 Myofibroblasts
"Myofibroblasts" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Spindle-shaped cells with characteristic CONTRACTILE PROTEINS and structures that contribute to the WOUND HEALING process. They occur in GRANULATION TISSUE and also in pathological processes such as FIBROSIS.
| Descriptor ID |
D058628
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| MeSH Number(s) |
A11.329.228.975 A11.620.520.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Myofibroblasts".
Below are MeSH descriptors whose meaning is more specific than "Myofibroblasts".
This graph shows the total number of publications written about "Myofibroblasts" by people in this website by year, and whether "Myofibroblasts" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 1 | 2 | | 2011 | 3 | 1 | 4 | | 2012 | 3 | 1 | 4 | | 2013 | 1 | 0 | 1 | | 2014 | 2 | 3 | 5 | | 2015 | 4 | 0 | 4 | | 2016 | 2 | 1 | 3 | | 2017 | 7 | 3 | 10 | | 2018 | 2 | 5 | 7 | | 2019 | 4 | 3 | 7 | | 2020 | 4 | 2 | 6 | | 2021 | 2 | 4 | 6 | | 2022 | 5 | 4 | 9 | | 2023 | 3 | 2 | 5 | | 2024 | 1 | 1 | 2 | | 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "Myofibroblasts" by people in Profiles.
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Khang A, Barmore A, Tseropoulos G, Bera K, Batan D, Anseth KS. Automated prediction of fibroblast phenotypes using mathematical descriptors of cellular features. Nat Commun. 2025 Mar 22; 16(1):2841.
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Gorashi RM, Baddour T, Chittle SJ, F?lix V?lez NE, Wenning MA, Anseth KS, Mestroni L, Pe?a B, Guo P, Aguado BA. Y chromosome-linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues. Sci Adv. 2025 Mar 14; 11(11):eads5717.
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Johansen AKZ, Kasam RK, Vagnozzi RJ, Lin SJ, Gomez-Arroyo J, Shittu A, Bowers SLK, Kuwabara Y, Grimes KM, Warrick K, Sargent MA, Baldwin TA, Quaggin SE, Barski A, Molkentin JD. Transcription Factor 21 Regulates Cardiac Myofibroblast Formation and Fibrosis. Circ Res. 2025 Jan 03; 136(1):44-58.
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Amrute JM, Luo X, Penna V, Yang S, Yamawaki T, Hayat S, Bredemeyer A, Jung IH, Kadyrov FF, Heo GS, Venkatesan R, Shi SY, Parvathaneni A, Koenig AL, Kuppe C, Baker C, Luehmann H, Jones C, Kopecky B, Zeng X, Bleckwehl T, Ma P, Lee P, Terada Y, Fu A, Furtado M, Kreisel D, Kovacs A, Stitziel NO, Jackson S, Li CM, Liu Y, Rosenthal NA, Kramann R, Ason B, Lavine KJ. Targeting immune-fibroblast cell communication in heart failure. Nature. 2024 Nov; 635(8038):423-433.
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Felisbino MB, Rubino M, Travers JG, Schuetze KB, Lemieux ME, Anseth KS, Aguado BA, McKinsey TA. Substrate stiffness modulates cardiac fibroblast activation, senescence, and proinflammatory secretory phenotype. Am J Physiol Heart Circ Physiol. 2024 01 01; 326(1):H61-H73.
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Jolly AJ, Lu S, Dubner AM, Strand KA, Mutryn MF, Pilotti-Riley A, Danis EP, Nemenoff RA, Moulton KS, Majesky MW, Weiser-Evans MC. Redistribution of the chromatin remodeler Brg1 directs smooth muscle-derived adventitial progenitor-to-myofibroblast differentiation and vascular fibrosis. JCI Insight. 2023 05 08; 8(9).
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Wang S, Rao W, Hoffman A, Lin J, Li J, Lin T, Liew AA, Vincent M, Mertens TCJ, Karmouty-Quintana H, Crum CP, Metersky ML, Schwartz DA, Davies PJA, Stephan C, Jyothula SSK, Sheshadri A, Suarez EE, Huang HJ, Engelhardt JF, Dickey BF, Parekh KR, McKeon FD, Xian W. Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis. Sci Transl Med. 2023 04 26; 15(693):eabp9528.
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Geiger F, Zeitlmayr S, Staab-Weijnitz CA, Rajan S, Breit A, Gudermann T, Dietrich A. An Inhibitory Function of TRPA1 Channels in TGF-?1-driven Fibroblast-to-Myofibroblast Differentiation. Am J Respir Cell Mol Biol. 2023 03; 68(3):314-325.
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Huang Y, Guzy R, Ma SF, Bonham CA, Jou J, Schulte JJ, Kim JS, Barros AJ, Espindola MS, Husain AN, Hogaboam CM, Sperling AI, Noth I. Central lung gene expression associates with myofibroblast features in idiopathic pulmonary fibrosis. BMJ Open Respir Res. 2023 02; 10(1).
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Vogt BJ, Peters DK, Anseth KS, Aguado BA. Inflammatory serum factors from aortic valve stenosis patients modulate sex differences in valvular myofibroblast activation and osteoblast-like differentiation. Biomater Sci. 2022 Nov 08; 10(22):6341-6353.
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