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Timothy A. Benke

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
    Other Positions
    TitleDirector-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-PEDS
    DivisionNeurology


    Collapse Research 
    Collapse research activities and funding
    U24NS133991     (BENNETT, JEFFREY L)Jul 15, 2023 - Jun 30, 2028
    NIH
    University of Colorado Rocky Mountain NeuroNEXT (UNCOMON) Clinical Research Consortium.
    Role: Co-Principal Investigator
    U01NS114312     (BENKE, TIMOTHY A)Feb 15, 2021 - Jan 31, 2026
    NIH
    Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder
    Role: Principal Investigator
    R21NS112770     (BENKE, TIMOTHY A)Apr 1, 2020 - Sep 30, 2021
    NIH
    Pilot studies to characterize CDKL5 inhibitors
    Role: Principal Investigator
    R21NS101288     (BENKE, TIMOTHY A)Sep 15, 2017 - Aug 31, 2021
    NIH
    Exploratory determination of the role of L-type calcium channels in mediating abnormal plasticity and behavior after early life seizures
    Role: Principal Investigator
    K12NS089417     (BROOKS-KAYAL, AMY R.)Jul 1, 2015 - Jun 30, 2020
    NIH
    Colorado Neurological Sciences Academic Development Award (NSADA)
    Role: Co-Principal Investigator
    U10NS077277     (VOLLMER, TIMOTHY LEE)Sep 30, 2011 - Dec 31, 2019
    NIH
    Rocky Mountain Network for Neuroscience Clinical Studies (RMNNCS)
    Role: Co-Principal Investigator
    R01NS076577     (BENKE, TIMOTHY A)Sep 1, 2011 - Jun 30, 2017
    NIH
    Molecular mechanisms linking early life seizures, autism and intellectual disabil
    Role: Principal Investigator
    K02NS056090     (BENKE, TIMOTHY A)May 1, 2007 - Apr 30, 2012
    NIH
    Impact of early life seizures on glutamate receptors and synaptic function
    Role: Principal Investigator
    K08NS041267     (BENKE, TIMOTHY A)Sep 6, 2001 - Aug 31, 2007
    NIH
    Impact of Early-Life Seizures on Synaptic Plasticity
    Role: Principal Investigator
    F32NS009894     (BENKE, TIMOTHY A)Dec 1, 1995
    NIH
    PHARMACOLOGICAL DENDRITIC GLUTAMATE CHANGES IN LTP
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kranz D, Braverman Y, McCarthy M, Mackay C, Sabol KN, Benke TA, Lieberman DN, Marsh ED, Neul JL, Peck F, Percy AK, Saby J, Kopell N, Nelson CA, Levin AR, Fagiolini M. Altered oscillatory coupling reflects possible inhibitory interneuron dysfunction in Rett syndrome. medRxiv. 2025 Oct 06. PMID: 40778166.
      View in: PubMed
    2. Keeley J, Skoda Z, Utley K, Marsh ED, Conecker GA, Hecker J, Ludwig NN, Leonard H, Saldaris J, Jacoby P, Pincus S, Benke TA, Demarest ST, Downs J. Parent/caregiver perspectives of meaningful improvement in functional domains for people with CDKL5 deficiency disorder: a mixed-methods study. Qual Life Res. 2025 Sep 09. PMID: 40924387.
      View in: PubMed
    3. Keeley J, Saldaris J, Benson-Goldberg S, Lariviere J, Leonard H, Marsh ED, Demarest ST, Benke TA, Jacoby P, Downs J. Content Validation of the Communication Inventory Disability-Observer Reported (CID-OR). J Child Neurol. 2025 Sep 03; 8830738251369138. PMID: 40900005.
      View in: PubMed
    4. Boeri S, Piai M, Russo S, Alari V, Cogliati F, Simonetta D, Benke TA, Nobili L, Prato G. Clinical differences in monozygotic twins with Rett syndrome: case report and systematic review. Orphanet J Rare Dis. 2025 Sep 02; 20(1):473. PMID: 40898246.
      View in: PubMed
    5. Rhodes C, Rees B, Dubbs H, Lesser M, Morgan L, Benke TA, Percy A, Neul JL, Marsh ED. Natural history of epilepsy in FOXG1 Syndrome. Epilepsy Res. 2025 Aug 26; 218:107644. PMID: 40882535.
