 Immunoglobulins
"Immunoglobulins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
| Descriptor ID |
D007136
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| MeSH Number(s) |
D12.776.124.486.485 D12.776.124.790.651 D12.776.377.715.548
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| Concept/Terms |
Immunoglobulins- Immunoglobulins
- Immunoglobulin
- Globulins, Immune
- Immune Globulins
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulins".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulins".
This graph shows the total number of publications written about "Immunoglobulins" by people in this website by year, and whether "Immunoglobulins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 0 | 2 | | 1995 | 1 | 0 | 1 | | 1996 | 1 | 2 | 3 | | 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 2 | 1 | 3 | | 2000 | 2 | 2 | 4 | | 2001 | 3 | 0 | 3 | | 2002 | 2 | 4 | 6 | | 2003 | 2 | 1 | 3 | | 2004 | 0 | 2 | 2 | | 2005 | 3 | 2 | 5 | | 2006 | 0 | 2 | 2 | | 2007 | 1 | 2 | 3 | | 2008 | 1 | 2 | 3 | | 2009 | 0 | 5 | 5 | | 2010 | 3 | 0 | 3 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 3 | 3 | | 2013 | 1 | 0 | 1 | | 2014 | 2 | 3 | 5 | | 2015 | 3 | 2 | 5 | | 2016 | 1 | 2 | 3 | | 2017 | 0 | 2 | 2 | | 2018 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 1 | 2 | | 2022 | 0 | 2 | 2 | | 2023 | 0 | 3 | 3 |
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Below are the most recent publications written about "Immunoglobulins" by people in Profiles.
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Hughes BL, Clifton RG, Rouse DJ, Saade GR, Dinsmoor MJ, Reddy UM, Pass R, Allard D, Mallett G, MacPherson C, Wapner R, Metz T, Goodnight WH, Tita ATN, Costantine MM, Swamy GK, Heyborne KD, Chien EK, Chauhan SP, El-Sayed YY, Casey BM, Parry S, Simhan HN, Napolitano PG, Macones GA. Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection - 2-Year Outcomes. N Engl J Med. 2023 Nov 09; 389(19):1822-1824.
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Pillsbury CE, Dougan J, Rabe JL, Fonseca JA, Zhou C, Evans AN, Abukharma H, Ichoku O, Gonzalez-Flamenco G, Park SI, Aljudi A, DeRyckere D, Castellino SM, Rafiq S, Langermann S, Liu LN, Henry CJ, Porter CC. Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia. Cancer Res Commun. 2023 07; 3(7):1248-1259.
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Palmer WH, Leaton LA, Campos Codo A, Crute B, Roest J, Zhu S, Petersen J, Tobin RP, Hume PS, Stone M, van Bokhoven A, Gerich ME, McCarter MD, Zhu Y, Janssen WJ, Vivian JP, Trowsdale J, Getahun A, Rossjohn J, Cambier J, Loh L, Norman PJ. Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells. Sci Immunol. 2023 Jun 30; 8(84):eade5343.
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Wang LA, Abbott JK. "Common variable immunodeficiency: Challenges for diagnosis". J Immunol Methods. 2022 10; 509:113342.
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Pereira MJ, Wager B, Garrigues RJ, Gerlach E, Quinn JD, Dowdell AS, Osburne MS, Z?ckert WR, Kraiczy P, Garcia BL, Leong JM. Lipoproteome screening of the Lyme disease agent identifies inhibitors of antibody-mediated complement killing. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2117770119.
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Schweitzer KS, Jinawath N, Yonescu R, Ni K, Rush N, Charoensawan V, Bronova I, Berdyshev E, Leach SM, Gillenwater LA, Bowler RP, Pearse DB, Griffin CA, Petrache I. IGSF3 mutation identified in patient with severe COPD alters cell function and motility. JCI Insight. 2020 07 23; 5(14).
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Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR. Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239.
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Mensah KA, Chen JW, Schickel JN, Isnardi I, Yamakawa N, Vega-Loza A, Anolik JH, Gatti RA, Gelfand EW, Montgomery RR, Horowitz MC, Craft JE, Meffre E. Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis. Sci Transl Med. 2019 11 20; 11(519).
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Ji W, Smith PN, Koepsel RR, Andersen JD, Baker SL, Zhang L, Carmali S, Myerson JW, Muzykantov V, Russell AJ. Erythrocytes as carriers of immunoglobulin-based therapeutics. Acta Biomater. 2020 01 01; 101:422-435.
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Vu VP, Gifford GB, Chen F, Benasutti H, Wang G, Groman EV, Scheinman R, Saba L, Moghimi SM, Simberg D. Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles. Nat Nanotechnol. 2019 03; 14(3):260-268.
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