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Timothy A. Benke

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-3568

    Collapse Research 
    Collapse research activities and funding
    F32NS009894     (BENKE, TIMOTHY A)Dec 1, 1995
    NIH/NINDS
    PHARMACOLOGICAL DENDRITIC GLUTAMATE CHANGES IN LTP
    Role: Principal Investigator

    K08NS041267     (BENKE, TIMOTHY A)Sep 6, 2001 - Aug 31, 2007
    NIH/NINDS
    Impact of Early-Life Seizures on Synaptic Plasticity
    Role: Principal Investigator

    K02NS056090     (BENKE, TIMOTHY A)May 1, 2007 - Apr 30, 2012
    NIH/NINDS
    Impact of early life seizures on glutamate receptors and synaptic function
    Role: Principal Investigator

    R01NS076577     (BENKE, TIMOTHY A)Sep 1, 2011 - Aug 31, 2016
    NIH/NINDS
    Molecular mechanisms linking early life seizures, autism and intellectual disabil
    Role: Principal Investigator

    U10NS077277     (BENKE, TIMOTHY A)Sep 30, 2011 - Aug 31, 2018
    NIH/NINDS
    Rocky Mountain Network for Neuroscience Clinical Studies (RMNNCS)
    Role: Co-Principal Investigator

    K12NS089417     (BENKE, TIMOTHY A)Jul 1, 2015 - Jun 30, 2020
    NIH/NINDS
    Colorado Neurological Sciences Academic Development Award (NSADA)
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kirk ME, Meredith FL, Benke TA, Rennie KJ. AMPA receptor-mediated rapid EPSCs in vestibular calyx afferents. J Neurophysiol. 2017 Jun 01; 117(6):2312-2323. PMID: 28298303.
      View in: PubMed
    2. Larson A, Weisfeld-Adams JD, Benke TA, Bonnen PE. Cerebrotendinous Xanthomatosis Presenting with Infantile Spasms and Intellectual Disability. JIMD Rep. 2016 Nov 18. PMID: 27858369.
      View in: PubMed
    3. Goodell DJ, Benke TA, Bayer KU. Developmental restoration of LTP deficits in heterozygous CaMKIIa KO mice. J Neurophysiol. 2016 Nov 01; 116(5):2140-2151. PMID: 27535377.
      View in: PubMed
    4. Barcomb K, Hell JW, Benke TA, Bayer KU. The CaMKII/GluN2B Protein Interaction Maintains Synaptic Strength. J Biol Chem. 2016 Jul 29; 291(31):16082-9. PMID: 27246855; PMCID: PMC4965558 [Available on 07/29/17].
    5. Goldman AM, LaFrance WC, Benke T, Asato M, Drane D, Pack A, Syed T, Doss R, Lhatoo S, Fureman B, Dingledine R. 2014 Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across The Lifespan. Epilepsy Curr. 2016 May-Jun; 16(3):198-205. PMID: 27330453; PMCID: PMC4913859.
    6. O'Leary H, Bernard PB, Castano AM, Benke TA. Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure. Neurobiol Dis. 2016 Mar; 87:134-44. PMID: 26706598; PMCID: PMC4742248 [Available on 03/01/17].
    7. Benke TA. GettING in Touch With What Drives Your Inner Funky: Sources of CA1 Gamma Oscillations. Epilepsy Curr. 2015 Sep-Oct; 15(5):271-3. PMID: 26448733; PMCID: PMC4591865.
    8. Stafstrom CE, Benke TA. Autism and Epilepsy: Exploring the Relationship Using Experimental Models. Epilepsy Curr. 2015 Jul-Aug; 15(4):206-10. PMID: 26316869; PMCID: PMC4532234.
    9. Bernard PB, Castano AM, Beitzel CS, Carlson VB, Benke TA. Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype. Epilepsy Behav. 2015 Mar; 44:78-85. PMID: 25659043; PMCID: PMC4405461.
    10. Bernard PB, Benke TA. Early life seizures: evidence for chronic deficits linked to autism and intellectual disability across species and models. Exp Neurol. 2015 Jan; 263:72-8. PMID: 25284323; PMCID: PMC4339032.