      View in: PubMed
    6. Abbott M, Angione K, Stringfellow M, Malik K, Saenz M, McCourt E, Silveira L, Miele A, Benke TA, Demarest S. Cortical Visual Impairment Across a Range of Neurodevelopmental Disorders: Clinical Characterization, Diagnostic Tool Evaluation, and Association with Developmental Outcomes. J Child Neurol. 2025 Aug 06; 8830738251361698. PMID: 40767165.
      View in: PubMed
    7. Camp CR, Banke TG, Xing H, Yu K, Perszyk RE, Epplin MP, Akins NS, Zhang J, Benke TA, Yuan H, Liotta DC, Traynelis SF. Selective enhancement of the interneuron network and gamma-band power via GluN2C/GluN2D NMDA receptor potentiation. J Physiol. 2025 Jul; 603(14):4027-4049. PMID: 40560934.
      View in: PubMed
    8. Percy AK, Neul JL, Ananth A, Benke TA, Marsh ED. Symptom Onset in Classic Rett Syndrome: Analysis of Initial Clinical Severity Scale Entries. Ann Child Neurol Soc. 2025 Jun 16. PMID: 40880843.
      View in: PubMed
    9. Thompson T, Gurfinkel D, Silveira L, Klamut N, Ferdinandsen K, Fu C, Ananth AL, Lane JB, Marsh ED, Neul JL, Percy AK, Benke TA. Medical Biases and Misconceptions Impact Diagnoses in Males With Loss of Function MECP2 Variants. Am J Med Genet A. 2025 Oct; 197(10):e64147. PMID: 40515634.
      View in: PubMed
    10. Bernard PB, Castano AM, Buonarati OR, Camp CR, Hell JW, Benke TA. Early life seizures chronically disrupt L-type voltage gated calcium channel regulation of mGluR mediated long term depression via interactions with protein phosphatase 2A. Neurobiol Dis. 2025 06 01; 209:106884. PMID: 40147739.
      View in: PubMed
    11. Percy AK, Ryther R, Marsh ED, Neul JL, Benke TA, Berry-Kravis EM, Feyma T, Lieberman DN, Ananth AL, Fu C, Buhrfiend C, Barrett A, Doshi D, Darwish M, An D, Bishop KM, Youakim JM. Results from the phase 2/3 DAFFODIL study of trofinetide in girls aged 2-4 years with Rett syndrome. Med. 2025 Jun 13; 6(6):100608. PMID: 40043705.
      View in: PubMed
    12. Campbell K, Neul JL, Lieberman DN, Berry-Kravis E, Benke TA, Fu C, Percy A, Suter B, Morris D, Carpenter RL, Marsh ED, von Hehn J. A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome. J Neurodev Disord. 2025 Jan 24; 17(1):4. PMID: 39856538.
      View in: PubMed
    13. Aledo-Serrano A, Lewis-Smith D, Leonard H, Bayat A, Junaid M, Hagebeuk E, Fenger CD, Laze J, Rossi A, Trivisano M, Gonzalez-Giraldez B, Lama J, Krey I, Platzer K, Brischoux-Boucher E, Sarret C, Lomax LB, Zanus C, Musante L, Costa P, Moloney P, Delanty N, Russo A, Schönewolf-Greulich B, Bisgaard AM, Berger C, Freri E, Takahashi S, Zacher P, Jung J, Demarest S, Marsh E, Percy A, Neul J, Olson H, Swanson L, Meletti S, Cioclu MC, Ali QZ, Suller A, Beltran-Corbellini A, Gil-Nagel A, Zhang X, Previtali R, Højte AF, Specchio N, Downs J, Lesca G, Rubboli G, Andrade D, Gardella E, Pestana E, Devinsky O, Benke T, Helbig I, Thomas R, Møller RS. The natural history of CDKL5 deficiency disorder into adulthood. medRxiv. 2025 Jan 13. PMID: 39867409.
      View in: PubMed
    14. Downs J, Pichard DC, Kaufmann WE, Horrigan JP, Raspa M, Townend G, Marsh ED, Leonard H, Motil K, Dietz AC, Garg N, Ananth A, Byiers B, Peters S, Beatty C, Symons F, Jacobs A, Youakim J, Suter B, Santosh P, Neul JL, Benke TA. International workshop: what is needed to ensure outcome measures for Rett syndrome are fit-for-purpose for clinical trials? June 7, 2023, Nashville, USA. Trials. 2024 Dec 21; 25(1):845. PMID: 39709426.
