Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Charles Louis Edelstein

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-4810

    Collapse Research 
    Collapse research activities and funding
    R01DK056851     (EDELSTEIN, CHARLES LOUIS)Dec 1, 1999 - Mar 31, 2012
    NIH/NIDDK
    Caspase-1 signaling in ischemic acute renal failure
    Role: Principal Investigator

    R01DK074835     (EDELSTEIN, CHARLES LOUIS)Sep 15, 2007 - Aug 31, 2013
    NIH/NIDDK
    Mammalian target of rapamycin (mTOR) signaling in polycystic kidney disease (PKD)
    Role: Principal Investigator

    I01BX001737     (EDELSTEIN, CHARLES LOUIS)Jan 1, 2013 - Dec 31, 2016
    VA
    The IL-33/CD4 T cell/CXCL1 System in Acute Kidney Injury
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ. Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 Aug 15; 194(4):439-49. PMID: 26926297.
      View in: PubMed
    2. Gist KM, Kaufman J, da Cruz EM, Friesen RH, Crumback SL, Linders M, Edelstein C, Altmann C, Palmer C, Jalal D, Faubel S. A Decline in Intraoperative Renal Near-Infrared Spectroscopy Is Associated With Adverse Outcomes in Children Following Cardiac Surgery. Pediatr Crit Care Med. 2016 Apr; 17(4):342-9. PMID: 26914625.
      View in: PubMed
    3. Jain S, Keys D, Martin S, Edelstein CL, Jani A. Protection From Apoptotic Cell Death During Cold Storage Followed by Rewarming in 13-Lined Ground Squirrel Tubular Cells: The Role of Prosurvival Factors X-Linked Inhibitor of Apoptosis and PhosphoAkt. Transplantation. 2016 Mar; 100(3):538-45. PMID: 26457601.
      View in: PubMed
    4. Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z, Ljubanovic D, Weiser-Evans MC, Nemenoff RA, Edelstein CL. CD4 T cell knockout does not protect against kidney injury and worsens cancer. J Mol Med (Berl). 2016 Apr; 94(4):443-55. PMID: 26620676.
      View in: PubMed
    5. Ozkok A, Ravichandran K, Wang Q, Ljubanovic D, Edelstein CL. NF-?B transcriptional inhibition ameliorates cisplatin-induced acute kidney injury (AKI). Toxicol Lett. 2016 Jan 05; 240(1):105-13. PMID: 26546572.
      View in: PubMed
    6. Jain S, Keys D, Ljubanovic D, Edelstein CL, Jani A. Protection Against Cold Storage-Induced Renal Tubular Cell Apoptosis. Transplantation. 2015 Nov; 99(11):2311-6. PMID: 26177086.
      View in: PubMed
    7. Faubel S, Edelstein CL. Mechanisms and mediators of lung injury after acute kidney injury. Nat Rev Nephrol. 2016 Jan; 12(1):48-60. PMID: 26434402.
      View in: PubMed
    8. Hladinova Z, Hruskova Z, Svobodova B, Malickova K, Lanska V, Konopásek P, Jancova E, Rysava R, Edelstein CL, Tesar V. Increased levels of soluble ST2 in patients with active newly diagnosed ANCA-associated vasculitis. Mediators Inflamm. 2015; 2015:603750. PMID: 25802482.
      View in: PubMed
    9. Ravichandran K, Ozkok A, Wang Q, Mullick AE, Edelstein CL. Antisense-mediated angiotensinogen inhibition slows polycystic kidney disease in mice with a targeted mutation in Pkd2. Am J Physiol Renal Physiol. 2015 Feb 15; 308(4):F349-57. PMID: 25537744.
      View in: PubMed
    10. Jain S, Keys D, Nydam T, Plenter RJ, Edelstein CL, Jani A. Inhibition of autophagy increases apoptosis during re-warming after cold storage in renal tubular epithelial cells. Transpl Int. 2015 Feb; 28(2):214-23. PMID: 25270002.
      View in: PubMed
    11. Lee DW, Faubel S, Edelstein CL. A pan caspase inhibitor decreases caspase-1, IL-1a and IL-1ß, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules. Ren Fail. 2015 Feb; 37(1):144-50. PMID: 25310769.
      View in: PubMed
    12. Ravichandran K, Zafar I, Ozkok A, Edelstein CL. An mTOR kinase inhibitor slows disease progression in a rat model of polycystic kidney disease. Nephrol Dial Transplant. 2015 Jan; 30(1):45-53. PMID: 25239638.
      View in: PubMed
    13. Ozkok A, Edelstein CL. Pathophysiology of cisplatin-induced acute kidney injury. Biomed Res Int. 2014; 2014:967826. PMID: 25165721.
      View in: PubMed
    14. Ravichandran K, Zafar I, He Z, Doctor RB, Moldovan R, Mullick AE, Edelstein CL. An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2. Hum Mol Genet. 2014 Sep 15; 23(18):4919-31. PMID: 24847003.
      View in: PubMed
    15. Kim HJ, Ravichandran K, Ozkok A, Wang Q, He Z, Jani A, Ljubanovic D, Douglas IS, Edelstein CL. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun; 349(3):518-25. PMID: 24727856.
