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Sonia Flores

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Address2RC2
Research 2
12700 East 19th Avenue - Mail Stop 8619
Aurora CO 80045
Phone303/724-6084

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Neff CP, Chain JL, MaWhinney S, Martin AK, Linderman DJ, Flores SC, Campbell TB, Palmer BE, Fontenot AP. Lymphocytic Alveolitis Is Associated with the Accumulation of Functionally Impaired HIV-Specific T Cells in the Lung of Antiretroviral Therapy-Naive Subjects. Am J Respir Crit Care Med. 2015 Feb 15; 191(4):464-73.
      View in: PubMed
    2. Honda JR, Connick E, MaWhinney S, Chan ED, Flores SC. Plasma LL-37 correlates with vitamin D and is reduced in human immunodeficiency virus-1 infected individuals not receiving antiretroviral therapy. J Med Microbiol. 2014 Jul; 63(Pt 7):997-1003.
      View in: PubMed
    3. Wang T, Green LA, Gupta SK, Kim C, Wang L, Almodovar S, Flores SC, Prudovsky IA, Jolicoeur P, Liu Z, Clauss M. Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction. PLoS One. 2014; 9(3):e91063.
      View in: PubMed
    4. Martin RJ, Flores S, Kraft M. The lung microbiome. A new frontier in pulmonary medicine: introduction and perspective. Ann Am Thorac Soc. 2014 Jan; 11 Suppl 1:S1-2.
      View in: PubMed
    5. Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b is required for airway defence. Nature. 2014 Jan 16; 505(7483):412-6.
      View in: PubMed
    6. Lozupone CA, Li M, Campbell TB, Flores SC, Linderman D, Gebert MJ, Knight R, Fontenot AP, Palmer BE. Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe. 2013 Sep 11; 14(3):329-39.
      View in: PubMed
    7. Morris A, Beck JM, Schloss PD, Campbell TB, Crothers K, Curtis JL, Flores SC, Fontenot AP, Ghedin E, Huang L, Jablonski K, Kleerup E, Lynch SV, Sodergren E, Twigg H, Young VB, Bassis CM, Venkataraman A, Schmidt TM, Weinstock GM. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med. 2013 May 15; 187(10):1067-75.
      View in: PubMed
    8. Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, Young VB, Lynch SV, Huang L, Weinstock GM, Knox KS, Twigg H, Morris A, Ghedin E, Bushman FD, Collman RG, Knight R, Fontenot AP. Widespread colonization of the lung by Tropheryma whipplei in HIV infection. Am J Respir Crit Care Med. 2013 May 15; 187(10):1110-7.
      View in: PubMed
    9. Flores SC, Almodovar S. Human immunodeficiency virus, herpes virus infections, and pulmonary vascular disease. Pulm Circ. 2013 Jan; 3(1):165-70.
      View in: PubMed
    10. Almodovar S, Knight R, Allshouse AA, Roemer S, Lozupone C, McDonald D, Widmann J, Voelkel NF, Shelton RJ, Suarez EB, Hammer KW, Goujard C, Petrosillo N, Simonneau G, Hsue PY, Humbert M, Flores SC. Human Immunodeficiency Virus nef signature sequences are associated with pulmonary hypertension. AIDS Res Hum Retroviruses. 2012 Jun; 28(6):607-18.
      View in: PubMed
    11. Honda JR, Shang S, Shanley CA, Caraway ML, Henao-Tamayo M, Chan ED, Basaraba RJ, Orme IM, Ordway DJ, Flores SC. Immune Responses of HIV-1 Tat Transgenic Mice to Mycobacterium Tuberculosis W-Beijing SA161. Open AIDS J. 2011; 5:86-95.
      View in: PubMed
    12. Cota-Gomez A, Flores AC, Ling XF, Varella-Garcia M, Flores SC. HIV-1 Tat increases oxidant burden in the lungs of transgenic mice. Free Radic Biol Med. 2011 Nov 1; 51(9):1697-707.
      View in: PubMed
    13. Crothers K, Thompson BW, Burkhardt K, Morris A, Flores SC, Diaz PT, Chaisson RE, Kirk GD, Rom WN, Huang L. HIV-associated lung infections and complications in the era of combination antiretroviral therapy. Proc Am Thorac Soc. 2011 Jun; 8(3):275-81.
      View in: PubMed
    14. Almodovar S, Hsue PY, Morelli J, Huang L, Flores SC. Pathogenesis of HIV-associated pulmonary hypertension: potential role of HIV-1 Nef. Proc Am Thorac Soc. 2011 Jun; 8(3):308-12.
      View in: PubMed
    15. Zimmerman MA, Haskins K, Bradley B, Gilman J, Gamboni-Robertson F, Flores SC. Autoimmune-mediated vascular injury occurs prior to sustained hyperglycemia in a murine model of type I diabetes mellitus. J Surg Res. 2011 Jun 15; 168(2):e195-202.
      View in: PubMed
    16. Lee JE, Patel K, Almodóvar S, Tuder RM, Flores SC, Sehgal PB. Dependence of Golgi apparatus integrity on nitric oxide in vascular cells: implications in pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2011 Apr; 300(4):H1141-58.
