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Sean P Colgan

TitleDistinguished Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    R01DK131581     (LOZUPONE, CATHERINE)Aug 1, 2022 - May 31, 2027
    NIH
    Gut microbiome effects on intestinal barrier function and metabolic syndrome in HIV positive men who have sex with men
    Role: Co-Principal Investigator
    R01DK103712     (COLGAN, SEAN P)Jul 1, 2015 - Jun 30, 2021
    NIH
    METABOLIC CONTROL OF EPITHELIAL AUTOPHAGY DURING INFLAMMATION
    Role: Principal Investigator
    R01DK104713     (COLGAN, SEAN P)Apr 1, 2015 - Mar 31, 2024
    NIH
    Metabolic Regulation of Inflammation by Microbial-Derived Short Chain Fatty Acids
    Role: Principal Investigator
    I01BX002182     (COLGAN, SEAN P)Apr 1, 2014 - Dec 31, 2022
    NIH
    Metabolic Regulation of Mucosal Inflammation
    Role: Principal Investigator
    R01DK095491     (COLGAN, SEAN P)Jun 1, 2012 - Dec 31, 2024
    NIH
    Mechanisms of Adenosine Protection
    Role: Principal Investigator
    R13DK093264     (WU, GARY D.)Aug 1, 2011 - Jul 31, 2012
    NIH
    FASEB SRC on Gastrointestinal Tract XIV: Stem Cells, Adaptation, Inflammation and
    Role: Co-Principal Investigator
    R21DK065768     (COLGAN, SEAN P)Jun 1, 2004 - May 31, 2007
    NIH
    Epithelial BPI and intestinal inflammation
    Role: Principal Investigator
    R01HL060569     (COLGAN, SEAN P)Apr 1, 1999 - Feb 28, 2015
    NIH
    Hypoxia and Inflammation at the Vascular Interface
    Role: Principal Investigator
    R01DK050189     (COLGAN, SEAN P)Sep 25, 1995 - Mar 31, 2025
    NIH
    Hypoxia, HIF, and Mucosal Inflammation
    Role: Principal Investigator
    R37DK050189     (COLGAN, SEAN P)Sep 25, 1995 - Jun 30, 2021
    NIH
    Hypoxia, HIF, and Mucosal Inflammation
    Role: Principal Investigator
    R29DK050189     (COLGAN, SEAN P)Sep 25, 1995 - Aug 31, 2000
    NIH
    EPITHELIA AND ISCHEMIA/REPERFUSION INJURY
    Role: Principal Investigator
    F32DK008777     (COLGAN, SEAN P)Feb 10, 1993
    NIH
    CYTOKINE EFFECTS ON INTESTINAL INFLAMMATION
    Role: Principal Investigator
    P30DK034854     (LENCER, WAYNE I)Sep 30, 1984 - Mar 31, 2026
    NIH
    Integrated Epithelial and Muscosal Biology
    Role: Co-Principal Investigator
    T32DK007038     (COLGAN, SEAN P)Jul 1, 1975 - Jun 30, 2021
    NIH
    Gastrointestinal Diseases Training Grant
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Seymour BJ, Trent B, Allen BE, Berlinberg AJ, Tangchittsumran J, Jubair WK, Chriswell ME, Liu S, Ornelas A, Stahly A, Alexeev EE, Dowdell AS, Sneed SL, Fechtner S, Kofonow JM, Robertson CE, Dillon SM, Wilson CC, Anthony RM, Frank DN, Colgan SP, Kuhn KA. Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice. J Clin Invest. 2023 Dec 19; 134(4). PMID: 38113112.
      View in: PubMed
    2. Alula KM, Dowdell AS, LeBere B, Lee JS, Levens CL, Kuhn KA, Kaipparettu BA, Thompson WE, Blumberg RS, Colgan SP, Theiss AL. Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in mice. Microbiome. 2023 11 17; 11(1):256. PMID: 37978573.
      View in: PubMed
    3. Seymour BJ, Trent B, Allen B, Berlinberg AJ, Tangchittsumran J, Jubair WK, Chriswell ME, Liu S, Ornelas A, Stahly A, Alexeev EE, Dowdell AS, Sneed SL, Fechtner S, Kofonow JM, Robertson CE, Dillon SM, Wilson CC, Anthony RM, Frank DN, Colgan SP, Kuhn KA. Microbiota-dependent indole production is required for the development of collagen-induced arthritis. bioRxiv. 2023 Oct 13. PMID: 37873395.
      View in: PubMed
    4. Ornelas A, Welch N, Countess JA, Zhou L, Wang RX, Dowdell AS, Colgan SP. Mimicry of microbially-derived butyrate reveals templates for potent intestinal epithelial HIF stabilizers. Gut Microbes. 2023 12; 15(2):2267706. PMID: 37822087.
      View in: PubMed
    5. Hall CHT, Lanis JM, Dowdell AS, Murphy EM, Bhagavatula G, Neuhart RM, Vijaya Sai KY, Colgan SP. Fundamental role for the creatine kinase pathway in protection from murine colitis. Mucosal Immunol. 2023 12; 16(6):817-825. PMID: 37716510.
      View in: PubMed
    6. Feng D, Xiang X, Guan Y, Guillot A, Lu H, Chang C, He Y, Wang H, Pan H, Ju C, Colgan SP, Tacke F, Wang XW, Kunos G, Gao B. Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models. J Clin Invest. 2023 08 01; 133(15). PMID: 37338984.
      View in: PubMed
    7. Vickery JM, Toperzer JD, Raab JE, Lenz LL, Colgan SP, Russo BC. Synaptopodin is necessary for Shigella flexneri intercellular spread. bioRxiv. 2023 Jun 26. PMID: 37163027.
      View in: PubMed
    8. Hall CH, Lanis JM, Dowdell AS, Murphy EM, Colgan SP. Fundamental role for the creatine kinase pathway in protection from murine colitis. bioRxiv. 2023 Jun 09. PMID: 37333192.
      View in: PubMed
    9. Steiner CA, Koch SD, Evanoff T, Welch N, Kostelecky R, Callahan R, Murphy EM, Nguyen TT, Hall CHT, Lu S, de Zoeten EF, Weiser-Evans MCM, Cartwright IM, Colgan SP. The TNF?ARE Mouse as a Model of Intestinal Fibrosis. Am J Pathol. 2023 08; 193(8):1013-1028. PMID: 37169343.
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    10. Cartwright IM, Colgan SP. The hypoxic tissue microenvironment as a driver of mucosal inflammatory resolution. Front Immunol. 2023; 14:1124774. PMID: 36742292.
      View in: PubMed
    11. Steiner CA, Koch SD, Evanoff T, Welch N, Kostelecky R, Callahan R, Murphy EM, Hall CHT, Lu S, Weiser-Evans MC, Cartwright IM, Colgan SP. The TNF ?ARE mouse as a model of intestinal fibrosis. bioRxiv. 2023 Jan 14. PMID: 36712048.
      View in: PubMed
    12. Colgan SP, Wang RX, Hall CHT, Bhagavatula G, Lee JS. Revisiting the "starved gut" hypothesis in inflammatory bowel disease. Immunometabolism (Cobham). 2023 Jan; 5(1):e0016. PMID: 36644501.
      View in: PubMed
    13. Dowdell AS, Cartwright IM, Kitzenberg DA, Kostelecky RE, Mahjoob O, Saeedi BJ, Welch N, Glover LE, Colgan SP. Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination. Cell Rep. 2022 09 27; 40(13):111409. PMID: 36170839.
      View in: PubMed
    14. Steiner CA, Cartwright IM, Taylor CT, Colgan SP. Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis. Am J Physiol Cell Physiol. 2022 09 01; 323(3):C866-C878. PMID: 35912990.
      View in: PubMed
    15. Cartwright IM, Dowdell AS, Hanson C, Kostelecky RE, Welch N, Steiner CA, Colgan SP. Contact-dependent, polarized acidification response during neutrophil-epithelial interactions. J Leukoc Biol. 2022 12; 112(6):1543-1553. PMID: 35674095.
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    16. de Graaf DM, Wang RX, Amo-Aparicio J, Lee JS, Dowdell AS, Tengesdal IW, Marchetti C, Colgan SP, Joosten LAB, Dinarello CA. IL-38 Gene Deletion Worsens Murine Colitis. Front Immunol. 2022; 13:840719. PMID: 35693797.
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    17. Kitzenberg DA, Lee JS, Mills KB, Kim JS, Liu L, V?zquez-Torres A, Colgan SP, Kao DJ. Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics. mBio. 2022 06 28; 13(3):e0048022. PMID: 35575513.
      View in: PubMed
    18. Ornelas A, Dowdell AS, Lee JS, Colgan SP. Microbial Metabolite Regulation of Epithelial Cell-Cell Interactions and Barrier Function. Cells. 2022 03 10; 11(6). PMID: 35326394.
      View in: PubMed
    19. Schaefer REM, Callahan RC, Atif SM, Orlicky DJ, Cartwright IM, Fontenot AP, Colgan SP, Onyiah JC. Disruption of monocyte-macrophage differentiation and trafficking by a heme analog during active inflammation. Mucosal Immunol. 2022 02; 15(2):244-256. PMID: 34916594.
