 Glycochenodeoxycholic Acid
"Glycochenodeoxycholic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.
| Descriptor ID |
D005999
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| MeSH Number(s) |
D04.210.500.105.225.272.150.350 D04.210.500.105.225.272.411.360 D04.210.500.105.225.400.380.360 D04.210.500.221.430.342.300.400 D04.210.500.221.430.342.400.450 D04.210.500.221.430.484.430.420 D12.125.481.700.249.420.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Glycochenodeoxycholic Acid".
Below are MeSH descriptors whose meaning is more specific than "Glycochenodeoxycholic Acid".
This graph shows the total number of publications written about "Glycochenodeoxycholic Acid" by people in this website by year, and whether "Glycochenodeoxycholic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Glycochenodeoxycholic Acid" by people in Profiles.
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Gumpricht E, Devereaux MW, Dahl R, Soden JS, Sparagna GC, Leonard SW, Traber MG, Sokol RJ. Resistance of young rat hepatic mitochondria to bile acid-induced permeability transition: potential role of alpha-tocopherol. Pediatr Res. 2008 Nov; 64(5):498-504.
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Soden JS, Devereaux MW, Haas JE, Gumpricht E, Dahl R, Gralla J, Traber MG, Sokol RJ. Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis. Hepatology. 2007 Aug; 46(2):485-95.
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Sokol RJ, Dahl R, Devereaux MW, Yerushalmi B, Kobak GE, Gumpricht E. Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids. J Pediatr Gastroenterol Nutr. 2005 Aug; 41(2):235-43.
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Kobak GE, Dahl R, Devereaux MW, Gumpricht E, Traber M, Doctor RB, Sokol RJ. Increased susceptibility of fat-laden Zucker-rat hepatocytes to bile acid-induced oncotic necrosis: an in vitro model of steatocholestasis. J Lab Clin Med. 2005 May; 145(5):247-62.
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Jaiswal K, Tello V, Lopez-Guzman C, Nwariaku F, Anthony T, Sarosi GA. Bile salt exposure causes phosphatidyl-inositol-3-kinase-mediated proliferation in a Barrett's adenocarcinoma cell line. Surgery. 2004 Aug; 136(2):160-8.
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Gumpricht E, Dahl R, Devereaux MW, Sokol RJ. Beta-carotene prevents bile acid-induced cytotoxicity in the rat hepatocyte: Evidence for an antioxidant and anti-apoptotic role of beta-carotene in vitro. Pediatr Res. 2004 May; 55(5):814-21.
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Gumpricht E, Dahl R, Yerushalmi B, Devereaux MW, Sokol RJ. Nitric oxide ameliorates hydrophobic bile acid-induced apoptosis in isolated rat hepatocytes by non-mitochondrial pathways. J Biol Chem. 2002 Jul 12; 277(28):25823-30.
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Yerushalmi B, Dahl R, Devereaux MW, Gumpricht E, Sokol RJ. Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition. Hepatology. 2001 Mar; 33(3):616-26.
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Gumpricht E, Devereaux MW, Dahl RH, Sokol RJ. Glutathione status of isolated rat hepatocytes affects bile acid-induced cellular necrosis but not apoptosis. Toxicol Appl Pharmacol. 2000 Apr 01; 164(1):102-11.
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Shivaram KN, Winklhofer-Roob BM, Straka MS, Devereaux MW, Everson G, Mierau GW, Sokol RJ. The effect of idebenone, a coenzyme Q analogue, on hydrophobic bile acid toxicity to isolated rat hepatocytes and hepatic mitochondria. Free Radic Biol Med. 1998 Sep; 25(4-5):480-92.
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