      View in: PubMed
    15. Saldaris JM, Demarest S, Jacoby P, Olson HE, Maski K, Pestana-Knight E, Price D, Rajaraman R, Suter B, Weisenberg J, Leonard H, Marsh ED, Benke TA, Downs J. Modification of a parent-report sleep scale for individuals with CDKL5 deficiency disorder: a psychometric study. J Clin Sleep Med. 2024 Dec 01; 20(12):1887-1893. PMID: 38963064.
      View in: PubMed
    16. Camp CR, Banke TG, Xing H, Yu K, Perszyk RE, Epplin MP, Akins NS, Zhang J, Benke TA, Yuan H, Liotta DC, Traynelis SF. Selective Enhancement of the Interneuron Network and Gamma-Band Power via GluN2C/GluN2D NMDA Receptor Potentiation. bioRxiv. 2024 Nov 05. PMID: 39574703.
      View in: PubMed
    17. Ananth A, Fu C, Neul JL, Benke T, Marsh E, Suter B, Ferdinandsen K, Skinner SA, Annese F, Percy AK. MECP2 Variants in Males: More Common than Previously Appreciated. Pediatr Neurol. 2024 Dec; 161:263-267. PMID: 39476560.
      View in: PubMed
    18. Bigelow LJ, Pope EK, Jarvis JHM, Fiset C, Le Maistre-Matthys C, Benke TA, Bernard PB. Early life seizures and olfactory communication in rats. Epilepsia. 2024 Oct; 65(10):3091-3099. PMID: 39221936.
      View in: PubMed
    19. Haviland I, Hector RD, Swanson LC, Verran AS, Sherrill E, Frazier Z, Denny AM, Lucash J, Zhang B, Dubbs HA, Marsh ED, Weisenberg JL, Leonard H, Crippa M, Cogliati F, Russo S, Suter B, Rajaraman R, Percy AK, Schreiber JM, Demarest S, Benke TA, Chopra M, Yu TW, Olson HE. Deletions in the CDKL5 5' untranslated region lead to CDKL5 deficiency disorder. Am J Med Genet A. 2025 Jan; 197(1):e63843. PMID: 39205479.
      View in: PubMed
    20. Saldaris JM, Jacoby P, Downs J, Marsh ED, Leonard H, Pestana-Knight E, Rajaraman R, Weisenberg J, Suter B, Olson HE, Price D, Hong W, Prange E, Benke TA, Demarest S. Psychometric evaluation of clinician- and caregiver-reported clinical severity assessments for individuals with CDKL5 deficiency disorder. Epilepsia. 2024 Oct; 65(10):3064-3075. PMID: 39190322.
      View in: PubMed
    21. Neul JL, Benke TA, Marsh ED, Suter B, Fu C, Ryther RC, Skinner SA, Lieberman DN, Feyma T, Beisang A, Heydemann P, Peters SU, Ananth A, Percy AK. Clinical Features and Disease Progression in Older Individuals with Rett Syndrome. Genes (Basel). 2024 Aug 22; 15(8). PMID: 39202466.
      View in: PubMed
    22. Saldaris JM, Ayalde J, Kankanange S, Keeley J, Leonard H, Jacoby P, Marsh ED, Benke TA, Demarest ST, Downs J. Parent-reported outcome measures evaluating communication in individuals with rare neurodevelopmental disorders: A systematic review. Int J Lang Commun Disord. 2024 Nov-Dec; 59(6):2528-2553. PMID: 39141588.
      View in: PubMed
    23. Percy AK, Neul JL, Benke TA, Berry-Kravis EM, Glaze DG, Marsh ED, Barrett AM, An D, Bishop KM, Youakim JM. Trofinetide for the treatment of Rett syndrome: Long-term safety and efficacy results of the 32-month, open-label LILAC-2 study. Med. 2024 Oct 11; 5(10):1275-1281.e2. PMID: 39025065.
      View in: PubMed
    24. Percy AK, Neul JL, Benke TA, Berry-Kravis EM, Glaze DG, Marsh ED, An D, Bishop KM, Youakim JM. Trofinetide for the treatment of Rett syndrome: Results from the open-label extension LILAC study. Med. 2024 Sep 13; 5(9):1178-1189.e3. PMID: 38917793.
