Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Natalie Ahn

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentChemistry & Biochemistry
Phone303/492-4799

    Collapse Research 
    Collapse research activities and funding
    F32AM007590     (AHN, NATALIE G)Dec 1, 1985
    NIH/NIADDK
    KINETICS OF INSULIN BINDING TO RAT EPIDIDYMAL FAT CELLS
    Role: Principal Investigator

    F32DK007590     (AHN, NATALIE G)Jul 24, 1986
    NIH/NIDDK
    KINETICS OF INSULIN BINDING TO RAT EPIDIDYMAL FAT CELLS
    Role: Principal Investigator

    R01GM048521     (AHN, NATALIE G.)Sep 30, 1992 - Nov 30, 2006
    NIH/NIGMS
    Biochemical Analysis of MKK/ERK Pathway
    Role: Principal Investigator

    R01CA079801     (AHN, NATALIE G)Jan 1, 1999 - Dec 31, 2003
    NIH/NCI
    MAP KINASE SIGNALING IN HEMATOPOIETIC DIFFERENTIATION
    Role: Principal Investigator

    T32GM008759     (AHN, NATALIE G)Jul 1, 2000 - Jun 30, 2021
    NIH/NIGMS
    Predoctoral Training in Signaling and Cellular Regulation
    Role: Principal Investigator

    R13CA094350     (AHN, NATALIE G)Mar 1, 2002 - Feb 28, 2003
    NIH/NCI
    Protein Phosphorylation and Cellular Regulation
    Role: Principal Investigator

    S10RR021005     (AHN, NATALIE G.)Apr 15, 2005 - Apr 14, 2006
    NIH/NCRR
    AB-4000 QTRAP MASS SPECTROMETER
    Role: Principal Investigator

    R13DK075259     (DOHLMAN, HENRIK G.)Apr 1, 2006 - Mar 31, 2009
    NIH/NIDDK
    Gordon Conference on "Phosphorylation and G Protein Signaling Networks"
    Role: Co-Principal Investigator

    R01GM074134     (AHN, NATALIE G.)Jan 1, 2007 - Dec 31, 2011
    NIH/NIGMS
    Regulation of Map Kinase by Protein Motions
    Role: Principal Investigator

    R01CA118972     (AHN, NATALIE G.)May 1, 2007 - Mar 31, 2013
    NIH/NCI
    Signal Transduction Pathways in Melanoma
    Role: Principal Investigator

    R13HL102994     (AHN, NATALIE G.)Mar 5, 2010 - Mar 4, 2011
    NIH/NHLBI
    2010 US-HUPO Conference -- Proteomics from Bench to Clinic
    Role: Principal Investigator

    S10RR026641     (AHN, NATALIE G.)Aug 1, 2010 - Jul 31, 2011
    NIH/NCRR
    ABI Elite ESI-QqTOF Mass Spectrometry System
    Role: Principal Investigator

    R01GM105997     (AHN, NATALIE G)Jul 1, 2013 - Apr 30, 2017
    NIH/NIGMS
    Technologies to Define and Map Novel Interorganelle Macromolecular Interactions
    Role: Principal Investigator

