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Sean P Colgan

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    T32DK007038     (ROSEN, HUGO RAMON)Jul 1, 1975 - Jun 30, 2021
    NIH/NIDDK
    Gastrointestinal Diseases Training Grant
    Role: Co-Principal Investigator

    P30DK034854     (LENCER, WAYNE I)Sep 30, 1984 - Nov 30, 2020
    NIH/NIDDK
    Integrated Epithelial and Mucosal Biology
    Role: Co-Principal Investigator

    F32DK008777     (COLGAN, SEAN P)Feb 10, 1993
    NIH/NIDDK
    CYTOKINE EFFECTS ON INTESTINAL INFLAMMATION
    Role: Principal Investigator

    R29DK050189     (COLGAN, SEAN P)Sep 25, 1995 - Aug 31, 2000
    NIH/NIDDK
    EPITHELIA AND ISCHEMIA/REPERFUSION INJURY
    Role: Principal Investigator

    R01DK050189     (COLGAN, SEAN P)Sep 25, 1995 - Jan 31, 2011
    NIH/NIDDK
    Role of Epithelia In Ischemia Reperfusion Injury
    Role: Principal Investigator

    R37DK050189     (COLGAN, SEAN P)Sep 25, 1995 - Jun 30, 2020
    NIH/NIDDK
    Hypoxia, HIF, and Mucosal Inflammation
    Role: Principal Investigator

    R01HL060569     (COLGAN, SEAN P)Apr 1, 1999 - Feb 28, 2015
    NIH/NHLBI
    Hypoxia and Inflammation at the Vascular Interface
    Role: Principal Investigator

    R21DK065768     (COLGAN, SEAN P)Jun 1, 2004 - May 31, 2007
    NIH/NIDDK
    Epithelial BPI and intestinal inflammation
    Role: Principal Investigator

    R13DK093264     (WU, GARY D.)Aug 1, 2011 - Jul 31, 2012
    NIH/NIDDK
    FASEB SRC on Gastrointestinal Tract XIV: Stem Cells, Adaptation, Inflammation and
    Role: Co-Principal Investigator

    R01DK095491     (COLGAN, SEAN P)Jun 1, 2012 - May 31, 2020
    NIH/NIDDK
    Mechanisms of Adenosine Protection
    Role: Principal Investigator

    I01BX002182     (COLGAN, SEAN P)Apr 1, 2014 - Mar 31, 2018
    VA
    Metabolic Regulation of Mucosal Inflammation
    Role: Principal Investigator

    R01DK104713     (COLGAN, SEAN P)Apr 1, 2015 - Mar 31, 2020
    NIH/NIDDK
    METABOLIC REGULATION OF INFLAMMATION BY MICROBIAL-DERIVED SHORT CHAIN FATTY ACIDS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang RX, Colgan SP. Special pro-resolving mediator (SPM) actions in regulating gastro-intestinal inflammation and gut mucosal immune responses. Mol Aspects Med. 2017 Feb 21. PMID: 28232096.
      View in: PubMed
    2. Ehrentraut SF, Curtis VF, Wang RX, Saeedi BJ, Ehrentraut H, Onyiah JC, Kelly CJ, Campbell EL, Glover LE, Kominsky DJ, Colgan SP. Perturbation of neddylation-dependent NF-?B responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation. Mol Biol Cell. 2016 Sep 28. PMID: 27682585.
      View in: PubMed
    3. Kitzenberg D, Colgan SP, Glover LE. Creatine kinase in ischemic and inflammatory disorders. Clin Transl Med. 2016 Dec; 5(1):31. PMID: 27527620; PMCID: PMC4987751.
    4. Glover LE, Lee JS, Colgan SP. Oxygen metabolism and barrier regulation in the intestinal mucosa. J Clin Invest. 2016 Oct 03; 126(10):3680-3688. PMID: 27500494.
      View in: PubMed
    5. Frasch SC, McNamee EN, Kominsky D, Jedlicka P, Jakubzick C, Zemski Berry K, Mack M, Furuta GT, Lee JJ, Henson PM, Colgan SP, Bratton DL. G2A Signaling Dampens Colitic Inflammation via Production of IFN-?. J Immunol. 2016 Aug 15; 197(4):1425-34. PMID: 27402702; PMCID: PMC4975950 [Available on 08/15/17].
    6. Colgan SP, Campbell EL, Kominsky DJ. Hypoxia and Mucosal Inflammation. Annu Rev Pathol. 2016 May 23; 11:77-100. PMID: 27193451.
      View in: PubMed
    7. Ju C, Colgan SP, Eltzschig HK. Hypoxia-inducible factors as molecular targets for liver diseases. J Mol Med (Berl). 2016 Jun; 94(6):613-27. PMID: 27094811; PMCID: PMC4879168.
    8. Kelly CJ, Colgan SP. Breathless in the Gut: Implications of Luminal O2 for Microbial Pathogenicity. Cell Host Microbe. 2016 Apr 13; 19(4):427-8. PMID: 27078062.
      View in: PubMed
    9. Fu Q, Colgan SP, Shelley CS. Hypoxia: The Force that Drives Chronic Kidney Disease. Clin Med Res. 2016 Mar; 14(1):15-39. PMID: 26847481; PMCID: PMC4851450.
    10. Colgan SP. Targeting hypoxia in inflammatory bowel disease. J Investig Med. 2016 Feb; 64(2):364-8. PMID: 26098381; PMCID: PMC4684799 [Available on 02/01/17].
    11. Zheng L, Kelly CJ, Colgan SP. Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia. Am J Physiol Cell Physiol. 2015 Sep 15; 309(6):C350-60. PMID: 26179603; PMCID: PMC4572369.
    12. Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Erratum: Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 May; 8(3):699. PMID: 25943416.
      View in: PubMed
    13. Kelly CJ, Zheng L, Campbell EL, Saeedi B, Scholz CC, Bayless AJ, Wilson KE, Glover LE, Kominsky DJ, Magnuson A, Weir TL, Ehrentraut SF, Pickel C, Kuhn KA, Lanis JM, Nguyen V, Taylor CT, Colgan SP. Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. Cell Host Microbe. 2015 May 13; 17(5):662-71. PMID: 25865369; PMCID: PMC4433427.
