Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Marc Lee Goalstone

TitleAffiliate - VA
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/399-8020

    Collapse Research 
    Collapse research activities and funding
    IS1BX003574     (GOALSTONE, MARC LEE)May 1, 2016 - Sep 30, 2016
    NIH
    ShEEP Request for Flow Cytometer Special Order Laser Upgrade
    Role: Principal Investigator
    I01BX002019     (GOALSTONE, MARC LEE)Apr 1, 2014 - Mar 31, 2018
    NIH
    Diabetes: ERK5 and Vascular Inflammation
    Role: Principal Investigator
    R01DK068236     (GOALSTONE, MARC LEE)Mar 1, 2005 - Feb 28, 2009
    NIH
    Macrovascular Dysfunction of Diabetes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Veluthakal R, Arora DK, Goalstone ML, Kowluru RA, Kowluru A. Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic ?-Cells. Cell Physiol Biochem. 2016; 39(6):2110-2120. PMID: 27802439.
      View in: PubMed
    2. Goalstone ML, Pugazhenthi S. Editorial: Molecular Mechanism of Neuronal Dysfunction in the Diabetic Brain. Front Endocrinol (Lausanne). 2016; 7:45. PMID: 27242668.
      View in: PubMed
    3. Pott GB, Tsurudome M, Bamfo N, Goalstone ML. ERK2 and Akt are negative regulators of insulin and Tumor Necrosis Factor-a stimulated VCAM-1 expression in rat aorta endothelial cells. J Inflamm (Lond). 2016; 13:6. PMID: 26917991.
      View in: PubMed
    4. Mackesy DZ, Goalstone ML. Extracellular signal-regulated kinase-5: Novel mediator of insulin and tumor necrosis factor a-stimulated vascular cell adhesion molecule-1 expression in vascular cells. J Diabetes. 2014 Nov; 6(6):595-602. PMID: 24460840.
      View in: PubMed
    5. Mackesy DZ, Goalstone ML. Insulin augments tumor necrosis factor-alpha stimulated expression of vascular cell adhesion molecule-1 in vascular endothelial cells. J Inflamm (Lond). 2011 Nov 17; 8:34. PMID: 22093181.
      View in: PubMed
    6. Goalstone ML. ERK5: a novel IKKa-kinase in rat hippocampal neurons. Can J Neurol Sci. 2011 Jul; 38(4):639-48. PMID: 21672705.
      View in: PubMed
    7. Goalstone M, Kamath V, Kowluru A. Glucose activates prenyltransferases in pancreatic islet beta-cells. Biochem Biophys Res Commun. 2010 Jan 01; 391(1):895-8. PMID: 19951701.
      View in: PubMed
    8. Sharma G, Goalstone ML. Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells. Biochem Biophys Res Commun. 2007 Mar 23; 354(4):1078-83. PMID: 17275785.
      View in: PubMed
    9. Veluthakal R, Kaur H, Goalstone M, Kowluru A. Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells. Diabetes. 2007 Jan; 56(1):204-10. PMID: 17192483.
      View in: PubMed
    10. Sharma G, Goalstone ML. Dominant negative FTase (DNFTalpha) inhibits ERK5, MEF2C and CREB activation in adipogenesis. Mol Cell Endocrinol. 2005 Dec 21; 245(1-2):93-104. PMID: 16356629.
      View in: PubMed
    11. Cornier MA, Donahoo WT, Pereira R, Gurevich I, Westergren R, Enerback S, Eckel PJ, Goalstone ML, Hill JO, Eckel RH, Draznin B. Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women. Obes Res. 2005 Apr; 13(4):703-9. PMID: 15897479.
      View in: PubMed
    12. Wang CC, Goalstone ML, Draznin B. Molecular mechanisms of insulin resistance that impact cardiovascular biology. Diabetes. 2004 Nov; 53(11):2735-40. PMID: 15504952.