      View in: PubMed
    16. Ravichandran K, Edelstein CL. Polycystic kidney disease: a case of suppressed autophagy? Semin Nephrol. 2014 Jan; 34(1):27-33. PMID: 24485027.
      View in: PubMed
    17. Jani A, Martin SL, Jain S, Keys D, Edelstein CL. Renal adaptation during hibernation. Am J Physiol Renal Physiol. 2013 Dec 01; 305(11):F1521-32. PMID: 24049148.
      View in: PubMed
    18. Klawitter J, Zafar I, Klawitter J, Pennington AT, Klepacki J, Gitomer BY, Schrier RW, Christians U, Edelstein CL. Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease. BMC Nephrol. 2013 Jul 31; 14:165. PMID: 23902712.
      View in: PubMed
    19. Kim HJ, Lee DW, Ravichandran K, O Keys D, Akcay A, Nguyen Q, He Z, Jani A, Ljubanovic D, Edelstein CL. NLRP3 inflammasome knockout mice are protected against ischemic but not cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2013 Sep; 346(3):465-72. PMID: 23833276.
      View in: PubMed
    20. Keys DO, Edelstein CL. High-potency statins are associated with increased hospitalisations with acute kidney injury. Evid Based Med. 2014 Feb; 19(1):28. PMID: 23708201.
      View in: PubMed
    21. Parikh CR, Thiessen-Philbrook H, Garg AX, Kadiyala D, Shlipak MG, Koyner JL, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Coca SG. Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. Clin J Am Soc Nephrol. 2013 Jul; 8(7):1079-88. PMID: 23599408.
      View in: PubMed
    22. Sirota JC, Walcher A, Faubel S, Jani A, McFann K, Devarajan P, Davis CL, Edelstein CL. Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation. BMC Nephrol. 2013 Jan 17; 14:17. PMID: 23327592.
      View in: PubMed
    23. Koyner JL, Garg AX, Shlipak MG, Patel UD, Sint K, Hong K, Devarajan P, Edelstein CL, Zappitelli M, Thiessen-Philbrook H, Parikh CR. Urinary cystatin C and acute kidney injury after cardiac surgery. Am J Kidney Dis. 2013 May; 61(5):730-8. PMID: 23332602.
      View in: PubMed
    24. Klawitter J, Klawitter J, Schmitz V, Brunner N, Crunk A, Corby K, Bendrick-Peart J, Leibfritz D, Edelstein CL, Thurman JM, Christians U. Low-salt diet and cyclosporine nephrotoxicity: changes in kidney cell metabolism. J Proteome Res. 2012 Nov 02; 11(11):5135-44. PMID: 23057591.
      View in: PubMed
    25. Kim HJ, Edelstein CL. Mammalian target of rapamycin inhibition in polycystic kidney disease: From bench to bedside. Kidney Res Clin Pract. 2012 Sep; 31(3):132-8. PMID: 26894018.
      View in: PubMed
    26. Spahillari A, Parikh CR, Sint K, Koyner JL, Patel UD, Edelstein CL, Passik CS, Thiessen-Philbrook H, Swaminathan M, Shlipak MG. Serum cystatin C- versus creatinine-based definitions of acute kidney injury following cardiac surgery: a prospective cohort study. Am J Kidney Dis. 2012 Dec; 60(6):922-9. PMID: 22809763.
      View in: PubMed
    27. Ahuja N, Andres-Hernando A, Altmann C, Bhargava R, Bacalja J, Webb RG, He Z, Edelstein CL, Faubel S. Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice. Am J Physiol Renal Physiol. 2012 Sep 15; 303(6):F864-72. PMID: 22791336.
      View in: PubMed
    28. Nejat M, Pickering JW, Devarajan P, Bonventre JV, Edelstein CL, Walker RJ, Endre ZH. Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney Int. 2012 Jun; 81(12):1254-62. PMID: 22418979.
      View in: PubMed
    29. Lu L, Faubel S, He Z, Andres Hernando A, Jani A, Kedl R, Edelstein CL. Depletion of macrophages and dendritic cells in ischemic acute kidney injury. Am J Nephrol. 2012; 35(2):181-90. PMID: 22286667.
      View in: PubMed
    30. Parikh CR, Dahl NK, Chapman AB, Bost JE, Edelstein CL, Comer DM, Zeltner R, Tian X, Grantham JJ, Somlo S. Evaluation of urine biomarkers of kidney injury in polycystic kidney disease. Kidney Int. 2012 Apr; 81(8):784-90. PMID: 22258321.
      View in: PubMed
    31. Jani A, Epperson E, Martin J, Pacic A, Ljubanovic D, Martin SL, Edelstein CL. Renal protection from prolonged cold ischemia and warm reperfusion in hibernating squirrels. Transplantation. 2011 Dec 15; 92(11):1215-21. PMID: 22082817.
      View in: PubMed
    32. Altmann C, Andres-Hernando A, McMahan RH, Ahuja N, He Z, Rivard CJ, Edelstein CL, Barthel L, Janssen WJ, Faubel S. Macrophages mediate lung inflammation in a mouse model of ischemic acute kidney injury. Am J Physiol Renal Physiol. 2012 Feb 15; 302(4):F421-32. PMID: 22114207.
