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Linda Faye van Dyk

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology

    Collapse Research 
    Collapse research activities and funding
    R01CA103632     (VAN DYK, LINDA F)Apr 15, 2004 - Feb 28, 2010
    In Vivo Analysis of Viral Cyclin
    Role: Principal Investigator

    R03AI082490     (VAN DYK, LINDA F)May 8, 2009 - Apr 30, 2011
    Characterization of an animal model of chronic infection and disease
    Role: Principal Investigator

    R01CA168558     (VAN DYK, LINDA F)Jul 1, 2012 - Jun 30, 2017
    Cyclin requirements in gammaherpesvirus infection and disease
    Role: Principal Investigator

    R56AI091994     (VAN DYK, LINDA F)Sep 15, 2012 - Aug 31, 2014
    Regulation of Herpesvirus Infection by Viral miRNAs
    Role: Principal Investigator

    R01AI106287     (CHU, HONG W)Dec 1, 2013 - Nov 30, 2018
    IRAK-M in lung defense against rhinovirus infection
    Role: Co-Principal Investigator

    R01AI121300     (VAN DYK, LINDA F)Apr 19, 2016 - Mar 31, 2020
    Non-coding RNAs in Gammaherpesvirus Infection and Disease
    Role: Principal Investigator

    R21AI134084     (VAN DYK, LINDA F)Jul 14, 2017 - Jun 30, 2019
    Single cell analysis of virus and host gene expression in gammaherpesvirus infection
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Niemeyer BF, Oko LM, Medina EM, Oldenburg DG, White DW, Cool CD, Clambey ET, van Dyk LF. Host Tumor Suppressor p18INK4c functions as a potent cell-intrinsic inhibitor of ?HV68 reactivation and pathogenesis. J Virol. 2018 Jan 03. PMID: 29298882.
      View in: PubMed
    2. Kimball AK, Oko LM, Bullock BL, Nemenoff RA, van Dyk LF, Clambey ET. A Beginner's Guide to Analyzing and Visualizing Mass Cytometry Data. J Immunol. 2018 01 01; 200(1):3-22. PMID: 29255085.
      View in: PubMed
    3. Getahun A, Wemlinger SM, Rudra P, Santiago ML, van Dyk LF, Cambier JC. Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway. J Exp Med. 2017 Apr 03; 214(4):931-941. PMID: 28341640.
      View in: PubMed
    4. Feldman ER, Kara M, Oko LM, Grau KR, Krueger BJ, Zhang J, Feng P, van Dyk LF, Renne R, Tibbetts SA. A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency. mSphere. 2016 Apr; 1(2). PMID: 27110595.
      View in: PubMed
    5. Zhou X, Loomis-King H, Gurczynski SJ, Wilke CA, Konopka KE, Ptaschinski C, Coomes SM, Iwakura Y, van Dyk LF, Lukacs NW, Moore BB. Bone marrow transplantation alters lung antigen-presenting cells to promote TH17 response and the development of pneumonitis and fibrosis following gammaherpesvirus infection. Mucosal Immunol. 2016 05; 9(3):610-20. PMID: 26376362; PMCID: PMC4794430.
    6. Williams LM, Niemeyer BF, Franklin DS, Clambey ET, van Dyk LF. A Conserved Gammaherpesvirus Cyclin Specifically Bypasses Host p18(INK4c) To Promote Reactivation from Latency. J Virol. 2015 Nov; 89(21):10821-31. PMID: 26292318; PMCID: PMC4621100.
    7. Wu Q, Jiang D, Huang C, van Dyk LF, Li L, Chu HW. Trehalose-mediated autophagy impairs the anti-viral function of human primary airway epithelial cells. PLoS One. 2015; 10(4):e0124524. PMID: 25879848; PMCID: PMC4400043.
    8. Diebel KW, Oko LM, Medina EM, Niemeyer BF, Warren CJ, Claypool DJ, Tibbetts SA, Cool CD, Clambey ET, van Dyk LF. Gammaherpesvirus small noncoding RNAs are bifunctional elements that regulate infection and contribute to virulence in vivo. MBio. 2015 Feb 17; 6(1):e01670-14. PMID: 25691585; PMCID: PMC4337559.