      View in: PubMed
    20. Dowdell AS, Colgan SP. Metabolic Host-Microbiota Interactions in Autophagy and the Pathogenesis of Inflammatory Bowel Disease (IBD). Pharmaceuticals (Basel). 2021 Jul 22; 14(8). PMID: 34451805.
      View in: PubMed
    21. Colgan SP. HIF2 keeps paces in tight hypoxic spaces. Blood. 2021 06 17; 137(24):3323-3324. PMID: 34137846.
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    22. Cartwright IM, Colgan SP. In vitro Monitoring of Extracellular pH in Real-Time. J Vis Exp. 2021 06 03; (172). PMID: 34152309.
      View in: PubMed
    23. Cartwright IM, Dowdell AS, Lanis JM, Brink KR, Mu A, Kostelecky RE, Schaefer REM, Welch N, Onyiah JC, Hall CHT, Gerich ME, Tabor JJ, Colgan SP. Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation. Proc Natl Acad Sci U S A. 2021 05 18; 118(20). PMID: 33972436.
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    24. Cartwright IM, Colgan SP. Lung neutrophils on a paleo diet: lean, mean inflammatory machines. J Clin Invest. 2021 05 17; 131(10). PMID: 33998602.
      View in: PubMed
    25. Alexeev EE, Dowdell AS, Henen MA, Lanis JM, Lee JS, Cartwright IM, Schaefer REM, Ornelas A, Onyiah JC, V?geli B, Colgan SP. Microbial-derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage. FASEB J. 2021 05; 35(5):e21552. PMID: 33826788.
      View in: PubMed
    26. Wallimann T, Hall CHT, Colgan SP, Glover LE. Creatine Supplementation for Patients with Inflammatory Bowel Diseases: A Scientific Rationale for a Clinical Trial Nutrients. 2021 04 23; 13(5). PMID: 33922654.
      View in: PubMed
    27. Wang Y, Yang Y, Wang M, Wang S, Jeong JM, Xu L, Wen Y, Emontzpohl C, Atkins CL, Duong K, Moreno NF, Yuan X, Hall DR, Dar W, Feng D, Gao B, Xu Y, Czigany Z, Colgan SP, Bynon JS, Akira S, Brown JM, Eltzschig HK, Jacobsen EA, Ju C. Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production. Sci Transl Med. 2021 02 03; 13(579). PMID: 33536281.
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    28. Gally F, Sasse SK, Kurche JS, Gruca MA, Cardwell JH, Okamoto T, Chu HW, Hou X, Poirion OB, Buchanan J, Preissl S, Ren B, Colgan SP, Dowell RD, Yang IV, Schwartz DA, Gerber AN. The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling. JCI Insight. 2021 01 25; 6(2). PMID: 33320836.
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    29. Trikha SRJ, Lee DM, Ecton KE, Wrigley SD, Vazquez AR, Litwin NS, Thomas KN, Wei Y, Battson ML, Johnson SA, Kuhn KA, Colgan SP, Gentile CL, Weir TL. Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance. Gut Microbes. 2021 Jan-Dec; 13(1):1940791. PMID: 34313540.
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    30. Wang RX, Henen MA, Lee JS, V?geli B, Colgan SP. Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor. Gut Microbes. 2021 Jan-Dec; 13(1):1938380. PMID: 34190032.
      View in: PubMed
    31. Lee JS, Wang RX, Alexeev EE, Colgan SP. Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic. Gut Microbes. 2021 Jan-Dec; 13(1):1-20. PMID: 33583319.
      View in: PubMed
    32. Gao RY, Shearn CT, Orlicky DJ, Battista KD, Alexeev EE, Cartwright IM, Lanis JM, Kostelecky RE, Ju C, Colgan SP, Fennimore BP. Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis. Mucosal Immunol. 2021 03; 14(2):479-490. PMID: 33004979.
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    33. Dowdell AS, Cartwright IM, Goldberg MS, Kostelecky R, Ross T, Welch N, Glover LE, Colgan SP. The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis. Mol Biol Cell. 2020 09 15; 31(20):2249-2258. PMID: 32726170.
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    34. Lee JS, Wang RX, Goldberg MS, Clifford GP, Kao DJ, Colgan SP. Microbiota-Sourced Purines Support Wound Healing and Mucous Barrier Function. iScience. 2020 Jun 26; 23(6):101226. PMID: 32554188.
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    35. Hall CHT, Lee JS, Murphy EM, Gerich ME, Dran R, Glover LE, Abdulla ZI, Skelton MR, Colgan SP. Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. Gastroenterology. 2020 09; 159(3):984-998.e1. PMID: 32433978.
      View in: PubMed
    36. Wang RX, Lee JS, Campbell EL, Colgan SP. Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin. Proc Natl Acad Sci U S A. 2020 05 26; 117(21):11648-11657. PMID: 32398370.
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    37. Colgan SP. Resolvins resolve to heal mucosal wounds. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):10621-10622. PMID: 32371481.
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    38. Liu G, Baird AW, Parsons MJ, Fan K, Skerrett-Byrne DA, Nair PM, Makanyengo S, Chen J, Neal R, Goggins BJ, Tay H, Mathe A, Soh WS, Minahan K, Hansbro PM, Nixon B, McCaughan GW, Holtmann G, Colgan SP, Keely S. Platelet activating factor receptor acts to limit colitis-induced liver inflammation. FASEB J. 2020 06; 34(6):7718-7732. PMID: 32293760.
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    39. deZoeten EF, Battista KD, Colson SB, Lovell MA, Kessler BE, Isfort RW, Fennimore BP, Onyiah JC, Kao DJ, Yeckes A, Keely S, Murray M, Hoffenberg EJ, Colgan SP, Gerich ME. Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in Inflammatory Bowel Disease. Hypoxia (Auckl). 2020; 8:1-12. PMID: 32104717.
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    40. Gao RY, Wang M, Liu Q, Feng D, Wen Y, Xia Y, Colgan SP, Eltzschig HK, Ju C. Hypoxia-Inducible Factor-2a Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6. Hepatology. 2020 06; 71(6):2105-2117. PMID: 31529728.
      View in: PubMed
    41. Colgan SP, Furuta GT, Taylor CT. Hypoxia and Innate Immunity: Keeping Up with the HIFsters. Annu Rev Immunol. 2020 04 26; 38:341-363. PMID: 31961750.
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    42. Cartwright IM, Curtis VF, Lanis JM, Alexeev EE, Welch N, Goldberg MS, Schaefer REM, Gao RY, Chun C, Fennimore B, Onyiah JC, Gerich ME, Dempsey PJ, Colgan SP. Adaptation to inflammatory acidity through neutrophil-derived adenosine regulation of SLC26A3. Mucosal Immunol. 2020 03; 13(2):230-244. PMID: 31792360.
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    43. Oyama Y, Bartman CM, Bonney S, Lee JS, Walker LA, Han J, Borchers CH, Buttrick PM, Aherne CM, Clendenen N, Colgan SP, Eckle T. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Rep. 2019 08 06; 28(6):1471-1484.e11. PMID: 31390562.
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    44. Shearn CT, Fennimore B, Orlicky DJ, Gao YR, Saba LM, Battista KD, Aivazidis S, Assiri M, Harris PS, Michel C, Merrill GF, Schmidt EE, Colgan SP, Petersen DR. Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response. Free Radic Biol Med. 2019 11 01; 143:101-114. PMID: 31377417.
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    45. Masterson JC, Biette KA, Hammer JA, Nguyen N, Capocelli KE, Saeedi BJ, Harris RF, Fernando SD, Hosford LB, Kelly CJ, Campbell EL, Ehrentraut SF, Ahmed FN, Nakagawa H, Lee JJ, McNamee EN, Glover LE, Colgan SP, Furuta GT. Epithelial HIF-1a/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis. J Clin Invest. 2019 07 02; 129(8):3224-3235. PMID: 31264974.
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    46. Kelly CJ, Alexeev EE, Farb L, Vickery TW, Zheng L, Eric L C, Kitzenberg DA, Battista KD, Kominsky DJ, Robertson CE, Frank DN, Stabler SP, Colgan SP. Oral vitamin B12 supplement is delivered to the distal gut, altering the corrinoid profile and selectively depleting Bacteroides in C57BL/6 mice. Gut Microbes. 2019; 10(6):654-662. PMID: 31062653.
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    47. Campbell EL, Colgan SP. Control and dysregulation of redox signalling in the gastrointestinal tract. Nat Rev Gastroenterol Hepatol. 2019 02; 16(2):106-120. PMID: 30443019.
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    48. Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT. Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Cancer Cell. 2018 10 08; 34(4):659-673.e6. PMID: 30270124.
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    49. Curtis VF, Cartwright IM, Lee JS, Wang RX, Kao DJ, Lanis JM, Burney KM, Welch N, Hall CHT, Goldberg MS, Campbell EL, Colgan SP. Neutrophils as sources of dinucleotide polyphosphates and metabolism by epithelial ENPP1 to influence barrier function via adenosine signaling. Mol Biol Cell. 2018 11 01; 29(22):2687-2699. PMID: 30188771.