      View in: PubMed
    33. Ralib AM, Pickering JW, Shaw GM, Devarajan P, Edelstein CL, Bonventre JV, Endre ZH. Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. J Am Soc Nephrol. 2012 Feb; 23(2):322-33. PMID: 22095948.
      View in: PubMed
    34. Faubel S, Edelstein CL. Acute kidney injury: Severity of illness scoring systems in acute kidney injury. Nat Rev Nephrol. 2011 Nov 01; 8(1):8-10. PMID: 22045237.
      View in: PubMed
    35. Sirota JC, Klawitter J, Edelstein CL. Biomarkers of acute kidney injury. J Toxicol. 2011; 2011:328120. PMID: 22131986.
      View in: PubMed
    36. Akcay A, Nguyen Q, He Z, Turkmen K, Won Lee D, Hernando AA, Altmann C, Toker A, Pacic A, Ljubanovic DG, Jani A, Faubel S, Edelstein CL. IL-33 exacerbates acute kidney injury. J Am Soc Nephrol. 2011 Nov; 22(11):2057-67. PMID: 21949094.
      View in: PubMed
    37. Lee DW, Faubel S, Edelstein CL. Cytokines in acute kidney injury (AKI). Clin Nephrol. 2011 Sep; 76(3):165-73. PMID: 21888852.
      View in: PubMed
    38. Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim RW, Koyner JL, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD. Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephrol. 2011 Sep; 22(9):1737-47. PMID: 21836147.
      View in: PubMed
    39. Parikh CR, Coca SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Wang Z, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Swaminathan M, Garg AX. Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J Am Soc Nephrol. 2011 Sep; 22(9):1748-57. PMID: 21836143.
      View in: PubMed
    40. Turkmen K, Martin J, Akcay A, Nguyen Q, Ravichandran K, Faubel S, Pacic A, Ljubanovic D, Edelstein CL, Jani A. Apoptosis and autophagy in cold preservation ischemia. Transplantation. 2011 Jun 15; 91(11):1192-7. PMID: 21577181.
      View in: PubMed
    41. Nejat M, Hill JV, Pickering JW, Edelstein CL, Devarajan P, Endre ZH. Albuminuria increases cystatin C excretion: implications for urinary biomarkers. Nephrol Dial Transplant. 2012 Oct; 27 Suppl 3:iii96-103. PMID: 21551085.
      View in: PubMed
    42. Belcher JM, Edelstein CL, Parikh CR. Clinical applications of biomarkers for acute kidney injury. Am J Kidney Dis. 2011 Jun; 57(6):930-40. PMID: 21411200.
      View in: PubMed
    43. Endre ZH, Pickering JW, Walker RJ, Devarajan P, Edelstein CL, Bonventre JV, Frampton CM, Bennett MR, Ma Q, Sabbisetti VS, Vaidya VS, Walcher AM, Shaw GM, Henderson SJ, Nejat M, Schollum JB, George PM. Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int. 2011 May; 79(10):1119-30. PMID: 21307838.
      View in: PubMed
    44. Jani A, Zimmerman M, Martin J, Lu L, Turkmen K, Ravichandran K, Pacic A, Ljubanovic D, Edelstein CL. Perfusion storage reduces apoptosis in a porcine kidney model of donation after cardiac death. Transplantation. 2011 Jan 27; 91(2):169-75. PMID: 21200363.
      View in: PubMed
    45. Belibi F, Zafar I, Ravichandran K, Segvic AB, Jani A, Ljubanovic DG, Edelstein CL. Hypoxia-inducible factor-1a (HIF-1a) and autophagy in polycystic kidney disease (PKD). Am J Physiol Renal Physiol. 2011 May; 300(5):F1235-43. PMID: 21270095.
      View in: PubMed
    46. Dennen P, Altmann C, Kaufman J, Klein CL, Andres-Hernando A, Ahuja NH, Edelstein CL, Cadnapaphornchai MA, Keniston A, Faubel S. Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery. Crit Care. 2010; 14(5):R181. PMID: 20942931.
      View in: PubMed
    47. Belibi F, Ravichandran K, Zafar I, He Z, Edelstein CL. mTORC1/2 and rapamycin in female Han:SPRD rats with polycystic kidney disease. Am J Physiol Renal Physiol. 2011 Jan; 300(1):F236-44. PMID: 20943770.
      View in: PubMed
    48. Enomoto L, Anderson PL, Li S, Edelstein CL, Weinberg A. Effect of nucleoside and nucleotide analog reverse transcriptase inhibitors on cell-mediated immune functions. AIDS Res Hum Retroviruses. 2011 Jan; 27(1):47-55. PMID: 20929390.
      View in: PubMed
    49. Akcay A, Turkmen K, Lee D, Edelstein CL. Update on the diagnosis and management of acute kidney injury. Int J Nephrol Renovasc Dis. 2010; 3:129-40. PMID: 21694939.
      View in: PubMed
    50. Zafar I, Ravichandran K, Belibi FA, Doctor RB, Edelstein CL. Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease. Kidney Int. 2010 Oct; 78(8):754-61. PMID: 20686448.
      View in: PubMed
    51. Doctor RB, Serkova NJ, Hasebroock KM, Zafar I, Edelstein CL. Distinct patterns of kidney and liver cyst growth in pkd2(WS25/-) mice. Nephrol Dial Transplant. 2010 Nov; 25(11):3496-504. PMID: 20388629.
