyI PGE, Graner AN, Lillehei KO, Ormond DR, Youssef AS, Graner MW, Yu X. Phenotype and Neuronal Cytotoxic Function of Glioblastoma Extracellular Vesicles. Biomedicines. 2022 Oct 27; 10(11). PMID: 36359238.
      View in: PubMed
    5. Johnson NR, Wang AC, Coughlan C, Sillau S, Lucero E, Viltz L, Markham N, Allen C, Dhanasekaran AR, Chial HJ, Potter H. Imipramine and olanzapine block apoE4-catalyzed polymerization of A? and show evidence of improving Alzheimer's disease cognition. Alzheimers Res Ther. 2022 06 29; 14(1):88. PMID: 35768831.
      View in: PubMed
    6. Ng TKS, Heyn PC, Tagawa A, Coughlan C, Carollo JJ. Associations of Circulating Insulin-Growth Factor-1 With Cognitive Functions and Quality of Life Domains in Ambulatory Young Adults With Cerebral Palsy: A Pilot Study. Front Neurol. 2022; 13:748015. PMID: 35832183.
      View in: PubMed
    7. Ahmed MM, Wang AC, Elos M, Chial HJ, Sillau S, Solano DA, Coughlan C, Aghili L, Anton P, Markham N, Adame V, Gardiner KJ, Boyd TD, Potter H. The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice. Neurobiol Dis. 2022 06 15; 168:105694. PMID: 35307513.
      View in: PubMed
    8. Galvin J, Curran E, Arteaga F, Goossens A, Aubuchon-Endsley N, McMurray MA, Moore J, Hansen KC, Chial HJ, Potter H, Brodsky JL, Coughlan CM. Proteasome activity modulates amyloid toxicity. FEMS Yeast Res. 2022 03 09; 22(1). PMID: 35150241.
      View in: PubMed
    9. Rudy MJ, Coughlan C, Hixon AM, Clarke P, Tyler KL. Density Analysis of Enterovirus D68 Shows Viral Particles Can Associate with Exosomes. Microbiol Spectr. 2022 02 23; 10(1):e0245221. PMID: 35170992.
      View in: PubMed
    10. Flores-Bellver M, Mighty J, Aparicio-Domingo S, Li KV, Shi C, Zhou J, Cobb H, McGrath P, Michelis G, Lenhart P, Bilousova G, Heissel S, Rudy MJ, Coughlan C, Goodspeed AE, Becerra SP, Redenti S, Canto-Soler MV. Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors. J Extracell Vesicles. 2021 11; 10(13):e12165. PMID: 34750957.
      View in: PubMed
    11. Ahmed MM, Johnson NR, Boyd TD, Coughlan C, Chial HJ, Potter H. Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners? Front Aging Neurosci. 2021; 13:718426. PMID: 34603007.
      View in: PubMed
    12. Bubak AN, Beseler C, Como CN, Coughlan CM, Johnson NR, Hassell JE, Burnet AM, Mescher T, Schmid DS, Coleman C, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Shilleh AH, Russ HA, Nagel MA. Amylin, A?42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells. J Infect Dis. 2021 04 08; 223(7):1284-1294. PMID: 32809013.
      View in: PubMed
    13. Potter H, Woodcock JH, Boyd TD, Coughlan CM, O'Shaughnessy JR, Borges MT, Thaker AA, Raj BA, Adamszuk K, Scott D, Adame V, Anton P, Chial HJ, Gray H, Daniels J, Stocker ME, Sillau SH. Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease. Alzheimers Dement (N Y). 2021; 7(1):e12158. PMID: 33778150.
      View in: PubMed
    14. Bettcher BM, Olson KE, Carlson NE, McConnell BV, Boyd T, Adame V, Solano DA, Anton P, Markham N, Thaker AA, Jensen AM, Dallmann EN, Potter H, Coughlan C. Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease. Neurobiol Aging. 2021 07; 103:68-77. PMID: 33845398.