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    50. Onyiah JC, Schaefer REM, Colgan SP. A Central Role for Heme Oxygenase-1 in the Control of Intestinal Epithelial Chemokine Expression. J Innate Immun. 2018; 10(3):228-238. PMID: 29791903.
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    51. Lee JS, Wang RX, Alexeev EE, Lanis JM, Battista KD, Glover LE, Colgan SP. Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function. J Biol Chem. 2018 04 20; 293(16):6039-6051. PMID: 29487135.
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    52. Alexeev EE, Lanis JM, Kao DJ, Campbell EL, Kelly CJ, Battista KD, Gerich ME, Jenkins BR, Walk ST, Kominsky DJ, Colgan SP. Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor. Am J Pathol. 2018 05; 188(5):1183-1194. PMID: 29454749.
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    53. Taylor CT, Colgan SP. Regulation of immunity and inflammation by hypoxia in immunological niches. Nat Rev Immunol. 2017 Dec; 17(12):774-785. PMID: 28972206.
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    54. Kao DJ, Saeedi BJ, Kitzenberg D, Burney KM, Dobrinskikh E, Battista KD, V?zquez-Torres A, Colgan SP, Kominsky DJ. Intestinal Epithelial Ecto-5'-Nucleotidase (CD73) Regulates Intestinal Colonization and Infection by Nontyphoidal Salmonella. Infect Immun. 2017 10; 85(10). PMID: 28717030.
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    55. Zheng L, Kelly CJ, Battista KD, Schaefer R, Lanis JM, Alexeev EE, Wang RX, Onyiah JC, Kominsky DJ, Colgan SP. Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2. J Immunol. 2017 10 15; 199(8):2976-2984. PMID: 28893958.
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    56. Glover LE, Colgan SP. Epithelial Barrier Regulation by Hypoxia-Inducible Factor. Ann Am Thorac Soc. 2017 Sep; 14(Supplement_3):S233-S236. PMID: 28945477.
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    57. Neudecker V, Colgan SP, Eltzschig HK. Novel therapeutic concepts for inflammatory bowel disease-from bench to bedside. J Mol Med (Berl). 2017 09; 95(9):899-903. PMID: 28780611.
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    58. Nguyen N, Fernando SD, Biette KA, Hammer JA, Capocelli KE, Kitzenberg DA, Glover LE, Colgan SP, Furuta GT, Masterson JC. TGF-?1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis. Mucosal Immunol. 2018 03; 11(2):415-426. PMID: 28832026.
      View in: PubMed
    59. Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, Whitney AK, Ir D, Ohri N, Robertson CE, Frank DN, Campbell EL, Colgan SP. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity. Mucosal Immunol. 2018 03; 11(2):357-368. PMID: 28812548.
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    60. Hall CHT, Campbell EL, Colgan SP. Neutrophils as Components of Mucosal Homeostasis. Cell Mol Gastroenterol Hepatol. 2017 Nov; 4(3):329-337. PMID: 28884136.
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    61. Colgan SP, Campbell EL. Oxygen metabolism and innate immune responses in the gut. J Appl Physiol (1985). 2017 Nov 01; 123(5):1321-1327. PMID: 28705991.
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    62. McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL. Hypoxia-Inducible Factor 1a Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury. Am J Pathol. 2017 Aug; 187(8):1772-1786. PMID: 28618253.
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    63. Lanis JM, Kao DJ, Alexeev EE, Colgan SP. Tissue metabolism and the inflammatory bowel diseases. J Mol Med (Berl). 2017 Sep; 95(9):905-913. PMID: 28528514.
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    64. Wang RX, Colgan SP. Special pro-resolving mediator (SPM) actions in regulating gastro-intestinal inflammation and gut mucosal immune responses. Mol Aspects Med. 2017 Dec; 58:93-101. PMID: 28232096.
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    65. Lanis JM, Alexeev EE, Curtis VF, Kitzenberg DA, Kao DJ, Battista KD, Gerich ME, Glover LE, Kominsky DJ, Colgan SP. Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia. Mucosal Immunol. 2017 09; 10(5):1133-1144. PMID: 28098246.
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    66. Chun C, Zheng L, Colgan SP. Tissue metabolism and host-microbial interactions in the intestinal mucosa. Free Radic Biol Med. 2017 04; 105:86-92. PMID: 27687211.
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    67. Ehrentraut SF, Curtis VF, Wang RX, Saeedi BJ, Ehrentraut H, Onyiah JC, Kelly CJ, Campbell EL, Glover LE, Kominsky DJ, Colgan SP. Perturbation of neddylation-dependent NF-?B responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation. Mol Biol Cell. 2016 Sep 28. PMID: 27682585.
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    68. Campbell EL, Kao DJ, Colgan SP. Neutrophils and the inflammatory tissue microenvironment in the mucosa. Immunol Rev. 2016 09; 273(1):112-20. PMID: 27558331.
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    69. Kitzenberg D, Colgan SP, Glover LE. Creatine kinase in ischemic and inflammatory disorders. Clin Transl Med. 2016 Dec; 5(1):31. PMID: 27527620.
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    70. Glover LE, Lee JS, Colgan SP. Oxygen metabolism and barrier regulation in the intestinal mucosa. J Clin Invest. 2016 10 03; 126(10):3680-3688. PMID: 27500494.
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    71. Frasch SC, McNamee EN, Kominsky D, Jedlicka P, Jakubzick C, Zemski Berry K, Mack M, Furuta GT, Lee JJ, Henson PM, Colgan SP, Bratton DL. G2A Signaling Dampens Colitic Inflammation via Production of IFN-?. J Immunol. 2016 08 15; 197(4):1425-34. PMID: 27402702.
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    72. Onyiah JC, Colgan SP. Cytokine responses and epithelial function in the intestinal mucosa. Cell Mol Life Sci. 2016 11; 73(22):4203-4212. PMID: 27271753.
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    73. Colgan SP, Campbell EL, Kominsky DJ. Hypoxia and Mucosal Inflammation. Annu Rev Pathol. 2016 05 23; 11:77-100. PMID: 27193451.
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    74. Ju C, Colgan SP, Eltzschig HK. Hypoxia-inducible factors as molecular targets for liver diseases. J Mol Med (Berl). 2016 06; 94(6):613-27. PMID: 27094811.
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    75. Kelly CJ, Colgan SP. Breathless in the Gut: Implications of Luminal O2 for Microbial Pathogenicity. Cell Host Microbe. 2016 Apr 13; 19(4):427-8. PMID: 27078062.
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    76. Selfridge AC, Cavadas MA, Scholz CC, Campbell EL, Welch LC, Lecuona E, Colgan SP, Barrett KE, Sporn PH, Sznajder JI, Cummins EP, Taylor CT. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J Biol Chem. 2016 May 27; 291(22):11800-8. PMID: 27044749.
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    77. Fu Q, Colgan SP, Shelley CS. Hypoxia: The Force that Drives Chronic Kidney Disease. Clin Med Res. 2016 Mar; 14(1):15-39. PMID: 26847481.
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    78. Colgan SP. Targeting hypoxia in inflammatory bowel disease. J Investig Med. 2016 Feb; 64(2):364-8. PMID: 26098381.
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    79. Zheng L, Kelly CJ, Colgan SP. Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia. Am J Physiol Cell Physiol. 2015 Sep 15; 309(6):C350-60. PMID: 26179603.
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    80. Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Erratum: Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 May; 8(3):699. PMID: 25943416.
      View in: PubMed
    81. Saeedi BJ, Kao DJ, Kitzenberg DA, Dobrinskikh E, Schwisow KD, Masterson JC, Kendrick AA, Kelly CJ, Bayless AJ, Kominsky DJ, Campbell EL, Kuhn KA, Furuta GT, Colgan SP, Glover LE. HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity. Mol Biol Cell. 2015 Jun 15; 26(12):2252-62. PMID: 25904334.
      View in: PubMed
    82. Kelly CJ, Zheng L, Campbell EL, Saeedi B, Scholz CC, Bayless AJ, Wilson KE, Glover LE, Kominsky DJ, Magnuson A, Weir TL, Ehrentraut SF, Pickel C, Kuhn KA, Lanis JM, Nguyen V, Taylor CT, Colgan SP. Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. Cell Host Microbe. 2015 May 13; 17(5):662-71. PMID: 25865369.
      View in: PubMed
    83. Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 Nov; 8(6):1324-38. PMID: 25850656.
      View in: PubMed
    84. Colgan SP, Curtis VF, Lanis JM, Glover LE. Metabolic regulation of intestinal epithelial barrier during inflammation. Tissue Barriers. 2015; 3(1-2):e970936. PMID: 25838978.
      View in: PubMed
    85. Colgan SP. Neutrophils and inflammatory resolution in the mucosa. Semin Immunol. 2015 May; 27(3):177-83. PMID: 25818531.
      View in: PubMed
    86. Campbell EL, Colgan SP. Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa. J Leukoc Biol. 2015 Oct; 98(4):517-22. PMID: 25714801.