    R01GM114594     (AHN, NATALIE G)Dec 1, 2015 - Nov 30, 2019
    NIH/NIGMS
    Linking Dynamics to Catalysis and Inhibition in ERK2
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mattiroli F, Bhattacharyya S, Dyer PN, White AE, Sandman K, Burkhart BW, Byrne KR, Lee T, Ahn NG, Santangelo TJ, Reeve JN, Luger K. Structure of histone-based chromatin in Archaea. Science. 2017 Aug 11; 357(6351):609-612. PMID: 28798133.
      View in: PubMed
    2. Connacher MK, Tay JW, Ahn NG. Rear-polarized Wnt5a-receptor-actin-myosin-polarity (WRAMP) structures promote the speed and persistence of directional cell migration. Mol Biol Cell. 2017 Jul 07; 28(14):1924-1936. PMID: 28592632.
      View in: PubMed
    3. Mattiroli F, Gu Y, Yadav T, Balsbaugh JL, Harris MR, Findlay ES, Liu Y, Radebaugh CA, Stargell LA, Ahn NG, Whitehouse I, Luger K. DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNA replication. Elife. 2017 Mar 18; 6. PMID: 28315523.
      View in: PubMed
    4. Liu WH, Roemer SC, Zhou Y, Shen ZJ, Dennehey BK, Balsbaugh JL, Liddle JC, Nemkov T, Ahn NG, Hansen KC, Tyler JK, Churchill ME. The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones. Elife. 2016 Sep 30; 5. PMID: 27690308.
      View in: PubMed
    5. Goshen-Lago T, Goldberg-Carp A, Melamed D, Darlyuk-Saadon I, Bai C, Ahn NG, Admon A, Engelberg D. Variants of the yeast MAPK Mpk1 are fully functional independently of activation loop phosphorylation. Mol Biol Cell. 2016 Sep 01; 27(17):2771-83. PMID: 27413009; PMCID: PMC5007096 [Available on 11/16/16].
    6. Smorodinsky-Atias K, Goshen-Lago T, Goldberg-Carp A, Melamed D, Shir A, Mooshayef N, Beenstock J, Karamansha Y, Darlyuk-Saadon I, Livnah O, Ahn NG, Admon A, Engelberg D. Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylation. Mol Biol Cell. 2016 Mar 15; 27(6):1026-39. PMID: 26658610; PMCID: PMC4791124.
    7. Singh SP, Schwartz MP, Tokuda EY, Luo Y, Rogers RE, Fujita M, Ahn NG, Anseth KS. A synthetic modular approach for modeling the role of the 3D microenvironment in tumor progression. Sci Rep. 2015 Dec 07; 5:17814. PMID: 26638791; PMCID: PMC4671067.
    8. Brown R, Stuart SA, Houel S, Ahn NG, Old WM. Erratum to: Large-Scale Examination of Factors Influencing Phosphopeptide Neutral Loss During Collision Induced Dissociation. J Am Soc Mass Spectrom. 2015 Oct; 26(10):1796. PMID: 26169511.
      View in: PubMed
    9. Xiao Y, Warner LR, Latham MP, Ahn NG, Pardi A. Structure-Based Assignment of Ile, Leu, and Val Methyl Groups in the Active and Inactive Forms of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 2. Biochemistry. 2015 Jul 21; 54(28):4307-19. PMID: 26132046; PMCID: PMC4943881.
    10. Volkov VA, Grissom PM, Arzhanik VK, Zaytsev AV, Renganathan K, McClure-Begley T, Old WM, Ahn N, McIntosh JR. Centromere protein F includes two sites that couple efficiently to depolymerizing microtubules. J Cell Biol. 2015 Jun 22; 209(6):813-28. PMID: 26101217; PMCID: PMC4477864.
    11. Brown R, Stuart SA, Stuart SS, Houel S, Ahn NG, Old WM. Large-Scale Examination of Factors Influencing Phosphopeptide Neutral Loss during Collision Induced Dissociation. J Am Soc Mass Spectrom. 2015 Jul; 26(7):1128-42. PMID: 25851653; PMCID: PMC4509682.
    12. Stuart SA, Houel S, Lee T, Wang N, Old WM, Ahn NG. A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics. 2015 Jun; 14(6):1599-615. PMID: 25850435; PMCID: PMC4458723.
    13. Xiao Y, Liddle JC, Pardi A, Ahn NG. Dynamics of protein kinases: insights from nuclear magnetic resonance. Acc Chem Res. 2015 Apr 21; 48(4):1106-14. PMID: 25803188; PMCID: PMC4697736.
    14. Rudolph J, Xiao Y, Pardi A, Ahn NG. Slow inhibition and conformation selective properties of extracellular signal-regulated kinase 1 and 2 inhibitors. Biochemistry. 2015 Jan 13; 54(1):22-31. PMID: 25350931; PMCID: PMC4724192.
    15. Lee T, Wang N, Houel S, Couts K, Old W, Ahn N. Dosage and temporal thresholds in microRNA proteomics. Mol Cell Proteomics. 2015 Feb; 14(2):289-302. PMID: 25467838; PMCID: PMC4350026.
    16. Beenstock J, Ben-Yehuda S, Melamed D, Admon A, Livnah O, Ahn NG, Engelberg D. The p38ß mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the a-G helix and MAPK insert. J Biol Chem. 2014 Aug 22; 289(34):23546-56. PMID: 25006254; PMCID: PMC4156038.
    17. Sours KM, Xiao Y, Ahn NG. Extracellular-regulated kinase 2 is activated by the enhancement of hinge flexibility. J Mol Biol. 2014 May 01; 426(9):1925-35. PMID: 24534729; PMCID: PMC4001730.
    18. Xiao Y, Lee T, Latham MP, Warner LR, Tanimoto A, Pardi A, Ahn NG. Phosphorylation releases constraints to domain motion in ERK2. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2506-11. PMID: 24550275; PMCID: PMC3932853.
    19. Tracy CM, Gray AJ, Cuéllar J, Shaw TS, Howlett AC, Taylor RM, Prince JT, Ahn NG, Valpuesta JM, Willardson BM. Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate ß-tubulin folding. J Biol Chem. 2014 Feb 14; 289(7):4490-502. PMID: 24375412; PMCID: PMC3924310.
    20. Schwartz MP, Rogers RE, Singh SP, Lee JY, Loveland SG, Koepsel JT, Witze ES, Montanez-Sauri SI, Sung KE, Tokuda EY, Sharma Y, Everhart LM, Nguyen EH, Zaman MH, Beebe DJ, Ahn NG, Murphy WL, Anseth KS. A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype. PLoS One. 2013; 8(12):e81689. PMID: 24349113; PMCID: PMC3857815.
