Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Last Name

Contact Us
If you have any questions or feedback please contact us.

Jefferson D. Knight

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Denver Campus

    Collapse Research 
    Collapse research activities and funding
    R15GM102866     (KNIGHT, JEFFERSON D.)Feb 1, 2014 - May 31, 2020
    Ca2+-independent and Ca2+-inhibited membrane binding by synaptotagmin-like proteins
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Tran HT, Anderson LH, Knight JD. Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7. Biophys J. 2019 Mar 19; 116(6):1025-1036. PMID: 30795874.
      View in: PubMed
    2. Schenk NA, Dahl PJ, Hanna MG, Audhya A, Tall GG, Knight JD, Anantharam A. A simple supported tubulated bilayer system for evaluating protein-mediated membrane remodeling. Chem Phys Lipids. 2018 Sep; 215:18-28. PMID: 30012406.
      View in: PubMed
    3. MacDougall DD, Lin Z, Chon NL, Jackman SL, Lin H, Knight JD, Anantharam A. The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis. J Gen Physiol. 2018 Jun 04; 150(6):783-807. PMID: 29794152.
      View in: PubMed
    4. Bendahmane M, Bohannon KP, Bradberry MM, Rao TC, Schmidtke MW, Abbineni PS, Chon NL, Tran S, Lin H, Chapman ER, Knight JD, Anantharam A. The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion. Mol Biol Cell. 2018 Feb 14. PMID: 29444959.
      View in: PubMed
    5. Hamilton DJ, Coffman MD, Knight JD, Reed SM. Lipid-Coated Gold Nanoparticles and FRET Allow Sensitive Monitoring of Liposome Clustering Mediated by the Synaptotagmin-7 C2A Domain. Langmuir. 2017 09 12; 33(36):9222-9230. PMID: 28850236.
      View in: PubMed
    6. Osterberg JR, Chon NL, Boo A, Maynard FA, Lin H, Knight JD. Membrane Docking of the Synaptotagmin 7 C2A Domain: Electron Paramagnetic Resonance Measurements Show Contributions from Two Membrane Binding Loops. Biochemistry. 2015 Sep 22; 54(37):5684-95. PMID: 26322740; PMCID: PMC4630001 [Available on 09/22/16].
    7. Chon NL, Osterberg JR, Henderson J, Khan HM, Reuter N, Knight JD, Lin H. Membrane Docking of the Synaptotagmin 7 C2A Domain: Computation Reveals Interplay between Electrostatic and Hydrophobic Contributions. Biochemistry. 2015 Sep 22; 54(37):5696-711. PMID: 26333120.
      View in: PubMed
    8. Vasquez JK, Chantranuvatana K, Giardina DT, Coffman MD, Knight JD. Lateral diffusion of proteins on supported lipid bilayers: additive friction of synaptotagmin 7 C2A-C2B tandem domains. Biochemistry. 2014 Dec 23; 53(50):7904-13. PMID: 25437758; PMCID: PMC4278679.
    9. Ziemba BP, Li J, Landgraf KE, Knight JD, Voth GA, Falke JJ. Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-a. Biochemistry. 2014 Mar 18; 53(10):1697-713. PMID: 24559055; PMCID: PMC3971957.
    10. Lyakhova TA, Knight JD. The C2 domains of granuphilin are high-affinity sensors for plasma membrane lipids. Chem Phys Lipids. 2014 Sep; 182:29-37. PMID: 24184645.
      View in: PubMed
    11. Yamamoto TM, Cook JM, Kotter CV, Khat T, Silva KD, Ferreyros M, Holt JW, Knight JD, Charlesworth A. Zar1 represses translation in Xenopus oocytes and binds to the TCS in maternal mRNAs with different characteristics than Zar2. Biochim Biophys Acta. 2013 Oct; 1829(10):1034-46. PMID: 23827238; PMCID: PMC3810179.
    12. Brandt DS, Coffman MD, Falke JJ, Knight JD. Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7. Biochemistry. 2012 Oct 02; 51(39):7654-64. PMID: 22966849; PMCID: PMC3494482.
    13. Ziemba BP, Knight JD, Falke JJ. Assembly of membrane-bound protein complexes: detection and analysis by single molecule diffusion. Biochemistry. 2012 Feb 28; 51(8):1638-47. PMID: 22263647; PMCID: PMC3318961.
    14. Knight JD, Lerner MG, Marcano-Velázquez JG, Pastor RW, Falke JJ. Single molecule diffusion of membrane-bound proteins: window into lipid contacts and bilayer dynamics. Biophys J. 2010 Nov 03; 99(9):2879-87. PMID: 21044585; PMCID: PMC2966005.
    15. Knight JD, Falke JJ. Single-molecule fluorescence studies of a PH domain: new insights into the membrane docking reaction. Biophys J. 2009 Jan; 96(2):566-82. PMID: 19167305; PMCID: PMC2716689.
    16. Knight JD, Williamson JA, Miranker AD. Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin. Protein Sci. 2008 Oct; 17(10):1850-6. PMID: 18765820; PMCID: PMC2548354.
    17. Knight JD, Hebda JA, Miranker AD. Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide. Biochemistry. 2006 Aug 08; 45(31):9496-508. PMID: 16878984.
      View in: PubMed
    18. Knight JD, Miranker AD. Phospholipid catalysis of diabetic amyloid assembly. J Mol Biol. 2004 Aug 27; 341(5):1175-87. PMID: 15321714.
      View in: PubMed
    19. Eakin CM, Knight JD, Morgan CJ, Gelfand MA, Miranker AD. Formation of a copper specific binding site in non-native states of beta-2-microglobulin. Biochemistry. 2002 Aug 27; 41(34):10646-56. PMID: 12186550.
      View in: PubMed
    Knight's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    Co-Authors Expand Description
    Similar People Expand Description
    Same Department Expand Description
    Physical Neighbors Expand Description

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)