      View in: PubMed
    87. Xiong W, Knox AJ, Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME. Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. Mol Endocrinol. 2015 Mar; 29(3):460-72. PMID: 25650755.
      View in: PubMed
    88. Eltzschig HK, Bratton DL, Colgan SP. Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases. Nat Rev Drug Discov. 2014 Nov; 13(11):852-69. PMID: 25359381.
      View in: PubMed
    89. Curtis VF, Ehrentraut SF, Campbell EL, Glover LE, Bayless A, Kelly CJ, Kominsky DJ, Colgan SP. Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. FASEB J. 2015 Jan; 29(1):208-15. PMID: 25326537.
      View in: PubMed
    90. Curtis VF, Ehrentraut SF, Colgan SP. Actions of adenosine on cullin neddylation: implications for inflammatory responses. Comput Struct Biotechnol J. 2015; 13:273-6. PMID: 25973141.
      View in: PubMed
    91. Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT. Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis. Gut. 2015 Aug; 64(8):1236-47. PMID: 25209655.
      View in: PubMed
    92. Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L, Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, Colgan SP. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 2014 Jan 16; 40(1):66-77. PMID: 24412613.
      View in: PubMed
    93. Eckle T, Kewley EM, Brodsky KS, Tak E, Bonney S, Gobel M, Anderson D, Glover LE, Riegel AK, Colgan SP, Eltzschig HK. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol. 2014 Feb 01; 192(3):1249-56. PMID: 24391213.
      View in: PubMed
    94. Kominsky DJ, Campbell EL, Ehrentraut SF, Wilson KE, Kelly CJ, Glover LE, Collins CB, Bayless AJ, Saeedi B, Dobrinskikh E, Bowers BE, MacManus CF, M?ller W, Colgan SP, Bruder D. IFN-?-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia. J Immunol. 2014 Feb 01; 192(3):1267-76. PMID: 24367025.
      View in: PubMed
    95. Glover LE, Bowers BE, Saeedi B, Ehrentraut SF, Campbell EL, Bayless AJ, Dobrinskikh E, Kendrick AA, Kelly CJ, Burgess A, Miller L, Kominsky DJ, Jedlicka P, Colgan SP. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19820-5. PMID: 24248342.
      View in: PubMed
    96. Weissm?ller T, Glover LE, Fennimore B, Curtis VF, MacManus CF, Ehrentraut SF, Campbell EL, Scully M, Grove BD, Colgan SP. HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function. FASEB J. 2014 Jan; 28(1):256-64. PMID: 24029533.
      View in: PubMed
    97. Colgan SP, Curtis VF, Campbell EL. The inflammatory tissue microenvironment in IBD. Inflamm Bowel Dis. 2013 Sep; 19(10):2238-44. PMID: 23702808.
      View in: PubMed
    98. Keely S, Campbell EL, Baird AW, Hansbro PM, Shalwitz RA, Kotsakis A, McNamee EN, Eltzschig HK, Kominsky DJ, Colgan SP. Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. Mucosal Immunol. 2014 Jan; 7(1):114-23. PMID: 23695513.
      View in: PubMed
    99. Zhang W, Zhang Y, Wang W, Dai Y, Ning C, Luo R, Sun K, Glover L, Grenz A, Sun H, Tao L, Zhang W, Colgan SP, Blackburn MR, Eltzschig HK, Kellems RE, Xia Y. Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension. Circ Res. 2013 May 24; 112(11):1466-78. PMID: 23584256.
      View in: PubMed
    100. Kelly CJ, Glover LE, Campbell EL, Kominsky DJ, Ehrentraut SF, Bowers BE, Bayless AJ, Saeedi BJ, Colgan SP. Fundamental role for HIF-1a in constitutive expression of human ? defensin-1. Mucosal Immunol. 2013 Nov; 6(6):1110-8. PMID: 23462909.
      View in: PubMed
    101. Colgan SP. Swimming through the gut: implications of fluid transport on the microbiome. Dig Dis Sci. 2013 Mar; 58(3):602-3. PMID: 23361577.
      View in: PubMed
    102. Colgan SP, Ehrentraut SF, Glover LE, Kominsky DJ, Campbell EL. Contributions of neutrophils to resolution of mucosal inflammation. Immunol Res. 2013 Mar; 55(1-3):75-82. PMID: 22968707.
      View in: PubMed
    103. Ehrentraut H, Clambey ET, McNamee EN, Brodsky KS, Ehrentraut SF, Poth JM, Riegel AK, Westrich JA, Colgan SP, Eltzschig HK. CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury. FASEB J. 2013 Jun; 27(6):2207-19. PMID: 23413361.
      View in: PubMed
    104. Colgan SP, Fennimore B, Ehrentraut SF. Adenosine and gastrointestinal inflammation. J Mol Med (Berl). 2013 Feb; 91(2):157-64. PMID: 23296303.
      View in: PubMed
    105. Ehrentraut SF, Kominsky DJ, Glover LE, Campbell EL, Kelly CJ, Bowers BE, Bayless AJ, Colgan SP. Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response. J Immunol. 2013 Jan 01; 190(1):392-400. PMID: 23209320.
      View in: PubMed
    106. Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK. Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol. 2013 Jul; 6(4):762-75. PMID: 23187315.
      View in: PubMed
    107. Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2784-93. PMID: 22988108.
      View in: PubMed
    108. Keely S, Kelly CJ, Weissmueller T, Burgess A, Wagner BD, Robertson CE, Harris JK, Colgan SP. Activated fluid transport regulates bacterial-epithelial interactions and significantly shifts the murine colonic microbiome. Gut Microbes. 2012 May-Jun; 3(3):250-60. PMID: 22614705.
      View in: PubMed
    109. Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP, Eltzschig HK. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med. 2012 Apr 15; 18(5):774-82. PMID: 22504483.
      View in: PubMed
    110. Kelly CJ, Colgan SP, Frank DN. Of microbes and meals: the health consequences of dietary endotoxemia. Nutr Clin Pract. 2012 Apr; 27(2):215-25. PMID: 22378797.
      View in: PubMed
    111. Kelly CJ, Colgan SP. Targeting Hypoxia to Augment Mucosal Barrier Function. J Epithel Biol Pharmacol. 2012; 5(Suppl 1-M10):67-76. PMID: 28824735.
      View in: PubMed
    112. Ehrentraut SF, Colgan SP. Implications of protein post-translational modifications in IBD. Inflamm Bowel Dis. 2012 Jul; 18(7):1378-88. PMID: 22223542.
      View in: PubMed
    113. Colgan SP, Eltzschig HK. Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery. Annu Rev Physiol. 2012; 74:153-75. PMID: 21942704.
      View in: PubMed
    114. Campbell EL, Serhan CN, Colgan SP. Antimicrobial aspects of inflammatory resolution in the mucosa: a role for proresolving mediators. J Immunol. 2011 Oct 01; 187(7):3475-81. PMID: 21934099.
      View in: PubMed
    115. Zemans RL, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, De Langhe S, Reynolds SD, Mason RJ, Kahn M, Henson PM, Colgan SP, Downey GP. Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15990-5. PMID: 21880956.
      View in: PubMed
    116. Glover LE, Colgan SP. Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis. Gastroenterology. 2011 May; 140(6):1748-55. PMID: 21530741.
      View in: PubMed
    117. Kominsky DJ, Keely S, MacManus CF, Glover LE, Scully M, Collins CB, Bowers BE, Campbell EL, Colgan SP. An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. J Immunol. 2011 Jun 01; 186(11):6505-14. PMID: 21515785.
      View in: PubMed
    118. Goldstein JI, Kominsky DJ, Jacobson N, Bowers B, Regalia K, Austin GL, Yousefi M, Falta MT, Fontenot AP, Gerich ME, Golden-Mason L, Colgan SP. Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 2011 Jul; 141(1):208-16. PMID: 21557945.
      View in: PubMed
    119. MacManus CF, Campbell EL, Keely S, Burgess A, Kominsky DJ, Colgan SP. Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization. FASEB J. 2011 Jun; 25(6):1856-64. PMID: 21350119.
      View in: PubMed
    120. Glover LE, Irizarry K, Scully M, Campbell EL, Bowers BE, Aherne CM, Kominsky DJ, MacManus CF, Colgan SP. IFN-? attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1?. J Immunol. 2011 Feb 01; 186(3):1790-8. PMID: 21199896.
      View in: PubMed
    121. Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL. NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis. 2011 Jun; 17(6):1359-72. PMID: 20872834.
      View in: PubMed
    122. Wick MJ, Buesing EJ, Wehling CA, Loomis ZL, Cool CD, Zamora MR, Miller YE, Colgan SP, Hersh LB, Voelkel NF, Dempsey EC. Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011 Feb 01; 183(3):330-40. PMID: 20813891.
      View in: PubMed
    123. Campbell EL, MacManus CF, Kominsky DJ, Keely S, Glover LE, Bowers BE, Scully M, Bruyninckx WJ, Colgan SP. Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14298-303. PMID: 20660763.
      View in: PubMed
    124. Kominsky DJ, Campbell EL, Colgan SP. Metabolic shifts in immunity and inflammation. J Immunol. 2010 Apr 15; 184(8):4062-8. PMID: 20368286.