    14. Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 Nov; 8(6):1324-38. PMID: 25850656; PMCID: PMC4598274.
    15. Colgan SP, Curtis VF, Lanis JM, Glover LE. Metabolic regulation of intestinal epithelial barrier during inflammation. Tissue Barriers. 2015; 3(1-2):e970936. PMID: 25838978; PMCID: PMC4372015.
    16. Colgan SP. Neutrophils and inflammatory resolution in the mucosa. Semin Immunol. 2015 May; 27(3):177-83. PMID: 25818531; PMCID: PMC4515383.
    17. Campbell EL, Colgan SP. Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa. J Leukoc Biol. 2015 Oct; 98(4):517-22. PMID: 25714801; PMCID: PMC4569047 [Available on 10/01/16].
    18. Xiong W, Knox AJ, Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME. Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. Mol Endocrinol. 2015 Mar; 29(3):460-72. PMID: 25650755; PMCID: PMC4580653.
    19. Eltzschig HK, Bratton DL, Colgan SP. Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases. Nat Rev Drug Discov. 2014 Nov; 13(11):852-69. PMID: 25359381; PMCID: PMC4259899.
    20. Curtis VF, Ehrentraut SF, Campbell EL, Glover LE, Bayless A, Kelly CJ, Kominsky DJ, Colgan SP. Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. FASEB J. 2015 Jan; 29(1):208-15. PMID: 25326537; PMCID: PMC4285538.
    21. Curtis VF, Ehrentraut SF, Colgan SP. Actions of adenosine on cullin neddylation: implications for inflammatory responses. Comput Struct Biotechnol J. 2015; 13:273-6. PMID: 25973141; PMCID: PMC4423527.
    22. Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT. Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis. Gut. 2015 Aug; 64(8):1236-47. PMID: 25209655; PMCID: PMC4515997.
    23. Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L, Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, Colgan SP. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 2014 Jan 16; 40(1):66-77. PMID: 24412613; PMCID: PMC3951457.
    24. Eckle T, Kewley EM, Brodsky KS, Tak E, Bonney S, Gobel M, Anderson D, Glover LE, Riegel AK, Colgan SP, Eltzschig HK. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol. 2014 Feb 01; 192(3):1249-56. PMID: 24391213; PMCID: PMC3946986.
    25. Kominsky DJ, Campbell EL, Ehrentraut SF, Wilson KE, Kelly CJ, Glover LE, Collins CB, Bayless AJ, Saeedi B, Dobrinskikh E, Bowers BE, MacManus CF, Müller W, Colgan SP, Bruder D. IFN-?-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia. J Immunol. 2014 Feb 01; 192(3):1267-76. PMID: 24367025; PMCID: PMC4042245.
    26. Glover LE, Bowers BE, Saeedi B, Ehrentraut SF, Campbell EL, Bayless AJ, Dobrinskikh E, Kendrick AA, Kelly CJ, Burgess A, Miller L, Kominsky DJ, Jedlicka P, Colgan SP. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19820-5. PMID: 24248342; PMCID: PMC3856803.
    27. Colgan SP, Curtis VF, Campbell EL. The inflammatory tissue microenvironment in IBD. Inflamm Bowel Dis. 2013 Sep; 19(10):2238-44. PMID: 23702808; PMCID: PMC3749286.
    28. Keely S, Campbell EL, Baird AW, Hansbro PM, Shalwitz RA, Kotsakis A, McNamee EN, Eltzschig HK, Kominsky DJ, Colgan SP. Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. Mucosal Immunol. 2014 Jan; 7(1):114-23. PMID: 23695513; PMCID: PMC3772994.
    29. Zhang W, Zhang Y, Wang W, Dai Y, Ning C, Luo R, Sun K, Glover L, Grenz A, Sun H, Tao L, Zhang W, Colgan SP, Blackburn MR, Eltzschig HK, Kellems RE, Xia Y. Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension. Circ Res. 2013 May 24; 112(11):1466-78. PMID: 23584256; PMCID: PMC3886128.
    30. Kelly CJ, Glover LE, Campbell EL, Kominsky DJ, Ehrentraut SF, Bowers BE, Bayless AJ, Saeedi BJ, Colgan SP. Fundamental role for HIF-1a in constitutive expression of human ß defensin-1. Mucosal Immunol. 2013 Nov; 6(6):1110-8. PMID: 23462909; PMCID: PMC3740147.
    31. Colgan SP. Swimming through the gut: implications of fluid transport on the microbiome. Dig Dis Sci. 2013 Mar; 58(3):602-3. PMID: 23361577; PMCID: PMC4075287.
    32. Colgan SP, Ehrentraut SF, Glover LE, Kominsky DJ, Campbell EL. Contributions of neutrophils to resolution of mucosal inflammation. Immunol Res. 2013 Mar; 55(1-3):75-82. PMID: 22968707; PMCID: PMC4047712.
    33. Ehrentraut H, Clambey ET, McNamee EN, Brodsky KS, Ehrentraut SF, Poth JM, Riegel AK, Westrich JA, Colgan SP, Eltzschig HK. CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury. FASEB J. 2013 Jun; 27(6):2207-19. PMID: 23413361; PMCID: PMC3659359.
    34. Ehrentraut SF, Kominsky DJ, Glover LE, Campbell EL, Kelly CJ, Bowers BE, Bayless AJ, Colgan SP. Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response. J Immunol. 2013 Jan 01; 190(1):392-400. PMID: 23209320; PMCID: PMC3529810.
    35. Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK. Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol. 2013 Jul; 6(4):762-75. PMID: 23187315; PMCID: PMC3890100.
    36. Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2784-93. PMID: 22988108; PMCID: PMC3478644.
    37. Keely S, Kelly CJ, Weissmueller T, Burgess A, Wagner BD, Robertson CE, Harris JK, Colgan SP. Activated fluid transport regulates bacterial-epithelial interactions and significantly shifts the murine colonic microbiome. Gut Microbes. 2012 May-Jun; 3(3):250-60. PMID: 22614705; PMCID: PMC3427217.
    38. Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP, Eltzschig HK. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med. 2012 Apr 15; 18(5):774-82. PMID: 22504483; PMCID: PMC3378044.
    39. Kelly CJ, Colgan SP, Frank DN. Of microbes and meals: the health consequences of dietary endotoxemia. Nutr Clin Pract. 2012 Apr; 27(2):215-25. PMID: 22378797; PMCID: PMC4046172.