      View in: PubMed
    15. Coughlan C, Bruce KD, Burgy O, Boyd TD, Michel CR, Garcia-Perez JE, Adame V, Anton P, Bettcher BM, Chial HJ, K?nigshoff M, Hsieh EWY, Graner M, Potter H. Exosome Isolation by Ultracentrifugation and Precipitation and Techniques for Downstream Analyses. Curr Protoc Cell Biol. 2020 09; 88(1):e110. PMID: 32633898.
      View in: PubMed
    16. Bubak AN, Como CN, Coughlan CM, Johnson NR, Hassell JE, Mescher T, Niemeyer CS, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Russ HA, Nagel MA. Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-?, and an Amyloidogenic Extracellular Environment. J Infect Dis. 2020 03 16; 221(7):1088-1097. PMID: 31665341.
      View in: PubMed
    17. Caneus J, Granic A, Rademakers R, Dickson DW, Coughlan CM, Chial HJ, Potter H. Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations. Mol Biol Cell. 2018 03 01; 29(5):575-586. PMID: 29282277.
      View in: PubMed
    18. Boersma I, Jones J, Coughlan C, Carter J, Bekelman D, Miyasaki J, Kutner J, Kluger B. Palliative Care and Parkinson's Disease: Caregiver Perspectives. J Palliat Med. 2017 09; 20(9):930-938. PMID: 28520498.
      View in: PubMed
    19. Aivazidis S, Coughlan CM, Rauniyar AK, Jiang H, Liggett LA, Maclean KN, Roede JR. The burden of trisomy 21 disrupts the proteostasis network in Down syndrome. PLoS One. 2017; 12(4):e0176307. PMID: 28430800.
      View in: PubMed
    20. Coughlan C, Walker DI, Lohr KM, Richardson JR, Saba LM, Caudle WM, Fritz KS, Roede JR. Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice. Parkinsons Dis. 2015; 2015:812532. PMID: 26345149.
      View in: PubMed
    21. Harris PS, Roy SR, Coughlan C, Orlicky DJ, Liang Y, Shearn CT, Roede JR, Fritz KS. Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney. Redox Biol. 2015 Dec; 6:33-40. PMID: 26177469.
      View in: PubMed
    22. Finlay-Schultz J, Canastar A, Short M, El Gazzar M, Coughlan C, Leonard S. Transcriptional repression of the a7 nicotinic acetylcholine receptor subunit gene (CHRNA7) by activating protein-2a (AP-2a). J Biol Chem. 2011 Dec 09; 286(49):42123-42132. PMID: 21979958.
      View in: PubMed
    23. Falcone D, Henderson MP, Nieuwland H, Coughlan CM, Brodsky JL, Andrews DW. Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence. Biochem J. 2011 Jun 01; 436(2):291-303. PMID: 21355855.
      View in: PubMed
    24. Sparvero LJ, Patz S, Brodsky JL, Coughlan CM. Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast. Anal Biochem. 2007 Nov 15; 370(2):162-70. PMID: 17869211.
      View in: PubMed
    25. Coughlan CM, Brodsky JL. Use of yeast as a model system to investigate protein conformational diseases. Mol Biotechnol. 2005 Jun; 30(2):171-80. PMID: 15920289.
      View in: PubMed
    26. Coughlan CM, Walker JL, Cochran JC, Wittrup KD, Brodsky JL. Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control. J Biol Chem. 2004 Apr 09; 279(15):15289-97. PMID: 14744871.
      View in: PubMed
    27. Chalasani SH, Baribaud F, Coughlan CM, Sunshine MJ, Lee VM, Doms RW, Littman DR, Raper JA. The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells. J Neurosci. 2003 Jun 01; 23(11):4601-12. PMID: 12805300.
      View in: PubMed
    28. Coughlan CM, Brodsky JL. Yeast as a model system to investigate protein conformational diseases. Methods Mol Biol. 2003; 232:77-90. PMID: 12840541.
