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Christopher Lowry

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentIntegrative Physiology
Phone303/492-6029
ORCID ORCID Icon0000-0003-3920-5575 Additional info

    Collapse Research 
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    F31MH010288     (LOWRY, CHRISTOPHER ALAN)Mar 25, 1993
    NIH/NIMH
    NEURAL MECHANISMS OF CORTICOTROPIN-RELEASING FACTOR
    Role: Principal Investigator

    R01MH065702     (SHEKHAR, ANANTHA)Mar 1, 2002 - Jun 30, 2014
    NIH/NIMH
    Role of Serotonin and CRF Pathways in Anxiety and HPA Regulations
    Role: Co-Principal Investigator

    R01MH086539     (LOWRY, CHRISTOPHER A)Sep 8, 2009 - Jun 30, 2013
    NIH/NIMH
    Mechanisms Underlying Stress-Induced Activation of Serotonergic Systems
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hale MW, Lukkes JL, Dady KF, Kelly KJ, Paul ED, Smith DG, Raison CL, Lowry CA. Whole-body hyperthermia and a subthreshold dose of citalopram act synergistically to induce antidepressant-like behavioral responses in adolescent rats. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 12; 79(Pt B):162-168. PMID: 28619470.
      View in: PubMed
    2. Brenner LA, Stearns-Yoder KA, Hoffberg AS, Penzenik ME, Starosta AJ, Hernández TD, Hadidi DA, Lowry CA. Growing literature but limited evidence: A systematic review regarding prebiotic and probiotic interventions for those with traumatic brain injury and/or posttraumatic stress disorder. Brain Behav Immun. 2017 Jun 09. PMID: 28606462.
      View in: PubMed
    3. Stamper CE, Hassell JE, Kapitz AJ, Renner KJ, Orchinik M, Lowry CA. Activation of 5-HT1A receptors in the rat dorsomedial hypothalamus inhibits stress-induced activation of the hypothalamic-pituitary-adrenal axis. Stress. 2017 Mar; 20(2):223-230. PMID: 28345385.
      View in: PubMed
    4. Raheja UK, Fuchs D, Lowry CA, Stephens SH, Pavlovich MA, Mohyuddin H, Yousufi H, Ryan KA, O'Connell J, Brenner LA, Punzalan C, Hoisington AJ, Nijjar GK, Groer M, Shuldiner AR, Pollin TI, Stiller JW, Mitchell BD, Postolache TT. Heritability of plasma neopterin levels in the Old Order Amish. J Neuroimmunol. 2017 Jun 15; 307:37-41. PMID: 28495136.
      View in: PubMed
    5. Yamashita PS, Spiacci A, Hassel JE, Lowry CA, Zangrossi H. Disinhibition of the rat prelimbic cortex promotes serotonergic activation of the dorsal raphe nucleus and panicolytic-like behavioral effects. J Psychopharmacol. 2017 Jun; 31(6):704-714. PMID: 28071216.
      View in: PubMed
    6. Langgartner D, Peterlik D, Foertsch S, Füchsl AM, Brokmann P, Flor PJ, Shen Z, Fox JG, Uschold-Schmidt N, Lowry CA, Reber SO. Individual differences in stress vulnerability: The role of gut pathobionts in stress-induced colitis. Brain Behav Immun. 2017 Aug; 64:23-32. PMID: 28012830.
      View in: PubMed
    7. Raison CL, Janssen CW, Lowry CA. Hyperthermia for Major Depressive Disorder?-Reply. JAMA Psychiatry. 2016 Oct 01; 73(10):1096-1097. PMID: 27627698.
      View in: PubMed
    8. Reber SO, Langgartner D, Foertsch S, Postolache TT, Brenner LA, Guendel H, Lowry CA. Chronic subordinate colony housing paradigm: A mouse model for mechanisms of PTSD vulnerability, targeted prevention, and treatment-2016 Curt Richter Award Paper. Psychoneuroendocrinology. 2016 Dec; 74:221-230. PMID: 27676359.
      View in: PubMed
    9. Stamper CE, Hoisington AJ, Gomez OM, Halweg-Edwards AL, Smith DG, Bates KL, Kinney KA, Postolache TT, Brenner LA, Rook GA, Lowry CA. The Microbiome of the Built Environment and Human Behavior: Implications for Emotional Health and Well-Being in Postmodern Western Societies. Int Rev Neurobiol. 2016; 131:289-323. PMID: 27793224.
      View in: PubMed
    10. Lowry CA, Smith DG, Siebler PH, Schmidt D, Stamper CE, Hassell JE, Yamashita PS, Fox JH, Reber SO, Brenner LA, Hoisington AJ, Postolache TT, Kinney KA, Marciani D, Hernandez M, Hemmings SM, Malan-Muller S, Wright KP, Knight R, Raison CL, Rook GA. The Microbiota, Immunoregulation, and Mental Health: Implications for Public Health. Curr Environ Health Rep. 2016 Sep; 3(3):270-86. PMID: 27436048.