    40. Ehrentraut SF, Colgan SP. Implications of protein post-translational modifications in IBD. Inflamm Bowel Dis. 2012 Jul; 18(7):1378-88. PMID: 22223542; PMCID: PMC3378042.
    41. Colgan SP, Eltzschig HK. Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery. Annu Rev Physiol. 2012; 74:153-75. PMID: 21942704; PMCID: PMC3882030.
    42. Campbell EL, Serhan CN, Colgan SP. Antimicrobial aspects of inflammatory resolution in the mucosa: a role for proresolving mediators. J Immunol. 2011 Oct 01; 187(7):3475-81. PMID: 21934099; PMCID: PMC3362457.
    43. Zemans RL, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, De Langhe S, Reynolds SD, Mason RJ, Kahn M, Henson PM, Colgan SP, Downey GP. Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15990-5. PMID: 21880956; PMCID: PMC3179042.
    44. Glover LE, Colgan SP. Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis. Gastroenterology. 2011 May; 140(6):1748-55. PMID: 21530741; PMCID: PMC3093411.
    45. Kominsky DJ, Keely S, MacManus CF, Glover LE, Scully M, Collins CB, Bowers BE, Campbell EL, Colgan SP. An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. J Immunol. 2011 Jun 01; 186(11):6505-14. PMID: 21515785; PMCID: PMC3383860.
    46. MacManus CF, Campbell EL, Keely S, Burgess A, Kominsky DJ, Colgan SP. Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization. FASEB J. 2011 Jun; 25(6):1856-64. PMID: 21350119; PMCID: PMC3101032.
    47. Glover LE, Irizarry K, Scully M, Campbell EL, Bowers BE, Aherne CM, Kominsky DJ, MacManus CF, Colgan SP. IFN-? attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1ß. J Immunol. 2011 Feb 01; 186(3):1790-8. PMID: 21199896; PMCID: PMC4040106.
    48. Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL. NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis. 2011 Jun; 17(6):1359-72. PMID: 20872834; PMCID: PMC3026862.
    49. Wick MJ, Buesing EJ, Wehling CA, Loomis ZL, Cool CD, Zamora MR, Miller YE, Colgan SP, Hersh LB, Voelkel NF, Dempsey EC. Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011 Feb 01; 183(3):330-40. PMID: 20813891; PMCID: PMC3056229.
    50. Campbell EL, MacManus CF, Kominsky DJ, Keely S, Glover LE, Bowers BE, Scully M, Bruyninckx WJ, Colgan SP. Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14298-303. PMID: 20660763; PMCID: PMC2922533.
    51. Kominsky DJ, Campbell EL, Colgan SP. Metabolic shifts in immunity and inflammation. J Immunol. 2010 Apr 15; 184(8):4062-8. PMID: 20368286; PMCID: PMC4077461.
    52. Colgan SP, Taylor CT. Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol. 2010 May; 7(5):281-7. PMID: 20368740; PMCID: PMC4077542.
    53. Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL. Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterology. 2010 Jul; 139(1):259-69.e3. PMID: 20347817; PMCID: PMC3063899.
    54. Schingnitz U, Hartmann K, Macmanus CF, Eckle T, Zug S, Colgan SP, Eltzschig HK. Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol. 2010 May 01; 184(9):5271-9. PMID: 20348420; PMCID: PMC2858788.
    55. Eltzschig HK, Rivera-Nieves J, Colgan SP. Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation. Expert Opin Ther Targets. 2009 Nov; 13(11):1267-77. PMID: 19769545; PMCID: PMC4077533.
    56. Henes J, Schmit MA, Morote-Garcia JC, Mirakaj V, Köhler D, Glover L, Eldh T, Walter U, Karhausen J, Colgan SP, Rosenberger P. Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury. FASEB J. 2009 Dec; 23(12):4244-55. PMID: 19690214; PMCID: PMC2812050.
    57. Ahmad A, Ahmad S, Glover L, Miller SM, Shannon JM, Guo X, Franklin WA, Bridges JP, Schaack JB, Colgan SP, White CW. Adenosine A2A receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10684-9. PMID: 19541651; PMCID: PMC2705563.
    58. Frick JS, MacManus CF, Scully M, Glover LE, Eltzschig HK, Colgan SP. Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol. 2009 Apr 15; 182(8):4957-64. PMID: 19342675; PMCID: PMC2831100.
    59. Liu Q, Li J, Khoury J, Colgan SP, Ibla JC. Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation. J Biol Chem. 2009 May 15; 284(20):13686-95. PMID: 19297320; PMCID: PMC2679470.
    60. Fillon S, Robinson ZD, Colgan SP, Furuta GT. Epithelial function in eosinophilic gastrointestinal diseases. Immunol Allergy Clin North Am. 2009 Feb; 29(1):171-8, xii-xiii. PMID: 19141352.
      View in: PubMed
    61. Keely S, Glover LE, MacManus CF, Campbell EL, Scully MM, Furuta GT, Colgan SP. Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing. FASEB J. 2009 May; 23(5):1338-46. PMID: 19103643; PMCID: PMC2669428.
    62. Keely S, Ryan SM, Haddleton DM, Limer A, Mantovani G, Murphy EP, Colgan SP, Brayden DJ. Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers. J Control Release. 2009 Apr 02; 135(1):35-43. PMID: 19110018; PMCID: PMC4047761.
    63. Zemans RL, Colgan SP, Downey GP. Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol. 2009 May; 40(5):519-35. PMID: 18978300; PMCID: PMC2677434.
    64. Weissmüller T, Campbell EL, Rosenberger P, Scully M, Beck PL, Furuta GT, Colgan SP. PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell-expressed ecto-NTPDases. J Clin Invest. 2008 Nov; 118(11):3682-92. PMID: 18924612.
      View in: PubMed
    65. Eltzschig HK, Köhler D, Eckle T, Kong T, Robson SC, Colgan SP. Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood. 2009 Jan 01; 113(1):224-32. PMID: 18812468; PMCID: PMC2614635.
    66. Zheng W, Kuhlicke J, Jäckel K, Eltzschig HK, Singh A, Sjöblom M, Riederer B, Weinhold C, Seidler U, Colgan SP, Karhausen J. Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. FASEB J. 2009 Jan; 23(1):204-13. PMID: 18779379; PMCID: PMC2626614.