      View in: PubMed
    13. Finlayson CA, Chappell J, Leitner JW, Goalstone ML, Garrity M, Nawaz S, Ciaraldi TP, Draznin B. Enhanced insulin signaling via Shc in human breast cancer. Metabolism. 2003 Dec; 52(12):1606-11. PMID: 14669164.
      View in: PubMed
    14. Golovchenko I, Yang CH, Goalstone ML, Draznin B. Garlic extract methylallyl thiosulfinate blocks insulin potentiation of platelet-derived growth factor-stimulated migration of vascular smooth muscle cells. Metabolism. 2003 Feb; 52(2):254-9. PMID: 12601642.
      View in: PubMed
    15. Solomon CS, Leitner JW, Goalstone ML. Dominant negative alpha-subunit of farnesyl- and geranylgeranyl-transferase I inhibits insulin-induced differentiation of 3T3-L1 pre-adipocytes. Int J Obes Relat Metab Disord. 2003 Jan; 27(1):40-7. PMID: 12532152.
      View in: PubMed
    16. Solomon CS, Goalstone ML. Dominant negative alpha-subunit of FTase inhibits effects of insulin and IGF-I in MCF-7 cells. Biochem Biophys Res Commun. 2002 Mar 01; 291(3):458-65. PMID: 11855811.
      View in: PubMed
    17. Montagnani M, Golovchenko I, Kim I, Koh GY, Goalstone ML, Mundhekar AN, Johansen M, Kucik DF, Quon MJ, Draznin B. Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells. J Biol Chem. 2002 Jan 18; 277(3):1794-9. PMID: 11707433.
      View in: PubMed
    18. Chappell J, Leitner JW, Solomon S, Golovchenko I, Goalstone ML, Draznin B. Effect of insulin on cell cycle progression in MCF-7 breast cancer cells. Direct and potentiating influence. J Biol Chem. 2001 Oct 12; 276(41):38023-8. PMID: 11500498.
      View in: PubMed
    19. Stephens E, Thureen PJ, Goalstone ML, Anderson MS, Leitner JW, Hay WW, Draznin B. Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues. Am J Physiol Endocrinol Metab. 2001 Aug; 281(2):E217-23. PMID: 11440896.
      View in: PubMed
    20. Solomon CS, Goalstone ML. Dominant negative farnesyltransferase alpha-subunit inhibits insulin mitogenic effects. Biochem Biophys Res Commun. 2001 Jul 13; 285(2):161-6. PMID: 11444820.
      View in: PubMed
    21. Klemm DJ, Leitner JW, Watson P, Nesterova A, Reusch JE, Goalstone ML, Draznin B. Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation. J Biol Chem. 2001 Jul 27; 276(30):28430-5. PMID: 11375992.
      View in: PubMed
    22. Goalstone ML, Leitner JW, Berhanu P, Sharma PM, Olefsky JM, Draznin B. Insulin signals to prenyltransferases via the Shc branch of intracellular signaling. J Biol Chem. 2001 Apr 20; 276(16):12805-12. PMID: 11278505.
      View in: PubMed
    23. Golovchenko I, Goalstone ML, Watson P, Brownlee M, Draznin B. Hyperinsulinemia enhances transcriptional activity of nuclear factor-kappaB induced by angiotensin II, hyperglycemia, and advanced glycosylation end products in vascular smooth muscle cells. Circ Res. 2000 Oct 27; 87(9):746-52. PMID: 11055977.
      View in: PubMed
    24. Chappell J, Golovchenko I, Wall K, Stjernholm R, Leitner JW, Goalstone M, Draznin B. Potentiation of Rho-A-mediated lysophosphatidic acid activity by hyperinsulinemia. J Biol Chem. 2000 Oct 13; 275(41):31792-7. PMID: 10930411.
      View in: PubMed
    25. Draznin B, Miles P, Kruszynska Y, Olefsky J, Friedman J, Golovchenko I, Stjernholm R, Wall K, Reitman M, Accili D, Cooksey R, McClain D, Goalstone M. Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia. Endocrinology. 2000 Apr; 141(4):1310-6. PMID: 10746633.