      View in: PubMed
    25. Downs J, Jacoby P, Specchio N, Cross H, Amin S, Bahi-Buisson N, Rajaraman R, Suter B, Devinsky O, Aimetti A, Busse G, Olson HE, Demarest S, Benke TA, Pestana-Knight E. Effects of ganaxolone on non-seizure outcomes in CDKL5 Deficiency Disorder: Double-blind placebo-controlled randomized trial. Eur J Paediatr Neurol. 2024 Jul; 51:140-146. PMID: 38959712.
      View in: PubMed
    26. Simões de Oliveira L, O'Leary HE, Nawaz S, Loureiro R, Davenport EC, Baxter P, Louros SR, Dando O, Perkins E, Peltier J, Trost M, Osterweil EK, Hardingham GE, Cousin MA, Chattarji S, Booker SA, Benke TA, Wyllie DJA, Kind PC. Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder. Mol Autism. 2024 06 14; 15(1):28. PMID: 38877552.
      View in: PubMed
    27. Swanson MA, Jiang H, Busquet N, Carlsen J, Brindley C, Benke TA, Van Hove RA, Friederich MW, MacLean KN, Mesches MH, Van Hove JLK. Deep postnatal phenotyping of a new mouse model of nonketotic hyperglycinemia. J Inherit Metab Dis. 2024 09; 47(5):971-990. PMID: 38840294.
      View in: PubMed
    28. Abbott M, Angione K, Forbes E, Stoecker M, Saenz M, Neul JL, Marsh ED, Skinner SA, Percy AK, Benke TA. Rett syndrome diagnostic odyssey: Limitations of NextGen sequencing. Am J Med Genet A. 2024 Oct; 194(10):e63725. PMID: 38775384.
      View in: PubMed
    29. Saby JN, Mulcahey PJ, Benke TA, Peters SU, Standridge SM, Lieberman DN, Key AP, Percy AK, Nelson CA, Roberts TPL, Neul JL, Marsh ED. Electroencephalographic Correlates of Clinical Severity in the Natural history study of RTT and Related Disorders. Ann Neurol. 2024 Jul; 96(1):175-186. PMID: 38721759.
      View in: PubMed
    30. Swanson MA, Jiang H, Busquet N, Carlsen J, Brindley C, Benke TA, Van Hove RA, Friederich MW, MacLean KN, Mesches MH, Van Hove JLK. Deep postnatal phenotyping of a new mouse model of nonketotic hyperglycinemia. bioRxiv. 2024 Mar 29. PMID: 38586005.
      View in: PubMed
    31. Xu Y, Song R, Perszyk RE, Chen W, Kim S, Park KL, Allen JP, Nocilla KA, Zhang J, XiangWei W, Tankovic A, McDaniels ED, Sheikh R, Mizu RK, Karamchandani MM, Hu C, Kusumoto H, Pecha J, Cappuccio G, Gaitanis J, Sullivan J, Shashi V, Petrovski S, Jauss RT, Lee HK, Bozarth X, Lynch DR, Helbig I, Pierson TM, Boerkoel CF, Myers SJ, Lemke JR, Benke TA, Yuan H, Traynelis SF. De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor. Cell Mol Life Sci. 2024 Mar 28; 81(1):153. PMID: 38538865.
      View in: PubMed
    32. Raspa M, Gwaltney A, Bann C, von Hehn J, Benke TA, Marsh ED, Peters SU, Ananth A, Percy AK, Neul JL. Psychometric Assessment of the Rett Syndrome Caregiver Assessment of Symptom Severity (RCASS). J Autism Dev Disord. 2025 Mar; 55(3):997-1009. PMID: 38438817.
      View in: PubMed
    33. Keeley J, Benson-Goldberg S, Saldaris J, Lariviere J, Leonard H, Marsh ED, Demarest ST, Benke TA, Jacoby P, Downs J. Communication of individuals with CDKL5 deficiency disorder as observed by caregivers: A descriptive qualitative study. Am J Med Genet A. 2024 07; 194(7):e63570. PMID: 38425131.
      View in: PubMed
    34. Saldaris JM, Jacoby P, Marsh ED, Suter B, Leonard H, Olson HE, Rajaraman R, Pestana-Knight E, Weisenberg J, Price D, Drummond C, Benke TA, Demarest S, Downs J. Adapting a measure of gross motor skills for individuals with CDKL5 deficiency disorder: A psychometric study. Epilepsy Res. 2024 Feb; 200:107287. PMID: 38237219.