      View in: PubMed
    11. Mathai AJ, Kanwar J, Okusaga O, Fuchs D, Lowry CA, Peng X, Giegling I, Hartmann AM, Konte B, Friedl M, Gragnoli C, Reeves GM, Groer MW, Rosenthal RN, Rujescu D, Postolache TT. Blood Levels of Monoamine Precursors and Smoking in Patients with Schizophrenia. Front Public Health. 2016; 4:182. PMID: 27626030; PMCID: PMC5003942.
    12. Janssen CW, Lowry CA, Mehl MR, Allen JJ, Kelly KL, Gartner DE, Medrano A, Begay TK, Rentscher K, White JJ, Fridman A, Roberts LJ, Robbins ML, Hanusch KU, Cole SP, Raison CL. Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2016 Aug 01; 73(8):789-95. PMID: 27172277.
      View in: PubMed
    13. Reber SO, Siebler PH, Donner NC, Morton JT, Smith DG, Kopelman JM, Lowe KR, Wheeler KJ, Fox JH, Hassell JE, Greenwood BN, Jansch C, Lechner A, Schmidt D, Uschold-Schmidt N, Füchsl AM, Langgartner D, Walker FR, Hale MW, Lopez Perez G, Van Treuren W, González A, Halweg-Edwards AL, Fleshner M, Raison CL, Rook GA, Peddada SD, Knight R, Lowry CA. Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):E3130-9. PMID: 27185913; PMCID: PMC4896712.
    14. Chiappelli J, Postolache TT, Kochunov P, Rowland LM, Wijtenburg SA, Shukla DK, Tagamets M, Du X, Savransky A, Lowry CA, Can A, Fuchs D, Hong LE. Tryptophan Metabolism and White Matter Integrity in Schizophrenia. Neuropsychopharmacology. 2016 Sep; 41(10):2587-95. PMID: 27143602; PMCID: PMC4987857 [Available on 09/01/17].
    15. Hoisington AJ, Brenner LA, Kinney KA, Postolache TT, Lowry CA. The microbiome of the built environment and mental health. Microbiome. 2015 Dec 17; 3:60. PMID: 26674771; PMCID: PMC4682225.
    16. Johnson PL, Molosh A, Fitz SD, Arendt D, Deehan GA, Federici LM, Bernabe C, Engleman EA, Rodd ZA, Lowry CA, Shekhar A. Pharmacological depletion of serotonin in the basolateral amygdala complex reduces anxiety and disrupts fear conditioning. Pharmacol Biochem Behav. 2015 Nov; 138:174-9. PMID: 26476009; PMCID: PMC4631224 [Available on 11/01/16].
    17. Okusaga O, Duncan E, Langenberg P, Brundin L, Fuchs D, Groer MW, Giegling I, Stearns-Yoder KA, Hartmann AM, Konte B, Friedl M, Brenner LA, Lowry CA, Rujescu D, Postolache TT. Combined Toxoplasma gondii seropositivity and high blood kynurenine--Linked with nonfatal suicidal self-directed violence in patients with schizophrenia. J Psychiatr Res. 2016 Jan; 72:74-81. PMID: 26594873.
      View in: PubMed
    18. Donner NC, Siebler PH, Johnson DT, Villarreal MD, Mani S, Matti AJ, Lowry CA. Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Psychoneuroendocrinology. 2016 Jan; 63:178-90. PMID: 26454419; PMCID: PMC4695240 [Available on 01/01/17].
    19. Lawther AJ, Clissold ML, Ma S, Kent S, Lowry CA, Gundlach AL, Hale MW. Anxiogenic drug administration and elevated plus-maze exposure in rats activate populations of relaxin-3 neurons in the nucleus incertus and serotonergic neurons in the dorsal raphe nucleus. Neuroscience. 2015 Sep 10; 303:270-84. PMID: 26141847.
      View in: PubMed
    20. Stamper CE, Hennessey PA, Hale MW, Lukkes JL, Donner NC, Lowe KR, Paul ED, Spencer RL, Renner KJ, Orchinik M, Lowry CA. Role of the dorsomedial hypothalamus in glucocorticoid-mediated feedback inhibition of the hypothalamic-pituitary-adrenal axis. Stress. 2015 Jan; 18(1):76-87. PMID: 25556980; PMCID: PMC4367871.
    21. Raison CL, Hale MW, Williams LE, Wager TD, Lowry CA. Somatic influences on subjective well-being and affective disorders: the convergence of thermosensory and central serotonergic systems. Front Psychol. 2014; 5:1580. PMID: 25628593; PMCID: PMC4292224.
    22. Barrientos RM, Thompson VM, Kitt MM, Amat J, Hale MW, Frank MG, Crysdale NY, Stamper CE, Hennessey PA, Watkins LR, Spencer RL, Lowry CA, Maier SF. Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. Neurobiol Aging. 2015 Mar; 36(3):1483-95. PMID: 25559333; PMCID: PMC4346455.
    23. Volk N, Paul ED, Haramati S, Eitan C, Fields BK, Zwang R, Gil S, Lowry CA, Chen A. MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1. J Neurosci. 2014 Nov 05; 34(45):15070-82. PMID: 25378171.
      View in: PubMed
    24. Brooks LR, Pals HL, Enix CL, Woolaver RA, Paul ED, Lowry CA, Tsai PS. Fibroblast growth factor 8 deficiency compromises the functional response of the serotonergic system to stress. PLoS One. 2014; 9(7):e101420. PMID: 24992493; PMCID: PMC4081718.