      View in: PubMed
    125. Colgan SP, Taylor CT. Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol. 2010 May; 7(5):281-7. PMID: 20368740.
      View in: PubMed
    126. Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL. Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterology. 2010 Jul; 139(1):259-69.e3. PMID: 20347817.
      View in: PubMed
    127. Schingnitz U, Hartmann K, Macmanus CF, Eckle T, Zug S, Colgan SP, Eltzschig HK. Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol. 2010 May 01; 184(9):5271-9. PMID: 20348420.
      View in: PubMed
    128. Keely S, Glover LE, Weissmueller T, MacManus CF, Fillon S, Fennimore B, Colgan SP. Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia. Mol Biol Cell. 2010 Feb 15; 21(4):538-46. PMID: 20032301.
      View in: PubMed
    129. Eltzschig HK, Rivera-Nieves J, Colgan SP. Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation. Expert Opin Ther Targets. 2009 Nov; 13(11):1267-77. PMID: 19769545.
      View in: PubMed
    130. Henes J, Schmit MA, Morote-Garcia JC, Mirakaj V, K?hler D, Glover L, Eldh T, Walter U, Karhausen J, Colgan SP, Rosenberger P. Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury. FASEB J. 2009 Dec; 23(12):4244-55. PMID: 19690214.
      View in: PubMed
    131. Ahmad A, Ahmad S, Glover L, Miller SM, Shannon JM, Guo X, Franklin WA, Bridges JP, Schaack JB, Colgan SP, White CW. Adenosine A2A receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10684-9. PMID: 19541651.
      View in: PubMed
    132. Frick JS, MacManus CF, Scully M, Glover LE, Eltzschig HK, Colgan SP. Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol. 2009 Apr 15; 182(8):4957-64. PMID: 19342675.
      View in: PubMed
    133. Liu Q, Li J, Khoury J, Colgan SP, Ibla JC. Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation. J Biol Chem. 2009 May 15; 284(20):13686-13695. PMID: 19297320.
      View in: PubMed
    134. Fillon S, Robinson ZD, Colgan SP, Furuta GT. Epithelial function in eosinophilic gastrointestinal diseases. Immunol Allergy Clin North Am. 2009 Feb; 29(1):171-8, xii-xiii. PMID: 19141352.
      View in: PubMed
    135. Keely S, Glover LE, MacManus CF, Campbell EL, Scully MM, Furuta GT, Colgan SP. Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing. FASEB J. 2009 May; 23(5):1338-46. PMID: 19103643.
      View in: PubMed
    136. Keely S, Ryan SM, Haddleton DM, Limer A, Mantovani G, Murphy EP, Colgan SP, Brayden DJ. Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers. J Control Release. 2009 Apr 02; 135(1):35-43. PMID: 19110018.
      View in: PubMed
    137. Zemans RL, Colgan SP, Downey GP. Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol. 2009 May; 40(5):519-35. PMID: 18978300.
      View in: PubMed
    138. Weissm?ller T, Campbell EL, Rosenberger P, Scully M, Beck PL, Furuta GT, Colgan SP. PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell-expressed ecto-NTPDases. J Clin Invest. 2008 Nov; 118(11):3682-92. PMID: 18924612.
      View in: PubMed
    139. Eltzschig HK, K?hler D, Eckle T, Kong T, Robson SC, Colgan SP. Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood. 2009 Jan 01; 113(1):224-32. PMID: 18812468.
      View in: PubMed
    140. Zheng W, Kuhlicke J, J?ckel K, Eltzschig HK, Singh A, Sj?blom M, Riederer B, Weinhold C, Seidler U, Colgan SP, Karhausen J. Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. FASEB J. 2009 Jan; 23(1):204-13. PMID: 18779379.
      View in: PubMed
    141. Eltzschig HK, Macmanus CF, Colgan SP. Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface. Trends Cardiovasc Med. 2008 Apr; 18(3):103-7. PMID: 18436149.
      View in: PubMed
    142. Louis NA, Robinson AM, MacManus CF, Karhausen J, Scully M, Colgan SP. Control of IFN-alphaA by CD73: implications for mucosal inflammation. J Immunol. 2008 Mar 15; 180(6):4246-55. PMID: 18322237.
      View in: PubMed
    143. Robinson A, Keely S, Karhausen J, Gerich ME, Furuta GT, Colgan SP. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology. 2008 Jan; 134(1):145-55. PMID: 18166352.
      View in: PubMed
    144. Hartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Yazdi AS, Matteoli G, Bohn E, Autenrieth IB, Karhausen J, Neumann D, Colgan SP, Kempf VA. Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. Gastroenterology. 2008 Mar; 134(3):756-67. PMID: 18325389.
      View in: PubMed
    145. Taylor CT, Colgan SP. Hypoxia and gastrointestinal disease. J Mol Med (Berl). 2007 Dec; 85(12):1295-300. PMID: 18026919.
      View in: PubMed
    146. Kong T, Scully M, Shelley CS, Colgan SP. Identification of Pur alpha as a new hypoxia response factor responsible for coordinated induction of the beta 2 integrin family. J Immunol. 2007 Aug 01; 179(3):1934-41. PMID: 17641060.
      View in: PubMed
    147. Campbell EL, Louis NA, Tomassetti SE, Canny GO, Arita M, Serhan CN, Colgan SP. Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J. 2007 Oct; 21(12):3162-70. PMID: 17496159.
      View in: PubMed
    148. Rosenberger P, Khoury J, Kong T, Weissm?ller T, Robinson AM, Colgan SP. Identification of vasodilator-stimulated phosphoprotein (VASP) as an HIF-regulated tissue permeability factor during hypoxia. FASEB J. 2007 Aug; 21(10):2613-21. PMID: 17412998.
      View in: PubMed
    149. Khoury J, Ibla JC, Neish AS, Colgan SP. Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. J Clin Invest. 2007 Mar; 117(3):703-11. PMID: 17318263.
      View in: PubMed
    150. Sun YP, Oh SF, Uddin J, Yang R, Gotlinger K, Campbell E, Colgan SP, Petasis NA, Serhan CN. Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30; 282(13):9323-9334. PMID: 17244615.
      View in: PubMed
    151. Louis NA, Campbell E, Colgan SP. Model systems to investigate neutrophil adhesion and chemotaxis. Methods Mol Biol. 2007; 412:257-70. PMID: 18453117.
      View in: PubMed
    152. Louis NA, Hamilton KE, Canny G, Shekels LL, Ho SB, Colgan SP. Selective induction of mucin-3 by hypoxia in intestinal epithelia. J Cell Biochem. 2006 Dec 15; 99(6):1616-27. PMID: 16823775.
      View in: PubMed
    153. Kong T, Westerman KA, Faigle M, Eltzschig HK, Colgan SP. HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J. 2006 Nov; 20(13):2242-50. PMID: 17077301.
      View in: PubMed
    154. Eltzschig HK, Eckle T, Mager A, K?per N, Karcher C, Weissm?ller T, Boengler K, Schulz R, Robson SC, Colgan SP. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res. 2006 Nov 10; 99(10):1100-8. PMID: 17038639.
      View in: PubMed
    155. Patel NJ, Zaborina O, Wu L, Wang Y, Wolfgeher DJ, Valuckaite V, Ciancio MJ, Kohler JE, Shevchenko O, Colgan SP, Chang EB, Turner JR, Alverdy JC. Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G134-42. PMID: 16901993.
      View in: PubMed
    156. Canny GO, Trifonova RT, Kindelberger DW, Colgan SP, Fichorova RN. Expression and function of bactericidal/permeability-increasing protein in human genital tract epithelial cells. J Infect Dis. 2006 Aug 15; 194(4):498-502. PMID: 16845634.
      View in: PubMed
    157. Costa C, Zhao L, Shen Y, Su X, Hao L, Colgan SP, Stahl GL, Zhou T, Wang Y. Role of complement component C5 in cerebral ischemia/reperfusion injury. Brain Res. 2006 Jul 19; 1100(1):142-51. PMID: 16780818.
      View in: PubMed
    158. Colgan SP, Eltzschig HK, Eckle T, Thompson LF. Physiological roles for ecto-5'-nucleotidase (CD73). Purinergic Signal. 2006 Jun; 2(2):351-60. PMID: 18404475.
      View in: PubMed
    159. Eltzschig HK, Faigle M, Knapp S, Karhausen J, Ibla J, Rosenberger P, Odegard KC, Laussen PC, Thompson LF, Colgan SP. Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood. 2006 Sep 01; 108(5):1602-10. PMID: 16670267.
      View in: PubMed
    160. Ibla JC, Khoury J, Kong T, Robinson A, Colgan SP. Transcriptional repression of Na-K-2Cl cotransporter NKCC1 by hypoxia-inducible factor-1. Am J Physiol Cell Physiol. 2006 Aug; 291(2):C282-9. PMID: 16571862.
      View in: PubMed
    161. Serhan CN, Gotlinger K, Hong S, Lu Y, Siegelman J, Baer T, Yang R, Colgan SP, Petasis NA. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. J Immunol. 2006 Feb 01; 176(3):1848-59. PMID: 16424216.