    67. Eltzschig HK, Macmanus CF, Colgan SP. Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface. Trends Cardiovasc Med. 2008 Apr; 18(3):103-7. PMID: 18436149; PMCID: PMC2711033.
    68. Louis NA, Robinson AM, MacManus CF, Karhausen J, Scully M, Colgan SP. Control of IFN-alphaA by CD73: implications for mucosal inflammation. J Immunol. 2008 Mar 15; 180(6):4246-55. PMID: 18322237.
      View in: PubMed
    69. Hartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Yazdi AS, Matteoli G, Bohn E, Autenrieth IB, Karhausen J, Neumann D, Colgan SP, Kempf VA. Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. Gastroenterology. 2008 Mar; 134(3):756-67. PMID: 18325389.
      View in: PubMed
    70. Taylor CT, Colgan SP. Hypoxia and gastrointestinal disease. J Mol Med (Berl). 2007 Dec; 85(12):1295-300. PMID: 18026919.
      View in: PubMed
    71. Kong T, Scully M, Shelley CS, Colgan SP. Identification of Pur alpha as a new hypoxia response factor responsible for coordinated induction of the beta 2 integrin family. J Immunol. 2007 Aug 01; 179(3):1934-41. PMID: 17641060.
      View in: PubMed
    72. Campbell EL, Louis NA, Tomassetti SE, Canny GO, Arita M, Serhan CN, Colgan SP. Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J. 2007 Oct; 21(12):3162-70. PMID: 17496159.
      View in: PubMed
    73. Rosenberger P, Khoury J, Kong T, Weissmüller T, Robinson AM, Colgan SP. Identification of vasodilator-stimulated phosphoprotein (VASP) as an HIF-regulated tissue permeability factor during hypoxia. FASEB J. 2007 Aug; 21(10):2613-21. PMID: 17412998; PMCID: PMC4049288.
    74. Khoury J, Ibla JC, Neish AS, Colgan SP. Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. J Clin Invest. 2007 Mar; 117(3):703-11. PMID: 17318263; PMCID: PMC1797604.
    75. Sun YP, Oh SF, Uddin J, Yang R, Gotlinger K, Campbell E, Colgan SP, Petasis NA, Serhan CN. Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30; 282(13):9323-34. PMID: 17244615.
      View in: PubMed
    76. Louis NA, Campbell E, Colgan SP. Model systems to investigate neutrophil adhesion and chemotaxis. Methods Mol Biol. 2007; 412:257-70. PMID: 18453117.
      View in: PubMed
    77. Louis NA, Hamilton KE, Canny G, Shekels LL, Ho SB, Colgan SP. Selective induction of mucin-3 by hypoxia in intestinal epithelia. J Cell Biochem. 2006 Dec 15; 99(6):1616-27. PMID: 16823775.
      View in: PubMed
    78. Kong T, Westerman KA, Faigle M, Eltzschig HK, Colgan SP. HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J. 2006 Nov; 20(13):2242-50. PMID: 17077301.
      View in: PubMed
    79. Eltzschig HK, Eckle T, Mager A, Küper N, Karcher C, Weissmüller T, Boengler K, Schulz R, Robson SC, Colgan SP. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res. 2006 Nov 10; 99(10):1100-8. PMID: 17038639.
      View in: PubMed
    80. Patel NJ, Zaborina O, Wu L, Wang Y, Wolfgeher DJ, Valuckaite V, Ciancio MJ, Kohler JE, Shevchenko O, Colgan SP, Chang EB, Turner JR, Alverdy JC. Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G134-42. PMID: 16901993; PMCID: PMC2694754.
    81. Canny GO, Trifonova RT, Kindelberger DW, Colgan SP, Fichorova RN. Expression and function of bactericidal/permeability-increasing protein in human genital tract epithelial cells. J Infect Dis. 2006 Aug 15; 194(4):498-502. PMID: 16845634.
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    82. Costa C, Zhao L, Shen Y, Su X, Hao L, Colgan SP, Stahl GL, Zhou T, Wang Y. Role of complement component C5 in cerebral ischemia/reperfusion injury. Brain Res. 2006 Jul 19; 1100(1):142-51. PMID: 16780818.
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    83. Colgan SP, Eltzschig HK, Eckle T, Thompson LF. Physiological roles for ecto-5'-nucleotidase (CD73). Purinergic Signal. 2006 Jun; 2(2):351-60. PMID: 18404475; PMCID: PMC2254482.
    84. Eltzschig HK, Faigle M, Knapp S, Karhausen J, Ibla J, Rosenberger P, Odegard KC, Laussen PC, Thompson LF, Colgan SP. Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood. 2006 Sep 01; 108(5):1602-10. PMID: 16670267; PMCID: PMC1895500.
    85. Ibla JC, Khoury J, Kong T, Robinson A, Colgan SP. Transcriptional repression of Na-K-2Cl cotransporter NKCC1 by hypoxia-inducible factor-1. Am J Physiol Cell Physiol. 2006 Aug; 291(2):C282-9. PMID: 16571862.
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    86. Serhan CN, Gotlinger K, Hong S, Lu Y, Siegelman J, Baer T, Yang R, Colgan SP, Petasis NA. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. J Immunol. 2006 Feb 01; 176(3):1848-59. PMID: 16424216.
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    87. Louis NA, Daniels D, Colgan SP. Cell-cell interactions on solid matrices. Methods Mol Biol. 2006; 341:51-9. PMID: 16799188.
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    88. Eltzschig HK, Abdulla P, Hoffman E, Hamilton KE, Daniels D, Schönfeld C, Löffler M, Reyes G, Duszenko M, Karhausen J, Robinson A, Westerman KA, Coe IR, Colgan SP. HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J Exp Med. 2005 Dec 05; 202(11):1493-505. PMID: 16330813; PMCID: PMC2213326.
    89. Canny G, Cario E, Lennartsson A, Gullberg U, Brennan C, Levy O, Colgan SP. Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein. Am J Physiol Gastrointest Liver Physiol. 2006 Mar; 290(3):G557-67. PMID: 16282362.
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    90. Louis NA, Hamilton KE, Colgan SP. Lipid mediator networks and leukocyte transmigration. Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct; 73(3-4):197-202. PMID: 15979294.