    9. Freeman ML, Burkum CE, Cookenham T, Roberts AD, Lanzer KG, Huston GE, Jensen MK, Sidney J, Peters B, Kohlmeier JE, Woodland DL, van Dyk LF, Sette A, Blackman MA. CD4 T cells specific for a latency-associated ?-herpesvirus epitope are polyfunctional and cytotoxic. J Immunol. 2014 Dec 15; 193(12):5827-34. PMID: 25378595; PMCID: PMC4301266.
    10. Ashley SL, Jegal Y, Moore TA, van Dyk LF, Laouar Y, Moore BB. ?-Herpes virus-68, but not Pseudomonas aeruginosa or influenza A (H1N1), exacerbates established murine lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2014 Aug 01; 307(3):L219-30. PMID: 24879051; PMCID: PMC4121641.
    11. Feldman ER, Kara M, Coleman CB, Grau KR, Oko LM, Krueger BJ, Renne R, van Dyk LF, Tibbetts SA. Virus-encoded microRNAs facilitate gammaherpesvirus latency and pathogenesis in vivo. MBio. 2014 May 27; 5(3):e00981-14. PMID: 24865551; PMCID: PMC4045068.
    12. Diebel KW, Claypool DJ, van Dyk LF. A conserved RNA polymerase III promoter required for gammaherpesvirus TMER transcription and microRNA processing. Gene. 2014 Jul 01; 544(1):8-18. PMID: 24747015; PMCID: PMC4544698.
    13. Wu Q, van Dyk LF, Jiang D, Dakhama A, Li L, White SR, Gross A, Chu HW. Interleukin-1 receptor-associated kinase M (IRAK-M) promotes human rhinovirus infection in lung epithelial cells via the autophagic pathway. Virology. 2013 Nov; 446(1-2):199-206. PMID: 24074582; PMCID: PMC3804030.
    14. Rubtsova K, Rubtsov AV, van Dyk LF, Kappler JW, Marrack P. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):E3216-24. PMID: 23922396; PMCID: PMC3752276.
    15. Getahun A, Smith MJ, Kogut I, van Dyk LF, Cambier JC. Retention of anergy and inhibition of antibody responses during acute ? herpesvirus 68 infection. J Immunol. 2012 Sep 15; 189(6):2965-74. PMID: 22904300; PMCID: PMC3436999.
    16. Larson JD, Thurman JM, Rubtsov AV, Claypool D, Marrack P, van Dyk LF, Torres RM, Pelanda R. Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):E1092-100. PMID: 22474381; PMCID: PMC3345002.
    17. Lee KS, Suarez AL, Claypool DJ, Armstrong TK, Buckingham EM, van Dyk LF. Viral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclins. PLoS Pathog. 2012 Feb; 8(2):e1002496. PMID: 22319441; PMCID: PMC3271081.
    18. Suárez AL, Kong R, George T, He L, Yue Z, van Dyk LF. Gammaherpesvirus 68 infection of endothelial cells requires both host autophagy genes and viral oncogenes for optimal survival and persistence. J Virol. 2011 Jul; 85(13):6293-308. PMID: 21490089; PMCID: PMC3126501.
    19. Orioli A, Pascali C, Quartararo J, Diebel KW, Praz V, Romascano D, Percudani R, van Dyk LF, Hernandez N, Teichmann M, Dieci G. Widespread occurrence of non-canonical transcription termination by human RNA polymerase III. Nucleic Acids Res. 2011 Jul; 39(13):5499-512. PMID: 21421562; PMCID: PMC3141230.
    20. Vannella KM, Luckhardt TR, Wilke CA, van Dyk LF, Toews GB, Moore BB. Latent herpesvirus infection augments experimental pulmonary fibrosis. Am J Respir Crit Care Med. 2010 Mar 01; 181(5):465-77. PMID: 20185751; PMCID: PMC2830399.
    21. Diebel KW, Smith AL, van Dyk LF. Mature and functional viral miRNAs transcribed from novel RNA polymerase III promoters. RNA. 2010 Jan; 16(1):170-85. PMID: 19948768; PMCID: PMC2802027.