      View in: PubMed
    26. Goalstone ML, Sadler SE. Analysis of farnesyl transferase activity during hormone-induced maturation of Xenopus laevis oocytes. J Exp Zool. 2000 Feb 01; 286(2):193-203. PMID: 10617861.
      View in: PubMed
    27. Goalstone ML, Wall K, Leitner JW, Kurowski T, Ruderman N, Pan SJ, Ivy JL, Moller DE, Draznin B. Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals. Diabetologia. 1999 Mar; 42(3):310-6. PMID: 10096783.
      View in: PubMed
    28. Goalstone ML, Leitner JW, Golovchenko I, Stjernholm MR, Cormont M, Le Marchand-Brustel Y, Draznin B. Insulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4. J Biol Chem. 1999 Jan 29; 274(5):2880-4. PMID: 9915824.
      View in: PubMed
    29. Goalstone ML, Draznin B. Effect of insulin on farnesyltransferase gene transcription and mRNA stability. Biochem Biophys Res Commun. 1999 Jan 08; 254(1):243-7. PMID: 9920764.
      View in: PubMed
    30. Goalstone ML, Natarajan R, Standley PR, Walsh MF, Leitner JW, Carel K, Scott S, Nadler J, Sowers JR, Draznin B. Insulin potentiates platelet-derived growth factor action in vascular smooth muscle cells. Endocrinology. 1998 Oct; 139(10):4067-72. PMID: 9751484.
      View in: PubMed
    31. Goalstone ML, Leitner JW, Wall K, Dolgonos L, Rother KI, Accili D, Draznin B. Effect of insulin on farnesyltransferase. Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor. J Biol Chem. 1998 Sep 11; 273(37):23892-6. PMID: 9727002.
      View in: PubMed
    32. Goalstone ML, Draznin B. What does insulin do to Ras? Cell Signal. 1998 May; 10(5):297-301. PMID: 9692672.
      View in: PubMed
    33. Goalstone M, Carel K, Leitner JW, Draznin B. Insulin stimulates the phosphorylation and activity of farnesyltransferase via the Ras-mitogen-activated protein kinase pathway. Endocrinology. 1997 Dec; 138(12):5119-24. PMID: 9389491.
      View in: PubMed
    34. Goalstone M, Leitner JW, Draznin B. GTP loading of farnesylated p21Ras by insulin at the plasma membrane. Biochem Biophys Res Commun. 1997 Oct 09; 239(1):42-5. PMID: 9345266.
      View in: PubMed
    35. Goalstone ML, Draznin B. Insulin signaling. West J Med. 1997 Sep; 167(3):166-73. PMID: 9308409.
      View in: PubMed
    36. Leitner JW, Kline T, Carel K, Goalstone M, Draznin B. Hyperinsulinemia potentiates activation of p21Ras by growth factors. Endocrinology. 1997 May; 138(5):2211-4. PMID: 9112423.
      View in: PubMed
    37. Goalstone ML, Draznin B. Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes. J Biol Chem. 1996 Nov 01; 271(44):27585-9. PMID: 8910345.
      View in: PubMed
    38. Stith BJ, Goalstone ML, Espinoza R, Mossel C, Roberts D, Wiernsperger N. The antidiabetic drug metformin elevates receptor tyrosine kinase activity and inositol 1,4,5-trisphosphate mass in Xenopus oocytes. Endocrinology. 1996 Jul; 137(7):2990-9. PMID: 8770923.
      View in: PubMed
    39. Goalstone ML, Diamond CL, Sadler SE. Characterization of Xenopus laevis oocyte farnesyl transferase. Biol Reprod. 1996 Mar; 54(3):675-81. PMID: 8835391.
      View in: PubMed
    Goalstone's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (243) concept(s)
    _
    Co-Authors Expand Description
    See all (7) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2025 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)