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Howard William Davidson

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BDC Basic Research
Phone303/724-6852

    Collapse Overview 
    Collapse overview
    The ultimate goal of research in my laboratory is to develop improved methods for measuring autoimmunity in type 1A diabetes, identify reagents that might have therapeutic utility for the prevention and/or treatment of this disease, and ultimately to translate this research to the clinic. Type 1A diabetes is a T-cell mediated autoimmune disease that results in an absolute deficiency of insulin following destruction of pancreatic beta cells. Consequently my research focuses on 2 major areas; auto-immunity to pancreatic beta cell proteins, and the cell biology of the pancreatic beta cell, with special emphasis on diabetes autoantigens. Current projects include the characterization of T-cells recognizing potentially diabetogenic epitopes in the auto-antigens IA-2, IA-2ß (phogrin), IGRP and ZnT8; use of pre-clinical rodent models to develop novel immune-therapies based on these targets; improving auto-antibody based prediction methods for type 1A diabetes risk; and development of novel “tetramer” based reagents for measuring human auto-antigen specific T-cells in peripheral blood. I am also interested in the functional and cell biological properties of IA-2, IA-2ß (phogrin), IGRP and ZnT8, and especially in determining why they are targeted by the immune system, and how defects in their function may contribute to type 2 diabetes. I am currently investigating the hypothesis that post-translational modifications unique to the beta cell create “neo-antigens” that are no subject to central tolerance. I also have a long-standing research interest in the basic cell biology of antigen processing and presentation, particularly in B lymphocytes, and how this might be harnessed for the development of novel antigen-specific therapies that might be applicable to the treatment and/or prevention of type 1 diabetes.

    Collapse Research 
    Collapse research activities and funding
    R21AI140044     (DAVIDSON, HOWARD W)Jan 15, 2019 - Dec 31, 2021
    NIH
    Stress induced changes to the human beta cell proteome
    Role: Principal Investigator

    R56AI091713     (DAVIDSON, HOWARD W)Aug 15, 2011 - Apr 30, 2013
    NIH
    Analysis of diabetogenic human T cell receptors
    Role: Principal Investigator

    R03AI090401     (DAVIDSON, HOWARD W)Jun 1, 2010 - Aug 31, 2012
    NIH
    Development of novel diabetes autoantibody assays based on luciferase reporters
    Role: Principal Investigator

    R21DK066043     (DAVIDSON, HOWARD W)Apr 1, 2005 - Mar 31, 2007
    NIH
    Active tolerosomes, a novel therapy for type 1 diabetes
    Role: Principal Investigator

    R01DK052068     (DAVIDSON, HOWARD W)Dec 14, 1996 - Mar 31, 2016
    NIH
    Cloning of molecular targets of Cell Mediated Autoimmunity in Type 1 Diabetes
    Role: Principal Investigator

