 Src Homology 2 Domain-Containing, Transforming Protein 1
"Src Homology 2 Domain-Containing, Transforming Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.
| Descriptor ID |
D000071425
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| MeSH Number(s) |
D12.644.360.024.330.500 D12.776.157.057.162.500 D12.776.476.024.424.500
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| Concept/Terms |
Src Homology 2 Domain-Containing, Transforming Protein 1- Src Homology 2 Domain-Containing, Transforming Protein 1
- Src Homology 2 Domain Containing, Transforming Protein 1
- ShcA Protein
- SHC1 (Src Homology 2 Domain-Containing) Protein
- Src Homology 2 Domain-Containing-Transforming Protein C1
- Src Homology 2 Domain Containing Transforming Protein C1
- SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
- SHC1 Protein
- SHC-Transforming Protein 1
- SHC Transforming Protein 1
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Below are MeSH descriptors whose meaning is more general than "Src Homology 2 Domain-Containing, Transforming Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Src Homology 2 Domain-Containing, Transforming Protein 1".
This graph shows the total number of publications written about "Src Homology 2 Domain-Containing, Transforming Protein 1" by people in this website by year, and whether "Src Homology 2 Domain-Containing, Transforming Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 1996 | 0 | 2 | 2 | | 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Src Homology 2 Domain-Containing, Transforming Protein 1" by people in Profiles.
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Miller DR, Ingersoll MA, Chatterjee A, Baker B, Shrishrimal S, Kosmacek EA, Zhu Y, Cheng PW, Oberley-Deegan RE, Lin MF. p66Shc protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance. Free Radic Biol Med. 2019 08 01; 139:24-34.
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Ingersoll MA, Chou YW, Lin JS, Yuan TC, Miller DR, Xie Y, Tu Y, Oberley-Deegan RE, Batra SK, Lin MF. p66Shc regulates migration of castration-resistant prostate cancer cells. Cell Signal. 2018 06; 46:1-14.
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LaRocca TJ, Hearon CM, Henson GD, Seals DR. Mitochondrial quality control and age-associated arterial stiffening. Exp Gerontol. 2014 Oct; 58:78-82.
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Li W, Li F, Huang Q, Frederick B, Bao S, Li CY. Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo. Cancer Res. 2008 Jul 01; 68(13):4990-7.
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Tyagi A, Agarwal R, Agarwal C. Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. Oncogene. 2003 Mar 06; 22(9):1302-16.
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Ott VL, Tamir I, Niki M, Pandolfi PP, Cambier JC. Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling. J Immunol. 2002 May 01; 168(9):4430-9.
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Goalstone ML, Leitner JW, Berhanu P, Sharma PM, Olefsky JM, Draznin B. Insulin signals to prenyltransferases via the Shc branch of intracellular signaling. J Biol Chem. 2001 Apr 20; 276(16):12805-12.
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Mainiero F, Gismondi A, Soriani A, Cippitelli M, Palmieri G, Jacobelli J, Piccoli M, Frati L, Santoni A. Integrin-mediated ras-extracellular regulated kinase (ERK) signaling regulates interferon gamma production in human natural killer cells. J Exp Med. 1998 Oct 05; 188(7):1267-75.
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Piccoletti R, Bendinelli P, Maroni P. Signal transduction pathway of prolactin in rat liver. Mol Cell Endocrinol. 1997 Dec 12; 135(2):169-77.
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Pao LI, Bedzyk WD, Persin C, Cambier JC. Molecular targets of CD45 in B cell antigen receptor signal transduction. J Immunol. 1997 Feb 01; 158(3):1116-24.
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