    25. Rook GA, Raison CL, Lowry CA. Microbial 'old friends', immunoregulation and socioeconomic status. Clin Exp Immunol. 2014 Jul; 177(1):1-12. PMID: 24401109; PMCID: PMC4089149.
    26. Issler O, Haramati S, Paul ED, Maeno H, Navon I, Zwang R, Gil S, Mayberg HS, Dunlop BW, Menke A, Awatramani R, Binder EB, Deneris ES, Lowry CA, Chen A. MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity. Neuron. 2014 Jul 16; 83(2):344-60. PMID: 24952960.
      View in: PubMed
    27. Rook GA, Lowry CA, Raison CL. Hygiene and other early childhood influences on the subsequent function of the immune system. Brain Res. 2015 Aug 18; 1617:47-62. PMID: 24732404.
      View in: PubMed
    28. Paul ED, Johnson PL, Shekhar A, Lowry CA. The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic. Neurosci Biobehav Rev. 2014 Oct; 46 Pt 3:379-96. PMID: 24661986; PMCID: PMC4170046.
    29. Brooks LR, Enix CL, Rich SC, Magno JA, Lowry CA, Tsai PS. Fibroblast growth factor deficiencies impact anxiety-like behavior and the serotonergic system. Behav Brain Res. 2014 May 01; 264:74-81. PMID: 24512770; PMCID: PMC4007771.
    30. Issler O, Carter RN, Paul ED, Kelly PA, Olverman HJ, Neufeld-Cohen A, Kuperman Y, Lowry CA, Seckl JR, Chen A, Jamieson PM. Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas. Biol Mood Anxiety Disord. 2014 Jan 21; 4(1):1. PMID: 24447313; PMCID: PMC4029322.
    31. Rook GA, Raison CL, Lowry CA. Microbiota, immunoregulatory old friends and psychiatric disorders. Adv Exp Med Biol. 2014; 817:319-56. PMID: 24997041.
      View in: PubMed
    32. Fox JH, Lowry CA. Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior. Front Neurosci. 2013 Sep 20; 7:169. PMID: 24065880; PMCID: PMC3778254.
    33. Drugan RC, Hibl PT, Kelly KJ, Dady KF, Hale MW, Lowry CA. Prior cold water swim stress alters immobility in the forced swim test and associated activation of serotonergic neurons in the rat dorsal raphe nucleus. Neuroscience. 2013 Dec 03; 253:221-34. PMID: 23999122; PMCID: PMC3845803.
    34. Hanusch KU, Janssen CH, Billheimer D, Jenkins I, Spurgeon E, Lowry CA, Raison CL. Whole-body hyperthermia for the treatment of major depression: associations with thermoregulatory cooling. Am J Psychiatry. 2013 Jul; 170(7):802-4. PMID: 23820835.
      View in: PubMed
    35. Paul ED, Lowry CA. Functional topography of serotonergic systems supports the Deakin/Graeff hypothesis of anxiety and affective disorders. J Psychopharmacol. 2013 Dec; 27(12):1090-106. PMID: 23704363.
      View in: PubMed
    36. Donner NC, Lowry CA. Sex differences in anxiety and emotional behavior. Pflugers Arch. 2013 May; 465(5):601-26. PMID: 23588380; PMCID: PMC3805826.
    37. Rook GA, Lowry CA, Raison CL. Microbial 'Old Friends', immunoregulation and stress resilience. Evol Med Public Health. 2013 Jan; 2013(1):46-64. PMID: 24481186; PMCID: PMC3868387.
    38. Johnson PL, Sajdyk TJ, Fitz SD, Hale MW, Lowry CA, Hay-Schmidt A, Shekhar A. Angiotensin II's role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: amygdalar angiotensin receptors and panic. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 01; 44:248-56. PMID: 23523745; PMCID: PMC3665353.
    39. Lukkes JL, Kopelman JM, Donner NC, Hale MW, Lowry CA. Development × environment interactions control tph2 mRNA expression. Neuroscience. 2013 May 01; 237:139-50. PMID: 23403177; PMCID: PMC4900171.
    40. Rook GA, Raison CL, Lowry CA. Childhood microbial experience, immunoregulation, inflammation and adult susceptibility to psychosocial stressors and depression in rich and poor countries. Evol Med Public Health. 2013 Jan; 2013(1):14-7. PMID: 24481181; PMCID: PMC4183960.
    41. Barr JL, Scholl JL, Solanki RR, Watt MJ, Lowry CA, Renner KJ, Forster GL. Influence of chronic amphetamine treatment and acute withdrawal on serotonin synthesis and clearance mechanisms in the rat ventral hippocampus. Eur J Neurosci. 2013 Feb; 37(3):479-90. PMID: 23157166; PMCID: PMC3563776.
    42. Hale MW, Raison CL, Lowry CA. Integrative physiology of depression and antidepressant drug action: implications for serotonergic mechanisms of action and novel therapeutic strategies for treatment of depression. Pharmacol Ther. 2013 Jan; 137(1):108-18. PMID: 23017938.