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    91. Karhausen J, Kong T, Narravula S, Colgan SP. Induction of the von Hippel-Lindau tumor suppressor gene by late hypoxia limits HIF-1 expression. J Cell Biochem. 2005 Aug 15; 95(6):1264-75. PMID: 15962286.
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    92. Weissmuller T, Eltzschig HK, Colgan SP. Dynamic purine signaling and metabolism during neutrophil-endothelial interactions. Purinergic Signal. 2005 Sep; 1(3):229-39. PMID: 18404508; PMCID: PMC2096542.
    93. Louis NA, Hamilton KE, Kong T, Colgan SP. HIF-dependent induction of apical CD55 coordinates epithelial clearance of neutrophils. FASEB J. 2005 Jun; 19(8):950-9. PMID: 15923405.
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    94. Canny G, Colgan SP. Events at the host-microbial interface of the gastrointestinal tract. I. Adaptation to a microbial world: role of epithelial bactericidal/permeability-increasing protein. Am J Physiol Gastrointest Liver Physiol. 2005 Apr; 288(4):G593-7. PMID: 15764808.
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    95. Blumberg RS, Pitman RS, Taylor CT, Colgan SP. Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alpha. J Interferon Cytokine Res. 2005 Apr; 25(4):209-19. PMID: 15812247.
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    96. Karhausen J, Haase VH, Colgan SP. Inflammatory hypoxia: role of hypoxia-inducible factor. Cell Cycle. 2005 Feb; 4(2):256-8. PMID: 15655360.
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    97. Thompson LF, Eltzschig HK, Ibla JC, Van De Wiele CJ, Resta R, Morote-Garcia JC, Colgan SP. Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med. 2004 Dec 06; 200(11):1395-405. PMID: 15583013; PMCID: PMC1237012.
    98. Kaser A, Nieuwenhuis EE, Strober W, Mayer L, Fuss I, Colgan S, Blumberg RS. Natural killer T cells in mucosal homeostasis. Ann N Y Acad Sci. 2004 Dec; 1029:154-68. PMID: 15681754.
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    99. Karhausen J, Furuta GT, Tomaszewski JE, Johnson RS, Colgan SP, Haase VH. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest. 2004 Oct; 114(8):1098-106. PMID: 15489957; PMCID: PMC522241.
    100. Eltzschig HK, Thompson LF, Karhausen J, Cotta RJ, Ibla JC, Robson SC, Colgan SP. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood. 2004 Dec 15; 104(13):3986-92. PMID: 15319286.
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    101. Kong T, Eltzschig HK, Karhausen J, Colgan SP, Shelley CS. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10440-5. PMID: 15235127; PMCID: PMC478589.
    102. Kaser A, Nieuwenhuis EE, Strober W, Fuss I, Colgan S, Blumberg RS. CD1d-restricted T cell pathways at the epithelial-lymphocyte-luminal interface. J Pediatr Gastroenterol Nutr. 2004 Jun; 39 Suppl 3:S719-22. PMID: 15167359.
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    103. Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, Chen D, Kaser A, Glickman J, Kuo T, Little A, Morrison J, Corazza N, Kim JY, Colgan SP, Young SG, Exley M, Blumberg RS. CD1d function is regulated by microsomal triglyceride transfer protein. Nat Med. 2004 May; 10(5):535-9. PMID: 15107843.
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    104. Gronert K, Kantarci A, Levy BD, Clish CB, Odparlik S, Hasturk H, Badwey JA, Colgan SP, Van Dyke TE, Serhan CN. A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage. J Immunol. 2004 Feb 01; 172(3):1856-61. PMID: 14734770; PMCID: PMC4318492.
    105. Comerford KM, Colgan SP. Assessing oxygen sensitivity of the multidrug resistance (MDR) gene. Methods Enzymol. 2004; 381:376-87. PMID: 15063687.
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    106. Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, Colgan SP, Stahl GL, Merched A, Petasis NA, Chan L, Van Dyke TE. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol. 2003 Dec 15; 171(12):6856-65. PMID: 14662892.
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    107. Lawrence DW, Bruyninckx WJ, Louis NA, Lublin DM, Stahl GL, Parkos CA, Colgan SP. Antiadhesive role of apical decay-accelerating factor (CD55) in human neutrophil transmigration across mucosal epithelia. J Exp Med. 2003 Oct 06; 198(7):999-1010. PMID: 14530374; PMCID: PMC2194216.
    108. Colgan SP, Pitman RS, Nagaishi T, Mizoguchi A, Mizoguchi E, Mayer LF, Shao L, Sartor RB, Subjeck JR, Blumberg RS. Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells. J Clin Invest. 2003 Sep; 112(5):745-54. PMID: 12952923; PMCID: PMC182184.
    109. Eltzschig HK, Ibla JC, Furuta GT, Leonard MO, Jacobson KA, Enjyoji K, Robson SC, Colgan SP. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med. 2003 Sep 01; 198(5):783-96. PMID: 12939345; PMCID: PMC2194189.
    110. Levy O, Canny G, Serhan CN, Colgan SP. Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia. Biochem Soc Trans. 2003 Aug; 31(Pt 4):795-800. PMID: 12887308.
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    111. van de Wal Y, Corazza N, Allez M, Mayer LF, Iijima H, Ryan M, Cornwall S, Kaiserlian D, Hershberg R, Koezuka Y, Colgan SP, Blumberg RS. Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells. Gastroenterology. 2003 May; 124(5):1420-31. PMID: 12730881.
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    112. Fierro IM, Colgan SP, Bernasconi G, Petasis NA, Clish CB, Arita M, Serhan CN. Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells. J Immunol. 2003 Mar 01; 170(5):2688-94. PMID: 12594298.
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    113. Karhausen J, Ibla JC, Colgan SP. Implications of hypoxia on mucosal barrier function. Cell Mol Biol (Noisy-le-grand). 2003 Feb; 49(1):77-87. PMID: 12839339.
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    114. Comerford KM, Leonard MO, Karhausen J, Carey R, Colgan SP, Taylor CT. Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):986-91. PMID: 12552083; PMCID: PMC298713.
    115. Schottelius AJ, Giesen C, Asadullah K, Fierro IM, Colgan SP, Bauman J, Guilford W, Perez HD, Parkinson JF. An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile. J Immunol. 2002 Dec 15; 169(12):7063-70. PMID: 12471142.
