 Clusterin
"Clusterin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly conserved heterodimeric glycoprotein that is differentially expressed during many severe physiological disturbance states such as CANCER; APOPTOSIS; and various NEUROLOGICAL DISORDERS. Clusterin is ubiquitously expressed and appears to function as a secreted MOLECULAR CHAPERONE.
| Descriptor ID |
D051152
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| MeSH Number(s) |
D12.776.395.207 D12.776.580.215
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| Concept/Terms |
Clusterin- Clusterin
- SGP-2 Protein
- SGP 2 Protein
- Apolipoprotein J
- Complement Lysis Inhibitor
- Complement-Associated Protein SP-40,40
- Complement Associated Protein SP 40,40
- SP-40,40, Complement-Associated Protein
- Sulfated Glycoprotein 2
- Sulfated Glycoprotein-2
- Ionizing Radiation-Induced Protein-8
- Ionizing Radiation Induced Protein 8
- Radiation-Induced Protein-8, Ionizing
- XIP8 Protein
- X-Ray-Inducible Protein 8
- X Ray Inducible Protein 8
- Testosterone-Repressed Prostate Message-2 Protein
- Testosterone Repressed Prostate Message 2 Protein
- ApoJ Protein
- TRPM-2 Protein
- TRPM 2 Protein
- MAC393 Antigen
- SP 40,40 Protein
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Below are MeSH descriptors whose meaning is more general than "Clusterin".
Below are MeSH descriptors whose meaning is more specific than "Clusterin".
This graph shows the total number of publications written about "Clusterin" by people in this website by year, and whether "Clusterin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Clusterin" by people in Profiles.
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Spatharas PM, Nasi GI, Tsiolaki PL, Theodoropoulou MK, Papandreou NC, Hoenger A, Trougakos IP, Iconomidou VA. Clusterin in Alzheimer's disease: An amyloidogenic inhibitor of amyloid formation? Biochim Biophys Acta Mol Basis Dis. 2022 07 01; 1868(7):166384.
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Griffin BR, Faubel S, Edelstein CL. Biomarkers of Drug-Induced Kidney Toxicity. Ther Drug Monit. 2019 04; 41(2):213-226.
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Harrison TM, Mahmood Z, Lau EP, Karacozoff AM, Burggren AC, Small GW, Bookheimer SY. An Alzheimer's Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults. eNeuro. 2016 May-Jun; 3(3).
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Greene MJ, Klimtchuk ES, Seldin DC, Berk JL, Connors LH. Cooperative stabilization of transthyretin by clusterin and diflunisal. Biochemistry. 2015 Jan 20; 54(2):268-78.
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Rove KO, Crawford ED. Evolution of treatment options for patients with CRPC and bone metastases: bone-targeted agents that go beyond palliation of symptoms to improve overall survival. Oncology (Williston Park). 2011 Dec; 25(14):1362-70, 1375-81, 1387.
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Greene MJ, Sam F, Soo Hoo PT, Patel RS, Seldin DC, Connors LH. Evidence for a functional role of the molecular chaperone clusterin in amyloidotic cardiomyopathy. Am J Pathol. 2011 Jan; 178(1):61-8.
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Gibson JH, Slobedman B, K N H, Williamson SL, Minchenko D, El-Osta A, Stern JL, Christodoulou J. Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain. BMC Neurosci. 2010 Apr 26; 11:53.
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Kliger Y, Levy O, Oren A, Ashkenazy H, Tiran Z, Novik A, Rosenberg A, Amir A, Wool A, Toporik A, Schreiber E, Eshel D, Levine Z, Cohen Y, Nold-Petry C, Dinarello CA, Borukhov I. Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):13797-801.
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Kondoh G, Yomogida K, Dohmae K, Nozawa M, Koga M, Nonomura N, Miki T, Okuyama A, Nishimune Y. Coexpression of multiple Sertoli cell and Leydig cell marker genes in the spontaneous testicular tumor of F344 rat: evidence for phenotypical bifurcation of the interstitial cell tumor. Jpn J Cancer Res. 1997 Sep; 88(9):839-45.
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Wada K, Nomura S, Morii E, Kitamura Y, Nishizawa Y, Miyake A, Terada N. Changes in levels of mRNAs of transforming growth factor (TGF)-beta1, -beta2, -beta3, TGF-beta type II receptor and sulfated glycoprotein-2 during apoptosis of mouse uterine epithelium. J Steroid Biochem Mol Biol. 1996 Dec; 59(5-6):367-75.
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