    21. Witze ES, Connacher MK, Houel S, Schwartz MP, Morphew MK, Reid L, Sacks DB, Anseth KS, Ahn NG. Wnt5a directs polarized calcium gradients by recruiting cortical endoplasmic reticulum to the cell trailing edge. Dev Cell. 2013 Sep 30; 26(6):645-57. PMID: 24091015; PMCID: PMC3884950.
    22. Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC. Structure of mediator of RhoA-dependent invasion (MRDI) explains its dual function as a metabolic enzyme and a mediator of cell invasion. Biochemistry. 2013 Aug 20; 52(33):5675-84. PMID: 23859498; PMCID: PMC3831603.
    23. Ponicsan SL, Houel S, Old WM, Ahn NG, Goodrich JA, Kugel JF. The non-coding B2 RNA binds to the DNA cleft and active-site region of RNA polymerase II. J Mol Biol. 2013 Oct 09; 425(19):3625-38. PMID: 23416138; PMCID: PMC3672349.
    24. Couts KL, Anderson EM, Gross MM, Sullivan K, Ahn NG. Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions. Oncogene. 2013 Apr 11; 32(15):1959-70. PMID: 22751131; PMCID: PMC3630485.
    25. Luo Y, Ellis LZ, Dallaglio K, Takeda M, Robinson WA, Robinson SE, Liu W, Lewis KD, McCarter MD, Gonzalez R, Norris DA, Roop DR, Spritz RA, Ahn NG, Fujita M. Side population cells from human melanoma tumors reveal diverse mechanisms for chemoresistance. J Invest Dermatol. 2012 Oct; 132(10):2440-50. PMID: 22622430; PMCID: PMC3434242.
    26. Wang D, Zhang Z, O'Loughlin E, Lee T, Houel S, O'Carroll D, Tarakhovsky A, Ahn NG, Yi R. Quantitative functions of Argonaute proteins in mammalian development. Genes Dev. 2012 Apr 01; 26(7):693-704. PMID: 22474261; PMCID: PMC3323880.
    27. Oyeyemi OA, Sours KM, Lee T, Kohen A, Resing KA, Ahn NG, Klinman JP. Comparative hydrogen-deuterium exchange for a mesophilic vs thermophilic dihydrofolate reductase at 25 °C: identification of a single active site region with enhanced flexibility in the mesophilic protein. Biochemistry. 2011 Sep 27; 50(38):8251-60. PMID: 21859100; PMCID: PMC3180199.
    28. Meyer-Arendt K, Old WM, Houel S, Renganathan K, Eichelberger B, Resing KA, Ahn NG. IsoformResolver: A peptide-centric algorithm for protein inference. J Proteome Res. 2011 Jul 01; 10(7):3060-75. PMID: 21599010; PMCID: PMC3167374.
    29. Yen CY, Houel S, Ahn NG, Old WM. Spectrum-to-spectrum searching using a proteome-wide spectral library. Mol Cell Proteomics. 2011 Jul; 10(7):M111.007666. PMID: 21532008; PMCID: PMC3134071.
    30. Ring AY, Sours KM, Lee T, Ahn NG. Distinct patterns of activation-dependent changes in conformational mobility between ERK1 and ERK2. Int J Mass Spectrom. 2011 Apr; 302(1-3):101-109. PMID: 21785572.
      View in: PubMed
    31. Houel S, Abernathy R, Renganathan K, Meyer-Arendt K, Ahn NG, Old WM. Quantifying the impact of chimera MS/MS spectra on peptide identification in large-scale proteomics studies. J Proteome Res. 2010 Aug 06; 9(8):4152-60. PMID: 20578722; PMCID: PMC3221600.
    32. Oyeyemi OA, Sours KM, Lee T, Resing KA, Ahn NG, Klinman JP. Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10074-9. PMID: 20534574; PMCID: PMC2890430.
    33. Prince JT, Ahn NG. The case of the disappearing drug target. Mol Cell. 2010 Feb 26; 37(4):455-6. PMID: 20188664.
      View in: PubMed
    34. Sours KM, Ahn NG. Analysis of MAP kinases by hydrogen exchange mass spectrometry. Methods Mol Biol. 2010; 661:239-55. PMID: 20811987; PMCID: PMC3252998.
    35. Ahn NG. PORE-ing over ERK substrates. Nat Struct Mol Biol. 2009 Oct; 16(10):1004-5. PMID: 19809488.
      View in: PubMed
    36. Wang W, Yang Y, Gao Y, Xu Q, Wang F, Zhu S, Old W, Resing K, Ahn N, Lei M, Liu X. Structural and mechanistic insights into Mps1 kinase activation. J Cell Mol Med. 2009 Aug; 13(8B):1679-94. PMID: 19120698; PMCID: PMC2829362.
    37. Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. Mol Cell Proteomics. 2009 Oct; 8(10):2308-20. PMID: 19620624; PMCID: PMC2758758.
    38. Argast GM, Croy CH, Couts KL, Zhang Z, Litman E, Chan DC, Ahn NG. Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells. Oncogene. 2009 Jul 30; 28(30):2697-709. PMID: 19483722; PMCID: PMC3238492.
    39. Old WM, Shabb JB, Houel S, Wang H, Couts KL, Yen CY, Litman ES, Croy CH, Meyer-Arendt K, Miranda JG, Brown RA, Witze ES, Schweppe RE, Resing KA, Ahn NG. Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. Mol Cell. 2009 Apr 10; 34(1):115-31. PMID: 19362540; PMCID: PMC2735263.
    40. Yen CY, Meyer-Arendt K, Eichelberger B, Sun S, Houel S, Old WM, Knight R, Ahn NG, Hunter LE, Resing KA. A simulated MS/MS library for spectrum-to-spectrum searching in large scale identification of proteins. Mol Cell Proteomics. 2009 Apr; 8(4):857-69. PMID: 19106086; PMCID: PMC2667364.
    41. Gehrke A, Sun S, Kurgan L, Ahn N, Resing K, Kafadar K, Cios K. Improved machine learning method for analysis of gas phase chemistry of peptides. BMC Bioinformatics. 2008 Dec 03; 9:515. PMID: 19055745; PMCID: PMC2612015.
    42. Xu Q, Zhu S, Wang W, Zhang X, Old W, Ahn N, Liu X. Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. Mol Biol Cell. 2009 Jan; 20(1):10-20. PMID: 18923149; PMCID: PMC2613107.
    43. Levin-Salomon V, Kogan K, Ahn NG, Livnah O, Engelberg D. Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases. J Biol Chem. 2008 Dec 12; 283(50):34500-10. PMID: 18829462; PMCID: PMC3259889.
    44. Sours KM, Kwok SC, Rachidi T, Lee T, Ring A, Hoofnagle AN, Resing KA, Ahn NG. Hydrogen-exchange mass spectrometry reveals activation-induced changes in the conformational mobility of p38alpha MAP kinase. J Mol Biol. 2008 Jun 20; 379(5):1075-93. PMID: 18501927; PMCID: PMC2782421.