    R56DK052068     (HUTTON, JOHN C)Dec 14, 1996 - Mar 31, 2011
    NIH
    Cloning of molecular targets of CMI in type 1 diabetes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Marzinotto I, Dottori L, Baldaro F, Dilaghi E, Brigatti C, Bazzigaluppi E, Esposito G, Davidson HW, Piemonti L, Lampasona V, Lahner E. Intrinsic factor autoantibodies by luminescent immuno-precipitation system in patients with corpus atrophic gastritis. J Transl Autoimmun. 2021; 4:100131. PMID: 35005595.
      View in: PubMed
    2. Russ HA, Davidson HW. Found in Translation: Novel Insights Into Type 1 Diabetes and ß-Cell Biology. Diabetes. 2021 10; 70(10):2185-2186. PMID: 34593539.
      View in: PubMed
    3. Kim YK, Sussel L, Davidson HW. Inherent Beta Cell Dysfunction Contributes to Autoimmune Susceptibility. Biomolecules. 2021 03 30; 11(4). PMID: 33808310.
      View in: PubMed
    4. Lahner E, Marzinotto I, Lampasona V, Dottori L, Bazzigaluppi E, Brigatti C, Secchi M, Piemonti L, Conti L, Pilozzi E, Davidson HW, Wenzlau JM, Annibale B. Autoantibodies Toward ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase Are Reliable Serological Pre-endoscopic Markers of Corpus Atrophic Gastritis. Clin Transl Gastroenterol. 2020 10; 11(10):e00240. PMID: 33031196.
      View in: PubMed
    5. Ghazvini Zadeh EH, Huang Z, Xia J, Li D, Davidson HW, Li WH. ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet a Cell Heterogeneity. Cell Rep. 2020 07 14; 32(2):107904. PMID: 32668245.
      View in: PubMed
    6. Davidson HW, Zhang L. Immune therapies for autoimmune diabetes targeting pathogenic peptide-MHC complexes. J Mol Cell Biol. 2020 01 10; 12(10):759-763. PMID: 32663282.
      View in: PubMed
    7. Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S. How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol. 2019 04 05; 4(34). PMID: 30952805.
      View in: PubMed
    8. Lahner E, Marzinotto I, Brigatti C, Davidson H, Wenzlau J, Piemonti L, Annibale B, Lampasona V. Measurement of Autoantibodies to Gastric H+,K+-ATPase (ATP4A/B) Using a Luciferase Immunoprecipitation System (LIPS). Methods Mol Biol. 2019; 1901:113-131. PMID: 30539573.
      View in: PubMed
    9. Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M. Development of T cell lines sensitive to antigen stimulation. J Immunol Methods. 2018 11; 462:65-73. PMID: 30165064.
      View in: PubMed
    10. Kozhakhmetova A, Wyatt RC, Caygill C, Williams C, Long AE, Chandler K, Aitken RJ, Wenzlau JM, Davidson HW, Gillespie KM, Williams AJK. A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study. Clin Exp Immunol. 2018 06; 192(3):251-258. PMID: 29431870.
      View in: PubMed
    11. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 28102858.
      View in: PubMed
    12. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 30122420.
      View in: PubMed
    13. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3283564.
      View in: PubMed
    14. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26405067.
      View in: PubMed
    15. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22069278.
      View in: PubMed
    16. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3318807.
      View in: PubMed
    17. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2120230.
      View in: PubMed
    18. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19120307.
      View in: PubMed
    19. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 10480952.
      View in: PubMed
    20. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 20035758.
      View in: PubMed
    21. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11581283.
      View in: PubMed
    22. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1913812.
      View in: PubMed
    23. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1447290.
      View in: PubMed
    24. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22983906.
      View in: PubMed
    25. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 20842762.
      View in: PubMed
    26. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19323954.
      View in: PubMed
    27. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22526607.
      View in: PubMed
    28. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18850084.
      View in: PubMed
    29. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21092458.
      View in: PubMed
    30. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2473083.
      View in: PubMed
    31. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19343319.
      View in: PubMed
    32. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19283733.
      View in: PubMed
    33. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2187925.
      View in: PubMed
    34. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8382697.
      View in: PubMed
    35. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18591387.
      View in: PubMed
    36. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7642698.
      View in: PubMed