      View in: PubMed
    52. Belibi FA, Edelstein CL. Novel targets for the treatment of autosomal dominant polycystic kidney disease. Expert Opin Investig Drugs. 2010 Mar; 19(3):315-28. PMID: 20141351.
      View in: PubMed
    53. Akcay A, Nguyen Q, Edelstein CL. Mediators of inflammation in acute kidney injury. Mediators Inflamm. 2009; 2009:137072. PMID: 20182538.
      View in: PubMed
    54. Belibi FA, Edelstein CL. Metastatic Renal Cancer: What Role for Everolimus? Clin Med Rev Oncol. 2010 Feb 18; 2:4. PMID: 24771995.
      View in: PubMed
    55. Liu KD, Altmann C, Smits G, Krawczeski CD, Edelstein CL, Devarajan P, Faubel S. Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Crit Care. 2009; 13(4):R104. PMID: 19570208.
      View in: PubMed
    56. Zafar I, Belibi FA, He Z, Edelstein CL. Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD). Nephrol Dial Transplant. 2009 Aug; 24(8):2349-53. PMID: 19321761.
      View in: PubMed
    57. Jiménez C, Capasso JM, Edelstein CL, Rivard CJ, Lucia S, Breusegem S, Berl T, Segovia M. Different ways to die: cell death modes of the unicellular chlorophyte Dunaliella viridis exposed to various environmental stresses are mediated by the caspase-like activity DEVDase. J Exp Bot. 2009; 60(3):815-28. PMID: 19251986.
      View in: PubMed
    58. He Z, Dursun B, Oh DJ, Lu L, Faubel S, Edelstein CL. Macrophages are not the source of injurious interleukin-18 in ischemic acute kidney injury in mice. Am J Physiol Renal Physiol. 2009 Mar; 296(3):F535-42. PMID: 19129255.
      View in: PubMed
    59. Belibi FA, Edelstein CL. Unified ultrasonographic diagnostic criteria for polycystic kidney disease. J Am Soc Nephrol. 2009 Jan; 20(1):6-8. PMID: 19073819.
      View in: PubMed
    60. Yalavarthy R, Edelstein CL. Therapeutic and predictive targets of AKI. Clin Nephrol. 2008 Dec; 70(6):453-63. PMID: 19049701.
      View in: PubMed
    61. Yalavarthy R, Smith ML, Edelstein CL. HIV-associated nephropathy in Caucasians: case report and review of literature. Int J STD AIDS. 2008 Nov; 19(11):789-90. PMID: 18931278.
      View in: PubMed
    62. He Z, Lu L, Altmann C, Hoke TS, Ljubanovic D, Jani A, Dinarello CA, Faubel S, Edelstein CL. Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury. Am J Physiol Renal Physiol. 2008 Nov; 295(5):F1414-21. PMID: 18753296.
      View in: PubMed
    63. Edelstein CL. Biomarkers of acute kidney injury. Adv Chronic Kidney Dis. 2008 Jul; 15(3):222-34. PMID: 18565474.
      View in: PubMed
    64. Faubel S, Edelstein CL. Exciting times in research regarding the definition, diagnosis, complications, and outcomes of acute kidney injury. Adv Chronic Kidney Dis. 2008 Jul; 15(3):211-2. PMID: 18565472.
      View in: PubMed
    65. Edelstein CL. Mammalian target of rapamycin and caspase inhibitors in polycystic kidney disease. Clin J Am Soc Nephrol. 2008 Jul; 3(4):1219-26. PMID: 18587045.
      View in: PubMed
    66. Edelstein CL. Therapeutic interventions for autosomal dominant polycystic kidney disease. Nephrol News Issues. 2008 Mar; 22(3):25-6. PMID: 18372677.
      View in: PubMed
    67. Tao Y, Zafar I, Kim J, Schrier RW, Edelstein CL. Caspase-3 gene deletion prolongs survival in polycystic kidney disease. J Am Soc Nephrol. 2008 Apr; 19(4):749-55. PMID: 18272845.
      View in: PubMed
    68. Oh DJ, Dursun B, He Z, Lu L, Hoke TS, Ljubanovic D, Faubel S, Edelstein CL. Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Am J Physiol Renal Physiol. 2008 Jan; 294(1):F264-71. PMID: 18003857.
      View in: PubMed
    69. Parikh CR, Edelstein CL, Devarajan P, Cantley L. Biomarkers of acute kidney injury: early diagnosis, pathogenesis, and recovery. J Investig Med. 2007 Nov; 55(7):333-40. PMID: 18062893.
      View in: PubMed
    70. Lu LH, Oh DJ, Dursun B, He Z, Hoke TS, Faubel S, Edelstein CL. Increased macrophage infiltration and fractalkine expression in cisplatin-induced acute renal failure in mice. J Pharmacol Exp Ther. 2008 Jan; 324(1):111-7. PMID: 17932247.
      View in: PubMed
    71. Yalavarthy R, Smith ML, Edelstein C. Acute kidney injury complicating minimal change disease: the case for careful use of diuretics and angiotensin-converting enzyme inhibitors. Nephrology (Carlton). 2007 Oct; 12(5):529-31. PMID: 17803480.