      View in: PubMed
    43. Jasinska AJ, Lowry CA, Burmeister M. Corrigendum: Serotonin transporter gene, stress, and raphe–raphe interactions: a molecular mechanism of depression. Trends Neurosci. 2012 Jul; 35(7):454-5. PMID: 22919705.
      View in: PubMed
    44. Hale MW, Rook GA, Lowry CA. Pathways underlying afferent signaling of bronchopulmonary immune activation to the central nervous system. Chem Immunol Allergy. 2012; 98:118-41. PMID: 22767061.
      View in: PubMed
    45. Neufeld-Cohen A, Kelly PA, Paul ED, Carter RN, Skinner E, Olverman HJ, Vaughan JM, Issler O, Kuperman Y, Lowry CA, Vale WW, Seckl JR, Chen A, Jamieson PM. Chronic activation of corticotropin-releasing factor type 2 receptors reveals a key role for 5-HT1A receptor responsiveness in mediating behavioral and serotonergic responses to stressful challenge. Biol Psychiatry. 2012 Sep 15; 72(6):437-47. PMID: 22704666; PMCID: PMC3430862.
    46. Lukkes JL, Burke AR, Zelin NS, Hale MW, Lowry CA. Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats. Physiol Behav. 2012 Dec 05; 107(5):719-25. PMID: 22583860; PMCID: PMC3466367.
    47. Johnson PL, Samuels BC, Fitz SD, Federici LM, Hammes N, Early MC, Truitt W, Lowry CA, Shekhar A. Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Physiol Behav. 2012 Dec 05; 107(5):733-42. PMID: 22554617; PMCID: PMC3472124.
    48. Wright KP, Lowry CA, Lebourgeois MK. Circadian and wakefulness-sleep modulation of cognition in humans. Front Mol Neurosci. 2012; 5:50. PMID: 22529774; PMCID: PMC3328852.
    49. Hale MW, Shekhar A, Lowry CA. Stress-related serotonergic systems: implications for symptomatology of anxiety and affective disorders. Cell Mol Neurobiol. 2012 Jul; 32(5):695-708. PMID: 22484834; PMCID: PMC3378822.
    50. Rook GA, Raison CL, Lowry CA. Can we vaccinate against depression? Drug Discov Today. 2012 May; 17(9-10):451-8. PMID: 22507593.
      View in: PubMed
    51. Donner NC, Johnson PL, Fitz SD, Kellen KE, Shekhar A, Lowry CA. Elevated tph2 mRNA expression in a rat model of chronic anxiety. Depress Anxiety. 2012 Apr; 29(4):307-19. PMID: 22511363; PMCID: PMC4414333.
    52. Johnson PL, Samuels BC, Fitz SD, Lightman SL, Lowry CA, Shekhar A. Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia. Neuropsychopharmacology. 2012 Jul; 37(8):1911-22. PMID: 22453138; PMCID: PMC3376323.
    53. Jasinska AJ, Lowry CA, Burmeister M. Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression. Trends Neurosci. 2012 Jul; 35(7):395-402. PMID: 22301434.
      View in: PubMed
    54. Lukkes JL, Engelman GH, Zelin NS, Hale MW, Lowry CA. Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems. Brain Res. 2012 Mar 14; 1443:1-17. PMID: 22297173; PMCID: PMC3294258.
    55. Rozeske RR, Evans AK, Frank MG, Watkins LR, Lowry CA, Maier SF. Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus. J Neurosci. 2011 Oct 05; 31(40):14107-15. PMID: 21976495; PMCID: PMC3207271.
    56. Kelly KJ, Donner NC, Hale MW, Lowry CA. Swim stress activates serotonergic and nonserotonergic neurons in specific subdivisions of the rat dorsal raphe nucleus in a temperature-dependent manner. Neuroscience. 2011 Dec 01; 197:251-68. PMID: 21945646; PMCID: PMC3219528.
    57. Donner NC, Montoya CD, Lukkes JL, Lowry CA. Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression. Psychoneuroendocrinology. 2012 May; 37(5):645-61. PMID: 21924839; PMCID: PMC3249349.
    58. Hale MW, Shekhar A, Lowry CA. Development by environment interactions controlling tryptophan hydroxylase expression. J Chem Neuroanat. 2011 Jul; 41(4):219-26. PMID: 21640184; PMCID: PMC3350375.
    59. Lukkes JL, Staub DR, Dietrich A, Truitt W, Neufeld-Cohen A, Chen A, Johnson PL, Shekhar A, Lowry CA. Topographical distribution of corticotropin-releasing factor type 2 receptor-like immunoreactivity in the rat dorsal raphe nucleus: co-localization with tryptophan hydroxylase. Neuroscience. 2011 Jun 02; 183:47-63. PMID: 21453754; PMCID: PMC3092641.
    60. Spannuth BM, Hale MW, Evans AK, Lukkes JL, Campeau S, Lowry CA. Investigation of a central nucleus of the amygdala/dorsal raphe nucleus serotonergic circuit implicated in fear-potentiated startle. Neuroscience. 2011 Apr 14; 179:104-19. PMID: 21277950; PMCID: PMC3059387.
    61. Paul ED, Hale MW, Lukkes JL, Valentine MJ, Sarchet DM, Lowry CA. Repeated social defeat increases reactive emotional coping behavior and alters functional responses in serotonergic neurons in the rat dorsal raphe nucleus. Physiol Behav. 2011 Aug 03; 104(2):272-82. PMID: 21238469; PMCID: PMC3089807.