      View in: PubMed
    35. Neul JL, Percy AK, Benke TA, Berry-Kravis EM, Glaze DG, Peters SU, Marsh ED, An D, Bishop KM, Youakim JM. Trofinetide Treatment Demonstrates a Benefit Over Placebo for the Ability to Communicate in Rett Syndrome. Pediatr Neurol. 2024 Mar; 152:63-72. PMID: 38232652.
      View in: PubMed
    36. Rong M, Benke T, Zulfiqar Ali Q, Aledo-Serrano Á, Bayat A, Rossi A, Devinsky O, Qaiser F, Ali AS, Fasano A, Bassett AS, Andrade DM. Adult Phenotype of SYNGAP1-DEE. Neurol Genet. 2023 Dec; 9(6):e200105. PMID: 38045990.
      View in: PubMed
    37. XiangWei W, Perszyk RE, Liu N, Xu Y, Bhattacharya S, Shaulsky GH, Smith-Hicks C, Fatemi A, Fry AE, Chandler K, Wang T, Vogt J, Cohen JS, Paciorkowski AR, Poduri A, Zhang Y, Wang S, Wang Y, Zhai Q, Fang F, Leng J, Garber K, Myers SJ, Jauss RT, Park KL, Benke TA, Lemke JR, Yuan H, Jiang Y, Traynelis SF. Clinical and functional consequences of GRIA variants in patients with neurological diseases. Cell Mol Life Sci. 2023 Nov 03; 80(11):345. PMID: 37921875.
      View in: PubMed
    38. Neul JL, Benke TA, Marsh ED, Suter B, Silveira L, Fu C, Peters SU, Percy AK. Top caregiver concerns in Rett syndrome and related disorders: data from the US natural history study. J Neurodev Disord. 2023 10 13; 15(1):33. PMID: 37833681.
      View in: PubMed
    39. Fang X, Baggett LM, Caylor RC, Percy AK, Neul JL, Lane JB, Glaze DG, Benke TA, Marsh ED, Motil KJ, Barrish JO, Annese FE, Skinner SA. Parental age effects and Rett syndrome. Am J Med Genet A. 2024 02; 194(2):160-173. PMID: 37768187.
      View in: PubMed
    40. Daniels C, Greene C, Smith L, Pestana-Knight E, Demarest S, Zhang B, Benke TA, Poduri A, Olson HE. CDKL5 deficiency disorder and other infantile-onset genetic epilepsies. Dev Med Child Neurol. 2024 Apr; 66(4):456-468. PMID: 37771170.
      View in: PubMed
    41. Ziniel SI, Mackie A, Saldaris J, Leonard H, Jacoby P, Marsh ED, Suter B, Pestana-Knight E, Olson HE, Price D, Weisenberg J, Rajaraman R, VanderVeen G, Benke TA, Downs J, Demarest S. The development, content and response process validation of a caregiver-reported severity measure for CDKL5 deficiency disorder. Epilepsy Res. 2023 11; 197:107231. PMID: 37751639.
      View in: PubMed
    42. Camp CR, Vlachos A, Klöckner C, Krey I, Banke TG, Shariatzadeh N, Ruggiero SM, Galer P, Park KL, Caccavano A, Kimmel S, Yuan X, Yuan H, Helbig I, Benke TA, Lemke JR, Pelkey KA, McBain CJ, Traynelis SF. Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons. Commun Biol. 2023 09 19; 6(1):952. PMID: 37723282.
      View in: PubMed
    43. Myers SJ, Yuan H, Perszyk RE, Zhang J, Kim S, Nocilla KA, Allen JP, Bain JM, Lemke JR, Lal D, Benke TA, Traynelis SF. Classification of missense variants in the N-methyl-d-aspartate receptor GRIN gene family as gain- or loss-of-function. Hum Mol Genet. 2023 09 16; 32(19):2857-2871. PMID: 37369021.
      View in: PubMed
    44. Neul JL, Benke TA, Marsh ED, Lane JB, Lieberman DN, Skinner SA, Glaze DG, Suter B, Heydemann PT, Beisang AA, Standridge SM, Ryther RCC, Haas RH, Edwards LJ, Ananth A, Percy AK. Distribution of hand function by age in individuals with Rett syndrome. Ann Child Neurol Soc. 2023 Sep; 1(3):228-238. PMID: 38496825.
