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Howard William Davidson

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BDC Basic Research
Phone303/724-6852

    Collapse Overview 
    Collapse overview
    The ultimate goal of research in my laboratory is to develop improved methods for measuring autoimmunity in type 1A diabetes, identify reagents that might have therapeutic utility for the prevention and/or treatment of this disease, and ultimately to translate this research to the clinic. Type 1A diabetes is a T-cell mediated autoimmune disease that results in an absolute deficiency of insulin following destruction of pancreatic beta cells. Consequently my research focuses on 2 major areas; auto-immunity to pancreatic beta cell proteins, and the cell biology of the pancreatic beta cell, with special emphasis on diabetes autoantigens. Current projects include the characterization of T-cells recognizing potentially diabetogenic epitopes in the auto-antigens IA-2, IA-2ß (phogrin), IGRP and ZnT8; use of pre-clinical rodent models to develop novel immune-therapies based on these targets; improving auto-antibody based prediction methods for type 1A diabetes risk; and development of novel “tetramer” based reagents for measuring human auto-antigen specific T-cells in peripheral blood. I am also interested in the functional and cell biological properties of IA-2, IA-2ß (phogrin), IGRP and ZnT8, and especially in determining why they are targeted by the immune system, and how defects in their function may contribute to type 2 diabetes. I am currently investigating the hypothesis that post-translational modifications unique to the beta cell create “neo-antigens” that are no subject to central tolerance. I also have a long-standing research interest in the basic cell biology of antigen processing and presentation, particularly in B lymphocytes, and how this might be harnessed for the development of novel antigen-specific therapies that might be applicable to the treatment and/or prevention of type 1 diabetes.

    Collapse Research 
    Collapse research activities and funding
    R56DK052068     (HUTTON, JOHN C)Dec 14, 1996 - Mar 31, 2011
    NIH
    Cloning of molecular targets of CMI in type 1 diabetes
    Role: Principal Investigator
    R01DK052068     (DAVIDSON, HOWARD W)Dec 14, 1996 - Mar 31, 2016
    NIH
    Cloning of molecular targets of Cell Mediated Autoimmunity in Type 1 Diabetes
    Role: Principal Investigator
    R21DK066043     (DAVIDSON, HOWARD W)Apr 1, 2005 - Mar 31, 2007
    NIH
    Active tolerosomes, a novel therapy for type 1 diabetes
    Role: Principal Investigator
    R03AI090401     (DAVIDSON, HOWARD W)Jun 1, 2010 - Aug 31, 2012
    NIH
    Development of novel diabetes autoantibody assays based on luciferase reporters
    Role: Principal Investigator
    R56AI091713     (DAVIDSON, HOWARD W)Aug 15, 2011 - Apr 30, 2013
    NIH
    Analysis of diabetogenic human T cell receptors
    Role: Principal Investigator
    R21AI140044     (DAVIDSON, HOWARD W)Jan 15, 2019 - Dec 31, 2021
    NIH
    Stress induced changes to the human beta cell proteome
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kim YK, Sussel L, Davidson HW. Inherent Beta Cell Dysfunction Contributes to Autoimmune Susceptibility. Biomolecules. 2021 03 30; 11(4). PMID: 33808310.
      View in: PubMed
    2. Lahner E, Marzinotto I, Lampasona V, Dottori L, Bazzigaluppi E, Brigatti C, Secchi M, Piemonti L, Conti L, Pilozzi E, Davidson HW, Wenzlau JM, Annibale B. Autoantibodies Toward ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase Are Reliable Serological Pre-endoscopic Markers of Corpus Atrophic Gastritis. Clin Transl Gastroenterol. 2020 10; 11(10):e00240. PMID: 33031196.
      View in: PubMed
    3. Ghazvini Zadeh EH, Huang Z, Xia J, Li D, Davidson HW, Li WH. ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet a Cell Heterogeneity. Cell Rep. 2020 07 14; 32(2):107904. PMID: 32668245.