      View in: PubMed
    29. Puffer BA, Sharron M, Coughlan CM, Baribaud F, McManus CM, Lee B, David J, Price K, Horuk R, Tsang M, Doms RW. Expression and coreceptor function of APJ for primate immunodeficiency viruses. Virology. 2000 Oct 25; 276(2):435-44. PMID: 11040134.
      View in: PubMed
    30. Coughlan CM, Breen KC. Factors influencing the processing and function of the amyloid beta precursor protein--a potential therapeutic target in Alzheimer's disease? Pharmacol Ther. 2000 May; 86(2):111-45. PMID: 10799711.
      View in: PubMed
    31. Coughlan CM, McManus CM, Sharron M, Gao Z, Murphy D, Jaffer S, Choe W, Chen W, Hesselgesser J, Gaylord H, Kalyuzhny A, Lee VM, Wolf B, Doms RW, Kolson DL. Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons. Neuroscience. 2000; 97(3):591-600. PMID: 10828541.
      View in: PubMed
    32. Budas G, Coughlan CM, Seckl JR, Breen KC. The effect of corticosteroids on amyloid beta precursor protein/amyloid precursor-like protein expression and processing in vivo. Neurosci Lett. 1999 Nov 26; 276(1):61-4. PMID: 10586975.
      View in: PubMed
    33. McFarlane I, Georgopoulou N, Coughlan CM, Gillian AM, Breen KC. The role of the protein glycosylation state in the control of cellular transport of the amyloid beta precursor protein. Neuroscience. 1999 Apr; 90(1):15-25. PMID: 10188930.
      View in: PubMed
    34. Breen KC, Coughlan CM, Hayes FD. The role of glycoproteins in neural development function, and disease. Mol Neurobiol. 1998 Apr; 16(2):163-220. PMID: 9588627.
      View in: PubMed
    35. Coughlan CM, Breen KC. Glucocorticoid induction of the alpha2,6 sialyltransferase enzyme in a mouse neural cell line. J Neurosci Res. 1998 Mar 01; 51(5):619-26. PMID: 9512006.
      View in: PubMed
    36. Maguire TM, Coughlan CM, Seckl JR, Breen KC. The effect of corticosteroids on serum sialyltransferase enzyme activities in the rat. Biochim Biophys Acta. 1998 Jan 08; 1379(1):23-8. PMID: 9468328.
      View in: PubMed
    37. Coughlan CM, Burger PG, Berger EG, Breen KC. The biochemical consequences of alpha2,6(N) sialyltransferase induction by dexamethasone on sialoglycoprotein expression in the rat H411e hepatoma cell line. FEBS Lett. 1997 Aug 18; 413(2):389-93. PMID: 9280318.
      View in: PubMed
    38. Coughlan CM, Seckl JR, Breen KC. The expression of neural cell sialoglycoproteins following glucocorticoid regulation of sialyltransferase activity in vivo. Cell Mol Neurobiol. 1996 Jun; 16(3):433-8. PMID: 8818410.
      View in: PubMed
    39. Coughlan CM, Seckl JR, Fox DJ, Unsworth R, Breen KC. Tissue-specific regulation of sialyltransferase activities in the rat by corticosteroids in vivo. Glycobiology. 1996 Jan; 6(1):15-22. PMID: 8991504.
      View in: PubMed
    40. Coughlan CM, Breen KC. The control of sialyltransferase activity in tumor-cell lines derived from different tissues in multifactorial. FEBS Lett. 1995 Aug 07; 369(2-3):260-2. PMID: 7649268.
      View in: PubMed
    41. Maguire TM, Gillian AM, O'Mahony D, Coughlan CM, Dennihan A, Breen KC. A decrease in serum sialyltransferase levels in Alzheimer's disease. Neurobiol Aging. 1994 Jan-Feb; 15(1):99-102. PMID: 8159268.
      View in: PubMed
    Coughlan's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (275) concept(s)
    _
    Co-Authors Expand Description
    See all (51) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2023 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)