 Src Homology 2 Domain-Containing, Transforming Protein 1
"Src Homology 2 Domain-Containing, Transforming Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.
| Descriptor ID |
D000071425
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| MeSH Number(s) |
D12.644.360.024.330.500 D12.776.157.057.162.500 D12.776.476.024.424.500
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| Concept/Terms |
Src Homology 2 Domain-Containing, Transforming Protein 1- Src Homology 2 Domain-Containing, Transforming Protein 1
- Src Homology 2 Domain Containing, Transforming Protein 1
- ShcA Protein
- SHC1 (Src Homology 2 Domain-Containing) Protein
- Src Homology 2 Domain-Containing-Transforming Protein C1
- Src Homology 2 Domain Containing Transforming Protein C1
- SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
- SHC1 Protein
- SHC-Transforming Protein 1
- SHC Transforming Protein 1
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Below are MeSH descriptors whose meaning is more general than "Src Homology 2 Domain-Containing, Transforming Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Src Homology 2 Domain-Containing, Transforming Protein 1".
This graph shows the total number of publications written about "Src Homology 2 Domain-Containing, Transforming Protein 1" by people in this website by year, and whether "Src Homology 2 Domain-Containing, Transforming Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1996 | 0 | 2 | 2 | | 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Src Homology 2 Domain-Containing, Transforming Protein 1" by people in Profiles.
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Miller DR, Ingersoll MA, Chatterjee A, Baker B, Shrishrimal S, Kosmacek EA, Zhu Y, Cheng PW, Oberley-Deegan RE, Lin MF. p66Shc protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance. Free Radic Biol Med. 2019 08 01; 139:24-34.
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Ingersoll MA, Chou YW, Lin JS, Yuan TC, Miller DR, Xie Y, Tu Y, Oberley-Deegan RE, Batra SK, Lin MF. p66Shc regulates migration of castration-resistant prostate cancer cells. Cell Signal. 2018 06; 46:1-14.
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LaRocca TJ, Hearon CM, Henson GD, Seals DR. Mitochondrial quality control and age-associated arterial stiffening. Exp Gerontol. 2014 Oct; 58:78-82.
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Almeida M, Martin-Millan M, Ambrogini E, Bradsher R, Han L, Chen XD, Roberson PK, Weinstein RS, O'Brien CA, Jilka RL, Manolagas SC. Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha. J Bone Miner Res. 2010 Apr; 25(4):769-81.
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Li W, Li F, Huang Q, Frederick B, Bao S, Li CY. Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo. Cancer Res. 2008 Jul 01; 68(13):4990-7.
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Tyagi A, Agarwal R, Agarwal C. Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. Oncogene. 2003 Mar 06; 22(9):1302-16.
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Goalstone ML, Leitner JW, Berhanu P, Sharma PM, Olefsky JM, Draznin B. Insulin signals to prenyltransferases via the Shc branch of intracellular signaling. J Biol Chem. 2001 Apr 20; 276(16):12805-12.
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Mainiero F, Gismondi A, Soriani A, Cippitelli M, Palmieri G, Jacobelli J, Piccoli M, Frati L, Santoni A. Integrin-mediated ras-extracellular regulated kinase (ERK) signaling regulates interferon gamma production in human natural killer cells. J Exp Med. 1998 Oct 05; 188(7):1267-75.
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Piccoletti R, Bendinelli P, Maroni P. Signal transduction pathway of prolactin in rat liver. Mol Cell Endocrinol. 1997 Dec 12; 135(2):169-77.
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Pao LI, Bedzyk WD, Persin C, Cambier JC. Molecular targets of CD45 in B cell antigen receptor signal transduction. J Immunol. 1997 Feb 01; 158(3):1116-24.
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