      View in: PubMed
    4. Davidson HW, Zhang L. Immune therapies for autoimmune diabetes targeting pathogenic peptide-MHC complexes. J Mol Cell Biol. 2020 01 10; 12(10):759-763. PMID: 32663282.
      View in: PubMed
    5. Cepeda JR, Sekhar NS, Han J, Xiong W, Zhang N, Yu L, Dai S, Davidson HW, Kappler JW, An Z, Zhang L. A monoclonal antibody with broad specificity for the ligands of insulin B:9-23 reactive T cells prevents spontaneous type 1 diabetes in mice. MAbs. 2020 Jan-Dec; 12(1):1836714. PMID: 33151102.
      View in: PubMed
    6. Davidson HW, Cepeda JR, Sekhar NS, Han J, Gao L, Sosinowski T, Zhang L. High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model. J Vis Exp. 2019 08 16; (150). PMID: 31475985.
      View in: PubMed
    7. Acevedo-Calado MJ, Pietropaolo SL, Morran MP, Schnell S, Vonberg AD, Verge CF, Gianani R, Becker DJ, Huang S, Greenbaum CJ, Yu L, Davidson HW, Michels AW, Rich SS, Pietropaolo M. Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes. Diabetes. 2019 09; 68(9):1819-1829. PMID: 31167877.
      View in: PubMed
    8. Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S. How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol. 2019 04 05; 4(34). PMID: 30952805.
      View in: PubMed
    9. Lahner E, Marzinotto I, Brigatti C, Davidson H, Wenzlau J, Piemonti L, Annibale B, Lampasona V. Measurement of Autoantibodies to Gastric H+,K+-ATPase (ATP4A/B) Using a Luciferase Immunoprecipitation System (LIPS). Methods Mol Biol. 2019; 1901:113-131. PMID: 30539573.
      View in: PubMed
    10. Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M. Development of T cell lines sensitive to antigen stimulation. J Immunol Methods. 2018 11; 462:65-73. PMID: 30165064.
      View in: PubMed
    11. Zhang L, Sosinowski T, Cox AR, Cepeda JR, Sekhar NS, Hartig SM, Miao D, Yu L, Pietropaolo M, Davidson HW. Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes. J Autoimmun. 2019 01; 96:50-58. PMID: 30122420.
      View in: PubMed
    12. Kozhakhmetova A, Wyatt RC, Caygill C, Williams C, Long AE, Chandler K, Aitken RJ, Wenzlau JM, Davidson HW, Gillespie KM, Williams AJK. A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study. Clin Exp Immunol. 2018 06; 192(3):251-258. PMID: 29431870.
      View in: PubMed
    13. Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Sci Immunol. 2018 02 02; 3(20). PMID: 29429978.
      View in: PubMed
    14. James EA, Abreu JRF, McGinty JW, Odegard JM, Fillié YE, Hocter CN, Culina S, Ladell K, Price DA, Alkanani A, Rihanek M, Fitzgerald-Miller L, Skowera A, Speake C, Gottlieb P, Davidson HW, Wong FS, Roep B, Mallone R. Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop. Diabetologia. 2018 03; 61(3):658-670. PMID: 29196783.
      View in: PubMed
    15. Chobot A, Rusak E, Wenzlau J, Davidson H, Adamczyk P, Krzywicka A, Mazur B, Polanska J, Rewers M. ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12. Pediatr Diabetes. 2018 02; 19(1):80-84. PMID: 28401620.
      View in: PubMed
    16. Lahner E, Brigatti C, Marzinotto I, Carabotti M, Scalese G, Davidson HW, Wenzlau JM, Bosi E, Piemonti L, Annibale B, Lampasona V. Luminescent Immunoprecipitation System (LIPS) for Detection of Autoantibodies Against ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase in Atrophic Body Gastritis Patients. Clin Transl Gastroenterol. 2017 Jan 19; 8(1):e215. PMID: 28102858.