      View in: PubMed
    72. Yalavarthy R, Edelstein CL, Teitelbaum I. Acute renal failure and chronic kidney disease following liver transplantation. Hemodial Int. 2007 Oct; 11 Suppl 3:S7-12. PMID: 17897111.
      View in: PubMed
    73. Washburn KK, Zappitelli M, Arikan AA, Loftis L, Yalavarthy R, Parikh CR, Edelstein CL, Goldstein SL. Urinary interleukin-18 is an acute kidney injury biomarker in critically ill children. Nephrol Dial Transplant. 2008 Feb; 23(2):566-72. PMID: 17911094.
      View in: PubMed
    74. Tao Y, Kim J, Yin Y, Zafar I, Falk S, He Z, Faubel S, Schrier RW, Edelstein CL. VEGF receptor inhibition slows the progression of polycystic kidney disease. Kidney Int. 2007 Dec; 72(11):1358-66. PMID: 17882148.
      View in: PubMed
    75. Zafar I, Tao Y, Falk S, McFann K, Schrier RW, Edelstein CL. Effect of statin and angiotensin-converting enzyme inhibition on structural and hemodynamic alterations in autosomal dominant polycystic kidney disease model. Am J Physiol Renal Physiol. 2007 Sep; 293(3):F854-9. PMID: 17581927.
      View in: PubMed
    76. Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, Oh DJ, Lu L, Klein CL, Dinarello CA, Edelstein CL. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther. 2007 Jul; 322(1):8-15. PMID: 17400889.
      View in: PubMed
    77. Edelstein CL, Hoke TS, Somerset H, Fang W, Klein CL, Dinarello CA, Faubel S. Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury. Nephrol Dial Transplant. 2007 Apr; 22(4):1052-61. PMID: 17255124.
      View in: PubMed
    78. Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S. Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007 Jan; 18(1):155-64. PMID: 17167117.
      View in: PubMed
    79. Parikh CR, Jani A, Mishra J, Ma Q, Kelly C, Barasch J, Edelstein CL, Devarajan P. Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J Transplant. 2006 Jul; 6(7):1639-45. PMID: 16827865.
      View in: PubMed
    80. Parikh CR, Mishra J, Thiessen-Philbrook H, Dursun B, Ma Q, Kelly C, Dent C, Devarajan P, Edelstein CL. Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery. Kidney Int. 2006 Jul; 70(1):199-203. PMID: 16710348.
      View in: PubMed
    81. Dursun B, He Z, Somerset H, Oh DJ, Faubel S, Edelstein CL. Caspases and calpain are independent mediators of cisplatin-induced endothelial cell necrosis. Am J Physiol Renal Physiol. 2006 Sep; 291(3):F578-87. PMID: 16622172.
      View in: PubMed
    82. Jani A, Wang W, Faubel S, Falk S, Ljubanovic D, Dursun B, Edelstein CL. Ischemic acute renal failure following nephrectomy impairs long-term renal function. Transplantation. 2006 Mar 15; 81(5):800-3. PMID: 16534486.
      View in: PubMed
    83. Thurman JM, Royer PA, Ljubanovic D, Dursun B, Lenderink AM, Edelstein CL, Holers VM. Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury. J Am Soc Nephrol. 2006 Mar; 17(3):707-15. PMID: 16467447.
      View in: PubMed
    84. Edelstein CL. What is the role of tubular epithelial cell apoptosis in polycystic kidney disease (PKD)? Cell Cycle. 2005 Nov; 4(11):1550-4. PMID: 16258272.
      View in: PubMed
    85. Faubel S, Ljubanovic D, Poole B, Dursun B, He Z, Cushing S, Somerset H, Gill RG, Edelstein CL. Peripheral CD4 T-cell depletion is not sufficient to prevent ischemic acute renal failure. Transplantation. 2005 Sep 15; 80(5):643-9. PMID: 16177639.
      View in: PubMed
    86. Parikh CR, Abraham E, Ancukiewicz M, Edelstein CL. Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol. 2005 Oct; 16(10):3046-52. PMID: 16148039.
      View in: PubMed
    87. Faubel S, Edelstein CL. Caspases as drug targets in ischemic organ injury. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Sep; 5(3):269-87. PMID: 16178788.
      View in: PubMed
    88. Gibney EM, Edelstein CL, Wiseman AC, Bak T. Page kidney causing reversible acute renal failure: an unusual complication of transplant biopsy. Transplantation. 2005 Jul 27; 80(2):285-6. PMID: 16041280.
      View in: PubMed
    89. Tao Y, Kim J, Faubel S, Wu JC, Falk SA, Schrier RW, Edelstein CL. Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6954-9. PMID: 15863619.
      View in: PubMed
    90. Dursun B, Edelstein CL. Acute renal failure. Am J Kidney Dis. 2005 Mar; 45(3):614-8. PMID: 15754287.
      View in: PubMed
    91. Tao Y, Kim J, Stanley M, He Z, Faubel S, Schrier RW, Edelstein CL. Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD). Kidney Int. 2005 Mar; 67(3):909-19. PMID: 15698430.
      View in: PubMed
    92. Wang W, Faubel S, Ljubanovic D, Mitra A, Falk SA, Kim J, Tao Y, Soloviev A, Reznikov LL, Dinarello CA, Schrier RW, Edelstein CL. Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice. Am J Physiol Renal Physiol. 2005 May; 288(5):F997-1004. PMID: 15644489.