    62. Rook GA, Lowry CA, Raison CL. Lymphocytes in neuroprotection, cognition and emotion: is intolerance really the answer? Brain Behav Immun. 2011 May; 25(4):591-601. PMID: 21167931.
      View in: PubMed
    63. Raison CL, Lowry CA, Rook GA. Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression. Arch Gen Psychiatry. 2010 Dec; 67(12):1211-24. PMID: 21135322; PMCID: PMC3724429.
    64. Hale MW, Dady KF, Evans AK, Lowry CA. Evidence for in vivo thermosensitivity of serotonergic neurons in the rat dorsal raphe nucleus and raphe pallidus nucleus implicated in thermoregulatory cooling. Exp Neurol. 2011 Feb; 227(2):264-78. PMID: 21111735.
      View in: PubMed
    65. Hale MW, Lowry CA. Functional topography of midbrain and pontine serotonergic systems: implications for synaptic regulation of serotonergic circuits. Psychopharmacology (Berl). 2011 Feb; 213(2-3):243-64. PMID: 21088958.
      View in: PubMed
    66. Neufeld-Cohen A, Tsoory MM, Evans AK, Getselter D, Gil S, Lowry CA, Vale WW, Chen A. A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):19020-5. PMID: 20937857; PMCID: PMC2973872.
    67. Hale MW, Johnson PL, Westerman AM, Abrams JK, Shekhar A, Lowry CA. Multiple anxiogenic drugs recruit a parvalbumin-containing subpopulation of GABAergic interneurons in the basolateral amygdala. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Oct 01; 34(7):1285-93. PMID: 20647026; PMCID: PMC2940267.
    68. Hale MW, Stamper CE, Staub DR, Lowry CA. Urocortin 2 increases c-Fos expression in serotonergic neurons projecting to the ventricular/periventricular system. Exp Neurol. 2010 Jul; 224(1):271-81. PMID: 20382145; PMCID: PMC2885541.
    69. Feng N, Lowry CA, Lukkes JL, Orchinik M, Forster GL, Renner KJ. Organic cation transporter inhibition increases medial hypothalamic serotonin under basal conditions and during mild restraint. Brain Res. 2010 Apr 22; 1326:105-13. PMID: 20171957; PMCID: PMC2852317.
    70. Johnson PL, Fitz SD, Hollis JH, Moratalla R, Lightman SL, Shekhar A, Lowry CA. Induction of c-Fos in 'panic/defence'-related brain circuits following brief hypercarbic gas exposure. J Psychopharmacol. 2011 Jan; 25(1):26-36. PMID: 20080924.
      View in: PubMed
    71. Neufeld-Cohen A, Evans AK, Getselter D, Spyroglou A, Hill A, Gil S, Tsoory M, Beuschlein F, Lowry CA, Vale W, Chen A. Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits. Mol Psychiatry. 2010 Apr; 15(4):426-41, 339. PMID: 19884890.
      View in: PubMed
    72. Gardner KL, Hale MW, Lightman SL, Plotsky PM, Lowry CA. Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression. Brain Res. 2009 Dec 11; 1305:47-63. PMID: 19781533; PMCID: PMC2788613.
    73. Lukkes JL, Watt MJ, Lowry CA, Forster GL. Consequences of post-weaning social isolation on anxiety behavior and related neural circuits in rodents. Front Behav Neurosci. 2009; 3:18. PMID: 19738931; PMCID: PMC2737489.
    74. Gardner KL, Hale MW, Oldfield S, Lightman SL, Plotsky PM, Lowry CA. Adverse experience during early life and adulthood interact to elevate tph2 mRNA expression in serotonergic neurons within the dorsal raphe nucleus. Neuroscience. 2009 Nov 10; 163(4):991-1001. PMID: 19647049; PMCID: PMC2760611.
    75. Lowry CA, Hale MW, Burke KA, Renner KJ, Moore FL. Fluoxetine potentiates the effects of corticotropin-releasing factor on locomotor activity and serotonergic systems in the roughskin newt, Taricha granulosa. Horm Behav. 2009 Jun; 56(1):177-84. PMID: 19409390.
      View in: PubMed
    76. Lowry CA, Hale MW, Plant A, Windle RJ, Shanks N, Wood SA, Ingram CD, Renner KJ, Lightman SL, Summers CH. Fluoxetine inhibits corticotropin-releasing factor (CRF)-induced behavioural responses in rats. Stress. 2009 May; 12(3):225-39. PMID: 18951247.
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    77. Feng N, Telefont M, Kelly KJ, Orchinik M, Forster GL, Renner KJ, Lowry CA. Local perfusion of corticosterone in the rat medial hypothalamus potentiates D-fenfluramine-induced elevations of extracellular 5-HT concentrations. Horm Behav. 2009 Jun; 56(1):149-57. PMID: 19371745.
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    78. Evans AK, Heerkens JL, Lowry CA. Acoustic stimulation in vivo and corticotropin-releasing factor in vitro increase tryptophan hydroxylase activity in the rat caudal dorsal raphe nucleus. Neurosci Lett. 2009 May 08; 455(1):36-41. PMID: 19429102.