    37. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3311030.
      View in: PubMed
    38. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 31167877.
      View in: PubMed
    39. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 31475985.
      View in: PubMed
    40. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33151102.
      View in: PubMed
    41. Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Sci Immunol. 2018 02 02; 3(20). PMID: 29429978.
      View in: PubMed
    42. James EA, Abreu JRF, McGinty JW, Odegard JM, Fillié YE, Hocter CN, Culina S, Ladell K, Price DA, Alkanani A, Rihanek M, Fitzgerald-Miller L, Skowera A, Speake C, Gottlieb P, Davidson HW, Wong FS, Roep B, Mallone R. Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop. Diabetologia. 2018 03; 61(3):658-670. PMID: 29196783.
      View in: PubMed
    43. Chobot A, Rusak E, Wenzlau J, Davidson H, Adamczyk P, Krzywicka A, Mazur B, Polanska J, Rewers M. ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12. Pediatr Diabetes. 2018 02; 19(1):80-84. PMID: 28401620.
      View in: PubMed
    44. Xu X, Gu Y, Bian L, Shi Y, Cai Y, Chen Y, Chen H, Qian L, Wu X, Xu K, Mallone R, Davidson HW, Yu L, She J, Zhang M, Yang T. Characterization of immune response to novel HLA-A2-restricted epitopes from zinc transporter 8 in type 1 diabetes. Vaccine. 2016 Feb 03; 34(6):854-62. PMID: 26541133.
      View in: PubMed
    45. Nakayama M, McDaniel K, Fitzgerald-Miller L, Kiekhaefer C, Snell-Bergeon JK, Davidson HW, Rewers M, Yu L, Gottlieb P, Kappler JW, Michels A. Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4429-34. PMID: 25831495.
      View in: PubMed
    46. Demeester S, Keymeulen B, Kaufman L, Van Dalem A, Balti EV, Van de Velde U, Goubert P, Verhaeghen K, Davidson HW, Wenzlau JM, Weets I, Pipeleers DG, Gorus FK. Preexisting insulin autoantibodies predict efficacy of otelixizumab in preserving residual ß-cell function in recent-onset type 1 diabetes. Diabetes Care. 2015 Apr; 38(4):644-51. PMID: 25583753.
      View in: PubMed
    47. Yang J, Chow IT, Sosinowski T, Torres-Chinn N, Greenbaum CJ, James EA, Kappler JW, Davidson HW, Kwok WW. Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14840-5. PMID: 25267644.
      View in: PubMed
    48. Davidson HW, Wenzlau JM, O'Brien RM. Zinc transporter 8 (ZnT8) and ß cell function. Trends Endocrinol Metab. 2014 Aug; 25(8):415-24. PMID: 24751356.
      View in: PubMed
    49. Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS. Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2656-61. PMID: 24550292.
      View in: PubMed
    50. Beyan H, Riese H, Hawa MI, Beretta G, Davidson HW, Hutton JC, Burger H, Schlosser M, Snieder H, Boehm BO, Leslie RD. Glycotoxin and autoantibodies are additive environmentally determined predictors of type 1 diabetes: a twin and population study. Diabetes. 2012 May; 61(5):1192-8. PMID: 22396204.
      View in: PubMed
    51. Wenzlau JM, Gardner TJ, Frisch LM, Davidson HW, Hutton JC. Development of a novel autoantibody assay for autoimmune gastritis in type 1 diabetic individuals. Diabetes Metab Res Rev. 2011 Nov; 27(8):887-90. PMID: 22069279.
      View in: PubMed
    52. Dang M, Rockell J, Wagner R, Wenzlau JM, Yu L, Hutton JC, Gottlieb PA, Davidson HW. Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8. J Immunol. 2011 May 15; 186(10):6056-63. PMID: 21471440.
      View in: PubMed
    53. Wenzlau JM, Walter M, Gardner TJ, Frisch LM, Yu L, Eisenbarth GS, Ziegler AG, Davidson HW, Hutton JC. Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects. J Clin Endocrinol Metab. 2010 Oct; 95(10):4712-9. PMID: 20610599.
      View in: PubMed
    54. Hutton JC, Davidson HW. Getting beta all the time: discovery of reliable markers of beta cell mass. Diabetologia. 2010 Jul; 53(7):1254-7. PMID: 20411233.
      View in: PubMed
    55. Hutton JC, Davidson HW. Cytokine-induced dicing and splicing in the beta-cell and the immune response in type 1 diabetes. Diabetes. 2010 Feb; 59(2):335-6. PMID: 20103713.
      View in: PubMed
    56. Zhang L, Jasinski JM, Kobayashi M, Davenport B, Johnson K, Davidson H, Nakayama M, Haskins K, Eisenbarth GS. Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains. J Autoimmun. 2009 Aug; 33(1):42-9. PMID: 19286348.
      View in: PubMed
    57. Liu Y, Wenzlau JM, Yu L, Patel C, Eisenbarth GS, Hutton JC, Davidson HW. Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigens. Ann N Y Acad Sci. 2008 Dec; 1150:245-7. PMID: 19120304.
      View in: PubMed
    58. Wenzlau JM, Moua O, Liu Y, Eisenbarth GS, Hutton JC, Davidson HW. Identification of a major humoral epitope in Slc30A8 (ZnT8). Ann N Y Acad Sci. 2008 Dec; 1150:252-5. PMID: 19120306.
      View in: PubMed
    59. Wenzlau JM, Hutton JC, Davidson HW. New antigenic targets in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2008 Aug; 15(4):315-20. PMID: 18594270.
      View in: PubMed
    60. Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17040-5. PMID: 17942684.
      View in: PubMed