      View in: PubMed
    162. Louis NA, Daniels D, Colgan SP. Cell-cell interactions on solid matrices. Methods Mol Biol. 2006; 341:51-9. PMID: 16799188.
      View in: PubMed
    163. Eltzschig HK, Abdulla P, Hoffman E, Hamilton KE, Daniels D, Sch?nfeld C, L?ffler M, Reyes G, Duszenko M, Karhausen J, Robinson A, Westerman KA, Coe IR, Colgan SP. HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J Exp Med. 2005 Dec 05; 202(11):1493-505. PMID: 16330813.
      View in: PubMed
    164. Canny G, Cario E, Lennartsson A, Gullberg U, Brennan C, Levy O, Colgan SP. Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein. Am J Physiol Gastrointest Liver Physiol. 2006 Mar; 290(3):G557-67. PMID: 16282362.
      View in: PubMed
    165. Louis NA, Hamilton KE, Colgan SP. Lipid mediator networks and leukocyte transmigration. Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct; 73(3-4):197-202. PMID: 15979294.
      View in: PubMed
    166. Karhausen J, Kong T, Narravula S, Colgan SP. Induction of the von Hippel-Lindau tumor suppressor gene by late hypoxia limits HIF-1 expression. J Cell Biochem. 2005 Aug 15; 95(6):1264-75. PMID: 15962286.
      View in: PubMed
    167. Weissmuller T, Eltzschig HK, Colgan SP. Dynamic purine signaling and metabolism during neutrophil-endothelial interactions. Purinergic Signal. 2005 Sep; 1(3):229-39. PMID: 18404508.
      View in: PubMed
    168. Louis NA, Hamilton KE, Kong T, Colgan SP. HIF-dependent induction of apical CD55 coordinates epithelial clearance of neutrophils. FASEB J. 2005 Jun; 19(8):950-9. PMID: 15923405.
      View in: PubMed
    169. Canny G, Colgan SP. Events at the host-microbial interface of the gastrointestinal tract. I. Adaptation to a microbial world: role of epithelial bactericidal/permeability-increasing protein. Am J Physiol Gastrointest Liver Physiol. 2005 Apr; 288(4):G593-7. PMID: 15764808.
      View in: PubMed
    170. Blumberg RS, Pitman RS, Taylor CT, Colgan SP. Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alpha. J Interferon Cytokine Res. 2005 Apr; 25(4):209-19. PMID: 15812247.
      View in: PubMed
    171. Karhausen J, Haase VH, Colgan SP. Inflammatory hypoxia: role of hypoxia-inducible factor. Cell Cycle. 2005 Feb; 4(2):256-8. PMID: 15655360.
      View in: PubMed
    172. Thompson LF, Eltzschig HK, Ibla JC, Van De Wiele CJ, Resta R, Morote-Garcia JC, Colgan SP. Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med. 2004 Dec 06; 200(11):1395-405. PMID: 15583013.
      View in: PubMed
    173. Kaser A, Nieuwenhuis EE, Strober W, Mayer L, Fuss I, Colgan S, Blumberg RS. Natural killer T cells in mucosal homeostasis. Ann N Y Acad Sci. 2004 Dec; 1029:154-68. PMID: 15681754.
      View in: PubMed
    174. Karhausen J, Furuta GT, Tomaszewski JE, Johnson RS, Colgan SP, Haase VH. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest. 2004 Oct; 114(8):1098-106. PMID: 15489957.
      View in: PubMed
    175. Eltzschig HK, Thompson LF, Karhausen J, Cotta RJ, Ibla JC, Robson SC, Colgan SP. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood. 2004 Dec 15; 104(13):3986-92. PMID: 15319286.
      View in: PubMed
    176. Kong T, Eltzschig HK, Karhausen J, Colgan SP, Shelley CS. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10440-5. PMID: 15235127.
      View in: PubMed
    177. Kaser A, Nieuwenhuis EE, Strober W, Fuss I, Colgan S, Blumberg RS. CD1d-restricted T cell pathways at the epithelial-lymphocyte-luminal interface. J Pediatr Gastroenterol Nutr. 2004 Jun; 39 Suppl 3:S719-22. PMID: 15167359.
      View in: PubMed
    178. Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, Chen D, Kaser A, Glickman J, Kuo T, Little A, Morrison J, Corazza N, Kim JY, Colgan SP, Young SG, Exley M, Blumberg RS. CD1d function is regulated by microsomal triglyceride transfer protein. Nat Med. 2004 May; 10(5):535-9. PMID: 15107843.
      View in: PubMed
    179. Gronert K, Kantarci A, Levy BD, Clish CB, Odparlik S, Hasturk H, Badwey JA, Colgan SP, Van Dyke TE, Serhan CN. A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage. J Immunol. 2004 Feb 01; 172(3):1856-61. PMID: 14734770.
      View in: PubMed
    180. Comerford KM, Colgan SP. Assessing oxygen sensitivity of the multidrug resistance (MDR) gene. Methods Enzymol. 2004; 381:376-87. PMID: 15063687.
      View in: PubMed
    181. Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, Colgan SP, Stahl GL, Merched A, Petasis NA, Chan L, Van Dyke TE. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol. 2003 Dec 15; 171(12):6856-65. PMID: 14662892.
      View in: PubMed
    182. Lawrence DW, Bruyninckx WJ, Louis NA, Lublin DM, Stahl GL, Parkos CA, Colgan SP. Antiadhesive role of apical decay-accelerating factor (CD55) in human neutrophil transmigration across mucosal epithelia. J Exp Med. 2003 Oct 06; 198(7):999-1010. PMID: 14530374.
      View in: PubMed
    183. Colgan SP, Pitman RS, Nagaishi T, Mizoguchi A, Mizoguchi E, Mayer LF, Shao L, Sartor RB, Subjeck JR, Blumberg RS. Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells. J Clin Invest. 2003 Sep; 112(5):745-54. PMID: 12952923.
      View in: PubMed
    184. Eltzschig HK, Ibla JC, Furuta GT, Leonard MO, Jacobson KA, Enjyoji K, Robson SC, Colgan SP. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med. 2003 Sep 01; 198(5):783-96. PMID: 12939345.
      View in: PubMed
    185. Levy O, Canny G, Serhan CN, Colgan SP. Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia. Biochem Soc Trans. 2003 Aug; 31(Pt 4):795-800. PMID: 12887308.
      View in: PubMed
    186. van de Wal Y, Corazza N, Allez M, Mayer LF, Iijima H, Ryan M, Cornwall S, Kaiserlian D, Hershberg R, Koezuka Y, Colgan SP, Blumberg RS. Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells. Gastroenterology. 2003 May; 124(5):1420-31. PMID: 12730881.
      View in: PubMed
    187. Fierro IM, Colgan SP, Bernasconi G, Petasis NA, Clish CB, Arita M, Serhan CN. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells. J Immunol. 2003 Mar 01; 170(5):2688-94. PMID: 12594298.
      View in: PubMed
    188. Karhausen J, Ibla JC, Colgan SP. Implications of hypoxia on mucosal barrier function. Cell Mol Biol (Noisy-le-grand). 2003 Feb; 49(1):77-87. PMID: 12839339.
      View in: PubMed
    189. Comerford KM, Leonard MO, Karhausen J, Carey R, Colgan SP, Taylor CT. Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):986-91. PMID: 12552083.
      View in: PubMed
    190. Schottelius AJ, Giesen C, Asadullah K, Fierro IM, Colgan SP, Bauman J, Guilford W, Perez HD, Parkinson JF. An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile. J Immunol. 2002 Dec 15; 169(12):7063-70. PMID: 12471142.
      View in: PubMed
    191. Lawrence DW, Comerford KM, Colgan SP. Role of VASP in reestablishment of epithelial tight junction assembly after Ca2+ switch. Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1235-45. PMID: 11997237.
      View in: PubMed
    192. Nieuwenhuis EE, Matsumoto T, Exley M, Schleipman RA, Glickman J, Bailey DT, Corazza N, Colgan SP, Onderdonk AB, Blumberg RS. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med. 2002 Jun; 8(6):588-93. PMID: 12042809.
      View in: PubMed
    193. Colgan SP. Lipid mediators in epithelial cell-cell interactions. Cell Mol Life Sci. 2002 May; 59(5):754-60. PMID: 12088276.
      View in: PubMed
    194. Comerford KM, Lawrence DW, Synnestvedt K, Levi BP, Colgan SP. Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability. FASEB J. 2002 Apr; 16(6):583-5. PMID: 11919161.
      View in: PubMed
    195. Canny G, Levy O, Furuta GT, Narravula-Alipati S, Sisson RB, Serhan CN, Colgan SP. Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3902-7. PMID: 11891303.
      View in: PubMed
    196. Colgan SP, Comerford KM, Lawrence DW. Epithelial cell-neutrophil interactions in the alimentary tract: a complex dialog in mucosal surveillance and inflammation. ScientificWorldJournal. 2002 Jan 09; 2:76-88. PMID: 12806040.