      View in: PubMed
    17. Xu X, Gu Y, Bian L, Shi Y, Cai Y, Chen Y, Chen H, Qian L, Wu X, Xu K, Mallone R, Davidson HW, Yu L, She J, Zhang M, Yang T. Characterization of immune response to novel HLA-A2-restricted epitopes from zinc transporter 8 in type 1 diabetes. Vaccine. 2016 Feb 03; 34(6):854-62. PMID: 26541133.
      View in: PubMed
    18. Wenzlau JM, Frisch LM, Hutton JC, Fain PR, Davidson HW. Changes in Zinc Transporter 8 Autoantibodies Following Type 1 Diabetes Onset: The Type 1 Diabetes Genetics Consortium Autoantibody Workshop. Diabetes Care. 2015 Oct; 38 Suppl 2:S14-20. PMID: 26405067.
      View in: PubMed
    19. Nakayama M, McDaniel K, Fitzgerald-Miller L, Kiekhaefer C, Snell-Bergeon JK, Davidson HW, Rewers M, Yu L, Gottlieb P, Kappler JW, Michels A. Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4429-34. PMID: 25831495.
      View in: PubMed
    20. Demeester S, Keymeulen B, Kaufman L, Van Dalem A, Balti EV, Van de Velde U, Goubert P, Verhaeghen K, Davidson HW, Wenzlau JM, Weets I, Pipeleers DG, Gorus FK. Preexisting insulin autoantibodies predict efficacy of otelixizumab in preserving residual ß-cell function in recent-onset type 1 diabetes. Diabetes Care. 2015 Apr; 38(4):644-51. PMID: 25583753.
      View in: PubMed
    21. Yang J, Chow IT, Sosinowski T, Torres-Chinn N, Greenbaum CJ, James EA, Kappler JW, Davidson HW, Kwok WW. Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14840-5. PMID: 25267644.
      View in: PubMed
    22. Davidson HW, Wenzlau JM, O'Brien RM. Zinc transporter 8 (ZnT8) and ß cell function. Trends Endocrinol Metab. 2014 Aug; 25(8):415-24. PMID: 24751356.
      View in: PubMed
    23. Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS. Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2656-61. PMID: 24550292.
      View in: PubMed
    24. Yang T, Hohenstein AC, Lee CE, Hutton JC, Davidson HW. Mapping I-A(g7) restricted epitopes in murine G6PC2. Immunol Res. 2013 Mar; 55(1-3):91-9. PMID: 22983906.
      View in: PubMed
    25. Scotto M, Afonso G, Larger E, Raverdy C, Lemonnier FA, Carel JC, Dubois-Laforgue D, Baz B, Levy D, Gautier JF, Launay O, Bruno G, Boitard C, Sechi LA, Hutton JC, Davidson HW, Mallone R. Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients. Diabetologia. 2012 Jul; 55(7):2026-31. PMID: 22526607.
      View in: PubMed
    26. Beyan H, Riese H, Hawa MI, Beretta G, Davidson HW, Hutton JC, Burger H, Schlosser M, Snieder H, Boehm BO, Leslie RD. Glycotoxin and autoantibodies are additive environmentally determined predictors of type 1 diabetes: a twin and population study. Diabetes. 2012 May; 61(5):1192-8. PMID: 22396204.
      View in: PubMed
    27. Wenzlau JM, Frisch LM, Hutton JC, Davidson HW. Mapping of conformational autoantibody epitopes in ZNT8. Diabetes Metab Res Rev. 2011 Nov; 27(8):883-6. PMID: 22069278.
      View in: PubMed
    28. Wenzlau JM, Gardner TJ, Frisch LM, Davidson HW, Hutton JC. Development of a novel autoantibody assay for autoimmune gastritis in type 1 diabetic individuals. Diabetes Metab Res Rev. 2011 Nov; 27(8):887-90. PMID: 22069279.
      View in: PubMed
    29. Dang M, Rockell J, Wagner R, Wenzlau JM, Yu L, Hutton JC, Gottlieb PA, Davidson HW. Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8. J Immunol. 2011 May 15; 186(10):6056-63. PMID: 21471440.