    45. Witze ES, Litman ES, Argast GM, Moon RT, Ahn NG. Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science. 2008 Apr 18; 320(5874):365-9. PMID: 18420933; PMCID: PMC3229220.
    46. Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A. Human Proteinpedia enables sharing of human protein data. Nat Biotechnol. 2008 Feb; 26(2):164-7. PMID: 18259167.
      View in: PubMed
    47. Witze ES, Old WM, Resing KA, Ahn NG. Mapping protein post-translational modifications with mass spectrometry. Nat Methods. 2007 Oct; 4(10):798-806. PMID: 17901869.
      View in: PubMed
    48. Mattison CP, Old WM, Steiner E, Huneycutt BJ, Resing KA, Ahn NG, Winey M. Mps1 activation loop autophosphorylation enhances kinase activity. J Biol Chem. 2007 Oct 19; 282(42):30553-61. PMID: 17728254.
      View in: PubMed
    49. Ahn NG, Shabb JB, Old WM, Resing KA. Achieving in-depth proteomics profiling by mass spectrometry. ACS Chem Biol. 2007 Jan 23; 2(1):39-52. PMID: 17243782.
      View in: PubMed
    50. Emrick MA, Lee T, Starkey PJ, Mumby MC, Resing KA, Ahn NG. The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18101-6. PMID: 17114285; PMCID: PMC1838713.
    51. Shi Z, Resing KA, Ahn NG. Networks for the allosteric control of protein kinases. Curr Opin Struct Biol. 2006 Dec; 16(6):686-92. PMID: 17085044.
      View in: PubMed
    52. Sun S, Meyer-Arendt K, Eichelberger B, Brown R, Yen CY, Old WM, Pierce K, Cios KJ, Ahn NG, Resing KA. Improved validation of peptide MS/MS assignments using spectral intensity prediction. Mol Cell Proteomics. 2007 Jan; 6(1):1-17. PMID: 17018520.
      View in: PubMed
    53. Roberts EC, Hammond K, Traish AM, Resing KA, Ahn NG. Identification of G2/M targets for the MAP kinase pathway by functional proteomics. Proteomics. 2006 Aug; 6(16):4541-53. PMID: 16858730.
      View in: PubMed
    54. Schweppe RE, Cheung TH, Ahn NG. Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses. J Biol Chem. 2006 Jul 28; 281(30):20993-1003. PMID: 16735500.
      View in: PubMed
    55. Kabuyama Y, Langer SJ, Polvinen K, Homma Y, Resing KA, Ahn NG. Functional proteomics identifies protein-tyrosine phosphatase 1B as a target of RhoA signaling. Mol Cell Proteomics. 2006 Aug; 5(8):1359-67. PMID: 16644720.
      View in: PubMed
    56. Ma Z, Izumi H, Kanai M, Kabuyama Y, Ahn NG, Fukasawa K. Mortalin controls centrosome duplication via modulating centrosomal localization of p53. Oncogene. 2006 Aug 31; 25(39):5377-90. PMID: 16619038.
      View in: PubMed
    57. Ruth MC, Xu Y, Maxwell IH, Ahn NG, Norris DA, Shellman YG. RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway. J Invest Dermatol. 2006 Apr; 126(4):862-8. PMID: 16470169.
      View in: PubMed
    58. Ruth MC, Old WM, Emrick MA, Meyer-Arendt K, Aveline-Wolf LD, Pierce KG, Mendoza AM, Sevinsky JR, Hamady M, Knight RD, Resing KA, Ahn NG. Analysis of membrane proteins from human chronic myelogenous leukemia cells: comparison of extraction methods for multidimensional LC-MS/MS. J Proteome Res. 2006 Mar; 5(3):709-19. PMID: 16512687.
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    59. Yen CY, Russell S, Mendoza AM, Meyer-Arendt K, Sun S, Cios KJ, Ahn NG, Resing KA. Improving sensitivity in shotgun proteomics using a peptide-centric database with reduced complexity: protease cleavage and SCX elution rules from data mining of MS/MS spectra. Anal Chem. 2006 Feb 15; 78(4):1071-84. PMID: 16478097.
      View in: PubMed
    60. Downer J, Sevinsky JR, Ahn NG, Resing KA, Betterton MD. Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase. J Theor Biol. 2006 Jun 07; 240(3):464-74. PMID: 16325864.
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    61. Lee T, Hoofnagle AN, Resing KA, Ahn NG. Hydrogen exchange solvent protection by an ATP analogue reveals conformational changes in ERK2 upon activation. J Mol Biol. 2005 Oct 28; 353(3):600-12. PMID: 16185715.
      View in: PubMed
    62. Old WM, Meyer-Arendt K, Aveline-Wolf L, Pierce KG, Mendoza A, Sevinsky JR, Resing KA, Ahn NG. Comparison of label-free methods for quantifying human proteins by shotgun proteomics. Mol Cell Proteomics. 2005 Oct; 4(10):1487-502. PMID: 15979981.
      View in: PubMed
    63. Ahn NG, Resing KA. Cell biology. Lessons in rational drug design for protein kinases. Science. 2005 May 27; 308(5726):1266-7. PMID: 15919981.
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    64. Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Pérez-Rosado A, Calvo E, Lopez JA, Cano A, Calasanz MJ, Colomer D, Piris MA, Ahn N, Imhof A, Caldas C, Jenuwein T, Esteller M. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet. 2005 Apr; 37(4):391-400. PMID: 15765097.
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    65. Resing KA, Ahn NG. Proteomics strategies for protein identification. FEBS Lett. 2005 Feb 07; 579(4):885-9. PMID: 15680968.
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    66. Liang ZX, Tsigos I, Lee T, Bouriotis V, Resing KA, Ahn NG, Klinman JP. Evidence for increased local flexibility in psychrophilic alcohol dehydrogenase relative to its thermophilic homologue. Biochemistry. 2004 Nov 23; 43(46):14676-83. PMID: 15544338.
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    67. Kabuyama Y, Resing KA, Ahn NG. Applying proteomics to signaling networks. Curr Opin Genet Dev. 2004 Oct; 14(5):492-8. PMID: 15380239.