      View in: PubMed
    45. Percy AK, Neul JL, Benke TA, Marsh ED, Glaze DG. A review of the Rett Syndrome Behaviour Questionnaire and its utilization in the assessment of symptoms associated with Rett syndrome. Front Pediatr. 2023; 11:1229553. PMID: 37635789.
      View in: PubMed
    46. Castano A, Silvestre M, Wells CI, Sanderson JL, Ferrer CA, Ong HW, Lang Y, Richardson W, Silvaroli JA, Bashore FM, Smith JL, Genereux IM, Dempster K, Drewry DH, Pabla NS, Bullock AN, Benke TA, Ultanir SK, Axtman AD. Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology. Elife. 2023 07 25; 12. PMID: 37490324.
      View in: PubMed
    47. Castano A, Silvestre M, Wells CI, Sanderson JL, Ferrer CA, Ong HW, Lang Y, Richardson W, Silvaroli JA, Bashore FM, Smith JL, Genereux IM, Dempster K, Drewry DH, Pabla NS, Bullock AN, Benke TA, Ultanir S, Axtman AD. Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology. bioRxiv. 2023 Jun 16. PMID: 37162893.
      View in: PubMed
    48. Neul JL, Percy AK, Benke TA, Berry-Kravis EM, Glaze DG, Marsh ED, Lin T, Stankovic S, Bishop KM, Youakim JM. Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study. Nat Med. 2023 Jun; 29(6):1468-1475. PMID: 37291210.
      View in: PubMed
    49. Meredith FL, Vu TA, Gehrke B, Benke TA, Dondzillo A, Rennie KJ. Expression of hyperpolarization-activated current (Ih) in zonally defined vestibular calyx terminals of the crista. J Neurophysiol. 2023 06 01; 129(6):1468-1481. PMID: 37198134.
      View in: PubMed
    50. Saldaris J, Leonard H, Wong K, Jacoby P, Spence M, Marsh ED, Benke TA, Demarest S, Downs J. Validating the Communication and Symbolic Behavior Scales-Developmental Profile Infant-Toddler Checklist (CSBS-DP ITC) Beyond Infancy in the CDKL5 Deficiency Disorder. J Autism Dev Disord. 2024 Jul; 54(7):2526-2535. PMID: 37184758.
      View in: PubMed
    51. Olson HE, Demarest S, Pestana-Knight E, Moosa AN, Zhang X, Pérez-Pérez JR, Weisenberg J, O'Connor Prange E, Marsh ED, Rajaraman RR, Suter B, Katyayan A, Haviland I, Daniels C, Zhang B, Greene C, DeLeo M, Swanson L, Love-Nichols J, Benke T, Harini C, Poduri A. Epileptic spasms in CDKL5 deficiency disorder: Delayed treatment and poor response to first-line therapies. Epilepsia. 2023 07; 64(7):1821-1832. PMID: 37114835.
      View in: PubMed
    52. Neul JL, Benke TA, Marsh ED, Suter B, Silveira L, Fu C, Peters SU, Percy AK. Top Caregiver Concerns in Rett syndrome and related disorders: data from the US Natural History Study. Res Sq. 2023 Mar 20. PMID: 36993737.
      View in: PubMed
    53. Saby JN, Peters SU, Benke TA, Standridge SM, Swanson LC, Lieberman DN, Olson HE, Key AP, Percy AK, Neul JL, Nelson CA, Roberts TPL, Marsh ED. Comparison of evoked potentials across four related developmental encephalopathies. J Neurodev Disord. 2023 03 04; 15(1):10. PMID: 36870948.
      View in: PubMed
    54. Wong K, Junaid M, Demarest S, Saldaris J, Benke TA, Marsh ED, Downs J, Leonard H. Correction to: Factors influencing the attainment of major motor milestones in CDKL5 deficiency disorder. Eur J Hum Genet. 2023 Feb; 31(2):252. PMID: 36224270.
      View in: PubMed
    55. Saldaris JM, Jacoby P, Leonard H, Benke TA, Demarest S, Marsh ED, Downs J. Psychometric properties of QI-Disability in CDKL5 Deficiency Disorder: Establishing readiness for clinical trials. Epilepsy Behav. 2023 02; 139:109069. PMID: 36634535.