      View in: PubMed
    79. Gasser PJ, Orchinik M, Raju I, Lowry CA. Distribution of organic cation transporter 3, a corticosterone-sensitive monoamine transporter, in the rat brain. J Comp Neurol. 2009 Feb 01; 512(4):529-55. PMID: 19025979.
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    80. Lowry CA, Lightman SL, Nutt DJ. That warm fuzzy feeling: brain serotonergic neurons and the regulation of emotion. J Psychopharmacol. 2009 Jun; 23(4):392-400. PMID: 19074539.
      View in: PubMed
    81. Lowry CA, Hale MW, Evans AK, Heerkens J, Staub DR, Gasser PJ, Shekhar A. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Ann N Y Acad Sci. 2008 Dec; 1148:86-94. PMID: 19120094.
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    82. Hale MW, Hay-Schmidt A, Mikkelsen JD, Poulsen B, Bouwknecht JA, Evans AK, Stamper CE, Shekhar A, Lowry CA. Exposure to an open-field arena increases c-Fos expression in a subpopulation of neurons in the dorsal raphe nucleus, including neurons projecting to the basolateral amygdaloid complex. Neuroscience. 2008 Dec 10; 157(4):733-48. PMID: 18951955; PMCID: PMC3072241.
    83. Forster GL, Pringle RB, Mouw NJ, Vuong SM, Watt MJ, Burke AR, Lowry CA, Summers CH, Renner KJ. Corticotropin-releasing factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activity. Eur J Neurosci. 2008 Jul; 28(2):299-310. PMID: 18702701.
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    84. Hale MW, Hay-Schmidt A, Mikkelsen JD, Poulsen B, Shekhar A, Lowry CA. Exposure to an open-field arena increases c-Fos expression in a distributed anxiety-related system projecting to the basolateral amygdaloid complex. Neuroscience. 2008 Aug 26; 155(3):659-72. PMID: 18616985; PMCID: PMC2637823.
    85. Evans AK, Reinders N, Ashford KA, Christie IN, Wakerley JB, Lowry CA. Evidence for serotonin synthesis-dependent regulation of in vitro neuronal firing rates in the midbrain raphe complex. Eur J Pharmacol. 2008 Aug 20; 590(1-3):136-49. PMID: 18577382.
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    86. Rook GA, Lowry CA. The hygiene hypothesis and psychiatric disorders. Trends Immunol. 2008 Apr; 29(4):150-8. PMID: 18328783.
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    87. Johnson PL, Truitt WA, Fitz SD, Lowry CA, Shekhar A. Neural pathways underlying lactate-induced panic. Neuropsychopharmacology. 2008 Aug; 33(9):2093-107. PMID: 18059441; PMCID: PMC3065200.
    88. Davies SJ, Lowry CA, Nutt DJ. Panic and hypertension: brothers in arms through 5-HT? J Psychopharmacol. 2007 Aug; 21(6):563-6. PMID: 17901092.
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    89. Lowry CA, Hollis JH, de Vries A, Pan B, Brunet LR, Hunt JR, Paton JF, van Kampen E, Knight DM, Evans AK, Rook GA, Lightman SL. Identification of an immune-responsive mesolimbocortical serotonergic system: potential role in regulation of emotional behavior. Neuroscience. 2007 May 11; 146(2):756-72. PMID: 17367941; PMCID: PMC1868963.
    90. Bouwknecht JA, Spiga F, Staub DR, Hale MW, Shekhar A, Lowry CA. Differential effects of exposure to low-light or high-light open-field on anxiety-related behaviors: relationship to c-Fos expression in serotonergic and non-serotonergic neurons in the dorsal raphe nucleus. Brain Res Bull. 2007 Apr 02; 72(1):32-43. PMID: 17303505; PMCID: PMC1800906.
    91. Evans AK, Lowry CA. Pharmacology of the beta-carboline FG-7,142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA A receptor: neurochemical, neurophysiological, and behavioral effects. CNS Drug Rev. 2007; 13(4):475-501. PMID: 18078430.
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    92. Hale MW, Bouwknecht JA, Spiga F, Shekhar A, Lowry CA. Exposure to high- and low-light conditions in an open-field test of anxiety increases c-Fos expression in specific subdivisions of the rat basolateral amygdaloid complex. Brain Res Bull. 2006 Dec 11; 71(1-3):174-82. PMID: 17113944.
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    93. Ruddick JP, Evans AK, Nutt DJ, Lightman SL, Rook GA, Lowry CA. Tryptophan metabolism in the central nervous system: medical implications. Expert Rev Mol Med. 2006 Aug 31; 8(20):1-27. PMID: 16942634.
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    94. Gasser PJ, Lowry CA, Orchinik M. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci. 2006 Aug 23; 26(34):8758-66. PMID: 16928864.
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    95. Evans AK, Abrams JK, Bouwknecht JA, Knight DM, Shekhar A, Lowry CA. The anxiogenic drug FG-7142 increases serotonin metabolism in the rat medial prefrontal cortex. Pharmacol Biochem Behav. 2006 Jun; 84(2):266-74. PMID: 16784772.
