 Trans-Splicing
"Trans-Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
| Descriptor ID |
D020040
|
| MeSH Number(s) |
G02.111.760.700.750 G03.839.700.750 G05.308.700.700.750
|
| Concept/Terms |
Trans-Splicing- Trans-Splicing
- Trans Splicing
- Splicing, Trans
- RNA Trans-Splicing
- RNA Trans Splicing
- Trans-Splicings, RNA
- Trans RNA Splicing
- RNA Splicing, Trans
|
Below are MeSH descriptors whose meaning is more general than "Trans-Splicing".
Below are MeSH descriptors whose meaning is more specific than "Trans-Splicing".
This graph shows the total number of publications written about "Trans-Splicing" by people in this website by year, and whether "Trans-Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2010 | 4 | 0 | 4 | | 2011 | 2 | 0 | 2 | | 2013 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Trans-Splicing" by people in Profiles.
-
Iyer V, Chettiar ST, Grover M, Rajyaguru P, Nageshan RK, Tatu U. Giardia lamblia Hsp90 pre-mRNAs undergo self-splicing to generate mature RNA in an in vitro trans-splicing reaction. FEBS Lett. 2019 02; 593(4):433-442.
-
Saito TL, Hashimoto S, Gu SG, Morton JJ, Stadler M, Blumenthal T, Fire A, Morishita S. The transcription start site landscape of C. elegans. Genome Res. 2013 Aug; 23(8):1348-61.
-
Lasda EL, Kuersten S, Blumenthal T. SL trans-splicing in a Caenorhabditis elegans in vitro extract. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5574.
-
Lasda EL, Blumenthal T. Trans-splicing. Wiley Interdiscip Rev RNA. 2011 May-Jun; 2(3):417-34.
-
Allen MA, Hillier LW, Waterston RH, Blumenthal T. A global analysis of C. elegans trans-splicing. Genome Res. 2011 Feb; 21(2):255-64.
-
Morton JJ, Blumenthal T. Identification of transcription start sites of trans-spliced genes: uncovering unusual operon arrangements. RNA. 2011 Feb; 17(2):327-37.
-
Lasda EL, Allen MA, Blumenthal T. Polycistronic pre-mRNA processing in vitro: snRNP and pre-mRNA role reversal in trans-splicing. Genes Dev. 2010 Aug 01; 24(15):1645-58.
-
Garrido-Lecca A, Blumenthal T. RNA polymerase II C-terminal domain phosphorylation patterns in Caenorhabditis elegans operons, polycistronic gene clusters with only one promoter. Mol Cell Biol. 2010 Aug; 30(15):3887-93.
-
Wallace A, Filbin ME, Veo B, McFarland C, Stepinski J, Jankowska-Anyszka M, Darzynkiewicz E, Davis RE. The nematode eukaryotic translation initiation factor 4E/G complex works with a trans-spliced leader stem-loop to enable efficient translation of trimethylguanosine-capped RNAs. Mol Cell Biol. 2010 Apr; 30(8):1958-70.
-
Cheng G, Cohen L, Mikhli C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE. In vivo translation and stability of trans-spliced mRNAs in nematode embryos. Mol Biochem Parasitol. 2007 Jun; 153(2):95-106.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|