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Alexander S Dowdell

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
    Other Positions
    TitleAffiliate - VA
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-MED
    DivisionGastroenterology


    Collapse Research 
    Collapse research activities and funding
    IK2BX006088     (DOWDELL, ALEXANDER SHEA)Oct 1, 2023 - Sep 30, 2028
    NIH
    HIF-Regulated Autophagy in Host-microbe Interactions
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dowdell AS, Roer RL, Bhagavatula G, Cartwright IM, Cohen RH, Countess JA, Koch SD, Lee JS, Liu L, Steiner CA, Thompson NT, Villamaria ZF, Welch N, Worledge CS, Zhou L, Vazquez-Torres A, Colgan SP. Metabolic host-microbe crosstalk in stabilization of epithelial HIF. Microbiome. 2026 May 30. PMID: 42216217.
      View in: PubMed
    2. Ornelas A, Countess JA, Kim JY, Cohen RH, Gomez BD, Roer RL, Minhajuddin F, Yenugudhati Vijaya Sai K, Zhou L, Dunn JLM, Chandler C, Reigan P, Cartwright IM, Hall CHT, Bhagavatula G, Onyiah JC, Dowdell AS, Colgan SP. Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosa. Proc Natl Acad Sci U S A. 2026 Apr 14; 123(15):e2527863123. PMID: 41955110.
      View in: PubMed
    3. Ornelas A, Countess JA, Kim JY, Cohen RH, Gomez BD, Roer RL, Minhajuddin F, Yenugudhati Vijaya Sai K, Zhou L, Dunn JLM, Reigan P, Cartwright IM, Hall CHT, Bhagavatula G, Onyiah JC, Dowdell AS, Colgan SP. Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosa. bioRxiv. 2026 Jan 08. PMID: 41542554.
      View in: PubMed
    4. Dowdell AS, Colgan SP. Microbial trash to metabolic treasure. Immunometabolism (Cobham). 2025 Jul; 7(3):e00067. PMID: 40698198.
      View in: PubMed
    5. Dowdell AS, Roer R, Bhagavatula G, Cartwright IM, Cohen RH, Countess JA, Koch SD, Lee JS, Steiner CA, Thompson NT, Villamaria ZF, Welch NM, Worledge CS, Zhou L, Colgan SP. Regulation of Epithelial HIF by Probiotic Escherichia coli. bioRxiv. 2025 May 15. PMID: 40463037.
      View in: PubMed
    6. Seymour BJ, Trent B, Allen BE, Berlinberg AJ, Tangchittsumran J, Jubair WK, Chriswell ME, Liu S, Ornelas A, Stahly A, Alexeev EE, Dowdell AS, Sneed SL, Fechtner S, Kofonow JM, Robertson CE, Dillon SM, Wilson CC, Anthony RM, Frank DN, Colgan SP, Kuhn KA. Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice. J Clin Invest. 2023 12 19; 134(4). PMID: 38113112.
      View in: PubMed
    7. Alula KM, Dowdell AS, LeBere B, Lee JS, Levens CL, Kuhn KA, Kaipparettu BA, Thompson WE, Blumberg RS, Colgan SP, Theiss AL. Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in mice. Microbiome. 2023 11 17; 11(1):256. PMID: 37978573.
      View in: PubMed
    8. Seymour BJ, Trent B, Allen B, Berlinberg AJ, Tangchittsumran J, Jubair WK, Chriswell ME, Liu S, Ornelas A, Stahly A, Alexeev EE, Dowdell AS, Sneed SL, Fechtner S, Kofonow JM, Robertson CE, Dillon SM, Wilson CC, Anthony RM, Frank DN, Colgan SP, Kuhn KA. Microbiota-dependent indole production is required for the development of collagen-induced arthritis. bioRxiv. 2023 Oct 13. PMID: 37873395.
      View in: PubMed
    9. Ornelas A, Welch N, Countess JA, Zhou L, Wang RX, Dowdell AS, Colgan SP. Mimicry of microbially-derived butyrate reveals templates for potent intestinal epithelial HIF stabilizers. Gut Microbes. 2023 12; 15(2):2267706. PMID: 37822087.