      View in: PubMed
    17. Almodovar S, Cicalini S, Petrosillo N, Flores SC. Pulmonary hypertension associated with HIV infection: pulmonary vascular disease: the global perspective. Chest. 2010 Jun; 137(6 Suppl):6S-12S.
      View in: PubMed
    18. Sehgal PB, Mukhopadhyay S, Patel K, Xu F, Almodóvar S, Tuder RM, Flores SC. Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L729-37.
      View in: PubMed
    19. Hassoun PM, Mouthon L, Barberà JA, Eddahibi S, Flores SC, Grimminger F, Jones PL, Maitland ML, Michelakis ED, Morrell NW, Newman JH, Rabinovitch M, Schermuly R, Stenmark KR, Voelkel NF, Yuan JX, Humbert M. Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S10-9.
      View in: PubMed
    20. Irwin DC, McCord JM, Nozik-Grayck E, Beckly G, Foreman B, Sullivan T, White M, T Crossno J, Bailey D, Flores SC, Majka S, Klemm D, van Patot MC. A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak. Free Radic Biol Med. 2009 Jul 1; 47(1):55-61.
      View in: PubMed
    21. Voelkel NF, Cool CD, Flores S. From viral infection to pulmonary arterial hypertension: a role for viral proteins? AIDS. 2008 Sep; 22 Suppl 3:S49-53.
      View in: PubMed
    22. Zimmerman MA, Flores SC. Autoimmune-mediated oxidative stress and endothelial dysfunction: implications of accelerated vascular injury in type I diabetes. J Surg Res. 2009 Jul; 155(1):173-8.
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    23. Nicolls MR, Haskins K, Flores SC. Oxidant stress, immune dysregulation, and vascular function in type I diabetes. Antioxid Redox Signal. 2007 Jul; 9(7):879-89.
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    24. Tuder RM, Marecki JC, Richter A, Fijalkowska I, Flores S. Pathology of pulmonary hypertension. Clin Chest Med. 2007 Mar; 28(1):23-42, vii.
      View in: PubMed
    25. Marecki JC, Cool CD, Parr JE, Beckey VE, Luciw PA, Tarantal AF, Carville A, Shannon RP, Cota-Gomez A, Tuder RM, Voelkel NF, Flores SC. HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques. Am J Respir Crit Care Med. 2006 Aug 15; 174(4):437-45.
      View in: PubMed
    26. Marecki J, Cool C, Voelkel N, Luciw P, Flores S. Evidence for vascular remodeling in the lungs of macaques infected with simian immunodeficiency virus/HIV NEF recombinant virus. Chest. 2005 Dec; 128(6 Suppl):621S-622S.
      View in: PubMed
    27. Ling X, Cota-Gomez A, Flores NC, Hernandez-Saavedra D, McCord JM, Marecki JC, Haskins K, McDuffie M, Powers K, Kench J, Oka M, McMurtry I, Flores SC. Alterations in redox homeostasis and prostaglandins impair endothelial-dependent vasodilation in euglycemic autoimmune nonobese diabetic mice. Free Radic Biol Med. 2005 Oct 15; 39(8):1089-98.
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    28. Porntadavity S, Nath A, Prachayasittikul V, Cota-Gomez A, Flores SC, St Clair DK. Different roles of Sp family members in HIV-1 Tat-mediated manganese superoxide dismutase suppression in hepatocellular carcinoma cells. DNA Cell Biol. 2005 May; 24(5):299-310.
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    29. Hines IN, Harada H, Flores S, Gao B, McCord JM, Grisham MB. Endothelial nitric oxide synthase protects the post-ischemic liver: potential interactions with superoxide. Biomed Pharmacother. 2005 May; 59(4):183-9.
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    30. Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ, Aplin AE, Tai YT, Aguirre-Ghiso J, Flores SC, Melendez JA. Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem. 2005 Apr 29; 280(17):16916-24.
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    31. Stringer KA, Freed BM, Dunn JS, Sayers S, Gustafson DL, Flores SC. Particulate phase cigarette smoke increases MnSOD, NQO1, and CINC-1 in rat lungs. Free Radic Biol Med. 2004 Nov 15; 37(10):1527-33.
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    32. Marecki JC, Cota-Gomez A, Vaitaitis GM, Honda JR, Porntadavity S, St Clair DK, Flores SC. HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity. Free Radic Biol Med. 2004 Sep 15; 37(6):869-80.
      View in: PubMed
    33. Taniai H, Hines IN, Bharwani S, Maloney RE, Nimura Y, Gao B, Flores SC, McCord JM, Grisham MB, Aw TY. Susceptibility of murine periportal hepatocytes to hypoxia-reoxygenation: role for NO and Kupffer cell-derived oxidants. Hepatology. 2004 Jun; 39(6):1544-52.
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    34. Qadri I, Iwahashi M, Capasso JM, Hopken MW, Flores S, Schaack J, Simon FR. Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1. Biochem J. 2004 Mar 15; 378(Pt 3):919-28.