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    93. Weinberg A, Jesser RD, Edelstein CL, Bill JR, Wohl DA. Excess apoptosis of mononuclear cells contributes to the depressed cytomegalovirus-specific immunity in HIV-infected patients on HAART. Virology. 2004 Dec 05; 330(1):313-21. PMID: 15527856.
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    94. Faubel S, Ljubanovic D, Reznikov L, Somerset H, Dinarello CA, Edelstein CL. Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis. Kidney Int. 2004 Dec; 66(6):2202-13. PMID: 15569309.
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    95. Tao Y, Kim J, Schrier RW, Edelstein CL. Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease. J Am Soc Nephrol. 2005 Jan; 16(1):46-51. PMID: 15563559.
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    96. Jani A, Ljubanovic D, Faubel S, Kim J, Mischak R, Edelstein CL. Caspase inhibition prevents the increase in caspase-3, -2, -8 and -9 activity and apoptosis in the cold ischemic mouse kidney. Am J Transplant. 2004 Aug; 4(8):1246-54. PMID: 15268725.
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    97. Parikh CR, Sandmaier BM, Storb RF, Blume KG, Sahebi F, Maloney DG, Maris MB, Nieto Y, Edelstein CL, Schrier RW, McSweeney P. Acute renal failure after nonmyeloablative hematopoietic cell transplantation. J Am Soc Nephrol. 2004 Jul; 15(7):1868-76. PMID: 15213275.
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    98. Parikh CR, Jani A, Melnikov VY, Faubel S, Edelstein CL. Urinary interleukin-18 is a marker of human acute tubular necrosis. Am J Kidney Dis. 2004 Mar; 43(3):405-14. PMID: 14981598.
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    99. Jiménez C, Berl T, Rivard CJ, Edelstein CL, Capasso JM. Phosphorylation of MAP kinase-like proteins mediate the response of the halotolerant alga Dunaliella viridis to hypertonic shock. Biochim Biophys Acta. 2004 Feb 02; 1644(1):61-9. PMID: 14741745.
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    100. Thurman JM, Ljubanovic D, Edelstein CL, Gilkeson GS, Holers VM. Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice. J Immunol. 2003 Feb 01; 170(3):1517-23. PMID: 12538716.
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    101. Melnikov VY, Faubel S, Siegmund B, Lucia MS, Ljubanovic D, Edelstein CL. Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice. J Clin Invest. 2002 Oct; 110(8):1083-91. PMID: 12393844.
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    102. Wang W, Falk SA, Jittikanont S, Gengaro PE, Edelstein CL, Schrier RW. Protective effect of renal denervation on normotensive endotoxemia-induced acute renal failure in mice. Am J Physiol Renal Physiol. 2002 Sep; 283(3):F583-7. PMID: 12167611.
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    103. Schrier R, McFann K, Johnson A, Chapman A, Edelstein C, Brosnahan G, Ecder T, Tison L. Cardiac and renal effects of standard versus rigorous blood pressure control in autosomal-dominant polycystic kidney disease: results of a seven-year prospective randomized study. J Am Soc Nephrol. 2002 Jul; 13(7):1733-9. PMID: 12089368.
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    104. Ecder T, Melnikov VY, Stanley M, Korular D, Lucia MS, Schrier RW, Edelstein CL. Caspases, Bcl-2 proteins and apoptosis in autosomal-dominant polycystic kidney disease. Kidney Int. 2002 Apr; 61(4):1220-30. PMID: 11918728.
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    105. Edelstein C, Nakajima K, Pfaffinger D, Scanu AM. Oxidative events cause degradation of apoB-100 but not of apo[a] and facilitate enzymatic cleavage of both proteins. J Lipid Res. 2001 Oct; 42(10):1664-70. PMID: 11590223.
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    106. Lelamali K, Wang W, Gengaro P, Edelstein C, Schrier RW. Effects of nitric oxide and peroxynitrite on endotoxin-induced leukocyte adhesion to endothelium. J Cell Physiol. 2001 Sep; 188(3):337-42. PMID: 11473360.
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    107. Abdallah JG, Schrier RW, Edelstein C, Jennings SD, Wyse B, Ellison DH. Loop diuretic infusion increases thiazide-sensitive Na(+)/Cl(-)-cotransporter abundance: role of aldosterone. J Am Soc Nephrol. 2001 Jul; 12(7):1335-41. PMID: 11423562.
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    108. Knotek M, Rogachev B, Wang W, Ecder T, Melnikov V, Gengaro PE, Esson M, Edelstein CL, Dinarello CA, Schrier RW. Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int. 2001 Jun; 59(6):2243-9. PMID: 11380827.
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    109. Melnikov VY, Ecder T, Fantuzzi G, Siegmund B, Lucia MS, Dinarello CA, Schrier RW, Edelstein CL. Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure. J Clin Invest. 2001 May; 107(9):1145-52. PMID: 11342578.
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    110. Wangsiripaisan A, Gengaro PE, Edelstein CL, Schrier RW. Role of polymeric Tamm-Horsfall protein in cast formation: oligosaccharide and tubular fluid ions. Kidney Int. 2001 Mar; 59(3):932-40. PMID: 11231348.