      View in: PubMed
    56. Stansauk J, Fidell A, Benke T, Schaffer M, Demarest ST. Analysis of electrocardiograms in individuals with CDKL5 deficiency disorder. Am J Med Genet A. 2023 Jan; 191(1):108-111. PMID: 36372969.
      View in: PubMed
    57. Haviland I, Daniels CI, Greene CA, Drew J, Love-Nichols JA, Swanson LC, Smith L, Nie DA, Benke T, Sheidley BR, Zhang B, Poduri A, Olson HE. Genetic Diagnosis Impacts Medical Management for Pediatric Epilepsies. Pediatr Neurol. 2023 01; 138:71-80. PMID: 36403551.
      View in: PubMed
    58. Sanderson JL, Freund RK, Castano AM, Benke TA, Dell'Acqua ML. The CaV1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca2+ channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome. Neuropharmacology. 2022 Dec 01; 220:109271. PMID: 36162529.
      View in: PubMed
    59. Wong K, Junaid M, Demarest S, Saldaris J, Benke TA, Marsh ED, Downs J, Leonard H. Factors influencing the attainment of major motor milestones in CDKL5 deficiency disorder. Eur J Hum Genet. 2023 02; 31(2):169-178. PMID: 35978140.
      View in: PubMed
    60. Leonard H, Whitehouse A, Jacoby P, Benke T, Demarest S, Saldaris J, Wong K, Reddihough D, Williams K, Downs J. Quality of life beyond diagnosis in intellectual disability - Latent profiling. Res Dev Disabil. 2022 Oct; 129:104322. PMID: 35939908.
      View in: PubMed
    61. Saby JN, Mulcahey PJ, Zavez AE, Peters SU, Standridge SM, Swanson LC, Lieberman DN, Olson HE, Key AP, Percy AK, Neul JL, Nelson CA, Roberts TPL, Benke TA, Marsh ED. Electrophysiological biomarkers of brain function in CDKL5 deficiency disorder. Brain Commun. 2022; 4(4):fcac197. PMID: 35974796.
      View in: PubMed
    62. Amin S, Monaghan M, Aledo-Serrano A, Bahi-Buisson N, Chin RF, Clarke AJ, Cross JH, Demarest S, Devinsky O, Downs J, Pestana Knight EM, Olson H, Partridge CA, Stuart G, Trivisano M, Zuberi S, Benke TA. International Consensus Recommendations for the Assessment and Management of Individuals With CDKL5 Deficiency Disorder. Front Neurol. 2022; 13:874695. PMID: 35795799.
      View in: PubMed
    63. Buchanan CB, Stallworth JL, Joy AE, Dixon RE, Scott AE, Beisang AA, Benke TA, Glaze DG, Haas RH, Heydemann PT, Jones MD, Lane JB, Lieberman DN, Marsh ED, Neul JL, Peters SU, Ryther RC, Skinner SA, Standridge SM, Kaufmann WE, Percy AK. Anxiety-like behavior and anxiolytic treatment in the Rett syndrome natural history study. J Neurodev Disord. 2022 05 14; 14(1):31. PMID: 35568815.
      View in: PubMed
    64. Knight EMP, Amin S, Bahi-Buisson N, Benke TA, Cross JH, Demarest ST, Olson HE, Specchio N, Fleming TR, Aimetti AA, Gasior M, Devinsky O. Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial. Lancet Neurol. 2022 05; 21(5):417-427. PMID: 35429480.
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    154. Benke TA, Swann J. The tetanus toxin model of chronic epilepsy. Adv Exp Med Biol. 2004; 548:226-38. PMID: 15250597.
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    155. Trinka E, Walser G, Unterberger I, Luef G, Benke T, Bartha L, Ortler M, Bauer G. Peri-ictal water drinking lateralizes seizure onset to the nondominant temporal lobe. Neurology. 2003 Mar 11; 60(5):873-6. PMID: 12629252.
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    156. Burtscher J, Bartha L, Twerdy K, Eisner W, Benke T. Effect of endoscopic third ventriculostomy on neuropsychological outcome in late onset idiopathic aqueduct stenosis: a prospective study. J Neurol Neurosurg Psychiatry. 2003 Feb; 74(2):222-5. PMID: 12531955.