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    35. Harada H, Hines IN, Flores S, Gao B, McCord J, Scheerens H, Grisham MB. Role of NADPH oxidase-derived superoxide in reduced size liver ischemia and reperfusion injury. Arch Biochem Biophys. 2004 Mar 1; 423(1):103-8.
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    36. Bowers R, Cool C, Murphy RC, Tuder RM, Hopken MW, Flores SC, Voelkel NF. Oxidative stress in severe pulmonary hypertension. Am J Respir Crit Care Med. 2004 Mar 15; 169(6):764-9.
      View in: PubMed
    37. Haskins K, Bradley B, Powers K, Fadok V, Flores S, Ling X, Pugazhenthi S, Reusch J, Kench J. Oxidative stress in type 1 diabetes. Ann N Y Acad Sci. 2003 Nov; 1005:43-54.
      View in: PubMed
    38. Gu Y, Xu YC, Wu RF, Nwariaku FE, Souza RF, Flores SC, Terada LS. p47phox participates in activation of RelA in endothelial cells. J Biol Chem. 2003 May 9; 278(19):17210-7.
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    39. Tuder RM, Zhen L, Cho CY, Taraseviciene-Stewart L, Kasahara Y, Salvemini D, Voelkel NF, Flores SC. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):88-97.
      View in: PubMed
    40. Gao B, Flores SC, Leff JA, Bose SK, McCord JM. Synthesis and anti-inflammatory activity of a chimeric recombinant superoxide dismutase: SOD2/3. Am J Physiol Lung Cell Mol Physiol. 2003 Jun; 284(6):L917-25.
      View in: PubMed
    41. Hines IN, Hoffman JM, Scheerens H, Day BJ, Harada H, Pavlick KP, Bharwani S, Wolf R, Gao B, Flores S, McCord JM, Grisham MB. Regulation of postischemic liver injury following different durations of ischemia. Am J Physiol Gastrointest Liver Physiol. 2003 Mar; 284(3):G536-45.
      View in: PubMed
    42. Cota-Gomez A, Flores NC, Cruz C, Casullo A, Aw TY, Ichikawa H, Schaack J, Scheinman R, Flores SC. The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism. J Biol Chem. 2002 Apr 26; 277(17):14390-9.
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    43. Piganelli JD, Flores SC, Cruz C, Koepp J, Batinic-Haberle I, Crapo J, Day B, Kachadourian R, Young R, Bradley B, Haskins K. A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes. 2002 Feb; 51(2):347-55.
      View in: PubMed
    44. Kasahara Y, Tuder RM, Cool CD, Lynch DA, Flores SC, Voelkel NF. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med. 2001 Mar; 163(3 Pt 1):737-44.
      View in: PubMed
    45. Faust-Chan R, Hybertson B, Flores SC, Wright RM, Repine JE. Initiation and tolerance to acute lung injury: yin-yang mechanisms involving interleukin-1. Chest. 1999 Jul; 116(1 Suppl):102S-103S.
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    46. Gao B, Flores SC, Bose SK, McCord JM. A novel Escherichia coli vector for oxygen-inducible high level expression of foreign genes. Gene. 1996 Oct 17; 176(1-2):269-70.
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    47. Gao B, Flores SC, McCord JM. A site-directed mutant of Cu,Zn-superoxide dismutase modeled after native extracellular superoxide dismutase. Biol Trace Elem Res. 1995 Jan-Mar; 47(1-3):95-100.
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    48. McCord JM, Gao B, Leff J, Flores SC. Neutrophil-generated free radicals: possible mechanisms of injury in adult respiratory distress syndrome. Environ Health Perspect. 1994 Dec; 102 Suppl 10:57-60.
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    49. Flores SC, Marecki JC, Harper KP, Bose SK, Nelson SK, McCord JM. Tat protein of human immunodeficiency virus type 1 represses expression of manganese superoxide dismutase in HeLa cells. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7632-6.
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    50. Omar BA, Flores SC, McCord JM. Superoxide dismutase: pharmacological developments and applications. Adv Pharmacol. 1992; 23:109-61.
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    51. Gaubatz JW, Flores SC. Purification of eucaryotic extrachromosomal circular DNAs using exonuclease III. Anal Biochem. 1990 Feb 1; 184(2):305-10.
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    52. Gaubatz JW, Flores SC. Tissue-specific and age-related variations in repetitive sequences of mouse extrachromosomal circular DNAs. Mutat Res. 1990 Jan; 237(1):29-36.
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    53. Flores SC, Sunnerhagen P, Moore TK, Gaubatz JW. Characterization of repetitive sequence families in mouse heart small polydisperse circular DNAs: age-related studies. Nucleic Acids Res. 1988 May 11; 16(9):3889-906.
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    54. Flores SC, Moore TK, Gaubatz JW. Dispersed repetitive sequences of the mouse genome are differentially represented in extrachromosomal circular DNAs in vivo. Plasmid. 1987 May; 17(3):257-60.
      View in: PubMed
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