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Catherine Anne Proenza

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM - Physiology

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    Colorado State University, Fort Collins, COPhD1999Physiology

    Collapse Overview 
    Collapse overview
    The central goal of my research program is to understand the molecular basis of pacemaking in the sinoatrial node of the heart. Projects irange from ion channel biophysics to whole animal physiology. Information about the molecular mechanisms that govern cardiac pacemaking is critical for the development of novel and specific therapies to control heart rate. My group has extensive experience in patch clamp recordings from isolated sinoatrial node myocytes, transfected cell lines and iPSC-derived cardiomyocytes. We have also pioneered other methods for study of the sinoatrial node, including ECG recordings from unanesthetized mice, biochemistry using mouse sinoatrial node samples, immunocytochemistry, and computational approaches.

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    R01HL088427     (PROENZA, CATHERINE)Apr 1, 2007 - Mar 31, 2020
    Function and Regulation of HCN Channels in Sinoatrial Myocytes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H. Mammalian ?2 AMPK regulates intrinsic heart rate. Nat Commun. 2017 11 02; 8(1):1258. PMID: 29097735.
      View in: PubMed
    2. Rickert C, Proenza C. ParamAP: Standardized Parameterization of Sinoatrial Node Myocyte Action Potentials. Biophys J. 2017 Aug 22; 113(4):765-769. PMID: 28834713.
      View in: PubMed
    3. St Clair JR, Larson ED, Sharpe EJ, Liao Z, Proenza C. Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node Myocytes. J Cardiovasc Dev Dis. 2017 Sep; 4(3). PMID: 28868308.
      View in: PubMed
    4. Sharpe EJ, Larson ED, Proenza C. Cyclic AMP reverses the effects of aging on pacemaker activity and If in sinoatrial node myocytes. J Gen Physiol. 2017 Feb; 149(2):237-247. PMID: 28057842.
      View in: PubMed
    5. Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 04 01; 595(7):2209-2228. PMID: 27861921.
      View in: PubMed
    6. Sharpe EJ, St Clair JR, Proenza C. Methods for the Isolation, Culture, and Functional Characterization of Sinoatrial Node Myocytes from Adult Mice. J Vis Exp. 2016 10 23; (116). PMID: 27805586.
      View in: PubMed
    7. Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O'Rourke R, Jones KL, Jeong MY, Walker LA, Buttrick PM, McKinsey TA, Song K. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015 Sep 10; 6:8243. PMID: 26354680; PMCID: PMC4579788.
    8. St Clair JR, Sharpe EJ, Proenza C. Culture and adenoviral infection of sinoatrial node myocytes from adult mice. Am J Physiol Heart Circ Physiol. 2015 Aug 01; 309(3):H490-8. PMID: 26001410; PMCID: PMC4525092.
    9. Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. PLoS One. 2013; 8(11):e81633. PMID: 24278453; PMCID: PMC3836769.
    10. Larson ED, St Clair JR, Sumner WA, Bannister RA, Proenza C. Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):18011-6. PMID: 24128759; PMCID: PMC3816448.
    11. St Clair JR, Liao Z, Larson ED, Proenza C. PKA-independent activation of I(f) by cAMP in mouse sinoatrial myocytes. Channels (Austin). 2013 Jul-Aug; 7(4):318-21. PMID: 23756695; PMCID: PMC3989360.
    12. Liao Z, Lockhead D, St Clair JR, Larson ED, Wilson CE, Proenza C. Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: ligand-independent relief of autoinhibition in HCN4. J Gen Physiol. 2012 Nov; 140(5):557-66. PMID: 23109717; PMCID: PMC3483121.
    13. Liao Z, St Clair JR, Larson ED, Proenza C. Myristoylated peptides potentiate the funny current (I(f)) in sinoatrial myocytes. Channels (Austin). 2011 Mar-Apr; 5(2):115-9. PMID: 21150293; PMCID: PMC3127052.
    14. Liao Z, Lockhead D, Larson ED, Proenza C. Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node. J Gen Physiol. 2010 Sep; 136(3):247-58. PMID: 20713547; PMCID: PMC2931151.
    15. Proenza C, Yellen G. Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents. J Gen Physiol. 2006 Feb; 127(2):183-90. PMID: 16446506; PMCID: PMC2151495.
    16. Shin KS, Maertens C, Proenza C, Rothberg BS, Yellen G. Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage. Neuron. 2004 Mar 04; 41(5):737-44. PMID: 15003173.
      View in: PubMed
    17. Tran N, Proenza C, Macri V, Petigara F, Sloan E, Samler S, Accili EA. A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channels. J Biol Chem. 2002 Nov 15; 277(46):43588-92. PMID: 12193608.
      View in: PubMed
    18. Macri V, Proenza C, Agranovich E, Angoli D, Accili EA. Separable gating mechanisms in a Mammalian pacemaker channel. J Biol Chem. 2002 Sep 27; 277(39):35939-46. PMID: 12121985.
      View in: PubMed
    19. Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA. Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels. J Biol Chem. 2002 Aug 16; 277(33):29634-42. PMID: 12034718.
      View in: PubMed
    20. Accili EA, Proenza C, Baruscotti M, DiFrancesco D. From funny current to HCN channels: 20 years of excitation. News Physiol Sci. 2002 Feb; 17:32-7. PMID: 11821534.
      View in: PubMed
    21. Proenza C, Angoli D, Agranovich E, Macri V, Accili EA. Pacemaker channels produce an instantaneous current. J Biol Chem. 2002 Feb 15; 277(7):5101-9. PMID: 11741901.
      View in: PubMed
    22. Proenza C, O'Brien J, Nakai J, Mukherjee S, Allen PD, Beam KG. Identification of a region of RyR1 that participates in allosteric coupling with the alpha(1S) (Ca(V)1.1) II-III loop. J Biol Chem. 2002 Feb 22; 277(8):6530-5. PMID: 11726651.
      View in: PubMed
    23. Stroffekova K, Proenza C, Beam KG. The protein-labeling reagent FLASH-EDT2 binds not only to CCXXCC motifs but also non-specifically to endogenous cysteine-rich proteins. Pflugers Arch. 2001 Sep; 442(6):859-66. PMID: 11680618.
      View in: PubMed
    24. Proenza C, Wilkens CM, Beam KG. Excitation-contraction coupling is not affected by scrambled sequence in residues 681-690 of the dihydropyridine receptor II-III loop. J Biol Chem. 2000 Sep 29; 275(39):29935-7. PMID: 10915779.
      View in: PubMed
    25. Proenza C, Wilkens C, Lorenzon NM, Beam KG. A carboxyl-terminal region important for the expression and targeting of the skeletal muscle dihydropyridine receptor. J Biol Chem. 2000 Jul 28; 275(30):23169-74. PMID: 10801875.
      View in: PubMed
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