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    116. Serhan CN, Hong S, Gronert K, Colgan SP, Devchand PR, Mirick G, Moussignac RL. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med. 2002 Oct 21; 196(8):1025-37. PMID: 12391014; PMCID: PMC2194036.
    117. Synnestvedt K, Furuta GT, Comerford KM, Louis N, Karhausen J, Eltzschig HK, Hansen KR, Thompson LF, Colgan SP. Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest. 2002 Oct; 110(7):993-1002. PMID: 12370277; PMCID: PMC151145.
    118. Comerford KM, Wallace TJ, Karhausen J, Louis NA, Montalto MC, Colgan SP. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res. 2002 Jun 15; 62(12):3387-94. PMID: 12067980.
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    119. Lawrence DW, Comerford KM, Colgan SP. Role of VASP in reestablishment of epithelial tight junction assembly after Ca2+ switch. Am J Physiol Cell Physiol. 2002 Jun; 282(6):C1235-45. PMID: 11997237.
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    120. Nieuwenhuis EE, Matsumoto T, Exley M, Schleipman RA, Glickman J, Bailey DT, Corazza N, Colgan SP, Onderdonk AB, Blumberg RS. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med. 2002 Jun; 8(6):588-93. PMID: 12042809.
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    121. Colgan SP. Lipid mediators in epithelial cell-cell interactions. Cell Mol Life Sci. 2002 May; 59(5):754-60. PMID: 12088276.
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    122. Comerford KM, Lawrence DW, Synnestvedt K, Levi BP, Colgan SP. Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability. FASEB J. 2002 Apr; 16(6):583-5. PMID: 11919161.
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    123. Canny G, Levy O, Furuta GT, Narravula-Alipati S, Sisson RB, Serhan CN, Colgan SP. Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3902-7. PMID: 11891303; PMCID: PMC122621.
    124. Collard CD, Park KA, Montalto MC, Alapati S, Buras JA, Stahl GL, Colgan SP. Neutrophil-derived glutamate regulates vascular endothelial barrier function. J Biol Chem. 2002 Apr 26; 277(17):14801-11. PMID: 11847215.
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    125. Colgan SP, Comerford KM, Lawrence DW. Epithelial cell-neutrophil interactions in the alimentary tract: a complex dialog in mucosal surveillance and inflammation. ScientificWorldJournal. 2002 Jan 09; 2:76-88. PMID: 12806040.
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    126. Brand S, Sakaguchi T, Gu X, Colgan SP, Reinecker HC. Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells. Gastroenterology. 2002 Jan; 122(1):166-77. PMID: 11781291.
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    127. Colgan SP, Taylor CT, Narravula S, Synnestvedt K, Blume ED. Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1 alpha, a potent epithelial secretagogue. Adv Exp Med Biol. 2002; 507:107-12. PMID: 12664572.
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    128. Lee SY, Madan A, Furuta GT, Colgan SP, Sibley E. Lactase gene transcription is activated in response to hypoxia in intestinal epithelial cells. Mol Genet Metab. 2002 Jan; 75(1):65-9. PMID: 11825065.
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    129. Lencer WI, Barrett K, Colgan S, Cohen MB, Duggan CP, Kotelchuck M, Rhoads JM. Research agenda for pediatric gastroenterology, hepatology and nutrition: secretion and diarrhea. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 3:S246-9. PMID: 12394359.
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    130. Narravula S, Colgan SP. Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia. J Immunol. 2001 Jun 15; 166(12):7543-8. PMID: 11390509.
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    131. Blumberg RS, van de Wal Y, Claypool S, Corazza N, Dickinson B, Nieuwenhuis E, Pitman R, Spiekermann G, Zhu X, Colgan S, Lencer WI. The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function. Acta Odontol Scand. 2001 Jun; 59(3):139-44. PMID: 11501882; PMCID: PMC2824335.
    132. Bruyninckx WJ, Comerford KM, Lawrence DW, Colgan SP. Phosphoinositide 3-kinase modulation of beta(3)-integrin represents an endogenous "braking" mechanism during neutrophil transmatrix migration. Blood. 2001 May 15; 97(10):3251-8. PMID: 11342456.
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    133. Furuta GT, Turner JR, Taylor CT, Hershberg RM, Comerford K, Narravula S, Podolsky DK, Colgan SP. Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J Exp Med. 2001 May 07; 193(9):1027-34. PMID: 11342587; PMCID: PMC2193432.
    134. Reaves TA, Colgan SP, Selvaraj P, Pochet MM, Walsh S, Nusrat A, Liang TW, Madara JL, Parkos CA. Neutrophil transepithelial migration: regulation at the apical epithelial surface by Fc-mediated events. Am J Physiol Gastrointest Liver Physiol. 2001 Apr; 280(4):G746-54. PMID: 11254502.
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    135. Serhan CN, Clish CB, Brannon J, Colgan SP, Gronert K, Chiang N. Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions. J Physiol Pharmacol. 2000 Dec; 51(4 Pt 1):643-54. PMID: 11192938.
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    136. Narravula S, Lennon PF, Mueller BU, Colgan SP. Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier function. J Immunol. 2000 Nov 01; 165(9):5262-8. PMID: 11046060.
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    137. Taylor CT, Furuta GT, Synnestvedt K, Colgan SP. Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12091-6. PMID: 11035795; PMCID: PMC17299.
    138. Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert K. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J Exp Med. 2000 Oct 16; 192(8):1197-204. PMID: 11034610; PMCID: PMC2195872.
    139. Kim HS, Colgan SP, Pitman R, Hershberg RM, Blumberg RS. Human CD1d associates with prolyl-4-hydroxylase during its biosynthesis. Mol Immunol. 2000 Oct; 37(14):861-8. PMID: 11257307.
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    140. Furuta GT, Dzus AL, Taylor CT, Colgan SP. Parallel induction of epithelial surface-associated chemokine and proteoglycan by cellular hypoxia: implications for neutrophil activation. J Leukoc Biol. 2000 Aug; 68(2):251-9. PMID: 10947070.
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    141. Colgan SP, Hershberg RM, Furuta GT, Blumberg RS. Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13938-43. PMID: 10570177; PMCID: PMC24169.