    11. Benke TA. What you seize is what you get: do we yet understand epilepsy in rett syndrome? Epilepsy Curr. 2014 Sep; 14(5):283-5. PMID: 25346641; PMCID: PMC4189644.
    12. Barcomb K, Buard I, Coultrap SJ, Kulbe JR, O'Leary H, Benke TA, Bayer KU. Autonomous CaMKII requires further stimulation by Ca2+/calmodulin for enhancing synaptic strength. FASEB J. 2014 Aug; 28(8):3810-9. PMID: 24843070; PMCID: PMC4101658.
    13. Benke T. What the dentate gyrus and the millennial in your basement have in common. Epilepsy Curr. 2014 May; 14(3):152-4. PMID: 24940163; PMCID: PMC4038284.
    14. Bernard PB, Castano AM, Bayer KU, Benke TA. Necessary, but not sufficient: insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures. Neuropharmacology. 2014 Sep; 84:1-12. PMID: 24780380; PMCID: PMC4086946.
    15. Benke T. Benchmark IV Progressing Nicely: Rational Pharmacotherapy May Address Cognitive Decline in Epilepsy. Epilepsy Curr. 2014 Mar; 14(2):90-2. PMID: 24872788; PMCID: PMC4010886.
    16. Bernard PB, Castano AM, O'Leary H, Simpson K, Browning MD, Benke TA. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Neurobiol Dis. 2013 Nov; 59:1-17. PMID: 23831253; PMCID: PMC3775950.
    17. Thyssen A, Mitchell M, Qvarnstrom Y, Rao S, Benke TA, Glodé MP. Eosinophilic meningitis in a previously healthy 13-year-old child. Pediatr Infect Dis J. 2013 Feb; 32(2):194, 198. PMID: 23328824; PMCID: PMC4615707.
    18. Benke T. O brother, wherefore are thou? Calcium-permeable AMPA receptors make an appearance in adult status epilepticus. Epilepsy Curr. 2013 Jan; 13(1):32-4. PMID: 23447737; PMCID: PMC3577084.
    19. Meredith FL, Benke TA, Rennie KJ. Hyperpolarization-activated current (I(h)) in vestibular calyx terminals: characterization and role in shaping postsynaptic events. J Assoc Res Otolaryngol. 2012 Dec; 13(6):745-58. PMID: 22825486; PMCID: PMC3505587.
    20. Boada R, Hutaff-Lee C, Schrader A, Weitzenkamp D, Benke TA, Goldson EJ, Costa AC. Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial. Transl Psychiatry. 2012 Jul 17; 2:e141. PMID: 22806212; PMCID: PMC3410988.
    21. Liu X, Li F, Stubblefield EA, Blanchard B, Richards TL, Larson GA, He Y, Huang Q, Tan AC, Zhang D, Benke TA, Sladek JR, Zahniser NR, Li CY. Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. Cell Res. 2012 Feb; 22(2):321-32. PMID: 22105488; PMCID: PMC3271588.
    22. Wray CD, Benke TA. Effect of price increase of adrenocorticotropic hormone on treatment practices of infantile spasms. Pediatr Neurol. 2010 Sep; 43(3):163-6. PMID: 20691936; PMCID: PMC3197710.
    23. Stubblefield EA, Benke TA. Distinct AMPA-type glutamatergic synapses in developing rat CA1 hippocampus. J Neurophysiol. 2010 Oct; 104(4):1899-912. PMID: 20685930; PMCID: PMC2957466.
    24. van der Knaap MS, Lai V, Köhler W, Salih MA, Fonseca MJ, Benke TA, Wilson C, Jayakar P, Aine MR, Dom L, Lynch B, Kálmánchey R, Pietsch P, Errami A, Scheper GC. Megalencephalic leukoencephalopathy with cysts without MLC1 defect. Ann Neurol. 2010 Jun; 67(6):834-7. PMID: 20517947.
      View in: PubMed
    25. Bernard TJ, Fenton LZ, Apkon SD, Boada R, Wilkening GN, Wilkinson CC, Soep JB, Miyamoto SD, Tripputi M, Armstrong-Wells J, Benke TA, Manco-Johnson MJ, Goldenberg NA. Biomarkers of hypercoagulability and inflammation in childhood-onset arterial ischemic stroke. J Pediatr. 2010 Apr; 156(4):651-6. PMID: 20022340.