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    111. Ecder T, Edelstein CL, Fick-Brosnahan GM, Johnson AM, Chapman AB, Gabow PA, Schrier RW. Diuretics versus angiotensin-converting enzyme inhibitors in autosomal dominant polycystic kidney disease. Am J Nephrol. 2001 Mar-Apr; 21(2):98-103. PMID: 11359016.
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    112. DeBiasi RL, Edelstein CL, Sherry B, Tyler KL. Calpain inhibition protects against virus-induced apoptotic myocardial injury. J Virol. 2001 Jan; 75(1):351-61. PMID: 11119604.
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    113. Knotek M, Esson M, Gengaro P, Edelstein CL, Schrier RW. Desensitization of soluble guanylate cyclase in renal cortex during endotoxemia in mice. J Am Soc Nephrol. 2000 Nov; 11(11):2133-7. PMID: 11053491.
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    114. Shi Y, Melnikov VY, Schrier RW, Edelstein CL. Downregulation of the calpain inhibitor protein calpastatin by caspases during renal ischemia-reperfusion. Am J Physiol Renal Physiol. 2000 Sep; 279(3):F509-17. PMID: 10966930.
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    115. Ecder T, Edelstein CL, Fick-Brosnahan GM, Johnson AM, Duley IT, Gabow PA, Schrier RW. Progress in blood pressure control in autosomal dominant polycystic kidney disease. Am J Kidney Dis. 2000 Aug; 36(2):266-71. PMID: 10922304.
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    116. Ecder T, Chapman AB, Brosnahan GM, Edelstein CL, Johnson AM, Schrier RW. Effect of antihypertensive therapy on renal function and urinary albumin excretion in hypertensive patients with autosomal dominant polycystic kidney disease. Am J Kidney Dis. 2000 Mar; 35(3):427-32. PMID: 10692268.
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    117. Edelstein CL. Calcium-mediated proximal tubular injury-what is the role of cysteine proteases? Nephrol Dial Transplant. 2000 Feb; 15(2):141-4. PMID: 10648654.
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    118. Edelstein CL. Calpain activity in rat renal proximal tubules. An in vitro assay. Methods Mol Biol. 2000; 144:233-8. PMID: 10818768.
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    119. Edelstein CL. Calpain activity in rat renal proximal tubules. An in situ assay. Methods Mol Biol. 2000; 144:239-43. PMID: 10818769.
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    120. Edelstein CL. Rat renal proximal tubules, hypoxia, ionomycin, and calpain. Methods Mol Biol. 2000; 144:225-32. PMID: 10818767.
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    121. Edelstein CL, Shi Y, Schrier RW. Role of caspases in hypoxia-induced necrosis of rat renal proximal tubules. J Am Soc Nephrol. 1999 Sep; 10(9):1940-9. PMID: 10477146.
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    122. Ling H, Edelstein C, Gengaro P, Meng X, Lucia S, Knotek M, Wangsiripaisan A, Shi Y, Schrier R. Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase knockout mice. Am J Physiol. 1999 Sep; 277(3 Pt 2):F383-90. PMID: 10484522.
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    123. Kribben A, Edelstein CL, Schrier RW. Pathophysiology of acute renal failure. J Nephrol. 1999 Jul-Aug; 12 Suppl 2:S142-51. PMID: 10688414.
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    124. Wangsiripaisan A, Gengaro PE, Nemenoff RA, Ling H, Edelstein CL, Schrier RW. Effect of nitric oxide donors on renal tubular epithelial cell-matrix adhesion. Kidney Int. 1999 Jun; 55(6):2281-8. PMID: 10354276.
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    125. Ecder T, Edelstein CL, Chapman AB, Johnson AM, Tison L, Gill EA, Brosnahan GM, Schrier RW. Reversal of left ventricular hypertrophy with angiotensin converting enzyme inhibition in hypertensive patients with autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 1999 May; 14(5):1113-6. PMID: 10344347.
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    126. Edelstein C, Shapiro SD, Klezovitch O, Scanu AM. Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology. J Biol Chem. 1999 Apr 09; 274(15):10019-23. PMID: 10187779.
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    127. Fless GM, Kirk EW, Klezovitch O, Santiago JY, Edelstein C, Hoover-Plow J, Scanu AM. Effect of phospholipase A2 digestion on the conformation and lysine/fibrinogen binding properties of human lipoprotein[a]. J Lipid Res. 1999 Apr; 40(4):583-92. PMID: 10191282.
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    128. Ling H, Gengaro PE, Edelstein CL, Martin PY, Wangsiripaisan A, Nemenoff R, Schrier RW. Effect of hypoxia on proximal tubules isolated from nitric oxide synthase knockout mice. Kidney Int. 1998 Jun; 53(6):1642-6. PMID: 9607195.
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    129. Shields CL, Shields JA, Cater J, Lois N, Edelstein C, Gündüz K, Mercado G. Transpupillary thermotherapy for choroidal melanoma: tumor control and visual results in 100 consecutive cases. Ophthalmology. 1998 Apr; 105(4):581-90. PMID: 9544628.
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    130. Edelstein CL, Ling H, Gengaro PE, Nemenoff RA, Bahr BA, Schrier RW. Effect of glycine on prelethal and postlethal increases in calpain activity in rat renal proximal tubules. Kidney Int. 1997 Nov; 52(5):1271-8. PMID: 9350650.