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    143. Taylor CT, Fueki N, Agah A, Hershberg RM, Colgan SP. Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-alpha. J Biol Chem. 1999 Jul 02; 274(27):19447-54. PMID: 10383461.
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    144. Blumberg RS, Lencer WI, Zhu X, Kim HS, Claypool S, Balk SP, Saubermann LJ, Colgan SP. Antigen presentation by intestinal epithelial cells. Immunol Lett. 1999 Jun 15; 69(1):7-11. PMID: 10436875.
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    145. Somnay-Wadgaonkar K, Nusrat A, Kim HS, Canchis WP, Balk SP, Colgan SP, Blumberg RS. Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form. Int Immunol. 1999 Mar; 11(3):383-92. PMID: 10221650.
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    146. Collard CD, Bukusoglu C, Agah A, Colgan SP, Reenstra WR, Morgan BP, Stahl GL. Hypoxia-induced expression of complement receptor type 1 (CR1, CD35) in human vascular endothelial cells. Am J Physiol. 1999 Feb; 276(2 Pt 1):C450-8. PMID: 9950773.
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    147. Lennon PF, Taylor CT, Stahl GL, Colgan SP. Neutrophil-derived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation. J Exp Med. 1998 Oct 19; 188(8):1433-43. PMID: 9782120; PMCID: PMC2213403.
    148. Blume ED, Taylor CT, Lennon PF, Stahl GL, Colgan SP. Activated endothelial cells elicit paracrine induction of epithelial chloride secretion. 6-Keto-PGF1alpha is an epithelial secretagogue. J Clin Invest. 1998 Sep 15; 102(6):1161-72. PMID: 9739050; PMCID: PMC509099.
    149. Friedman GB, Taylor CT, Parkos CA, Colgan SP. Epithelial permeability induced by neutrophil transmigration is potentiated by hypoxia: role of intracellular cAMP. J Cell Physiol. 1998 Jul; 176(1):76-84. PMID: 9618147.
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    150. Taylor CT, Dzus AL, Colgan SP. Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha. Gastroenterology. 1998 Apr; 114(4):657-68. PMID: 9516386.
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    151. Maddox JF, Colgan SP, Clish CB, Petasis NA, Fokin VV, Serhan CN. Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity. FASEB J. 1998 Apr; 12(6):487-94. PMID: 9535221.
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    152. Gronert K, Colgan SP, Serhan CN. Characterization of human neutrophil and endothelial cell ligand-operated extracellular acidification rate by microphysiometry: impact of reoxygenation. J Pharmacol Exp Ther. 1998 Apr; 285(1):252-61. PMID: 9536019.
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    153. Colgan SP. Nitric oxide and intestinal epithelia: just say NO. Gastroenterology. 1998 Mar; 114(3):601-3. PMID: 9496953.
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    154. Taylor CT, Lisco SJ, Awtrey CS, Colgan SP. Hypoxia inhibits cyclic nucleotide-stimulated epithelial ion transport: role for nucleotide cyclases as oxygen sensors. J Pharmacol Exp Ther. 1998 Feb; 284(2):568-75. PMID: 9454799.
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    155. McCormick BA, Parkos CA, Colgan SP, Carnes DK, Madara JL. Apical secretion of a pathogen-elicited epithelial chemoattractant activity in response to surface colonization of intestinal epithelia by Salmonella typhimurium. J Immunol. 1998 Jan 01; 160(1):455-66. PMID: 9552004.
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    156. Zünd G, Uezono S, Stahl GL, Dzus AL, McGowan FX, Hickey PR, Colgan SP. Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes. Am J Physiol. 1997 Nov; 273(5 Pt 1):C1571-80. PMID: 9374642.
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    157. Christ AD, Colgan SP, Balk SP, Blumberg RS. Human intestinal epithelial cell lines produce factor(s) that inhibit CD3-mediated T-lymphocyte proliferation. Immunol Lett. 1997 Aug; 58(3):159-65. PMID: 9293397.
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    164. Hofman P, D'Andrea L, Carnes D, Colgan SP, Madara JL. Intestinal epithelial cytoskeleton selectively constrains lumen-to-tissue migration of neutrophils. Am J Physiol. 1996 Jul; 271(1 Pt 1):C312-20. PMID: 8760060.
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    165. Zünd G, Madara JL, Dzus AL, Awtrey CS, Colgan SP. Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion. J Biol Chem. 1996 Mar 29; 271(13):7460-4. PMID: 8631774.
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    166. Parkos CA, Colgan SP, Liang TW, Nusrat A, Bacarra AE, Carnes DK, Madara JL. CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia. J Cell Biol. 1996 Feb; 132(3):437-50. PMID: 8636220; PMCID: PMC2120714.
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    168. Nusrat A, Giry M, Turner JR, Colgan SP, Parkos CA, Carnes D, Lemichez E, Boquet P, Madara JL. Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia. Proc Natl Acad Sci U S A. 1995 Nov 07; 92(23):10629-33. PMID: 7479854; PMCID: PMC40665.
    169. Serhan CN, Maddox JF, Petasis NA, Akritopoulou-Zanze I, Papayianni A, Brady HR, Colgan SP, Madara JL. Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry. 1995 Nov 07; 34(44):14609-15. PMID: 7578068.
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    170. Colgan SP, Parkos CA, McGuirk D, Brady HR, Papayianni AA, Frendl G, Madara JL. Receptors involved in carbohydrate binding modulate intestinal epithelial-neutrophil interactions. J Biol Chem. 1995 May 05; 270(18):10531-9. PMID: 7537733.
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    171. Parkos CA, Colgan SP, Bacarra AE, Nusrat A, Delp-Archer C, Carlson S, Su DH, Madara JL. Intestinal epithelia (T84) possess basolateral ligands for CD11b/CD18-mediated neutrophil adherence. Am J Physiol. 1995 Feb; 268(2 Pt 1):C472-9. PMID: 7532360.
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    172. Resnick MB, Colgan SP, Parkos CA, Delp-Archer C, McGuirk D, Weller PF, Madara JL. Human eosinophils migrate across an intestinal epithelium in response to platelet-activating factor. Gastroenterology. 1995 Feb; 108(2):409-16. PMID: 7835581.
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    173. Sanders SE, Madara JL, McGuirk DK, Gelman DS, Colgan SP. Assessment of inflammatory events in epithelial permeability: a rapid screening method using fluorescein dextrans. Epithelial Cell Biol. 1995; 4(1):25-34. PMID: 8563793.