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    68. Jaspersen SL, Huneycutt BJ, Giddings TH, Resing KA, Ahn NG, Winey M. Cdc28/Cdk1 regulates spindle pole body duplication through phosphorylation of Spc42 and Mps1. Dev Cell. 2004 Aug; 7(2):263-74. PMID: 15296722.
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    69. Resing KA, Meyer-Arendt K, Mendoza AM, Aveline-Wolf LD, Jonscher KR, Pierce KG, Old WM, Cheung HT, Russell S, Wattawa JL, Goehle GR, Knight RD, Ahn NG. Improving reproducibility and sensitivity in identifying human proteins by shotgun proteomics. Anal Chem. 2004 Jul 01; 76(13):3556-68. PMID: 15228325.
      View in: PubMed
    70. Liang ZX, Lee T, Resing KA, Ahn NG, Klinman JP. Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9556-61. PMID: 15210941; PMCID: PMC470713.
    71. Sevinsky JR, Whalen AM, Ahn NG. Extracellular signal-regulated kinase induces the megakaryocyte GPIIb/CD41 gene through MafB/Kreisler. Mol Cell Biol. 2004 May; 24(10):4534-45. PMID: 15121870; PMCID: PMC400447.
    72. Lee T, Hoofnagle AN, Kabuyama Y, Stroud J, Min X, Goldsmith EJ, Chen L, Resing KA, Ahn NG. Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry. Mol Cell. 2004 Apr 09; 14(1):43-55. PMID: 15068802.
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    73. Bernard KR, Jonscher KR, Resing KA, Ahn NG. Methods in functional proteomics: two-dimensional polyacrylamide gel electrophoresis with immobilized pH gradients, in-gel digestion and identification of proteins by mass spectrometry. Methods Mol Biol. 2004; 250:263-82. PMID: 14755094.
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    74. Hoofnagle AN, Stoner JW, Lee T, Eaton SS, Ahn NG. Phosphorylation-dependent changes in structure and dynamics in ERK2 detected by SDSL and EPR. Biophys J. 2004 Jan; 86(1 Pt 1):395-403. PMID: 14695281; PMCID: PMC1303804.
    75. Hoofnagle AN, Resing KA, Ahn NG. Practical methods for deuterium exchange/mass spectrometry. Methods Mol Biol. 2004; 250:283-98. PMID: 14755095.
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    76. Kabuyama Y, Polvinen KK, Resing KA, Ahn NG. Two-dimensional gel electrophoresis for the identification of signaling targets. Methods Mol Biol. 2004; 284:37-49. PMID: 15173607.
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    77. Bernard K, Litman E, Fitzpatrick JL, Shellman YG, Argast G, Polvinen K, Everett AD, Fukasawa K, Norris DA, Ahn NG, Resing KA. Functional proteomic analysis of melanoma progression. Cancer Res. 2003 Oct 15; 63(20):6716-25. PMID: 14583466.
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    78. Galasinski SC, Resing KA, Ahn NG. Protein mass analysis of histones. Methods. 2003 Sep; 31(1):3-11. PMID: 12893168.
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    79. Haydon CE, Eyers PA, Aveline-Wolf LD, Resing KA, Maller JL, Ahn NG. Identification of novel phosphorylation sites on Xenopus laevis Aurora A and analysis of phosphopeptide enrichment by immobilized metal-affinity chromatography. Mol Cell Proteomics. 2003 Oct; 2(10):1055-67. PMID: 12885952.
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    80. Schweppe RE, Haydon CE, Lewis TS, Resing KA, Ahn NG. The characterization of protein post-translational modifications by mass spectrometry. Acc Chem Res. 2003 Jun; 36(6):453-61. PMID: 12809532.
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    81. Schweppe RE, Melton AA, Brodsky KS, Aveline LD, Resing KA, Ahn NG, Gutierrez-Hartmann A. Purification and mass spectrometric identification of GA-binding protein (GABP) as the functional pituitary Ets factor binding to the basal transcription element of the prolactin promoter. J Biol Chem. 2003 May 09; 278(19):16863-72. PMID: 12618435.
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    82. Hoofnagle AN, Resing KA, Ahn NG. Protein analysis by hydrogen exchange mass spectrometry. Annu Rev Biophys Biomol Struct. 2003; 32:1-25. PMID: 12598366.
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    83. Roberts EC, Shapiro PS, Nahreini TS, Pages G, Pouyssegur J, Ahn NG. Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis. Mol Cell Biol. 2002 Oct; 22(20):7226-41. PMID: 12242299; PMCID: PMC139798.
    84. Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12085-90. PMID: 12196628; PMCID: PMC129402.
    85. Vaish NK, Dong F, Andrews L, Schweppe RE, Ahn NG, Blatt L, Seiwert SD. Monitoring post-translational modification of proteins with allosteric ribozymes. Nat Biotechnol. 2002 Aug; 20(8):810-5. PMID: 12118241.
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    86. McLaughlin JN, Thulin CD, Hart SJ, Resing KA, Ahn NG, Willardson BM. Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):7962-7. PMID: 12060742; PMCID: PMC123003.
    87. Galasinski SC, Resing KA, Goodrich JA, Ahn NG. Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactions. J Biol Chem. 2002 May 31; 277(22):19618-26. PMID: 11919195.
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    88. Galasinski SC, Louie DF, Gloor KK, Resing KA, Ahn NG. Global regulation of post-translational modifications on core histones. J Biol Chem. 2002 Jan 25; 277(4):2579-88. PMID: 11709551.
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    89. Sharma P, Sharma M, Amin ND, Sihag RK, Grant P, Ahn N, Kulkarni AB, Pant HC. Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. J Biol Chem. 2002 Jan 04; 277(1):528-34. PMID: 11684694.