    61. Sarkar SA, Wong R, Hackl SI, Moua O, Gill RG, Wiseman A, Davidson HW, Hutton JC. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. Diabetes. 2007 Jan; 56(1):72-9. PMID: 17192467.
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    62. Wasmeier C, Burgos PV, Trudeau T, Davidson HW, Hutton JC. An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin. Traffic. 2005 Jun; 6(6):474-87. PMID: 15882444.
      View in: PubMed
    63. Cook NR, Row PE, Davidson HW. Lysosome associated membrane protein 1 (Lamp1) traffics directly from the TGN to early endosomes. Traffic. 2004 Sep; 5(9):685-99. PMID: 15296493.
      View in: PubMed
    64. Kelemen K, Gottlieb PA, Putnam AL, Davidson HW, Wegmann DR, Hutton JC. HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes. J Immunol. 2004 Mar 15; 172(6):3955-62. PMID: 15004204.
      View in: PubMed
    65. Davidson HW. (Pro)Insulin processing: a historical perspective. Cell Biochem Biophys. 2004; 40(3 Suppl):143-58. PMID: 15289650.
      View in: PubMed
    66. Scott CC, Cuellar-Mata P, Matsuo T, Davidson HW, Grinstein S. Role of 3-phosphoinositides in the maturation of Salmonella-containing vacuoles within host cells. J Biol Chem. 2002 Apr 12; 277(15):12770-6. PMID: 11821391.
      View in: PubMed
    67. Row PE, Reaves BJ, Domin J, Luzio JP, Davidson HW. Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation. Biochem J. 2001 Feb 01; 353(Pt 3):655-61. PMID: 11171063.
      View in: PubMed
    68. Cook NR, Davidson HW. In vitro assays of vesicular transport. Traffic. 2001 Jan; 2(1):19-25. PMID: 11208165.
      View in: PubMed
    69. Reaves BJ, Row PE, Bright NA, Luzio JP, Davidson HW. Loss of cation-independent mannose 6-phosphate receptor expression promotes the accumulation of lysobisphosphatidic acid in multilamellar bodies. J Cell Sci. 2000 Nov; 113 ( Pt 22):4099-108. PMID: 11058096.
      View in: PubMed
    70. Shepherd PR, Reaves BJ, Davidson HW. Phosphoinositide 3-kinases and membrane traffic. Trends Cell Biol. 1996 Mar; 6(3):92-7. PMID: 15157484.
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    71. Nuoffer C, Davidson HW, Matteson J, Meinkoth J, Balch WE. A GDP-bound of rab1 inhibits protein export from the endoplasmic reticulum and transport between Golgi compartments. J Cell Biol. 1994 Apr; 125(2):225-37. PMID: 8163542.
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    72. Pind SN, Nuoffer C, McCaffery JM, Plutner H, Davidson HW, Farquhar MG, Balch WE. Rab1 and Ca2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport. J Cell Biol. 1994 Apr; 125(2):239-52. PMID: 8163543.
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    73. Pind S, Davidson H, Schwaninger R, Beckers CJ, Plutner H, Schmid SL, Balch WE. Preparation of semiintact cells for study of vesicular trafficking in vitro. Methods Enzymol. 1993; 221:222-34. PMID: 8395634.
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    74. Davidson HW, McGowan CH, Balch WE. Evidence for the regulation of exocytic transport by protein phosphorylation. J Cell Biol. 1992 Mar; 116(6):1343-55. PMID: 1311711.
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    75. Davidson HW, Balch WE. Use of two-stage incubations to define sequential intermediates in endoplasmic reticulum to Golgi transport. Methods Enzymol. 1992; 219:261-7. PMID: 1487999.
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    76. Schwaninger R, Plutner H, Davidson HW, Pind S, Balch WE. Transport of protein between endoplasmic reticulum and Golgi compartments in semiintact cells. Methods Enzymol. 1992; 219:110-24. PMID: 1336806.
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    77. Guest PC, Ravazzola M, Davidson HW, Orci L, Hutton JC. Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans. Endocrinology. 1991 Aug; 129(2):734-40. PMID: 1855471.
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    78. Watts C, Reid PA, West MA, Davidson HW. The antigen processing pathway in B lymphocytes. Semin Immunol. 1990 Jul; 2(4):247-53. PMID: 1983338.
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    79. Watts C, West MA, Reid PA, Davidson HW. Processing of immunoglobulin-associated antigen in B lymphocytes. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:345-52. PMID: 2484164.
      View in: PubMed
    80. Watts C, Davidson HW. Endocytosis and recycling of specific antigen by human B cell lines. EMBO J. 1988 Jul; 7(7):1937-45. PMID: 3262056.
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    81. Davidson HW, Hutton JC. The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. Biochem J. 1987 Jul 15; 245(2):575-82. PMID: 2822027.
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    82. Hutton JC, Davidson HW, Peshavaria M. Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC 3.4.17.10). Biochem J. 1987 Jun 01; 244(2):457-64. PMID: 2822006.
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    83. Hutton JC, Davidson HW, Peshavaria M. The mechanism of chromogranin A processing. Nature. 1987 Feb 26-Mar 4; 325(6107):766. PMID: 3821867.
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