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    157. Benke TA, Lüthi A, Palmer MJ, Wikström MA, Anderson WW, Isaac JT, Collingridge GL. Mathematical modelling of non-stationary fluctuation analysis for studying channel properties of synaptic AMPA receptors. J Physiol. 2001 Dec 01; 537(Pt 2):407-20. PMID: 11731574.
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    158. Benke T, Butterworth B. Palilalia and repetitive speech: two case studies. Brain Lang. 2001 Jul; 78(1):62-81. PMID: 11412016.
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    159. Trinka E, Unterberger I, Luef G, Benke T, Berger T, Bauer G. Acute aphasia in multiple sclerosis. Arch Neurol. 2001 Jan; 58(1):133-4. PMID: 11176950.
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    160. Benke T, Hohenstein C, Poewe W, Butterworth B. Repetitive speech phenomena in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2000 Sep; 69(3):319-24. PMID: 10945806.
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    161. Voller B, Benke T, Benedetto K, Schnider P, Auff E, Aichner F. Neuropsychological, MRI and EEG findings after very mild traumatic brain injury. Brain Inj. 1999 Oct; 13(10):821-7. PMID: 10576466.
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    162. Lüthi A, Chittajallu R, Duprat F, Palmer MJ, Benke TA, Kidd FL, Henley JM, Isaac JT, Collingridge GL. Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron. 1999 Oct; 24(2):389-99. PMID: 10571232.
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    163. Isaac JT, Lüthi A, Palmer MJ, Anderson WW, Benke TA, Collingridge GL. An investigation of the expression mechanism of LTP of AMPA receptor-mediated synaptic transmission at hippocampal CA1 synapses using failures analysis and dendritic recordings. Neuropharmacology. 1998 Oct-Nov; 37(10-11):1399-410. PMID: 9849675.
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    164. Benke TA, Lüthi A, Isaac JT, Collingridge GL. Modulation of AMPA receptor unitary conductance by synaptic activity. Nature. 1998 Jun 25; 393(6687):793-7. PMID: 9655394.
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    165. Benke T, Hochleitner M, Bauer G. Aura phenomena during syncope. Eur Neurol. 1997; 37(1):28-32. PMID: 9018029.
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    166. Bresink I, Benke TA, Collett VJ, Seal AJ, Parsons CG, Henley JM, Collingridge GL. Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. Br J Pharmacol. 1996 Sep; 119(2):195-204. PMID: 8886398.
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    167. Wilkemeyer MF, Smith KL, Zarei MM, Benke TA, Swann JW, Angelides KJ, Eisensmith RC. Adenovirus-mediated gene transfer into dissociated and explant cultures of rat hippocampal neurons. J Neurosci Res. 1996 Jan 15; 43(2):161-74. PMID: 8820964.
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    168. Benke T, Gasse T, Hittmair-Delazer M, Schmutzhard E. Lyme encephalopathy: long-term neuropsychological deficits years after acute neuroborreliosis. Acta Neurol Scand. 1995 May; 91(5):353-7. PMID: 7639064.
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    169. Berek K, Wagner M, Chemelli AP, Aichner F, Benke T. Hemispheric disconnection in Marchiafava-Bignami disease: clinical, neuropsychological and MRI findings. J Neurol Sci. 1994 May; 123(1-2):2-5. PMID: 8064315.
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    170. Benke TA, Jones OT, Collingridge GL, Angelides KJ. N-Methyl-D-aspartate receptors are clustered and immobilized on dendrites of living cortical neurons. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7819-23. PMID: 7689230.
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    171. Poewe W, Berger W, Benke T, Schelosky L. High-speed memory scanning in Parkinson's disease: adverse effects of levodopa. Ann Neurol. 1991 Jun; 29(6):670-3. PMID: 1892368.
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    172. Schelosky L, Benke T, Poewe WH. Effects of treatment with trihexyphenidyl on cognitive function in early Parkinson's disease. J Neural Transm Suppl. 1991; 33:125-32. PMID: 1753241.
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    173. Kertesz A, Benke T. Sex equality in intrahemispheric language organization. Brain Lang. 1989 Oct; 37(3):401-8. PMID: 2478252.
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    174. Kertesz A, Black SE, Tokar G, Benke T, Carr T, Nicholson L. Periventricular and subcortical hyperintensities on magnetic resonance imaging. 'Rims, caps, and unidentified bright objects'. Arch Neurol. 1988 Apr; 45(4):404-8. PMID: 3355395.
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