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    174. Colgan SP, Resnick MB, Parkos CA, Delp-Archer C, McGuirk D, Bacarra AE, Weller PF, Madara JL. IL-4 directly modulates function of a model human intestinal epithelium. J Immunol. 1994 Sep 01; 153(5):2122-9. PMID: 7914217.
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    176. Kaoutzani P, Colgan SP, Cepek KL, Burkard PG, Carlson S, Delp-Archer C, Brenner MB, Madara JL. Reconstitution of cultured intestinal epithelial monolayers with a mucosal-derived T lymphocyte cell line. Modulation of epithelial phenotype dependent on lymphocyte-basolateral membrane apposition. J Clin Invest. 1994 Aug; 94(2):788-96. PMID: 8040334; PMCID: PMC296159.
    177. Colgan SP, Parkos CA, Matthews JB, D'Andrea L, Awtrey CS, Lichtman AH, Delp-Archer C, Madara JL. Interferon-gamma induces a cell surface phenotype switch on T84 intestinal epithelial cells. Am J Physiol. 1994 Aug; 267(2 Pt 1):C402-10. PMID: 8074176.
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    178. Balk SP, Burke S, Polischuk JE, Frantz ME, Yang L, Porcelli S, Colgan SP, Blumberg RS. Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. Science. 1994 Jul 08; 265(5169):259-62. PMID: 7517575.
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    179. Resnick MB, Colgan SP, Patapoff TW, Mrsny RJ, Awtrey CS, Delp-Archer C, Weller PF, Madara JL. Activated eosinophils evoke chloride secretion in model intestinal epithelia primarily via regulated release of 5'-AMP. J Immunol. 1993 Nov 15; 151(10):5716-23. PMID: 8228257.
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    180. McCormick BA, Colgan SP, Delp-Archer C, Miller SI, Madara JL. Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils. J Cell Biol. 1993 Nov; 123(4):895-907. PMID: 8227148; PMCID: PMC2200157.
    181. Colgan SP, Serhan CN, Parkos CA, Delp-Archer C, Madara JL. Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers. J Clin Invest. 1993 Jul; 92(1):75-82. PMID: 8326019; PMCID: PMC293534.
    182. Madara JL, Patapoff TW, Gillece-Castro B, Colgan SP, Parkos CA, Delp C, Mrsny RJ. 5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers. J Clin Invest. 1993 May; 91(5):2320-5. PMID: 8486793; PMCID: PMC288238.
    183. Colgan SP, Parkos CA, Delp C, Arnaout MA, Madara JL. Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion. J Cell Biol. 1993 Feb; 120(3):785-98. PMID: 8093887; PMCID: PMC2119532.
    184. Colgan SP, Gasper PW, Thrall MA, Boone TC, Blancquaert AM, Bruyninckx WJ. Neutrophil function in normal and Chediak-Higashi syndrome cats following administration of recombinant canine granulocyte colony-stimulating factor. Exp Hematol. 1992 Nov; 20(10):1229-34. PMID: 1385198.
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    185. Grauer GF, Rose BJ, Toolan L, Thrall MA, Colgan SP. Effects of low-dose aspirin and specific thromboxane synthetase inhibition on whole blood platelet aggregation and adenosine triphosphate secretion in healthy dogs. Am J Vet Res. 1992 Sep; 53(9):1631-5. PMID: 1416368.
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    186. Colgan SP, Matthews JB, Parkos CA, Delp C, Awtrey CS, Madara JL. The myeloid leukemia cell line HL-60 produces a factor that induces chloride secretion in cultured epithelial cells. J Leukoc Biol. 1992 Aug; 52(2):183-7. PMID: 1506774.
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    187. Madara JL, Parkos C, Colgan S, MacLeod RJ, Nash S, Matthews J, Delp C, Lencer W. Cl- secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue. J Clin Invest. 1992 Jun; 89(6):1938-44. PMID: 1602001; PMCID: PMC295894.
    188. Parkos CA, Colgan SP, Delp C, Arnaout MA, Madara JL. Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways. J Cell Biol. 1992 May; 117(4):757-64. PMID: 1577855; PMCID: PMC2289458.
    189. Colgan SP, Blancquaert AM, Thrall MA, Bruyninckx WJ. Defective in vitro motility of polymorphonuclear leukocytes of homozygote and heterozygote Chediak-Higashi cats. Vet Immunol Immunopathol. 1992 Mar; 31(3-4):205-27. PMID: 1589952.
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    190. Madara JL, Parkos C, Colgan S, Nusrat A, Atisook K, Kaoutzani P. The movement of solutes and cells across tight junctions. Ann N Y Acad Sci. 1992; 664:47-60. PMID: 1456668.
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    191. Colgan SP, Hull-Thrall MA, Gasper PW, Gould DH, Rose BJ, Fulton R, Blanquaert AM, Bruyninckx WJ. Restoration of neutrophil and platelet function in feline Chediak-Higashi syndrome by bone marrow transplantation. Bone Marrow Transplant. 1991 May; 7(5):365-74. PMID: 2070146.
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    192. Reagan WJ, Garry F, Thrall MA, Colgan S, Hutchison J, Weiser MG. The clinicopathologic, light, and scanning electron microscopic features of eperythrozoonosis in four naturally infected llamas. Vet Pathol. 1990 Nov; 27(6):426-31. PMID: 2278130.
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    193. Blancquaert AB, Colgan SP, Bruyninckx WJ. Influence of technical parameters on the in vitro motility of equine neutrophils in the presence of streptococcal culture supernatant. Vet Immunol Immunopathol. 1989 Nov 30; 23(1-2):85-101. PMID: 2515650.
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    194. Colgan SP, Hull Thrall MA, Gasper PW. Platelet aggregation and ATP secretion in whole blood of normal cats and cats homozygous and heterozygous for Chediak-Higashi syndrome. Blood Cells. 1989; 15(3):585-95; discussion 596-600. PMID: 2620102.
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    195. Blancquaert AM, Colgan SP, Bruyninckx WJ. Chemotactic and chemokinetic activity of Streptococcus faecalis culture supernatant for equine neutrophils. Vet Immunol Immunopathol. 1988 Oct; 19(3-4):285-97. PMID: 3150886.
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