      View in: PubMed
    30. Yang L, Luo S, Huang G, Peng J, Li X, Yan X, Lin J, Wenzlau JM, Davidson HW, Hutton JC, Zhou Z. The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese. Diabetes Metab Res Rev. 2010 Oct; 26(7):579-84. PMID: 20842762.
      View in: PubMed
    31. YANG L, LUO SM, HUANG G, PENG J, YAN X, WENZLAU J, DAVIDSON HW, HUTTON JC, ZHOU ZG. [Value of zinc transporter 8 autoantibody in the diagnostic classification of acute-onset diabetics]. Zhonghua Yi Xue Za Zhi. 2010 Sep 28; 90(36):2536-40. PMID: 21092458.
      View in: PubMed
    32. Wenzlau JM, Walter M, Gardner TJ, Frisch LM, Yu L, Eisenbarth GS, Ziegler AG, Davidson HW, Hutton JC. Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects. J Clin Endocrinol Metab. 2010 Oct; 95(10):4712-9. PMID: 20610599.
      View in: PubMed
    33. Hutton JC, Davidson HW. Getting beta all the time: discovery of reliable markers of beta cell mass. Diabetologia. 2010 Jul; 53(7):1254-7. PMID: 20411233.
      View in: PubMed
    34. Hutton JC, Davidson HW. Cytokine-induced dicing and splicing in the beta-cell and the immune response in type 1 diabetes. Diabetes. 2010 Feb; 59(2):335-6. PMID: 20103713.
      View in: PubMed
    35. Yu L, Liu Y, Miao D, Wenzlau J, Davidson H, Hutton J, Eisenbarth GS. Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination. J Immunol Methods. 2010 Feb 28; 353(1-2):20-3. PMID: 20035758.
      View in: PubMed
    36. Sarkar SA, Kutlu B, Velmurugan K, Kizaka-Kondoh S, Lee CE, Wong R, Valentine A, Davidson HW, Hutton JC, Pugazhenthi S. Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line. Diabetologia. 2009 Jun; 52(6):1092-101. PMID: 19343319.
      View in: PubMed
    37. Wenzlau JM, Frisch LM, Gardner TJ, Sarkar S, Hutton JC, Davidson HW. Novel antigens in type 1 diabetes: the importance of ZnT8. Curr Diab Rep. 2009 Apr; 9(2):105-12. PMID: 19323954.
      View in: PubMed
    38. Zhang L, Jasinski JM, Kobayashi M, Davenport B, Johnson K, Davidson H, Nakayama M, Haskins K, Eisenbarth GS. Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains. J Autoimmun. 2009 Aug; 33(1):42-9. PMID: 19286348.
      View in: PubMed
    39. Hutton JC, Wong R, Davidson HW. Isolation of dense core secretory vesicles from pancreatic endocrine cells by differential and density gradient centrifugation. Curr Protoc Cell Biol. 2009 Mar; Chapter 3:Unit 3.32. PMID: 19283733.
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    40. Wenzlau JM, Moua O, Liu Y, Eisenbarth GS, Hutton JC, Davidson HW. Identification of a major humoral epitope in Slc30A8 (ZnT8). Ann N Y Acad Sci. 2008 Dec; 1150:252-5. PMID: 19120306.
      View in: PubMed
    41. Liu Y, Wenzlau JM, Yu L, Patel C, Eisenbarth GS, Hutton JC, Davidson HW. Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigens. Ann N Y Acad Sci. 2008 Dec; 1150:245-7. PMID: 19120304.
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    42. Wenzlau JM, Moua O, Sarkar SA, Yu L, Rewers M, Eisenbarth GS, Davidson HW, Hutton JC. SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes. Ann N Y Acad Sci. 2008 Dec; 1150:256-9. PMID: 19120307.
      View in: PubMed
    43. Kawasaki E, Uga M, Nakamura K, Kuriya G, Satoh T, Fujishima K, Ozaki M, Abiru N, Yamasaki H, Wenzlau JM, Davidson HW, Hutton JC, Eguchi K. Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes. Diabetologia. 2008 Dec; 51(12):2299-302. PMID: 18850084.