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    96. Hollis JH, Evans AK, Bruce KP, Lightman SL, Lowry CA. Lipopolysaccharide has indomethacin-sensitive actions on Fos expression in topographically organized subpopulations of serotonergic neurons. Brain Behav Immun. 2006 Nov; 20(6):569-77. PMID: 16554144.
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    97. Spiga F, Lightman SL, Shekhar A, Lowry CA. Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons. Neuroscience. 2006; 138(4):1265-76. PMID: 16488545.
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    98. Lowry CA, Moore FL. Regulation of behavioral responses by corticotropin-releasing factor. Gen Comp Endocrinol. 2006 Mar; 146(1):19-27. PMID: 16426606.
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    99. Staub DR, Evans AK, Lowry CA. Evidence supporting a role for corticotropin-releasing factor type 2 (CRF2) receptors in the regulation of subpopulations of serotonergic neurons. Brain Res. 2006 Jan 27; 1070(1):77-89. PMID: 16403469.
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    100. Lowry CA, Johnson PL, Hay-Schmidt A, Mikkelsen J, Shekhar A. Modulation of anxiety circuits by serotonergic systems. Stress. 2005 Dec; 8(4):233-46. PMID: 16423712.
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    101. de Vries A, Paton JF, Lightman SL, Lowry CA. Characterisation of c-Fos expression in the central nervous system of mice following right atrial injections of the 5-HT3 receptor agonist phenylbiguanide. Auton Neurosci. 2005 Dec 30; 123(1-2):62-75. PMID: 16298172.
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    102. Feng N, Mo B, Johnson PL, Orchinik M, Lowry CA, Renner KJ. Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus. Brain Res. 2005 Nov 23; 1063(1):69-76. PMID: 16266691.
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    103. Gardner KL, Thrivikraman KV, Lightman SL, Plotsky PM, Lowry CA. Early life experience alters behavior during social defeat: focus on serotonergic systems. Neuroscience. 2005; 136(1):181-91. PMID: 16182451.
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    104. Johnson PL, Hollis JH, Moratalla R, Lightman SL, Lowry CA. Acute hypercarbic gas exposure reveals functionally distinct subpopulations of serotonergic neurons in rats. J Psychopharmacol. 2005 Jul; 19(4):327-41. PMID: 15982987.
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    105. Johnson PL, Moratalla R, Lightman SL, Lowry CA. Are tuberomammillary histaminergic neurons involved in CO2-mediated arousal? Exp Neurol. 2005 May; 193(1):228-33. PMID: 15817281.
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    106. Staub DR, Spiga F, Lowry CA. Urocortin 2 increases c-Fos expression in topographically organized subpopulations of serotonergic neurons in the rat dorsal raphe nucleus. Brain Res. 2005 May 24; 1044(2):176-89. PMID: 15885216.
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    107. Henry BA, Lightman SL, Lowry CA. Distribution of corticotropin-releasing factor binding protein-immunoreactivity in the rat hypothalamus: association with corticotropin-releasing factor-, urocortin 1- and vimentin-immunoreactive fibres. J Neuroendocrinol. 2005 Mar; 17(3):135-44. PMID: 15796765.
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    108. Hollis JH, Lightman SL, Lowry CA. Lipopolysaccharide has selective actions on sub-populations of catecholaminergic neurons involved in activation of the hypothalamic-pituitary-adrenal axis and inhibition of prolactin secretion. J Endocrinol. 2005 Feb; 184(2):393-406. PMID: 15684347.
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    109. Abrams JK, Johnson PL, Hay-Schmidt A, Mikkelsen JD, Shekhar A, Lowry CA. Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs. Neuroscience. 2005; 133(4):983-97. PMID: 15916857.
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    110. Hollis JH, Lightman SL, Lowry CA. Integration of systemic and visceral sensory information by medullary catecholaminergic systems during peripheral inflammation. Ann N Y Acad Sci. 2004 Jun; 1018:71-5. PMID: 15240354.
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    111. Abrams JK, Johnson PL, Hollis JH, Lowry CA. Anatomic and functional topography of the dorsal raphe nucleus. Ann N Y Acad Sci. 2004 Jun; 1018:46-57. PMID: 15240351.
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    112. Johnson PL, Lightman SL, Lowry CA. A functional subset of serotonergic neurons in the rat ventrolateral periaqueductal gray implicated in the inhibition of sympathoexcitation and panic. Ann N Y Acad Sci. 2004 Jun; 1018:58-64. PMID: 15240352.
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    113. Kaye J, Buchanan F, Kendrick A, Johnson P, Lowry C, Bailey J, Nutt D, Lightman S. Acute carbon dioxide exposure in healthy adults: evaluation of a novel means of investigating the stress response. J Neuroendocrinol. 2004 Mar; 16(3):256-64. PMID: 15049856.
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    114. Summers CH, Kampshoff JL, Ronan PJ, Lowry CA, Prestbo AA, Korzan WJ, Renner KJ. Monoaminergic activity in subregions of raphé nuclei elicited by prior stress and the neuropeptide corticotropin-releasing factor. J Neuroendocrinol. 2003 Dec; 15(12):1122-33. PMID: 14636174.