      View in: PubMed
    26. Robertson HR, Gibson ES, Benke TA, Dell'Acqua ML. Regulation of postsynaptic structure and function by an A-kinase anchoring protein-membrane-associated guanylate kinase scaffolding complex. J Neurosci. 2009 Jun 17; 29(24):7929-43. PMID: 19535604; PMCID: PMC2716089.
    27. Oskarsson B, Zawadzki L, Benke T, Quan D. Neuromuscular hyperexcitability associated with acetylcholine receptor antibodies in a child. J Child Neurol. 2009 Jan; 24(1):90-2. PMID: 18936193.
      View in: PubMed
    28. Cornejo BJ, Mesches MH, Benke TA. A single early-life seizure impairs short-term memory but does not alter spatial learning, recognition memory, or anxiety. Epilepsy Behav. 2008 Nov; 13(4):585-92. PMID: 18678283; PMCID: PMC2586615.
    29. Haag A, Knake S, Hamer HM, Boesebeck F, Freitag H, Schulz R, Baum P, Helmstaedter C, Wellmer J, Urbach H, Hopp P, Mayer T, Hufnagel A, Jokeit H, Lerche H, Uttner I, Meencke HJ, Meierkord H, Pauli E, Runge U, Saar J, Trinka E, Benke T, Vulliemoz S, Wiegand G, Stephani U, Wieser HG, Rating D, Werhahn K, Noachtar S, Schulze-Bonhage A, Wagner K, Alpherts WC, Boas Wv, Rosenow F. The Wada test in Austrian, Dutch, German, and Swiss epilepsy centers from 2000 to 2005: a review of 1421 procedures. Epilepsy Behav. 2008 Jul; 13(1):83-9. PMID: 18358786.
      View in: PubMed
    30. Stafstrom CE, Benke TA. Early-life seizures and cognitive impairment: a spiny problem? Epilepsy Curr. 2008 Jan-Feb; 8(1):27-8. PMID: 18265887; PMCID: PMC2238652.
    31. Bernard TJ, deVeber GA, Benke TA. Athletic participation after acute ischemic childhood stroke: a survey of pediatric stroke experts. J Child Neurol. 2007 Aug; 22(8):1050-3. PMID: 17761660.
      View in: PubMed
    32. Cornejo BJ, Mesches MH, Coultrap S, Browning MD, Benke TA. A single episode of neonatal seizures permanently alters glutamatergic synapses. Ann Neurol. 2007 May; 61(5):411-26. PMID: 17323345.
      View in: PubMed
    33. Hall DA, Parsons J, Benke T. Paroxysmal nonkinesigenic dystonia and celiac disease. Mov Disord. 2007 Apr 15; 22(5):708-10. PMID: 17377923.
      View in: PubMed
    34. Jones J, Stubblefield EA, Benke TA, Staley KJ. Desynchronization of glutamate release prolongs synchronous CA3 network activity. J Neurophysiol. 2007 May; 97(5):3812-8. PMID: 17344368.
      View in: PubMed
    35. Dzhala VI, Talos DM, Sdrulla DA, Brumback AC, Mathews GC, Benke TA, Delpire E, Jensen FE, Staley KJ. NKCC1 transporter facilitates seizures in the developing brain. Nat Med. 2005 Nov; 11(11):1205-13. PMID: 16227993.
      View in: PubMed
    36. Schnee ME, Lawton DM, Furness DN, Benke TA, Ricci AJ. Auditory hair cell-afferent fiber synapses are specialized to operate at their best frequencies. Neuron. 2005 Jul 21; 47(2):243-54. PMID: 16039566.
      View in: PubMed
    37. Bannister NJ, Benke TA, Mellor J, Scott H, Gürdal E, Crabtree JW, Isaac JT. Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortex. J Neurosci. 2005 May 25; 25(21):5259-71. PMID: 15917466.
      View in: PubMed
    38. Benke T, Chemelli A, Lottersberger C, Waldenberger P, Karner E, Trinka E. Transient global amnesia triggered by the intracarotid amobarbital procedure. Epilepsy Behav. 2005 Mar; 6(2):274-8. PMID: 15710318.
      View in: PubMed