      View in: PubMed
    44. Wenzlau JM, Hutton JC, Davidson HW. New antigenic targets in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2008 Aug; 15(4):315-20. PMID: 18594270.
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    45. Wenzlau JM, Liu Y, Yu L, Moua O, Fowler KT, Rangasamy S, Walters J, Eisenbarth GS, Davidson HW, Hutton JC. A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. Diabetes. 2008 Oct; 57(10):2693-7. PMID: 18591387.
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    46. Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17040-5. PMID: 17942684.
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    47. Sarkar SA, Wong R, Hackl SI, Moua O, Gill RG, Wiseman A, Davidson HW, Hutton JC. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. Diabetes. 2007 Jan; 56(1):72-9. PMID: 17192467.
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    48. Wasmeier C, Burgos PV, Trudeau T, Davidson HW, Hutton JC. An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin. Traffic. 2005 Jun; 6(6):474-87. PMID: 15882444.
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    49. Cook NR, Row PE, Davidson HW. Lysosome associated membrane protein 1 (Lamp1) traffics directly from the TGN to early endosomes. Traffic. 2004 Sep; 5(9):685-99. PMID: 15296493.
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    50. Kelemen K, Gottlieb PA, Putnam AL, Davidson HW, Wegmann DR, Hutton JC. HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes. J Immunol. 2004 Mar 15; 172(6):3955-62. PMID: 15004204.
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    51. Davidson HW. (Pro)Insulin processing: a historical perspective. Cell Biochem Biophys. 2004; 40(3 Suppl):143-58. PMID: 15289650.
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    52. Scott CC, Cuellar-Mata P, Matsuo T, Davidson HW, Grinstein S. Role of 3-phosphoinositides in the maturation of Salmonella-containing vacuoles within host cells. J Biol Chem. 2002 Apr 12; 277(15):12770-6. PMID: 11821391.
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    53. Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol. 2001 Oct 01; 155(1):19-25. PMID: 11581283.
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    54. Row PE, Reaves BJ, Domin J, Luzio JP, Davidson HW. Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation. Biochem J. 2001 Feb 01; 353(Pt 3):655-61. PMID: 11171063.
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    55. Cook NR, Davidson HW. In vitro assays of vesicular transport. Traffic. 2001 Jan; 2(1):19-25. PMID: 11208165.
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    56. Reaves BJ, Row PE, Bright NA, Luzio JP, Davidson HW. Loss of cation-independent mannose 6-phosphate receptor expression promotes the accumulation of lysobisphosphatidic acid in multilamellar bodies. J Cell Sci. 2000 Nov; 113 ( Pt 22):4099-108. PMID: 11058096.
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    57. Davidson HW. Direct transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimera. J Biol Chem. 1999 Sep 17; 274(38):27315-22. PMID: 10480952.
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    58. Shepherd PR, Reaves BJ, Davidson HW. Phosphoinositide 3-kinases and membrane traffic. Trends Cell Biol. 1996 Mar; 6(3):92-7. PMID: 15157484.
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    59. Davidson HW. Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes. J Cell Biol. 1995 Aug; 130(4):797-805. PMID: 7642698.
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    60. Pind SN, Nuoffer C, McCaffery JM, Plutner H, Davidson HW, Farquhar MG, Balch WE. Rab1 and Ca2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport. J Cell Biol. 1994 Apr; 125(2):239-52. PMID: 8163543.
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    61. Nuoffer C, Davidson HW, Matteson J, Meinkoth J, Balch WE. A GDP-bound of rab1 inhibits protein export from the endoplasmic reticulum and transport between Golgi compartments. J Cell Biol. 1994 Apr; 125(2):225-37. PMID: 8163542.
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    62. Davidson HW, Balch WE. Differential inhibition of multiple vesicular transport steps between the endoplasmic reticulum and trans Golgi network. J Biol Chem. 1993 Feb 25; 268(6):4216-26. PMID: 8382697.