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    115. Lowry CA, Plant A, Shanks N, Ingram CD, Lightman SL. Anatomical and functional evidence for a stress-responsive, monoamine-accumulating area in the dorsomedial hypothalamus of adult rat brain. Horm Behav. 2003 Jan; 43(1):254-62. PMID: 12614657.
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    116. Lowry CA. Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitary-adrenal axis. J Neuroendocrinol. 2002 Nov; 14(11):911-23. PMID: 12421345.
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    117. Oldfield S, Lowry C, Ruddick J, Lightman S. ABCG4: a novel human white family ABC-transporter expressed in the brain and eye. Biochim Biophys Acta. 2002 Aug 19; 1591(1-3):175-9. PMID: 12183068.
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    118. Kirov G, Lowry CA, Stephens M, Oldfield S, O'Donovan MC, Lightman SL, Owen MJ. Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder. Mol Psychiatry. 2001 Nov; 6(6):671-7. PMID: 11673795.
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    119. Lowry CA, Burke KA, Renner KJ, Moore FL, Orchinik M. Rapid changes in monoamine levels following administration of corticotropin-releasing factor or corticosterone are localized in the dorsomedial hypothalamus. Horm Behav. 2001 May; 39(3):195-205. PMID: 11300710.
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    120. Krakow B, Lowry C, Germain A, Gaddy L, Hollifield M, Koss M, Tandberg D, Johnston L, Melendrez D. A retrospective study on improvements in nightmares and post-traumatic stress disorder following treatment for co-morbid sleep-disordered breathing. J Psychosom Res. 2000 Nov; 49(5):291-8. PMID: 11164053.
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    121. Lowry CA, Rodda JE, Lightman SL, Ingram CD. Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical serotonergic system. J Neurosci. 2000 Oct 15; 20(20):7728-36. PMID: 11027235.
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    122. Moore FL, Richardson C, Lowry CA. Sexual dimorphism in numbers of vasotocin-immunoreactive neurons in brain areas associated with reproductive behaviors in the roughskin newt. Gen Comp Endocrinol. 2000 Feb; 117(2):281-98. PMID: 10642450.
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    123. Lambert KG, Quadros P, Aurentz C, Lowry C, Kinsley CH. Does chronic activity-stress produce hippocampal atrophy and basal forebrain lesions? A preliminary analysis. Ann N Y Acad Sci. 1999 Jun 29; 877:742-6. PMID: 10415696.
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    124. Moore FL, Lowry CA. Comparative neuroanatomy of vasotocin and vasopressin in amphibians and other vertebrates. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Jun; 119(3):251-60. PMID: 9826998.
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    125. Lowry CA, Richardson CF, Zoeller TR, Miller LJ, Muske LE, Moore FL. Neuroanatomical distribution of vasotocin in a urodele amphibian (Taricha granulosa) revealed by immunohistochemical and in situ hybridization techniques. J Comp Neurol. 1997 Aug 18; 385(1):43-70. PMID: 9268116.
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    126. Zoeller RT, Fletcher DL, Butnariu O, Lowry CA, Moore FL. N-ethylmaleimide (NEM) can significantly improve in situ hybridization results using 35S-labeled oligodeoxynucleotide or complementary RNA probes. J Histochem Cytochem. 1997 Jul; 45(7):1035-41. PMID: 9212828.
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    127. Lowry CA, Rose JD, Moore FL. Corticotropin-releasing factor enhances locomotion and medullary neuronal firing in an amphibian. Horm Behav. 1996 Mar; 30(1):50-9. PMID: 8724179.
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    128. Lowry CA, Renner KJ, Moore FL. Catecholamines and indoleamines in the central nervous system of a urodele amphibian: a microdissection study with emphasis on the distribution of epinephrine. Brain Behav Evol. 1996; 48(2):70-93. PMID: 8853874.
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    129. Moore FL, Orchinik M, Lowry C. Functional studies of corticosterone receptors in neuronal membranes. Receptor. 1995; 5(1):21-8. PMID: 7613480.
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    130. Moore FL, Lowry CA, Rose JD. Steroid-neuropeptide interactions that control reproductive behaviors in an amphibian. Psychoneuroendocrinology. 1994; 19(5-7):581-92. PMID: 7938356.
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    131. Lowry CA, Moore FL. Corticotropin-releasing factor (CRF) antagonist suppresses stress-induced locomotor activity in an amphibian. Horm Behav. 1991 Mar; 25(1):84-96. PMID: 1646155.
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    132. Lowry CA, Deviche P, Moore FL. Effects of corticotropin-releasing factor (CRF) and opiates on amphibian locomotion. Brain Res. 1990 Apr 09; 513(1):94-100. PMID: 2161698.
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    133. Deviche P, Lowry CA, Moore FL. Opiate control of spontaneous locomotor activity in a urodele amphibian. Pharmacol Biochem Behav. 1989 Dec; 34(4):753-7. PMID: 2560213.
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    134. Scobie IN, Saunders J, Barnes GD, Hoad J, Wheeler MJ, Lowry C, Sonksen PH, Amphlett G, Riley AJ. A comparative study of the effects of ranitidine and cimetidine on carbohydrate tolerance, growth hormone secretion and the hypothalamic-pituitary-gonadal axis in man. Curr Med Res Opin. 1986; 10(5):285-90. PMID: 3545685.
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