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Marcelo Carlos Sousa

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentChemistry & Biochemistry
Phone303/735-4341
ORCID ORCID Icon0000-0002-0242-3619 Additional info

    Collapse Research 
    Collapse research activities and funding
    R01AI060841     (SOUSA, MARCELO CARLOS)Jul 1, 2004 - Jun 30, 2009
    NIH/NIAID
    Mechanism of Enzymes Mediating Resistance in Pseudomonas
    Role: Principal Investigator

    R56AI060841     (SOUSA, MARCELO C.)Jul 1, 2004 - Jun 30, 2012
    NIH/NIAID
    Mechanisms of Resistance in Gram-Negative Bacteria
    Role: Principal Investigator

    R01EY019050     (SOUSA, MARCELO C.)May 1, 2009 - Apr 30, 2013
    NIH/NEI
    Molecular Mechanism of Retinal Guanylate Cyclase Activation by GCAPs
    Role: Principal Investigator

    R01AI080709     (SOUSA, MARCELO C.)May 22, 2009 - Jan 31, 2017
    NIH/NIAID
    Transport and Insertion of Outer Membrane Proteins
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Warner LR, Gatzeva-Topalova PZ, Doerner PA, Pardi A, Sousa MC. Flexibility in the Periplasmic Domain of BamA Is Important for Function. Structure. 2017 Jan 03; 25(1):94-106. PMID: 27989620.
      View in: PubMed
    2. Fleming PJ, Patel DS, Wu EL, Qi Y, Yeom MS, Sousa MC, Fleming KG, Im W. BamA POTRA Domain Interacts with a Native Lipid Membrane Surface. Biophys J. 2016 Jun 21; 110(12):2698-709. PMID: 27332128.
      View in: PubMed
    3. Bergal HT, Hopkins AH, Metzner SI, Sousa MC. The Structure of a BamA-BamD Fusion Illuminates the Architecture of the ß-Barrel Assembly Machine Core. Structure. 2016 Feb 02; 24(2):243-51. PMID: 26749448.
      View in: PubMed
    4. Nordwald EM, Plaks JG, Snell JR, Sousa MC, Kaar JL. Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Enzyme Structure. Chembiochem. 2015 Nov; 16(17):2456-9. PMID: 26388426.
      View in: PubMed
    5. Edwards DT, Faulk JK, Sanders AW, Bull MS, Walder R, LeBlanc MA, Sousa MC, Perkins TT. Optimizing 1-µs-Resolution Single-Molecule Force Spectroscopy on a Commercial Atomic Force Microscope. Nano Lett. 2015 Oct 14; 15(10):7091-8. PMID: 26421945.
      View in: PubMed
    6. Doerner PA, Sousa MC. Small Angle X-ray Scattering (SAXS) Characterization of the POTRA Domains of BamA. Methods Mol Biol. 2015; 1329:149-55. PMID: 26427682.
      View in: PubMed
    7. Jansen KB, Baker SL, Sousa MC. Crystal structure of BamB bound to a periplasmic domain fragment of BamA, the central component of the ß-barrel assembly machine. J Biol Chem. 2015 Jan 23; 290(4):2126-36. PMID: 25468906.
      View in: PubMed
    8. Turco MM, Sousa MC. The structure and specificity of the type III secretion system effector NleC suggest a DNA mimicry mechanism of substrate recognition. Biochemistry. 2014 Aug 12; 53(31):5131-9. PMID: 25040221.
      View in: PubMed
    9. Lee M, Sousa MC. Structural basis for substrate specificity in ArnB. A key enzyme in the polymyxin resistance pathway of Gram-negative bacteria. Biochemistry. 2014 Feb 04; 53(4):796-805. PMID: 24460375.
      View in: PubMed
    10. Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC. Structure of mediator of RhoA-dependent invasion (MRDI) explains its dual function as a metabolic enzyme and a mediator of cell invasion. Biochemistry. 2013 Aug 20; 52(33):5675-84. PMID: 23859498.
      View in: PubMed
    11. Jansen KB, Baker SL, Sousa MC. Crystal structure of BamB from Pseudomonas aeruginosa and functional evaluation of its conserved structural features. PLoS One. 2012; 7(11):e49749. PMID: 23189157.
      View in: PubMed
    12. Warner LR, Varga K, Lange OF, Baker SL, Baker D, Sousa MC, Pardi A. Structure of the BamC two-domain protein obtained by Rosetta with a limited NMR data set. J Mol Biol. 2011 Aug 05; 411(1):83-95. PMID: 21624375.
      View in: PubMed
    13. Sandoval CM, Baker SL, Jansen K, Metzner SI, Sousa MC. Crystal structure of BamD: an essential component of the ß-Barrel assembly machinery of gram-negative bacteria. J Mol Biol. 2011 Jun 10; 409(3):348-57. PMID: 21463635.