    39. Rennie KJ, Streeter MA, Benke TA, Moritz AT. Modeling channel properties in vestibular calyx terminals. Biomed Sci Instrum. 2005; 41:358-63. PMID: 15850132.
      View in: PubMed
    40. Lüthi A, Wikström MA, Palmer MJ, Matthews P, Benke TA, Isaac JT, Collingridge GL. Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity. BMC Neurosci. 2004 Nov 11; 5:44. PMID: 15538948; PMCID: PMC535344.
    41. Lyle P, Benke T, Forno E, Branum J, Parker S. Evaluation of encephalitis in the toddler: what part of negative don't you understand? Curr Opin Pediatr. 2004 Oct; 16(5):567-70. PMID: 15367852.
      View in: PubMed
    42. Benke TA, Swann J. The tetanus toxin model of chronic epilepsy. Adv Exp Med Biol. 2004; 548:226-38. PMID: 15250597.
      View in: PubMed
    43. Trinka E, Walser G, Unterberger I, Luef G, Benke T, Bartha L, Ortler M, Bauer G. Peri-ictal water drinking lateralizes seizure onset to the nondominant temporal lobe. Neurology. 2003 Mar 11; 60(5):873-6. PMID: 12629252.
      View in: PubMed
    44. Benke TA, Lüthi A, Palmer MJ, Wikström MA, Anderson WW, Isaac JT, Collingridge GL. Mathematical modelling of non-stationary fluctuation analysis for studying channel properties of synaptic AMPA receptors. J Physiol. 2001 Dec 01; 537(Pt 2):407-20. PMID: 11731574; PMCID: PMC2278972.
    45. Trinka E, Unterberger I, Luef G, Benke T, Berger T, Bauer G. Acute aphasia in multiple sclerosis. Arch Neurol. 2001 Jan; 58(1):133-4. PMID: 11176950.
      View in: PubMed
    46. Lüthi A, Chittajallu R, Duprat F, Palmer MJ, Benke TA, Kidd FL, Henley JM, Isaac JT, Collingridge GL. Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron. 1999 Oct; 24(2):389-99. PMID: 10571232.
      View in: PubMed
    47. Isaac JT, Lüthi A, Palmer MJ, Anderson WW, Benke TA, Collingridge GL. An investigation of the expression mechanism of LTP of AMPA receptor-mediated synaptic transmission at hippocampal CA1 synapses using failures analysis and dendritic recordings. Neuropharmacology. 1998 Oct-Nov; 37(10-11):1399-410. PMID: 9849675.
      View in: PubMed
    48. Benke TA, Lüthi A, Isaac JT, Collingridge GL. Modulation of AMPA receptor unitary conductance by synaptic activity. Nature. 1998 Jun 25; 393(6687):793-7. PMID: 9655394.
      View in: PubMed
    49. Bresink I, Benke TA, Collett VJ, Seal AJ, Parsons CG, Henley JM, Collingridge GL. Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. Br J Pharmacol. 1996 Sep; 119(2):195-204. PMID: 8886398; PMCID: PMC1915856.
    50. Wilkemeyer MF, Smith KL, Zarei MM, Benke TA, Swann JW, Angelides KJ, Eisensmith RC. Adenovirus-mediated gene transfer into dissociated and explant cultures of rat hippocampal neurons. J Neurosci Res. 1996 Jan 15; 43(2):161-74. PMID: 8820964.
      View in: PubMed
    51. Benke TA, Jones OT, Collingridge GL, Angelides KJ. N-Methyl-D-aspartate receptors are clustered and immobilized on dendrites of living cortical neurons. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7819-23. PMID: 7689230; PMCID: PMC47234.
    52. Poewe W, Berger W, Benke T, Schelosky L. High-speed memory scanning in Parkinson's disease: adverse effects of levodopa. Ann Neurol. 1991 Jun; 29(6):670-3. PMID: 1892368.
      View in: PubMed
    53. Kertesz A, Benke T. Sex equality in intrahemispheric language organization. Brain Lang. 1989 Oct; 37(3):401-8. PMID: 2478252.
      View in: PubMed
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