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    90. Emrick MA, Hoofnagle AN, Miller AS, Ten Eyck LF, Ahn NG. Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations. J Biol Chem. 2001 Dec 07; 276(49):46469-79. PMID: 11591711.
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    91. Jesch SA, Lewis TS, Ahn NG, Linstedt AD. Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2. Mol Biol Cell. 2001 Jun; 12(6):1811-7. PMID: 11408587; PMCID: PMC37343.
    92. Thulin CD, Savage JR, McLaughlin JN, Truscott SM, Old WM, Ahn NG, Resing KA, Hamm HE, Bitensky MW, Willardson BM. Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding. J Biol Chem. 2001 Jun 29; 276(26):23805-15. PMID: 11331285.
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    93. Ahn NG, Resing KA. Toward the phosphoproteome. Nat Biotechnol. 2001 Apr; 19(4):317-8. PMID: 11283582.
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    94. Friedman DB, Kern JW, Huneycutt BJ, Vinh DB, Crawford DK, Steiner E, Scheiltz D, Yates J, Resing KA, Ahn NG, Winey M, Davis TN. Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain. J Biol Chem. 2001 May 25; 276(21):17958-67. PMID: 11278681; PMCID: PMC4013285.
    95. Hoofnagle AN, Resing KA, Goldsmith EJ, Ahn NG. Changes in protein conformational mobility upon activation of extracellular regulated protein kinase-2 as detected by hydrogen exchange. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):956-61. PMID: 11158577; PMCID: PMC14691.
    96. Ahn NG, Nahreini TS, Tolwinski NS, Resing KA. Pharmacologic inhibitors of MKK1 and MKK2. Methods Enzymol. 2001; 332:417-31. PMID: 11305115.
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    97. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG. Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Mol Cell. 2000 Dec; 6(6):1343-54. PMID: 11163208.
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    98. Seiwert SD, Stines Nahreini T, Aigner S, Ahn NG, Uhlenbeck OC. RNA aptamers as pathway-specific MAP kinase inhibitors. Chem Biol. 2000 Nov; 7(11):833-43. PMID: 11094337.
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    99. Prowse CN, Hagopian JC, Cobb MH, Ahn NG, Lew J. Catalytic reaction pathway for the mitogen-activated protein kinase ERK2. Biochemistry. 2000 May 23; 39(20):6258-66. PMID: 10821702.
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    100. Rak J, Mitsuhashi Y, Sheehan C, Tamir A, Viloria-Petit A, Filmus J, Mansour SJ, Ahn NG, Kerbel RS. Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts. Cancer Res. 2000 Jan 15; 60(2):490-8. PMID: 10667605.
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    101. Louie DF, Gloor KK, Galasinski SC, Resing KA, Ahn NG. Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry. Protein Sci. 2000 Jan; 9(1):170-9. PMID: 10739259; PMCID: PMC2144438.
    102. Holmström TH, Tran SE, Johnson VL, Ahn NG, Chow SC, Eriksson JE. Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis. Mol Cell Biol. 1999 Sep; 19(9):5991-6002. PMID: 10454546; PMCID: PMC84476.
    103. Resing KA, Hoofnagle AN, Ahn NG. Modeling deuterium exchange behavior of ERK2 using pepsin mapping to probe secondary structure. J Am Soc Mass Spectrom. 1999 Aug; 10(8):685-702. PMID: 10439507.
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    104. Forsberg EC, Zaboikina TN, Versaw WK, Ahn NG, Bresnick EH. Enhancement of beta-globin locus control region-mediated transactivation by mitogen-activated protein kinases through stochastic and graded mechanisms. Mol Cell Biol. 1999 Aug; 19(8):5565-75. PMID: 10409746; PMCID: PMC84409.
    105. Boeshans KM, Resing KA, Hunt JB, Ahn NG, Shabb JB. Structural characterization of the membrane-associated regulatory subunit of type I cAMP-dependent protein kinase by mass spectrometry: identification of Ser81 as the in vivo phosphorylation site of RIalpha. Protein Sci. 1999 Jul; 8(7):1515-22. PMID: 10422841; PMCID: PMC2144381.
    106. Shapiro PS, Whalen AM, Tolwinski NS, Wilsbacher J, Froelich-Ammon SJ, Garcia M, Osheroff N, Ahn NG. Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation. Mol Cell Biol. 1999 May; 19(5):3551-60. PMID: 10207078; PMCID: PMC84147.
    107. Tolwinski NS, Shapiro PS, Goueli S, Ahn NG. Nuclear localization of mitogen-activated protein kinase kinase 1 (MKK1) is promoted by serum stimulation and G2-M progression. Requirement for phosphorylation at the activation lip and signaling downstream of MKK. J Biol Chem. 1999 Mar 05; 274(10):6168-74. PMID: 10037701.
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    108. Resing KA, Ahn NG. Applications of mass spectrometry to signal transduction. Prog Biophys Mol Biol. 1999; 71(3-4):501-23. PMID: 10354711.
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    109. Shapiro PS, Vaisberg E, Hunt AJ, Tolwinski NS, Whalen AM, McIntosh JR, Ahn NG. Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen. J Cell Biol. 1998 Sep 21; 142(6):1533-45. PMID: 9744882; PMCID: PMC2141760.
    110. Biggs JR, Ahn NG, Kraft AS. Activation of the mitogen-activated protein kinase pathway in U937 leukemic cells induces phosphorylation of the amino terminus of the TATA-binding protein. Cell Growth Differ. 1998 Aug; 9(8):667-76. PMID: 9716183.