      View in: PubMed
    14. Gatzeva-Topalova PZ, Warner LR, Pardi A, Sousa MC. Structure and flexibility of the complete periplasmic domain of BamA: the protein insertion machine of the outer membrane. Structure. 2010 Nov 10; 18(11):1492-501. PMID: 21070948.
      View in: PubMed
    15. Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, Palczewski K. Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure. 2010 Jan 13; 18(1):116-26. PMID: 20152158.
      View in: PubMed
    16. Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. Mol Cell Proteomics. 2009 Oct; 8(10):2308-20. PMID: 19620624.
      View in: PubMed
    17. Walton TA, Sandoval CM, Fowler CA, Pardi A, Sousa MC. The cavity-chaperone Skp protects its substrate from aggregation but allows independent folding of substrate domains. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1772-7. PMID: 19181847.
      View in: PubMed
    18. Gatzeva-Topalova PZ, Walton TA, Sousa MC. Crystal structure of YaeT: conformational flexibility and substrate recognition. Structure. 2008 Dec 10; 16(12):1873-81. PMID: 19081063.
      View in: PubMed
    19. Stephen R, Filipek S, Palczewski K, Sousa MC. Ca2+ -dependent regulation of phototransduction. Photochem Photobiol. 2008 Jul-Aug; 84(4):903-10. PMID: 18346093.
      View in: PubMed
    20. Kline T, Trent MS, Stead CM, Lee MS, Sousa MC, Felise HB, Nguyen HV, Miller SI. Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance. Bioorg Med Chem Lett. 2008 Feb 15; 18(4):1507-10. PMID: 18187325.
      View in: PubMed
    21. Stephen R, Bereta G, Golczak M, Palczewski K, Sousa MC. Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1. Structure. 2007 Nov; 15(11):1392-402. PMID: 17997965.
      View in: PubMed
    22. Stephen R, Palczewski K, Sousa MC. The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. J Mol Biol. 2006 Jun 02; 359(2):266-75. PMID: 16626734.
      View in: PubMed
    23. Gatzeva-Topalova PZ, May AP, Sousa MC. Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance. Structure. 2005 Jun; 13(6):929-42. PMID: 15939024.
      View in: PubMed
    24. Gatzeva-Topalova PZ, May AP, Sousa MC. Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. Biochemistry. 2005 Apr 12; 44(14):5328-38. PMID: 15807526.
      View in: PubMed
    25. Gatzeva-Topalova PZ, May AP, Sousa MC. Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. Biochemistry. 2004 Oct 26; 43(42):13370-9. PMID: 15491143.
      View in: PubMed
    26. Walton TA, Sousa MC. Crystal structure of Skp, a prefoldin-like chaperone that protects soluble and membrane proteins from aggregation. Mol Cell. 2004 Aug 13; 15(3):367-74. PMID: 15304217.
      View in: PubMed
    27. Ridge KD, Abdulaev NG, Sousa M, Palczewski K. Phototransduction: crystal clear. Trends Biochem Sci. 2003 Sep; 28(9):479-87. PMID: 13678959.
      View in: PubMed
    28. Sousa MC, Kessler BM, Overkleeft HS, McKay DB. Crystal structure of HslUV complexed with a vinyl sulfone inhibitor: corroboration of a proposed mechanism of allosteric activation of HslV by HslU. J Mol Biol. 2002 May 03; 318(3):779-85. PMID: 12054822.
      View in: PubMed
    29. Sousa MC, McKay DB. Structure of the universal stress protein of Haemophilus influenzae. Structure. 2001 Dec; 9(12):1135-41. PMID: 11738040.
      View in: PubMed
    30. Sousa MC, McKay DB. The hydroxyl of threonine 13 of the bovine 70-kDa heat shock cognate protein is essential for transducing the ATP-induced conformational change. Biochemistry. 1998 Nov 03; 37(44):15392-9. PMID: 9799500.
      View in: PubMed
    31. Metzner SI, Sousa MC, Hellman U, Cazzulo JJ, Parodi AJ. The use of UDP-Glc:glycoprotein glucosyltransferase for radiolabeling protein-linked high mannose-type oligosaccharides. Cell Mol Biol (Noisy-le-grand). 1996 Jul; 42(5):631-5. PMID: 8832092.
      View in: PubMed
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