    22. Lee KS, Cool CD, van Dyk LF. Murine gammaherpesvirus 68 infection of gamma interferon-deficient mice on a BALB/c background results in acute lethal pneumonia that is dependent on specific viral genes. J Virol. 2009 Nov; 83(21):11397-401. PMID: 19710134; PMCID: PMC2772809.
    23. Lee KS, Groshong SD, Cool CD, Kleinschmidt-DeMasters BK, van Dyk LF. Murine gammaherpesvirus 68 infection of IFNgamma unresponsive mice: a small animal model for gammaherpesvirus-associated B-cell lymphoproliferative disease. Cancer Res. 2009 Jul 01; 69(13):5481-9. PMID: 19531651; PMCID: PMC2712112.
    24. Suárez AL, van Dyk LF. Endothelial cells support persistent gammaherpesvirus 68 infection. PLoS Pathog. 2008 Sep 12; 4(9):e1000152. PMID: 18787698; PMCID: PMC2526176.
    25. McMillan TR, Moore BB, Weinberg JB, Vannella KM, Fields WB, Christensen PJ, van Dyk LF, Toews GB. Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus. Am J Respir Crit Care Med. 2008 Apr 01; 177(7):771-80. PMID: 18187693; PMCID: PMC2277211.
    26. Loh J, Huang Q, Petros AM, Nettesheim D, van Dyk LF, Labrada L, Speck SH, Levine B, Olejniczak ET, Virgin HW. A surface groove essential for viral Bcl-2 function during chronic infection in vivo. PLoS Pathog. 2005 Sep; 1(1):e10. PMID: 16201011; PMCID: PMC1238745.
    27. Upton JW, van Dyk LF, Speck SH. Characterization of murine gammaherpesvirus 68 v-cyclin interactions with cellular cdks. Virology. 2005 Oct 25; 341(2):271-83. PMID: 16102793.
      View in: PubMed
    28. Clambey ET, van Dyk LF, Kappler JW, Marrack P. Non-malignant clonal expansions of CD8+ memory T cells in aged individuals. Immunol Rev. 2005 Jun; 205:170-89. PMID: 15882353.
      View in: PubMed
    29. Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Grässer FA, van Dyk LF, Ho CK, Shuman S, Chien M, Russo JJ, Ju J, Randall G, Lindenbach BD, Rice CM, Simon V, Ho DD, Zavolan M, Tuschl T. Identification of microRNAs of the herpesvirus family. Nat Methods. 2005 Apr; 2(4):269-76. PMID: 15782219.
      View in: PubMed
    30. van Dyk LF, Virgin HW, Speck SH. Maintenance of gammaherpesvirus latency requires viral cyclin in the absence of B lymphocytes. J Virol. 2003 May; 77(9):5118-26. PMID: 12692214; PMCID: PMC153990.
    31. Tibbetts SA, van Dyk LF, Speck SH, Virgin HW. Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus. J Virol. 2002 Jul; 76(14):7125-32. PMID: 12072512; PMCID: PMC136321.
    32. Gangappa S, van Dyk LF, Jewett TJ, Speck SH, Virgin HW. Identification of the in vivo role of a viral bcl-2. J Exp Med. 2002 Apr 01; 195(7):931-40. PMID: 11927636; PMCID: PMC2193719.
    33. van Dyk LF, Virgin HW, Speck SH. The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency. J Virol. 2000 Aug; 74(16):7451-61. PMID: 10906198; PMCID: PMC112265.
    34. van Dyk LF, Hess JL, Katz JD, Jacoby M, Speck SH, Virgin HW IV. The murine gammaherpesvirus 68 v-cyclin gene is an oncogene that promotes cell cycle progression in primary lymphocytes. J Virol. 1999 Jun; 73(6):5110-22. PMID: 10233974; PMCID: PMC112556.
    35. Lissy NA, Van Dyk LF, Becker-Hapak M, Vocero-Akbani A, Mendler JH, Dowdy SF. TCR antigen-induced cell death occurs from a late G1 phase cell cycle check point. Immunity. 1998 Jan; 8(1):57-65. PMID: 9462511.
      View in: PubMed
    36. Fabry Z, Waldschmidt MM, Van Dyk L, Moore SA, Hart MN. Activation of CD4+ lymphocytes by syngeneic brain microvascular smooth muscle cells. J Immunol. 1990 Aug 15; 145(4):1099-104. PMID: 1974273.
      View in: PubMed
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