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    111. Amin ND, Ahn NG, Jaffe H, Winters CA, Grant P, Pant HC. Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M. J Neurosci. 1998 Jun 01; 18(11):4008-21. PMID: 9592082.
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    112. Duesbery NS, Webb CP, Leppla SH, Gordon VM, Klimpel KR, Copeland TD, Ahn NG, Oskarsson MK, Fukasawa K, Paull KD, Vande Woude GF. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science. 1998 May 01; 280(5364):734-7. PMID: 9563949.
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    113. Shapiro PS, Ahn NG. Feedback regulation of Raf-1 and mitogen-activated protein kinase (MAP) kinase kinases 1 and 2 by MAP kinase phosphatase-1 (MKP-1). J Biol Chem. 1998 Jan 16; 273(3):1788-93. PMID: 9430728.
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    114. Resing KA, Ahn NG. Deuterium exchange mass spectrometry as a probe of protein kinase activation. Analysis of wild-type and constitutively active mutants of MAP kinase kinase-1. Biochemistry. 1998 Jan 13; 37(2):463-75. PMID: 9425067.
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    115. Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res. 1998; 74:49-139. PMID: 9561267.
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    116. Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J. 1997 Nov 03; 16(21):6426-38. PMID: 9351825; PMCID: PMC1170249.
    117. Font de Mora J, Porras A, Ahn N, Santos E. Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation. Mol Cell Biol. 1997 Oct; 17(10):6068-75. PMID: 9315666; PMCID: PMC232456.
    118. Whalen SG, Marcellus RC, Whalen A, Ahn NG, Ricciardi RP, Branton PE. Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4. J Virol. 1997 May; 71(5):3545-53. PMID: 9094626; PMCID: PMC191501.
    119. Whalen AM, Galasinski SC, Shapiro PS, Nahreini TS, Ahn NG. Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase. Mol Cell Biol. 1997 Apr; 17(4):1947-58. PMID: 9121442; PMCID: PMC232041.
    120. Resing KA, Ahn NG. Protein phosphorylation analysis by electrospray ionization-mass spectrometry. Methods Enzymol. 1997; 283:29-44. PMID: 9251009.
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    121. Mansour SJ, Candia JM, Matsuura JE, Manning MC, Ahn NG. Interdependent domains controlling the enzymatic activity of mitogen-activated protein kinase kinase 1. Biochemistry. 1996 Dec 03; 35(48):15529-36. PMID: 8952507.
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    122. Robinson MJ, Cheng M, Khokhlatchev A, Ebert D, Ahn N, Guan KL, Stein B, Goldsmith E, Cobb MH. Contributions of the mitogen-activated protein (MAP) kinase backbone and phosphorylation loop to MEK specificity. J Biol Chem. 1996 Nov 22; 271(47):29734-9. PMID: 8939908.
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    123. Louie DF, Resing KA, Lewis TS, Ahn NG. Mass spectrometric analysis of 40 S ribosomal proteins from Rat-1 fibroblasts. J Biol Chem. 1996 Nov 08; 271(45):28189-98. PMID: 8910435.
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    124. Matten WT, Copeland TD, Ahn NG, Vande Woude GF. Positive feedback between MAP kinase and Mos during Xenopus oocyte maturation. Dev Biol. 1996 Nov 01; 179(2):485-92. PMID: 8903362.
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    125. Voyno-Yasenetskaya TA, Faure MP, Ahn NG, Bourne HR. Galpha12 and Galpha13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells. J Biol Chem. 1996 Aug 30; 271(35):21081-7. PMID: 8702875.
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    126. Choi T, Rulong S, Resau J, Fukasawa K, Matten W, Kuriyama R, Mansour S, Ahn N, Vande Woude GF. Mos/mitogen-activated protein kinase can induce early meiotic phenotypes in the absence of maturation-promoting factor: a novel system for analyzing spindle formation during meiosis I. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4730-5. PMID: 8643471; PMCID: PMC39347.
    127. Mansour SJ, Candia JM, Gloor KK, Ahn NG. Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses. Cell Growth Differ. 1996 Feb; 7(2):243-50. PMID: 8822208.
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    128. Bokemeyer D, Sorokin A, Yan M, Ahn NG, Templeton DJ, Dunn MJ. Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts. J Biol Chem. 1996 Jan 12; 271(2):639-42. PMID: 8557667.
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    129. Thorburn J, Carlson M, Mansour SJ, Chien KR, Ahn NG, Thorburn A. Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase. Mol Biol Cell. 1995 Nov; 6(11):1479-90. PMID: 8589450; PMCID: PMC301305.
    130. al-Alawi N, Rose DW, Buckmaster C, Ahn N, Rapp U, Meinkoth J, Feramisco JR. Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the Raf-dependent cytoplasmic kinase cascade. Mol Cell Biol. 1995 Mar; 15(3):1162-8. PMID: 7862110; PMCID: PMC230338.
    131. Resing KA, Mansour SJ, Hermann AS, Johnson RS, Candia JM, Fukasawa K, Vande Woude GF, Ahn NG. Determination of v-Mos-catalyzed phosphorylation sites and autophosphorylation sites on MAP kinase kinase by ESI/MS. Biochemistry. 1995 Feb 28; 34(8):2610-20. PMID: 7873542.
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    132. Markowitz RB, Hermann AS, Taylor DF, He L, Anthony-Cahill S, Ahn NG, Dynan WS. Phosphorylation of the C-terminal domain of RNA polymerase II by the extracellular-signal-regulated protein kinase ERK2. Biochem Biophys Res Commun. 1995 Feb 27; 207(3):1051-7. PMID: 7864892.