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    63. Pind S, Davidson H, Schwaninger R, Beckers CJ, Plutner H, Schmid SL, Balch WE. Preparation of semiintact cells for study of vesicular trafficking in vitro. Methods Enzymol. 1993; 221:222-34. PMID: 8395634.
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    64. Plutner H, Davidson HW, Saraste J, Balch WE. Morphological analysis of protein transport from the ER to Golgi membranes in digitonin-permeabilized cells: role of the P58 containing compartment. J Cell Biol. 1992 Dec; 119(5):1097-116. PMID: 1447290.
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    65. Davidson HW, McGowan CH, Balch WE. Evidence for the regulation of exocytic transport by protein phosphorylation. J Cell Biol. 1992 Mar; 116(6):1343-55. PMID: 1311711.
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    66. Schwaninger R, Plutner H, Davidson HW, Pind S, Balch WE. Transport of protein between endoplasmic reticulum and Golgi compartments in semiintact cells. Methods Enzymol. 1992; 219:110-24. PMID: 1336806.
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    67. Davidson HW, Balch WE. Use of two-stage incubations to define sequential intermediates in endoplasmic reticulum to Golgi transport. Methods Enzymol. 1992; 219:261-7. PMID: 1487999.
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    68. Davidson HW, Reid PA, Lanzavecchia A, Watts C. Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes. Cell. 1991 Oct 04; 67(1):105-16. PMID: 1913812.
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    69. Guest PC, Ravazzola M, Davidson HW, Orci L, Hutton JC. Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans. Endocrinology. 1991 Aug; 129(2):734-40. PMID: 1855471.
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    70. Beckers CJ, Plutner H, Davidson HW, Balch WE. Sequential intermediates in the transport of protein between the endoplasmic reticulum and the Golgi. J Biol Chem. 1990 Oct 25; 265(30):18298-310. PMID: 2120230.
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    71. Watts C, Reid PA, West MA, Davidson HW. The antigen processing pathway in B lymphocytes. Semin Immunol. 1990 Jul; 2(4):247-53. PMID: 1983338.
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    72. Davidson HW, West MA, Watts C. Endocytosis, intracellular trafficking, and processing of membrane IgG and monovalent antigen/membrane IgG complexes in B lymphocytes. J Immunol. 1990 Jun 01; 144(11):4101-9. PMID: 2187925.
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    73. Davidson HW, Watts C. Epitope-directed processing of specific antigen by B lymphocytes. J Cell Biol. 1989 Jul; 109(1):85-92. PMID: 2473083.
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    74. Watts C, West MA, Reid PA, Davidson HW. Processing of immunoglobulin-associated antigen in B lymphocytes. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:345-52. PMID: 2484164.
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    75. Watts C, Davidson HW. Endocytosis and recycling of specific antigen by human B cell lines. EMBO J. 1988 Jul; 7(7):1937-45. PMID: 3262056.
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    76. Davidson HW, Rhodes CJ, Hutton JC. Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases. Nature. 1988 May 05; 333(6168):93-6. PMID: 3283564.
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    77. Davidson HW, Peshavaria M, Hutton JC. Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules. Biochem J. 1987 Sep 01; 246(2):279-86. PMID: 3318807.
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    78. Davidson HW, Hutton JC. The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. Biochem J. 1987 Jul 15; 245(2):575-82. PMID: 2822027.
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    79. Hutton JC, Davidson HW, Peshavaria M. Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC 3.4.17.10). Biochem J. 1987 Jun 01; 244(2):457-64. PMID: 2822006.
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    80. Hutton JC, Davidson HW, Grimaldi KA, Peshavaria M. Biosynthesis of betagranin in pancreatic beta-cells. Identification of a chromogranin A-like precursor and its parallel processing with proinsulin. Biochem J. 1987 Jun 01; 244(2):449-56. PMID: 3311030.
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    81. Hutton JC, Davidson HW, Peshavaria M. The mechanism of chromogranin A processing. Nature. 1987 Feb 26-Mar 4; 325(6107):766. PMID: 3821867.
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