 Synaptotagmin I
"Synaptotagmin I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vesicular transport protein expressed predominately in NEURONS. Synaptotagmin helps regulate EXOCYTOSIS of SYNAPTIC VESICLES and appears to serve as a calcium sensor to trigger NEUROTRANSMITTER release. It also acts as a nerve cell receptor for certain BOTULINUM TOXINS.
| Descriptor ID |
D050863
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| MeSH Number(s) |
D12.776.157.125.825.249 D12.776.543.990.850.249
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| Concept/Terms |
Synaptotagmin I- Synaptotagmin I
- p65 Protein (Synaptotagmin I)
- Synaptic Vesicle Protein p65
- Synaptotagmin 1
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Below are MeSH descriptors whose meaning is more general than "Synaptotagmin I".
Below are MeSH descriptors whose meaning is more specific than "Synaptotagmin I".
This graph shows the total number of publications written about "Synaptotagmin I" by people in this website by year, and whether "Synaptotagmin I" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 | | 2012 | 2 | 0 | 2 | | 2014 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Synaptotagmin I" by people in Profiles.
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Chon NL, Tran S, Miller CS, Lin H, Knight JD. A conserved electrostatic membrane-binding surface in synaptotagmin-like proteins revealed using molecular phylogenetic analysis and homology modeling. Protein Sci. 2024 Jan; 33(1):e4850.
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Tran HT, Anderson LH, Knight JD. Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7. Biophys J. 2019 03 19; 116(6):1025-1036.
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Hamilton DJ, Coffman MD, Knight JD, Reed SM. Lipid-Coated Gold Nanoparticles and FRET Allow Sensitive Monitoring of Liposome Clustering Mediated by the Synaptotagmin-7 C2A Domain. Langmuir. 2017 09 12; 33(36):9222-9230.
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Vasquez JK, Chantranuvatana K, Giardina DT, Coffman MD, Knight JD. Lateral diffusion of proteins on supported lipid bilayers: additive friction of synaptotagmin 7 C2A-C2B tandem domains. Biochemistry. 2014 Dec 23; 53(50):7904-13.
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Brandt DS, Coffman MD, Falke JJ, Knight JD. Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7. Biochemistry. 2012 Oct 02; 51(39):7654-64.
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Saludes JP, Morton LA, Ghosh N, Beninson LA, Chapman ER, Fleshner M, Yin H. Detection of highly curved membrane surfaces using a cyclic peptide derived from synaptotagmin-I. ACS Chem Biol. 2012 Oct 19; 7(10):1629-35.
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Vrljic M, Strop P, Hill RC, Hansen KC, Chu S, Brunger AT. Post-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1. Biochemistry. 2011 Nov 22; 50(46):9998-10012.
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Schulze-Sp?te U, Battaglino R, Fu J, Sharma A, Vokes M, Stashenko P. Brn3 transcription factors control terminal osteoclastogenesis. J Cell Biochem. 2007 Sep 01; 102(1):1-12.
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Evans JH, Gerber SH, Murray D, Leslie CC. The calcium binding loops of the cytosolic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cells. Mol Biol Cell. 2004 Jan; 15(1):371-83.
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