      View in: PubMed
    197. Colgan SP, Taylor CT, Narravula S, Synnestvedt K, Blume ED. Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1 alpha, a potent epithelial secretagogue. Adv Exp Med Biol. 2002; 507:107-12. PMID: 12664572.
      View in: PubMed
    198. Brand S, Sakaguchi T, Gu X, Colgan SP, Reinecker HC. Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells. Gastroenterology. 2002 Jan; 122(1):166-77. PMID: 11781291.
      View in: PubMed
    199. Bruyninckx WJ, Comerford KM, Lawrence DW, Colgan SP. Phosphoinositide 3-kinase modulation of beta(3)-integrin represents an endogenous "braking" mechanism during neutrophil transmatrix migration. Blood. 2001 May 15; 97(10):3251-8. PMID: 11342456.
      View in: PubMed
    200. Furuta GT, Turner JR, Taylor CT, Hershberg RM, Comerford K, Narravula S, Podolsky DK, Colgan SP. Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J Exp Med. 2001 May 07; 193(9):1027-34. PMID: 11342587.
      View in: PubMed
    201. Reaves TA, Colgan SP, Selvaraj P, Pochet MM, Walsh S, Nusrat A, Liang TW, Madara JL, Parkos CA. Neutrophil transepithelial migration: regulation at the apical epithelial surface by Fc-mediated events. Am J Physiol Gastrointest Liver Physiol. 2001 Apr; 280(4):G746-54. PMID: 11254502.
      View in: PubMed
    202. Narravula S, Lennon PF, Mueller BU, Colgan SP. Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier function. J Immunol. 2000 Nov 01; 165(9):5262-8. PMID: 11046060.
      View in: PubMed
    203. Taylor CT, Furuta GT, Synnestvedt K, Colgan SP. Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12091-6. PMID: 11035795.
      View in: PubMed
    204. Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert K. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J Exp Med. 2000 Oct 16; 192(8):1197-204. PMID: 11034610.
      View in: PubMed
    205. Kim HS, Colgan SP, Pitman R, Hershberg RM, Blumberg RS. Human CD1d associates with prolyl-4-hydroxylase during its biosynthesis. Mol Immunol. 2000 Oct; 37(14):861-8. PMID: 11257307.
      View in: PubMed
    206. Furuta GT, Dzus AL, Taylor CT, Colgan SP. Parallel induction of epithelial surface-associated chemokine and proteoglycan by cellular hypoxia: implications for neutrophil activation. J Leukoc Biol. 2000 Aug; 68(2):251-9. PMID: 10947070.
      View in: PubMed
    207. Colgan SP, Hershberg RM, Furuta GT, Blumberg RS. Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13938-43. PMID: 10570177.
      View in: PubMed
    208. Taylor CT, Colgan SP. Therapeutic targets for hypoxia-elicited pathways. Pharm Res. 1999 Oct; 16(10):1498-505. PMID: 10554089.
      View in: PubMed
    209. Taylor CT, Fueki N, Agah A, Hershberg RM, Colgan SP. Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-alpha. J Biol Chem. 1999 Jul 02; 274(27):19447-54. PMID: 10383461.
      View in: PubMed
    210. Blumberg RS, Lencer WI, Zhu X, Kim HS, Claypool S, Balk SP, Saubermann LJ, Colgan SP. Antigen presentation by intestinal epithelial cells. Immunol Lett. 1999 Jun 15; 69(1):7-11. PMID: 10436875.
      View in: PubMed
    211. Somnay-Wadgaonkar K, Nusrat A, Kim HS, Canchis WP, Balk SP, Colgan SP, Blumberg RS. Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form. Int Immunol. 1999 Mar; 11(3):383-92. PMID: 10221650.
      View in: PubMed
    212. Collard CD, Bukusoglu C, Agah A, Colgan SP, Reenstra WR, Morgan BP, Stahl GL. Hypoxia-induced expression of complement receptor type 1 (CR1, CD35) in human vascular endothelial cells. Am J Physiol. 1999 02; 276(2):C450-8. PMID: 9950773.
      View in: PubMed
    213. Lennon PF, Taylor CT, Stahl GL, Colgan SP. Neutrophil-derived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation. J Exp Med. 1998 Oct 19; 188(8):1433-43. PMID: 9782120.
      View in: PubMed
    214. Blume ED, Taylor CT, Lennon PF, Stahl GL, Colgan SP. Activated endothelial cells elicit paracrine induction of epithelial chloride secretion. 6-Keto-PGF1alpha is an epithelial secretagogue. J Clin Invest. 1998 Sep 15; 102(6):1161-72. PMID: 9739050.
      View in: PubMed
    215. Friedman GB, Taylor CT, Parkos CA, Colgan SP. Epithelial permeability induced by neutrophil transmigration is potentiated by hypoxia: role of intracellular cAMP. J Cell Physiol. 1998 Jul; 176(1):76-84. PMID: 9618147.
      View in: PubMed
    216. Taylor CT, Dzus AL, Colgan SP. Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha. Gastroenterology. 1998 Apr; 114(4):657-68. PMID: 9516386.
      View in: PubMed
    217. Maddox JF, Colgan SP, Clish CB, Petasis NA, Fokin VV, Serhan CN. Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity. FASEB J. 1998 Apr; 12(6):487-94. PMID: 9535221.
      View in: PubMed
    218. Gronert K, Colgan SP, Serhan CN. Characterization of human neutrophil and endothelial cell ligand-operated extracellular acidification rate by microphysiometry: impact of reoxygenation. J Pharmacol Exp Ther. 1998 Apr; 285(1):252-61. PMID: 9536019.
      View in: PubMed
    219. Colgan SP. Nitric oxide and intestinal epithelia: just say NO. Gastroenterology. 1998 Mar; 114(3):601-3. PMID: 9496953.
      View in: PubMed
    220. Taylor CT, Lisco SJ, Awtrey CS, Colgan SP. Hypoxia inhibits cyclic nucleotide-stimulated epithelial ion transport: role for nucleotide cyclases as oxygen sensors. J Pharmacol Exp Ther. 1998 Feb; 284(2):568-75. PMID: 9454799.
      View in: PubMed
    221. McCormick BA, Parkos CA, Colgan SP, Carnes DK, Madara JL. Apical secretion of a pathogen-elicited epithelial chemoattractant activity in response to surface colonization of intestinal epithelia by Salmonella typhimurium. J Immunol. 1998 Jan 01; 160(1):455-66. PMID: 9552004.
      View in: PubMed
    222. Z?nd G, Uezono S, Stahl GL, Dzus AL, McGowan FX, Hickey PR, Colgan SP. Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes. Am J Physiol. 1997 11; 273(5):C1571-80. PMID: 9374642.
      View in: PubMed
    223. Christ AD, Colgan SP, Balk SP, Blumberg RS. Human intestinal epithelial cell lines produce factor(s) that inhibit CD3-mediated T-lymphocyte proliferation. Immunol Lett. 1997 Aug; 58(3):159-65. PMID: 9293397.
      View in: PubMed
    224. Blumberg RS, Colgan SP, Balk SP. CD1d: outside-in antigen presentation in the intestinal epithelium? Clin Exp Immunol. 1997 Aug; 109(2):223-5. PMID: 9276515.
      View in: PubMed
    225. Collard CD, V?kev? A, B?k?soglu C, Z?nd G, Sperati CJ, Colgan SP, Stahl GL. Reoxygenation of hypoxic human umbilical vein endothelial cells activates the classic complement pathway. Circulation. 1997 Jul 01; 96(1):326-33. PMID: 9236453.
      View in: PubMed
    226. Colgan SP, Dzus AL, Parkos CA. Epithelial exposure to hypoxia modulates neutrophil transepithelial migration. J Exp Med. 1996 Sep 01; 184(3):1003-15. PMID: 9064318.
      View in: PubMed
    227. Z?nd G, Nelson DP, Neufeld EJ, Dzus AL, Bischoff J, Mayer JE, Colgan SP. Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells. Proc Natl Acad Sci U S A. 1996 Jul 09; 93(14):7075-80. PMID: 8692947.
      View in: PubMed
    228. Parkos CA, Colgan SP, Diamond MS, Nusrat A, Liang TW, Springer TA, Madara JL. Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: consequences for CD11b/CD18-mediated interactions with neutrophils. Mol Med. 1996 Jul; 2(4):489-505. PMID: 8827719.
      View in: PubMed
    229. Colgan SP, Morales VM, Madara JL, Polischuk JE, Balk SP, Blumberg RS. IFN-gamma modulates CD1d surface expression on intestinal epithelia. Am J Physiol. 1996 Jul; 271(1 Pt 1):C276-83. PMID: 8760056.
      View in: PubMed
    230. Hofman P, D'Andrea L, Carnes D, Colgan SP, Madara JL. Intestinal epithelial cytoskeleton selectively constrains lumen-to-tissue migration of neutrophils. Am J Physiol. 1996 Jul; 271(1 Pt 1):C312-20. PMID: 8760060.
      View in: PubMed
    231. Z?nd G, Madara JL, Dzus AL, Awtrey CS, Colgan SP. Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion. J Biol Chem. 1996 Mar 29; 271(13):7460-4. PMID: 8631774.