      View in: PubMed
    10. Hall CHT, Lanis JM, Dowdell AS, Murphy EM, Bhagavatula G, Neuhart RM, Vijaya Sai KY, Colgan SP. Fundamental role for the creatine kinase pathway in protection from murine colitis. Mucosal Immunol. 2023 12; 16(6):817-825. PMID: 37716510.
      View in: PubMed
    11. Hall CH, Lanis JM, Dowdell AS, Murphy EM, Colgan SP. Fundamental role for the creatine kinase pathway in protection from murine colitis. bioRxiv. 2023 Jun 09. PMID: 37333192.
      View in: PubMed
    12. Dowdell AS, Cartwright IM, Kitzenberg DA, Kostelecky RE, Mahjoob O, Saeedi BJ, Welch N, Glover LE, Colgan SP. Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination. Cell Rep. 2022 09 27; 40(13):111409. PMID: 36170839.
      View in: PubMed
    13. Cartwright IM, Dowdell AS, Hanson C, Kostelecky RE, Welch N, Steiner CA, Colgan SP. Contact-dependent, polarized acidification response during neutrophil-epithelial interactions. J Leukoc Biol. 2022 12; 112(6):1543-1553. PMID: 35674095.
      View in: PubMed
    14. de Graaf DM, Wang RX, Amo-Aparicio J, Lee JS, Dowdell AS, Tengesdal IW, Marchetti C, Colgan SP, Joosten LAB, Dinarello CA. IL-38 Gene Deletion Worsens Murine Colitis. Front Immunol. 2022; 13:840719. PMID: 35693797.
      View in: PubMed
    15. Pereira MJ, Wager B, Garrigues RJ, Gerlach E, Quinn JD, Dowdell AS, Osburne MS, Zückert WR, Kraiczy P, Garcia BL, Leong JM. Lipoproteome screening of the Lyme disease agent identifies inhibitors of antibody-mediated complement killing. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2117770119. PMID: 35312359.
      View in: PubMed
    16. Ornelas A, Dowdell AS, Lee JS, Colgan SP. Microbial Metabolite Regulation of Epithelial Cell-Cell Interactions and Barrier Function. Cells. 2022 03 10; 11(6). PMID: 35326394.
      View in: PubMed
    17. Dowdell AS, Colgan SP. Metabolic Host-Microbiota Interactions in Autophagy and the Pathogenesis of Inflammatory Bowel Disease (IBD). Pharmaceuticals (Basel). 2021 Jul 22; 14(8). PMID: 34451805.
      View in: PubMed
    18. Cartwright IM, Dowdell AS, Lanis JM, Brink KR, Mu A, Kostelecky RE, Schaefer REM, Welch N, Onyiah JC, Hall CHT, Gerich ME, Tabor JJ, Colgan SP. Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation. Proc Natl Acad Sci U S A. 2021 05 18; 118(20). PMID: 33972436.
      View in: PubMed
    19. Alexeev EE, Dowdell AS, Henen MA, Lanis JM, Lee JS, Cartwright IM, Schaefer REM, Ornelas A, Onyiah JC, Vögeli B, Colgan SP. Microbial-derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage. FASEB J. 2021 05; 35(5):e21552. PMID: 33826788.
      View in: PubMed
    20. Dowdell AS, Cartwright IM, Goldberg MS, Kostelecky R, Ross T, Welch N, Glover LE, Colgan SP. The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis. Mol Biol Cell. 2020 09 15; 31(20):2249-2258. PMID: 32726170.
      View in: PubMed
    21. Dowdell AS, Murphy MD, Azodi C, Swanson SK, Florens L, Chen S, Zückert WR. Comprehensive Spatial Analysis of the Borrelia burgdorferi Lipoproteome Reveals a Compartmentalization Bias toward the Bacterial Surface. J Bacteriol. 2017 03 15; 199(6). PMID: 28069820.
      View in: PubMed
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