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    131. Edelstein CL, Ling H, Wangsiripaisan A, Schrier RW. Emerging therapies for acute renal failure. Am J Kidney Dis. 1997 Nov; 30(5 Suppl 4):S89-95. PMID: 9372985.
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    132. Edelstein CL, Ling H, Schrier RW. The nature of renal cell injury. Kidney Int. 1997 May; 51(5):1341-51. PMID: 9150442.
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    133. Edelstein C, Italia JA, Scanu AM. Polymorphonuclear cells isolated from human peripheral blood cleave lipoprotein(a) and apolipoprotein(a) at multiple interkringle sites via the enzyme elastase. Generation of mini-Lp(a) particles and apo(a) fragments. J Biol Chem. 1997 Apr 25; 272(17):11079-87. PMID: 9111002.
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    134. Edelstein CL, Alkhunaizi AA, Schrier RW. The role of calcium in the pathogenesis of acute renal failure. Ren Fail. 1997 Mar; 19(2):199-207. PMID: 9101591.
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    135. Edelstein CL, Yaqoob MM, Alkhunaizi AM, Gengaro PE, Nemenoff RA, Wang KK, Schrier RW. Modulation of hypoxia-induced calpain activity in rat renal proximal tubules. Kidney Int. 1996 Oct; 50(4):1150-7. PMID: 8887272.
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    136. Yaqoob M, Edelstein CL, Schrier RW. Role of nitric oxide and superoxide balance in hypoxia-reoxygenation proximal tubular injury. Nephrol Dial Transplant. 1996 Sep; 11(9):1743-6. PMID: 8918615.
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    137. Yaqoob M, Edelstein CL, Schrier RW. Role of nitric oxide and superoxide balance in hypoxia-reoxygenation proximal tubular injury. Nephrol Dial Transplant. 1996 Sep; 11(9):1738-42. PMID: 9011842.
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    138. Edelstein C, Italia JA, Klezovitch O, Scanu AM. Functional and metabolic differences between elastase-generated fragments of human lipoprotein[a] and apolipoprotein[a]. J Lipid Res. 1996 Aug; 37(8):1786-801. PMID: 8864963.
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    139. Klezovitch O, Edelstein C, Scanu AM. Evidence that the fibrinogen binding domain of Apo(a) is outside the lysine binding site of kringle IV-10: a study involving naturally occurring lysine binding defective lipoprotein(a) phenotypes. J Clin Invest. 1996 Jul 01; 98(1):185-91. PMID: 8690792.
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    140. Edelstein CL, Yaqoob MM, Schrier RW. The role of the calcium-dependent enzymes nitric oxide synthase and calpain in hypoxia-induced proximal tubule injury. Ren Fail. 1996 May; 18(3):501-11. PMID: 8827996.
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    141. Yaqoob M, Edelstein CL, Wieder ED, Alkhunaizi AM, Gengaro PE, Nemenoff RA, Schrier RW. Nitric oxide kinetics during hypoxia in proximal tubules: effects of acidosis and glycine. Kidney Int. 1996 May; 49(5):1314-9. PMID: 8731096.
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    142. Alkhunaizi AM, Yaqoob MM, Edelstein CL, Gengaro PE, Burke TJ, Nemenoff RA, Schrier RW. Arachidonic acid protects against hypoxic injury in rat proximal tubules. Kidney Int. 1996 Mar; 49(3):620-5. PMID: 8648901.
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    143. Choi KH, Edelstein CL, Gengaro P, Schrier RW, Nemenoff RA. Hypoxia induces changes in phospholipase A2 in rat proximal tubules: evidence for multiple forms. Am J Physiol. 1995 Dec; 269(6 Pt 2):F846-53. PMID: 8594879.
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    144. Edelstein CL, Wieder ED, Yaqoob MM, Gengaro PE, Burke TJ, Nemenoff RA, Schrier RW. The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7662-6. PMID: 7644473.
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    145. Edelstein CL, Bates WD. Subtypes of acute postinfectious glomerulonephritis: a clinico-pathological correlation. Clin Nephrol. 1992 Dec; 38(6):311-7. PMID: 1468161.
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    146. Gordon JI, Sims HF, Edelstein C, Scanu AM, Strauss AW. Extracellular processing of proapolipoprotein A-II in Hep G2 cell cultures is mediated by a 54-kDa protease immunologically related to cathepsin B. J Biol Chem. 1985 Nov 25; 260(27):14824-31. PMID: 2414299.
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    147. Gordon JI, Sims HF, Edelstein C, Scanu AM, Strauss AW. Human proapolipoprotein A-II is cleaved following secretion from Hep G2 cells by a thiol protease. J Biol Chem. 1984 Dec 25; 259(24):15556-63. PMID: 6096378.
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    148. Edelstein C, Gordon JI, Vergani CA, Catapano AL, Pietrini V, Scanu AM. Comparative in vitro study of the pro-apolipoprotein A-I to apolipoprotein A-I converting activity between normal and Tangier plasma. J Clin Invest. 1984 Sep; 74(3):1098-103. PMID: 6432845.
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    149. Scanu A, Toth J, Edelstein C, Koga S, Stiller E. Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneity. Biochemistry. 1969 Aug; 8(8):3309-16. PMID: 4980192.
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