      View in: PubMed
    232. Parkos CA, Colgan SP, Liang TW, Nusrat A, Bacarra AE, Carnes DK, Madara JL. CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia. J Cell Biol. 1996 Feb; 132(3):437-50. PMID: 8636220.
      View in: PubMed
    233. Z?nd G, Dzus AL, McGuirk DK, Breuer C, Shinoka T, Mayer JE, Colgan SP. Hypoxic stress alone does not modulate endothelial surface expression of bovine E-selectin and intercellular adhesion molecule-1 (ICAM-1). Swiss Surg Suppl. 1996; Suppl 1:41-5. PMID: 8653575.
      View in: PubMed
    234. Nusrat A, Giry M, Turner JR, Colgan SP, Parkos CA, Carnes D, Lemichez E, Boquet P, Madara JL. Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia. Proc Natl Acad Sci U S A. 1995 Nov 07; 92(23):10629-33. PMID: 7479854.
      View in: PubMed
    235. Serhan CN, Maddox JF, Petasis NA, Akritopoulou-Zanze I, Papayianni A, Brady HR, Colgan SP, Madara JL. Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry. 1995 Nov 07; 34(44):14609-15. PMID: 7578068.
      View in: PubMed
    236. Colgan SP, Parkos CA, McGuirk D, Brady HR, Papayianni AA, Frendl G, Madara JL. Receptors involved in carbohydrate binding modulate intestinal epithelial-neutrophil interactions. J Biol Chem. 1995 May 05; 270(18):10531-9. PMID: 7537733.
      View in: PubMed
    237. Parkos CA, Colgan SP, Bacarra AE, Nusrat A, Delp-Archer C, Carlson S, Su DH, Madara JL. Intestinal epithelia (T84) possess basolateral ligands for CD11b/CD18-mediated neutrophil adherence. Am J Physiol. 1995 Feb; 268(2 Pt 1):C472-9. PMID: 7532360.
      View in: PubMed
    238. Resnick MB, Colgan SP, Parkos CA, Delp-Archer C, McGuirk D, Weller PF, Madara JL. Human eosinophils migrate across an intestinal epithelium in response to platelet-activating factor. Gastroenterology. 1995 Feb; 108(2):409-16. PMID: 7835581.
      View in: PubMed
    239. Sanders SE, Madara JL, McGuirk DK, Gelman DS, Colgan SP. Assessment of inflammatory events in epithelial permeability: a rapid screening method using fluorescein dextrans. Epithelial Cell Biol. 1995; 4(1):25-34. PMID: 8563793.
      View in: PubMed
    240. Colgan SP, Resnick MB, Parkos CA, Delp-Archer C, McGuirk D, Bacarra AE, Weller PF, Madara JL. IL-4 directly modulates function of a model human intestinal epithelium. J Immunol. 1994 Sep 01; 153(5):2122-9. PMID: 7914217.
      View in: PubMed
    241. Parkos CA, Colgan SP, Madara JL. Interactions of neutrophils with epithelial cells: lessons from the intestine. J Am Soc Nephrol. 1994 Aug; 5(2):138-52. PMID: 7993993.
      View in: PubMed
    242. Kaoutzani P, Colgan SP, Cepek KL, Burkard PG, Carlson S, Delp-Archer C, Brenner MB, Madara JL. Reconstitution of cultured intestinal epithelial monolayers with a mucosal-derived T lymphocyte cell line. Modulation of epithelial phenotype dependent on lymphocyte-basolateral membrane apposition. J Clin Invest. 1994 Aug; 94(2):788-96. PMID: 8040334.
      View in: PubMed
    243. Colgan SP, Parkos CA, Matthews JB, D'Andrea L, Awtrey CS, Lichtman AH, Delp-Archer C, Madara JL. Interferon-gamma induces a cell surface phenotype switch on T84 intestinal epithelial cells. Am J Physiol. 1994 Aug; 267(2 Pt 1):C402-10. PMID: 8074176.
      View in: PubMed
    244. Balk SP, Burke S, Polischuk JE, Frantz ME, Yang L, Porcelli S, Colgan SP, Blumberg RS. Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. Science. 1994 Jul 08; 265(5169):259-62. PMID: 7517575.
      View in: PubMed
    245. Resnick MB, Colgan SP, Patapoff TW, Mrsny RJ, Awtrey CS, Delp-Archer C, Weller PF, Madara JL. Activated eosinophils evoke chloride secretion in model intestinal epithelia primarily via regulated release of 5'-AMP. J Immunol. 1993 Nov 15; 151(10):5716-23. PMID: 8228257.
      View in: PubMed
    246. McCormick BA, Colgan SP, Delp-Archer C, Miller SI, Madara JL. Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils. J Cell Biol. 1993 Nov; 123(4):895-907. PMID: 8227148.
      View in: PubMed
    247. Colgan SP, Serhan CN, Parkos CA, Delp-Archer C, Madara JL. Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers. J Clin Invest. 1993 Jul; 92(1):75-82. PMID: 8326019.
      View in: PubMed
    248. Madara JL, Patapoff TW, Gillece-Castro B, Colgan SP, Parkos CA, Delp C, Mrsny RJ. 5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers. J Clin Invest. 1993 May; 91(5):2320-5. PMID: 8486793.
      View in: PubMed
    249. Colgan SP, Parkos CA, Delp C, Arnaout MA, Madara JL. Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion. J Cell Biol. 1993 Feb; 120(3):785-98. PMID: 8093887.
      View in: PubMed
    250. Colgan SP, Gasper PW, Thrall MA, Boone TC, Blancquaert AM, Bruyninckx WJ. Neutrophil function in normal and Chediak-Higashi syndrome cats following administration of recombinant canine granulocyte colony-stimulating factor. Exp Hematol. 1992 Nov; 20(10):1229-34. PMID: 1385198.
      View in: PubMed
    251. Grauer GF, Rose BJ, Toolan L, Thrall MA, Colgan SP. Effects of low-dose aspirin and specific thromboxane synthetase inhibition on whole blood platelet aggregation and adenosine triphosphate secretion in healthy dogs. Am J Vet Res. 1992 Sep; 53(9):1631-5. PMID: 1416368.
      View in: PubMed
    252. Colgan SP, Matthews JB, Parkos CA, Delp C, Awtrey CS, Madara JL. The myeloid leukemia cell line HL-60 produces a factor that induces chloride secretion in cultured epithelial cells. J Leukoc Biol. 1992 Aug; 52(2):183-7. PMID: 1506774.
      View in: PubMed
    253. Madara JL, Parkos C, Colgan S, MacLeod RJ, Nash S, Matthews J, Delp C, Lencer W. Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue. J Clin Invest. 1992 Jun; 89(6):1938-44. PMID: 1602001.
      View in: PubMed
    254. Parkos CA, Colgan SP, Delp C, Arnaout MA, Madara JL. Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways. J Cell Biol. 1992 May; 117(4):757-64. PMID: 1577855.
      View in: PubMed
    255. Colgan SP, Blancquaert AM, Thrall MA, Bruyninckx WJ. Defective in vitro motility of polymorphonuclear leukocytes of homozygote and heterozygote Chediak-Higashi cats. Vet Immunol Immunopathol. 1992 Mar; 31(3-4):205-27. PMID: 1589952.
      View in: PubMed
    256. Madara JL, Parkos C, Colgan S, Nusrat A, Atisook K, Kaoutzani P. The movement of solutes and cells across tight junctions. Ann N Y Acad Sci. 1992; 664:47-60. PMID: 1456668.
      View in: PubMed
    257. Colgan SP, Hull-Thrall MA, Gasper PW, Gould DH, Rose BJ, Fulton R, Blanquaert AM, Bruyninckx WJ. Restoration of neutrophil and platelet function in feline Chediak-Higashi syndrome by bone marrow transplantation. Bone Marrow Transplant. 1991 May; 7(5):365-74. PMID: 2070146.
      View in: PubMed
    258. Reagan WJ, Garry F, Thrall MA, Colgan S, Hutchison J, Weiser MG. The clinicopathologic, light, and scanning electron microscopic features of eperythrozoonosis in four naturally infected llamas. Vet Pathol. 1990 Nov; 27(6):426-31. PMID: 2278130.
      View in: PubMed
    259. Blancquaert AB, Colgan SP, Bruyninckx WJ. Influence of technical parameters on the in vitro motility of equine neutrophils in the presence of streptococcal culture supernatant. Vet Immunol Immunopathol. 1989 Nov 30; 23(1-2):85-101. PMID: 2515650.
      View in: PubMed
    260. Colgan SP, Hull Thrall MA, Gasper PW. Platelet aggregation and ATP secretion in whole blood of normal cats and cats homozygous and heterozygous for Chediak-Higashi syndrome. Blood Cells. 1989; 15(3):585-95; discussion 596-600. PMID: 2620102.
      View in: PubMed
    261. Blancquaert AM, Colgan SP, Bruyninckx WJ. Chemotactic and chemokinetic activity of Streptococcus faecalis culture supernatant for equine neutrophils. Vet Immunol Immunopathol. 1988 Oct; 19(3-4):285-97. PMID: 3150886.
      View in: PubMed
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