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    133. Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, Vande Woude GF, Ahn NG. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science. 1994 Aug 12; 265(5174):966-70. PMID: 8052857.
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    134. Mansour SJ, Resing KA, Candi JM, Hermann AS, Gloor JW, Herskind KR, Wartmann M, Davis RJ, Ahn NG. Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis. J Biochem. 1994 Aug; 116(2):304-14. PMID: 7822248.
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    135. Yonemura K, Raines EW, Ahn NG, Narayanan AS. Mitogenic signaling mechanisms of human cementum-derived growth factors. J Biol Chem. 1993 Dec 15; 268(35):26120-6. PMID: 8253729.
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    136. Ahn NG. The MAP kinase cascade. Discovery of a new signal transduction pathway. Mol Cell Biochem. 1993 Nov; 127-128:201-9. PMID: 7935352.
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    137. Gause KC, Homma MK, Licciardi KA, Seger R, Ahn NG, Peterson MJ, Krebs EG, Meier KE. Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells. J Biol Chem. 1993 Aug 05; 268(22):16124-9. PMID: 8344897.
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    138. Genot EM, Meier KE, Licciardi KA, Ahn NG, Uittenbogaart CH, Wietzerbin J, Clark EA, Valentine MA. Phosphorylation of CD20 in cells from a hairy cell leukemia cell line. Evidence for involvement of calcium/calmodulin-dependent protein kinase II. J Immunol. 1993 Jul 01; 151(1):71-82. PMID: 7686949.
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    139. Ahn NG, Campbell JS, Seger R, Jensen AL, Graves LM, Krebs EG. Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5143-7. PMID: 8389470; PMCID: PMC46671.
    140. Posada J, Yew N, Ahn NG, Vande Woude GF, Cooper JA. Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro. Mol Cell Biol. 1993 Apr; 13(4):2546-53. PMID: 8384311; PMCID: PMC359584.
    141. Krebs EG, Ahn NG, Campbell JS, Graves LM, Seger R, Weiel JE. Regulation of protein serine/threonine kinases by tyrosine kinases. Adv Second Messenger Phosphoprotein Res. 1993; 28:227-36. PMID: 8398408.
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    142. Seger R, Seger D, Lozeman FJ, Ahn NG, Graves LM, Campbell JS, Ericsson L, Harrylock M, Jensen AM, Krebs EG. Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. J Biol Chem. 1992 Dec 25; 267(36):25628-31. PMID: 1281467.
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    143. Ahn NG, Seger R, Krebs EG. The mitogen-activated protein kinase activator. Curr Opin Cell Biol. 1992 Dec; 4(6):992-9. PMID: 1485970.
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    144. Seger R, Ahn NG, Posada J, Munar ES, Jensen AM, Cooper JA, Cobb MH, Krebs EG. Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. J Biol Chem. 1992 Jul 15; 267(20):14373-81. PMID: 1321146.
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    145. Ahn NG, Robbins DJ, Haycock JW, Seger R, Cobb MH, Krebs EG. Identification of an activator of the microtubule-associated protein 2 kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin. J Neurochem. 1992 Jul; 59(1):147-56. PMID: 1319464.
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    146. Haycock JW, Ahn NG, Cobb MH, Krebs EG. ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2365-9. PMID: 1347949; PMCID: PMC48658.
    147. Ahn NG, Seger R, Bratlien RL, Krebs EG. Growth factor-stimulated phosphorylation cascades: activation of growth factor-stimulated MAP kinase. Ciba Found Symp. 1992; 164:113-26; discussion 126-31. PMID: 1327676.
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    148. Seger R, Ahn NG, Boulton TG, Yancopoulos GD, Panayotatos N, Radziejewska E, Ericsson L, Bratlien RL, Cobb MH, Krebs EG. Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6142-6. PMID: 1712480; PMCID: PMC52038.
    149. Ahn NG, Seger R, Bratlien RL, Diltz CD, Tonks NK, Krebs EG. Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. J Biol Chem. 1991 Mar 05; 266(7):4220-7. PMID: 1705548.
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    150. Ahn NG, Weiel JE, Chan CP, Krebs EG. Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells. J Biol Chem. 1990 Jul 15; 265(20):11487-94. PMID: 2142153.
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    151. Ahn NG, Krebs EG. Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro. J Biol Chem. 1990 Jul 15; 265(20):11495-501. PMID: 2142154.
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    152. Weiel JE, Ahn NG, Seger R, Krebs EG. Communication between protein tyrosine and protein serine/threonine phosphorylation. Adv Second Messenger Phosphoprotein Res. 1990; 24:182-95. PMID: 2169797.
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    153. Ahn NG, Klinman JP. Activation of dopamine beta-monooxygenase by external and internal electron donors in resealed chromaffin granule ghosts. J Biol Chem. 1987 Feb 05; 262(4):1485-92. PMID: 3805036.
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    154. Ahn N, Klinman JP. Mechanism of modulation of dopamine beta-monooxygenase by pH and fumarate as deduced from initial rate and primary deuterium isotope effect studies. Biochemistry. 1983 Jun 21; 22(13):3096-106. PMID: 6882739.
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